References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 1401 to 1500 of 56370     10 11 12 13 14 15 16 17 18 19 20     Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopeniaReginster, Jean-Yves ; Cooper, Cyrus; Rizzoli, René et alin Aging Clinical and Experimental Research (2016), 28(1), 47-58Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a ... [more ▼]Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities. Methods: A multidisciplinary expert working group was hosted by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, which reviewed and discussed the recent literature from a perspective of clinical experience and guideline development. Relevant parallels were drawn from the development of definition of osteoporosis as a disease and clinical assessment of pharmaceutical treatments for that indication. Results A case-finding decision tree is briefly reviewed with a discussion of recent prevalence estimations of different relevant threshold values. The selection criteria for patients in regulatory studies are discussed according to the aims of the investigation (sarcopenia prevention or treatment) and the stage of project development. The possible endpoints of such studies are reviewed and a pleais made for the establishment of a core outcome set to be used in all clinical trials of sarcopenia. Conclusions : The current lack of guidelines for the assessment of new therapeutic treatments for sarcopenia could potentially hinder the delivery of effective medicines to patients at risk. [less ▲]Detailed reference viewed: 32 (12 ULg) Le tarif des corps accidentés: genèse, mobilisations et pratiques judiciaires. France-Belgique (premier XXe siècle)Bruno, Anne-Sophie; Geerkens, Eric in Revue du Nord (2016), n° 35 HS coll. HistoireDetailed reference viewed: 5 (0 ULg) A review of the characteristics of Small-Leaved Lime (Tilia cordata Mill.) and their implications for silviculture in a changing climateDe Jaegere, Tanguy; Hein, Sébastien; Claessens, Hugues in Forests (2016), 7(3), 56Tilia cordata Mill. is a minor European broadleaved species with a wide but scattered distribution. Given its scarcity and low value in the wood market, it has received little attention from researchers ... [more ▼]Tilia cordata Mill. is a minor European broadleaved species with a wide but scattered distribution. Given its scarcity and low value in the wood market, it has received little attention from researchers and forest managers. This review summarizes the main aspects of T. cordata ecology and growth. Its main limiting factor is its need for warm summer temperatures to ensure successful seed production. It has a height growth pattern relatively similar to that of Acer pseudoplatanus L., with a slight delay in the early stages. Yield tables report great productivity, especially in eastern Europe. T. cordata used to be a major species in Europe, in contrast to its present distribution, but it is very likely to receive renewed interest in the future. Indeed, with the potential change of competition between species in some regions and the need for important diversification in others, T. cordata may play an important role in forest adaptation to climate change, especially owing to its wide ecological tolerance and its numerous ecosystem services. It is necessary to increase our knowledge about its regeneration and its responses to environmental and silvicultural factors, to establish clear management recommendations. [less ▲]Detailed reference viewed: 9 (2 ULg) . Mass sensor utilising the mode-localisation effect in an electrostatically-coupled MEMS resonator pair fabricated using an SOI processWood, Graham; Chun, Zhao; Pu, Suan et alin Microelectronic Engineering (2016), 159The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode ... [more ▼]The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode-localisation effect. It has been demonstrated that the shift in the amplitude ratio of the coupled-resonators at the in-phase mode frequency, in response to a mass change, is ﬁve orders of magnitude greater than the equivalent resonant frequency shift of a single resonator device. The device has been fabricated using a silicon-on-insulator (SOI) based process, which allows for high-yield and stiction-free fabrication. In addition, the design of the resonators has been created to have a larger surface area than previously reported designs, in order to facilitate future biological functionalisation. The mass sensitivity has been compared to current state-of-the-art mode-localised mass sensors and a 5.4 times increase in the amplitude ratio response to a given mass change has been demonstrated for the device in this work. [less ▲]Detailed reference viewed: 11 (2 ULg) De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.Haas, Matilda A.; Ngo, Linh; Li, Shan Shan et alin Cell Reports (2016)Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation ... [more ▼]Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1, whereas perturbations to Denr impair the long-term positioning, dendritic arborization, and dendritic spine characteristics of postnatal projection neurons. We characterized de novo missense mutations in DENR (p.C37Y and p.P121L) detected in two unrelated human subjects diagnosed with brain developmental disorder to find that each variant impairs the function of DENR in mRNA translation re-initiation and disrupts the migration and terminal branching of cortical neurons in different ways. Thus, our findings link human brain disorders to impaired mRNA translation re-initiation through perturbations in DENR (OMIM: 604550) function in neurons. [less ▲]Detailed reference viewed: 30 (1 ULg) Vitellogenin and vitellogenin receptor gene expression and 20-hydroxyecdysone concentration in Macrobrachium rosenbergii exposed to chlordeconeLafontaine, Anne ; Hanikenne, Marc ; Boulangé-Lecomte, Céline et alin Environmental Science and Pollution Research (2016)Detailed reference viewed: 20 (5 ULg) New data about anatomy, branching, and inferred growth patterns in the Early Devonian plant Armoricaphyton chateaupannense, Montjean-sur-Loire, FranceGerrienne, Philippe ; Gensel, PGin Review of Palaeobotany and Palynology (2016), 224(Part 1), 38-53This study provides detailed information, based on serial peels, on the anatomy of the primary and secondary xylem, lateral branch formation, and proposed growth pattern of Armoricaphyton Strullu-Derrien ... [more ▼]This study provides detailed information, based on serial peels, on the anatomy of the primary and secondary xylem, lateral branch formation, and proposed growth pattern of Armoricaphyton Strullu-Derrien et al., an Early Devonian (Pragian) basal euphyllophyte. The centrarch primary xylem strand is circular to oval in cross section and includes P-type tracheids. The pattern of lateral branch departure is described in detail based on serial peels. The secondary xylem, illustrated in transverse, radial and tangential longitudinal sections, includes P-type tracheids with similar pitting in radial and tangential walls. The presence of one-walled spaces interpreted as rays is confirmed. This study also documents the earliest occurrence of secondary xylem at bases of next higher order of branches. A model of growth for this unusual Early Devonian plant is presented, with documented epidogenetic, menetogenetic and possible apoxogenetic phases. The difference in proportion of primary tosecondary xylem is postulated to be a result of this mode of growth. The possible implications of xylem size and organization in the lateral organ in Armoricaphyton relative to the early evolution of the megaphyllous leaf are briefly discussed. [less ▲]Detailed reference viewed: 16 (4 ULg) Fossil Biogeography: A new model to infer dispersal, extinction and sampling from paleontological dataSilvestro, Daniele; Zizka, Alexander; Bacon, Christine D. et alin Philosophical Transactions : Biological Sciences (2016)Detailed reference viewed: 79 (3 ULg) Pratique de l'ostéosynthèse des fractures de jambe en République démocratique du CongoAmisi Kitoko, R.; Asolanyongo, M.K.; Losimba, J.L. et alin Revue de Chirurgie Orthopédique et traumatologique (2016), 102(3), 306-9La prise en charge chirurgicale de la traumatologie à Kisangani (République démocratique du Congo) se heurte à des contraintes médico-économiques et culturelles qui aboutissent souvent à des prises en ... [more ▼]La prise en charge chirurgicale de la traumatologie à Kisangani (République démocratique du Congo) se heurte à des contraintes médico-économiques et culturelles qui aboutissent souvent à des prises en charge retardées. Le but de cette étude était de déterminer les délais de prise en charge, les délais opératoires et de les corréler aux complications postopératoires. Les résultats radiologiques et fonctionnels des fractures de jambe ont été également évalués. Notre hypothèse était que le taux de complications est significativement plus élevé en cas de prise en charge retardée. Cette étude rétrospective a été réalisée aux cliniques universitaires de Kisangani de 1996 à 2009. Soixante-seize fractures de jambe ou du pilon tibial traitées par ostéosynthèse interne ou externe à foyer fermé ou ouvert ont été analysées. Les résultats radiologiques et fonctionnels ont été évalués à 12 mois minimum. La prise en charge des patients était tardive. Le délai moyen d’admission à l’hôpital était de 19 ± 18,28 jours (extrêmes de 1 à 90 jours) avec une différence significative des complications selon le délai d’admission (p < 0,05) aux dépens des patients admis tardivement. Le délai opératoire moyen après l’admission était de 9,5 ± 8,51 jours (extrêmes de 1 à 30 jours) avec une différence significative des complications selon le délai opératoire (p < 0,05) aux dépens des patients opérés tardivement (infections, pseudarthrose). Le délai d’admission ou opératoire n’influençait pas les résultats fonctionnels (p > 0,05). Ces résultats sont cohérents avec ceux rapportés dans la littérature. Le retard de la chirurgie est associé à l’augmentation de complications postopératoires (infection, pseudarthrose) et de la durée d’hospitalisation. Un retard opératoire de plus de 48 heures doit être évité, sauf pour les patients médicalement instables qui nécessitent une période de stabilisation médicale. Niveau de preuve. – Niveau IV : rétrospectif – série historique. [less ▲]Detailed reference viewed: 19 (3 ULg) Bacterial community composition in relation to bedrock type and macrobiota in soils 1 from the Sør Rondane Mountains, East AntarcticaTytgat, Bjorn; Verleyen, Elie; Sweetlove, Maxime et alin FEMS Microbiology Ecology (2016), 92Antarctic soils are known to be oligotrophic and of having low buffering capacities. It is expected that this is particularly the case for inland high altitude regions. We hypothesized that the bedrock ... [more ▼]Antarctic soils are known to be oligotrophic and of having low buffering capacities. It is expected that this is particularly the case for inland high altitude regions. We hypothesized that the bedrock type and the presence of macrobiota in these soils enforce a high selective pressure on their bacterial communities. To test this, we analysed the bacterial community structure in 52 soil samples from the western Sør Rondane Mountains (Dronning Maud Land, East Antarctica) using the Illumina MiSeq platform in combination with ARISA fingerprinting. The samples were taken along broad environmental gradients in an area covering nearly 1000 km². Ordination and variation partitioning analyses revealed that the total organic carbon content was the most significant variable in structuring the bacterial communities, followed by pH, electric conductivity, bedrock type and the moisture content, while spatial distance was of relatively minor importance. Acidobacteria (Chloracidobacteria) and Actinobacteria (Actinomycetales) dominated gneiss derived mineral soil samples, while Proteobacteria (Sphingomonadaceae), Cyanobacteria, Armatimonadetes and candidate division FBP dominated soil samples with a high total organic carbon content that were mainly situated on granite derived bedrock. [less ▲]Detailed reference viewed: 48 (6 ULg) Réparation des ouvrages en béton armé - Partie 1 : Pathologies et diagnosticCourard, Luc ; Bissonnette, Benoîtin Techniques de l'Ingénieur. Analyse Chimique et Caractérisation (2016)Repair of concrete not only requires knowledge of the support to repair, the repair materials and the environmental conditions in which they will be implemented, but also an understanding of the ... [more ▼]Repair of concrete not only requires knowledge of the support to repair, the repair materials and the environmental conditions in which they will be implemented, but also an understanding of the mechanisms underlying adhesion. Dimensional, electrochemical, chemical and porosity (permeability) compatibilities are the key to the success and durability of the repair. In a first part, an analysis of the patrimonial heritage at stake and the possible intervention strategies is proposed. The emphasis is put here on the study of the effects and causes of deterioration affecting reinforced concrete structures: cracking, spalling and disintegration are the main types surface defects observed, most often in connection with corrosion of the underlying steel reinforcement. A proper diagnosis will allow selecting the most suitable repair techniques and materials (Part 2). [less ▲]Detailed reference viewed: 40 (0 ULg) Detection of Angiostrongylus vasorum by quantitative PCR in bronchoalveolar lavage fluid in Belgian dogsCanonne-Guibert, Morgane ; Roels, Elodie ; Caron, Yannick et alin Journal of Small Animal Practice (2016), 57(3), Detailed reference viewed: 16 (9 ULg) DPP-4 inhibitor plus SGLT-2 inhibitor as combination therapy for type 2 diabetes: from rationale to clinical aspects.Scheen, André in Expert Opinion on Drug Metabolism & Toxicology (2016)INTRODUCTION: Type 2 diabetes (T2D) is a complex disease with multiple defects, which generally require a combination of several pharmacological approaches to control hyperglycemia. Combining a dipeptidyl ... [more ▼]INTRODUCTION: Type 2 diabetes (T2D) is a complex disease with multiple defects, which generally require a combination of several pharmacological approaches to control hyperglycemia. Combining a dipeptidyl peptidase-4 inhibitor (DPP-4i) and a sodium-glucose cotransporter type 2 inhibitor (SGT2i) appears to be an attractive approach. AREA COVERED: An extensive literature search was performed to analyze the pharmacokinetics, pharmacodynamics and clinical experience of different gliptin-gliflozin combinations. EXPERT OPINION: There is a strong rationale for combining a DPP-4i and a SGLT2i in patients with T2D because the two drugs exert different and complementary glucose-lowering effects. Dual therapy (initial combination or stepwise approach) is more potent than either monotherapy in patients treated with diet and exercise or already treated with metformin. Combining the two pharmacological options is safe and does not induce hypoglycemia. The additional glucose-lowering effect is more marked when a gliflozin is added to a gliptin than when a gliptin is added to a gliflozin. Two fixed-dose combinations (FDCs) are already available (saxagliptin-dapagliflozin and linagliptin-empagliflozin) and others are in current development. Bioequivalence of the two compounds given as FDC tablets was demonstrated when compared with coadministration of the individual tablets. FDCs could simplify the anti-hyperglycaemic therapy and improve drug compliance. [less ▲]Detailed reference viewed: 17 (2 ULg) An endogenous gibbon ape leukemia virus (GALV) identified in a rodent (Melomys sp.) from IndonesiaAlfano, niccolo; Michaux, Johan ; Fabre, Pierre-Henri et alin Journal of Virology (2016)Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated froma cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or moreintermediate as yet ... [more ▼]Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated froma cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or moreintermediate as yet unknown hosts. A highly similar virus to GALV has been identified in anAustralian rodent (Melomys burtoni) after extensive screening of Australian wildlife. GALV-likeviruses have also been discovered in several Southeast Asian species although screening has not beenextensive and viruses discovered to date are only distantly related to GALV. We therefore screened 26Southeast Asian rodent species for KoRV- and GALV-like sequences, using hybridization capture andhigh-throughput sequencing, in the attempt to identify potential GALV and KoRV hosts. Only onespecies, an undescribed species of Melomys from Indonesia, was positive yielding an endogenousprovirus very closely related to a strain of GALV. The sequence of the critical receptor domain forGALV infection in the Indonesian Melomys sp. was consistent with the susceptibility of the species toGALV infection. The discovery of a GALV in a second Melomys species provides further evidencethat Melomys may play a role in the spread of GALV-like viruses, especially since the genus is foundin Indonesia, Papua New Guinea and Australia, connecting the home ranges of koalas and gibbons [less ▲]Detailed reference viewed: 14 (1 ULg) Microfluidic chip with molecular beacons detects miRNAs in Human CSF to reliably characterize CNS-specific disordersZadran, S.; Remacle, Françoise ; Levine, R. D.in RNA & Disease (2016), 3Detailed reference viewed: 12 (2 ULg) Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.Bay-Jensen, A. C.; Reker, D.; Kjelgaard-Petersen, C. F. et alin Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society (2016), 24(1), 9-20OBJECTIVE: To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED ... [more ▼]OBJECTIVE: To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED criteria and set it in context of the medical needs of 2015. METHODS: PubMed was used as searching machine: Time period 2014/04/01-2015/05/01, MeSH term [Biomarker] AND [Osteoarthritis], Language; English, Full text available. Reviews were excluded. Only papers describing protein based biomarkers measured in human body fluids from OA patients were included. RESULTS: Biomarkers of joint tissue turnover, cytokines, chemokines and peptide arrays were measured in different cohorts and studies. Amongst those were previously tested biomarkers such as osteocalcin, Carboxy-terminal cross-linked fragment of type II collagen (CTX-II) and cartilage oligomeric matrix protein (COMP). A majority of the biomarker were classified as I, B or B biomarkers according to the BIPED criteria. Work is continuing on testing biomarkers in OA. There is still a huge, unmet medical need to identify, test, validate and qualify novel and well-known biomarkers. A pre-requisite for this is better characterization and classification of biomarkers to their needs, which may not be reached before higher understanding of OA phenotypes has been gained. In addition, we provide some references to some recent guidelines from Food and Drug Administration (FDA) and European Medicines Agency (EMA) on qualification and usage of biomarkers for drug development and personalized medicine, which may provide value to the field. [less ▲]Detailed reference viewed: 17 (1 ULg) Reassessment of the acrylamide risk: Belgium as a case-studyClaes, Wendie; De Meulenaer, Bruno; Huyghebaert, André et alin Food Control (2016), 59Acrylamide is a food process contaminant with carcinogenic and genotoxic properties. As a result of intensive research, numerous mitigation initiatives to prevent its formation were suggested and various ... [more ▼]Acrylamide is a food process contaminant with carcinogenic and genotoxic properties. As a result of intensive research, numerous mitigation initiatives to prevent its formation were suggested and various of them were implemented in the food chain. To evaluate if the mitigation strategies applied were significant, a comparison was made between two time periods (2002e2007 versus 2008e2013) in terms of acrylamide food levels and dietary exposure in Belgian. The most important changes observed are a significant decrease of the acrylamide content in potato crisps and gingerbread, and a significant increase in (instant) coffee. Additionally, the acrylamide content of breakfast cereals, bread and rolls, chocolate and baby biscuits showed a downward trend, whereas for coffee substitute and ready-to-eat French fries (mainly obtained from catering facilities), an upward, although not significant, trend was observed. These changes resulted in only a slight, but insignificant decline of the overall dietary exposure of adults, adolescents and children. The mean and P95 intake estimated in the 2008e2013 period for these consumer groups corresponded to margins of exposure (MOE) ranging between 515 and 236 and between 155 and 71, respectively, when based on the endpoint for neoplastic effects (BMDL10 ¼ 0.17 mg/kg bw per day). Such low MOE values indicate that acrylamide remains an issue for public concern, requiring renewed attention. [less ▲]Detailed reference viewed: 51 (4 ULg) Primary Care Physicians’ Action Plans for Answering to Results of Screening Test based on the Concept of Quaternary PreventionBae, Jong Myon; Jamoulle, Marc in Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi (2016)Since non-communicable disease (NCD) should be controllable rather than curable, more emphasis is placed on prevention, rather than on treatment. For early detection of diseases, a primary care physician ... [more ▼]Since non-communicable disease (NCD) should be controllable rather than curable, more emphasis is placed on prevention, rather than on treatment. For early detection of diseases, a primary care physician (PCP) as well as general practitioner and family physician should interpret screening results accurately and provide screenees with appropriate information of prevention and treatment including potential harms. The concept of quaternary prevention (QP), which was introduced by Jamoulle and Roland in 1995 was applied to screening results. This article summarizes situations that PCPs encounter during screening tests according to the concept of QP, and suggests measures to face such different situations. Suggestions for screening tests customized to the characteristics of individuals are substituting suggestions for screening based on guidelines. Since there are some circumstances that screening tests should not be done, further studies based on the concept of prevention level proposed by Jamoulle and Roland are required to draw various and useful prevention strategies to prevent NCDs, including cancers. Thus, applying the concept of QP helps PCPs have better insights on screening tests for preventing NCD and also contributes to improve doctor-patient relationship by helping screenees understand medical uncertainties. Key [less ▲]Detailed reference viewed: 94 (3 ULg) Characterization of brown streak virus-resistant cassava.Anjanappa, Ravi B.; Mehta, Devang; Maruthi, M. N. et alin Molecular plant-microbe interactions : MPMI (2016)Cassava brown streak disease (CBSD) has become a major constraint to cassava production in East and Central Africa. The identification of new sources of CBSD resistance is essential to deploy CBSD ... [more ▼]Cassava brown streak disease (CBSD) has become a major constraint to cassava production in East and Central Africa. The identification of new sources of CBSD resistance is essential to deploy CBSD mitigation strategies as the disease is progressing westwards to new geographical areas. A stringent infection method based on top cleft grafting combined with precise virus titer quantitation was utilized to screen fourteen cassava cultivars and elite breeding lines. When inoculated with mixed infections of Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV), the scions of elite breeding lines KBH 2006/18 and KBH 2006/26 remained symptom-free during a 16-week period of virus graft inoculation, while susceptible varieties displayed typical CBSD infection symptoms at 4 weeks after grafting. The identified CBSD resistance was stable under the co-inoculation of CBSV, UCBSV with cassava geminiviruses (CGMs). Double grafting experiments revealed that transmission of CBSV and UCBSV to CBSD susceptible top scions was delayed when using intermediate scions of elite breeding lines KBH 2006/18 and KBH 2006/26. Nonetheless, comparison of virus systemic movement using scions from KBH2006/18 and a transgenic CBSD resistant 60444 line (60444-Hp9 line) showed that both CBSV and UCBSV move at undetectable levels through the stems. Further, protoplast-based assays of virus titers showed that the replication of CBSVs is inhibited in the resistant line KBH2006/18, suggesting that the identified CBSD resistance is at least partially based on inhibition of virus replication. Our molecular characterization of CBSD resistance in cassava offers a robust virus-host system to further investigate the molecular determinants of CBSD resistance. [less ▲]Detailed reference viewed: 52 (1 ULg) Electrophoretic deposition of hydroxyapatite and hydroxyapatite– alginate on rapid prototyped 3D Ti6Al4V scaffoldsOzhukil Kollath, Vinayaraj; Chen, Qiang; Mullens, Steven et alin Journal of Materials Science (2016), 51The advantage of using bioceramic particles coated on porous three-dimensional structures is still unexplored in the purpose of improving the osteoinduction of hybrid metallic scaffold implants in vivo ... [more ▼]The advantage of using bioceramic particles coated on porous three-dimensional structures is still unexplored in the purpose of improving the osteoinduction of hybrid metallic scaffold implants in vivo. In this study, we evaluate electrophoretic deposition (EPD) to coat porous Ti6Al4V scaffolds with hydroxyapatite (HA). Scaffolds were shaped in different open structures with a horizontal shift in fiber stacking. They were produced using three-dimensional fiber deposition method and were coated by EPD with HA powder (d10 = 1.7, d50 = 5.7 and d90 = 18 lm) suspended in ethanol or butanol at different concentration, DC voltage, and time. A composite HA–alginate was also used to coat the scaffolds. Alginate was used as a binder, and the coating properties (homogeneity, thickness, cracks, continuity, etc.) were compared to coatings obtained from pure HA suspensions. Voltage and time of deposition effects were studied between 10 and 140 V and 10 and 120 s, respectively. Coating thickness and density with respect to the depth of the porous structure were studied by observing cross sections using scanning electron microscopy and image processing analysis. HA–alginate combination resulted in a homogeneous and deeper dense layer of HA. This work also points to the characteristics of HA–alginate composite as a superior alternative to pure HA coating which needs an appropriate thermal treatment for adequate substrate adhesion. [less ▲]Detailed reference viewed: 36 (6 ULg) About the Uniform Hölder Continuity of Generalized Riemann FunctionBastin, Françoise ; Nicolay, Samuel ; Simons, Laurent in Mediterranean Journal of Mathematics (2016), 13(1), 101-117In this paper, we study the uniform H\"{o}lder continuity of the generalized Riemann function~$R_{\alpha,\beta}$ (with $\alpha>1$ and $\beta>0$) defined by $R_{\alpha,\beta}(x)=\sum_{n=1}^{+\infty}\frac ... [more ▼]In this paper, we study the uniform H\"{o}lder continuity of the generalized Riemann function~R_{\alpha,\beta} (with \alpha>1 and \beta>0) defined by \[ R_{\alpha,\beta}(x)=\sum_{n=1}^{+\infty}\frac{\sin(\pi n^\beta x)}{n^\alpha},\quad x\in\mathbb{R},$ using its continuous wavelet transform. In particular, we show that the exponent we find is optimal. We also analyse the behaviour of~$R_{\alpha,\beta}$ as $\beta$ tends to infinity. [less ▲]Detailed reference viewed: 53 (16 ULg) Editorial.Demeuse, Marc; Fagnant, Annick in Evaluer : Journal International de Recherche en Education et Formation (2016), 2(1), 5-6Detailed reference viewed: 10 (0 ULg) Tests of a new drowsiness characterization and monitoring system based on ocular parametersFrançois, Clémentine ; Hoyoux, Thomas ; Langohr, Thomas et alin International Journal of Environmental Research and Public Health (2016)Detailed reference viewed: 33 (15 ULg) The Taste of the Eye and the Sight of the Tongue. The Relations Between Sight and Taste in Early Modern EuropeVon Hoffmann, Viktoria in Senses and Society (The) (2016), 11 (2016)(2), 83-113This article examines the articulation between the senses of taste and sight through the representations of their organs, the tongue and the eye, in early modern Europe. The relationship between taste and ... [more ▼]This article examines the articulation between the senses of taste and sight through the representations of their organs, the tongue and the eye, in early modern Europe. The relationship between taste and sight first brings to mind gastronomical aesthetics, and the part played by the eye in the relish of beautifully presented dishes. The first part of this article is therefore devoted to exploring the taste of the eye (or the foretaste of sight) and highlights the harmony of taste and sight in early modern cuisine. However, the forms of reciprocity between taste and sight cannot be reduced to the sole figure of culinary aesthetics, which tends to blur the other multiple modalities that this sensorial association could reveal. The second part, the sight of the tongue (or the invisibility of taste), thus examines more complex layers of the relationship between the sense of sight and the taste organ, through a study of the representations of the tongue and of the gaping mouth in early modern visual culture. Drawing on early modern textual and iconographic resources and exploring: cookbooks; physiognomic works; conduct books; and also engravings and paintings related to the culinary arts, the seven deadly sins, and representations of madness and the fool in early modern visual culture, this essay argues that examining the representations of the sense organs is a suggestive way to explore the relationship between the senses. [less ▲]Detailed reference viewed: 23 (2 ULg) Clinical trials of new drugs for the treatment of rheumatoid arthritis: focus on early diseaseSMOLEN, J.S.; COLLAUD BASSET, S.; BOERS, M. et alin Annals of Rheumatic Diseases (2016), 75The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases convened a task force of experts in rheumatoid arthritis (RA) and clinical trial ... [more ▼]The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases convened a task force of experts in rheumatoid arthritis (RA) and clinical trial methodology to comment on the new draft ‘Guideline on clinical investigation of medicinal products for the treatment of RA’ released by the European Medicines Agency (EMA). Special emphasis was placed by the group on the development of new drugs for the treatment of early RA. In the absence of a clear definition of early RA, it was suggested that clinical investigations in this condition were conducted in disease-modifying antirheumatic drugs naïve patients with no more than 1 year disease duration. The expert group recommended using an appropriate improvement in disease activity (American College of Rheumatology (ACR) or Simplified/Clinical Disease Activity Index (SDAI/CDAI) response criteria) or low disease activity (by any score) as primary endpoints, with ACR/European League Against Rheumatism remission as a secondary endpoint. Finally, as compelling evidence showed that the Disease Acrivity Score using 28-joint counts (DAS28) might not provide a reliable definition of remission, or sometimes even low disease activity, the group suggested replacing DAS28 as a measurement instrument to evaluate disease activity in RA clinical trials. Proposed alternatives included SDAI, CDAI and Boolean criteria. [less ▲]Detailed reference viewed: 30 (8 ULg) La ruine d'une compagnie d'assurances : un événement qu'on aimerait éviterEsch, Louis in Tangente (2016), HS 57Detailed reference viewed: 2 (0 ULg) The Flemish Lion Singing: Community imagination and historical legitimisation of nationalism at the 76th Flemish National Song FestivalMazzola, Alessandro in Music and Arts in Action (2016), 5(2), Detailed reference viewed: 21 (2 ULg) Fe3+/Iron Oxide/SiO2 Xerogel Catalysts for p-nitrophenol Degradation by Photo-Fenton Effects: Influence of Thermal Treatment on Catalysts TextureMahy, Julien ; Tasseroul, Ludivine ; Herlitscke, Marcus et alin Materials Today: Proceedings (2016), 3(2), 464-469Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ... [more ▼]Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ions. Four thermal treatments were applied to catalysts: drying, drying-autoclaving, calcination and calcination-autoclaving. Textural characterizations show that the specific surface area is increased by calcination while materials microporosity completely collapse when using autoclaving. Based on Mössbauer spectroscopy and magnetometry measurements, only Fe3+ species were observed in xerogel catalysts. The photo-Fenton effect of these catalysts was evaluated on the degradation of p-nitrophenol in aqueous media. In the presence of H2O2, results show that this effect reachs 99% of degradation after 24 h. Mössbauer and catalytic tests are presented in another paper. [less ▲]Detailed reference viewed: 63 (33 ULg) Trophic ecology of the seagrass-inhabiting footballer demoiselle Chrysiptera annulata (Peters, 1855); comparison with three other reef-associated damselfishesLepoint, Gilles ; Michel, Loïc ; Parmentier, Eric et alin Belgian Journal of Zoology (2016), 146(1), 21-32Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming ... [more ▼]Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming behavior, from almost non territorial to monoculture farmers. In addition, few species inhabit seagrass meadows but, presently, none can be considered as seagrass-eating specialists. The footballer demoiselle, Chrysiptera annulata, is found in the seagrass meadows on the reef flat of the Great Reef of Toliara (Madagascar, Mozambique Channel). Regarding this unusual habitat for pomacentrid, this study aimed to answer 3 questions: 1) What is the diet of C. annulata? 2) Do the resources supporting this diet include seagrass? 3) Does its trophic niche overlap those of other sympatric damselfishes (Pomacentrus trilineatus, Chrysiptera unimaculata and Plectroglyphidodon lacrymatus) living in close association with macrophytes or eating algae? Stomach content examination and stable isotope analysis showed that the footballer demoiselle is not a seagrass consumer but is an omnivorous/herbivorous species heavily relying on algal resources and small invertebrates. SIAR, a stable isotope mixing model, indicated it assimilated large amount of turf algae and various benthic or planktonic invertebrates in lower proportions. SIBER metrics pointed out that isotopic niche of the footballer demoiselle partly overlaps the one of its congeneric C. unimaculata, but not those of P. trilineatus and P. lacrymatus. Trophic strategies of C. annulata differed both from farming species such as P. lacrymatus or from less territorial herbivores such as P. trilineatus. Its seagrass meadow habitat on the Great Reef of Toliara allow the conquest of an unusual habitat for damselfishes and could limit competition with C. unimaculata, a species displaying the same territorial behavior and the same isotopic niche but living on the reef itself. [less ▲]Detailed reference viewed: 79 (18 ULg) Chemical composition of essential oils and floral waters of Mentha longifolia (L.) Huds. from SenegalDiop, Serigne Mbacké; Guèye, Momar Talla; Ndiaye, Ibrahima et alin American Journal of Essential Oils and Natural Products (2016), 4(1), 46-49Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively ... [more ▼]Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively. Analysis of the essential oils, floral waters and the assay of pulegone were carried out by GC/FID and GC/MS. The major compounds identified in the oils were pulegone (52.0 and 42.4%), menthone (14.3 and 21.2%), 1, 8-cineole (13.1 and 11.4%) and isomenthone (9.0 and 13.2%) in the fresh and dried plants, respectively. Analyses revealed that floral waters were also characterized by the same major compounds as essential oils but at different rates. In these floral waters, pulegone constituted 60.2 and 47.0%, 1,8- cineole 7.9 and 19.6%, isomenthone 7.2 and 10.7%, menthone 6.4 and 9.2%, chrysanthenone 6.4 and 3.2% and α-terpineol 3.0 and 2.7% in the fresh and dried plants, respectively. The assay results of pulegone, a hepatotoxic compound, have shown very high levels (444.6 and 393.3mg/g) in both fresh and dried plants. [less ▲]Detailed reference viewed: 33 (4 ULg) Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH cells.Rotondi, Sandra; Modarelli, Alessio; Oliva, Maria-Antonietta et alin Molecular and cellular endocrinology (2016)PURPOSE: To search for a possible role of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha), a molecular partner of the Aryl hydrocarbon receptor Interacting Protein (AIP), in somatotropinomas ... [more ▼]PURPOSE: To search for a possible role of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha), a molecular partner of the Aryl hydrocarbon receptor Interacting Protein (AIP), in somatotropinomas. METHODS: Tumours from 51 acromegalic patients were characterized for PPARalpha and AIP expression by immunohistochemistry (IHC) and/or Real Time RT-PCR. Data were analysed according to tumour characteristics and pre-operative treatment with somatostatin analogues (SSA). The effects of fenofibrate were studied in GH3 cells in vitro. RESULTS: PPARalpha was expressed in most somatotropinomas. A modest relationship was found between PPARalpha and AIP expression, both being significantly higher in the presence of pre-operative SSA. However, only AIP expression was influenced by the response to treatment. Dual effects of fenofibrate were observed in GH3 cells, consisting of cell growth inhibition and an increase in GH secretion inhibited by octreotide. CONCLUSIONS: PPARalpha is a new player in somatotropinomas. Potential interactions between PPARalpha agonists and SSA may deserve further investigation. [less ▲]Detailed reference viewed: 21 (5 ULg) Towards sustainable food systems: the concept of agroecology and how it questions current research practices. A reviewHatt, Séverin ; Artru, Sidonie ; Brédart, David et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(Special issue 1), 215-224Introduction. Multiple environmental and socio-economic indicators show that our current agriculture and the organization of the food system need to be revised. Agroecology has been proposed as a ... [more ▼]Introduction. Multiple environmental and socio-economic indicators show that our current agriculture and the organization of the food system need to be revised. Agroecology has been proposed as a promising concept for achieving greater sustainability. This paper offers an overview and discussion of the concept based on existing literature and case studies, and explores the way it questions our current research approaches and education paradigms. Literature. In order to improve the sustainability of agriculture, the use of external and chemical inputs needs to be minimized. Agroecological farming practices seek to optimize ecological processes, thus minimizing the need for external inputs by providing an array of ecosystem services. Implementing such practices challenges the current structure of the food system, which has been criticized for its lack of social relevance and economic viability. An agroecological approach includes all stakeholders, from field to fork, in the discussion, design and development of future food systems. This inclusion of various disciplines and stakeholders raises issues about scientists and their research practices, as well as about the education of the next generation of scientists. Conclusions. Agroecology is based on the concept that agricultural practices and food systems cannot be dissociated because they belong to the same natural and socio-economic context. Clearly, agroecology is not a silver-bullet, but its principles can serve as avenues for rethinking the current approaches towards achieving greater sustainability. Adapting research approaches in line with indicators that promote inter- and transdisciplinary research is essential if progress is to be made. [less ▲]Detailed reference viewed: 108 (26 ULg) 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).Galie, Nazzareno; Humbert, Marc; Vachiery, Jean-Luc et alin European heart journal (2016), 37(1), 67-119Detailed reference viewed: 34 (0 ULg) Synthesis of hydrophilic CuInS2/ZnS quantum dots with different polymeric shells and study of their cytotoxicity and hemocompatibilitySperanskaya, Elena Sergeevna; Sevrin, Chantal ; De Saeger, Sarah et alin ACS Applied Materials and Interfaces (2016), 6Detailed reference viewed: 31 (8 ULg) Lumbopelvic motor control and low back pain in elite soccer players: a cross-sectional studyGROSDENT, Stéphanie ; Demoulin, Christophe ; Rodriguez de la Cruz, Carlos et alin Journal of Sports Sciences (2016)This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1 ... [more ▼]This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1.4 years) filled in questionnaires related to low back pain and attended a session to assess lumbopelvic motor control by means of five tests (the bent knee fall out test, the knee lift abdominal test, the sitting knee extension test, the waiter ’ s bow and the transversus abdominis test). A physiotherapist, blinded to the medical history of the participants, scored (0 = failed, 1 = correct) the performance of the players for each of the tests resulting in a lumbopelvic motor control score ranging from 0 to 5. Forty-seven per cent of the soccer players reported a disabling low back pain episode lasting at least two consecutive days in the previous year. These players scored worse lumbopelvic motor control than players without a history of low back pain (lumbopelvic motor control score of 1.8 vs. 3.3, P < 0.01). The between-groups difference was particularly marked for the bent knee fall out test, the knee lift abdominal test and the transversus abdominis test (P < 0.01). In conclusion, most soccer players with a history of low back pain had an altered lumbopelvic motor control. Further research should examine whether lumbopelvic motor control is etiologically involved in low back pain episodes in soccer players. [less ▲]Detailed reference viewed: 54 (19 ULg) Guiana Dolphins (Sotalia guianensis) and DR-CALUX for Screening Coastal Brazilian Environments for Dioxins and Related CompoundsDorneles, Paulo; Lailson-Brito, Jose; Bisi, Tatiana et alin Archives of Environmental Contamination & Toxicology (2016)Guiana dolphin is the top predator of highest toxicological concern in Brazil and many studies on levels of persistent, bioaccumulative, and toxicant (PBT) pollutants have been performed on the species ... [more ▼]Guiana dolphin is the top predator of highest toxicological concern in Brazil and many studies on levels of persistent, bioaccumulative, and toxicant (PBT) pollutants have been performed on the species. However, due to high costs of the analyses, only one investigation comprised the determination of dioxins and related compounds (DRCs) in Guiana dolphin tissues. The dioxin responsive-chemically activated luciferase gene expression (DR-CALUX ) cell bioassay was used in the present study for the analyses of hepatic samples from 28 male Guiana dolphins in order to screen estuarine environments for DRCs, comprising three regions (Northeastern, Southeastern, and Southern) and four states [Parana´ (PR), Rio de Janeiro (RJ), Espı´rito Santo (ES), and Ceara´ (CE)] of Brazil. High bioanalytical equivalent (BEQ) concentrations [dioxins (pg BEQ/g lipid)] were found, varying from 1.94 to 15.6 pg BEQ/g. A significant negative correlation between BEQ concentrations and total length was found in Guiana dolphins from Brazil (all analysed dolphins). This pattern also was verified for RJ state, pointing to (1) chemically induced developmental disruption or to (2) increasing efficiency of the detoxifying activity with the growth of the animal. Comparison was performed with literature data and significantly higher BEQ levels were found in Brazilian Guiana dolphins than in those reported for North Sea harbour porpoises. Higher levels were found in Southeastern (the most PBT-contaminated area of the country) than in Southern region. However, it is not possible to affirm that Guiana dolphins are more contaminated by DRCs in SE than in S region, because individuals were lengthier in S than in SE region. Our results seem to have mirrored dolphin exposure to PCBs in Brazil according to the literature. Further studies are required for investigating the hypotheses 1 and 2 mentioned above. [less ▲]Detailed reference viewed: 72 (8 ULg) Searching for consensus among physicians involved in the management of sick-listed workers in the Belgian health care sector: a qualitative study among practitioners and stakeholdersVanmeerbeek, Marc ; Govers, Patrick ; Schippers, Nathalie et alin BMC Public Health (2016), 16Background In Belgium, the management of sick leave involves general practitioners (GPs), occupational health physicians (OPs) and social insurance physicians (SIPs). A dysfunctional relationship among ... [more ▼]Background In Belgium, the management of sick leave involves general practitioners (GPs), occupational health physicians (OPs) and social insurance physicians (SIPs). A dysfunctional relationship among these physicians can impede a patient’s ability to return to work. The objective of this study was to identify ways to improve these physicians’ mutual collaboration. Methods Two consensus techniques were successively performed among the three professional groups. Eight nominal groups (NGs) gathered 74 field practitioners, and a two-round Delphi process involved 32 stakeholders. Results From the results, it appears that two areas (reciprocal knowledge and evolution of the legal and regulatory framework) are objects of consensus among the three medical group that were surveyed. Information transfer, particularly electronic transfer, was stressed as an important way to improve. The consensual proposals regarding interdisciplinary collaboration indicate specific and practical changes to be implemented when professionals are managing workers who are on sick leave. The collaboration process appeared to be currently more problematic, but the participants correctly identified the need for common training. Conclusions The three physician groups all agree regarding several inter-physician collaboration proposals. The study also revealed a latent conflict situation among the analysed professionals that can arise from a lack of mutual recognition. Practical changes or improvements must be included in an extended framework that involves the different determinants of interdisciplinary collaboration that are shown by theoretical models. Collaboration is a product of the actions and behaviours of various partners, which requires reciprocal knowledge and trust; collaboration also implies political and economic structures that are led by public health authorities. [less ▲]Detailed reference viewed: 29 (6 ULg) Determination of total phenolic compounds content and antioxidant activity in cherry species and cultivarsPissard, Audrey; Lateur, Marc; Baeten, V et alin Journal of Berry Research (2016)BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound ... [more ▼]BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound (TPC) content and the antioxidant capacity (AC) of a large range of cultivars using the same methodology in one laboratory, and (ii) determine the possible relationship between agronomic characteristics and AC. METHODS: A total of 245 samples including sweet, sour and hybrid cultivars from our collections were harvested at their optimum maturity and characterized according to their TPC, DPPH and ORAC values. RESULTS: The TPC content and DPPH and ORAC values varied greatly among the cherries, with the sour cultivars presenting higher levels than the sweet ones. The PCA plot showed a slight grouping by species and confirmed the high TPC content level in sour cultivars. The bi-colored cultivars had lower TPC and antioxidant capacity (AC) values than dark-colored ones, indicating that coloration could give an indication of the AC of fruits. No significant relationship between the agronomic and chemical properties was highlighted. CONCLUSIONS: Cherry fruits, especially from sour cultivars, represent an important source of bioactive compounds and could attract new interest as a ‘functional food’. [less ▲]Detailed reference viewed: 64 (28 ULg) A comparison of a tablet version of the Quality of Life Systemic Inventory for Children (QLSI-C) to the standard paper versionToucheque, Malorie ; Etienne, Anne-Marie ; Missotten, Pierre et alin Psychological Assessment (2016), 28(6), 780-785Integration of e-Health technologies for purposes of both assessment and intervention has recently become an interest area in pediatric psychology. The purpose of this study is to present psychometric ... [more ▼]Integration of e-Health technologies for purposes of both assessment and intervention has recently become an interest area in pediatric psychology. The purpose of this study is to present psychometric characteristics of a technology-based (i.e., tablet administration) approach for measuring quality of life (QOL) in children. Eighty children (8-12 years) completed the Quality of Life Systemic Inventory for Children (QLSI-C) twice over a two-week delay, in a crossover design that used paper and tablet-based modes of administration. Equivalence of scores across methods was examined using Intraclass correlation coefficients (ICC), augmented by paired t-test and Pearson’s correlations. Test-retest reliability was assessed using paired t-test and Pearson’s correlations while internal consistency was assessed using Cronbach’s coefficient. Results showed a good concordance across methods of administration (ICCs = .72 to .91; r = .56 to .83). Paired t-test showed no significant differences between the tablet and paper version of the QLSI-C. Internal consistency reliability yielded acceptable Cronbach’s alphas for all QLSI-C scores, with all α >.70. Test-retest reliability for the tablet-administered QLSI-C was good (r = .66 to .90). Paired t-test showed no significant difference between time 1 and 2 for the QLSI-C scores, except for the state score. Findings established the reliability of the tablet-administered QLSI-C scores. This technology approach to assessment is more attractive for children, decreases time for administration, and enhances the ease of scoring. These advantages might encourage both clinicians and researchers to consider using e-Health developments in assessment in pediatric psychology. [less ▲]Detailed reference viewed: 78 (14 ULg) High Temperature Ferromagnetism in a GdAg2 MonolayerOrmaza, M.; Fernandez, L.; Ilyn, M. et alin Nano Letters (2016), 0(0), Detailed reference viewed: 47 (3 ULg) A general parametric Stein characterizationLey, Christophe; Swan, Yvik in Statistics & Probability Letters (2016), 111Detailed reference viewed: 31 (2 ULg) Isolation and characterization of Ts19 Fragment II, a new long-chainpotassium channel toxin from Tityus serrulatus venomCerni, Felipe Augusto; Pucca, Manuela Berto; Amorim, Fernanda Gobbi et alin Peptides (2016), 80Ts19 Fragment II (Ts19 Frag-II) was first isolated from the venom of the scorpion Tityus serrulatus (Ts). It is aprotein presenting 49 amino acid residues, three disulfide bridges, Mr5534 Da and was ... [more ▼]Ts19 Fragment II (Ts19 Frag-II) was first isolated from the venom of the scorpion Tityus serrulatus (Ts). It is aprotein presenting 49 amino acid residues, three disulfide bridges, Mr5534 Da and was classified as a newmember of class (subfamily) 2 of the -KTxs, the second one described for Ts scorpion. The -KTx familyis composed by two-domain peptides: N-terminal helical domain (NHD), with cytolytic activity, and aC-terminal CS domain (CCD), with Kv blocking activity. The extensive electrophysiological screening(16 Kv channels and 5 Nav channels) showed that Ts19 Frag-II presents a specific and significant blockingeffect on Kv1.2 (IC50value of 544 ± 32 nM). However, no cytolytic activity was observed with this toxin.We conclude that the absence of 9 amino acid residues from the N-terminal sequence (compared to Ts19Frag-I) is responsible for the absence of cytolytic activity. In order to prove this hypothesis, we synthesizedthe peptide with these 9 amino acid residues, called Ts19 Frag-III. As expected, Ts19 Frag-III showed tobe cytolytic and did not block the Kv1.2 channel. The post-translational modifications of Ts19 and itsfragments (I–III) are also discussed here. A mechanism of post-translational processing (post-splitting) issuggested to explain Ts19 fragments production. In addition to the discovery of this new toxin, this reportprovides further evidence for the existence of several compounds in the scorpion venom contributing tothe diversity of the venom arsenal. [less ▲]Detailed reference viewed: 18 (3 ULg) Gender effect on the scapular 3D posture and kinematic in healthy subjectsSchwartz, Cédric ; Croisier, Jean-Louis ; Rigaux, Elise et alin Clinical Physiology and Functional Imaging (2016)Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However ... [more ▼]Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However the literature reports, for the shoulder, differences in the range of motion between genders. The specific influence of gender on the scapula-thoracic kinematics has not been studied yet. The dominant shoulder of two populations of men and women composed of 11 subjects each were evaluated in three dimensions for three distinct motions: flexion in the sagittal plane, abduction in the frontal plane and gleno-humeral internal/external rotation with the arm abducted at 90°. Posture, kinematics and range of motion were studied separately. For flexion and abduction and with regard to the scapular kinematic, external rotation were significantly larger for women than men. The differences were of at least 5° at 120° of humeral elevation. Upward rotations were identical. Women also showed larger average active humero-thoracic range of motion. The mean differences were of 13°, 7°, 12° and 5° for abduction, flexion, internal rotation and external rotation, respectively. No difference was observed between the scapular resting positions of both populations. The observed differences concerning both the scapular and humeral patterns would indicate that the shoulder behavior of men and women should not be expected to be similar. [less ▲]Detailed reference viewed: 117 (36 ULg) Migration, prostitution and the representation of the black female subject in Nigerian video films about ItalyJedlowski, Alessandro in Journal of Italian Cinema and Media Studies (2016), 4(1), 9-23Much contemporary images of black women in Italian media are marked by the legacy of colonialist propaganda and tend to perpetuate a representation of black women as passive eroticized objects of the ... [more ▼]Much contemporary images of black women in Italian media are marked by the legacy of colonialist propaganda and tend to perpetuate a representation of black women as passive eroticized objects of the white male gaze. In this sense, Ponzanesi’s call for ‘new and less biased representations, which could help to assess the multiple subject positions that black identities now occupy’ (2005: 179) is still relevant. This article responds to this call by analyzing two Nigerian video films that thematize migration and prostitution trafficking in Italy. By highlighting the complexity of the processes of ‘subjectivation’ taking place throughout the migratory process, these videos invite their viewers to look at the postcolonial subject’s responsibility in shaping the world in which s/he lives, and offer a representation of the black female subject able to go beyond the voyeuristic attitude that characterize much of the existing contemporary Italian visual culture about this topic. [less ▲]Detailed reference viewed: 134 (2 ULg) The Role of Post-Translational Modifications in Hearing and DeafnessMateo Sanchez, Susana ; Freeman, Stephen ; Delacroix, Laurence et alin Cellular and Molecular Life Sciences : CMLS (2016)Post-translational modifications (PTMs) are key molecular events that modify proteins after their synthesis and modulate their ultimate functional properties by affecting their stability, localisation ... [more ▼]Post-translational modifications (PTMs) are key molecular events that modify proteins after their synthesis and modulate their ultimate functional properties by affecting their stability, localisation, interaction potential or activity. These chemical changes expand the size of the proteome adding diversity to the molecular pathways governing the biological outcome of cells. PTMs are thus crucial in regulating a variety of cellular processes such as apoptosis, proliferation and differentiation and have been shown to be instrumental during embryonic development. In addition, alterations in protein PTMs have been implicated in the pathogenesis of many human diseases, including deafness. In this review, we summarize the recent progress made in understanding the roles of PTMs during cochlear development, with particular emphasis on the enzymes driving protein phosphorylation, acetylation, methylation, glycosylation, ubiquitination and SUMOylation. We also discuss how these enzymes may contribute to hearing impairment and deafness. [less ▲]Detailed reference viewed: 26 (7 ULg) Targeted control of the saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), and the benefits of good control of this pest to winter wheat yieldCensier, Florence ; Chavalle, Sandrine ; San Martin y Gomez, Gilles et alin Pest Management Science (2016)BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe ... [more ▼]BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe damage in cereals. In 2012 and 2013, field trials were conducted in heavily infested fields to assess its impact on winter wheat crops and to determine efficient ways of dealing with severe infestations. RESULTS: Crop exposure to H. marginata varied with the different protection methods tried. These methods included one to four successive applications of lambda-cyhalothrin. Yield losses were significant, reaching 6% in 2012 and as high as 15% in 2013, and these losses were linearly related to the number of galls on stems. CONCLUSION: The trials showed that insecticide applications needed to be synchronized with H. marginata flight peaks and to target the egg hatching period. They also revealed that insecticides applied to coincide with the first flight could, in humid conditions, also reach the larvae close to the soil surface, prior to their pupation. [less ▲]Detailed reference viewed: 66 (15 ULg) Human norovirus infection in Latin Americada Silva Polo, Tatiane; Peiro, Juliana; Claudio Nogueira Mendes, Luiz et alin Journal of Clinical Virology (2016), 78Detailed reference viewed: 10 (3 ULg) Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY*Sautrey, Guillaume; El Khoury, Micheline; Dos Giros, Andrea et alin Journal of Biological Chemistry (2016)Detailed reference viewed: 24 (8 ULg) Invading or recolonizing? Patterns and drivers of wild boar population expansion into Belgian agroecosystemsMorelle, Kévin; Fattebert, Julien; Mengal, Coralie et alin Agriculture, Ecosystems & Environment (2016), 222Native species can also exhibit invasive-like spreading patterns, and identifying mechanisms driving spread of native species is a recent but essential challenge in ecology. In Europe, wild boar Sus ... [more ▼]Native species can also exhibit invasive-like spreading patterns, and identifying mechanisms driving spread of native species is a recent but essential challenge in ecology. In Europe, wild boar Sus scrofa populations and range increased for decades. While patterns of population growth are well studied, those related to range expansion are still poorly understood. In this study, we aimed to understand patterns and mechanisms that promoted wild boar population expansion in agricultural landscapes of Southern Belgium between 1981 and 2010. Using hunting-based knowledge on colonization history and an information-theoretic approach, we evaluated support to four a priori hypotheses explaining mechanisms of wild boar colonisation in an agro-ecosystem: natural forested landscape as recolonization mechanism, and cultivated landscape, propagule pressure and climate change as invasion mechanisms. We found that wild boar population expansion in Belgian agroecosystems was a relatively slow process driven by the natural landscape, propagule pressure, and climatic changes. This suggests a combination of invasive and recolonization mechanisms was in play in the expansion of wild boar over the last three decades. Our study provides insights in the mechanisms that enable the species’ recovery in Europe since the mid-20th century, and underline the need for adapted management strategies taking into account the invasive components of wild boar population expansion. [less ▲]Detailed reference viewed: 10 (2 ULg) Giving meaning to illness: an investigation of self-defining memories in patients with multiple sclerosisVoltzenlogel, Virginie; Ernst, Alexandra ; De Seze, Jérôme et alin Consciousness & Cognition (2016)Detailed reference viewed: 9 (1 ULg) Energy and nutrient content of food served and consumed by nursing home residentsBuckinx, Fanny ; ALLEPAERTS, Sophie ; PAQUOT, Nicolas et alin the journal of nutrition, health & aging (2016), in pressObjective: The aim of this study was to compare energy and protein content of the served food with the actual intake from the food consumed by nursing home residents. This study also aimed to compare food ... [more ▼]Objective: The aim of this study was to compare energy and protein content of the served food with the actual intake from the food consumed by nursing home residents. This study also aimed to compare food intake and dietary allowances. Design: This is a cross sectional study. Setting: This study was performed in nursing homes. Participants: Residents of these 2 nursing homes were eligible for the study if they agreed to participate and if they meet the selection criteria (to be older than 65 years and have a regular texture diet). Measurement: Nutrient content of the served food and real food consumption was calculated for all meals during a 5-day period by precise weighting method. Difference between consumed and served dietary content was evaluated by the Chi² test. Results: Seventy-four Belgian nursing home residents (75% of women, 85.8 ± 7.04 years on average) were included in this study. These subjects had a mean body mass index of 24.9 ± 4.83 kg/m². The mean energy content of the served food was 1783.3 ± 125.7 kcal per day. However, residents did not eat the whole of the meals and the actual energy content of the consumed food was significantly less (1552.4 ± 342.1 kcal per day; p<.001). The average protein content of the food served was equal to 0.96 ± 0.20 g/kg/day and the average consumption of protein by the residents was 0.88 ± 0.25 g/kg/day. The difference between protein served and consumed was also significant (p=.04). Moreover, people considered as well nourished, eating significantly more energy than the others (p=.04). Conclusion: Meals served in nursing homes are not entirely consumed by their residents. As expected, the energy consumed are lower in subjects considered as malnourished or at risk of malnutrition. [less ▲]Detailed reference viewed: 13 (2 ULg) Real-time remedial action against aperiodic small signal rotor angle instabilityWeckesser, Johannes ; Jóhannsson, Hjörtur; Østergaard, Jacobin IEEE Transactions on Power Systems (2016), 31(1), 387-396This paper presents a method that in real-time determines remedial actions, which restore stable operation with respect to aperiodic small signal rotor angle stability (ASSRAS) when insecure or unstable ... [more ▼]This paper presents a method that in real-time determines remedial actions, which restore stable operation with respect to aperiodic small signal rotor angle stability (ASSRAS) when insecure or unstable operation has been detected. An ASSRAS assessment method is used to monitor the stability boundary for each generator in real-time. The ASSRAS boundary represents the condition when a generator reaches the maximum steady state active power injection. The proposed control method exploits analytically derived expressions for the ASSRAS boundary and other characteristic curves in the injection impedance plane to determine an active power redispatch among selected generators to restore stable and secure operation. Since the method is purely based on analytically derived expression, the computation of the remedial actions is fast and well suited for real-time operation. The method was tested on the IEEE 14-bus and the Nordic32 test systems where results show that the method can efficiently determine the required active power redispatch to avoid an imminent instability. [less ▲]Detailed reference viewed: 9 (0 ULg) Correlation between resting state fMRI total neuronal activity and PET metabolism in healthy controls and patients with disorders of consciousnessSoddu, Andrea ; Gomez, Francisco; Heine, Lizette et alin Brain and Behavior (2016)Introduction: The mildly invasive 18F-ﬂuorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure ‘resting state’ cerebral metabolism. This technique made ... [more ▼]Introduction: The mildly invasive 18F-ﬂuorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure ‘resting state’ cerebral metabolism. This technique made it possible to assess changes in metabolic activity in clinical applications, such as the study of severe brain injury and disorders of consciousness. Objective: We assessed the possi- bility of creating functional MRI activity maps, which could estimate the rela- tive levels of activity in FDG-PET cerebral metabolic maps. If no metabolic absolute measures can be extracted, our approach may still be of clinical use in centers without access to FDG-PET. It also overcomes the problem of recogniz- ing individual networks of independent component selection in functional mag- netic resonance imaging (fMRI) resting state analysis. Methods: We extracted resting state fMRI functional connectivity maps using independent component analysis and combined only components of neuronal origin. To assess neu- ronality of components a classiﬁcation based on support vector machine (SVM) was used. We compared the generated maps with the FDG-PET maps in 16 healthy controls, 11 vegetative state/unresponsive wakefulness syndrome patients and four locked-in patients. Results: The results show a signiﬁcant similarity with q = 0.75  0.05 for healthy controls and q = 0.58  0.09 for vegetative state/unresponsive wakefulness syndrome patients between the FDG- PET and the fMRI based maps. FDG-PET, fMRI neuronal maps, and the conjunction analysis show decreases in frontoparietal and medial regions in vegetative patients with respect to controls. Subsequent analysis in locked-in syndrome patients produced also consistent maps with healthy controls. Conclusions: The constructed resting state fMRI functional connectivity map points toward the possibility for fMRI resting state to estimate relative levels of activity in a metabolic map. [less ▲]Detailed reference viewed: 76 (14 ULg) Bacterial and eukaryotic biodiversity patterns in terrestrial and aquatic habitats in the 1 Sør Rondane Mountains, Dronning Maud Land, East AntarcticaObbels, Dagmar; Verleyen, Elie; Mano, Marie-José et alin FEMS Microbiology Ecology (2016), 92The bacterial and microeukaryotic biodiversity were studied using pyrosequencing analysis on a 454 GS FLX+ platform of partial SSU rRNA genes in terrestrial and aquatic habitats of the Sør Rondane ... [more ▼]The bacterial and microeukaryotic biodiversity were studied using pyrosequencing analysis on a 454 GS FLX+ platform of partial SSU rRNA genes in terrestrial and aquatic habitats of the Sør Rondane Mountains, including soils, on mosses, endolithic communities, cryoconite holes and supraglacial and subglacial meltwater lenses. This inventory was complemented with Denaturing Gradient Gel Electrophoresis targeting Chlorophyta and Cyanobacteria. OTUs belonging to the Rotifera, Chlorophyta, Tardigrada, Ciliophora, Cercozoa, Fungi, Bryophyta, Bacillariophyta, Collembola and Nematodawere present with a relative abundance of at least 0.1% in the eukaryotic communities. Cyanobacteria, Proteobacteria, Bacteroidetes, Acidobacteria, FBP and Actinobacteria were the most abundant bacterial phyla. Multivariate analyses of the pyrosequencing data revealed a general lack of differentiation of both eukaryotes and prokaryotes according to habitat type. However, the bacterial community structure in the aquatic habitats was dominated by the filamentous cyanobacteria Leptolyngbya and appeared to be significantly different compared with those in dry soils, on mosses, and in endolithic habitats. A striking feature in all datasets was the detection of a relatively large amount of sequences new to science, which underscores the need for additional biodiversity assessments in Antarctic inland locations. [less ▲]Detailed reference viewed: 30 (8 ULg) Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure.van Hemmen, J.; Saris, I. M. J.; Cohen-Kettenis, P. T. et alin Cerebral cortex (New York, N.Y. : 1991) (2016)Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the ... [more ▼]Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extended WM regions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation of WM microstructure, although sex chromosome genes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role. [less ▲]Detailed reference viewed: 17 (0 ULg) L'atlas à l'épreuve de l'image en mouvement (Warburg, Farocki, Didi-Huberman)Hagelstein, Maud ; Hamers, Jérémy in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2016)Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes ... [more ▼]Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes pour grandes personnes (G. Didi-Huberman, A. Gisinger, 2012), composée pour partie d’images en mouvement, à la pensée de la table warburgienne comme lieu d’une perpétuelle reconfiguration et d’une nouvelle lisibilité du monde. Se pourrait-il en effet qu’une image en mouvement, prise d’ordinaire dans un continuum clos, se dote, à travers le montage, des mêmes potentialités critiques – c’est-à-dire d’un même pouvoir inquiétant – que l’image fixe offerte au déambulateur de l’atlas ? [less ▲]Detailed reference viewed: 116 (10 ULg) Evaluation of a New Method for the Treatment of Invasive, Diffuse, and Unexcisable Lymphangiomas of the Oral Cavity with Defocus CO2 Laser Beam: A 20-Year Follow-UpNamour, Samir ; VAN HEUSDEN, Alain ; Namour, Amaury et alin Photomedicine and Laser Surgery (2016), 34(2), 82-87Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and ... [more ▼]Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and unexcisable oral lymphangiomas. Background data: Cystic lymphatic malformations, or lymphangiomas, are mature lymphatic malformations, consisting of abnormal lymphatic vessels. Surgical excision is considered by most surgeons to be the treatment of choice for lymphangioma. Laser beam has been used to treat superficial or small lymphatic malformations by excision or by photocoagulation, and to excise or photocoagulate small lymphangiomas. Patients and methods: Seventeen patients with diffuse and unexcisable lymphangiomas were treated using a CO2 laser with specific settings: beam was 2W in noncontact and defocus mode, power density was 0.63W/cm2 for irradiation time in the range of 3– 5min, and the estimated energy density range was 114.65–191.02 J/cm2. The beam diameter at the tissular impact point was –2 cm. The laser beam was defocused to provoke a deep heat generation that would dry up the lymphatic tissues and induce deep tissue necrosis that heals by fibrous tissue process. Results: The results were satisfactory and stable, with localized recurrence in three cases. The recurrent areas were re-treated using the same technique successfully and with no further recurrence. Conclusions: The use of CO2 laser under the suggested irradiation conditions can be considered a useful technique for the treatment of invasive lymphangiomas. [less ▲]Detailed reference viewed: 21 (2 ULg) La Cour constitutionnelle et la Princesse au petit pois: note sous Cour constitutionnelle, 3 février 2016Fierens, Jacques ; Mathieu, Géraldinein Actualités du Droit de la Famille (2016), 18/2016Detailed reference viewed: 19 (2 ULg) Brentano, la théorie des catégories et la définition de la substanceBoccaccini, Federico in Etudes Philosophiques (2016)Detailed reference viewed: 28 (0 ULg) Antes del "monstruo" de Rojas: Las conversiones de José Martín RecuerdaFrancois, Jeromine in Dicenda (2016), 35Detailed reference viewed: 24 (0 ULg) COMPUTED TOMOGRAPHY AND MAGNITEC RESONANCE FINDINGS IN ATHLETES AT RISK FOR SUDDEN CARDIAC DEATHGHEKIERE, olivier; Nchimi Longang, Alain ; BIJNENES, Eric et alin Journal of the Belgian Society of Radiology (2016), 44Detailed reference viewed: 19 (2 ULg) Breast cancer in a male to female transsexual patient with a BRCA2 mutationCORMAN, Vinciane ; Potorac, Iulia ; Manto, Florence et alin Endocrine-Related Cancer (2016), 23(5), 391-397Breast cancer is rare in male patients. Certain predisposing factors, be they genetic (e.g., BRCA2 gene mutations) or hormonal (imbalance between estrogen and androgen levels), have been implicated in ... [more ▼]Breast cancer is rare in male patients. Certain predisposing factors, be they genetic (e.g., BRCA2 gene mutations) or hormonal (imbalance between estrogen and androgen levels), have been implicated in male breast cancer pathophysiology. Male-to-female (MtF) transsexualism is a condition that generally involves cross-sex hormone therapy. Anti-androgens and estrogens are used to mimic the female hormonal environment and induce the cross-sex secondary characteristics. In certain situations, the change in the hormonal milieu can be disadvantageous and favor the development of hormonedependent pathologies, such as cancer. We report a case of a MtF transgender patient who developed breast cancer after 7 years of cross-sex hormonal therapy. The patient was found to be BRCA2 positive, and suffered recurrent disease. The patient was unaware of being a member of an established BRCA2 mutation-positive kindred. This represents the first case of a BRCA2 mutation predisposing to breast cancer in a MtF transgender patient. [less ▲]Detailed reference viewed: 48 (18 ULg) Self-continuity across time in schizophrenia: an exploration of phenomenological and narrative continuity in the past and futureAllé, M. C.; D'Argembeau, Arnaud ; Schneider, P. et alin Comprehensive Psychiatry (2016), 69Detailed reference viewed: 23 (5 ULg) Shedding new light on representational neglect: The importance of dissociating visual and spatial componentsWansard, Murielle ; Meulemans, Thierry ; Geurten, Marie in Neuropsychologia (2016), 84Over the last decade, many studies have demonstrated that visuospatial working memory (VSWM) can be divided into two subsystems, dealing respectively with spatial and visual information. A similar ... [more ▼]Over the last decade, many studies have demonstrated that visuospatial working memory (VSWM) can be divided into two subsystems, dealing respectively with spatial and visual information. A similar dissociation has been observed in brain-damaged patients without neglect for mental imagery skills. The first aim of the present study was to examine whether performance dissociations between spatial and visual mental imagery can be observed in unilateral neglect. The second objective was to further investigate the role of spatial and visual working memory subsystems in the mental representation abilities of neglect patients and healthy controls, and their dependence on the nature of the mental imagery tasks performed. The results showed that spatial and visual imagery processes can be selectively impaired in unilateral neglect. Spatial working memory skills were also found to strongly predict spatial imagery score in the two experimental groups. However, contrary to what was observed in healthy controls, visual working memory did not appear to predict performance on visual imagery tasks in neglect patients. Overall, these findings highlight the importance of investigating both visual and spatial components of working memory and mental imagery in neglect patients. [less ▲]Detailed reference viewed: 22 (4 ULg) Growth hormone releasing hormone excess and blockade in X-LAG syndrome.Daly, Adrian Francis ; Lysy, Philippe; Defilles, Celine et alin Endocrine-related cancer (2016)X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and ... [more ▼]X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GH-releasing hormone (GHRH) levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(D-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. [less ▲]Detailed reference viewed: 38 (17 ULg) New Hosts of The Lassa Virus.Olayemi, Ayodeji; Cadar, Daniel; Magassouba, N. Faly et alin Scientific Reports (2016), 6Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to ... [more ▼]Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa. [less ▲]Detailed reference viewed: 5 (1 ULg) In vitro screening of mare's milk antimicrobial effect and antiproliverative activity.Guri, Anilda; Paligot, Michèle; Crevecoeur, Sébastien et alin FEMS Microbiology Letters (2016), 363(2), 1-7The aims of this study were to examine the effect of mare's milk on virulence gene expression of Salmonella Typhimurium and observe its potential activity on proliferation of adenocarcinoma Caco-2 cells ... [more ▼]The aims of this study were to examine the effect of mare's milk on virulence gene expression of Salmonella Typhimurium and observe its potential activity on proliferation of adenocarcinoma Caco-2 cells. Different supernatants of mare's milk, raw or heat-treated at 65°C for 15 s or 30 min, were studied. The changes in hilA gene expression of Salmonella Typhimurium in presence of mare's milk supernatants were assessed using a reporter luminescent strain. A significant decrease in hilA gene expression was observed with all tested supernatants. Virulence gene expression was then assessed using qPCR on a wild-type strain of Salmonella Typhimurium. A significant decrease of hilA and ssrB2 gene expression was observed with raw milk supernatants but not with heat-treated supernatants. The same supernatants were administered to Caco-2 cells to measure their proliferation rate. A significant reduction of proliferative effect was observed only with raw milk supernatants. This study reports that raw mare's milk was able to modulate virulence gene expression of Salmonella Typhimurium and exerts antiproliferative effects on Caco-2 cells. These results may offer new approaches for promoting gastrointestinal health. [less ▲]Detailed reference viewed: 17 (6 ULg) Efficacy and safety of hyaluronic acid in the management of osteoarthritis : Evidence from real-life setting trials and surveys.Maheu, E.; Rannou, F.; Reginster, Jean-Yves in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 28-33The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee ... [more ▼]The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee osteoarthritis (OA) as second-line treatment in patients who remain symptomatic despite use of non-steroidal anti-inflammatory drugs (NSAIDs). This recommendation is based upon accumulating evidence that IA HA provides a significant benefit in knee OA. There is good evidence that IA HA injections reduce pain and increase function in knee OA, and the benefits are long-lasting as compared with IA corticosteroids. Evidence from real-life studies of repeat courses of IA HA demonstrates an improvement in pain or function lasting up to 40 months (12 months after the last injection cycle), a reduction in use of concomitant analgesia by up to 50%, and suggests that there may be a delay in the need for total knee replacement (TKR) of around 2 years. The clinical benefit of IA HA on knee OA may be 2-fold: (i) mechanical viscosupplementation of the joint (allowing lubrication and shock absorption) and (ii) the re-establishment of joint homeostasis through induction of endogenous HA production, which continues long after the exogenous injection has left the joint.The magnitude of the clinical effect may be different for different HA products, but this has not been proven so far and requires further investigation. IA HA injections are generally considered to be safe,although a slightly higher number of cases of local reactions and post-injection non-septic arthritis has been reported with high molecular weight cross-linked HAs. The use of IA HA in knee OA patients with mild–moderate disease, and for more severe patients wishing to delay TKR surgery,is recommended by the ESCEO taskforce. Further investigation into the OA patient types most likely to benefit from IA HA is warranted. Viscosupplementation with IA HA is a safe and effective component of the multi-modal management of knee OA. [less ▲]Detailed reference viewed: 19 (6 ULg) Salicylic acid differently impacts ethylene and polyamine synthesis in the glycophyte Solanum lycopersicum and the wild-related halophyte Solanum chilense exposed to mild salt stresGharbi, Emna; Martinez, Juan Pablo; Benahmed, Hela et alin Physiologia Plantarum (2016), 171This study aimed to determine the effects of exogenous application of salicylic acid on the toxic effects of salt in relation to ethylene and polyamine synthesis, and to correlate these traits with the ... [more ▼]This study aimed to determine the effects of exogenous application of salicylic acid on the toxic effects of salt in relation to ethylene and polyamine synthesis, and to correlate these traits with the expression of genes involved in ethylene and polyamine metabolism in two tomato species differing in their sensitivity to salt stress, Solanum lycopersicum cv Ailsa Craig and its wild salt-resistant relative Solanum chilense. [less ▲]Detailed reference viewed: 29 (6 ULg) Earthquake imprints on a lacustrine deltaic system: the Kürk Delta along the East Anatolian Fault (Turkey)Hubert, Aurelia ; El Ouahabi, Meriam ; Garcia-Moreno, David et alin Sedimentology (2016)Deltas contain sedimentary records that are not only indicative of water level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures ... [more ▼]Deltas contain sedimentary records that are not only indicative of water level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures. The Kürk lacustrine delta lies at the south-western extremity of Lake Hazar in eastern Turkey and is adjacent to the seismogenic East Anatolian Fault (EAF), which has generated earthquakes of magnitude 7. In this paper we have reevaluated water level changes and earthquake shaking that have affected the Kürk Delta combining geophysical data (seismic-reflection profiles and side-scan sonar), remote sensing images, historical data, onland outcrops and offshore coring. The history of water level changes provides a temporal framework for the depositional record. In addition to the commonly soft-sediment-deformation documented previously, onland outcrops reveal a record of deformation (fracturing, tilt and clastic dykes) linked to large earthquake-induced liquefactions and lateral spreading. The recurrent liquefaction structures can be used to obtain a paleoseismological record. Five event horizons were identified that could be linked to historical earthquakes occurring in the last 1000 years along the EAF. Sedimentary cores sampling the most recent subaqueous sedimentation revealed the occurrence of another type of earthquake indicator. Based on radionuclide dating (137Cs and 210Pb), two major sedimentary events were attributed to the 1874-1875 EAF earthquake sequence. Their sedimentological characteristics were determined by X-ray imagery, XRD, LOI, grain-size distribution and geophysical measurements. The events are interpreted to be hyperpycnal deposits linked to post-seismic sediment reworking of earthquake-triggered landslides. [less ▲]Detailed reference viewed: 45 (1 ULg) Assessment of cardiovascular risk of new drugs for the treatment of diabetes mellitus: risk assessment vs. risk aversion.Zannad, Faiez; Stough, Wendy Gattis; Lipicky, Raymond J. et alin European heart journal. Cardiovascular pharmacotherapy (2016), 2(3), 200-205The Food and Drug Administration issued guidance for evaluating the cardiovascular risk of new diabetes mellitus drugs in 2008. Accumulating evidence from several completed trials conducted within this ... [more ▼]The Food and Drug Administration issued guidance for evaluating the cardiovascular risk of new diabetes mellitus drugs in 2008. Accumulating evidence from several completed trials conducted within this framework raises questions as to whether requiring safety outcome studies for all new diabetes mellitus therapies remains justified. Given the burden of cardiovascular disease in patients with diabetes, the focus should shift towards cardiovascular outcome studies designed to evaluate efficacy (i.e. to determine the efficacy of a drug over placebo or standard care) rather than demonstrating that risk is not increased by a pre-specified safety margin. All stakeholders are responsible for ensuring that new drug approvals occur under conditions of appropriate safety and effectiveness. It is also a shared responsibility to avoid unnecessary hurdles that may compromise access to useful drugs and threaten the sustainability of health systems. It is critical to renew this debate so that stakeholders can collectively determine the optimal approach for developing new drugs to treat type 2 diabetes mellitus. [less ▲]Detailed reference viewed: 5 (0 ULg) The Medium is the Message. Olivier Schrauwen's ‘Arsène Schrauwen’ Beyond Expectations of Autobiography, Colonial History and the Graphic NovelCrucifix, Benoît ; Meesters, Gertin European Comic Art (2016), 9(1), 24-62This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the ... [more ▼]This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the field of comics. First of all, Schrauwen playfully questions the entrenchment of autobiography in the contemporary graphic novel by presenting a wholly fantasized adventure as biographical family history. This play with generic expectations is continued through Schrauwen’s reliance on the tropes of the adventure story and its figuration of the voyage. Arsène Schrauwen also draws on stereotypical images of both Belgium and the Belgian Congo and integrates them into a grotesque narrative so as to question the supposed unicity of the individual and colonial bodies. Last but not least, the book displays a highly self-reflexive approach to comics storytelling, building on a legacy from Flemish comics in order to play with reading conventions, graphic enunciation and abstraction, thereby thematising the perception of the main character. [less ▲]Detailed reference viewed: 57 (8 ULg) An Intronic MBTPS2 Variant Results in a Splicing Defect in Horses with Brindle Coat Texture.Murgiano, Leonardo ; Waluk, Dominik P.; Towers, Rachel et alin G3: Genes, Genomes, Genetics (2016), 6(9), 2963-70We investigated a family of horses exhibiting irregular vertical stripes in their hair coat texture along the neck, back, hindquarters, and upper legs. This phenotype is termed "brindle" by horse breeders ... [more ▼]We investigated a family of horses exhibiting irregular vertical stripes in their hair coat texture along the neck, back, hindquarters, and upper legs. This phenotype is termed "brindle" by horse breeders. We propose the term "brindle 1 (BR1)" for this specific form of brindle. In some BR1 horses, the stripes were also differentially pigmented. Pedigree analyses were suggestive of a monogenic X-chromosomal semidominant mode of inheritance. Haplotype analyses identified a 5 Mb candidate region on chromosome X. Whole genome sequencing of four BR1 and 60 nonbrindle horses identified 61 private variants in the critical interval, none of them located in an exon of an annotated gene. However, one of the private variants was close to an exon/intron boundary in intron 10 of the MBTPS2 gene encoding the membrane bound transcription factor peptidase, site 2 (c.1437+4T>C). Different coding variants in this gene lead to three related genodermatoses in human patients. We therefore analyzed MBTPS2 transcripts in skin, and identified an aberrant transcript in a BR1 horse, which lacked the entire exon 10 and parts of exon 11. The MBTPS2:c1437+4T>C variant showed perfect cosegregation with the brindle phenotype in the investigated family, and was absent from 457 control horses of diverse breeds. Altogether, our genetic data, and previous knowledge on MBTPS2 function in the skin, suggest that the identified MBTPS2 intronic variant leads to partial exon skipping, and causes the BR1 phenotype in horses. [less ▲]Detailed reference viewed: 8 (3 ULg) Examen de jurisprudence (2010-2013) - Les sociétés commerciales (première partie)Léonard, Laura ; Caprasse, Olivier; Dieux, Xavier et alin Revue Critique de Jurisprudence Belge [= RCJB] (2016), (1), Detailed reference viewed: 29 (3 ULg) Measurement of emerging dechloranes in human serum using modulated gas chromatography coupled to electron capture negative ionization time-of-flight mass spectrometryBrasseur, C; Pirard, C; L'Homme, B et alin Rapid Communications in Mass Spectrometry (2016), 30 Clinical sentinel surveillance of equine West Nile fever, SpainSaegerman, Claude ; Alba-Casals, A; Garcia-Bocanegra, I et alin Transboundary and Emerging Diseases (2016), 63(2), 184-193Detailed reference viewed: 50 (20 ULg) Compact and Integrated Approach for Advanced End-to-end Production, Purification, and Aqueous Formulation of Lidocaine HydrochlorideMonbaliu, Jean-Christophe ; Stelzer, Torsten; Revalor, Eve et alin Organic Process Research & Development (2016)A compact, fully integrated, and automated system is developed for end-to-end production, purification, and formulation of the active pharmaceutical ingredient (API) lidocaine hydrochloride, a widely used ... [more ▼]A compact, fully integrated, and automated system is developed for end-to-end production, purification, and formulation of the active pharmaceutical ingredient (API) lidocaine hydrochloride, a widely used local anesthetic. The purification strategy includes appropriate combination of extraction, reactive crystallization, and antisolvent cooling crystallization that enables the production of lidocaine hydrochloride formulated solution, for topical application meeting US Pharmacopeia (USP) standards. Based on the optimal yield observed in each step, the system sustains a daily production of 810 doses (dosage strength = 20 mg mL-1 i.e. 2% formulation in commercial denomination). [less ▲]Detailed reference viewed: 16 (3 ULg) Efficiency of Neutralized Antibacterial Culture Supernatant from Bacteriocinogenic Lactic Acid Bacteria Supplemented With Salt in Control of Microorganisms Present in Senegalese Artisanally Handled Fish by Immersion Preservative Technology During Gueldj Seafood Processing at 10°c and 30°cDiop, Michel; Alvarez, Valente; Guiro, Amadou et alin International Journal of Food Microbiology (2016), 1(1), Detailed reference viewed: 13 (1 ULg) Reconstruction of the Schmallenberg virus epidemic in Belgium: Complementary use of disease surveillance approachesPoskin, A; Theron, Léonard ; Hanon, JB et alin Veterinary Microbiology (2016), 183Detailed reference viewed: 28 (4 ULg) Les exercices de contrôle moteur pour le traitement des lombalgies non-spécifiques aiguësDemoulin, Christophe in Cochrane Database of Systematic Reviews (Online) (2016)Traduction en Français du résumé de la revueDetailed reference viewed: 30 (5 ULg) Recurrent pulsations in Saturn’s high latitude magnetosphereMitchell, D.G.; Carbary, J.F.; Bunce, E.J. et alin Icarus (2016)Detailed reference viewed: 15 (3 ULg) [18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinomaWITHOFS, Nadia ; Martinive, Philippe ; VANDERICK, Jean et alin European journal of nuclear medicine and molecular imaging (2016)PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal ... [more ▼]PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use. [less ▲]Detailed reference viewed: 47 (12 ULg) The internal consistency of the North Sea carbonate systemSalt, Lesley A.; Thomas, Helmuth; Bozec, Yann et alin Journal of Marine Systems (2016), 157Abstract In 2002 (February) and 2005 (August), the full suite of carbonate system parameters (total alkalinity (AT), dissolved inorganic carbon (DIC), pH, and partial pressure of \{CO2\} (pCO2) were ... [more ▼]Abstract In 2002 (February) and 2005 (August), the full suite of carbonate system parameters (total alkalinity (AT), dissolved inorganic carbon (DIC), pH, and partial pressure of \{CO2\} (pCO2) were measured on two re-occupations of the entire North Sea basin, with three parameters (AT, DIC, pCO2) measured on four additional re-occupations, covering all four seasons, allowing an assessment of the internal consistency of the carbonate system. For most of the year, there is a similar level of internal consistency, with \{AT\} being calculated to within ± 6 μmol kg− 1 using \{DIC\} and pH, \{DIC\} to ± 6 μmol kg− 1 using \{AT\} and pH, pH to ± 0.008 using \{AT\} and pCO2, and pCO2 to ± 8 μatm using \{DIC\} and pH, with the dissociation constants of Millero et al. (2006). In spring, however, we observe a significant decline in the ability to accurately calculate the carbonate system. Lower consistency is observed with an increasing fraction of Baltic Sea water, caused by the high contribution of organic alkalinity in this water mass, not accounted for in the carbonate system calculations. Attempts to improve the internal consistency by accounting for the unconventional salinity–borate relationships in freshwater and the Baltic Sea, and through application of the new North Atlantic salinity–boron relationship (Lee et al., 2010), resulted in no significant difference in the internal consistency. [less ▲]Detailed reference viewed: 36 (1 ULg) COMPARISON OF ULTRASOUND-GUIDED VS. STANDARD LANDMARK TECHNIQUES FOR TRAINING NOVICE OPERATORS IN PLACING NEEDLES INTO THE LUMBAR SUBARACHNOID SPACE OF CANINE CADAVERSEtienne, Anne-Laure ; Delguste, Catherine ; Busoni, Valeria in Veterinary Radiology & Ultrasound (2016)The standard technique for placing a needle into the canine lumbar subarachnoid space is primarily based on palpation of anatomic landmarks and use of probing movements of the needle, however, this ... [more ▼]The standard technique for placing a needle into the canine lumbar subarachnoid space is primarily based on palpation of anatomic landmarks and use of probing movements of the needle, however, this technique can be challenging for novice operators. The aim of the current observational, prospective, ex vivo, feasibility study was to compare ultrasound-guided vs. standard anatomic landmark approaches for novices performing needle placement into the lumbar subarachnoid space using dog cadavers. Eight experienced operators validated the canine cadaver model as usable for training landmark and ultrasound-guided needle placement into the lumbar subarachnoid space based on realistic anatomy and tissue consistency. With informed consent, 67 final year veterinary students were prospectively enrolled in the study. Students had no prior experience in needle placement into the lumbar subarachnoid space or use of ultrasound. Each student received a short theoretical training about each technique before the trial and then attempted blind landmark-guided and ultrasound-guided techniques on randomized canine cadavers. After having performed both procedures, the operators completed a self-evaluation questionnaire about their performance and self-confidence. Total success rates for students were 48% and 77% for the landmark- and ultrasound-guided techniques, respectively. Ultrasound guidance significantly increased total success rate when compared to the landmark-guided technique and significantly reduced the number of attempts. With ultrasound guidance self-confidence was improved, without bringing any significant change in duration of the needle placement procedure. Findings indicated that use of ultrasound guidance and cadavers are feasible methods for training novice operators in needle placement into the canine lumbar subarachnoid space. [less ▲]Detailed reference viewed: 22 (4 ULg) Entre valorisation, conservation et dépérissement: la gestion de nos chênaies à la croisée des cheminsDelahaye, Laurence; Claessens, Hugues ; Losseau, Julie et alin FORÊT.NATURE (2016), 140(Juillet-Août-Septembre), 59-68Une crise sanitaire touche les peuplements de chêne, essentiellement ardennais. Des phénomènes de dépérissement sont observés de plus en plus souvent depuis 2010 pour atteindre aujourd'hui des proportions ... [more ▼]Une crise sanitaire touche les peuplements de chêne, essentiellement ardennais. Des phénomènes de dépérissement sont observés de plus en plus souvent depuis 2010 pour atteindre aujourd'hui des proportions inquiétantes. En Ardenne, en 2014, près de 40% des chênes pédonculés étaient affectés par le dépérissement. Les dépérissements sont provoqués par un ensemble de stress biotiques ou abiotiques, simultanés ou séquentiels. La sylviculture joue probablement également un rôle (inadéquation avec la station, surface terrière trop élevée ...). Mais même s'il y a crise, il n'y a pas urgence. Aucune dégradation significative du bois n'est observée au cours du dépérissement ni même jusqu'à 3 ou 4 ans après la mort de l'arbre. L'exploitation rapide et désordonnée des arbres morts n'est pas indispensable, d'autant qu'elle pourrait provoquer plus de dégâts que le dépérissement lui-même. Les interventions se feront en fonction des enjeux et des objectifs du plan d'aménagement, et selon le taux d'arbres touchés. Le dépérissement des chênes touche largement des arbres qui n'étaient pas en station. Toute information est à relayer auprès de l'OWSF ou de ses partenaires scientifiques afin d'avancer vers la compréhension du phénomène et la meilleure manière de le gérer. [less ▲]Detailed reference viewed: 22 (2 ULg) There is nothing more pratical than a good theory. Conceptuals tools for the Practioners in ConservationVerbeeck, Muriel in Studies in Conservation (2016)This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed ... [more ▼]This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed from Gerard Genette are used to analyze a practical case: Dirty Corner, installation by Anish Kapoor vandalized in the gardens of Versailles. [less ▲]Detailed reference viewed: 43 (4 ULg) Postmodernité et psychothérapie : Quelques croisements entre les travaux de Sami-Ali et ceux de Deleuze et FoucaultEnglebert, Jérôme in Psychosomatique Relationnelle (2016), 6Detailed reference viewed: 48 (10 ULg) Non-monotonous anisotropy in charge conduction induced by antiferrodistortive transition in metallic SrTiO3Tao, Qian; Loret, Bastien; Xu, Bin et alin Physical Review B (2016), 94Detailed reference viewed: 68 (7 ULg) Can orbital angle morphology distinguish dogs from wolves?Janssens, Luc; Spanoghe, Inge; Miller, Rebecca et alin Zoomorphology (2016)Detailed reference viewed: 9 (0 ULg) The clinical challenge of concomitant aortic and mitral valve stenosis.Unger, Philippe; Lancellotti, Patrizio ; de Canniere, Didierin Acta Cardiologica (2016), 71(1), 3-6The coexistence of mitral and aortic stenosis is not exceptional. Whereas rheumatic fever is currently plummeting in the Western countries, the incidence of degenerative disease is inversely increasing ... [more ▼]The coexistence of mitral and aortic stenosis is not exceptional. Whereas rheumatic fever is currently plummeting in the Western countries, the incidence of degenerative disease is inversely increasing. The haemodynamic interactions which may interfere both with the usual echocardiographic parameters and with the invasive assessment may render the diagnosis difficult. The therapeutic challenges raised by this entity should not be underestimated. The increased morbidity and mortality of multivalvular surgery has to be balanced with the risk of a second operation down the line if one valvular involvement, deemed of a lesser importance, is neglected. This complex situation requires the multidisciplinary approach of a heart team involving surgeons, cardiologists, geriatrists if need be and imaging specialists. [less ▲]Detailed reference viewed: 10 (0 ULg) Hydrogeochemical processes constrained by multivariate statistical methods and isotopic evidence of groundwater recharge in the aquifer of Figuig, eastern High Atlas of moroccoJilali, A.; Fagel, Nathalie ; Amar, M. et alin Arabian Journal of Geosciences (2016)Detailed reference viewed: 103 (19 ULg) Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.Kumar, Amit; Abbas, Wasim; Colin, Laurence et alin Scientific reports (2016), 6Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In ... [more ▼]Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In primary T cells treated with exogenous Nef or acutely infected with Nef-expressing HIV-1 in vitro, Akt became phosphorylated on serine(473) and threonine(308). In vitro, Akt activation mediated by Nef in T-cells was blocked by HIV protease inhibitors (PI), but not by reverse transcriptase inhibitors (RTI). Ex vivo, we found that the Akt pathway is hyperactivated in peripheral blood lymphocytes (PBLs) from cART naive HIV-1-infected patients. PBLs isolated from PI-treated patients, but not from RTI-treated patients, exhibited decreased Akt activation, T-cell proliferation and IL-2 production. We found that PI but not RTI can block HIV-1 reactivation in latently infected J-Lat lymphoid cells stimulated with various stimuli. Using luciferase measurement, we further confirmed that Nef-mediated reactivation of HIV-1 from latency in 1G5 cells was blocked by PI parallel to decreased Akt activation. Our results indicate that PI-mediated blockade of Akt activation could impact the HIV-1 reservoir and support the need to further assess the therapeutic use of HIV-1 PI in order to curtail latently infected cells in HIV-1-infected patients. [less ▲]Detailed reference viewed: 19 (1 ULg) Early BMP, Wnt and Ca(2+)/PKC pathway activation predicts the bone forming capacity of periosteal cells in combination with calcium phosphates.Bolander, Johanna; Chai, Yoke Chin; Geris, Liesbet et alin Biomaterials (2016), 86The development of osteoinductive calcium phosphate- (CaP) based biomaterials has, and continues to be, a major focus in the field of bone tissue engineering. However, limited insight into the ... [more ▼]The development of osteoinductive calcium phosphate- (CaP) based biomaterials has, and continues to be, a major focus in the field of bone tissue engineering. However, limited insight into the spatiotemporal activation of signalling pathways has hampered the optimisation of in vivo bone formation and subsequent clinical translation. To gain further knowledge regarding the early molecular events governing bone tissue formation, we combined human periosteum derived progenitor cells with three types of clinically used CaP-scaffolds, to obtain constructs with a distinct range of bone forming capacity in vivo. Protein phosphorylation together with gene expression for key ligands and target genes were investigated 24 hours after cell seeding in vitro, and 3 and 12 days post ectopic implantation in nude mice. A computational modelling approach was used to deduce critical factors for bone formation 8 weeks post implantation. The combined Ca(2+)-mediated activation of BMP-, Wnt- and PKC signalling pathways 3 days post implantation were able to discriminate the bone forming from the non-bone forming constructs. Subsequently, a mathematical model able to predict in vivo bone formation with 96% accuracy was developed. This study illustrates the importance of defining and understanding CaP-activated signalling pathways that are required and sufficient for in vivo bone formation. Furthermore, we demonstrate the reliability of mathematical modelling as a tool to analyse and deduce key factors within an empirical data set and highlight its relevance to the translation of regenerative medicine strategies. [less ▲]Detailed reference viewed: 19 (0 ULg) De la matérialisation de quelques concepts phénoménologiques.Frère, Bruno in SociologieS (2016)Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été ... [more ▼]Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été d’usage mais s’avère aujourd’hui urgent. En effet, faisant l’économie d’une considération sérieuse de la prise que lui offre la sociologie sur le monde, la philosophie risque d’échouer à penser les transformations politiques et économiques des société contemporaines. A l’inverse, une certaine tendance positiviste semble menacer la sociologie qui se débarrasserait de toutes connaissances philosophiques. Afin de rappeler l’intérêt que l’une et l’autre se doivent réciproquement, cet article voudrait montrer comment il peut être utile à la sociologie de donner corps à certains concepts philosophiques lorsqu’elle s’avère confrontée à certaines difficultés. Afin d’illustrer le propos, nous nous référerons à un exemple puisé au sein de l’économie solidaire. Ici en effet, c’est en acceptant que se matérialise dans l’enquête le concept d’état d’esprit intentionnel que la philosophie phénoménologique vient à point nommé pour aider la sociologie pragmatique de la critique à se représenter les contradictions qui peuvent apparaître entre action et justification. Et ce sans pour autant renoncer à « prendre les gens aux sérieux » et s’en retourner vers une traditionnelle sociologie du dévoilement qui expliquerait ces contradictions par le décalage qui existerait entre habitus (ou sens pratique) d’une part et illusions réflexives des acteurs d’autre part. Mots clefs : phénoménologie, états d’esprit intentionnel, philosophie, sociologie pragmatique, économie solidaire. Summary : This article is a reflexion about the relationship between sociology and philosophy. It will show that building bridges between the two disciplines, whilst recurrent, is more urgent now than ever. On the one hand, philosophy will be unable to contribute meaningfully to discussions about the major political and economic transformations experienced by contemporary societies without engaging with Sociology. On the other hand without philosophical insights Sociology risks drifting towards positivistic trends. In this article we propose to show how each discipline can benefit from cross-fertilisations and in particular how Sociology can appropriate philosophical concepts to address certain challenges. Drawing on a specific example from solidary economy, we will show that the concept of intentional mindset borrowed from phenomenological philosophy enables pragmatic sociology to account for the gaps which are liable to emerge between action and justification. This concept fulfills the key tenet of pragmatic sociology that to take social actors seriously we must eschew a type of sociological approach which would consist of revealing that the gaps between action and justification arise from social actors’ illusory apprehension of their habitus. Key words: phénoménology, mindset, states of mind, philosophy, pragmatic sociology, solidarity economy. [less ▲]Detailed reference viewed: 33 (0 ULg) Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells.Bourcy, Morgane ; Suarez-Carmona, Meggy ; Lambert, Justine et alin Cancer Research (2016)Epithelial-mesenchymal transition (EMT) is prominent in circulating tumor cells (CTC), but how it influences metastatic spread in this setting is obscure. Insofar as blood provides a specific ... [more ▼]Epithelial-mesenchymal transition (EMT) is prominent in circulating tumor cells (CTC), but how it influences metastatic spread in this setting is obscure. Insofar as blood provides a specific microenvironment for tumor cells, we explored a potential link between EMT and coagulation that may provide EMT-positive CTC with enhanced colonizing properties. Here we report that EMT induces tissue factor (TF), a major cell-associated initiator of coagulation and related pro-coagulant properties in the blood. TF blockade by antibody or shRNA diminished the pro-coagulant activity of EMT-positive cells, confirming a functional role for TF in these processes. Silencing the EMT transcription factor ZEB1 inhibited both EMT-associated TF expression and coagulant activity, further strengthening the link between EMT and coagulation. Accordingly, EMT-positive cells exhibited a higher persistance/survival in the lungs of mice colonized after intravenous injection, a feature diminished by TF or ZEB1 silencing. In tumor cells with limited metastatic capability, enforcing expression of the EMT transcription factor Snail increased TF, coagulant properties and early metastasis. Clinically, we identified a subpopulation of CTC expressing vimentin and TF in the blood of metastatic breast cancer patients consistent with our observations. Overall, our findings define a novel EMT-TF regulatory axis which triggers local activation of coagulation pathways to support metastatic colonization of EMT-positive CTC. [less ▲]Detailed reference viewed: 54 (22 ULg) Surface Constrained Elastic Rods with Application to the SphereHuynen, Alexandre ; Detournay, Emmanuel; Denoël, Vincent in Journal of Elasticity (2016)The unilateral contact between an elastic rod and a rigid surface is encountered in numerous biological and engineering applications. Along continuous contacts, the centerline of the rod reflects the ... [more ▼]The unilateral contact between an elastic rod and a rigid surface is encountered in numerous biological and engineering applications. Along continuous contacts, the centerline of the rod reflects the geometry of the constraining surface. This restriction of the rod axis to surface bound configurations enters its local equilibrium through a reaction pressure which ensures the compatibility between the deformation and the restraint geometry. The classic equations governing the static equilibrium of elastic rods are particularized to surface bound configurations by (i) specifying the location of the rod axis in terms of its coordinates in the parameter space associated with the constraining surface parameterization, and (ii) characterizing the orientation of its material frame through its rotation with respect to the surface normal. This formulation, which emphasizes the relations between the rod configuration and the geometry of the constraint, also leads to an expression for the reaction pressure. This approach is then validated on a spherical surface by comparing with known solutions for elastic curves, i.e., inextensible and twist free rods. [less ▲]Detailed reference viewed: 51 (10 ULg) Impact of value chain governance on the development of small scale shrimp farmers in VietnamHo Thi Minh, Hop; Burny, Philippe in International Journal of Business and Economic Sciences Applied Research (2016), 9(2), 93-98Purpose of this paper is to identify the tendency of shrimp value chain development and impact of its governance on the small scale shrimp farmers in Vietnam. Design/methodology/approach - Data from the ... [more ▼]Purpose of this paper is to identify the tendency of shrimp value chain development and impact of its governance on the small scale shrimp farmers in Vietnam. Design/methodology/approach - Data from the shrimp farmers surveys in Mekong delta, Vietnam from 2008-2010 with the update information in 2014 were taken to analyse by the value chain analysis method. Findings – Traditional governance type of the shrimp value chain in the early state (before 2004) showed the different levels of coordination of farmers with collectors, among collectors, and collectors with processing plants. In this type of governance, trust and linkages are inextricably linked. However, they are not strong. The processing plants determine shrimp prices and quality requirement in the market while many collectors do not seem to be highly responsible for the quality of their products. To avoid this limitation, with the governmental support policy to improve farmers’ income, the processing plants set up a direct buying from farmers under contracts. These contracts led to a new governance type with an expectation of improving farmers’ position. However, this model was broken due to several reasons including un-controlled shrimp raw material from small scale and individual farmers. Consequently, processors now tend to establish their own raw material zone to comply shrimp quality assurance, and eject the existence of farmers. This will lead small scale farmers to very difficult problems in finding the market. Poverty and social problems of small scale farmers might appear. The result recommends a greater strengthening and tightening of the value chain. Re-organizing shrimp farmers into legal teams or groups that help farmers to re-participate in the game with others actor in the chain is crucial. Research limitations/implications - The research mainly follows inductive approach in which qualitative methods are dominant due to the difficulties of data collection for the quantitative analysis. [less ▲]Detailed reference viewed: 14 (2 ULg) The role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study.Runhaar, J.; DEROISY, Rita ; van Middelkoop, M. et alin Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 42-48Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a ... [more ▼]Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a tailored diet and exercise program (DEP)or by oral glucosamine sulfate in women at risk for the disease, using a composite clinical and/or radiological outcome. The aim of this updated post-hoc analysis was to re-assess the results according to more precise techniques and take advantage of the 2 x 2 factorial design. Methods: A total of 407 overweight( BMI > or egal 27kg/m2) women of 50–60 years of age with no diagnosis of knee OA were randomized to: (1) noDEP + placebo(Control, N = 102), (2) DEP + placebo (DEP, N = 101), (3) glucosamine sulfate + no DEP (GS, N = 102), and (4) DEP + glucosamine sulfate (DEP + GS, N = 102) and followed for 2.5 years, with standardized postero-anterior, semiflexed (MTP) view knee radiographs at baseline and end of the study. DEP consisted of a tailored low fat and/or low caloric diet and easy to implement physical activities. Glucosamine was given as oral crystalline glucosamine sulfate 1500 mg once daily ,double-blinded vs. placebo. Incident knee OA was defined as radiographic progression of >1mm minimum joint space narrowing (mJSN)in the medial tibiofemoral compartment, as previously assessed by the visual (manual) technique and by a new semi-automated method. Logistic regression analysis was used t ocalculate the odds ratio for the effect of the interventions. Results: After 2.5 years, 11.8% of control subjects developed knee OA. This incidence was decreased with glucosamine sulfate, either alone or in combination with the DEP, but not by the DEP alone. Since there was no statistical interaction between treatments, the 2x2 factorial design allowed analysis of patients receiving glucosamine sulfate (N = 204) vs. those not receiving it (N= 203), similarly for those on the DEP (N = 203) or not (N = 204). Glucosamine sulfate significantly decreased the risk of developing knee OA: odds ratio (OR) = 0.41(95% CI: 0.20–0.85, P = 0.02) by the manual JSN assessment method and OR = 0.42 (95% CI:0.20–0.92, P =0.03) by the semi-automated technique. Conversely, there was no decrease in risk with the DEP. Conclusions: Glucosamine sulfate decreased the risk of developing radiographic knee OA over 2.5 years in overweight, middle-aged women at risk, as determined by medial mJSN progression. Conversely a tailored diet and exercise program exerted no preventive effect, possibly because of the lower than expected effect on weigh tloss. [less ▲]Detailed reference viewed: 45 (9 ULg) Sedimentary impacts of recent moderate earthquakes from the shelves to the basin floor in the western Gulf of CorinthBeckers, Arnaud; Beck, Christian; Hubert, Aurelia et alin Marine Geology (2016)In seismically active areas, long term records of large earthquakes are indispensable to constrain reccurence patterns of large earthquakes. In the western Corinth Rift, one of the most active areas in ... [more ▼]In seismically active areas, long term records of large earthquakes are indispensable to constrain reccurence patterns of large earthquakes. In the western Corinth Rift, one of the most active areas in Europe in terms of seismicity, data about ancient earthquakes are still insufficient, despite historical records covering the last two millenia and several studies in onshore paleoseimology. In this paper, we test the use of offshore sediments from the Gulf of Corinth to identify sediment failures and tsunamis that have been triggered by historical earthquakes. Two shelves (40-100 m deep), one sub-basin (180 m) and the basin floor (330 m) have been sampled by short gravity cores. The cores were analysed in order to identify and characterize event deposits. The age control has been provided by 137Cs and 210Pb activity measurements showing that the cores represent 2 to 4 centuries of sedimentation. In each site, sandy event deposits are interbeded in the muddy, hemipelagic sedimentation. The age of event deposits has been compared to the record of historical earthquakes using new and published macroseismic data. This comparison shows temporal coincidence of some event deposits and documented earthquakes with a macroseismic intensity ≥ VII in the area, e.g. in A.D. 1861, 1888 and 1909. In near-shore, shallow water settings, the record of event deposits does not exactly fit with the historical record of large earthquakes because too few event deposits are present. This may be due to the absence of sediment failures or to a lower preservation of the deposits in such settings. In the deepest site, in the basin floor, the correspondence is better: a sandy turbidite probably corresponds to each large earthquake since A.D. 1850, except one aseismic sediment density flow that occurred at the end of the 20th century. Surprisingly, the Ms=6.2, June 15, 1995 Aigion earthquake is only possibly recorded in one near-shore site on the Aigion Shelf, in the form of a tsunami back-wash flow deposit. This study showed that moderate earthquakes (M 5.8-6.5) can significantly impact marine sediments. Regarding the evaluation of seismic hazard in the area, the basin floor is proposed as a promising site for long term paleoseismology in the Gulf of Corinth, while shallower settings need to be considered more carefully [less ▲]Detailed reference viewed: 40 (1 ULg) Physico-chemical properties and amino acid profiles of sap from Tunisian date palmMakhouf-Gafsi, Ines; Mokni-Ghribi, Abir; Brahim, Bchir et alin Scientia Agricola (2016), 73(1), 85-90Date palm sap (Phoenix dactylifera L.), also known as "legmi", is a fresh juice ex¬tracted from date palm trees. The present study aimed to elucidate the effects of collection time (at the beginning of ... [more ▼]Date palm sap (Phoenix dactylifera L.), also known as "legmi", is a fresh juice ex¬tracted from date palm trees. The present study aimed to elucidate the effects of collection time (at the beginning of the tapping period and after seven days of collection) on the amino acid profile and physico-chemical properties of date palm sap from both male and female trees. Dry matter, protein, amino acid, and sugar profiles were determined using the Kjeldahl method, High-Performance Liquid Chromatography (HPLC), and High-Performance Anion-Exchange Chro¬matography with Pulsed Amperometric Detection (HPAEC-PAD), respectively. Date palm sap from both male and female trees contained high levels of carbohydrates. HPLC analysis showed that this fraction was dominated by sucrose in the sap sample from female trees compared to that from male trees. Male date palm sap was noted to exhibit lower dry matter content than female date palm sap but higher protein, total polyphenol, ash, and amino acid contents. While the major essential amino acids in the sap from male trees consisted of valine and threonine, they were represented by lysine and phenylalanine in sap samples from female trees. Further, Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) analysis showed the presence of a proteinic band of 30 kDa only for the sap from male trees. Taken together, the sap from both male and female date palm trees had a number of properties that are highly valued by the functional food industry. [less ▲]Detailed reference viewed: 35 (2 ULg)