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See detailÉtude sur les caractéristiques psychologiques des hommes auteurs de violences conjugales : quel type de fragilité psychique le passage à l’acte violent dissimule-t-il ?
Di Piazza, Laetitia ULg; Blavier, Adelaïde ULg; Kowal, Cécile et al

in Annales Médico-Psychologiques (2017)

Introduction Historically, intimate partner violence has been ignored and minimized, despite its seriousness and widespread prevalence in our culture. In the past three decades, many studies have ... [more ▼]

Introduction Historically, intimate partner violence has been ignored and minimized, despite its seriousness and widespread prevalence in our culture. In the past three decades, many studies have addressed the question of the impact of intimate partner violence on physical or mental health for victims (spouses, ex-partners and children). But, what about authors? Currently, due to the multifactorial character of the phenomenon of domestic violence, it is still difficult to estimate the impact of the existing therapeutic programs which offer a support for the authors of this violence. The current study sought to examine the association between trait impulsivity, alexithymia and depression and the perpetration of physical and psychological intimate partner violence. We focused on particular psychological characteristics that would seem to have much potential as an aid to understand this phenomenon and its prevention and/or treatment. Patients and methods Fifty-three male offenders were surveyed using self-report questionnaires to assess emotional distress (BDI), impulsive behavior (BIS-11) and alexithymia (TAS-20), the inability to experience and express subjective emotions, prior to therapeutic program participation. Results Findings indicated that both alexithymia and depression were significantly associated with violence perpetration. Analyses showed that male intimate partner violence offender reported more depressive feelings and more difficulties to express his emotions than did general population. Furthermore, there are positive and significant correlations between alexithymia, impulsivity and depression. Therefore, if male offenders have difficulties to describe and identify their emotions, they will tend to have more depressive symptoms and also more impulsive behavior. However, we do not observe a difference between men who consult voluntarily therapeutic programs and those who have been forced by legal measure of constraint. Conclusions The present findings continue to suggest a strong link between alexithymia and domestic violence as showed by others studies. Additional researches are clearly needed and may lead not only to a better understanding of aggression but also to the development of better therapeutic interventions. [less ▲]

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See detailHow can seed removal rates of zoochoric tree species be assessed quickly and accurately?
Hambuckers, julien ULg; Dauvrin, Alice; Trolliet, Franck ULg et al

in Forest Ecology and Management (2017), 403

The quantification of seed dispersal and predation processes has been gaining increased importance in the assessment of forest responses to anthropogenic disturbance, but also in developing an ... [more ▼]

The quantification of seed dispersal and predation processes has been gaining increased importance in the assessment of forest responses to anthropogenic disturbance, but also in developing an understanding of forest dynamics facing particular reproductive strategies. Seed removal rate is a reliable estimator of animal activities relating to these processes and can be quickly and easily estimated using a rapid assessment method (RAM) described by Lermyte & Forget (2009) and Boissier et al. (2014). This method consists in selecting trees reaching a given fruit crop in plots of interest and estimating, under each tree, the proportion of removed seeds in a single quadrat among the places having the highest crops; the proportion of removed seeds is obtained by enumeration of fruit scraps and intact fruits and estimation of their seed contents. The objective of this work is to evaluate the reliability of this method and to propose alternative estimation protocols (APs) in order to obtain an index of animal interaction with seeds. To do so, we estimated produced and removed seed numbers in up to 30 random 1 sq.m. quadrats under a total of 19 trees of Afzelia bipindensis, Dialium pachyphyllum/zenkeri and Xylopia staudtii. Secondly, we investigated the influence of tree size and fruit production on seed removal rate using a generalized linear mixed model. Thirdly, we used a generalized linear mixed model and a bootstrap procedure to test if RAM and APs are biased. Then, we compared their accuracy throughout their mean squared error, also obtained with a bootstrap approach. Despite its interesting accuracy, we showed that the RAM is positively biased. Removal rate was obviously influenced by canopy size and fruit production whereas the quadrats with higher fruit production have higher seed removal rates. Thus, trees with representative sizes and crops of the studied plots have to be sampled. Secondly, as an AP, random selection of several quadrats was found to be the best method. Based on these results, we recommend using the mean of three random quadrats per tree to estimate seed removal rate. It is an unbiased estimator, more accurate and more time efficient than the RAM. However, attention should be paid to select a proper quadrat size, in line with seed and fruit numbers, since the accuracy of the methods depends on these quantities. Such a choice could be made using a mean squared error criterion obtained from a preliminary intensive sampling of some specimens of the focal species. [less ▲]

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See detailEffects of a giant exercising board game intervention on ambulatory physical activity among nursing home residents: a preliminary study
Mouton, Alexandre ULg; Gillet, Nicolas; Mouton, Flore et al

in Clinical Interventions in Aging (2017), 12

Purpose: This study examined the effects of a giant (4×3 m) exercising board game intervention on ambulatory physical activity (PA) and a broader array of physical and psychological outcomes among nursing ... [more ▼]

Purpose: This study examined the effects of a giant (4×3 m) exercising board game intervention on ambulatory physical activity (PA) and a broader array of physical and psychological outcomes among nursing home residents. Materials and methods: A quasi-experimental longitudinal study was carried out in two comparable nursing homes. Ten participants (aged 82.5±6.3 and comprising 6 women) meeting the inclusion criteria took part in the 1-month intervention in one nursing home, whereas 11 participants (aged 89.9±3.1 with 8 women) were assigned to the control group in the other nursing home. The giant exercising board game required participants to perform strength, flexibility, balance and endurance activities. The assistance provided by an exercising specialist decreased gradually during the intervention in an autonomy-oriented approach based on the self-determination theory. The following were assessed at baseline, after the intervention and after a follow-up period of 3 months: PA (steps/day and energy expenditure/day with ActiGraph), cognitive status (mini mental state examination), quality of life (EuroQol 5-dimensions), motivation for PA (Behavioral Regulation in Exercise Questionnaire-2), gait and balance (Tinetti and Short Physical Performance Battery), functional mobility (timed up and go), and the muscular isometric strength of the lower limb muscles. Results and conclusion: In the intervention group, PA increased from 2,921 steps/day at baseline to 3,358 steps/day after the intervention (+14.9%, P=0.04) and 4,083 steps/day (+39.8%, P=0.03) after 3 months. Energy expenditure/day also increased after the intervention (+110 kcal/day, +6.3%, P=0.01) and after 3 months (+219 kcal/day, +12.3%, P=0.02). Quality of life (P,0.05), balance and gait (P,0.05), and strength of the ankle (P,0.05) were also improved after 3 months. Such improvements were not observed in the control group. The preliminary results are promising but further investigation is required to confirm and evaluate the long-term effectiveness of PA interventions in nursing homes. [less ▲]

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See detailDeforestation drives functional diversity and fruit quality changes in a tropical tree assemblage
Pessoa, Michaele S.; Hambuckers, Alain ULg; Benchimol, Maíra et al

in Perspectives in Plant Ecology, Evolution & Systematics (2017), 28(C), 78-86

Functional traits associated with plant-animal interactions are essential for forest functionality, given that a higher diversity of fruit traits is likely to maintain a more diverse assemblage of ... [more ▼]

Functional traits associated with plant-animal interactions are essential for forest functionality, given that a higher diversity of fruit traits is likely to maintain a more diverse assemblage of frugivores and consequently promote the seed dispersal function. Yet, shade-intolerant species tend to persist in human-modified landscapes in the long term, which in turn is expect to reduce fruit trait diversity. Here we evaluate how forest cover at the landscape-scale influences the functional diversity of fruit traits, considering the zoochoric tree community and two regeneration strategies separately (shade-tolerant and shade-intolerant species). We sampled 20 forest remnants in the Brazilian Atlantic Forest, located in landscapes with forest cover ranging from 2 to 93%. In each remnant, we established five plots of 25 ×4 m and marked all trees≥5 cm diameter at breast height (DBH). We compared morphological and chemical attributes of fleshy fruits directly related to the attraction of frugivores, and evaluated the similarity of the zoochoric tree assemblage composition along the forest cover gradient, taking into account the two regeneration strategies. We calculated four functional indices (richness, evenness, divergence, and community-level weighted means of trait values) and used either linear models or spatial mixed linear models to evaluate the effects of forest cover on functional diversity. Our main results revealed that forest cover loss has negatively affected fruit functional diversity for the overall zoochoric community. Forest cover loss also affected functional richness and functional evenness for total and shade-tolerant species, and was positively correlated with the content of protein and lipid in fruits of shade-intolerant species. Additionally, sites exhibiting a lower amount of forest cover showed greater compositional similarity among shade-intolerant species but reduced similarity among shade-tolerant species. We conclude that patterns of species reassembly triggered by landscape-scale deforestation decreases the capacity of the remaining forest for provisioning food resources for frugivore assemblages. The maintenance of shade-tolerant species is pivotal in deforested areas, since their fruit quality is not offset by shade-intolerant species. This is particularly important, mainly because shade-intolerant species are those still persisting in disturbed forests; however, their presence will not provide the same food quality supplied by those species lost. [less ▲]

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See detailIn Memoriam Léon Lacroix (1909-2016)
Rochette, Bruno ULg

in Antiquité Classique (2017), 86

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See detailReconsidering Prenatal Hormonal Influences on Human Sexual Orientation: Lessons from Animal Research.
Baum, Michael J.; Bakker, Julie ULg

in Archives of Sexual Behavior (2017)

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See detailAllogeneic stem cell transplantation for patients with myelodysplastic syndrome 70 years of age or older: A retrospective study of the MDS subcommittee of the Chronic Malignancies Working Party (CMWP) of the EBMT
Heidenreich, S; Ziagkos, D; De Wreede, L et al

in Biology of Blood & Marrow Transplantation (2017), 23

In this retrospective analysis we evaluated the outcome of 313 patients aged ≥ 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n ... [more ▼]

In this retrospective analysis we evaluated the outcome of 313 patients aged ≥ 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n = 221) and secondary acute myeloid leukemia (n = 92) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from related (n = 79) or unrelated (n = 234) donors. Median age at HSCT was 72 years (range, 70 to 78). Conditioning regimen was nonmyeloablative (n = 54), reduced intensity (n = 207), or standard intensity (n = 52). Allogeneic HSCT for MDS patients ≥ 70 years was increasingly performed over time. Although during 2000 to 2004 only 16 patients received HSCT, during 2011 to 2013 the number of transplantations increased to 181. The cumulative incidence of nonrelapse mortality at 1 year and relapse at 3 years was 32% and 28%, respectively, with a 3-year overall survival rate of 34%. Good performance, determined by Karnofsky performance status, and recipients’ seronegativity for cytomegalovirus was associated with 3-year estimated overall survival rates of 43% (P = .01) and 46% (P = .002), respectively. Conditioning intensity did not impact survival. After careful patient selection, allogeneic HSCT can be offered to patients older than 70 years with MDS. [less ▲]

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See detailWhole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group.
Hillengass, J.; Moulopoulos, L. A.; Delorme, S. et al

in Blood cancer journal (2017), 7(8), 599

For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the ... [more ▼]

For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either computed tomography (CT) alone or as part of a positron emission tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM. [less ▲]

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See detailRelations on words
Rigo, Michel ULg

in Indagationes Mathematicae (2017), 28

In the first part of this survey, we present classical notions arising in combinatorics on words: growth function of a language, complexity function of an infinite word, pattern avoidance, periodicity and ... [more ▼]

In the first part of this survey, we present classical notions arising in combinatorics on words: growth function of a language, complexity function of an infinite word, pattern avoidance, periodicity and uniform recurrence. Our presentation tries to set up a unified framework with respect to a given binary relation. In the second part, we mainly focus on abelian equivalence, $k$-abelian equivalence, combinatorial coefficients and associated relations, Parikh matrices and $M$-equivalence. In particular, some new refinements of abelian equivalence are introduced. [less ▲]

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See detailMind the (treatment) gap: a global perspective on current and future strategies for prevention of fragility fractures.
Harvey, N.C.W.; McCloskey, E.V.; Mitchell, P.J. et al

in Osteoporosis International (2017), 28

This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall ... [more ▼]

This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall into four distinct themes: (1) case finding and management of individuals at high risk of fracture, (2) public awareness of osteoporosis and fragility fractures, (3) reimbursement and health system policy and (4) epidemiology of fracture in the developing world. Findings from cohort studies, randomised controlled trials, systematic reviews and meta-analyses, in addition to current clinical guidelines, position papers and national and international audits, are summarised, with the intention of providing a prioritised approach to delivery of optimal bone health for all. Systematic approaches to case-finding individuals who are at high risk of sustaining fragility fractures are described. These include strategies and models of care intended to improve case finding for individuals who have sustained fragility fractures, those undergoing treatment with medicines which have an adverse effect on bone health and people who have diseases, whereby bone loss and, consequently, fragility fractures are a common comorbidity. Approaches to deliver primary fracture prevention in a clinically effective and costeffective manner are also explored. Public awareness of osteoporosis is low worldwide. If older people are to be more proactive in the management of their bone health, that needs to change. Effective disease awareness campaigns have been implemented in some countries but need to be undertaken in many more. A major need exists to improve awareness of the risk that osteoporosis poses to individuals who have initiated treatment, with the intention of improving adherence in the long term. A multisector effort is also required to support patients and their clinicians to have meaningful discussions concerning the risk-benefit ratio of osteoporosis treatment. With regard to prioritisation of fragility fracture prevention in national policy, there is much to be done. In the developing world, robust epidemiological estimates of fracture incidence are required to inform policy development. As the aging of the baby boomer generation is upon us, this review provides a comprehensive analysis of how bone health can be improved worldwide for all. [less ▲]

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See detailFirst report of the bee louse Braula schmitzi (Diptera: Braulidae) in apiaries of the “Los Chillos” Valley, Province of Pichincha, Ecuador
Zapata-Carvajal, N; Cherrez-Neacato, A; Martin-Solano, S et al

in Journal of Apicultural Research (2017)

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See detailExploring sex differences in the adult zebra finch brain: in vivo diffusion tensor imaging and ex vivo super-resolution track density imaging
Hamaide, J.; De Groof, G.; Van Steenkiste, G. et al

in NeuroImage (2017), 146

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural ... [more ▼]

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural investigation of the zebra finch brain has been performed ex vivo using invasive methods such as histology. These methods are highly specific, however, they strongly interfere with performing whole-brain analyses and exclude longitudinal studies aimed at establishing causal correlations between neuroplastic events and specific behavioral performances. Therefore, the aim of the current study was to implement an in vivo Diffusion Tensor Imaging (DTI) protocol sensitive enough to detect structural sex differences in the adult zebra finch brain. Voxel-wise comparison of male and female DTI parameter maps shows clear differences in several components of the song control system (i.e. Area X surroundings, the high vocal center (HVC) and the lateral magnocellular nucleus of the anterior nidopallium (LMAN)), which corroborate previous findings and are in line with the clear behavioral difference as only males sing. Furthermore, to obtain additional insights into the 3-dimensional organization of the zebra finch brain and clarify findings obtained by the in vivo study, ex vivo DTI data of the male and female brain were acquired as well, using a recently established super-resolution reconstruction (SRR) imaging strategy. Interestingly, the SRR-DTI approach led to a marked reduction in acquisition time without interfering with the (spatial and angular) resolution and SNR which enabled to acquire a data set characterized by a 78μm isotropic resolution including 90 diffusion gradient directions within 44h of scanning time. Based on the reconstructed SRR-DTI maps, whole brain probabilistic Track Density Imaging (TDI) was performed for the purpose of super resolved track density imaging, further pushing the resolution up to 40μm isotropic. The DTI and TDI maps realized atlas-quality anatomical maps that enable a clear delineation of most components of the song control and auditory systems. In conclusion, this study paves the way for longitudinal in vivo and high-resolution ex vivo experiments aimed at disentangling [less ▲]

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See detailCabergoline for Cushing's disease: a large retrospective multicenter study.
Ferriere, A.; Cortet, C.; Chanson, P. et al

in European Journal of Endocrinology (2017), 176(3), 305-314

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of ... [more ▼]

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received cabergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism and adverse effects were recorded. RESULTS: Twenty-one (40%) of 53 patients who received cabergoline monotherapy had normal urinary free cortisol (UFC) values within 12 months (complete responders), and five of these patients developed corticotropic insufficiency. The fall in UFC was associated with significant reductions in midnight cortisol and plasma ACTH, and with clinical improvement. Compared to other patients, complete responders had similar median baseline UFC (2.0 vs 2.5xULN) and plasma prolactin concentrations but received lower doses of cabergoline (1.5 vs 3.5 mg/week, P < 0.05). During long-term treatment (>12 months), cabergoline was withdrawn in 28% of complete responders because of treatment escape or intolerance. Overall, sustained control of hypercortisolism was obtained in 23% of patients for 32.5 months (19-105). Nine patients on steroidogenesis inhibitors received cabergoline add-on therapy for 19 months (1-240). Hypercortisolism was controlled in 56% of these patients during the first year of treatment with cabergoline at 1.0 mg/week (0.5-3.5). CONCLUSIONS: About 20-25% of CD patients are good responders to cabergoline therapy allowing long-term control of hypercortisolism at relatively low dosages and with acceptable tolerability. No single parameter, including the baseline UFC and prolactin levels, predicted the response to cabergoline. [less ▲]

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See detailDo sex reversal procedures differentially affect agonistic behaviours and sex steroid levels depending on the sexual genotype in Nile tilapia?
Gennotte, Vincent ULg; Akonkwa, Balagizi; Mélard, Charles ULg et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (2017)

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY ... [more ▼]

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY males, XY and YY females, and XX males expressed higher level of aggressiveness that could be related to higher levels of 17β-oestradiol and 11-ketotestosterone respectively. Our results suggest that the presence of a Y chromosome increases aggressiveness in females. However, since the same relationship between aggressiveness and the Y chromosome is not observed in males, we can hypothesize that the differences in aggressiveness are not directly dependent on the genotype but on the sex reversal procedures applied on young fry during their sexual differentiation to produce these breeders. These hormonal treatments could have permanently modified the development of the brain and consequently influenced the behaviour of adults independently of their genotype. In both hypotheses (genotype or sex reversal influence), the causes of behavioural modifications have to be searched in an early modification of the brain sexual differentiation. [less ▲]

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See detailMetamemory Following Childhood Brain Injury: A Consequence of Executive Impairment
Geurten, Marie ULg; Chevignard, Mathilde; Kerrouche, Bernadette et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2017), 23(1), 67-82

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged ... [more ▼]

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged 7 to 14 years) who had sustained a moderate to severe TBI and 44 typically developing children were recruited. Children with TBI were divided into two groups according to the severity of their executive impairment. Injury severity was determined by the Glasgow Coma Scale (GCS) score on admission or by the duration of unconsciousness. All children were then tested on both their knowledge of general memory functioning and their level of memory self-awareness, respectively assessed using total number of correct responses on an adapted version of Kreutzer et al.’s metamemory interview and a self-other discrepancy score on a questionnaire evaluating everyday memory abilities. Data analyses revealed that participants with TBI who suffered impaired executive functions demonstrated less general metamemory knowledge, and underestimated the frequency of their memory problems, compared with children with TBI who had preserved executive functions and with control participants. Considering the well-established effect of metamemory knowledge on people’s spontaneous implementation of strategies, the interest and the importance of these findings on both theoretical and clinical grounds are discussed. [less ▲]

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See detailTemporal dynamics of soil microbial communities below the seedbed under two contrasting tillage regimes
Degrune, Florine; Theodorakopoulos, Nicolas; Colinet, Gilles ULg et al

in Frontiers in Microbiology (2017)

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See detailStudy of the photocatalytic activity of Fe3+, Cr3+, La3+ and Eu3+ single-doped and co-doped TiO2 catalysts produced by aqueous sol-gel processing
Malengreaux, Charline; Pirard, Sophie ULg; Léonard, Géraldine ULg et al

in Journal of Alloys and Compounds (2017), 691

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination ... [more ▼]

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination step, has been adapted to produce Fe3+, Cr3+, La3+ or Eu3+ single-doped TiO2 photocatalysts as well as La3+-Fe3+ and Eu3+-Fe3+ co-doped TiO2 catalysts. The physicochemical properties of the obtained catalysts have been characterized using a suite of complementary techniques, including ICP-AES, XRD, UV-Vis spectroscopy, nitrogen adsorption-desorption and Fe-57 Mössbauer. The active crystalline phase is obtained without requiring any calcination step and all the different catalysts are composed of nanocrystallites of anatase with a size of 6-7 nm and a high specific surface area varying from 181 to 298 m² g-1. In this study, the effect of the NO3:Ti(IV) mole ratio used to induce the peptisation reaction during the synthesis has been studied and the results revealed that this ratio can influence significantly the textural properties of the resulting catalyst. A screening of the photocatalytic activity of the undoped and Fe3+, Cr3+, La3+ or Eu3+ single-doped and co-doped photocatalysts has been performed by evaluating the degradation of 4-nitrophenol under UV-Visible light (330 nm < λ < 800 nm). This study suggests that the photocatalytic activity is significantly influenced by the dopant nature and content with an optimal dopant content being observed in the case of Fe3+ or La3+ single-doped as well as in the case of La3+-Fe3+ and Eu3+-Fe3+ co-doped catalysts. In the case of Cr3+ single-doped catalysts, a detrimental effect of the dopant on the photocatalytic degradation of 4-nitrophenol has been observed while no significant influence of the dopant has been detected in the case of Eu3+ single-doped catalysts. The role of the different dopants in modulating the photocatalytic activity is discussed. [less ▲]

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See detailMulticenter Evaluation of Cystatin C Measurement after Assay Standardization.
Bargnoux, Anne-Sophie; Pieroni, Laurence; Cristol, Jean-Paul et al

in Clinical Chemistry (2017), 63(4), 833-841

BACKGROUND: Since 2010, a certified reference material ERM-DA471/IFCC has been available for cystatin C (CysC). This study aimed to assess the sources of uncertainty in results for clinical samples ... [more ▼]

BACKGROUND: Since 2010, a certified reference material ERM-DA471/IFCC has been available for cystatin C (CysC). This study aimed to assess the sources of uncertainty in results for clinical samples measured using standardized assays. METHODS: This evaluation was performed in 2015 and involved 7 clinical laboratories located in France and Belgium. CysC was measured in a panel of 4 serum pools using 8 automated assays and a candidate isotope dilution mass spectrometry reference measurement procedure. Sources of uncertainty (imprecision and bias) were evaluated to calculate the relative expanded combined uncertainty for each CysC assay. Uncertainty was judged against the performance specifications derived from the biological variation model. RESULTS: Only Siemens reagents on the Siemens systems and, to a lesser extent, DiaSys reagents on the Cobas system, provided results that met the minimum performance criterion calculated according to the intraindividual and interindividual biological variations. Although the imprecision was acceptable for almost all assays, an increase in the bias with concentration was observed for Gentian reagents, and unacceptably high biases were observed for Abbott and Roche reagents on their own systems. CONCLUSIONS: This comprehensive picture of the market situation since the release of ERM-DA471/IFCC shows that bias remains the major component of the combined uncertainty because of possible problems associated with the implementation of traceability. Although some manufacturers have clearly improved their calibration protocols relative to ERM-DA471, most of them failed to meet the criteria for acceptable CysC measurements. [less ▲]

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See detailOrganocatalyzed coupling of carbon dioxide with epoxides for the synthesis of cyclic carbonates: catalyst design and mechanistic studies
Alves, Margot ULg; Grignard, Bruno ULg; Méreau, Raphaël et al

in Catalysis Science & Technology (2017), 7

The coupling of carbon dioxide (CO2) with epoxides with the formation of cyclic carbonates is a highly attractive 100% atom economy reaction. It represents a greener and safer alternative to the ... [more ▼]

The coupling of carbon dioxide (CO2) with epoxides with the formation of cyclic carbonates is a highly attractive 100% atom economy reaction. It represents a greener and safer alternative to the conventional synthesis of cyclic carbonates from diols and toxic phosgene. Today, cyclic carbonates find many applications as intermediates for fine chemicals synthesis, as electrolytes in Li-ion batteries, and polar aprotic solvents, but also serve for the synthesis of important polymers such as polycarbonates and polyurethanes. In view of their broad scope and their strong economic potential, there is a strong need to improve their synthesis and decrease their production costs. However, CO2 is a thermodynamically stable molecule, the use of catalysts is therefore mandatory for activating and facilitating the CO2/epoxide coupling reaction in a selective manner and under mild conditions. Recently organocatalysts deserved more and more interest in this field, and are viewed as alternatives to metal-based ones. Enormous progress has been made these last years to boost their performances, and some organocatalysts are now very competitive, cheap, readily available and exhibit good chemical stability towards moisture, water and air. This review is focusing on the recent advances in the development of metal-free organocatalysts for the synthesis of cyclic carbonates by CO2/epoxide coupling. Most of the state-of-the art organocatalysts used for this reaction are discussed, with a special emphasis to highlight the various routes employed to boost their performances. Their mode of action is also reported based on mechanistic considerations, supported by density functional theory (DFT) calculations that are becoming essential tools for modern catalysts design. Such detailed understanding of the mechanisms involving CO2 transformation should pave the way towards the definition of new modes of activation for converting CO2 with a large scope of substrates into various chemicals, monomers and polymers. [less ▲]

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See detailHow inclusive is inclusive recycling? Recyclers’ perspectives on a cross-sector partnership in Santiago de Chile
Giovannini, Michela; Huybrechts, Benjamin ULg

in Local Environment (2017)

Inclusive recycling is the inspiring slogan of a project relying on a cross- sector (public–private–civil society) partnership implemented in Latin America with the objective to improve the socioeconomic ... [more ▼]

Inclusive recycling is the inspiring slogan of a project relying on a cross- sector (public–private–civil society) partnership implemented in Latin America with the objective to improve the socioeconomic conditions of recyclers. Through a qualitative study in Santiago de Chile, this paper seeks to understand how inclusive inclusive recycling is, by assessing how organised recyclers perceive the goals, the process, and the outcomes of this project. The main findings converge in observing a general low inclusion of recyclers, but they also enable to decompose the notion of inclusion into three dimensions: “inclusive goals” refers to the extent to which the goals of the recyclers are taken into account when designing the collaboration project; “inclusive process” refers to the extent to which recyclers are involved in the process of implementing the project; and “inclusive outcomes” refers to the capacity of the partnership to acknowledge the achievements of recyclers organisations before (and during) the project and to take into account the ongoing local dynamics when evaluating the project. These findings contribute to better understand the position and challenges of recyclers in this type of partnership and more generally to shed light on the potential power imbalance in waste management cross-sector partnerships. [less ▲]

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See detailSacred Alliance or Pact with the Devil? How and Why Social Enterprises Collaborate with Mainstream Businesses in the Fair Trade Sector
Huybrechts, Benjamin ULg; Nicholls, Alex; Edinger, Katharina

in Entrepreneurship and Regional Development (2017), 29(7-8), 586-608

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises ... [more ▼]

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises interact with mainstream businesses and to what extent their collaboration patterns reflect a vision of how their social mission should be implemented and institutionalized. The empirical analysis is derived from a qualitative study of ‘fair trade’ – a hybrid model created by social enterprises and using market mechanisms to support small-scale producers in developing countries and to advocate for changes in international trading practices. The findings highlight three strategies used by fair trade social enterprises to manage their interactions with mainstream businesses: sector solidarity, selective engagement, and active appropriation. This paper suggests that each strategy is motivated by a different vision of how best to articulate the social mission of fair trade via specific types of collaborations. It also notes how each vision has a distinct pattern of institutionalization at the field level. This paper adds to the emergent literatures on social enterprise and social entrepreneurship, fair trade, cross-sector collaboration and hybrid organizing. [less ▲]

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See detailInhibition of ethylene synthesis reduces salt-tolerance in tomato wild relative species Solanum chilense
Gharbi, E.; Martínez, J.-P.; Benahmed, H. et al

in Journal of Plant Physiology (2017), 210

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of ... [more ▼]

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of Solanum chilense (accession LA4107) and of cultivated glycophyte Solanum lycopersicum (cv. Ailsa Craig) were cultivated for 7 days in nutrient solution containing 0 or 125 mM NaCl in the presence or absence of the inhibitor of ethylene synthesis (aminovinylglycine (AVG) 2 μM). Salt-induced ethylene synthesis in S. chilense occurred concomitantly with an increase in stomatal conductance, an efficient osmotic adjustment and the maintenance of carbon isotope discrimination value (Δ13C). In contrast, in S. lycopersicum, salt stress decreased stomatal conductance and Δ13C values while osmotic potential remained higher than in S. chilense. Inhibition of stress-induced ethylene synthesis by AVG decreased stomatal conductance and Δ13C in S. chilense and compromised osmotic adjustment. Solanum chilense behaved as an includer and accumulated high amounts of Na in the shoot but remained able to maintain K nutrition in the presence of NaCl. This species however did not stimulate the expression of genes coding for high-affinity K transport but genes coding for ethylene responsive factor ERF5 and JREF1 were constitutively more expressed in S. chilense than in S. lycopersicum. It is concluded that ethylene plays a key role in salt tolerance of S. chilense. © 2016 [less ▲]

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See detailQuand le Good Lives Model rencontre les travailleurs psychosociaux : une invitation à un changement de posture professionnelle
Corneille, Serge ULg; Devillers, Bérengère ULg

in Canadian Social Work Review = Revue Canadienne de Service Social (2017), Vol. 63(numéro 1),

Written by two professionals who work in this approach (and helped to make it known in the French-speaking world), this article presents the guidelines and specificity of Good Lives Model, especially when ... [more ▼]

Written by two professionals who work in this approach (and helped to make it known in the French-speaking world), this article presents the guidelines and specificity of Good Lives Model, especially when used by psychologists and social workers. Rédigé par deux professionnels qui travaillent avec cette approche (et ont contribué à la faire connaître dans la Francophonie), cet article présente les lignes directrices et la spécificité du Good Lives Model, en particulier lorsqu’utilisé par des intervenants psychosociaux. [less ▲]

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See detailHow to define, redefine or discredit a mineral species? E
Hatert, Frédéric ULg; Pasero, M; Mills, SJ et al

in Elements (2017), June 2017

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See detailEuropean Network for Neglected Vectors and Vector-Borne Infections COST Action Guidelines: What Is This About and What Is This For?
Charrel, Remi N.; Lempereur, Laetitia ULg; Mihalca, Andrei D. et al

in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2017), 17(1), 1

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See detailEffects of protein, essential amino acids, B-Hydroxy B-Methylbutyrate, creatine, Dehydroepiandrosterone and fatty acid supplementation on muscle mass, muscle strength and physical performance in older people aged 60 years and over. A systematic review of the litterature.
Beaudart, Charlotte ULg; Rabenda, Véronique ULg; Simmons, Michael et al

in Journal of Nutrition, Health & Aging (2017), (Online First),

Abstract: Objectives: The objective of this study was to perform a systematic review to investigate the effects protein, essential amino acids (EAA), β-hydroxy β-methylbutyrate (HMB), creatine ... [more ▼]

Abstract: Objectives: The objective of this study was to perform a systematic review to investigate the effects protein, essential amino acids (EAA), β-hydroxy β-methylbutyrate (HMB), creatine, dehydroepiandrosterone (DHEA) and fatty acid supplementation on muscle mass, muscle strength and physical performance of elderly subjects. Methods: Using the electronic databases MEDLINE and EMBASE we identified RCTs published until February 2016 which assessed the effects of these nutrient supplementation on muscle strength, muscle mass or physical performance. Study selection and data extraction were performed by two independent reviewers. Results: Search strategy allowed us to identify 23 RCTs. Among them, four used proteins as nutritional supplement, seven EAAs, six creatine, four DHEA and finally, two HMB. From our systematic review, it seems that the effects of these supplementations on muscle health are rather limited. Only consistent effects of EAA supplementation on physical performance (3 out of the 4 RCTs using EAA supplementation found significant effect of this supplementation on physical performance) and HMB supplementation on muscle mass (all the 2 identified RCTs using HMB supplementation found significant effect of this supplementation on muscle mass) have been found across studies. No consistent effects were found for the other types of dietary supplementation. Because of the important limitations in study design, inconsistency and lack of directness, the overall quality of the evidence was judged to be low or very low using the GRADE system. Conclusion: This systematic review showed a limited effect of nutritional supplementation on muscle mass, muscle power and physical function. Inconsistent positive effects were observed for some specific supplementations but the results only concerned one aspect of the muscle. Well designed and appropriately powered RCTs are needed to provide evidence for appropriate clinical recommendations. [less ▲]

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See detailTracking the Subtle Mutations Driving Host Sensing by the Plant Pathogen Streptomyces scabies
Jourdan, Samuel; Francis, Jourdan; Deflandre, Benoit et al

in mSphere (2017)

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See detailDeforestation drives functional diversity and fruit quality changes in a tropical tree assemblage
De Souza Pessoa, Michaele; Hambuckers, Alain ULg; Benchimol, Maíra et al

in Perspectives in Plant Ecology, Evolution and Systematics (2017), 28C

Functional traits associated with plant-animal interactions are essential for forest functionality, given that a higher diversity of fruit traits is likely to maintain a more diverse assemblage of ... [more ▼]

Functional traits associated with plant-animal interactions are essential for forest functionality, given that a higher diversity of fruit traits is likely to maintain a more diverse assemblage of frugivores and consequently promote the seed dispersal function. Yet, shade-intolerant species tend to persist in human-modified landscapes in the long term, which in turn is expect to reduce fruit trait diversity. Here we evaluate how forest cover at the landscape-scale influences the functional diversity of fruit traits, considering the zoochoric tree community and two regeneration strategies separately (shade-tolerant and shade-intolerant species). We sampled 20 forest remnants in the Brazilian Atlantic Forest, located in landscapes with forest cover ranging from 2 to 93 %. In each remnant, we established five plots of 25 x 4 m and marked all trees ≥ 5 cm diameter at breast height (DBH). We compared morphological and chemical attributes of fleshy fruits directly related to the attraction of frugivores, and evaluated the similarity of the zoochoric tree assemblage composition along the forest cover gradient, taking into account the two regeneration strategies. We calculated four functional indices (richness, evenness, divergence, and community-level weighted means of trait values) and used either linear models or spatial mixed linear models to evaluate the effects of forest cover on functional diversity. Our main results revealed that forest cover loss has negatively affected fruit functional diversity for the overall zoochoric community. Forest cover loss also affected functional richness and functional eveness for total and shade-tolerant species, and was positively correlated with the content of protein and lipid in fruits of shade-intolerant species. Additionally, sites exhibiting a lower amount of forest cover showed greater compositional similarity among shade intolerant species but reduced similarity among shade-tolerant species. We conclude that patterns of species reassembly triggered by landscape-scale deforestation decreases the capacity of the remaining forest for provisioning food resources for frugivore assemblages. The maintenance of shade-tolerant species is pivotal in deforested areas, since their fruit quality is not offset by shade-intolerant species. This is particularly important, mainly because shade-intolerant species are those still persisting in disturbed forests; however, their presence will not provide the same food quality supplied by those species lost. [less ▲]

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See detailSimultaneous analysis of nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry.
Huang, Yang; Zhang, Tingting; Zhao, Yumei et al

in Journal of Pharmaceutical & Biomedical Analysis (2017)

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ... [more ▼]

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ginseng extracts. Few analytical methods have been developed so far to simultaneously analyze these three classes of compounds with different polarities present in ginseng extracts. In the present study, a simple and efficient analytical method was successfully developed for the simultaneous separation of 17 nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry (SFC-MS). The effect of various experimental factors on the separation performance, such as the column type, temperature and backpressure, the type of modifier and additive, and the concentration of make-up solvent were systematically investigated. Under the selected conditions, the developed method was successfully applied to the quality evaluation of 14 batches of ginseng extracts from different origins. The results obtained for the different batches indicate that this method could be employed for the quality assessment of ginseng extracts. [less ▲]

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See detailPreliminary JIRAM results from Juno polar observations: 2. Analysis of the Jupiter southern H3 + emissions and comparison with the north aurora
Adriani, Alberto; Mura, Alessandro; Moriconi, M. L. et al

in Geophysical Research Letters (2017), 44(10), 4633-4640

The Jupiter InfraRed Auroral Mapper (JIRAM) aboard Juno observed the Jovian South Pole aurora during the first orbit of the mission. H3 + (trihydrogen cation) and CH4 (methane) emissions have been ... [more ▼]

The Jupiter InfraRed Auroral Mapper (JIRAM) aboard Juno observed the Jovian South Pole aurora during the first orbit of the mission. H3 + (trihydrogen cation) and CH4 (methane) emissions have been identified and measured. The observations have been carried out in nadir and slant viewing both by a L-filtered imager and a 2–5 μm spectrometer. Results from the spectral analysis of the all observations taken over the South Pole by the instrument are reported. The coverage of the southern aurora during these measurements has been partial, but sufficient to determine different regions of temperature and abundance of the H3 + ion from its emission lines in the 3–4 μm wavelength range. Finally, the results from the southern aurora are also compared with those from the northern ones from the data taken during the same perijove pass and reported by Dinelli et al. (2017). ©2017. American Geophysical Union. All Rights Reserved. [less ▲]

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See detailFlavor profiles of monovarietal virgin olive oils produced in the Oriental region of Morocco
Mansouri, Farid; Ben Moumen, Abdessamad; Richard, Gaetan ULg et al

in Oilseeds and fats, Crops and Lipids (2017), 24

The purpose of this study is the evaluation of flavor profiles of monovarietal virgin olive oils (VOO) produced in the Oriental region of Morocco via the characterization of volatile compounds, using SPME ... [more ▼]

The purpose of this study is the evaluation of flavor profiles of monovarietal virgin olive oils (VOO) produced in the Oriental region of Morocco via the characterization of volatile compounds, using SPME-GC/MS technique, and the determination of total phenolic content (colorimetric method). The study concerns oils of three European olive cultivars (Arbosana, Arbequina and Koroneiki) which were recently introduced in Morocco under irrigated high-density plantation system. GC/MS aroma profiles of analyzed VOOs showed the presence of 35 volatile compounds. The major compounds in such oils are C6 compounds produced from linoleic and linolenic acids via lipoxygenase pathway such as trans-2-hexenal, cis-2-hexenal, cis-3-hexen-1-ol, trans-3-hexen-1-ol, trans-3-hexen-1-ol acetate, hexanal and 1-hexanol in different proportions depending on the cultivar (p<0.05). In addition, statistical analyses indicate that the analyzed VOOs have different aroma profiles. Arbequina oil has a high proportion of compounds with sensory notes “green” and “sweet” giving it a fruity sensation compared to Arbosana and Koroneiki. In parallel, Arbosana and Koroneiki oils are rich in phenolic compounds and provide relatively bitter and pungent tastes to these oils. [less ▲]

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See detailHow clinical practitioners assess frailty in their daily practice: an international survey
Bruyère, Olivier ULg; Buckinx, Fanny ULg; Beaudart, Charlotte ULg et al

in Aging Clinical and Experimental Research (2017), (On line),

NTRODUCTION: Various operational definitions have been proposed to assess the frailty condition among older individuals. Our objective was to assess how practitioners measure the geriatric syndrome of ... [more ▼]

NTRODUCTION: Various operational definitions have been proposed to assess the frailty condition among older individuals. Our objective was to assess how practitioners measure the geriatric syndrome of frailty in their daily routine. METHODS: An online survey was sent to national geriatric societies affiliated to the European Union Geriatric Medicine Society (EUGMS) and to members of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). RESULTS: A total of 388 clinicians from 44 countries answered to the survey. Most of them were medical doctors (93%), and their primary field of practice was geriatrics (83%). Two hundred and five clinicians (52.8%) always assessed frailty in their daily practice, 38.1% reported to "sometimes" measure it, and 9.1% never assess it. A substantial proportion of clinicians (64.9%) diagnose frailty using more than one instrument. The most widely used tool was the gait speed test, adopted by 43.8% of the clinicians, followed by clinical frailty scale (34.3%), the SPPB test (30.2%), the frailty phenotype (26.8%) and the frailty index (16.8%). CONCLUSION: A variety of tools is used to assess frailty of older patients in clinical practice highlighting the need for standardisation and guidelines. [less ▲]

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See detailComparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure
Bertrand, Henri ULg; Springer, Svenja; Burnside, Wesley et al

in Laboratory Animals (2017)

Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery ... [more ▼]

Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery than iso- flurane in a number of species, but no comparisons have been made in non-human primates. This study compared the recovery characteristics of isoflurane and sevoflurane in rhesus macaques undergoing experi- mental neurosurgery. Twelve primates (7 males and 5 females) were randomly allocated to the treatment groups. They were sedated with ketamine (10 mg/kg) and anaesthesia was induced with propofol (usually 8 mg/kg intravenously [IV]). Anaesthesia was maintained with either sevoflurane (SEVO) (2.2 0.4%) or iso- flurane (ISO) (1.2 0.2%) and alfentanil (0.2–0.5 mg/kg/min IV) for 332–592 min. Animals were mechanically ventilated. Meloxicam (0.3mg/kg) and methylprednisolone infusion (5.4mg/kg/h) were also administered. Time to extubation after cessation of anaesthesia was significantly shorter with sevoflurane (ISO: 7.0 1.8 min; SEVO: 3.6 1.5; *P 1⁄4 0.005) as was the time to the animal sitting unaided (ISO: 15.7 8.2 min; SEVO: 7.1 1.7min; *P1⁄40.004). No significant difference in the quality of recovery following isoflurane or sevoflurane anaesthesia was found. In conclusion, isoflurane and sevoflurane are both suitable volatile agents for the maintenance of general anaesthesia in rhesus macaques undergoing experimental neurosur- gical procedures. The two volatile agents presented a similar emergence quality profile, however sevoflurane anaesthesia was associated with a faster recovery, offering the possibility of conducting earlier post-operative neurological assessment. [less ▲]

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See detailImaging of Vanadium in Microfossils: A New Potential Biosignature
Marshall, C.P.; Marshall, A.O.; Aitken, J.B. et al

in Astrobiology (2017), 17(11), 1-8

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See detailA new Late Devonian isoetalean lycopsid from New South Wales, Australia: Cymastrobus irvingii gen. et sp. nov.
Evreïnoff, M.; Meyer-Berthaud, B.; Decombeix, A.-L. et al

in Palaeontologia Electronica (2017), 20.3.45A

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See detailPrestation du serment de Socrate : promotion 2015-2016
Simons, Germain ULg; Beckers, Jacqueline ULg; De Croix, Séverine et al

in Didactiques en Pratique (2017), 3

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See detailFire resistance of DELTABEAM® composite beams: a numerical investigation
Maraveas, Chrysanthos ULg

in Journal of Structural Fire Engineering (2017)

Purpose – The DELTA® beam composite floor system is a recently developed shallow floor type that has seen many applications in contemporary construction. It involves partially encasing DELTA® steel beams ... [more ▼]

Purpose – The DELTA® beam composite floor system is a recently developed shallow floor type that has seen many applications in contemporary construction. It involves partially encasing DELTA® steel beams in concrete, with the lower flange remaining exposed. Besides the satisfactory behavior of the system at ambient conditions, understanding its response under elevated temperatures is critical in evaluating its overall performance. Despite certification from the manufacturing company that the system has adequate fire resistance, its behavior under fire conditions has neither been investigated to depth nor reported in detail. The purpose of this paper is the detailed numerical investigation of their behavior in fire. For this reason, the finite element method was implemented in this paper to simulate the response of such beams subjected to fire. Material properties were modeled according to the Eurocodes. The coupled thermal-structural parametric analyses involved four different variations of the “shortest” and “deepest” cross-section (eight case studies in total) specified by the manufacturing company. Other simulations of these cross-sections, in which either the thermal expansion or the structural load were not taken into account, were carried out for comparison purposes. Design/methodology/approach – The methodology for simulating such systems, which has been successfully implemented and validated against fire test results elsewhere (Maraveas et al., 2012) was also followed here. To investigate the statement made by Maraveas et al. (2014) and the equations proposed by Zaharia and Franssen (2012) that the insulation is not so effective for “short” cross-sections, two beams, one with a D20-200 (Deltabeam Technical Manual, 2013) cross-section (shallowest section) and one with a D50-600 (Deltabeam Technical Manual, 2013) cross-section (deepest section), were simulated in this paper for comparison purposes. Additionally, reasonable assumptions were made for the cross-sectional dimensions not specified by the manufacturer (Deltabeam Technical Manual, 2013) and parametric analyses were carried out to investigate their effect on the structural response of the system. Findings – Composite DELTA® beams can achieve fire resistances ranging from 120 to 180 min, depending on the depth and geometry of their cross-section, with deeper sections displaying a better fire response. The intense thermal bowing that occurs when these beams are heated from below has a more pronounced effect, in terms of thermally induced deflections for deeper sections. The satisfactory fire resistance of these beams is achieved due to the action of the concrete encased web and the reinforcement which compensate for the loss of the exposed lower flange. Increasing the thickness of the web in deeper sections improves their fire rating up to 180 min. The thickness of the lower flange affects the fire rating of the beams only in a minor way. Practical/implications – The paper describes a numerical methodology to estimate the fire resistance of complex flooring systems. [less ▲]

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See detailAssessment of extreme value overestimations with equivalent static wind loads
Blaise, Nicolas ULg; Andrianne, Thomas ULg; Denoël, Vincent ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2017)

The wind-resistant design using equivalent static wind loads is convenient for structural engineers. This paper studies the reliability of such an approach in the case of non-Gaussianities in both ... [more ▼]

The wind-resistant design using equivalent static wind loads is convenient for structural engineers. This paper studies the reliability of such an approach in the case of non-Gaussianities in both aerodynamic pressures and responses. These non-Gaussianities are responsible for overestimations of envelope values and may result in uneconomical designs, if not appropriately understood, assessed and addressed. In this study, it is shown that the equivalent static wind loads defined with the Conditional Expected Load method, which extends the physical meaning of the Load-Response Correlation approach in a non-Gaussian framework, improves the issue of overestimations of envelope values. Several envelopes of structural responses are considered: the mean of extremes and the 86% quantiles of extremes, together with two reference periods (10 min and 1 h). Extensive wind tunnel measurements have been collected, which correspond to 371 h full scale. This study is undertaken for quasi-static analysis of structures and is illustrated with a low-rise building. [less ▲]

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See detailPEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of HDAC5 siRNA in Cancer Therapy
Frère, Antoine ULg; Baroni, Alexandra; Hendrick, Elodie ULg et al

in ACS Applied Materials and Interfaces (2017), 25(9(3)), 2181-2195

Guanidine and morpholine functionalized aliphatic polycarbonate polymers are able to efficiently deliver histone deacetylase 5 (HDAC5) siRNA into the cytoplasm of cancer cells in vitro leading to a ... [more ▼]

Guanidine and morpholine functionalized aliphatic polycarbonate polymers are able to efficiently deliver histone deacetylase 5 (HDAC5) siRNA into the cytoplasm of cancer cells in vitro leading to a decrease of cell proliferation were previously developed. To allow these biodegradable and biocompatible polyplex nanoparticles to overcome the extracellular barriers and be effective in vivo after an intravenous injection, polyethylene glycol chains (PEG750 or PEG2000) were grafted on the polymer structure. These nanoparticles, showed an average size of about 150 nm and a slightly positive zeta potential with complete siRNA complexation. Behavior of PEGylated and non-PEGylated polyplexes were investigated in the presence of serum, in terms of siRNA complexation (Fluorescence Correlation Spectroscopy), size (Dynamic Light Scattering and Single-Particle Tracking), interaction with proteins (Isothermal Titration Calorimetry) and cellular uptake. Surprisingly, both PEGylated and non-PEGylated formulations presented relatively good behavior in the presence of fetal bovine serum (FBS). Hemocompatibility tests showed no effect of these polyplexes on hemolysis and coagulation. In vivo biodistribution in mice was performed and showed a better siRNA accumulation at the tumor site for PEGylated polyplexes. However, cellular uptake in protein-rich conditions showed that PEGylated polyplex lost their ability to interact with biological membranes and enter into cells, showing the importance to perform in vitro investigations in physiological conditions closed to in vivo situation. In vitro, the efficiency of PEGylated nanoparticles decreases compared to non-PEGylated particles, leading to the loss of the antiproliferative effect on cancer cells. [less ▲]

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See detailCan Fe isotope fractionations trace the pedogenetic mechanisms involved in podzolization?
fekiakova, zuzana; vermeire, marie-liesse; bechon, L et al

in Geoderma (2017), 296

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See detailMacroevolution of Specificity in Cyanolichens of the Genus Peltigera Section Polydactylon (Lecanoromycetes, Ascomycota)
Magain, Nicolas ULg; Miadlikoswka, Jolanta; Goffinet, Bernard et al

in Systematic Biology (2017), 66(1), 74-99

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See detailMisrecollection prevents older adults from benefitting from semantic relatedness of the memoranda in associative memory
Delhaye, Emma ULg; Tibon, Roni; Gronau, Nurit et al

in Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition (2017)

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See detailInfluence of corn variety, drying temperature and moisture content at harvest on the saccharides released during an in vitro pepsin-pancreatin digestion
Odjo, Sylvanus; Huart, François ULg; Bera, François ULg et al

in Starch-Stärke (2017)

High-Performance Anion-Exchange Chromatography Coupled with Pulsed Amperometric Detection (HPAEC-PAD) was used to quantify and to determine the nature of saccharides released after the digestion of two ... [more ▼]

High-Performance Anion-Exchange Chromatography Coupled with Pulsed Amperometric Detection (HPAEC-PAD) was used to quantify and to determine the nature of saccharides released after the digestion of two corn grains submitted to different drying and harvesting protocols. Five saccharides were quantified: glucose, maltose, isomaltose, maltotriose and glucosyl-maltotriose. After a subsequent hydrolysis with amyloglucosidase of the released sugar, the amount of total glucose recovered increased with the increase in drying temperature and the moisture content of grain at harvest. These results suggest that structural changes induced within corn starch granules during drying affect their hydrolysis by amylases. These changes may lead to different pathways of sugar absorption in the small intestine of monogastrics. Thus, corn grains with a similar composition may lead to different levels of metabolizable energy upon gastro-intestinal digestion. [less ▲]

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See detailCoherent backscattering in the Fock space of ultracold bosonic atoms
Schlagheck, Peter ULg; Dujardin, Julien

in Annalen der Physik (2017), 529

We present numerical evidence for the occurrence of coherent backscattering in the Fock space of a small disordered Bose-Hubbard system consisting of four sites and containing five particles. This many ... [more ▼]

We present numerical evidence for the occurrence of coherent backscattering in the Fock space of a small disordered Bose-Hubbard system consisting of four sites and containing five particles. This many-body interference phenomenon can most conveniently be seen in time evolution processes that start from a Fock state of the Bose-Hubbard system. It manifests itself in an enhanced detection probability of this initial state as compared to other Fock states with comparable total energy. We argue that coherent backscattering in Fock space can be experimentally measured with ultracold bosonic atoms in optical lattices using state-of-the-art single-site detection techniques. A synthetic gauge field can be induced in order to break time-reversal symmetry within the lattice and thereby destroy coherent backscattering. While this many-body interference effect is most prominently visible in the presence of eigenstate thermalization, we briefly discuss its significance in the opposite regime of many-body localization. [less ▲]

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See detailSingle- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.
Baron, Frédéric ULg; Ruggeri, Annalisa; Beohou, Eric et al

in Journal of Hematology & Oncology (2017), 10(1), 128

BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of ... [more ▼]

BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of two CB units from different partially HLA-matched donors (double CBT) is frequently performed in patients who lack a sufficiently rich single CB unit. METHODS: We compared CBT outcomes in patients given single or double CBT following reduced-intensity conditioning (RIC) in a retrospective multicenter registry-based study. Inclusion criteria included adult (>/=18 years) patients, acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL), complete remission (CR) at the time of transplantation, first single (with a cryopreserved TNC >/= 2.5 x 107/kg) or double CBT between 2004 and 2014, and RIC conditioning. RESULTS: Data from 534 patients with AML (n = 408) or ALL (n = 126) receiving a first single (n = 172) or double (n = 362) CBT were included in the analyses. In univariate analysis, in comparison to patients transplanted with a single CB, double CB recipients had a similar incidence of neutrophil engraftment but a suggestion for a higher incidence of grade II-IV acute GVHD (36 versus 28%, P = 0.08). In multivariate analyses, in comparison to single CBT recipients, double CBT patients had a comparable incidence of relapse (HR = 0.9, P = 0.5) and of nonrelapse mortality (HR = 0.8, P = 0.3), as well as comparable overall (HR = 0.8, P = 0.17), leukemia-free (HR = 0.8, P = 0.2) and GVHD-free, relapse-free (HR = 1.0, P = 0.3) survival. CONCLUSIONS: These data failed to demonstrate better transplantation outcomes in adult patients receiving double CBT in comparison to those receiving single CBT with adequate TNC after RIC. [less ▲]

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See detailEtude gemmologique de la croix-reliquaire à double traverse du Trésor de la Cathédrale de Liège
Demaude, Merry ULg; Bruni, Yannick ULg; Hatert, Frédéric ULg et al

in Bulletin trimestriel du Trésor de Liège (2017), 50

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See detailInvestigation of the added mass method for seismic design of lock gates
Buldgen, Loïc ULg; Le Sourne, Hervé; Caprace, Jean-David ULg et al

in Engineering Structures (2017)

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See detailInteractive effects of ultraviolet radiation and thermal stress on two reef-building corals
Courtial, Lucile; Roberty, Stéphane ULg; Shick, Malcom et al

in Limnology and Oceanography (2017)

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See detailInfluence of sawdust addition on drying of wastewater sludges: Comparison of structural characteristics
Li, Jie; Plougonven, Erwan ULg; Fraikin, Laurent ULg et al

in Drying Technology (2017), 35(8), 925-932

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See detailA comparative study on optimum insulation thickness of walls and energy savings in equatorial and tropical climate
Nematchoua, Modeste Kameni; Ricciardi, Paola; Reiter, Sigrid ULg et al

in International Journal of Sustainable Built Environment (2017)

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well ... [more ▼]

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well that energy supply does not always satisfy demand. Thermal insulation technology can be one of the leading methods for reducing energy consumption in these new buildings. However, choosing the thickness of the insulation material often causes high insulation costs. In the present study, the optimum insulation thickness, energy saving and payback period were calculated for buildings in Yaounde´ and Garoua cities, located in two climatic regions in Cameroon. The economic model including the cost of insulation material and the present value of energy consumption and the cost over a life time of 22 years of the building, were used to find the optimum insulation thickness, energy saving, and payback period. Materials that extruded polystyrene were chosen and used for two typical wall structures (concrete block (HCB) and compressed stabilized earth block wall (CSEB)). The early cooling transmission loads, according to wall orientations and percentage of radiation blocked were calculated using the explicit finite-difference method under steady periodic conditions. As a result, it was found that the west- and east-facing walls are the least favourite in the cooling season, whereas the south and north orientations are the most economical. Although wall orientation had a significant effect on the optimum insulation thickness, it had a more significant effect on energy savings. In equatorial region (Yaounde´), for south orientation, the optimum insulation thickness was 0.08 m for an energy savings of 51.69 $/m2. Meanwhile, in tropical region (Garoua), for north orientation, the optimum insulation thickness was 0.11 m for an energy savings of 97.82 $/m2. [less ▲]

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See detailEmbedded solids of any dimension in the X-FEM. Part I - Building a dedicated P1 function space
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape ... [more ▼]

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape functions, it introduces an algorithm to reduce the function space into an equivalent space having the same properties than a P1 Lagrange approximation. Convergence studies involving problems of codimension one or two embedded in 2D or 3D show good accuracy with regard to classical finite element and analytical solutions. The effects of the relative position of the domain with respect to the mesh are studied in a sensitivity analysis; it illustrates how the proposed solution allows to keep the condition number bounded. A comparative study is performed with the method introduced by Olshanskii et al. 2009 on a closed surface to validate our approach. The robustness of the proposed approach is investigated with regard to their method and that of Burman et al. 2016. This paper is the first in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. It investigates problems involving borderless domains or domains with boundary subject to Dirichlet constraint defined only on the boundaries of the bulk mesh, while the forthcoming paper overcomes this limitation by introducing a new stable Lagrange multiplier space for Dirichlet boundary condition (and more generally stiff condition), that is valid for every combination of the background mesh and manifold dimensions. The combination of both algorithms allows to handle any embedding i.e. 1D, 2D and 3D problems embedded in 2D or 3D background meshes. [less ▲]

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See detailGeneralisability of a Virtual Trials Method for Glycaemic Control in Intensive Care.
Dickson, Jennifer L.; Stewart, Kent W.; Pretty, Christopher G. et al

in IEEE transactions on bio-medical engineering (2017)

BACKGROUND: Elevated blood glucose (BG) concentrations (Hyperglycaemia) are a common complication in critically ill patients. Insulin therapy is commonly used to treat hyperglycaemia, but metabolic ... [more ▼]

BACKGROUND: Elevated blood glucose (BG) concentrations (Hyperglycaemia) are a common complication in critically ill patients. Insulin therapy is commonly used to treat hyperglycaemia, but metabolic variability often results in poor BG control and low BG (hypoglycaemia). OBJECTIVE: This paper presents a model-based virtual trial method for glycaemic control protocol design, and evaluates its generalisability across different populations. METHODS: Model-based insulin sensitivity (SI) was used to create virtual patients from clinical data from three different ICUs in New Zealand, Hungary, and Belgium. Glycaemic results from simulation of virtual patients under their original protocol (self-simulation) and protocols from other units (cross-simulation) were compared. RESULTS: Differences were found between the three cohorts in median SI and inter-patient variability in SI. However, hour-to-hour intra-patient variability in SI was found to be consistent between cohorts. Self and cross-simulation results were found to have overall similarity and consistency, though results may differ in the first 24-48 hours due to different cohort starting BG and underlying SI. CONCLUSIONS AND SIGNIFICANCE: Virtual patients and the virtual trial method were found to be generalisable across different ICUs. This virtual trial method is useful for in silico protocol design and testing, given an understanding of the underlying assumptions and limitations of this method. [less ▲]

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See detailAllelic variation in TLR4 is linked to resistance to Salmonella Enteritidis infection in chickens.
Li, Peng; Wang, Huihua; Zhao, Xingwang et al

in Poultry Science (2017)

Salmonella Enteritidis (SE) is a foodborne pathogen that negatively affects both animal and human health. Polymorphisms of the TLR4 gene may affect recognition by Toll-like receptor 4 (TLR4) of bacterial ... [more ▼]

Salmonella Enteritidis (SE) is a foodborne pathogen that negatively affects both animal and human health. Polymorphisms of the TLR4 gene may affect recognition by Toll-like receptor 4 (TLR4) of bacterial lipopolysaccharide (LPS), leading to differences in host resistance to pathogenic infections. The present study has investigated polymorphic loci of chicken TLR4 (ChTLR4) in ten chicken breeds, electrostatic potentials of mutant structures of TLR4, and a linkage analysis between allelic variation and survival ratio to infection with SE in specific-pathogen-free (SPF) White Leghorns. A total of 19 Single Nucleotide Polymorphisms (SNPs), of which 10 were novel, were found in chicken breeds. Seven newly identified amino acid variants (C68G, G674A, G782A, A896T, T959G, T986A, and A1104C) and previously reported important mutations (G247A, G1028A, C1147T, and A1832G) were demonstrated in the extracellular domain of the ChTLR4 gene. Significant changes in surface electrostatic potential of the ectodomain of TLR4, built by homology modeling, were observed at the Glu83Lys (G247A), Arg298Ser (A896T), Ser368Arg (A1104C), and Gln611Arg (A1832G) substitutions. Linkage analysis showed that one polymorphic locus G247A of TLR4 gene, common in all breeds examined, was significantly associated with increased resistance to SE in SPF White Leghorns chicks (log-rank P-value = 0.04). The genotypes from A1832G SNPs did not show statistically significant survival differences. This study has provided the first direct evidence that G247A substitution in ChTLR4 is associated with increased resistance to Salmonella Enteritidis. [less ▲]

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See detailChild Safety Reference Frameworks: a Policy Tool for Child Injury Prevention at the Sub-national Level
Scholtes, Béatrice ULg; Schröder-Bäck, Peter; MacKay, Morag et al

in Central European Journal of Public Health (2017), 25(2), 120-128

Objectives: The aim of this paper is to present the Child Safety Reference Frameworks (CSRF), a policy advice tool that places evidence-based child safety interventions, applicable at the sub-national ... [more ▼]

Objectives: The aim of this paper is to present the Child Safety Reference Frameworks (CSRF), a policy advice tool that places evidence-based child safety interventions, applicable at the sub-national level, into a framework resembling the Haddon Matrix. Method: The CSRF is based on work done in previous EU funded projects, which we have adapted to the field of child safety. The CSRF were populated following a literature review. Results: Four CSRF were developed for four domains of child safety: road, water and home safety, and intentional injury prevention. Conclusion: The CSRF can be used as a reference, assessment and comparative tool by child safety practitioners and policy makers working at the sub-national level. [less ▲]

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See detailVolumetric absorptive microsampling: Current advances and applications.
Kok, Miranda ULg; Fillet, Marianne ULg

in Journal of Pharmaceutical & Biomedical Analysis (2017)

Recently, volumetric absorptive microsampling (VAMS) has been introduced for the sampling of biological fluids, and more particularly whole blood, on a porous hydrophilic tip. VAMS enables the collection ... [more ▼]

Recently, volumetric absorptive microsampling (VAMS) has been introduced for the sampling of biological fluids, and more particularly whole blood, on a porous hydrophilic tip. VAMS enables the collection of small, accurate and precise blood volumes (10 or 20muL) regardless of the hematocrit. After drying, the samples can be stored or directly analyzed. The stability of various compounds in dried samples supported on VAMS tips varies from one day to a few months at room temperature, and increases at lower temperatures. The complete tip is used during a simple and straightforward sample preparation. Compounds can be extracted with a variety of solvents, and thereafter directly analyzed. A design of experiments is recommended to determine the optimal extraction conditions for a reproducible recovery. The recovery of compounds might be influenced by the hematocrit. In the last two years, various pharmacokinetic and therapeutic drug monitoring studies have been conducted with VAMS. This review covers the general aspects related with the use of VAMS and its applicability is demonstrated through examples. [less ▲]

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See detailLes droits d'enregistrement
Bourgeois, Marc ULg; Douny, Raphaël ULg; Chauvin, N. et al

in Chronique de Droit à l'Usage du Notariat (2017), 65

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See detailLa circulation du livre médical dans les anciens Pays-Bas au second tiers du XVIe siècle
Adam, Renaud ULg

in Histoire des Sciences Médicales (2017), 51(1), 47-59

In the years 1565-1566, the Low Countries were shaken by a vast politico-religious revolt directed against Philip II. In response to the uprising and misbehaviour of parts of the population, the king ... [more ▼]

In the years 1565-1566, the Low Countries were shaken by a vast politico-religious revolt directed against Philip II. In response to the uprising and misbehaviour of parts of the population, the king established the so-called Council of Troubles, a special court active from 1567 to 1576. This institution was led in its early years by Fernando Àlvarez de Toledo, Duke of Alba and Governor General of the Low Countries. The Council of Troubles had a very close look at the production, the distribution as well as at the possession of books. At the request of the Duke of Alba, inquisitors were sent during the spring and summer of 1569 in various provinces of the Low Countries still under Spanish rule to examine bookshops and find out heretical books. These archives offer a sort of radioscopy of the book market of the Low-Countries on the eve of the Counter-Reformation. We will focus here on the situation of the city of Mons, in the county of Hainaut. The book lists written by the Duke of Alba’s emissaries describe more than 1600 books. The descriptions of the books found there are extremely high: names of authors, title, place and date of printing. The care and rigour shown by the notary in the performance of his task make this source a valuable document to study the book market in Hainaut in the second third of the 16th century and, more specifically, to study the medical book market. We will be able to discover which authors and which genres are preferred, the importance of the scientific literature compared with the popular literature, and the origin of these books. [less ▲]

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See detailVaginocutaneous fistula and buttock abscess formation 7 years after polypropylene transobturator tape insertion.
ABDALLAH, Alain; NISOLLE, Michelle ULg; DE LANDSHEERE, Laurent ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2017), 46

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including ... [more ▼]

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including infections, abscess and fistula formation. Here we report a case of 57 year old female who presented with abscess and left vaginocutaneous buttock fistula 7 years after transobturator polypropelene tape insertion. Treatment included abscess drainage with dissection of the fistulous tract and removal of the left arm of the transobturator tape along with antibiotic coverage. Sinus drainage stopped after 3 days. Stress urinary incontinence didn't recur. Suspicion of fistula formation should rise in patients presenting with bothersome vaginal or cutaneous discharge after transobturator tape insertion. This case is particular since it describes a fistula complication with polypropelene tape which is unusual with this type of tapes. Treatment of such complication should always consist of surgical removal of the mesh to allow closure of the fistulous tract. [less ▲]

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See detailAssessment and Retrofit of the Bridge over Kouris River, Cyprus
Maraveas, Chrysanthos ULg; Tassiouli, Konstantina

in Open Journal of Civil Engineering (2017)

The main objective of the present study is the assessment and retrofit of an existing road bridge that is located in Cyprus over the river Kouris. In particular the study concerns in a road bridge with ... [more ▼]

The main objective of the present study is the assessment and retrofit of an existing road bridge that is located in Cyprus over the river Kouris. In particular the study concerns in a road bridge with seven spans of 10.5 m + 5 * 12.6 m + 10.5 m, a cross section width of 7.10 m and a 5 m piers height that was constructed in the early 50’s. The structural system of the bridge comprises of cast in situ reinforced concrete T-beams and slab deck that is simply supported on masonry piers. According to the new urban plan to design the bridge should now accommodate two lanes per direction, a pedestrian walkway and a cycling lane with total cross section width of new deck 15.60 m. The deck of the bridge widened using for aesthetic reasons the same cross section type and the new T-Beams and slab deck connected monolithically to the existing one. The existing part of the deck was strengthened with reinforced concrete jacketing due to inadequacy in shear resistance. Major challenge of the project posed the existing masonry pier layout that was insufficient to carry the new design seismic forces. New piers, founded on piles, were designed adjacent to the existing piers in order to support the new widened part of the bridge, and also to bear all the horizontal loads arising from the masses of the total deck. Sliding bearings (free movement) placed in the part of the bridge over the existing piers and elastomeric bearings with movement only in the longitudinal direction placed in the new piers. [less ▲]

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See detailDevelopment of an analytical method for crystalline content determination in amorphous solid dispersions produced by Hot-Melt Extrusion using transmission Raman spectroscopy: A feasibility study.
Netchacovitch, Lauranne ULg; Dumont, Elodie ULg; Cailletaud, Johan ULg et al

in International Journal of Pharmaceutics (2017), 530(1-2), 249-255

The development of a quantitative method determining the crystalline percentage in an amorphous solid dispersion is of great interest in the pharmaceutical field. Indeed, the crystalline Active ... [more ▼]

The development of a quantitative method determining the crystalline percentage in an amorphous solid dispersion is of great interest in the pharmaceutical field. Indeed, the crystalline Active Pharmaceutical Ingredient transformation into its amorphous state is increasingly used as it enhances the solubility and bioavailability of Biopharmaceutical Classification System class II drugs. One way to produce amorphous solid dispersions is the Hot-Melt Extrusion (HME) process. This study reported the development and the comparison of the analytical performances of two techniques, based on backscattering and transmission Raman spectroscopy, determining the crystalline remaining content in amorphous solid dispersions produced by HME. Principal Component Analysis (PCA) and Partial Least Squares (PLS) regression were performed on preprocessed data and tended towards the same conclusions: for the backscattering Raman results, the use of the DuoScan™ mode improved the PCA and PLS results, due to a larger analyzed sampling volume. For the transmission Raman results, the determination of low crystalline percentages was possible and the best regression model was obtained using this technique. Indeed, the latter acquired spectra through the whole sample volume, in contrast with the previous surface analyses performed using the backscattering mode. This study consequently highlighted the importance of the analyzed sampling volume. [less ▲]

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See detailEffects of the conversion of intensive grasslands into Christmas tree plantations on bird assemblages
Gailly, Robin ULg; Paquet, Jean-Yves; Titeux, Nicolas et al

in Agriculture, Ecosystems & Environment (2017), 247

Over the last decade, the conversion of annual-rotation based crops or grassland areas into non-food perennial crops has been increasingly prevalent in European farming systems. This shift is associated ... [more ▼]

Over the last decade, the conversion of annual-rotation based crops or grassland areas into non-food perennial crops has been increasingly prevalent in European farming systems. This shift is associated with major changes in management practices and has created new environmental conditions and resources for wildlife. Impacts on birds have been examined for bioenergy agricultural systems, such as miscanthus plantations and short-rotation willow coppice. However, they remain largely unknown for Christmas tree plantations (CTPs) that have recently increased considerably in some European countries. We examined the extent to which CTPs alter bird species assemblages in the farmland areas of southern Belgium, where they mainly replace intensive grassland. The abundance of birds was recorded during the breeding season in randomly selected sites located in grassland and in CTP. Results show that introduction of CTP into landscapes dominated by grassland with low hedge densities locally increases bird species richness and abundance without leading to biotic homogenization. Differences in species richness and abundance between grassland and CTP decrease with increasing hedge densities. A community analysis indicates that the plantation of Christmas trees enriches the bird assemblage of intensive grassland areas. In intensive grassland with few hedges, small-size CTPs could constitute an option to increase structural heterogeneity and provide new potential breeding conditions for some farmland birds. However, questions remain about the genuine quality of the resources available in CTP and further research is needed to examine the breeding success and survival of birds that settle in this type of habitat. [less ▲]

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See detailArtificial surfaces characteristics and sediment connectivity explain muddy flood hazard in Wallonia
de Walque, Baptiste; Degré, Aurore ULg; Maugnard, Alexandre et al

in Catena (2017), 158

Over the last decades, the off-site damages caused by muddy floods have been of growing concern throughout much of Western Europe, and particularly in Wallonia (Belgium). A reliable identification of ... [more ▼]

Over the last decades, the off-site damages caused by muddy floods have been of growing concern throughout much of Western Europe, and particularly in Wallonia (Belgium). A reliable identification of locations with a high muddy flood hazard is thus a key issue in this context. The main objective of this study was therefore to build and evaluate a muddy flood hazard prediction model in order to assess the probability of occurrence of muddy floods at any specific location. A logistic regression approach was used to explain muddy flood occurrence using a database of 442 muddy flood-affected sites and an equal number of homologous non-flooded sites. Explanatory variables were related to geomorphology, land use, sediment production and sediment connectivity in the contributing area. The prediction quality of the model was then validated using an independent dataset composed of 48 pairs of flooded and non-flooded sites. The best muddy flood hazard assessment model required a total of 5 explanatory variables as inputs: the mean slope, a sediment connectivity index, as well as the proportion, spatial aggregation and proximity to the outlet of artificial surfaces. The model resulted in a prediction quality of 76% (calibration dataset) and 81% (validation dataset). Including the characteristics of artificial surfaces substantially improved the model quality (p-values from 10−11 to 10−5). All three variables related to artificial surfaces showed negative correlations with the muddy flood hazard. The proportion of cropland was not included in the final model, but this variable was strongly inversely correlated to the proportion of artificial surfaces. Besides the characteristics of artificial surfaces, sediment connectivity also showed significant explanatory power (p-value of 10−12). A positive correlation between sediment connectivity and muddy flood hazard was found. Future muddy flood hazard models should therefore include both artificial surfaces characteristics and sediment connectivity-related information. Given the good prediction quality, the developed statistical model could be used as a reliable tool to prioritize sites at risk of muddy floods in order to install mitigation measures. [less ▲]

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See detailAccuracy and performance of continuous glucose monitors in athletes
Thomas, Felicity Louise ULg; Pretty, Christopher; Signal, Matthew et al

in Biomedical Signal Processing and Control (2017)

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See detailInferring the shallow phylogeny of true salamanders (Salamandra) by multiple phylogenomic approaches.
Rodriguez, Ariel; Burgon, James D.; Lyra, Mariana et al

in Molecular Phylogenetics & Evolution (2017), 115

The rise of high-throughput sequencing techniques provides the unprecedented opportunity to analyse controversial phylogenetic relationships in great depth, but also introduces a risk of being ... [more ▼]

The rise of high-throughput sequencing techniques provides the unprecedented opportunity to analyse controversial phylogenetic relationships in great depth, but also introduces a risk of being misinterpreted by high node support values influenced by unevenly distributed missing data or unrealistic model assumptions. Here, we use three largely independent phylogenomic data sets to reconstruct the controversial phylogeny of true salamanders of the genus Salamandra, a group of amphibians providing an intriguing model to study the evolution of aposematism and viviparity. For all six species of the genus Salamandra, and two outgroup species from its sister genus Lyciasalamandra, we used RNA sequencing (RNAseq) and restriction site associated DNA sequencing (RADseq) to obtain data for: (1) 3070 nuclear protein-coding genes from RNAseq; (2) 7440 loci obtained by RADseq; and (3) full mitochondrial genomes. The RNAseq and RADseq data sets retrieved fully congruent topologies when each of them was analyzed in a concatenation approach, with high support for: (1) S. infraimmaculata being sister group to all other Salamandra species; (2) S. algira being sister to S. salamandra; (3) these two species being the sister group to a clade containing S. atra, S. corsica and S. lanzai; and (4) the alpine species S. atra and S. lanzai being sister taxa. The phylogeny inferred from the mitochondrial genome sequences differed from these results, most notably by strongly supporting a clade containing S. atra and S. corsica as sister taxa. A different placement of S. corsica was also retrieved when analysing the RNAseq and RADseq data under species tree approaches. Closer examination of gene trees derived from RNAseq revealed that only a low number of them supported each of the alternative placements of S. atra. Furthermore, gene jackknife support for the S. atra - S. lanzai node stabilized only with very large concatenated data sets. The phylogeny of true salamanders thus provides a compelling example of how classical node support metrics such as bootstrap and Bayesian posterior probability can provide high confidence values in a phylogenomic topology even if the phylogenetic signal for some nodes is spurious, highlighting the importance of complementary approaches such as gene jackknifing. Yet, the general congruence among the topologies recovered from the RNAseq and RADseq data sets increases our confidence in the results, and validates the use of phylotranscriptomic approaches for reconstructing shallow relationships among closely related taxa. We hypothesize that the evolution of Salamandra has been characterized by episodes of introgressive hybridization, which would explain the difficulties of fully reconstructing their evolutionary relationships. [less ▲]

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See detailGenetic structure of Lima bean (Phaseolus lunatus L.) landraces grown in the Mayan area
Camacho-Pérez, Luciana; Martínez-Castillo, Jaime; Mikangos-Cortés, Javier O. et al

in Genetic Resources and Crop Evolution (2017)

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See detailThree Methods to Assess Levels of Farmers’ Exposure to Pesticides in the Urban and Peri-urban Areas of Northern Benin
Lawson, Armel Joël; Akohou, Hermine; Lorge, Stéphanie ULg et al

in Tunisian Journal of Plant Protection (2017), 12(1), 91-108

Small farmers in urban and peri-urban areas of Northern Benin use pesticides without respect of hygiene rules and any personal protective equipment (PPE). Based on observation of the local practices in ... [more ▼]

Small farmers in urban and peri-urban areas of Northern Benin use pesticides without respect of hygiene rules and any personal protective equipment (PPE). Based on observation of the local practices in Djougou, Gogounou and Parakou,field trials have been carried out under similar conditions to evaluate contamination and exposure levels of farmers, using three usual sampling methods (Visual Method, Patch Method and Whole Body Method). Both Visual and Patch Methods used dye and ghost ink as tracers. In the Whole Body trials, deltamethrin (PLAN D 25 EC) was used as insecticide treatment. Deposits were observed on the protective equipment and on the collectors. Tartrazine was determined by colorimetry and deltamethrin by gas chromatography with ECD detector (GC-ECD). The examination of protective equipment (Visual Method) showed that the whole body could be potentially exposed to pesticides. Hands were contaminated during the preparation and the loading of mixture up to sprayer rinsing. The Patch Method was not perfectly able to predict the contamination pattern on the farmers’ body. The Whole Body Method results appeared to be more variable and influenced by the skill of each operator compared to the Patch Method. The contamination levels observed were rather higher than the value estimated with a theoretical model (from 368 to 2867 mg of deltamethrin at the total/body). With PPE, the average exposure reached 3.25 mg/kg bw/day. Without PPE, the potential exposure was equal to 32.52 mg/kg bw/day. Both values far exceed the AOEL of deltamethrin (0.0075 mg/kg bw/day) indicating a high risk level for the operator. The theoretical used model (UK-POEM) was unable to predict the potential exposure outcomes measured in these trials. [less ▲]

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See detailUsing nature in architecture: building a living house with mycelium and living trees
Courard, Luc ULg; Vallas, Thomas

in Frontiers of Architectural Research (2017), 6

A house that grows, build and repair itself: a house that changes at the pace of seasons, a house that uses the forces of nature and is in harmony with its environment, favoring biodiversity and natural ... [more ▼]

A house that grows, build and repair itself: a house that changes at the pace of seasons, a house that uses the forces of nature and is in harmony with its environment, favoring biodiversity and natural equilibrium, a sustainable cheap house, which does not require lot of workforce or industrial materials, a carbon-free and waste-free house, returning to nature when no longer used, that can achieve a sustainable and balanced development of mankind. Two questions: How can we use living architecture to decrease or nullify structure materials environmental costs? How can these living architecture techniques be used to comply with our current life and construction style with as little change as possible? We will then address the envelope challenges by answering a scientific - Can we find and test a new envelope material with little to no carbon impact?- and a technical - How can we use this material to create a sustainable house? - problems. These enable us to bring an answer to the main challenge in the living architecture field: demonstrating that such a house is not only feasible, but also rational and beneficial from both economic and environmental perspectives. [less ▲]

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See detailMeta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Jones, Gregory; Tromp, Gerard; Kuivaniemi, Helena et al

in Circulation Research (2017)

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See detailEvaluation of different hydrocolloids to improve dough rheological properties and bread quality of potato-wheat flour
Liu, Xingli ULg; Mu, Taihua; Yamul, Karim Diego et al

in Journal of Food Science and Technology (2017), 54(6), 15971607

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato ... [more ▼]

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato-wheat dough (the mass ratio was 1:1) rheological, fermentation properties and its bread quality. The tan δ of potato-wheat dough was significantly increased by adding HPMC compared to those of without adding hydrocolloids (from 0.337 to 0.425), which was close to wheat dough (0.531). Moreover, the dough height during fermentation process was significantly improved by adding hydrocolloids, with the order of HPMC (23.1mm) > AP (19.3mm) > AG (18.6mm) > KG (13.6mm). In addition, the potato-wheat protein bands of potato-wheat dough turned pale by adding hydrocolloids, suggesting higher molecular weight aggregation formed between proteins-hydrocolloids or proteins-proteins after fermentation process. Furthermore, HPMC significantly increased specific volume (from 1.45 to 2.22 ml/g), and hydrocolloids restrained the starch retrogradation of potato-wheat breads. [less ▲]

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See detailOffensive de la Russie contre l'autorité de la jurisprudence européenne relative au droit de vote des détenus: la Cour constitutionnelle russe et le contrôle du caractère "exécutoire" d'un arrêt de la Cour européenne des droits de l'homme
Rosoux, Géraldine ULg

in Revue Trimestrielle des Droits de l'Homme (2017)

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère ... [more ▼]

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère exécutoire d'un arrêt de la Cour européenne des droits de l'homme. Cette compétence a été exercée en ce qui concerne l'arrêt Anchugov et Gladkov c. Russie, relatif au droit de vote des détenus. [less ▲]

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See detailImpaired bone formation in ovariectomized mice reduces implant integration as indicated by longitudinal in vivo micro-computed tomography
Li, Zihui; Kuhn, Gisela; Schirmer, Michael et al

in PLoS ONE (2017), 12(9), 1-22

Although osteoporotic bone, with low bone mass and deteriorated bone architecture, provides a less favorable mechanical environment than healthy bone for implant fixation, there is no general agreement on ... [more ▼]

Although osteoporotic bone, with low bone mass and deteriorated bone architecture, provides a less favorable mechanical environment than healthy bone for implant fixation, there is no general agreement on the impact of osteoporosis on peri-implant bone (re)modeling, which is ultimately responsible for the long term stability of the bone-implant system. Here, we inserted an implant in a mouse model mimicking estrogen deficiency-induced bone loss and we monitored with longitudinal in vivo micro-computed tomography the spatio-temporal changes in bone (re)modeling and architecture, considering the separate contributions of trabecular, endocortical and periosteal surfaces. Specifically, 12 week-old C57BL/6J mice underwent OVX/SHM surgery; 9 weeks after we inserted special metal-ceramics implants into the 6th caudal vertebra and we measured bone response with in vivo micro-CT weekly for the following 6 weeks. Our results indicated that ovariectomized mice showed a reduced ability to increase the thickness of the cortical shell close to the implant because of impaired peri-implant bone formation, especially at the periosteal surface. Moreover, we observed that healthy mice had a significantly higher loss of trabecular bone far from the implant than estrogen depleted animals. Such behavior suggests that, in healthy mice, the substantial increase in peri-implant bone formation which rapidly thickened the cortex to secure the implant may raise bone resorption elsewhere and, specifically, in the trabecular network of the same bone but far from the implant. Considering the already deteriorated bone structure of estrogen depleted mice, further bone loss seemed to be hindered. The obtained knowledge on the dynamic response of diseased bone following implant insertion should provide useful guidelines to develop advanced treatments for osteoporotic fracture fixation based on local and selective manipulation of bone turnover in the peri-implant region. [less ▲]

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See detailUse of the potential probiotic strain Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers.
Saint-Cyr, Manuel Jimmy; Haddad, Nabila; Taminiau, Bernard ULg et al

in International Journal of Food Microbiology (2017)

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler ... [more ▼]

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler chicken will lower the risk to consumers. The aim of this project was to evaluate the ability of Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers and to investigate the mechanisms that could be involved. Thirty broilers artificially contaminated with C. jejuni were treated by oral gavage with MRS broth or a bacterial suspension (107CFU) of Lb. salivarius SMXD51 (SMXD51) in MRS broth. At 14 and 35days of age, Campylobacter and Lb. salivarius loads were assessed in cecal contents. The impact of the treatment on the avian gut microbiota at day 35 was also evaluated. At day 14, the comparison between the control and treated groups showed a significant reduction (P<0.05) of 0.82 log. After 35days, a significant reduction (P<0.001) of 2.81 log in Campylobacter loads was observed and 73% of chickens treated with the culture exhibited Campylobacter loads below 7log10CFU/g. Taxonomic analysis revealed that SMXD51 treatment induced significant changes (P<0.05) in a limited number of bacterial genera of the avian gut microbiota and partially limited the impact of Campylobacter on Anaerotruncus sp. decrease and Subdoligranulum sp. increase. Thus, SMXD51 exhibits an anti-Campylobacter activity in vivo and can partially prevent the impact of Campylobacter on the avian gut microbiota. [less ▲]

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See detailElectronic states and valley-orbit coupling in linear and planar molecules formed by coupled P donors in silicon
Klymenko, M. V.; Rogge, S.; Remacle, Françoise ULg

in Physical Review. B : Condensed Matter (2017), 95(20), 205301

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See detailChemical profiling of the major components in natural waxes to elucidate their role in liquid oil structuring
Doan, Chi Diem; To, Chak Ming; De Vrieze, Mike et al

in Food Chemistry (2017), 214

Elucidating the composition of waxes is of utmost importance to explain their behavior in liquid oil structuring. The chemical components (hydrocarbons – HCs, free fatty acids – FFAs, free fatty alcohols ... [more ▼]

Elucidating the composition of waxes is of utmost importance to explain their behavior in liquid oil structuring. The chemical components (hydrocarbons – HCs, free fatty acids – FFAs, free fatty alcohols – FALs and wax esters – WEs) of natural waxes were analyzed using HPLC–ELSD and GC–MS followed by evaluation of their oil structuring properties. The gel strength, including the average storage modulus and oscillation yield stress, displayed a negative correlation with FALs and a positive correlation with HCs, FFAs and WEs. The components dictating the gel strength are HCs, FFAs and WEs in a descending order of importance. The consistency of the oleogels increased with the increasing amount of FFAs and HCs and the decreasing amount of WEs and FALs. The presence of more WEs results in a strong but brittle gel with a high initial flow yield stress. We believe these results might be useful in selecting the right waxes to combine in certain fat-based food products. [less ▲]

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See detailThe effect of feedback on children’s metacognitive judgments: a heuristic account
Geurten, Marie ULg; Meulemans, Thierry ULg

in Journal of Cognitive Psychology (2017), 29(2), 184-201

In three experiments, we investigated whether the feedback effect on the accuracy of children’s metacognitive judgments results from an improvement in monitoring processes or the use of the Anchoring-and ... [more ▼]

In three experiments, we investigated whether the feedback effect on the accuracy of children’s metacognitive judgments results from an improvement in monitoring processes or the use of the Anchoring-and-Adjustment heuristic. Experiment 1 revealed that adding feedback increased the accuracy of young children’s (aged 4, 6, and 8 years) memory prediction. In Experiment 2, the influence of an external anchor on children’s metacognitive judgment was established. Finally, in Experiment 3, two memory tasks that differed in terms of difficulty were administered. Participants were randomly assigned to an anchoring (high/low/no anchor) and a feedback (feedback/no feedback) condition. Results demonstrated that children in the feedback condition adjusted their predictions toward the feedback, regardless of the task’s difficulty. These findings are consistent with the hypothesis that external information provided by feedback is used as an anchor for judgment. This interpretation is strengthened by the correlation found between the two scores computed to assess participants’ susceptibility to anchoring and feedback effects, which indicates that children who are more sensitive to the anchoring effect are also more sensitive to the feedback effect. [less ▲]

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See detailIconic virtues of diagrams. Peirce on ampliative reasoning
Leclercq, Bruno ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

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See detailNuclear Motion Driven Ultrafast Photodissociative Charge Transfer of the PENNA Cation: An Experimental and Computational Study
Sun, Shoutian; Mignolet, Benoît ULg; Fan, lin et al

in Journal of Physical Chemistry A (2017), 121(7), 1442

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See detailEquine Atypical Myopathy in the UK: Epidemiological characteristics of cases reported from 2011 to 2015 and factors associated with survival
Gonzalez-Medina, S.; Ireland, J. L.; Piercy, R. J. et al

in Equine Veterinary Journal (2017)

BACKGROUND: Equine atypical myopathy (AM) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from Acer pseudoplatanus tree. Despite the wide distribution of ... [more ▼]

BACKGROUND: Equine atypical myopathy (AM) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from Acer pseudoplatanus tree. Despite the wide distribution of this tree species in the UK, the number of cases reported annually varies, and there has been an apparent increase in prevalence in recent years. Although AM was first recognised in the UK, epidemiological studies have never been conducted focused solely on this country. OBJECTIVES: To describe the spatiotemporal distribution, presentation, treatment and outcome of AM cases reported in the UK. STUDY DESIGN: Retrospective case series. METHODS: British AM cases reported to the atypical myopathy alert website, between 2011 and 2015 were included (n = 224). Data were obtained via standardised epidemiological questionnaires from owners and veterinarians. Factors associated with survival were assessed using logistic regression. RESULTS: Most cases reported were from England (87.9%). Survival was 38.6% (n = 73/189). Clinical factors associated with reduced odds of survival included, hypothermia (odds ratio (OR) 0.18; CI 0.06-0.57; p = 0.01), bladder distension (OR 0.11; CI 0.02-0.59; p = 0.01), tachycardia (OR 0.97; CI 0.94-0.99; p = 0.04) and serum creatine kinase activity >100,000 IU/L (OR 0.17; CI 0.04-0.68; p = 0.01) in the univariable analysis as well as recumbency. The latter was the only sign retained in multivariable analysis (OR = 0.19; CI 0.06-0.62; p = 0.006). Administration of vitamins during the disease was associated with survival (OR 3.75; CI 1.21-11.57; p = 0.02). MAIN LIMITATIONS: Reporting cases to the atypical myopathy alert group is voluntary; therefore, under-reporting will result in underestimation of AM cases; furthermore, direct owner-reporting could have introduced misdiagnosis bias. CONCLUSION: Some areas of the UK reported AM cases more commonly. Clinical signs such as recumbency, rectal temperature, distended bladder and serum CK activity might be useful prognostic indicators though should be considered in the context of the clinical picture. Treatment with vitamins increases survival. This article is protected by copyright. All rights reserved. [less ▲]

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See detailComprehensive multi-modality imaging approach in arrhythmogenic cardiomyoapthy : an expert consensus document of the European Association of Cardiovascular Imaging
Haugaa, KH; Basso, C; Badano, LP et al

in European Heart Journal - Cardiovascular Imaging (2017)

Arrhythmogenic cardiomyopathy (AC) is a progressive disease with high risk of life-threatening ventricular arrhythmias. A genetic mutation is found in up to 50-60% of probands, mostly affecting desmosomal ... [more ▼]

Arrhythmogenic cardiomyopathy (AC) is a progressive disease with high risk of life-threatening ventricular arrhythmias. A genetic mutation is found in up to 50-60% of probands, mostly affecting desmosomal genes. Diagnosis of AC is made by a combination of data from different modalities including imaging, electrocardiogram, Holter monitoring, family history, genetic testing, and tissue properties. Being a progressive cardiomyopathy, repeated cardiac imaging is needed in AC patients. Repeated imaging is important also for risk assessment of ventricular arrhythmias. This expert consensus document gives clinical recommendations for how to use multi-modality imaging in the different aspects of AC disease, including diagnosis, family screening, follow-up, risk assessment, and differential diagnosis. [less ▲]

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See detailThe miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development.
Van Den Ackerveken, Priscilla ULg; Mounier, Anaïs ULg; Huyghe, Aurelia et al

in Cell Death & Differentiation (2017)

MicroRNAs are important regulators of gene expression and are involved in cellular processes such as proliferation or differentiation, particularly during development of numerous organs including the ... [more ▼]

MicroRNAs are important regulators of gene expression and are involved in cellular processes such as proliferation or differentiation, particularly during development of numerous organs including the inner ear. However, it remains unknown if miRNAs are required during the earliest stages of otocyst and cochlear duct development. Here, we report that a conditional loss of Dicer expression in the otocyst impairs the early development of the inner ear as a result of the accumulation of DNA damage that trigger p53-mediated apoptosis. Moreover, cochlear progenitors in the prosensory domain do not exit the cell cycle. Our unbiased approach identified ItgA3 as a target of miR-183, which are both enriched in the otic vesicle. We observed that the repression of integrin alpha 3 by miR-183 controls cell proliferation in the developing cochlea. Collectively, our results reveal that Dicer and miRNAs play essential roles in the regulation of early inner ear development.Cell Death and Differentiation advance online publication, 4 August 2017; doi:10.1038/cdd.2017.127. [less ▲]

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See detailSubsidence related to groundwater pumping for breweries in Merchtem area (Belgium), highlighted by Persistent Scaterrer Interferometry
Declercq, Pierre-Yves; Gerard, Pierre; Pirard, Eric ULg et al

in International Journal of Applied Earth Observation and Geoinformation (2017), 63

ERS, ENVISAT and TerraSAR-X Synthetic Aperture Radar scenes covering the time span 1992–2014 were processed using a Persistent Scatterer technique to study the ground movements in Merchtem (25 km NW of ... [more ▼]

ERS, ENVISAT and TerraSAR-X Synthetic Aperture Radar scenes covering the time span 1992–2014 were processed using a Persistent Scatterer technique to study the ground movements in Merchtem (25 km NW of Brussels, Belgium). The processed datasets, covering three consecutive time intervals, reveal that the investigated area is affected by a global subsidence trend related to the extraction of groundwater in the deeper Cambro-Silurian aquifer. Through time the subsidence pattern is reduced and replaced by an uplift related to the rising water table attested by piezometers located in this aquifer. The subsidence is finally reduced to a zone where currently three breweries are very active and pump groundwater in the Ledo-Paniselian aquifer and in the Cambro-Silurian for process water for the production. [less ▲]

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See detailAu coeur de la protection "multi-niveaux" et du dialogue juridictionnel : la "dématérialisation" des droits fondamentaux comme clé de lecture du raisonnement actuel dans le domaine des droits fondamentaux
Rosoux, Géraldine ULg

in Fundamentos (2017), 9

L'article examine les différents raisonnements suivis par la Cour européenne des droits de l'homme, la Cour de justice de l'Union européenne et le juge constitutionnel belge, pour faire face à la ... [more ▼]

L'article examine les différents raisonnements suivis par la Cour européenne des droits de l'homme, la Cour de justice de l'Union européenne et le juge constitutionnel belge, pour faire face à la protection "multi-niveaux" des droits fondamentaux. [less ▲]

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See detailA new electron-ion coincidence 3D momentum-imaging method and its application in probing strong field dynamics of 2-phenylethyl-N, N-dimethylamine
Fan, Lin; Lee, Suk Kyoung; Tu, Yi-Jung et al

in Journal of Chemical Physics (2017), 147

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See detailEl cine en el género chico (1897-1936)
Ceballos Viro, Alvaro ULg

in Hecho Teatral (2017), 17

This paper examines a corpus of 39 short plays of the Spanish musical theater that deal with the cinema. The dialogue between the so-called género chico and the new medium cinema dates back to 1897 and ... [more ▼]

This paper examines a corpus of 39 short plays of the Spanish musical theater that deal with the cinema. The dialogue between the so-called género chico and the new medium cinema dates back to 1897 and adopts, in a roughly consecutive manner, five different modes: the re-staging of cinema’s first screenings and its spaces; make-believe cinema projections; the inclusion of projections as part of the play; the adaption of cinematic themes and plots, and, finally, the onstage appearances of characters the silver screen had made popular. The paper thus demonstrates that the first Spanish writers who showed interest in the cinema were not avant-garde poets or the essayists gravitating around Ortega y Gasset, and reflects on the historiographical cliché stating that structural or topical imitation of cinema is a sign of modernity. [less ▲]

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See detailIncreased expression of bacterial amoA during an N2O emission peak in an agricultural field
Theodorakopoulos, Nicolas ULg; Lognoul, Margaux ULg; Degrune, Florine ULg et al

in Agriculture, Ecosystems & Environment (2017), 236

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak ... [more ▼]

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak on a maize crop after a natural rainfall. The peak occurred rapidly after the rainfall began. Spatial and temporal variability in N2O emission was observed between chambers. An analysis of N-cycle gene transcript levels revealed an increase in bacterial amoA gene transcripts (but not in archaeal amoA transcripts), correlating strongly with N2O emission. This suggests the involvement of nitrification enzymes, despite a high water-filled pore space (80%). Reverse transcription of bacterial 16S rRNA followed by partial sequencing of the resulting cDNAs revealed few rainfall-induced changes in the potentially active bacterial community, and notably no significant change in the relative abundance of 16S rRNAs from the nitrifier genus Nitrosospira. Expression of the amoA gene appears as a possible proxy for monitoring the N2O emission peak. To our knowledge, this is the first experiment to evaluate the expression of N-cycle genes during an N2O emission peak on an agricultural field. [less ▲]

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See detailThe Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission.
Zeippen, Caroline ULg; Javaux, Justine; Xiao, Xue ULg et al

in Journal of Virology (2017), 91(13),

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a ... [more ▼]

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and in vitro, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection but is poorly released from vaginal epithelial cells and fails to pass from the female to the male genital tract during sexual contact. Thus, we show that the regulation of virion binding is a key component of spontaneous gammaherpesvirus transmission.IMPORTANCE Gammaherpesviruses are responsible for many important diseases in both animals and humans. Some important aspects of their life cycle are still poorly understood. Key among these is viral transmission. Here we show that the major envelope glycoprotein of murid herpesvirus 4 functions not in entry or dissemination but in virion release to allow sexual transmission to new hosts. [less ▲]

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See detailLes « cavaliers budgétaires » sont-ils éphémères ? Une controverse qui perdure (note sous C.C., arrêt n° 58/2016 du 28 avril 2016)
Miny, Xavier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (3), 110-117

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions ... [more ▼]

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions de budget et de cavalier budgétaire, ainsi que sur la durée de vie de ce genre controversé de dispositions et sur la compétence d’avis du Conseil d’État en la matière. Confrontée pour la première fois à certaines problématiques qu’engendrent les cavaliers budgétaires, la Cour constitutionnelle s’est néanmoins refusée à trancher l’ensemble des débats. [less ▲]

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See detailReliability of muscle strength measures obtained with a hand-held dynamometer in an elderly population.
Buckinx, Fanny ULg; Croisier, Jean-Louis ULg; Reginster, Jean-Yves ULg et al

in Clinical Physiology & Functional Imaging (2017), 37(3), 332-40

BACKGROUND: The objective of this study was to assess the reliability of a hand-held dynamometer for isometric strength measurements among nursing home residents. METHODS: The isometric muscle strength of ... [more ▼]

BACKGROUND: The objective of this study was to assess the reliability of a hand-held dynamometer for isometric strength measurements among nursing home residents. METHODS: The isometric muscle strength of nursing home residents was assessed for eight different muscle groups, using a hand-held dynamometer, the MicroFET2 device. Strength measurements were performed at baseline and after 4 days by the same operator and after 8 days by a second operator. Intraclass coefficients (ICC) were computed to assess the relative reliability, whereas the minimal detectable change (MDC%) was calculated to assess the absolute reliability of the test-retest of the MicroFET2 used by one single operator or by two different ones. RESULTS: Thirty nursing home residents (75.0 +/- 11.2 years, 50% of women) were enrolled in this study. ICC of the test-retest with one single operator ranged from 0.60 (0.37-0.83) for the ankle extensors to 0.85 (0.74-0.95) for the elbow flexors. When considering the test-retest with two different operators, the ICC values ranged from 0.62 (0.41-0.84) for the ankle extensors to 0.87 (0.79-0.96) for the elbow extensors. For the absolute reliability, MDC% varies from 27.64 (elbow flexors) to 81.97 (ankle extensors) when performed in intra-observer. In interobserver condition, MDC%, respectively, varies from 24.38 (elbow extensors) 67.59 (ankle extensors). CONCLUSION: Using standardized protocol and standardized instructions to patients, a high relative and moderate absolute reliability was observed for all but ankle muscle groups, making this hand-held dynamometer a potential tool for research in the elderly population. [less ▲]

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See detailA robust statistical approach to select adequate error distributions for financial returns
Hambuckers, julien ULg; Heuchenne, Cédric ULg

in Journal of Applied Statistics (2017), 44(1), 137-161

In this article, we propose a robust statistical approach to select an appropriate error distribution, in a classical multiplicative heteroscedastic model. In a first step, unlike to the traditional ... [more ▼]

In this article, we propose a robust statistical approach to select an appropriate error distribution, in a classical multiplicative heteroscedastic model. In a first step, unlike to the traditional approach, we don't use any GARCH-type estimation of the conditional variance. Instead, we propose to use a recently developed nonparametric procedure (Mercurio and Spokoiny, 2004): the Local Adaptive Volatility Estimation (LAVE). The motivation for using this method is to avoid a possible model misspecification for the conditional variance. In a second step, we suggest a set of estimation and model selection procedures (Berk-Jones tests, kernel density-based selection, censored likelihood score, coverage probability) based on the so-obtained residuals. These methods enable to assess the global fit of a set of distributions as well as to focus on their behavior in the tails, giving us the capacity to map the strengths and weaknesses of the candidate distributions. A bootstrap procedure is provided to compute the rejection regions in this semiparametric context. Finally, we illustrate our methodology throughout a small simulation study and an application on three time series of daily returns (UBS stock returns, BOVESPA returns and EUR/USD exchange rates) [less ▲]

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See detailExercise Testing and Stress Imaging in Mitral Valve Disease.
Voilliot, Damien; Lancellotti, Patrizio ULg

in Current Treatment Options in Cardiovascular Medicine (2017), 19(3), 17

OPINION STATEMENT: Mitral valve disease represented by mitral stenosis and mitral regurgitation is the second most frequent valvulopathy. Mitral stenosis leads to an increased left atrial pressure whereas ... [more ▼]

OPINION STATEMENT: Mitral valve disease represented by mitral stenosis and mitral regurgitation is the second most frequent valvulopathy. Mitral stenosis leads to an increased left atrial pressure whereas mitral regurgitation leads to an increased left atrial pressure associated with a volume overload. Secondary to an upstream transmission of this overpressure, both mitral stenosis and regurgitation lead to pulmonary hypertension and right heart failure. In addition, mitral regurgitation also leads to left ventricular dilatation and dysfunction with left heart failure. Depending on the anatomy of the valvular and subvalvular apparatus, valve repair (percutaneous mitral commissurotomy for mitral stenosis and valvuloplasty for mitral regurgitation) might be possible. If the anatomy is not favorable, valve replacement by mechanical or biological prosthesis is indicated. Most of the intervention indications are based on clinical symptoms and resting transthoracic echocardiography. Outcomes of patients operated based upon resting echo abnormalities might however not be optimal. Therefore early intervention might be beneficial based upon abnormal exercise testing, which has been demonstrated to more sensitive to identify high-risk patients. In this last decade, especially exercise echocardiography has been found to be a crucial tool in the management of patients with mitral valve disease. [less ▲]

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See detailExposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Sabatel, Catherine ULg; Radermecker, Coraline ULg; Fievez, Laurence ULg et al

in Immunity (2017), 46(3), 457-473

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major ... [more ▼]

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow. Using a mouse model of allergic airway inflammation, we found that adoptive transfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. IM-mediated protection was dependent on IL-10, given that Il10-/- CpG-induced IMs lacked regulatory effects. Thus, the expansion of regulatory lung IMs upon exposure to CpG might underlie the reduced risk of asthma development associated with a microbe-rich environment. [less ▲]

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