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See detailDiscussion of "Two-dimensional depth-averaged finite volume model for unsteady turbulent flows"
Erpicum, Sébastien ULg; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Research (2014), 52(1), 148-150

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See detailThinking out of the box - New approaches to controlling GVHD
Baron, Frédéric ULg; Humblet-Baron, Stéphanie; Ehx, Grégory ULg et al

in Current Hematologic Malignancy Reports (2014), 9

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD ... [more ▼]

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to bebased on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatmentsstill relies on high-dose corticosteroids. Further, no second line treatment has emerged thus far in acute or chronic GVHD patients who failed on corticosteroids. After briefly reviewing current standards of GVHD prevention and treatment, this article will discuss recent approaches that might change GVHD prophylaxis / treatment in the next decades, with a special focus on recently developed immunoregulatory strategies based on infusion of mesenchymal stromal or regulatory T-cells, or on injection of lowdose interleukin-2. [less ▲]

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See detailCD36: linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis
Oury, Cécile ULg

in Cellular & Molecular Immunology (2014), 11

Uptake of the atherogenic lipid mediator oxLDL by CD36 results in the formation of intracellular cholesterol crystals that caused lyso¬somal destabilization and NLRP3 activation. oxLDL not only primes ... [more ▼]

Uptake of the atherogenic lipid mediator oxLDL by CD36 results in the formation of intracellular cholesterol crystals that caused lyso¬somal destabilization and NLRP3 activation. oxLDL not only primes, via a NF-κB-dependent pathway, but also activates NLRP3. CD36-mediated inflammasome activation provides an early pathogenic pathway that links cholesterol accumulation to the chronic inflammatory process of atherosclerosis. During atherogenesis, activated or injured endothelial cells, leucocytes and platelets release ATP that acts in a paracrine manner to transduce sterile inflammatory signals. Among these signals, P2X7 receptors mediate K+ efflux leading to NLRP3 activation. Since ATP assembles ASC complexes in oxLDL-treated macrophages, P2X7 receptors and CD36 may cooperate in vivo to activate NLRP3 inflammasome, contributing to plaque formation. Besides macrophages, CD36 is expressed on platelets where it mediates oxLDL-dependent platelet activation and potentially further IL-1β release. P2X7 receptors contributes to protein disulfide isomerase (PDI) tissue factor-dependent thrombosis. Consequently, both CD36 and P2X7 receptors may be involved in atherothrombosis upon plaque rupture. [less ▲]

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See detailGynecologic and obstetric impact of the Ehlers-Danlos syndrome: clues from scrutinizing dermal ultrastructural alterations.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Gynecology (2014), 2(1),

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective ... [more ▼]

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissue fragility. Each EDS type corresponds to a multisystemic disorder with widespread implications. Physicians evoke the EDS diagnosis in presence of some typical cutaneous signs, such as atrophic scars and frequent hematomas. Methods: To revisit the transmission electron microscopy support from skin biopsies when screening EDS in gynecology-obstetrics. Results: EDS women commonly suffer from a series of gynecologic and obstetric disorders. Dermal ultrastructural changes are keynote features suggesting some EDS types. Conclusion: Gene mutations are mostly identified in the classic and vascular EDS types, but only in sporadic cases of the hypermobile EDS type which apparently represents the most frequent type. Dermal ultrastructural changes represent relevant diagnostic clues for the practitioner. Preconception counseling about possible complications is welcome. Management requires precise diagnosis of the EDS type. [less ▲]

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See detailL'économie rhétorique du Résumé
Provenzano, François ULg

in Janus. Quaderni del circolo glossematico (2014), 13

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See detailPEGylation of antibody fragments greatly increases their local residence time following delivery to the respiratory tract.
Koussoroplis, Salome Juliette; Paulissen, Geneviève ULg; Tyteca, Donatienne et al

in Journal of Controlled Release (2014), sous presse

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The ... [more ▼]

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The aim of this research was to study the effects of the PEGylation of antibody fragments on their local residence time after administration to the respiratory tract. We demonstrate that the conjugation of a two-armed 40-kDa polyethylene glycol (PEG) chain to anti-interleukin-17A (IL-17A) F(ab')2 and anti-IL-13 Fab' greatly prolonged the presence of these fragments within the lungs of mice. The content of PEGylated antibody fragments within the lungs plateaued up to 4hours post-delivery, whereas clearance of unconjugated proteins started immediately after administration. Forty-eight hours post-delivery, F(ab')2 and Fab' content in the lungs had decreased to 10 and 14 % of the dose initially deposited, respectively. However, this value was 40 % for both PEG40-F(ab')2 and PEG40-Fab'. The prolonged pulmonary residency of the anti-IL-17A PEG40-F(ab')2 translated into an improved efficacy in reducing lung inflammation in a murine model of house dust mite-induced lung inflammation. We demonstrate that PEGylated proteins were principally retained within the lung lumen rather than the nasal cavities or lung parenchyma. In addition, we report that PEG increased pulmonary retention of antibody fragments through mucoadhesion and escape from alveolar macrophages rather than increased hydrodynamic size or improved enzymatic stability. The PEGylation of proteins might find broad application in the local delivery of therapeutic proteins to diseased airways. [less ▲]

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See detailA review of the microbiological hazards of raw milk from animal species other than cows
Verraes, Claire; Claeys, Wendy; Cardoen, Sabine et al

in International Dairy Journal (2014), sous presse

This review concentrates on information concerning the microbiological hazards that can be present in raw milk from animal species other than cows. Total bacterial counts of raw milk are described for ... [more ▼]

This review concentrates on information concerning the microbiological hazards that can be present in raw milk from animal species other than cows. Total bacterial counts of raw milk are described for several animal species, indicating the quality of the milk, then frequencies of occurrence of several human pathogenic microorganisms are considered and, finally, human cases of illness and outbreaks due to the consumption of raw milk from non-bovine species are covered. Only raw milk from goats and camels has so far been reported to be associated with outbreaks. Raw milk from horse and donkey may have a higher microbiological quality than raw milk from other animal species, although human pathogenic strains of Streptococcus are considered as a microbiological hazard for such milk. For raw milk from other animal species, the main microbiological hazards seem to be human pathogenic Escherichia coli, Campylobacter spp., tick-borne encephalitis virus and Brucella spp. [less ▲]

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See detailDynamic seasonal nitrogen cycling in response to anthropogenic N loading in a tropical catchment, Athi–Galana–Sabaki River, Kenya
Marwick, T. R.; Tamooh, F.; Ogwoka, B. et al

in Biogeosciences (2014), 11(2), 443--460

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See detailAvaliação da Qualidade de Vida Infantil: O Inventário Sistémico de Qualidade de Vida para Crianças
Fonseca, Marta; Missotten, Pierre ULg; Etienne, Anne-Marie ULg et al

in Psicologia, Reflexão e Crítica = Psychology, Reflection and Criticism (2014), 27(2),

Introduction: Children’s quality of life evaluation has specific methodological aspects. Objective: To examine the psychometric properties of the Portuguese version of the Child Quality of Life Systemic ... [more ▼]

Introduction: Children’s quality of life evaluation has specific methodological aspects. Objective: To examine the psychometric properties of the Portuguese version of the Child Quality of Life Systemic Inventory (CQLSI), which is based on an innovative conceptual and methodological approach to quality of life self-assessment, namely by being interactive and playful, having a psychometry which operates several scores and allowing an analysis of each domain of life. Methods: 120 Portuguese children, from 8 to 12 years old. Results: Internal consistency of the four scores of the CQLSI (State, Goal, Rank and Gap) is satisfactory; all scores have their own specificity. Data show convergent validity. On the other hand, no satisfactory factorial structure was found. Conclusion: Feasibility and psychometric adequacy of the CQLSI Portuguese version seems demonstrated. [less ▲]

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See detailJupiter's Magnetotail
Krupp, Norbert; Kronberg, Elena; Radioti, Aikaterini ULg

in AGU Monograph (2014)

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See detailPrix prédateurs : La Cour d’appel de Paris saisit l’Autorité de la Concurrence d’une demande d’avis pour apprécier le caractère prédateur d’un prix nul
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2014), 1

CA Paris, 20 novembre 2013, Google France et Google c/ Bottin Cartographe

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See detailExtinction de l'hypothèque pour toutes créances futures par suite de la cessation de la relation bancaire ?
Biquet, Christine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2014), (5), 223-224

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See detailUrtica jacta est : quelques mots de la quatrième édition du concours facultaire de dissertation et d'éloquence
Deprez, Christophe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 1

Ce bref compte rendu évoque la quatrième édition du concours de dissertation et d'éloquence organisé par le personnel scientifique de la Faculté de droit, de science politique et de criminologie de l ... [more ▼]

Ce bref compte rendu évoque la quatrième édition du concours de dissertation et d'éloquence organisé par le personnel scientifique de la Faculté de droit, de science politique et de criminologie de l'Universté de Liège (2013-2014). [less ▲]

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See detailSocial Security and Family Support
Leroux, Marie Louise; Pestieau, Pierre ULg

in Canadian Journal of Economics (2014), 47(1), 115-143

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See detailMesozoic marine reptile palaeobiogeography in response to drifting plates
Bardet, Nathalie; Falconnet, Jocelyn; Fischer, Valentin ULg et al

in Gondwana Research (2014)

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically ... [more ▼]

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically, and most were the largest top-predators of the marine ecosystems of their time. The main groups were Ichthyosauria, Sauropterygia, Thalattosauria, and several lineages of Testudinata, Crocodyliformes, Rhynchocephalia and Squamata. Here we show that the palaeobiogeographical distribution of these marine reptiles closely followed the break-up of the supercontinent Pangaea and that they globally used the main marine corridors created by this break-up to disperse. Most Mesozoic marine reptile clades exhibit a cosmopolitan, or at least pandemic, distribution very early in their evolutionary history. The acquisition of morphological adaptations to a fully aquatic life, combined to special thermophysiological characteristics, are probably responsible for these animals to become efficient long-distance open-marine cruisers. Generally, Early Triassic taxa were near-shore animals mainly linked to the Tethys or Panthalassa coastlines. By the end of the Triassic and during the Jurassic, the break-up of Pangaea resulted in the formation of large marine corridors connecting the Tethys to the North Atlantic and Pacific realms, a trend increasing on during the Cretaceous with the expansion of the Atlantic Ocean and the break-up of the southern Gondwana, allowing open-sea marine reptiles to spread out over large distances. However, if large faunal interchanges were possible at a global scale following a dispersal model, some provinces, such as the Mediterranean Tethys, were characterized by a peculiar faunal identity, illustrating an absence of migration with time despite the apparent lack of barriers. So, if Continental Drift enabled global circulations and faunal interchanges via dispersals among Mesozoic marine reptiles, others parameters, such as ecological and biological constraints, probably also played a role in the local endemic distribution of some of these marine groups, as they do today. [less ▲]

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See detailDorsomedial prefrontal metabolism and unawareness of current characteristics of personality traits in Alzheimer’s disease
Jedidi, Haroun ULg; Feyers, Dorothée ULg; Collette, Fabienne ULg et al

in Social Cognitive and Affective Neuroscience (2014)

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while ... [more ▼]

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while unawareness of current characteristics of personality traits has rarely been considered. We used a well-established questionnaire-based method in a group of 37 AD patients and in healthy controls to probe self- and hetero-evaluation of patients’ personality and we calculated differential scores between each participant’s and his/her relative’s judgments. A brain-behavior correlation was performed using FDG-PET images. The behavioral data showed that AD patients presented with anosognosia for current characteristics of their personality and their anosognosia was primarily explained by impaired third perspective taking. The brain-behavior correlation analysis revealed a negative relationship between anosognosia for current characteristics of personality and dorsomedial prefrontal cortex (dMPFC) activity. Behavioral and neuroimaging data are consistent with the view that impairment of different functions subserved by the dMPFC (self-evaluation, inferences regarding complex enduring dispositions of self and others, confrontation of perspectives in interpersonal scripts) plays a role in anosognosia for current characteristics of personality in AD patients. [less ▲]

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See detailIn Vitro and In Vivo Characterization of Plant Growth Promoting Bacillus Strains Isolated from Extreme Environments of Eastern Algeria.
Ait-Kaki, Asma; Kacem-Chaouche, Noreddine; Ongena, Marc ULg et al

in Applied biochemistry and biotechnology (2014), 172

This report is to our knowledge the first to study plant growth promotion and biocontrol characteristics of Bacillus isolates from extreme environments of Eastern Algeria. Seven isolates of 14 (50 %) were ... [more ▼]

This report is to our knowledge the first to study plant growth promotion and biocontrol characteristics of Bacillus isolates from extreme environments of Eastern Algeria. Seven isolates of 14 (50 %) were screened for their ability to inhibit growth of some phytopathogenic fungi on PDA and some roots exudates. The bacteria identification based on 16S r-RNA and gyrase-A gene sequence analysis showed that 71 % of the screened isolates belonged to Bacillus amyloliquefaciens and the rest were closely related to B. atrophaeus and B. mojavensis. Most of them had high spore yields (22 x 108-27 x 108 spores/ml). They produced protease and cellulase cell wall-degrading enzymes while the chitinase activity was only observed in the B. atrophaeus (6SEL). A wide variety of lipopeptides homologous was detected by liquid chromatography-electrospray ionization-mass spectrometry analysis. Interestingly, some additional peaks with new masses were characterized, which may correspond to new fengycin classes. The isolates produced siderophores and indole-3- acetic acid phytohormone. The greenhouse experiment using a naturally infested soil with Sclerotonia sclerotiorum showed that the B. atrophaeus (6SEL) significantly increased the size of the chickpea plants and reduced the stem rot disease (P < 0.05). These results suggest that these isolates may be used further as bio-inoculants to improve crop systems. [less ▲]

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See detailCarotid artery and aortic stiffness evaluation in aortic stenosis.
Weisz, Sara Hana; Magne, Julien ULg; Dulgheru, Raluca et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2014), 27(4), 385-92

BACKGROUND: In aortic stenosis (AS), the combination of risk factors can progressively lead to an increased arterial rigidity, which can be evaluated by the carotid artery and aortic stiffness (beta index ... [more ▼]

BACKGROUND: In aortic stenosis (AS), the combination of risk factors can progressively lead to an increased arterial rigidity, which can be evaluated by the carotid artery and aortic stiffness (beta index). The aim of this study was to investigate the relationship between carotid and aortic beta index, left ventricular (LV) function, plasma brain natriuretic peptide (BNP) level, and symptoms in patients with AS. METHODS: Comprehensive echocardiography including Doppler tissue imaging of the mitral annulus was performed in 53 patients with AS (aortic valve area < 1.2 cm(2)) and preserved LV ejection fractions (>/=50%). Carotid beta index was automatically derived from ultrasound wall tracking of the right carotid artery. The mitral E/e' ratio was used to estimate LV filling pressures. RESULTS: Carotid beta index was higher in women than in men and was significantly correlated with age (P < .0001), diastolic arterial pressure (P = .046), pulse pressure (P = .006), and systemic arterial compliance (P = .001). Interestingly, carotid beta index was significantly correlated with E/e' ratio (P < .0001) and plasma BNP level (P = .011). In multivariate regression analysis, carotid beta index was an independent predictor of E/e' ratio (P < .0001) and of BNP level (P = .02). Moreover, carotid beta index was significantly higher in symptomatic patients (P = .009). Aortic beta index was significantly correlated with carotid beta index (P < .0001), E/e' ratio (P = .004), and BNP (P < .001) and was significantly higher in symptomatic patients (P = .037). CONCLUSIONS: In patients with moderate to severe AS and preserved LV ejection fractions, the presence of increased carotid artery and aortic stiffness, assessed using carotid and aortic beta index, is independently associated with elevated LV filling pressures, BNP level, and symptoms. [less ▲]

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See detailSpatial Planning as a driver of change in mobility and residential energy consumption
Dujardin, Sébastien; Marique, Anne-Françoise ULg; Teller, Jacques ULg

in Energy & Buildings (2014), 68

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning ... [more ▼]

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning decisions upon energy consumption in both residential building stock and home-to-work commuting. The analysis has been conducted on a regional scale (16,844 km2) and includes urban, peri-urban and rural settlements. Those settlements that perform well in mobility also appear to perform well in terms of building energy consumption. Even though this is not generally the case, it further reveals that some rural settlements characterized by low density show good performance in terms of energy efficiency. This permits a much more progressive approach in terms of spatial planning, whereby compact cities may be viewed as part of the solution, albeit not the whole solution. [less ▲]

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See detailBrominated and phosphorus flame retardants in White-tailed Eagle Haliaeetus albicilla nestlings: Bioaccumulation and associations with dietary proxies (δ13C, δ15N and δ34S)
Eulaers, Igor; Jaspers, Veerle; Halley, Duncan et al

in Science of the Total Environment (2014), 478

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation ... [more ▼]

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation potential, and toxicity have been made. We investigated the accumulation of BFRs and PFRs, and their associations with dietary proxies (δ13C, δ15N and δ34S), in plasma and feathers of White-tailed Eagle Haliaeetus albicilla nestlings from Trøndelag, Norway. In addition to accumulation of a wide range of polybrominated diphenyl ether (PBDE) congeners in both plasma and feathers, all non-PBDE BFRs and PFRs could be measured in feathers, while in plasma only two of six PFRs, i.e. tris-(2-chloroisopropyl) phosphate (TCIPP) and tris-(2,3-dichloropropyl) phosphate (TDCPP) were detected. PFR concentrations in feathers (0.95-3,000 ng g-1) were much higher than selected organochlorines (OCs), such as polychlorinated biphenyl 153 (CB 153; 2.3-15 ng g-1) and dichlorodiphenyldichloroethylene (p,p’-DDE; 2.3-21 ng g-1), PBDEs (0.03-2.3 ng g-1) and non-PBDE BFRs (0.03-1.5 ng g-1). Non-significant associations of PFR concentrations in feathers with those in plasma (P≥0.74), and their similarity to reported atmospheric PFR concentrations, may suggest atmospheric PFR deposition on feathers. Most OCs and PBDEs, as well as tris(chloroethyl) phosphate (TCEP), tris(phenyl) phosphate (TPHP) and tri-(2-butoxyethyl) phosphate (TBOEP) were associated to δ15N and/or δ13C (all P≤0.02). Besides δ15N enrichment, δ34S was depleted in nestlings from fjords, inherently close to an urbanised centre. As such, both may have been a spatial proxy for anthropogenic disturbance, possible confounding their use as dietary proxy. [less ▲]

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See detailMesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et al

in Nephrology Dialysis Transplantation (2014)

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]

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See detailCarbonate Mounds: from Paradox to World Heritage
Henriet, Jean-Pierre; Hamoumi, N.; Da Silva, Anne-Christine ULg et al

in Marine Geology (2014), 352

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See detailLe Fonds Hubert Nyssen à l'Université de Liège
Durand, Pascal ULg; Habrand, Tanguy ULg

in Histoires littéraires (2014), 58

Biographie croisée de l'écrivain et de l'éditeur Hubert Nyssen et présentation détaillée du Fonds d'archives déposé par lui au Centre d'Etude du Livre Contemporain de l'Université de Liège.

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See detailMagritte y Wittgenstein : acuerdo y desacuerdo
Badir, Sémir ULg

in Tópicos del Seminario (2014), 30

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See detailThe origin of two-dimensional electron gases at oxide interfaces: insights from theory
Bristowe, Nicholas ULg; Ghosez, Philippe ULg; Littlewood, P.B. et al

in Journal of Physics : Condensed Matter (2014), 26

The response of oxide thin films to polar discontinuities at interfaces and surfaces has generated enormous activity due to the variety of interesting effects that it gives rise to. A case in point is the ... [more ▼]

The response of oxide thin films to polar discontinuities at interfaces and surfaces has generated enormous activity due to the variety of interesting effects that it gives rise to. A case in point is the discovery of the electron gas at the interface between LaAlO3 and SrTiO3, which has since been shown to be quasi-two-dimensional, switchable, magnetic and/or superconducting. Despite these findings, the origin of the two-dimensional electron gas is highly debated and several possible mechanisms remain. Here we review the main proposed mechanisms and attempt to model expected effects in a quantitative way with the ambition of better constraining what effects can/cannot explain the observed phenomenology. We do it in the framework of a phenomenological model constructed to provide an understanding of the electronic and/or redox screening of the chemical charge in oxide heterostructures. We also discuss the effect of intermixing, both conserving and not conserving the total stoichiometry. [less ▲]

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See detailLes problèmes liés aux médicaments dans les officines belges
Huysmans; De Wulf, I; Foulon, V et al

in Journal de Pharmacie de Belgique (2014), 1

Abstract INTRODUCTION: The identification, the management and if possible the prevention of drug related problems (DRP), are the main responsibilities of pharmacists. AIM: The aims of the study were 1/to ... [more ▼]

Abstract INTRODUCTION: The identification, the management and if possible the prevention of drug related problems (DRP), are the main responsibilities of pharmacists. AIM: The aims of the study were 1/to investigate the frequency and nature of drug related problems detected by community pharmacists, 2/to inventories the frequency and nature of the interventions by community pharmacists on prescribed medicines, and 3/to evaluate whether there is a difference between DRP detection at the moment of dispensing versus in a quiet setting (a posteriori detection). METHOD: All trainees of the participating universities of Belgian were asked to contribute to a observational study. Participating pharmacists quantified DRP's and their interventions on prescribed medicines for 5 days. Registrations were made by using a web tool based on an adapted version of the classification list of PCNE. The registration took place in two phases, at the time of delivery as well as in an a posteriori verification of the prescriptions with the pharmaceutical record file of the patients. RESULTS: The study was conducted from November 2012 to April 2013 in 534 community-pharmacies with internship. During this period 9.869 prescriptions (15%) with at least one DRP were detected on a total of 64.962 prescriptions treated by tutor pharmacists. Since there could be more than one problem on a prescription, 15.952 DRP's were registered. 2.597 of the DRP's were detected by a posteriori verification. 75% of all problems had a technical cause and 37% were clinical in nature. Under the technical causes an incomplete prescription was the most common. The most frequently registered clinical causes were a drug interaction, an inopportune time of intake, a too high or too low dose and an unsuitable drug. Participating pharmacists solved almost 3 of the 4 detected DRP's. In more than half of the DRP's, the patient was verbally and/or written informed. In 44% of the a posteriori discovered problems, the pharmacist intervened. CONCLUSION: Pharmacist detected one or more DRP's with 15% of the prescriptions. Analysis of a prescription prior to dispensing the medicines therefore appears necessary. The active intervention of the pharmacist in 83% of the problems indicates that he contributes to the optimization of drug therapy with a potential increase in the quality of life of the patient and a reduction in the cost of healthcare. The a posteriori discovered DRP's demonstrate the need for pharmacist lead meditation reviews possibly together with the physician and/or patient. [less ▲]

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See detailThe influence of particle size distribution on sunflower tahini rheology and structure
Mureşan, Vlad; Danthine, Sabine ULg; Racolţa, Emil et al

in Journal of Food Process Engineering (2014)

Different particle size sunflower tahini prototypes were obtained by controlling the milling process of roasted sunflower kernels. Not only the physicochemical properties of these samples but also of an ... [more ▼]

Different particle size sunflower tahini prototypes were obtained by controlling the milling process of roasted sunflower kernels. Not only the physicochemical properties of these samples but also of an industrial reference were compared and discussed in order to understand tahini behavior and structure. Granulometry was determined by a laser-scattering analyzer and revealed for all studied samples, trimodal particle size distributions. Histogram modes, as well as cumulative volume percentages (CVPs) of smal l- and middle-class populations, increased with the number of passes through colloidal mill, while for large particle size population, both the modes and CVPs decreased. Pseudoplastic behavior was observed for all sunflower tahini prototypes and reference, irrespective of studied temperature and particle size. However, the value of consistency coefficient ranged from 3,049 to 6.6 Pa·s n being strong dependent on particle size and temperature while flow behavior indexes between 0.53 and 0.87. Time-dependent rheological analysis revealed higher thixotropic degree of coarser sunflower tahini samples. Studied samples had rheological properties characteristic for a viscoelastic mate- rial, the response in the dynamic frequency sweep being typical for weak gels. The finest sunflower tahini prototype showed the lowest Krieger–Dougherty estimated volume fraction (0.48), while the coarsest sample the highest (0.69), sunflower tahini reference being placed in a median position with a volume fraction of 0.56. By combining all those data, a schematic structure of sunflower tahini was pro- posed for the first time [less ▲]

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See detailTeriparatide Therapy for Denosumab-Induced Osteonecrosis of the Jaw in a Male Osteoporotic Patient.
Neuprez, Audrey; Rompen, Eric ULg; Crielaard, Jean-Michel ULg et al

in Calcified tissue international (2014), 95

We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a male subject with idiopathic osteoporosis. Clinical benefits and CT healing ... [more ▼]

We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a male subject with idiopathic osteoporosis. Clinical benefits and CT healing were obtained within 2 months of teriparatide initiation and denosumab withdrawal. Increase in bone turnover previously described, when denosumab treatment is removed, might have a synergistic effect to the stimulating effect of teriparatide on bone remodeling to promptly heal osteonecrosis of the jaw. [less ▲]

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See detailAnalysis of the global atmospheric methane budget using ECHAM-MOZ simulations for present-day, pre-industrial time and the Last Glacial Maximum
Basu, A.; Schultz, M. G.; Schröder, S. et al

in Atmospheric Chemistry & Physics Discussions (2014), 14

Atmospheric methane concentrations increased considerably from pre-industrial (PI) to present times largely due to anthropogenic emissions. However, firn and ice core records also document a notable rise ... [more ▼]

Atmospheric methane concentrations increased considerably from pre-industrial (PI) to present times largely due to anthropogenic emissions. However, firn and ice core records also document a notable rise of methane levels between the Last Glacial Maximum (LGM) and the pre-industrial era, the exact cause of which is not entirely clear. This study investigates these changes by analyzing the methane sources and sinks at each of these climatic periods. Wetlands are the largest natural source of methane and play a key role in determining methane budget changes in particular in the absence of anthropogenic sources. Here, a simple wetland parameterization suitable for coarse-scale climate simulations over long periods is introduced, which is derived from a high- resolution map of surface slopes together with various soil hydrology parameters from the CARAIB vegetation model. This parameterization was implemented in the chem- istry general circulation model ECHAM5-MOZ and multi-year time slices were run for LGM, PI and present-day (PD) climate conditions. Global wetland emissions from our parameterization are 72 Tg yr [less ▲]

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See detailEffect of fuel and kiln type on the polycyclic aromatic hydrocarbon (PAH) levels in smoked shrimp, a Beninese food condiment
Kpoclou, Euloge; Anihouvi, Victor; Azokpota, Paulin et al

in Food Additives & Contaminants. Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment (2014), 31(7), 1212-1218

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See detailA new Lower Cretaceous ichthyosaur from Russia reveals skull shape conservatism within Ophthalmosaurinae
Fischer, Valentin ULg; Arkhangelsky, Maxim; Uspensky, Gleb et al

in Geological Magazine (2014), 151(1), 60-70

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late ... [more ▼]

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late Jurassic ophthalmosaurine Ophthalmosaurus is often regarded as a hyperspecialized deep diver, very little is known about the anatomy, evolutionary history, and ecology of Cretaceous ophthalmosaurines because of the scarcity of the fossils and the lack of well-preserved skull material. Here, we describe the skull of a new basal ophthalmosaurine ichthyosaur, Leninia stellans gen. et sp. nov., from the lower Aptian of western Russia, and compare the ocular characteristics of ophthalmosaurids. Leninia is recovered as a basal ophthalmosaurine; it possesses unique traits such as star-shaped frontal–parietal sutures as well as features previously thought to be unique to Ophthalmosaurus such as a supratemporal–stapes contact. A large sclerotic aperture – significantly bigger than in platypterygiine ophthalmosaurids and similar to that of the largest-eyed modern animals (giant and colossal squids) – and reduced dentition appear widespread within ophthalmosaurines. This conservatism suggests ophthalmosaurine ophthalmosaurids occupied similar ecological niche(s) throughout their long evolutionary history. [less ▲]

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See detailSound production in Sciaenops ocellatus: Preliminary study for the development of acoustic cues in aquaculture
Parmentier, Eric ULg; Tock, Jérémy; Falguière, Jean-Claude et al

in Aquaculture (2014), 432

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See detailLa Besnoitiose maladie réémergente en Europe
Vanvinckenroye, Caroline ULg; Caron, Yannick ULg; Losson, Bertrand ULg

in Veterinaria (Bruxelles) : Bulletin d’Information de l’Union Syndicale Vétérinaire Belge (2014)

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See detailRADIOTHÉRAPIE MAMMAIRE- pret-à-porter ou sur mesure ?
COUCKE, Philippe ULg; LAKOSI, Ferenc ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 81-86

La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très ... [more ▼]

La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très bien codifiée et peut être taxée de «prêt-à-porter». Et pourtant, on est en droit de se poser la question s’il est possible de concevoir des indications de traitement «sur mesure». A ce jour, les données de la littéra - ture nous incitent à la prudence. Dans aucun cas de figure, on n’a été capable de démontrer que la radiothérapie pouvait être éliminée de l’approche thérapeutique sans pour autant risquer une augmentation significative du taux de rechute locale. Même si on considère que la radiothérapie adjuvante est une approche standard après une chirurgie conservatrice, il n’en reste pas moins qu’il persiste un certain nombre de questions ouvertes. Ces traitements actiniques pourraient être modulables en fonction des caractéristiques des patientes et des tumeurs. Idéalement, nous aimerions disposer de mar - queurs pronostiques et prédictifs robustes afin de détermi - ner qui il faut soumettre à ce traitement adjuvant. Peut-être que des signatures géniques vont permettre de sélectionner les patientes. Ces signatures géniques ne font pas l’unanimité quant à leur réelle portée clinique [less ▲]

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See detailVaricella-zoster virus induces the formation of dynamic nuclear capsid aggregates.
Lebrun, Marielle ULg; Thelen, Nicolas ULg; Thiry, Marc ULg et al

in Virology (2014), 454-455

The first step of herpesviruses virion assembly occurs in the nucleus. However, the exact site where nucleocapsids are assembled, where the genome and the inner tegument are acquired, remains ... [more ▼]

The first step of herpesviruses virion assembly occurs in the nucleus. However, the exact site where nucleocapsids are assembled, where the genome and the inner tegument are acquired, remains controversial. We created a recombinant VZV expressing ORF23 (homologous to HSV-1 VP26) fused to the eGFP and dually fluorescent viruses with a tegument protein additionally fused to a red tag (ORF9, ORF21 and ORF22 corresponding to HSV-1 UL49, UL37 and UL36). We identified nuclear dense structures containing the major capsid protein, the scaffold protein and maturing protease, as well as ORF21 and ORF22. Correlative microscopy demonstrated that the structures correspond to capsid aggregates and time-lapse video imaging showed that they appear prior to the accumulation of cytoplasmic capsids, presumably undergoing the secondary egress, and are highly dynamic. Our observations suggest that these structures might represent a nuclear area important for capsid assembly and/or maturation before the budding at the inner nuclear membrane. [less ▲]

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See detailCombining flux estimation techniques to improve characterization of groundwater–surface-water interaction in the Zenne River, Belgium
Dujardin, Juliette; Anibas, Christian; Bronders, Jan et al

in Hydrogeology Journal (2014)

The management of urban rivers which drain contaminated groundwater is suffering from high uncertainties regarding reliable quantification of groundwater fluxes. Independent techniques are combined for ... [more ▼]

The management of urban rivers which drain contaminated groundwater is suffering from high uncertainties regarding reliable quantification of groundwater fluxes. Independent techniques are combined for estimating these fluxes towards the Zenne River, Belgium. Measured hydraulic gradients, temperature gradients in conjunction with a 1D-heat and fluid transport model, direct flux measurement with the finite volume point dilution method (FVPDM), and a numerical groundwater flow model are applied, to estimate vertical and horizontal groundwaterfluxes and groundwater–surface-water interaction. Hydraulic gradient analysis, the temperature-based method, and the groundwaterflow model yielded average verticalfluxes of–61,–45 and–40 mm/d, respectively. The negative sign indicates upwardflow to the river. Changes in exchangefluxes are sensitive to precipitation but the river remained gaining during the examined period. The FVPDM, compared to the groundwaterflow model, results in two very high estimates of the horizontal Darcyfluxes (2,600 and 500 mm/d), depending on the depth of application. The obtained results allow an evaluation of the temporal and spatial variability of estimated fluxes, thereby helping to curtail possible consequences of pollution of the Zenne River as final receptor, and contribute to the setup of a suitable remediation plan for the contaminated study site. [less ▲]

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See detailExperimental parametric study and design of Piano
Machiels, Olivier; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Research (2014)

Piano Key Weirs are an effective solution for dam rehabilitation as well as new dam projects with a high level of hydraulic constraints. In order to improve the efficiency of their design, an experimental ... [more ▼]

Piano Key Weirs are an effective solution for dam rehabilitation as well as new dam projects with a high level of hydraulic constraints. In order to improve the efficiency of their design, an experimental study of the influence of the main geometric parameters has been performed. Thirty one configurations were tested for a wide range of discharges. The results of the study show the influence of the weir height, the keys widths and the overhangs lengths on the discharge capacity and flow characteristics. Based on hydraulic considerations, optimum values of the main geometric ratios are provided. An analytical formulation is developed to predict the discharge capacity of the weir as a function of its geometry. It shows an accuracy of 10% compared to the experimental results of this study and from other sources. [less ▲]

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See detailDifferential cadmium and zinc distribution in relation to their physiological impact in the leaves of the accumulating Zygophyllum fabago L
LEFÈVRE, Isabelle; VOGEL‐MIKUŠ, Katarina; JEROMEL, Luka et al

in Plant, cell & environment (2014), 37(6), 1299-1320

Cadmium and zinc share many similar physiochemical properties, but their compartmentation, complexation and impact on other mineral element distribution in plant tissues may drastically differ. In this ... [more ▼]

Cadmium and zinc share many similar physiochemical properties, but their compartmentation, complexation and impact on other mineral element distribution in plant tissues may drastically differ. In this study, we address the impact of 10-μM Cd or 50-μM Zn treatment on ion distribution in leaves of a metallicolous population of the non-hyperaccumulating species Zygophyllum fabago at tissue and cell level, and the consequences on the plant response through a combined physiological, proteomic and metabolite approach. Micro-proton induced X-ray emission and laser ablation inductively coupled mass spectrometry analyses indicated hot spots of Cd concentrations in the vicinity of vascular bundles in response to Cd treatment, essentially bound to S-containing compounds as revealed by extended X-Ray absorption fine structure and non-protein thiol compounds analyses. A preferential accumulation of Zn occurred in vascular bundle and spongy mesophyll in response to Zn treatment, and was mainly bound to O/N-ligands. Leaf proteomics and physiological status evidenced a protection of photosynthetically active tissues and the maintenance of cell turgor through specific distribution and complexation of toxic ions, reallocation of some essential elements, synthesis of proteins involved in photosynthetic apparatus or C-metabolism, and metabolite synthesis, with some specificities regarding the considered heavy metal treatment. [less ▲]

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See detailHeart Valve Clinic: Rationale and Organization.
Lancellotti, Patrizio ULg; Rosenhek, Raphael; Pibarot, Philippe

in The Canadian journal of cardiology (2014)

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The ... [more ▼]

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The HVC is made up of a multidisciplinary team with high expertise in the diagnosis, management, treatment, and surveillance of patients with VHD. The aim of the HVC is to provide the highest quality of care to patients with VHD to improve the level of adherence to current evidence and guidelines, quality of life, and short- and long-term outcomes. The HVC also provides help in (1) informing and educating patients to motivate them to take their prescribed medications and look out for signs indicating a worsening of their disease, (2) organizing meetings for updates in knowledge for modern management of patients with VHD, and (3) disseminating protocols of contemporary and good practice in VHD. [less ▲]

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See detailNeuroimaging, cognition, light and circadian rhythms
Gaggioni, Giulia; Maquet, Pierre ULg; Schmidt, Christina et al

in Frontiers in Systems Neuroscience [=FNSYS] (2014)

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See detailAge-related decline in cognitive control: the role of fluid intelligence and processing speed
Manard, Marine ULg; Carabin, Delphine; Jaspar, Mathieu ULg et al

in BMC Neuroscience (2014), 15(7),

Background Research on cognitive control suggests an age-related decline in proactive control abilities whereas reactive control seems to remain intact. However, the reason of the differential age effect ... [more ▼]

Background Research on cognitive control suggests an age-related decline in proactive control abilities whereas reactive control seems to remain intact. However, the reason of the differential age effect on cognitive control efficiency is still unclear. This study investigated the potential influence of fluid intelligence and processing speed on the selective age-related decline in proactive control. Eighty young and 80 healthy older adults were included in this study. The participants were submitted to a working memory recognition paradigm, assessing proactive and reactive cognitive control by manipulating the interference level across items. Results Repeated measures ANOVAs and hierarchical linear regressions indicated that the ability to appropriately use cognitive control processes during aging seems to be at least partially affected by the amount of available cognitive resources (assessed by fluid intelligence and processing speed abilities). Conclusions This study highlights the potential role of cognitive resources on the selective age-related decline in proactive control, suggesting the importance of a more exhaustive approach considering the confounding variables during cognitive control assessment. [less ▲]

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See detailCardiovascular safety of strontium ranelate: real-life assessment in clinical practice.
Donneau, Anne-Françoise ULg; Reginster, Jean-Yves ULg

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

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See detailIn vitro embryo production in goats: slaughterhouse and laparoscopic ovum pick up 2 (LOPU) derived oocytes have different kinetics and requirements regarding maturation 3 media
Souza-Fabjan, JM; Locatelli, Y; Duffard, N et al

in Theriogenology (2014), 81

A total of 3427 goat oocytes were used in this study in order to identify possible 24 differences during in vitro embryo production from slaughterhouse or laparoscopic ovum 25 pick up (LOPU) oocytes. In ... [more ▼]

A total of 3427 goat oocytes were used in this study in order to identify possible 24 differences during in vitro embryo production from slaughterhouse or laparoscopic ovum 25 pick up (LOPU) oocytes. In Experiment 1, one complex, one semi defined and one simplified 26 in vitro maturation (IVM) media were compared using slaughterhouse oocytes. In 27 Experiment 2, we checked the effect of oocyte origin (slaughterhouse or LOPU) on the 28 kinetics of maturation (18 vs. 22 vs. 26 h) when submitted to semi defined or simplified 29 media. In Experiment 3, we determined the differences in embryo development between 30 slaughterhouse and LOPU oocytes when submitted to both media and then to in vitro 31 fertilization (IVF) or parthenogenetic activation (PA). Embryos from all groups were vitrified 32 and their viability evaluated in vitro after thawing. In Experiment 1, no difference (P>0.05) 33 was detected among treatments for maturation rate (MII; 88% on average), cleavage (72%), 34 blastocyst from the initial number of cumulus oocyte complexes (COC; 46%) or from the 35 cleaved ones (63%), hatching rate (69%) and the total number of blastomeres (187). In 36 Experiment 2, there was no difference of MII rate between slaughterhouse oocytes cultured 37 for 18 or 22 h, whereas the MII rate increased significantly (P<0.05) between 18 and 22 h for 38 LOPU oocytes in the simplified medium. Moreover, slaughterhouse oocytes cultured in 39 simplified medium matured significantly faster than LOPU oocytes at 18 and 22 h (P<0.05). 40 In Experiment 3, cleavage rate was significantly greater (P<0.001) in all four groups of 41 embryos produced by PA than IVF. Interestingly, PA reached similar rates for slaughterhouse 42 oocytes cultured in both media, but improved (P<0.05) cleavage rate of LOPU oocytes. 43 Slaughterhouse oocytes had acceptable cleavage rate after IVF (~67%), whereas LOPU 44 oocytes displayed a lower one (~38%), in contrast to cleavage after PA. The percentage of 45 blastocysts in relation to cleaved embryos was not affected by the origin of the oocytes 46 (P>0.05). Therefore, slaughterhouse oocytes developed a greater proportion of blastocysts than LOPU ones, expressed as the percentage of total COC entering to IVM. Vitrified-thawed 48 blastocysts presented similar survival and hatching rates between the oocyte origin, media or 49 method of activation. In conclusion, slaughterhouse and LOPU derived oocytes may have 50 different IVM kinetics and require different IVM-IVF conditions. Although the IVM and IVF 51 systems still need improvements in order to enhance embryo yield, the in vitro development 52 (IVD) step is able to generate good quality embryos from LOPU derived oocytes. [less ▲]

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See detailLinear electro-optic effect in multiferroic BiFeO3 thin films
Sando, D.; Hermet, Patrick ULg; Allibe, J. et al

in Physical Review B (2014), 89

Multiferroics are materials with coexisting magnetic and ferroelectric orders, which show potential for electrically controlled spintronic devices. A common application of ferroelectrics is in electro ... [more ▼]

Multiferroics are materials with coexisting magnetic and ferroelectric orders, which show potential for electrically controlled spintronic devices. A common application of ferroelectrics is in electro-optical modulators exploiting their electric-field-dependent optical indices. The coupling of optical and magnetic degrees of freedom is attractive for designing multifunctional devices, but to date the electro-optical response of multiferroics has hardly been explored. Here we report a joint experimental and theoretical study of this effect in multiferroic BiFeO3 thin films. We confirm the large birefringence present in single crystals and determine the electro-optic coefficients r13 and r33. We present approaches to increase the obtained coefficients, for instance, by using tetragonal-like BiFeO3, and expand the potential of multiferroics to optical applications. [less ▲]

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See detailEvaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2014)

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 ... [more ▼]

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Areas covered: An extensive literature search was performed to analyze the pharmacokinetic characteristics, toxicological issues and safety concerns of SGLT2 inhibitors in humans. This review focuses on three compounds (dapagliflozin, canagliflozin, empagliflozin) with results obtained in healthy volunteers (including drug-drug interactions), patients with T2DM (single dose and multiple doses) and special populations (those with renal or hepatic impairment). Expert opinion: The three pharmacological agents share an excellent oral bioavailability, long half-life allowing once-daily administration, low accumulation index and renal clearance, the absence of active metabolites and a limited propensity to drug-drug interactions. No clinically relevant changes in pharmacokinetic parameters were observed in T2DM patients or in patients with mild/moderate renal or hepatic impairment. Adverse events are a slightly increased incidence of mycotic genital and rare benign urinary infections. SGLT2 inhibitors have the potential to reduce several cardiovascular risk factors, and cardiovascular outcome trials are currently ongoing. The best positioning of SGLT2 inhibitors in the armamentarium for treating T2DM is still a matter of debate. [less ▲]

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See detailCompte rendu de Eugen AFONASIN, John DILLON & John FINAMORE (eds.), "Iamblichus and the Foundations of Late Platonism"
Gavray, Marc-Antoine ULg

in Revue Philosophique de Louvain (2014), 112(1), 167-169

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See detailHuman brucellosis in North-West Ecuador : typifying of Brucella spp., sero-prevalence, and associated risk factors
Ron Roman, J.; Ron Garrido, L.; Abatih, E. et al

in Vector Borne & Zoonotic Diseases (2014), 14(2),

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See detailProtection against muscle damage induced by electrical stimulation: efficiency of a preconditioning programme
Vanderthommen, Marc ULg; Chamayou, Remy; Demoulin, Christophe ULg et al

in Clinical Physiology & Functional Imaging (2014)

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See detailMethods to Increase the Robustness of Finite-Volume Flow Models in Thermodynamic Systems
Quoilin, Sylvain ULg; Bell, Ian ULg; Desideri, Adriano ULg et al

in Energies (2014), 7(3), 1621-1640

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when ... [more ▼]

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when modeling 1D heat exchangers or piping, e.g., in thermodynamic cycles involving a phase change. Issues, such as chattering or stiff systems, can lead to low simulation speed, instabilities and simulation failures. In the particular case of two-phase flow models, they are usually linked to a discontinuity in the density derivative between the liquid and two-phase zones. In this work, several methods to tackle numerical problems are developed, described, implemented and compared. In addition, methods available in the literature are also implemented and compared to the proposed approaches. Results suggest that the robustness of the models can be significantly increased with these different methods, at the price of a small increase of the error in the mass and energy balances. [less ▲]

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See detailDisorders of consciousness after acquired brain injury: the state of the science
Giacino, Joseph T; Fins, Joseph J; Laureys, Steven ULg et al

in Nature Reviews Neurology (2014)

The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain ... [more ▼]

The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain injury results in the dissolution of consciousness, providing a natural model from which key insights about consciousness may be drawn. In the clinical setting, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate through word or gesture, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate and inappropriate care. In this Review, we describe the state of the science with regard to clinical management of patients with prolonged disorders of consciousness. We review consciousness-altering pathophysiological mechanisms, specific clinical syndromes, and novel diagnostic and prognostic applications of advanced neuroimaging and electrophysiological procedures. We conclude with a provocative discussion of bioethical and medicolegal issues that are unique to this population and have a profound impact on care, as well as raising questions of broad societal interest. [less ▲]

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See detailAnxiety and its time courses during radiotherapy for non-metastatic breast cancer: A longitudinal study
Lewis, Florence; Merckaert, Isabelle; Liénard, Aurore et al

in Radiotherapy & Oncology (2014), 111(2), 276-280

Purpose: To our knowledge, no study has specifically assessed the time course of anxiety during radiotherapy (RT). The objective of this study was to assess anxiety time courses in patients with ... [more ▼]

Purpose: To our knowledge, no study has specifically assessed the time course of anxiety during radiotherapy (RT). The objective of this study was to assess anxiety time courses in patients with nonmetastatic breast cancer. Material and methods: This multicenter, descriptive longitudinal study included 213 consecutive patients with breast cancer who completed visual analog scales (VASs) assessing state anxiety before and after the RT simulation and the first and last five RT sessions. Results: Pre- and post-session anxiety mean levels were highest at the RT simulation (respectively, 2.9 ± 2.9 and 1.6 ± 2.5) and first RT session (respectively, 3.4 ± 2.9 and 2.0 ± 2.4), then declined rapidly. Clinically relevant mean differences (P1 cm on the VAS) between pre- and post-simulation/session VAS scores were found only for the RT simulation ( 1.3 ± 2.7; p < 0.001) and first RT session ( 1.4 ± 2.4; p < 0.001). Five percent to 16% of patients presented clinically relevant anxiety (pre- and post-simulation/session VAS scoresP4 cm) throughout treatment. Conclusions: To optimize care, RT team members should offer all patients appropriate information about treatment at the simulation, check patients’ understanding, and identify patients with clinically relevant anxiety requiring appropriate support throughout RT. [less ▲]

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See detailGenetic parameters for direct and maternal calving ease in Walloon dairy cattle based on linear and threshold models
Vanderick, Sylvie ULg; Troch, Thibault ULg; Gillon, Alain et al

in Journal of Animal Breeding & Genetics (2014), in press

Calving ease scores from Holstein dairy cattle in the Walloon Region of Belgium were analysed using univariate linear and threshold animal models. Variance components and derived genetic parameters were ... [more ▼]

Calving ease scores from Holstein dairy cattle in the Walloon Region of Belgium were analysed using univariate linear and threshold animal models. Variance components and derived genetic parameters were estimated from a dataset including 33,155 calving records. Included in the models were season, herd and sex of calf age of dam classes group of calvings interaction as fixed effects, herd year of calving, maternal permanent environment and animal direct and maternal additive genetic as random effects. Models were fitted with the genetic correlation between direct and maternal additive genetic effects either estimated or constrained to zero. Direct heritability for calving ease was about 8% with linear models and about 12% with threshold models. Maternal heritabilities were about 2% and 4%, respectively. Genetic correlation between direct and maternal additive effects was found to be not significantly different from zero. Models were compared in terms of goodness of fit and predictive ability. Criteria of comparison such as mean squared error, correlation between observed and predicted calving ease scores as well as between estimated breeding values were estimated from 85,118 calving records. The results provided few differences between linear and threshold models even though correlations between estimated breeding values from subsets of data for sires with progeny from linear model were 17% and 23 % greater for direct and maternal genetic effects, respectively, than from threshold model. For the purpose of genetic evaluation for calving ease in Walloon Holstein dairy cattle, the linear animal model without covariance between direct and maternal additive effects was found to be the best choice. [less ▲]

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See detailPenser l'espace d'après le "Parménide"
Gavray, Marc-Antoine ULg

in Dialogue : Canadian Philosophical Review = Dialogue : Revue Canadienne de Philosophie (2014)

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See detailA new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms
Sacre, Pierre-Yves ULg; Lebrun, Pierre ULg; Chavez, Pierre-François ULg et al

in Analytica Chimica Acta (2014), 818

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of ... [more ▼]

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of choice for assessing the distributional homogeneity of compounds of interest. Indeed, the combination of both spectroscopic and spatial information provides a detailed knowledge of chemical composition and component distribution. Actually, most authors assess homogeneity using parameters of the histogram of intensities (e.g. mean, skewness and kurtosis). However, this approach does not take into account spatial information and loses the main advantage of imaging. To overcome this limitation, we propose a new criterion: Distributional Homogeneity Index (DHI). DHI has been tested on simulated maps and formulation development samples. The distribution maps of the samples were obtained without validated calibration model since different formulations were under investigation. The results obtained showed a linear relationship between content uniformity values and DHI values of distribution maps. Therefore, DHI methodology appears to be a suitable tool for the analysis of homogeneity of distribution maps even without calibration during formulation development. [less ▲]

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See detailUnintentional "Ventriculo-Phlebo-Myo-Pericardiography"
Gach, Olivier; Lempereur, Mathieu; Eeckhout, Eric et al

in JACC. Cardiovascular Interventions (2014)

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See detailÉLABORATION D’UN PLAN DE FORMATION CONTINUE À PARTIR DE L’APPROCHE PROCESSUS DANS UN SERVICE DE RADIOTHÉRAPIE
LENAERTS, Eric ULg; DELGAUDINE, Marie ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 104-110

Pour garantir l’intégration des évolutions technolo - giques régulières et des changements organisationnels qui en découlent, le Service de Radiothérapie du CHU de Liège, s’est engagé depuis 2007 dans la ... [more ▼]

Pour garantir l’intégration des évolutions technolo - giques régulières et des changements organisationnels qui en découlent, le Service de Radiothérapie du CHU de Liège, s’est engagé depuis 2007 dans la définition et la coordination d’une politique de qualité des soins et de sécurité du patient cohérente et globale. L’équipe dirigeante du service considère la gestion des compétences comme un impératif indispensable afin de pouvoir intégrer rapidement l’utilisation des nouvelles tech - nologies de traitement tout en fournissant de manière continue des soins de haute qualité aux patients. L’approche « proces - sus » consiste à décrire, de façon méthodique, une organisation en processus en vue de contribuer à la satisfaction du patient. Cette approche appliquée dans le service de radiothérapie a permis une meilleure visibilité du fonctionnement du service ainsi qu’une meilleure maîtrise des relations entre les collabo - rateurs et avec les patients. Elle permet de maîtriser la valeur ajoutée de chaque processus, d’identifier les points de risques et d’en anticiper les dérives. Plus précisément, l’approche processus a conduit à préciser les compétences requises pour garantir une haute qualité des soins et à concevoir un plan de formation continue spécifique aux besoins d’un service de radiothérapie. Ce plan a été reconnu au travers de la création d’un certificat universitaire spécifique [less ▲]

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See detailUne Histoire d'hypophyse, évolution des représentations et des concepts au fil du temps.
JEDIDI, Haroun ULg; JEDIDI, Zayd ULg; BECKERS, Albert ULg

in Revue Médicale de Liège (2014)

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez ... [more ▼]

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez paradoxal de constater que malgré l’importance de ce système, celui-ci ait été presque complètement méconnu par les physiologistes des siècles passés. En nous basant sur les conceptions physiologiques des médecins philosophes de l’antiquité puis du moyen-âge et de la renaissance nous tenterons de comprendre pourquoi le rôle de l’hypophyse a été si longtemps méconnu. [less ▲]

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See detailUnited but (un)equal: human capital, probability of divorce, and the marriage contract
Cremer, Helmuh; Pestieau, Pierre ULg; Roeder, Kerstin

in Journal of Population Economics (2014)

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See detailOn the observability of the quark orbital angular momentum distribution
Courtoy, Aurore ULg; Goldstein, Gary R.; Hernandez, J. Osvaldo Gonzalez et al

in Physics Letters B (2014), 731(0), 141-147

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See detailExtraction by three processes of arabinoxylans from wheat bran and characterization of the fractions obtained
Aguedo, Mario ULg; Fougnies, Christian; DERMIENCE, Michael ULg et al

in Carbohydrate Polymers (2014), 105

Arabinoxylans (AXs) were extracted from destarched wheat bran (DWB) according to different processes, with a view to their production at industrial scale. Two fractions (F3a and F3b, respectively purified ... [more ▼]

Arabinoxylans (AXs) were extracted from destarched wheat bran (DWB) according to different processes, with a view to their production at industrial scale. Two fractions (F3a and F3b, respectively purified on 10 kDa and 100 kDa ultrafiltration membranes) were obtained with low yields by treating DWB with an endoxylanase and this process left a solid residue exhausted in enzyme-extractable AXs (EDWB). F1 and F2 AX fractions were obtained by treatment with sodium hydroxide of respectively DWB and EDWB. The fraction F4 resulted from a hydrothermal treatment of EDWB in a pressure reactor, followed by ethanol precipitation. The different AX fractions were characterized and compared for the composition in monosaccharides, for the contents in fats and in ferulic, phytic and uronic acids, for the molecular mass distribution and the degrees of methylation and acetylation. The alkaline extractions gave one desesterified AX population with molecular mass (MM) higher than 670 kDa and arabinose/xylose ratios (Ara/Xyl) around 1. The enzyme and thermal treatments yielded AXs with two main populations in size-exclusion chromatography (the largest one at 5-12.5 kDa and a second one at 140-160 kDa), having overall Ara/Xyl of respectively 0.7 and 0.5 for both processes. These data bring information about the influence of the process on the characteristics of AX fractions obtained from pretreated wheat bran. Here are also reported processes that enabled to recover enzyme-unextractable AXs from DWB, including an original and up-scalable hydrothermal extraction. Phytate contents of isolated AXs are described for the first time. [less ▲]

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See detailImportance de Coula edulis Baill. pour les populations du Sud-Est du Gabon: niveaux de prélèvement et potentiel économique de l’espèce
Moupela, Christian; Vermeulen, Cédric ULg; Doucet, Jean-Louis ULg et al

in Tropicultura (2014), 32(1), 37-45

Coula edulis is a non-timber forest tree species that provides edible fruits for local people. However, its economical importance has never been quantified. The present study aimed to identify the fate of ... [more ▼]

Coula edulis is a non-timber forest tree species that provides edible fruits for local people. However, its economical importance has never been quantified. The present study aimed to identify the fate of stocks of harvested C. edulis fruits in Gabonese villages, emphasizing the social impact and economic income generated by this activity. Our investigations revealed that C. edulis fruits are predominantly utilized for own subsistence, since trading proportion concerned less than 20% of collected fruits. The average income from trade during the harvest period (two months) varied from € 1.7 to € 3.3 per household, depending on the proximity of the market (local or urban). The economical potential of C. edulis fruits could be improved if a sustainable production strategy through domestication processes and agroforestry practices was developed. Such a strategy may also contribute to the increase of the local demand of C. edulis fruits, assuming that a better diffusion was also carried out. [less ▲]

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See detailImpact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning all-SCT from a HLA-identical sibling donor : a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation
Baron, Frédéric ULg; Labopin, M.; Blaise, D. et al

in Bone Marrow Transplantation (2014)

The impact of in vivo T-cell depletion on transplantation outcomes in patients transplanted with reduced-intensity conditioning (RIC) remains controversial. This study assessed the outcome of 1250 adult ... [more ▼]

The impact of in vivo T-cell depletion on transplantation outcomes in patients transplanted with reduced-intensity conditioning (RIC) remains controversial. This study assessed the outcome of 1250 adult patients with de novo AML in first CR (CR1) given PBSC from HLA-identical siblings after chemotherapy-based RIC. A total of 554 patients did not receive any form of in vivo T-cell depletion (control group), whereas antithymocyte globulin (ATG) and alemtuzumab were given in 444 and 252 patients, respectively. The incidences of grade II-IV acute GVHD were 21.4, 17.6 and 10.2% in control, ATG and alemtuzumab patients, respectively (Po0.001). In multivariate analysis, the use of ATG and the use of alemtuzumab were each associated with a lower risk of chronic GVHD (Po0.001 each), but a similar risk of relapse, and of nonrelapse mortality, and similar leukemia-free survival and OS. Further, among patients given BU-based RIC, the use of o6 mg/kg ATG did not increase the risk of relapse (hazard ratio, HR¼1.1), whereas there was a suggestion for higher relapse risk in patients given X6 mg/kg ATG (HR¼1.4, P¼0.08). In summary, these data suggest that a certain amount of in vivo T-cell depletion can be safely used in the conditioning of AML patients in CR1 given PBSC after chemotherapy-based RIC. [less ▲]

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See detailAsymptotic Expansion based-Method for Equivalent Statistical Linearization
Canor, Thomas ULg; Blaise, Nicolas ULg; Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2014)

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See detailL’hypothermie induite dans l'encéphalopathie anox--ischémique du nouveau-né
BARREA, Christophe ULg; Seghaye, Marie-Christine ULg; Battisti, Oreste ULg

in Percentile (2014)

physiopathologie de l'asphyxie à terme et logique des traitements par hypothermie.

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See detailEndothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesis
Heusschen, Roy ULg; Schulkens, Iris; van Beijnum, Judy et al

in Biochimica et Biophysica Acta - Molecular Basis of Disease (2014)

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See detailDie Deutschsprachige Gemeinschaft und die sechste Staatsreform
Behrendt, Christian ULg; Vrancken, Martin ULg

in Europäisches Journal für Minderheitenfragen (2013), Jahr 2013

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See detailDeveloping a Global Food Security Policy
Paveliuc Olariu, Codrin ULg

in Advances in Agriculture & Botanics (2013), 5(3), 169-173

The world agrifood system continues to be in a vulnerable state as we fast approach the 2015 deadline for the Millennium Development Goal of halving the proportion of people suffering from hunger ... [more ▼]

The world agrifood system continues to be in a vulnerable state as we fast approach the 2015 deadline for the Millennium Development Goal of halving the proportion of people suffering from hunger. Although a number of countries have made important changes towards developing food related policies, at the level of the global community, the challenge of food (in)security has not been able push policy makers to develop a common solution to be applied, solution that could include the regional and national specificities registered around the world, while also integrating a global view of increasing agricultural productivity, higher farm competitiveness and without relinquishing the national or individual right for food governance. [less ▲]

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See detailFood scarcity as a trigger for civil unrest
Paveliuc Olariu, Codrin ULg

in Advances in Agriculture & Botanics (2013), 5(3), 174-178

Throughout history, there have been periods of civil unrest. From religious wars to wars of conquest, historians believe that the causes of wars are closely related with religious, political or economic ... [more ▼]

Throughout history, there have been periods of civil unrest. From religious wars to wars of conquest, historians believe that the causes of wars are closely related with religious, political or economic reasons. But when we discuss about civil unrest inside a country with the power of transforming it into a civil war and expanding at regional level, the triggering factors have yet to be discovered. From the period of the Qing Dinasty (1644-1911) in China to the Great Depression in the 1930s in the USA or the beginning of the second World War in France, these periods have two common points: civil unrest and food shortages. [less ▲]

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See detailIs the multicolored Asian ladybeetle, Harmonia axyridis, the most abundant natural enemy to aphids in agroecosystems?
Vandereycken, Axel ULg; Durieux, Delphine ULg; Joie, Emilie ULg et al

in Journal of Insect Science [=JIS] (2013), 13(158), 1-14

The multicolored Asian ladybeetle, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was introduced into Western Europe in the late 1990s. Since the late 2000s, this species has been commonly ... [more ▼]

The multicolored Asian ladybeetle, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was introduced into Western Europe in the late 1990s. Since the late 2000s, this species has been commonly considered one of the most abundant aphid predators in most Western European coun- tries. In spite of the large amount of research on H. axyridis, information concerning its relative abundance in agroecosystems is lacking. This study aims to evaluate the abundance of H. axyridis within the aphidophage community in four crops situated in southern Belgium: wheat, Triticum aestivum L. (Poales: Poaceae), corn, Zea mays, potato, Solanum tuberosum (Solanales: Solanaceae), and broad bean Vicia faba (Fabales: Fabaceae). In order to assess the species diver- sity, the collected data were analyzed by considering (1) the species richness and (2) the evenness according to the Shannon diversity index. Eleven aphidophages were observed in every invento- ried agroecosystem, including five abundant species: three coccinellids, the seven-spotted ladybug, Coccinella septempunctata L. (Coleoptera: Coccinellidae), the 14-spotted Ladybird, Propylea quatuordecimpunctata, and H. axyridis; one hoverfly, the marmalade hoverfly, Episyr- phus balteatus De Geer (Diptera: Syrphidae); and one lacewing, the common green lacewing, Chrysoperla carnea Stephens sensu lato (= s.l.) (Neuroptera: Chrysopidae). Harmonia axyridis has been observed to thrive, breed, and reproduce on the four studied crops. Harmonia axyridis is the most abundant predator of aphids in corn followed by C. septempunctata, which is the main aphid predator observed in the three other inventoried crops. In wheat and potato fields, H. axyridis occurs in low numbers compared to other aphidophage. These observations suggest that H. axyridis could be considered an invasive species of agrosystems, and that potato and wheat may intermittently act as refuges for other aphidophages vulnerable to intraguild predation by this invader. Harmonia axyridis is not the most abundant aphid predator in the main Belgian crops. [less ▲]

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See detailVerbal overshadowing of face memory does occur in children too!
Dehon, Hedwige ULg; Vanootighem, Valentine ULg; Brédart, Serge ULg

in Frontiers in Psychology (2013)

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See detailLe mécanisme des versements anticipés d'impôts et le budget prévisionnel y afférent
Niessen, Wilfried ULg; Bils, Anne ULg

in PACIOLI (Institut Professionnel des Comptables et Fiscalistes agréés) (2013)

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See detailAssessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo
Mvumbi, Dieudonné; BOREUX, Raphaël ULg; SACHELI, Rosalie ULg et al

in Malaria Journal (2013), 12

BACKGROUND: In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies ... [more ▼]

BACKGROUND: In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype. This haplotype was first identified in Southeast Asia and South America but was recently reported in two African countries neighbouring DRC. These facts raised two questions: the first about the evolution of CQ resistance (CQR) in DRC and the second about the presence of the SVMNT haplotype, which would compromise the use of AQ as a partner drug for ACT. METHODS: A total of 213 thick blood films were randomly collected in 2010 from a paediatric clinic in Kinshasa, DRC. Microscopy controls and real-time polymerase chain reaction (RT-PCR) were performed for Plasmodium species identification. Haplotypes of the pfcrt gene were determined by sequencing. RESULTS: The K76T mutation was detected in 145 out of 198 P. falciparum-positive samples (73.2%).In these 145 resistant strains, only the CVIET haplotype was detected. CONCLUSIONS: This study is the first to assess the molecular markers of resistance to CQ and AQ after the introduction of ACT in DRC. The results suggest first that CQR is decreasing, as wild-type pfcrt haplotypes were found in only 26.8% of the samples and secondly that the SVMNT haplotype is not yet present in Kinshasa, suggesting that AQ remains valid as a partner drug for ACT in this region. [less ▲]

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See detailOn the Encoding of Proteins for Disordered Regions Prediction
Becker, Julien ULg; Maes, Francis; Wehenkel, Louis ULg

in PLoS ONE (2013)

Disordered regions, i.e., regions of proteins that do not adopt a stable three-dimensional structure, have been shown to play various and critical roles in many biological processes. Predicting and ... [more ▼]

Disordered regions, i.e., regions of proteins that do not adopt a stable three-dimensional structure, have been shown to play various and critical roles in many biological processes. Predicting and understanding their formation is therefore a key sub-problem of protein structure and function inference. A wide range of machine learning approaches have been developed to automatically predict disordered regions of proteins. One key factor of the success of these methods is the way in which protein information is encoded into features. Recently, we have proposed a systematic methodology to study the relevance of various feature encodings in the context of disulfide connectivity pattern prediction. In the present paper, we adapt this methodology to the problem of predicting disordered regions and assess it on proteins from the 10th CASP competition, as well as on a very large subset of proteins extracted from PDB. Our results, obtained with ensembles of extremely randomized trees, highlight a novel feature function encoding the proximity of residues according to their accessibility to the solvent, which is playing the second most important role in the prediction of disordered regions, just after evolutionary information. Furthermore, even though our approach treats each residue independently, our results are very competitive in terms of accuracy with respect to the state-of-the-art. A web-application is available at http://m24.giga.ulg.ac.be:81/x3Disorder. [less ▲]

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See detailSémiotique de la communication en co-présence et à distance. Du textualisme à la sémiotique des pratiques
Dondero, Maria Giulia ULg; Angenot, Valérie ULg; Joachim, Guillaume ULg et al

in Interfaces Numériques (2013), 2(3), 531-567

This article aims to challenge and reflect on the theories issued by both textualist semiotics and the semiotics of practices. Our reflexion shall focus, on the one hand, on synchronic communication in ... [more ▼]

This article aims to challenge and reflect on the theories issued by both textualist semiotics and the semiotics of practices. Our reflexion shall focus, on the one hand, on synchronic communication in copresence and, on the other hand, on virtual participative remote collaboration by means of digital interfaces. In high-level collaborative activities —such as remote architectural project developments— the practices of the partners involved in the communication process are conditioned by intrinsic material constraints; they have to gradually readapt to the constantly renewed dynamics of the predicative structures in order to ensure communication efficiency. One of the main purposes of this paper consists in exploring the theoretical propositions and methodologies connected to practices, as proposed by Jacques Fontanille’s semiotics (2008) and by Jacques Theureau’s ergonomics of the “course of action” (2006). The results of these theoretical reflections will be tested through their application to a specific corpus, in an aim to confront the efficiency of such proposals with a case study. Multimodality and the role played by the different types of utterances in the efficiency of communication, as well as the adaptation of the semiotic practices to the digital interfaces also fall under the scope of this paper. Besides, the authors propose a reflection on potential mediations between the ongoing practices and their objectivation through textualisation and notation. [less ▲]

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See detailClassification of the algebras $\mathbb{O}_{p,q}$
Kreusch, Marie ULg; Morier-Genoud, Sophie

in Communications in Algebra (2013)

We study a series of real nonassociative algebras $O_{p,q}$ introduced in [5]. These algebras have a natural $Z^n_2$-grading, where $n = p + q$, and they are characterized by a cubic form over the field $Z ... [more ▼]

We study a series of real nonassociative algebras $O_{p,q}$ introduced in [5]. These algebras have a natural $Z^n_2$-grading, where $n = p + q$, and they are characterized by a cubic form over the field $Z_2$. We establish all the possible isomorphisms between the algebras $O_{p,q}$ preserving the structure of $Z^n_2$-graded algebra. The classification table of $O_{p,q}$ is quite similar to that of the real Clifford algebras $Cl_{p,q}$, the main difference is that the algebras $O_{n,0}$ and $O_{0,n}$ are exceptional. [less ▲]

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See detailReintroduction of the invasive mosquito species Aedes albopictus in Belgium in July 2013
Boukraa, Slimane ULg; Raharimalala, Fara Nantenaina ULg; Zimmer, Jean-Yves ULg et al

in Parasite (Paris, France) (2013), 20(54),

Since its first report in 2000, the invasive mosquito Aedes albopictus was not found any more during the different entomological inspections performed at its place of introduction in Belgium between 2001 ... [more ▼]

Since its first report in 2000, the invasive mosquito Aedes albopictus was not found any more during the different entomological inspections performed at its place of introduction in Belgium between 2001 and 2012. In July 2013, one adult male was captured at the same site (a platform of imported used tires located in Vrasene, Oost-Vlaanderen Province), during a monitoring using CO2-baited trap. This finding suggests the reintroduction of the species in Belgium via the used tire trade. [less ▲]

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See detailModeling of Wastewater Sludge Drying with Determination of Diffusivity Moisture
Bennamoun, Lyes ULg; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Journal of Residuals Science and Technology [=JRST] (2013), 10(4), 165

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See detailInfluence of ovarian hormones on cortical spreading depression and its suppression by L-kynurenine in rat.
Chauvel, Virginie ULg; Schoenen, Jean ULg; Multon, Sylvie ULg

in PLoS ONE (2013), 8(12), 82279

Migraine is sexually dimorphic and associated in 20-30% of patients with an aura most likely caused by cortical spreading depression (CSD). We have previously shown that systemic L-kynurenine (L-KYN), the ... [more ▼]

Migraine is sexually dimorphic and associated in 20-30% of patients with an aura most likely caused by cortical spreading depression (CSD). We have previously shown that systemic L-kynurenine (L-KYN), the precursor of kynurenic acid, suppresses CSD and that this effect depends on the stage of the estrous cycle in female rats. The objectives here are to determine the influence of ovarian hormones on KCl-induced CSD and its suppression after L-KYN by directly modulating estradiol or progesterone levels in ovariectomized rats. Adult female rats were ovariectomized and subcutaneously implanted with silastic capsules filled with progesterone or 17β-estradiol mixed with cholesterol, with cholesterol only or left empty. Two weeks after the ovariectomy/capsule implantation, the animals received an i.p. injection of L-KYN (300 mg/kg) or NaCl as control. Thirty minutes later CSDs were elicited by applying KCl over the occipital cortex and recorded by DC electrocorticogram for 1 hour. The results show that both estradiol and progesterone increase CSD frequency after ovariectomy. The suppressive effect of L-KYN on CSD frequency, previously reported in normal cycling females, is not found anymore after ovariectomy, but reappears after progesterone replacement therapy. Taken together, these results emphasize the complex role of sex hormones on cortical excitability. The CSD increase by estradiol and, more surprisingly, progesterone may explain why clinically migraine with aura appears or worsens during pregnancy or with combined hormonal treatments. [less ▲]

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See detailLa cloche Lovinfosse du Trésor de la Cathédrale de Liège
Marganne, Marie-Hélène ULg; Mélard, Marc

in Bloc-Notes : Bulletin périodique du Trésor de la Cathédrale de Liège (2013), 37

Examen de la cloche de bronze J.F. Lovinfosse 1818 provenant du Couvent des Filles de la Croix, rue Hors-Château, à Liège, et conservée au Trésor de la Cathédrale de Liège.

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See detailPoly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release
Liu, Ji ULg; Detrembleur, Christophe ULg; Debuigne, Antoine ULg et al

in Nanoscale (2013), 5(23), 11464-11477

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug ... [more ▼]

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions and furthermore, improve the biocompatibility and in vivo circulation half-time of the maghemite nanoparticles. Drug loading capacity was evaluated with methylene blue (MB), a cationic model drug. The triggered release of MB was studied under various stimuli such as pH, ionic strength and temperature. Local heating generated under alternating magnetic field (AMF) application was studied, and remotely AMF-triggered release was also confirmed, while a mild heating-up of the release medium was observed. Furthermore, their potential application as magnetic resonance imaging (MRI) contrast agents was explored via relaxivity measurements and acquisition of T2-weighted images. Preliminary studies on the cytotoxicity against mouse fibroblast-like L929 cell line and also their cellular uptake within human melanoma MEL-5 cell line were carried out. In conclusion, this kind of stimuli-responsive nanoparticles appears to be promising carriers for delivering drugs to some tumour sites or into cellular compartments with an acidic environment. [less ▲]

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See detailPubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction.
Franssen, Delphine ULg; Ioannou, Yiannis S.; Alvarez-Real, Alexandra et al

in Reproductive toxicology (Elmsford, N.Y.) (2013)

We studied the effects of neonatal exposure to diethylstilbestrol (DES) on pubertal timing in female rats. We examined associated neuroendocrine changes and effects of prenatal food restriction. Age at ... [more ▼]

We studied the effects of neonatal exposure to diethylstilbestrol (DES) on pubertal timing in female rats. We examined associated neuroendocrine changes and effects of prenatal food restriction. Age at vaginal opening was advanced after exposure to 10mug/kg/d of DES and delayed after 1mug/kg/d (subcutaneous injections). Using this lower dose, pulsatile GnRH secretion was slower at 25 days of age. Both doses reduced KiSS1 mRNA levels at 15 days of age. Using functional Kisspeptin promoter assay, 1 or 10muM DES reduced or increased KISS1 transcription, respectively. Leptin stimulatory effect on GnRH secretion in vitro (15 days of age) was reduced after prenatal food restriction and neonatal DES exposure (higher dose), both effects being cumulative. Thus, alterations in pubertal timing by DES neonatally are not unequivocally toward precocity, the level of exposure being critical. We provide evidence of neuroendocrine disruption and interaction with prenatal food availability. [less ▲]

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See detailInversion of a part of the numerator relationship matrix using pedigree information
Faux, Pierre ULg; Gengler, Nicolas ULg

in Genetics, Selection, Evolution (2013), 45

Background. In recent theoretical developments, the information available (e.g. genotypes) divides the original population into two groups: animals with this information (selected animals) and animals ... [more ▼]

Background. In recent theoretical developments, the information available (e.g. genotypes) divides the original population into two groups: animals with this information (selected animals) and animals without this information (excluded animals). These developments require inversion of the part of the pedigree-based numerator relationship matrix that describes the genetic covariance between selected animals (A22). Our main objective was to propose and evaluate methodology that takes advantage of any potential sparsity in the inverse of A22 in order to reduce the computing time required for its inversion. This potential sparsity is brought out by searching the pedigree for dependencies between the selected animals. Jointly, we expected distant ancestors to provide relationship ties that increase the density of matrix A22 but that their effect on A22i might be minor. This hypothesis was also tested. Methods. The inverse of A22 can be computed from the inverse of the triangular factor (T-1 ) obtained by Cholesky root-free decomposition of A22 . We propose an algorithm that sets up the sparsity pattern of T-1 using pedigree information. This algorithm provides positions of the elements of T-1 worth to be computed (i.e. different from zero). A recursive computation of A22i is then achieved with or without information on the sparsity pattern and time required for each computation was recorded. For three numbers of selected animals (4000; 8000 and 12 000), A22 was computed using different pedigree extractions and the closeness of the resulting A22i to the inverse computed using the fully extracted pedigree was measured by an appropriate norm. Results. The use of prior information on the sparsity of T-1 decreased the computing time for inversion by a factor of 1.73 on average. Computational issues and practical uses of the different algorithms were discussed. Cases involving more than 12 000 selected animals were considered. Inclusion of 10 generations was determined to be sufficient when computing A22. Conclusions. Depending on the size and structure of the selected sub-population, gains in time to compute A22 are possible and these gains may increase as the number of selected animals increases. Given the sequential nature of most computational steps, the proposed algorithm can benefit from optimization and may be convenient for genomic evaluations. [less ▲]

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See detailElectroencephalogram approximate entropy influenced by both age and sleep
Lee, Gerick; Fattinger, Sara; Mouthon, Anne-Laure et al

in Frontiers in Neuroinformatics (2013), 7(33),

The use of information-based measures to assess changes in conscious state is an increasingly popular topic. Though recent results have seemed to justify the merits of such methods, little has been done ... [more ▼]

The use of information-based measures to assess changes in conscious state is an increasingly popular topic. Though recent results have seemed to justify the merits of such methods, little has been done to investigate the applicability of such measures to children. For our work, we used the approximate entropy (ApEn), a measure previously shown to correlate with changes in conscious state when applied to the electroencephalogram (EEG), and sought to confirm whether previously reported trends in adult ApEn values across wake and sleep were present in children. Besides validating the prior findings that ApEn decreases from wake to sleep (including wake, rapid eye movement (REM) sleep, and non-REM sleep) in adults, we found that previously reported ApEn decreases across vigilance states in adults were also present in children (ApEn trends for both age groups: wake > REM sleep > non-REM sleep). When comparing ApEn values between age groups, adults had significantly larger ApEn values than children during wakefulness. After the application of an 8 Hz high-pass filter to the EEG signal, ApEn values were recalculated. The number of electrodes with significant vigilance state effects dropped from all 109 electrodes with the original 1 Hz filter to 1 electrode with the 8 Hz filter. The number of electrodes with significant age effects dropped from 10 to 4. Our results support the notion that ApEn can reliably distinguish between vigilance states, with low-frequency sleep-related oscillations implicated as the driver of changes between vigilance states. We suggest that the observed differences between adult and child ApEn values during wake may reflect differences in connectivity between age groups, a factor which may be important in the use of EEG to measure consciousness. [less ▲]

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See detailEffect of bovine colostrum administration on plasma protein profile, growth, and survival in Red kid.
Abdou, Harouna ULg; Marichatou, Hamani; Beckers, Jean-François ULg et al

in Small Ruminant Research (2013), 117

This study evaluated the effect of colostrum from Azawak cows on plasma protein profile, 24 growth, and survival in Red kids from Niger. Forty (40) newborn kids were allocated to one 25 of two treatment ... [more ▼]

This study evaluated the effect of colostrum from Azawak cows on plasma protein profile, 24 growth, and survival in Red kids from Niger. Forty (40) newborn kids were allocated to one 25 of two treatment-groups: control (free access to water and the mother) and colostrum (free 26 access to water and the mother, but with additional 50 mL of colostrum/animal/day of birth 27 and 25 mL/animal/day from the 2nd to 15th day of age). Blood samples were collected into 28 EDTA vacutainer tubes by jugular puncture at 10 and 30 days of age. Total protein was 29 quantified by the Biuret method. The agarose gel electrophoresis was used to determine the 30 serum levels of albumin, -globulin, β1-globulin, β2-globulin, γ-globulin and the 31 albumin/globulin ratio. The animals from the colostrum group showed higher body weight 32 and average daily gain when compared to the control group (P < 0.001). The average 33 concentration in protein at the both sampling times reached higher values in the colostrum 34 than in the control group. At D10, the colostrum group tended (P < 0.07) to show higher 35 levels of -globulin and had higher values (P < 0.05) for β1-globulin. At D30, total protein 36 and β2-globulins were higher in colostrum group. Colostrum from Azawak cows seems to 37 have positive effects on some plasma proteins levels and on growth rate in Red kids. [less ▲]

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See detailInactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism.
Massoz, Simon; Larosa, Véronique ULg; Plancke, Charlotte et al

in Mitochondrion (2013)

In Chlamydomonas, unlike in flowering plants, genes coding for Nd7 (NAD7/49kDa) and Nd9 (NAD9/30kDa) core subunits of mitochondrial respiratory-chain complex I are nucleus-encoded. Both genes possess all ... [more ▼]

In Chlamydomonas, unlike in flowering plants, genes coding for Nd7 (NAD7/49kDa) and Nd9 (NAD9/30kDa) core subunits of mitochondrial respiratory-chain complex I are nucleus-encoded. Both genes possess all the features that facilitate their expression and proper import of the polypeptides in mitochondria. By inactivating their expression by RNA interference or insertional mutagenesis, we show that both subunits are required for complex I assembly and activity. Inactivation of complex I impairs the cell growth rate, reduces the respiratory rate, leads to lower intracellular ROS production and lower expression of ROS scavenging enzymes, and is associated to a diminished capacity to concentrate CO2 without compromising photosynthetic capacity. [less ▲]

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See detailOn protocols and measures for the validation of supervised methods for the inference of biological networks
Schrynemackers, Marie ULg; Kuffner, Robert; Geurts, Pierre ULg

in Frontiers in genetics (2013), 4(262),

Networks provide a natural representation of molecular biology knowledge, in particular to model relationships between biological entities such as genes, proteins, drugs, or diseases. Because of the ... [more ▼]

Networks provide a natural representation of molecular biology knowledge, in particular to model relationships between biological entities such as genes, proteins, drugs, or diseases. Because of the effort, the cost, or the lack of the experiments necessary for the elucidation of these networks, computational approaches for network inference have been frequently investigated in the literature. In this paper, we examine the assessment of supervised network inference. Supervised inference is based on machine learning techniques that infer the network from a training sample of known interacting and possibly non-interacting entities and additional measurement data. While these methods are very effective, their reliable validation in silico poses a challenge, since both prediction and validation need to be performed on the basis of the same partially known network. Cross-validation techniques need to be specifically adapted to classification problems on pairs of objects. We perform a critical review and assessment of protocols and measures proposed in the literature and derive specific guidelines how to best exploit and evaluate machine learning techniques for network inference. Through theoretical considerations and in silico experiments, we analyze in depth how important factors influence the outcome of performance estimation. These factors include the amount of information available for the interacting entities, the sparsity and topology of biological networks, and the lack of experimentally verified non-interacting pairs. [less ▲]

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See detailA Photometric Study of the Hot Exoplanet WASP-19b
Lendl, M.; Gillon, Michaël ULg; Queloz, D. et al

in Astronomy and Astrophysics (2013), 552

Context. The sample of hot Jupiters that have been studied in great detail is still growing. In particular, when the planet transits its host star, it is possible to measure the planetary radius and the ... [more ▼]

Context. The sample of hot Jupiters that have been studied in great detail is still growing. In particular, when the planet transits its host star, it is possible to measure the planetary radius and the planet mass (with radial velocity data). For the study of planetary atmospheres, it is essential to obtain transit and occultation measurements at multiple wavelengths. Aims: We aim to characterize the transiting hot Jupiter WASP-19b by deriving accurate and precise planetary parameters from a dedicated observing campaign of transits and occultations. Methods: We have obtained a total of 14 transit lightcurves in the r'-Gunn, I-Cousins, z'-Gunn, and I + z' filters and 10 occultation lightcurves in z'-Gunn using EulerCam on the Euler-Swiss telescope and TRAPPIST. We also obtained one lightcurve through the narrow-band NB1190 filter of HAWK-I on the VLT measuring an occultation at 1.19 μm. We performed a global MCMC analysis of all new data, together with some archive data in order to refine the planetary parameters and to measure the occultation depths in z'-band and at 1.19 μm. Results: We measure a planetary radius of Rp = 1.376 ± 0.046 RJ, a planetary mass of Mp = 1.165 ± 0.068 MJ, and find a very low eccentricity of e = 0.0077-0.0032+0.0068, compatible with a circular orbit. We have detected the z'-band occultation at 3σ significance and measure it to be δFocc,z' = 352 ± 116 ppm, more than a factor of 2 smaller than previously published. The occultation at 1.19 μm is only marginally constrained at δFocc,NB1190 = 1711-726+745 ppm. Conclusions: We show that the detection of occultations in the visible range is within reach, even for 1 m class telescopes if a considerable number of individual events are observed. Our results suggest an oxygen-dominated atmosphere of WASP-19b, making the planet an interesting test case for oxygen-rich planets without temperature inversion. [less ▲]

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See detailWR 138: new results from X-ray and optical spectroscopy
Palate, Matthieu ULg; Rauw, Grégor ULg; De Becker, Michaël ULg et al

in Astronomy and Astrophysics (2013), 560

Massive-binary evolution models predict that some systems will go through an evolutionary phase where the original primary has become a supernova and left a compact object behind that then orbits a Wolf ... [more ▼]

Massive-binary evolution models predict that some systems will go through an evolutionary phase where the original primary has become a supernova and left a compact object behind that then orbits a Wolf-Rayet (WR) star. WR 138 is an X-ray bright WR star that has been described as a triple system, including a compact companion in a short-period orbit. Our goal is to search for spectroscopic evidence of a compact companion around WR 138. We used optical and X-ray spectra to search for signatures of a compact companion, which can be revealed by systematic variations in WR optical spectral lines induced by orbital motion of the compact companion or by hard, luminous X-rays from accretion onto this companion. The optical spectra display emission-line profile variations that are most probably caused by clumps inside the stellar winds. The radial velocities do not vary on a short time-scale compatible with the suggested orbital period of a putative compact companion. The X-ray spectra are found to be normal for a WN5-6+OB system with no indication of accretion by a compact companion. There is no evidence for the presence of a compact companion, and we therefore conclude that WR 138 is a normal long-period (P ~ 1521 d) eccentric WR+OB system. [less ▲]

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See detailEarly-type stars observed in the ESO UVES Paranal Observatory Project - IV. Studies of CN, CH+ and CH in the interstellar medium
Smoker, J.; Ledoux, C.; Jehin, Emmanuel ULg et al

in Monthly Notices of the Royal Astronomical Society (2013)

High spectral resolution (˜80 000) and signal-to-noise observations from the Ultraviolet and Visual Echelle Spectrograph Paranal Observatory Project (UVES-POP) are used to study the interstellar molecular ... [more ▼]

High spectral resolution (˜80 000) and signal-to-noise observations from the Ultraviolet and Visual Echelle Spectrograph Paranal Observatory Project (UVES-POP) are used to study the interstellar molecular lines CN (3874 Å), CH[SUP]+[/SUP] (3957, 4232 Å) and CH (3886, 4300 Å) towards 74 O- and B-type stellar sightlines. Additionally, archive data are presented for 140 ELODIE early-type stellar sightlines at R = 42 000, plus 25 FEROS at R = 48 000 and 3 UVES at R > 50 000, mainly in the CH[SUP]+[/SUP] (4232 Å) and CH (3886, 4300 Å) transitions. Detection rates are ˜45 per cent for CN and ˜67 per cent for the other lines in the POP sample, and ˜10-15 per cent for CH[SUP]+[/SUP] and CH lines in the additional sample. CH and CH[SUP]+[/SUP] are well correlated between log[N(CH) cm[SUP]-2[/SUP]]˜12-14, implying that these clouds are CH[SUP]+[/SUP]-like CH and not CN-like CH. CH is also very well correlated with Na I D in the range log[N(Na I cm[SUP]-2[/SUP]]) ˜12.2-14.2. A few sightlines show tentative velocity shifts of ˜2 km s[SUP]-1[/SUP] between CH and CH[SUP]+[/SUP], which appear to be caused by differences in component strength in blends, and hence do not provide firm evidence for shocks. Finally, we describe a search for [SUP]13[/SUP]CH[SUP]+[/SUP] in a sightline towards HD 76341. No [SUP]13[/SUP]CH[SUP]+[/SUP] is detected, placing a limit on the [SUP]13[/SUP]CH[SUP]+[/SUP] to [SUP]12[/SUP]CH[SUP]+[/SUP] ratio of ˜0.01. If a formal fit is attempted, the equivalent width ratio in the two isotopes is a factor ˜90 but with large errors. [less ▲]

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See detailPreliminary description of the diet of Hippopotamus amphibius L. in Loango National Park (Gabon)
Michez, Adrien ULg; Doucet, Jean-Louis ULg; Dendocker, Nicolas et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(4), 580-583

Due to the paucity of suitable habitat, hippos are very rare in the Congo Bassin. Compared to East-African populations, Central African populations of hippos have been less studied. Information found in ... [more ▼]

Due to the paucity of suitable habitat, hippos are very rare in the Congo Bassin. Compared to East-African populations, Central African populations of hippos have been less studied. Information found in the literature regarding the animal’s basic ecology is limited. This study focuses on the description of the diet of an isolated hippo population in Loango National Park (Gabon), comparing faecal analysis with a reference collection ofherbaceous species from the savannas. The effectiveness of using faecal analysis versus using the floristic description of hippos’ pastures was demonstrated. The most frequent herbaceous species identified in faeces samples were Paspalum vaginatum, Axonopus compressus, Stenotaphrum secundatum (Poaceae) and Desmodium triflorum (Fabaceae). The voluntary consumption of a dicotyledonous species (Desmodium triflorum) is novel for this species. [less ▲]

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