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See detailCan we use circulating biomarkers to monitor bone turnover in CKD haemodialysis patients? Hypotheses and facts
DELANAYE, Pierre ULg; Souberbielle, Jean-Claude; Lafage-Proust, Marie-Hélène et al

in Nephrology Dialysis Transplantation (2014), 29(5), 997-1004

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical ... [more ▼]

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical practice and because bone histomorphometry is less available due to the lack of specialized laboratories, we will focus on potential biomarkers used to assess and monitor bone turnover. After briefly reviewing the pathophysiology of bone turnover in CKD and haemodialysis patients, we will focus on the strengths and limitations of the now recommended biomarkers, i.e. parathormone and bone-specific alkaline phosphatase. We will consider the clinical and also the biological aspects of the topic and also insist on the use of these biomarkers for the monitoring, and the follow-up of the turnover in haemodialysis subjects. Finally, we will discuss some of the most promising, but still not recommended, emerging biomarkers. [less ▲]

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See detailThe XMM-Newton view of the yellow hypergiant IRC+10420 and its surroundings
De Becker, Michaël ULg; Hutsemekers, Damien ULg; Gosset, Eric ULg

in New Astronomy (2014), 29

Among evolved massive stars likely in transition to the Wolf-Rayet phase, IRC +10420 is probably one of the most enigmatic. It belongs to the category of yellow hypergiants and it is characterized by ... [more ▼]

Among evolved massive stars likely in transition to the Wolf-Rayet phase, IRC +10420 is probably one of the most enigmatic. It belongs to the category of yellow hypergiants and it is characterized by quite high mass loss episodes. Even though IRC+10420 benefited of many observations in several wavelength domains, it has never been a target for an X-ray observatory. We report here on the very first dedicated observation of IRC+10420 in X-rays, using the XMM-Newton satellite. Even though the target is not detected, we derive X-ray flux upper limits of the order of 1–3 ×10−14 erg cm−2 s−1 (between 0.3 and 10.0 keV), and we discuss the case of IRC+10420 in the framework of emission models likely to be adequate for such an object. Using the Optical/UV Monitor on board XMM-Newton, we present the very first upper limits of the flux density of IRC +10420 in the UV domain (between 1800 and 2250 Å and between 2050 and 2450 Å). Finally, we also report on the detection in this field of 10 X-ray and 7 UV point sources, and we briefly discuss their properties and potential counterparts at longer wavelengths. [less ▲]

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See detailFactors associated with clinical inertia: an integrative review
Aujoulat, I; Jacquemin, p; Rietzschel, E et al

in Advances in Medical Education and Practice (2014), 5

Failure to initiate or intensify therapy according to evidence-based guidelines is increasingly being acknowledged as a phenomenon that contributes to inadequate management of chronic conditions, and is ... [more ▼]

Failure to initiate or intensify therapy according to evidence-based guidelines is increasingly being acknowledged as a phenomenon that contributes to inadequate management of chronic conditions, and is referred to as clinical inertia. However, the number and complexity of factors associated with the clinical reasoning that underlies the decision-making processes in medicine calls for a critical examination of the consistency of the concept. Indeed, in the absence of information on and justification of treatment decisions that were made, clinical inertia may be only apparent, and actually reflect good clinical practice. This integrative review seeks to address the factors generally associated with clinical inaction, in order to better delineate the concept of true clinical inertia. [less ▲]

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See detailCapillary-driven bi-dimensional buoyancy in vertical soap films
Adami, Nicolas ULg; Caps, Hervé

in Europhysics Letters [=EPL] (2014)

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See detailMDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Shostak, Kateryna ULg; Patrascu, F.; Göktuna, Serkan ULg et al

in Cell death and differentiation (2014), 5(21), 811-24

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because ... [more ▼]

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because the MDM2 targetome extends beyond p53, MDM2 inhibition may also cause unwanted activation of oncogenic pathways. Accordingly, we identified the microtubule-associated HPIP, a positive regulator of oncogenic AKT signaling, as a novel MDM2 substrate. MDM2-dependent HPIP degradation occurs in breast cancer cells on its phosphorylation by the estrogen-activated kinase TBK1. Importantly, decreasing Mdm2 gene dosage in mouse mammary epithelial cells potentiates estrogen-dependent AKT activation owing to HPIP stabilization. In addition, we identified HPIP as a novel p53 transcriptional target, and pharmacological inhibition of MDM2 causes p53-dependent increase in HPIP transcription and also prevents HPIP degradation by turning off TBK1 activity. Our data indicate that p53 reactivation through MDM2 inhibition may result in ectopic AKT oncogenic activity by maintaining HPIP protein levels.Cell Death and Differentiation advance online publication, 31 January 2014; doi:10.1038/cdd.2014.2. [less ▲]

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See detailL'articulation des règles fiscales anti-abus générales et spécifiques : essai de clarification
Bourgeois, Marc ULg; Nollet, Aymeric ULg

in Revue Générale du Contentieux Fiscal [=RGCF] (2014), 2014(3-4), 185-187

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See detailHigh resolution saturated hydraulic conductivity logging of friable to poorly indurated borehole cores using air permeability measurements
Rogiers, Bart; Winters, P.; Huysmans, Marijke et al

in Hydrogeology Journal (2014)

Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater flow and contaminant transport in both unsaturated and saturated porous media. This paper investigates ... [more ▼]

Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater flow and contaminant transport in both unsaturated and saturated porous media. This paper investigates the hand-held air permeameter technique for high resolution hydraulic conductivity determination on borehole cores using a spatial resolution of ~0.05 m. We test the suitability of such air permeameter measurements on friable to poorly indurated sediments to improve the spatial prediction of classical laboratory based Ks measurements obtained at a much lower spatial resolution (~2 m). About 368 Ks measurements were made on ~350 m of borehole cores originating from the Campine basin, Northern Belgium, while ~5230 air permeability measurements were performed on the same cores. The heterogeneity in sediments, ranging from sand to clayey sand with distinct clay lenses, resulted in a Ks range of seven orders of magnitude. Cross-validation demonstrated that using air permeameter data as secondary variable and laboratory based Ks measurements as primary variable increased performance from R2 = 0.35 for ordinary kriging (laboratory Ks only) to R2 = 0.61 for co-kriging. Due to the large degree of small-scale variability detected by the air permeameter, the spatial granularity in the predicted laboratory Ks also increases drastically. The separate treatment of Kh and Kv revealed considerable anisotropy in certain lithostratigraphical units, while others where clearly isotropic at the sample scale. Air permeameter measurements on borehole cores provide a cost-effective way to improve spatial predictions of traditional laboratory based Ks. [less ▲]

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See detailAnalysis of the Shrinkage Effect on Mass Transfer During Convective Drying of Sawdust/Sludge Mixtures
Li, Jie ULg; Bennamoun, Lyes; Fraikin, Laurent ULg et al

in Drying Technology (2014), 32

Convective drying of wastewater sludges and sawdust/sludge mixtures was studied. The first part of this work was an experimental study performed in a cross-flow convective dryer using 500 g of wet ... [more ▼]

Convective drying of wastewater sludges and sawdust/sludge mixtures was studied. The first part of this work was an experimental study performed in a cross-flow convective dryer using 500 g of wet material extruded through a disk with circular dies of 12 mm. The results showed that the sawdust addition has a positive impact on the drying process from a mass ratio of 2/8, on a dry basis, with observed drying rates higher than the original sludge. The second part of this work consisted of developing a drying model in order to identify the internal diffusion coefficient and convective mass transfer coefficient from the experimental data. A comparison was made between fitted drying curves, well represented by the Newton’s model, and the analytical solutions of the diffusion equation applied to a finite cylinder. Variations of dimensional characteristics such as the volume and exchange surface of the sample bed were obtained by X-ray tomography. This technique allowed confirm that shrinkage, which is an important phenomenon occurring during sludge and sawdust/mixture drying, must be taken into account. The results showed that both the internal diffusion coefficient and convective mass transfer coefficient were affected by mixing and sawdust addition. The internal diffusion coefficient changed from 7.77×10-9 m2/s for the original sludge to 7.01×10-9 m2/s for the mixed sludge and then increased to 8.35×10-9 m2/s for the mixture of a mass ratio of 4/6. The convective mass transfer coefficient changed from 9.70×10-8 m/s for the original sludge to 8.67×10-8 m/s for the mixed sludge and then increased to 12.09×10-8 m/s for the mixture of a mass ratio of 4/6. These results confirmed that sawdust addition was beneficial to the sludge drying process as the mass transfer efficiency between the air and material increased. Reinforcing the texture of sludge by adding sawdust can increase the drying rate and decrease the drying time, and then the heat energy supply will be reduced significantly. The study also showed that neglecting shrinkage phenomenon resulted in an overestimation for the internal diffusion coefficient for the convective drying of sludges and sawdust/sludge mixtures. [less ▲]

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See detailLe Pacifisme d'Auguste Beernaert. De l'homme d'Etat à l'homme des Etats
Genin, Vincent ULg

in Espace de Libertés : Magazine du Centre d'Action Laïque (2014), 429

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See detailLivre et jeu vidéo. Introduction
Dozo, Björn-Olav ULg; Barnabé, Fanny ULg

in Mémoires du livre / Studies in Book Culture (2014), 5(2),

Introduction au numéro thématique "Livre et jeu vidéo" de la revue Mémoires du livre / Studies in book culture .

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See detailCan we use circulating biomarkers to monitor bone turnover in CKD haemodialysis patients? Hypotheses and facts
DELANAYE, Pierre ULg; Souberbielle, Jean-Claude; Lafage-Proust, Marie-Hélène et al

in Nephrology Dialysis Transplantation (2014), 29(5), 997-1004

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical ... [more ▼]

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical practice and because bone histomorphometry is less available due to the lack of specialized laboratories, we will focus on potential biomarkers used to assess and monitor bone turnover. After briefly reviewing the pathophysiology of bone turnover in CKD and haemodialysis patients, we will focus on the strengths and limitations of the now recommended biomarkers, i.e. parathormone and bone-specific alkaline phosphatase. We will consider the clinical and also the biological aspects of the topic and also insist on the use of these biomarkers for the monitoring, and the follow-up of the turnover in haemodialysis subjects. Finally, we will discuss some of the most promising, but still not recommended, emerging biomarkers. [less ▲]

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See detailPompes à insuline, capteurs et activité physique. Existe t il des recommandations?
RADERMECKER, Régis ULg

in Diabète et Obésité (2014)

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See detailLa radicalité ouvrière en Europe. Acteurs, pratiques, discours
Geuens, Geoffrey ULg; Hamers, Jérémy ULg

in Quaderni : la Revue de la Communication (2014), 84(printemps 2014),

En raison de leur caractère violent et/ou de leur illégalité, certaines luttes ouvrières font l’objet d’un traitement médiatique et politique stéréotypé les maintenant à un niveau que l’on pourrait ... [more ▼]

En raison de leur caractère violent et/ou de leur illégalité, certaines luttes ouvrières font l’objet d’un traitement médiatique et politique stéréotypé les maintenant à un niveau que l’on pourrait qualifier d’infrapolitique (« colère », « coup de sang », etc.). Un terme qualifie, très précisément, jusqu'à l'inflation rhétorique ces actions : « radicalité ». Ce dossier analyse les usages de la notion par divers acteurs (journalistes, juristes, politiques…), les liens entre radicalisation des registres d’action et luttes sociales, ainsi que les déterminants politiques, idéologiques et socio-culturels des discours fixant la frontière entre ce qui, dans une société donnée, relève de l'acceptable et de l'inacceptable. Contributeurs au dossier : G. Geuens et J. Hamers (Université de Liège, LEMME), A. Cavazzini (Groupe de Recherches Matérialistes), M. Jander (Freie Universität Berlin, Hamburger Institut für Sozialforschung) B. Carpenter (Duke University) et F.-W. Korsten (Erasmus University, University of Leiden), G. Cormann (Université de Liège), A. Mattoni et M. Vogiatzoglou (European University Institute). [less ▲]

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See detailA Brief Review of Ultraviolet Auroral Emissions on Giant Planets
Grodent, Denis ULg

in Space Science Reviews (2014)

The morphologies of the ultraviolet auroral emissions on the giant gas planets, Jupiter and Saturn, have conveniently been described with combinations of a restricted number of basic components. Although ... [more ▼]

The morphologies of the ultraviolet auroral emissions on the giant gas planets, Jupiter and Saturn, have conveniently been described with combinations of a restricted number of basic components. Although this simplified view is very handy for a gross depiction of the giant planets’ aurorae, it fails to scrutinize the diversity and the dynamics of the actual features that are regularly observed with the available ultraviolet imagers and spectrographs. In the present review, the typical morphologies of Jupiter and Saturn’s aurorae are represented with an updated and more accurate set of components. The use of sketches, rather than images, makes it possible to compile all these components in a single view and to put aside ultraviolet imaging technical issues that are blurring the emission sources, thus preventing one from disentangling the different auroral signatures. The ionospheric and magnetospheric processes to which these auroral features allude can then be more easily accounted. In addition, the use of components of the same kind for both planets may help to put forward similarities and differences between Jupiter and Saturn. The case of the ice giants Uranus and Neptune is much less compelling since their weak auroral emissions are very poorly documented and one can only speculate about their origin. This review presents a current perspective that will inevitably evolve in the future, especially with upcoming observing campaigns and forthcoming missions like Juno. [less ▲]

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See detailSonographische Diagnostik bei abnorm invasiver Plazenta
Tutschek, Boris; CHANTRAINE, Frédéric ULg; Braun, Thorsten et al

in Der Gynäkologe (2014), 47

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine ... [more ▼]

Abnormally invasive placenta (AIP or “mor- bidly adherent placenta”) significantly con- tributes to maternal morbidity and mortality , potentially causing severe hemorrhage at de- livery. Previous uterine surgery is the main risk factor. It may be speculated that with the rise in Caesarean delivery rates the incidence of AIP will also increase. Prenatal detection of AIP is mandatory to reduce the perinatal morbidity. Obstetrical ultrasound should be used as a screening tool for AIP. There are well known sonographic signs in B-mode, color Doppler and dynamic ultrasound that form the basis for prenatal detection. This review highlights these ultrasound markers and shows clinical examples. [less ▲]

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See detailCoupling X-ray microtomography and macroscopic soil measurements: a method to enhance near saturation functions?
Beckers, Eléonore ULg; Plougonven, Erwan; Gigot, Nicolas et al

in Hydrology and Earth System Sciences (2014), 18

Agricultural management practices influence soil structure, but the characterization of these modifications and consequences are still not completely understood. In this study, we aim at improving water ... [more ▼]

Agricultural management practices influence soil structure, but the characterization of these modifications and consequences are still not completely understood. In this study, we aim at improving water retention and hydraulic conductivity curves using both classical soil techniques and X-ray microtomography in the context of tillage simplification. We show a good match for retention and conductivity functions between macroscopic measurements and microtomographic information. Microtomography highlights the presence of a secondary pore system. Analysis of structural parameters for these pores appears to be significant and offers additional clues for objects differentiation. We show that relatively fast scans supply not only good results, but also enhance near saturation characterization, making microtomography a highly competitive instrument for routine soil characterization. [less ▲]

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See detailComparison of implementation techniques for Galerkin projection between different meshes
Wang, Zifu; Henneron, Thomas; Dular, Patrick ULg et al

in International Journal of Numerical Modeling: Electronic Networks, Devices and Fields (2014), 27(3), 517-526

To solve multiphysics problems, weak coupling of finite element calculations can be carried out: the subproblems of which the physical nature differs are solved separately on their own meshes. In this ... [more ▼]

To solve multiphysics problems, weak coupling of finite element calculations can be carried out: the subproblems of which the physical nature differs are solved separately on their own meshes. In this case, Galerkin projection provides useful tool to ensure the transfer of physical fields between different meshes. In terms of implementation, the Galerkin projection system can be either accurately assembled over the intersection of two meshes or approximately integrated over the target mesh. This paper describes and compares these two implementation techniques for the Galerkin projection. [less ▲]

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See detailGenetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
Gusareva, Elena ULg; Kurey, Irina; Grekov, Igor et al

in Biological Reviews of the Cambridge Philosophical Society (2014), 89(2), 375-405

Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour ... [more ▼]

Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody. [less ▲]

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See detailImplementing Human Rights in Benin: The Case of Inheritance Disputes
Andreetta, Sophie ULg

in Journal of Human Rights Practice (2014)

On 14 June 2004, Benin ratified a new Code on Persons and Family, adapting its previous dual legal system to the requirements of international human rights law. For the purpose of this article, I chose to ... [more ▼]

On 14 June 2004, Benin ratified a new Code on Persons and Family, adapting its previous dual legal system to the requirements of international human rights law. For the purpose of this article, I chose to focus on inheritance conflicts as a back door to questioning the implementation of a law directly inspired by international human rights standards and principles. When it comes to inheritance disputes, are human rights respected in Benin? What are the discourses of the judges, the lawyers, and the notaries regarding this new Code? How is it implemented and what are the obstacles to it? Combining both qualitative interviews with family members and participant observation in the courtrooms, I compiled a series of case studies, supplemented by interviews with judicial officials. These sets of data allowed me to grasp how laws are enforced and interpreted, and how citizens deal with their families and with the justice system. [less ▲]

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See detailRénover ou réformer la fiscalité du logement en Wallonie
Xhignesse, Guillaume ULg

in Revue Générale de Fiscalité [= RFG] (2014)

Cette contribution a pour objectif de stimuler la discussion relative à la réforme de la fiscalité du logement en Belgique, et plus particulièrement en Wallonie. Nous y évoquons quelques enjeux d'une ... [more ▼]

Cette contribution a pour objectif de stimuler la discussion relative à la réforme de la fiscalité du logement en Belgique, et plus particulièrement en Wallonie. Nous y évoquons quelques enjeux d'une telle réforme et nous proposons diverses pistes de réflexions. [less ▲]

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See detailProjected inhibition of platelet aggregation with ticagrelor twice daily vs. clopidogrel once daily based on patient adherence data (the TWICE project)
Vrijens, Bernard ULg; Claeys, M.J.; LEGRAND, Victor ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 746-755

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained ... [more ▼]

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained when doses are delayed or missed. We compared the estimated inhibition of platelet aggregation (eIPA) for ticagrelor twice daily and clopidogrel once daily, based on their pharmacokinetic/ pharmacodynamic relationships and patient dosing history data. Methods Drug dosing histories of 5014 patients prescribed cardiovascular medications (primarily antihypertensive medicines) were extracted from an electronically compiled dosing history database. eIPA levels were simulated for 677 twice daily and 677 once daily dosing histories over a 30 day period, based on published onset/offset models for ticagrelor and clopidogrel IPA characteristics. Results While many patients treated twice daily missed at least one dose in 30 days, only 25.7% missed two consecutive doses. By comparison, 46.8% of patients treated once daily missed at least one dose. Simulations based on patient adherence over time showed that the average mean eIPA for ticagrelor twice daily remained significantly higher than for clopidogrel once daily (81.1% vs. 55.0%, P < 0.001). Ticagrelor twice daily patients had an eIPA below 10% for 0.20% of the 30 day period compared with 2.05% for clopidogrel once daily (P = 0.0001). Conclusions The projected level of platelet inhibition remained higher for ticagrelor twice daily than clopidogrel once daily, mainly due to the higher eIPA level achieved with ticagrelor and the relatively low likelihood of missing two consecutive twice daily doses. This modelling and simulation study suggests a therapeutic benefit of ticagrelor over clopidogrel when taking into account the most common dosing omissions. © 2013 The British Pharmacological Society. [less ▲]

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See detailLa Fête du 14 juillet à Liège vue par le consul de France Léon Labbé (1919-1930). Une célébration sous surveillance
Genin, Vincent ULg

in Bulletin de la Société Royale Le Vieux-Liège (2014), 344

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See detailSelf-medication in persistent rhinitis: overuse of decongestants in half of the patients.
Mehuys, Els; Gevaert, Philippe; Brusselle, Guy et al

in Journal of Allergy and Clinical Immunology - In Practice (2014), 2(3), 313-319

BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self ... [more ▼]

BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self-medicating persistent rhinitis and to determine the prevalence of and risk factors for intranasal decongestant overuse within this population. METHODS: A cross-sectional observational study of individuals self-medicating persistent rhinitis (defined according to the Allergic Rhinitis and its Impact on Asthma guidelines). Participants (n = 895) completed a self-administered questionnaire to assess current symptoms, rhinitis medication, and previous physician diagnosis. Intranasal decongestant overuse was defined as daily use for at least 1 year. RESULTS: The vast majority of subjects (95%) had moderate-to-severe rhinitis. Nasal congestion was the predominant symptom (median visual analog scale, 6.6 cm; interquartile range, 3.4 cm). Sixty-five percent had had their current nasal problems for more than 5 years. Approximately 80% had a physician diagnosis (mainly allergic rhinitis or rhinosinusitis). The prevalence of intranasal decongestant overuse was high (49%), despite the fact that most of the patients (80%) were educated about the limit on duration of use. Use of intranasal glucocorticosteroids was inversely related to being an overuser (odds ratio 0.24 [95% CI, 0.17-0.35]). The risk of intranasal decongestant overuse also was reduced by use of other medications (oral H1 antihistamines and decongestants), use of nasal saline solution, and more symptoms of itchy and/or runny eyes or colored mucus. Risk was increased by a more severely blocked nose, longer duration of symptoms, the presence of sleep disturbance, higher body mass index, and previous advice to limit the duration of intranasal decongestant use. CONCLUSION: Half of the individuals self-medicating persistent rhinitis overused intranasal decongestants, despite the fact that they were educated about the limit on duration of use. [less ▲]

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See detailResilience to Flooding - Draft Building Code
Clarkson, John; Sullican, David; Braun, Kenton et al

in PIANC Yearbook 2013 (2014)

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See detailLe Musée de la Vie wallonne, indissociablement lié aux dialectologues liégeois
Frankinet, Baptiste ULg

in Culture, le Magazine Culturel de l'Université de Liège (2014)

Au-delà d’un travail pointu de description et d’explication, les dialectologues liégeois ont toujours veillé à préserver les traces d’un patrimoine immatériel menacé de disparition. Selon eux, ce ... [more ▼]

Au-delà d’un travail pointu de description et d’explication, les dialectologues liégeois ont toujours veillé à préserver les traces d’un patrimoine immatériel menacé de disparition. Selon eux, ce patrimoine dépassait le cadre strictement linguistique ou lexical pour épouser les formes d’un ensemble bien plus vaste : la vie wallonne tout entière. Impossible pour eux d’étudier un dialecte sans veiller à garder les usages ou les objets qu’il nomme, ni le souvenir des gens qui le parlent. Ainsi, en plus d’être des observateurs attentifs à leurs propres parlers, ils devinrent les premiers conservateurs de leur région. [less ▲]

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See detailPhysical forcing and physical/biochemical variability of the Mediterranean Sea: A review of unresolved issues and directions for future research
Malanotte-Rizzoli et al, Paula; Artale, V; Borzelli-Eusebi, G et al

in Ocean Science (2014), 10(3),

This paper is the outcome of a workshop held in Rome in November 2011 on the occasion of the 25th anniversary of the POEM (Physical Oceanography of the Eastern Mediterranean) program. In the workshop ... [more ▼]

This paper is the outcome of a workshop held in Rome in November 2011 on the occasion of the 25th anniversary of the POEM (Physical Oceanography of the Eastern Mediterranean) program. In the workshop discussions, a number of unresolved issues were identified for the physical and biogeochemical properties of the Mediterranean Sea as a whole, i.e., comprising the Western and Eastern sub-basins. Over the successive two years, the related ideas were discussed among the group of scientists who participated in the workshop and who have contributed to the writing of this paper. Three major topics were identified, each of them being the object of a section divided into a number of different sub-sections, each addressing a specific physical, chemical or biological issue: 1. Assessment of basin-wide physical/biochemical properties, of their variability and interactions. 2. Relative importance of external forcing functions (wind stress, heat/moisture fluxes, forcing through straits) vs. internal variability. 3. Shelf/deep sea interactions and exchanges of physical/biogeochemical properties and how they affect the sub-basin circulation and property distribution. Furthermore, a number of unresolved scientific/methodological issues were also identified and are reported in each sub-section after a short discussion of the present knowledge. They represent the collegial consensus of the scientists contributing to the paper. Naturally, the unresolved issues presented here constitute the choice of the authors and therefore they may not be exhaustive and/or complete. The overall goal is to stimulate a broader interdisciplinary discussion among the scientists of the Mediterranean oceanographic community, leading to enhanced collaborative efforts and exciting future discoveries [less ▲]

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See detailVitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiency
Djennane, M; Lebbah, S; Roux, C et al

in Osteoporosis International (2014), 25(5), 1493-502

Summary There are no published data on the vitamin D status of children living in North Africa. In 435 healthy Algerian children 5–15 years old, we found that vitamin D insufficiency (serum 25 ... [more ▼]

Summary There are no published data on the vitamin D status of children living in North Africa. In 435 healthy Algerian children 5–15 years old, we found that vitamin D insufficiency (serum 25-hydroxyvitamin D (25OHD) <50 nmol/L) was frequent, especially in winter. Low vitamin D status was associated with increased parathyroid hormone (PTH) and leg deformation Introduction As there are no published data on the vitamin D status of children living in North Africa, we evaluated the 25OHD concentration of healthy Algerian children at the end of summer and at the end of winter. As secondary objectives, we studied the various determinants of vitamin D status and the PTH-25OHD relationship in these subjects. Methods Four hundred thirty-five children 5–15 years old were examined and had a blood sample in September 2010. Of them, 408 were sampled again in March 2011. Results Median 25OHD concentration in the whole group was 71.4 nmol/L in September and 52.9 nmol/L in March. In September, 58.4, 29.9, and 8.1 % had a 25OHD concentration below 75, 50, and 30 nmol/L respectively. In March, these percentages increased to 65.2, 41.4, and 17.4 % for the 75, 50, and 30 nmol/L threshold, respectively. In multivariate analysis, older age, darker skin phototype, low daily vitamin D and calcium intake, poor socioeconomic status, and short daily sun exposure remained significantly associated with a 25OHD <50 nmol/L at both visits. In 72 (16.6 %) children, genu varum/valgum was present. Compared to the 363 children without leg deformation, they presented more frequently with the risk factors of vitamin D insufficiency. They also had lower 25OHD concentrations and higher PTH and tALP. Serum PTH and 25OHD concentrations were negatively and significantly correlated (r=−0.43; p<0.001) without a 25OHD threshold above which PTH does not decrease anymore. Conclusion Despite a sunny environment, vitamin D insufficiency is frequent in healthy Algerian children. [less ▲]

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See detailResektion der Plazentahaftstelle bei pathologischer Plazentainvasion
CHANTRAINE, Frédéric ULg; PETIT, Philippe ULg; Langhoff-Roos, Jens

in Der Gynäkologe (2014), 47

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity ... [more ▼]

Abnormally invasive placenta (AIP) is a rare condition with an increasing incidence. Severe cases, such as placenta percreta, can cause massive peripartal bleeding linked to an elevated maternal morbidity and even mortality. Prenatal AIP screening using ultra- sound allows referral to a specialized centre in suspected cases in order to optimize the chances for mother and child. Caesarean hys- terectomy or placenta in situ methods are the currently known and recommended management options. This article describes the techniques of elective resection of the placental bed including AIP which allow conserving the uterus and preserving fertility. Furthermore, it seems that morbidity of this technique is lower when compared to the standard treatment options. Whether this is due to a selection of less severe AIP cases for resection or really represents a lower complication rate in cases of resection has to be demonstrated by further prospective studies. [less ▲]

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See detailLutter contre le fléau des médicaments contrefaits
Rudaz, Serge; Hubert, Philippe ULg

in Spectra Analyse (2014), 298

Editorial

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See detailMicroRNA Targeting of CoREST controls polarization of migrating cortical neurons
Volvert; Prévot, Pierre-Paul; Close, Pierre ULg et al

in Cell Reports (2014), 7(4), 1168-83

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See detailDes performances de production laitière et de reproduction élevées sont compatibles. Le management en est la clé.
Chapaux, Philippe; Glorieux, Géry; Hanzen, Christian ULg

in Veterinaria (Bruxelles) : Bulletin d’Information de l’Union Syndicale Vétérinaire Belge (2014)

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See detailMéthodes chromatographiques génériques de criblage pour lutter contre les médicaments de qualité inférieure
Habyalimana, Védaste; Kalenda Tshilombo, Nicodème; Dispas, Amandine ULg et al

in Spectra Analyse (2014), 43

Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class ... [more ▼]

Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class using an innovative strategy based on design of experiments followed in some cases by independent component analysis and calculation of design space. Once validated via the classical total error measurement approach, these methods were applied to quantify antimalarial, non-steroidal anti-inflammatory and antibiotic medicines. Alarming results regarding the dosage of these drugs widely used by people confirm the need to fight against this scourge. [less ▲]

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See detailHeterochrony in a complex world: disentangling environmental processes of facultative paedomorphosis in an amphibian
Denoël, Mathieu ULg; Ficetola, Gentile Francesco

in Journal of Animal Ecology (2014), 83(3), 606-615

1. Heterochrony, the change in the rate or timing of development between ancestors and their descendants, plays a major role in evolution. When heterochrony produces polymorphisms, it offers the ... [more ▼]

1. Heterochrony, the change in the rate or timing of development between ancestors and their descendants, plays a major role in evolution. When heterochrony produces polymorphisms, it offers the possibility to test hypotheses that could explain its success across environments. Amphibians are particularly suitable to exploring these questions because they express complex life cycles (i.e. metamorphosis) that have been disrupted by heterochronic processes (paedomorphosis: retention of larval traits in adults). The large phenotypic variation across populations suggests that more complex processes than expected are operating, but they remain to be investigated through multivariate analyses over a large range of natural populations across time. 2. In this study we compared the likelihood of multiple potential environmental determinants of heterochrony. We gathered data on the proportion of paedomorphic and metamorphic palmate newts (Lissotriton helveticus) across more than 150 populations during 10 years, and used an information-theoretic approach to compare the support of multiple potential processes. 3. Six environmental processes jointly explained the proportion of paedomorphs in populations: predation, water availability, dispersal limitation, aquatic breathing, terrestrial habitat suitability, and anti-predator refuges. Analyses of variation across space and time supported models based on the advantage of paedomorphosis in favourable aquatic habitats. 4. Paedomorphs were favoured in deep ponds, in conditions favourable to aquatic breathing (high oxygen content), with lack of fish, and surrounded by suitable terrestrial habitat. Metamorphs were favoured by banks allowing easy dispersal. 5. These results indicate that heterochrony relies on complex processes involving multiple ecological variables and exemplifies why heterochronic patterns occur in contrasted environments. On the other hand, the fast selection of alternative morphs shows that metamorphosis and paedomorphosis developmental modes could be easily disrupted in natural populations. [less ▲]

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See detailImplementation of a non-orthogonal constitutive model for the finite element simulation of textile composite draping
Pierce, Robert S; Falzon, Brian G; Thompson, Mark C et al

in Applied Mechanics and Materials (2014), 553

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This ... [more ▼]

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This paper focuses on the continuum-based, finite element modelling of textile composites as they deform during the draping process. A non-orthogonal constitutive model tracks yarn orientations within a material subroutine developed for Abaqus/Explicit, resulting in the realistic determination of fabric shearing and material draw-in. Supplementary material characterisation was experimentally performed in order to define the tensile and non-linear shear behaviour accurately. The validity of the finite element model has been studied through comparison with similar research in the field and the experimental lay-up of carbon fibre textile reinforcement over a tool with double curvature geometry, showing good agreement. [less ▲]

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See detailTransiting hot Jupiters from WASP-South, Euler and TRAPPIST: WASP-95b to WASP-101b
Hellier, Coel; Anderson, D. R.; Collier Cameron, A. et al

in Monthly Notices of the Royal Astronomical Society (2014)

We report the discovery of the transiting exoplanets WASP-95b, WASP-96b, WASP-97b, WASP-98b, WASP-99b, WASP-100b and WASP-101b. All are hot Jupiters with orbital periods in the range 2.1-5.7 d, masses of ... [more ▼]

We report the discovery of the transiting exoplanets WASP-95b, WASP-96b, WASP-97b, WASP-98b, WASP-99b, WASP-100b and WASP-101b. All are hot Jupiters with orbital periods in the range 2.1-5.7 d, masses of 0.5-2.8 MJup and radii of 1.1-1.4 RJup. The orbits of all the planets are compatible with zero eccentricity. WASP-99b produces the shallowest transit yet found by WASP-South, at 0.4 per cent. The host stars are of spectral type F2-G8. Five have metallicities of [Fe/H] from -0.03 to +0.23, while WASP-98 has a metallicity of -0.60, exceptionally low for a star with a transiting exoplanet. Five of the host stars are brighter than V = 10.8, which significantly extends the number of bright transiting systems available for follow-up studies. WASP-95 shows a possible rotational modulation at a period of 20.7 d. We discuss the completeness of WASP survey techniques by comparing to the HATnet project. [less ▲]

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See detailAngles corniculaires et de demi-cercle chez Euclide
Bair, Jacques ULg; Henry, Valérie ULg

in Hors Série Tangente (2014), 53

Les angles datent de l’Antiquité : ils sont présents dans le célèbre ouvrage "Les Éléments" d’Euclide. En partant des "Commentaires" de Proclus, nous présentons la façon dont Euclide introduisait le ... [more ▼]

Les angles datent de l’Antiquité : ils sont présents dans le célèbre ouvrage "Les Éléments" d’Euclide. En partant des "Commentaires" de Proclus, nous présentons la façon dont Euclide introduisait le concept d'angle et sa distinction entre les angles rectilignes et mixtilignes. Les cas des angles corniculaires et de demi-cercle sont spécialement traités. [less ▲]

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See detailA new analysis of quasar polarization alignments
Pelgrims, Vincent ULg; Cudell, Jean-René ULg

in Monthly Notices of the Royal Astronomical Society (2014), 442(1), 1239-1248

We propose a new method to analyse the alignment of optical polarization vectors from quasars. This method leads to a definition of intrinsic preferred axes and to a determination of the probability that ... [more ▼]

We propose a new method to analyse the alignment of optical polarization vectors from quasars. This method leads to a definition of intrinsic preferred axes and to a determination of the probability that the distribution of polarization directions is random. This probability is found to be as low as 0,003 percent for one of the region of redshift. [less ▲]

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See detailShewhart Control Charts for Monitoring Reliability with Weibull Lifetimes
Faraz, Alireza ULg; Saniga, Erwin; Heuchenne, Cédric ULg

in Quality and Reliability Engineering International (2014)

In this paper, we present Shewhart type Z ̅ and S2 control charts for monitoring individual or joint shifts in the scale and shape parameters of a Weibull distributed process. The advantage of this method ... [more ▼]

In this paper, we present Shewhart type Z ̅ and S2 control charts for monitoring individual or joint shifts in the scale and shape parameters of a Weibull distributed process. The advantage of this method is its ease of use and flexibility for the case where the process distribution is Weibull, although the method can be applied to any distribution. We illustrate the performance of our method through simulation and the application through the use of an actual data set. Our results indicate that Z ̅ and S2 control charts perform well in detecting shifts in the scale and shape parameters. We also provide a guide that would enable a user to interpret out-of-control signals. [less ▲]

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See detailX-ray microtomography: A porosity-based thresholding method to improve soil pore network characterization?
Beckers, Eléonore ULg; Plougonven, Erwan ULg; Roisin, Christian et al

in Geoderma (2014), 219-220

X-ray microtomography, through quantification of soil structure at the microscale, could greatly facilitate the current understanding of soil hydrodynamic behaviour. However, binarisation method and ... [more ▼]

X-ray microtomography, through quantification of soil structure at the microscale, could greatly facilitate the current understanding of soil hydrodynamic behaviour. However, binarisation method and processing choices are subjective and can have a strong impact on results and conclusions. In this study, we test a new method based on the porosity detectable by X-ray microtomography, while validation is achieved through comparison of soil microtomogram information with soil physical measurements. These measurements consist of water retention and unsaturated hydraulic conductivity using two different soil populations with only structural differences. To assess the porosity-based method performances, we compare it to four other methods, namely the global method of Otsu and three recent soil-dedicated local methods. The robustness of the porosity-based method is also tested in regard to different pre-processing procedures. In this paper we demonstrate that soil segmentation through a porosity-based method is an interesting issue. Indeed, it is less demanding in terms of time and computational requirements than its alternatives, and combines robustness and performances broadly comparable with the recent local methods. [less ▲]

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See detailAnalysis of transient scattering problems using a discontinuous Galerkin method: application to the shielding effectiveness of enclosures with heterogeneous walls
Boubekeur, Mohamed; Kameni, Abelin; Pichon, Lionel et al

in International Journal of Numerical Modelling: Electronic Networks, Devices and Fields (2014), 27(3), 626-635

In this paper, different formulations of Maxwell equations are combined for computing the shielding effectiveness of enclosures made from heterogeneous periodic materials. The validity of the homogenized ... [more ▼]

In this paper, different formulations of Maxwell equations are combined for computing the shielding effectiveness of enclosures made from heterogeneous periodic materials. The validity of the homogenized parameters given by Maxwell-Garnett rules in the frequency domain are tested in the time domain using a nodal discontinuous Galerkin method, which uses an interface condition based on analytical solution in the frequency domain to replace a conductive sheet. This interface condition allows to avoid meshing the thin sheet, thus reducing the computational cost. Results of scattering by composite enclosures are presented in the frequency domain thanks to a Fast Fourier Transform. [less ▲]

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See detailEditorial
Cavazzini, Andrea ULg

in Cahiers du GRM (2014), 5

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See detailInfluence of a commercial monoacylglycerol on the crystallization mechanism of palm oil as compared to its pure constituents
Verstringe, Stefanie; Danthine, Sabine ULg; Blecker, Christophe ULg et al

in Food Research International (2014), 62

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main ... [more ▼]

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main constituents of Myverol, monopalmitin and monostearin. The MAGs were added to PO in concentrations up to 8% and the blends were studied using different techniques (differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarized light microscopy (PLM)). The DSC crystallization profiles revealed an earlier onset of crystallization along with extra crystallization peaks when MAGs were added to PO. Combined with X-ray results, it could be concluded that the crystallization process of the blends is initiated by the MAGs crystallizing in the α form and then transforming to sub-α. The effect on the non-isothermal crystallization of the PO TAGs is confined to an earlier onset of crystallization, probably through a template effect, and an effect on the crystal structure coarseness. [less ▲]

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See detailInfluence of a commercial monoacylglycerol on the crystallization mechanism of palm oil as compared to its pure constituents
Verstringe, Stefanie; Danthine, Sabine ULg; Blecker, Christophe ULg et al

in Food Research International (2014), 62

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main ... [more ▼]

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main constituents of Myverol, monopalmitin and monostearin. The MAGs were added to PO in concentrations up to 8% and the blends were studied using different techniques (differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarized light microscopy (PLM)). The DSC crystallization profiles revealed an earlier onset of crystallization along with extra crystallization peaks when MAGs were added to PO. Combined with X-ray results, it could be concluded that the crystallization process of the blends is initiated by the MAGs crystallizing in the α form and then transforming to sub-α. The effect on the non-isothermal crystallization of the PO TAGs is confined to an earlier onset of crystallization, probably through a template effect, and an effect on the crystal structure coarseness. [less ▲]

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See detailLong-wave infrared digital holographic interferometry with diffuser or point source illuminations for measuring deformations of aspheric mirrors
Vandenrijt, Jean-François ULg; Thizy, Cédric ULg; Queeckers, Patrick et al

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (2014), 53(11), 112309

Long-wave infrared digital holographic interferometry with CO2 laser and microbolometer arrays has been developed for testing the large deformations of space reflectors. The setup considered is a ... [more ▼]

Long-wave infrared digital holographic interferometry with CO2 laser and microbolometer arrays has been developed for testing the large deformations of space reflectors. The setup considered is a Mach–Zehnder, associated to the digital holography reconstruction of the wavefront in the inline configuration with phase shifting. Two possibilities exist for illuminating the tested reflector: either with a point source (similarly to classical interferometry) or an extended source (with a diffuser). This paper presents the development of a modular setup which allows comparing both in the case of a parabolic mirror [less ▲]

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See detailOverlap syndrome consisting of PSC-AIH with concomitant presence of a membranous glomerulonephritis and ulcerative colitis
Warling, O; BOVY, Christophe ULg; COIMBRA MARQUES, Carla ULg et al

in World Journal of Gastroenterology (2014), 20(16), 4811-4816

Abstract The association of primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) is known as an overlap syndrome (OS). OS can also be described in the setting of concomitant presence of AIH ... [more ▼]

Abstract The association of primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) is known as an overlap syndrome (OS). OS can also be described in the setting of concomitant presence of AIH and PSC. These diseases can in some cases be associated with ulcerative colitis. In this case report we describe, to our knowledge, the first case in the literature of a young Caucasian male suffering from ulcerative colitis and an overlap syndrome consisting of an association between PSC-AIH, with the concomitant presence of a membranous glomerulonephritis. [less ▲]

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See detailBrown rust disease control in winter wheat: II. Exploring the optimization of fungicide sprays through a decision support system
El Jarroudi, Moussa ULg; kOUADIO, Louis; Giraud, Frédéric et al

in Environmental Science & Pollution Research (2014), 21(4), 4809-4818

A decision support system (DSS) involving an approach for predicting wheat leaf rust (WLR) infection and progress based on night weather variables (i.e., air temperature, relative humidity, and rainfall ... [more ▼]

A decision support system (DSS) involving an approach for predicting wheat leaf rust (WLR) infection and progress based on night weather variables (i.e., air temperature, relative humidity, and rainfall) and a mechanistic model for leaf emergence and development simulation (i.e., PROCULTURE) was tested in order to schedule fungicide time spray for controlling leaf rust progress in wheat fields. Experiments including a single fungicide treatment based upon the DSS along with double and triple treatment were carried out over the 2007–2009 cropping seasons in four representative Luxembourgish wheat field locations. The study showed that the WLR occurrences and severities differed according to the site, cultivar, and year. We also found out that the single fungicide treatment based on the DSS allowed a good protection of the three upper leaves of susceptible cultivars in fields with predominant WLR occurrences. The harvested grain yield was not significantly different from that of the double and triple fungicide-treated plots (P < 0.05). Such results could serve as basis or be coupled to cost-effective and environmentally friendly crop management systems in operational context. [less ▲]

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See detailPoly(methyl methacrylate)/graphene oxide nanocomposites by a precipitation polymerization process and their dielectric and rheological characterization
Thomassin, Jean-Michel ULg; Trifkovic, Milana; Alkarmo, Walid et al

in Macromolecules (2014), 47(6), 2149-2155

We report a method for achieving controlled dispersion of graphene oxide (GO) in poly(methyl methacrylate) (PMMA) via the precipitation polymerization process in a water/ methanol mixture. GO acts as a ... [more ▼]

We report a method for achieving controlled dispersion of graphene oxide (GO) in poly(methyl methacrylate) (PMMA) via the precipitation polymerization process in a water/ methanol mixture. GO acts as a surfactant and adsorbs on the interface between polymerized PMMA particles and solvent mixture. Scanning electron and transmission electron microscopy confirmed that the precipitate consists of polymer particles (<1 μm) surrounded by the GO sheets. Compression molding of the precipitate yields a polymer nanocomposite with the GO organized into a regularly spaced 3D network which percolates at 0.2 wt % GO. Simple thermal reduction of the GO sheets dispersed in PMMA at relatively low temperature (210 °C) achieved electrical conductivity higher than 10−2 S/m at 0.4 wt % of GO. Parallel dielectric and rheological characterization demonstrated that the thermal reduction is a quite fast process without significant degradation of the polymer. The study should open up new opportunities in the design of GO-based polymer nanocomposites. [less ▲]

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See detailAltered Desferrioxamine-mediated Iron Utilization is a Common Trait of bald Mutants of Streptomyces coelicolor
Lambert, Stéphany ULg; Traxler, Matthew F; Craig, Matthias et al

in Metallomics (2014)

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See detailLess invasive surgical procedures using narrow diameter implants: a prospective study in 20 consecutive patients.
LAMBERT, France ULg; LECLOUX, Geoffrey ULg; GRENADE, Charlotte ULg et al

in Journal of Oral Implantology (The) (2014)

Narrow diameter implants (NDIs) are increasingly produced and used in implant dentistry especially since the introduction of new and more resistant materials. The objective of the present study was to ... [more ▼]

Narrow diameter implants (NDIs) are increasingly produced and used in implant dentistry especially since the introduction of new and more resistant materials. The objective of the present study was to evaluate the clinical performance of NDIs (3.3 mm) placed in thin alveolar crests. Methods: Twenty consecutive patients needing implant-supported fixed partial dentures and presenting an alveolar thickness ≤ 6 mm were treated with one or several NDIs. The surgical protocol was chosen according to the clinical situation: °1 flapless; °2 mini-cervical flap; 3° wide flap; 4° wide flap + guided bone regeneration (GBR). Implants were immediately loaded if the primary stability was higher than 20 Ncm. Implant survival and success, prosthodontic success rates and patient-centered outcomes were evaluated after a follow-up period of 1 year. Results: A total of 39 implants were placed in 20 patients, 12 and 27 implants in the anterior regions and in the posterior mandible, respectively. All implants but one reached an insertion torque higher than 20 Ncm and were loaded within 48 hours. The implant survival and success rates both reached 94.7 %. The need for GBR was avoided in 60 % of the implant sites. The mean peri-implant bone remodeling after a follow-up period of 1 year was -0.35 mm at the implant level. Peri-implant bone remodeling was higher in the posterior region, when the alveolar crest was thinner than 4 mm and GBR was required in addition.Conclusion: The use of NDIs to restore partial edentation in sites with limited horizontal bone thickness seems to be an effective treatment option that prevented GBR in the majority of the present cases. Immediate provisionalization of NDIs does not seem to impair the results. [less ▲]

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See detailStochastic exposure to sub-lethal high temperature enhances exopolysaccharides (EPS) excretion and improves Bifidobacterium bifidum cell survival to freeze-drying
Nguyen, Huu Thanh ULg; Razafindralambo, Hary; Blecker, Christophe ULg et al

in Biochemical Engineering Journal (2014), 88

Exposure of microbial cells to sub-lethal stresses is known to increase cell robustness. In this work, a two-compartment bioreactor in which microbial cells are stochastically exposed to sub-lethal ... [more ▼]

Exposure of microbial cells to sub-lethal stresses is known to increase cell robustness. In this work, a two-compartment bioreactor in which microbial cells are stochastically exposed to sub-lethal temperature stresses has been used in order to investigate the response of the stress sensitive Bifidobacterium bifidum THT 0101 to downstream processing operations. A stochastic model validated by residence time distribution experiments has shown that in the heat-shock configuration, a two-compartment bioreactor (TCB) allows the exposure of microbial cells to sub-lethal temperature of 42°C for a duration comprised between 100 and 300 seconds. This exposure resulted in a significant increase of cell resistance to freeze-drying by comparison with cells cultivated in conventional bioreactors or in the TCB in the cold shock mode (CS-TCB). The mechanism behind this robustness seems to be related with the coating of microbial cells with exopolysaccharide (EPS), as assessed by the change of the zeta potential and the presence of higher EPS concentration after heat shock. Conditioning of Bifidobacteria on the basis of the heat shock technique is interesting from the practical and economical point of view since this strategy can be directly implemented in the bioreactor during stationary phase preceding cell recovery and freeze-drying [less ▲]

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See detailDavid Knoke, Economic networks
Dufays, Frédéric ULg

in Lectures (2014)

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See detailElaboration of drug nanocarriers based on a glucosamine labeled amphiphilic polymer
Boyère, Cédric; Duhem, N; Debuigne, Antoine ULg et al

in Polymer Chemistry (2014), 5(8), 3030-3037

A new functional polymer micelle with high loading efficiency of a poorly soluble drug was made of biocompatible and/or biosourced compounds, i.e. cholesterol-poly(ethylene glycol)-glucosamine (Chol-PEG ... [more ▼]

A new functional polymer micelle with high loading efficiency of a poorly soluble drug was made of biocompatible and/or biosourced compounds, i.e. cholesterol-poly(ethylene glycol)-glucosamine (Chol-PEG-GlcNH2). A synthesis strategy combining enzymatic and metal-free click chemistry was developed in order to meet the increasingly stringent requirements of biomedical applications. After the self-assembly of the Chol-PEG-GlcNH2 amphiphilic polymer in water, the presence of glucosamine at the micelle surface confers an active targeting moiety to the nanocarriers whereas protonation of the peripheral primary amine delay their aggregation. The complete characterization of this novel functional amphiphilic bioconjugate is presented as well as its aqueous solution behaviour and encapsulation efficiency using ketoconazole as a model hydrophobic drug. [less ▲]

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See detail(Co)Polymerization of vinyl levulinate by cobalt-mediated radical polymerization and functionalization by ketoxime click chemistry
Allaoua, Imène; Eleuterio, Beatriz; Obadia, Mona M. et al

in Polymer Chemistry (2014), 5(8), 2973-2979

Vinyl levulinate is synthesized from levulinic acid by palladium-catalyzed vinyl exchange and is characterized by NMR and ESI-HRMS techniques. Homopolymerization of vinyl levulinate and random ... [more ▼]

Vinyl levulinate is synthesized from levulinic acid by palladium-catalyzed vinyl exchange and is characterized by NMR and ESI-HRMS techniques. Homopolymerization of vinyl levulinate and random copolymerization with vinyl acetate by cobalt-mediated radical polymerization affords well-defined ketone functionalized poly(vinyl ester)s. The impact of temperature, solvent and theoretical degree of polymerization on monomer conversion and control of the polymerization is studied by 1H NMR and size exclusion chromatography techniques. The ketoxime conjugation of O-benzylhydroxylamine with the pendant ketone functionality of poly(vinyl levulinate-co-vinyl acetate) is demonstrated. [less ▲]

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See detailPreparation of polyaniline-modified local clay and study of its sorption capacity
Benhebal, Hadj; Chaid, Messaoud; Léonard, Angélique ULg et al

in Journal of Nanostructure in Chemistry (2014), 4(98), 6

Clay minerals are frequently used in adsorption processes with aqueous solution; it was found that the adsorption properties of clays change when the samples are modified. In this context, polyaniline ... [more ▼]

Clay minerals are frequently used in adsorption processes with aqueous solution; it was found that the adsorption properties of clays change when the samples are modified. In this context, polyaniline-modified clay nanocomposite (at 10 %) was prepared by in situ polymerization processes. The structural and morphological characteristics of the synthesized material are systematically examined by X-ray diffraction, scanning electron microscopy, thermo-gravimetry, differential scanning calorimetry and infrared spectroscopy techniques. The adsorption property of the modified clay was evaluated for the removal of a reactive dye (methylene blue) from aqueous solution at room temperature (25 C) via batch adsorption. [less ▲]

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See detailAprès le Communisme
Florence, Eric ULg

in Vie des Idées (La) (2014)

Souvent traités séparément, les cas chinois et européens de l’Est sont abordés conjointement dans un ouvrage interdisciplinaire consacré aux institutions politiques et sociales, aux transformations socio ... [more ▼]

Souvent traités séparément, les cas chinois et européens de l’Est sont abordés conjointement dans un ouvrage interdisciplinaire consacré aux institutions politiques et sociales, aux transformations socio-économiques et aux relations entre État et société. L’angle d’approche tend à présenter l’action de l’État-Parti en Chine sous un jour favorable. [less ▲]

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See detailApplication of isotopic tracers as a tool for understanding hydrodynamic behavior of the highly exploited Diass aquifer system (Senegal)
Madioune, Diakher Hélène; Faye, Serigne; Orban, Philippe ULg et al

in Journal of Hydrology (2014), 511

The Diass horst aquifer system located 50 km east of Dakar (Senegal) is exploited in two main aquifers covered by a sandy superficial aquifer: the confined/unconfined Palaeocene karstic limestone and the ... [more ▼]

The Diass horst aquifer system located 50 km east of Dakar (Senegal) is exploited in two main aquifers covered by a sandy superficial aquifer: the confined/unconfined Palaeocene karstic limestone and the confined Maastrichtian sandstone aquifer underneath. This system has experienced intensive groundwater abstraction during the last 50 years to supply increasing water demand, agricultural and industrial needs. The high abstraction rate from 1989 to 2009 (about 109,000 m3/d) has caused a continuous groundwater level decline (up to 30 m), a modification of the groundwater flow and salinization in parts of the aquifers. The objective of the study is to improve our understanding of the system functioning with regards to high pumping, identify the geochemical reactions that take place in the system, infer origin and timing of recharge by using mainly stable (δ18O, δ2H, 13C) and radioactive (3H and 14C) isotopes. Water types defined in the Piper diagram vary in order of abundance from Ca–HCO3 (65%), Ca/Na–Cl (20%), Na–HCO3 (3%) and Na–Cl (12%). Values of δ18O and δ2H for the superficial aquifer range between −5.8 and −4.2‰ and between −42 and −31‰, respectively. For the Palaeocene aquifer they range from −5.8 to −5.0‰ and from −38 to −31‰, respectively; values in the Maastrichtian aquifer are between −5.9 and −4.3‰ for δ18O and −38 to −26‰ for δ2H. Plotted against the conventional δ18O vs δ2H diagram, data from the upper aquifer exhibit a dispersed distribution with respect to isotopic fractionation while those of the Palaeocene and Maastrichtian aquifers are aligned parallel and slightly below/or on the Global Meteoric Water Line (GMWL) evidencing ancient waters which had evaporated during infiltration. The low tritium (generally <0.7 TU) and 14C (0.7–57.2 pmc) contents indicate predominance of older water being recharged during the Pleistocene and Holocene periods. However, few boreholes which exhibit high tritium (1.2–4.3 TU) and 14C (65.7–70.8 pmc) values indicate some mixture with recent water likely through faulting and vertical drainage from the upper to deeper aquifers as well as lateral flow along flow paths to the piezometric depressions created by pumping. [less ▲]

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See detailLe TAT de Adolf Eichmann
Peralta, Alberto; Kramer, Richard; Stassart, Martine ULg

in Szondiana (2014), 33(Décembre 2013), 8-45

Under consideration of three major personality tests (TAT, Rorschach, Szondi), it appears that Adolf Eichmann chiefdirector for the deportation of jewish people from 1942 to 1945 was no common individual ... [more ▼]

Under consideration of three major personality tests (TAT, Rorschach, Szondi), it appears that Adolf Eichmann chiefdirector for the deportation of jewish people from 1942 to 1945 was no common individual but a perverse sadomasochistic one with schizoparanoïd features under an osessionnal mask. These data contradict the famous opinion of Hannah Arendt about the "banality of evil". [less ▲]

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See detailA multiple-level study of metal tolerance in Salix fragilis and Salix aurita clones
Evlard, Aricia ULg; Sergeant, Kjell; Printz, Bruno et al

in Journal of Proteomics (2014), 101C

The response of two willow clones (Salix fragilis (Sf) and S. aurita (Sa)) to the presence of metals (Zn, Cu, Cd, Ni) was studied. Rooted cuttings were planted in control and contaminated soil. After 100 ... [more ▼]

The response of two willow clones (Salix fragilis (Sf) and S. aurita (Sa)) to the presence of metals (Zn, Cu, Cd, Ni) was studied. Rooted cuttings were planted in control and contaminated soil. After 100 days, different parameters (biomass, chlorophyll fluorescence (Fv/Fm), pigment and sugar concentrations, electrolyte leakage and proteome-level changes) were analyzed. The growth of Sa was not influenced by metals whereas Sf produced significantly less biomass when exposed to the pollutants. Furthermore, although Sa did not show a growth reduction in the presence of metals, the overall view of the physiological results among others the changes in the accumulation of sugars and pigments indicated that metals had a more severe impact on this clone. The response at the proteome level confirmed these observations. The growth reduction and the proteomic changes in Sf indicate that this clone adjusts its metabolism to maintain cellular homeostasis. Sa on the contrary maintains growth but the physiological and proteomics data suggests that this can only be done at the cost of cellular deregulation. Therefore high biomass is not linked with a good tolerance strategy. In a long-term study the survival of Sa might be compromised making it a poorer candidate for phytoremediation efforts. [less ▲]

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See detailAIR VERSUS GROUND TRANSPORT OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: EXPERIENCE IN A RURAL-BASED HELICOPTER MEDICAL SERVICE
MOENS, Didier ULg; Stipulante, Samuel ULg; Donneau, Anne-Françoise ULg et al

in European Journal of Emergency Medicine (2014)

Aims Primary pre-hospital Helicopter Emergency Medical Service (HEMS) interventions may play a role in timely reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI). We ... [more ▼]

Aims Primary pre-hospital Helicopter Emergency Medical Service (HEMS) interventions may play a role in timely reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI). We designed a prospective study involving patients with acute myocardial infarction aimed at the evaluation of the potential benefit of such primary HEMS interventions as compared with classical EMS ground transport. Methods & results This prospective study was conducted from July 1, 2007 to June 15, 2012. Successive patients with ST-segment elevation myocardial infarction (STEMI) eligible for percutaneous coronary intervention (PCI) were included. Simulated ground-based access times were computed using a digital cartographic program, allowing the estimation of healthcare system delay from call to admission to the catheterisation laboratory. During the study period, 4485 patients benefited from HEMS activations. Of these patients, 342 (8%) suffering from STEMI were transferred for primary PCI. Median primary response time time was 11 min (IQR: 8 - 14 min) using the helicopter and 32 min (25 – 44 min) using road transport. Median transport time using HEMS was 12 min (9 – 15 min) and 50 min (36 – 56 min) by road. The median system delay using HEMS was 52 min (45 – 60 min), while this time was 110 min (95 – 126 min) by road. Finally, the system delay median gain was 60 min (47 – 72 min). Conclusions Using HEMS in a rural region allows STEMI patients to benefit from appropriate rescue care with similar delays as those seen in urban patients. [less ▲]

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See detailThe A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits.
Parameswaran, Nevi; Dewals, Benjamin G ULg; Giles, Tom C. et al

in Virus research (2014)

Alcelaphine herpesvirus-1 (AlHV-1) causes malignant catarrhal fever (MCF). The A2 gene of AlHV-1 is a member of the bZIP transcription factor family. We wished to determine whether A2 is a virulence gene ... [more ▼]

Alcelaphine herpesvirus-1 (AlHV-1) causes malignant catarrhal fever (MCF). The A2 gene of AlHV-1 is a member of the bZIP transcription factor family. We wished to determine whether A2 is a virulence gene or not and whether it is involved in pathogenesis by interference with host transcription pathways. An A2 gene knockout (A2DeltaAlHV-1) virus, revertant (A2revAlHV-1) virus, and wild-type virus (wtAlHV-1) were used to infect three groups of rabbits. A2DeltaAlHV-1-infected rabbits succumbed to MCF, albeit with a delayed onset compared to the control groups, so A2 is not a critical virulence factor. Differential gene transcription analysis by RNAseq and qRT-PCR validation of a selection of these was performed in infected large granular lymphocyte (LGL) T cells obtained in culture from the MCF-affected animals. A2 was involved in the transcriptional regulation of immunological, cell cycle and apoptosis pathways. In particular, there was a bias towards gammadelta T cell receptor (TCR) expression and downregulation of alphabeta TCR. TCR signalling, apoptosis, cell cycle, IFN-gamma and NFAT pathways were affected. Of particular interest was partial inhibition of the cytotoxicity-associated pathways involving perforin and the granzymes A and B in the A2DeltaAlHV-1-infected LGLs compared to controls. In functional assays, A2DeltaAlHV-1-infected LGLs were significantly less cytotoxic than wtAlHV-1- and A2revAlHV-1-infected LGLs using rabbit corneal epithelial cells (SIRC) as targets. This implies that A2 is involved in a pathway enhancing the expression of LGL cytotoxicity. This is important as virus-infected T cell cytotoxicity in vivo has been suggested as a potential mechanism of disease induction in MCF. [less ▲]

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See detailThe PLATO Simulator: modelling of high-precision high-cadence space-based imaging
Marcos-Arenal, P.; Zima, W.; De Ridder, J. et al

in Astronomy and Astrophysics (2014)

Many aspects of the design trade-off of a space-based instrument and its performance can best be tackled through simulations of the expected observations. The complex interplay of various noise sources in ... [more ▼]

Many aspects of the design trade-off of a space-based instrument and its performance can best be tackled through simulations of the expected observations. The complex interplay of various noise sources in the course of the observations make such simulations an indispensable part of the assessment and design study of any space-based mission. We present a formalism to model and simulate photometric time series of CCD images by including models of the CCD and its electronics, the telescope optics, the stellar field, the jitter movements of the spacecraft, and all important natural noise sources. This formalism has been implemented in a versatile end-to-end simulation software tool, called PLATO Simulator, specifically designed for the PLATO space mission to be operated from L2, but easily adaptable to similar types of missions. We provide a detailed description of several noise sources and discuss their properties, in connection with the optical design, the allowable level of jitter, the quantum efficiency of the detectors, etc. The expected overall noise budget of generated light curves is computed as a function of the stellar magnitude, for different sets of input parameters describing the instrument properties. The simulator is offered to the scientific community for future use. [less ▲]

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See detailRates of CTL Killing in Persistent Viral Infection In Vivo
Elemans, Marjet; Florins, Arnaud; Willems, Luc ULg et al

in PLoS Computational Biology (2014), 4

The CD8+ cytotoxic T lymphocyte (CTL) response is an important defence against viral invasion. Although CTL-mediated cytotoxicity has been widely studied for many years, the rate at which virus-infected ... [more ▼]

The CD8+ cytotoxic T lymphocyte (CTL) response is an important defence against viral invasion. Although CTL-mediated cytotoxicity has been widely studied for many years, the rate at which virus-infected cells are killed in vivo by the CTL response is poorly understood. To date the rate of CTL killing in vivo has been estimated for three virus infections but the estimates differ considerably, and killing of HIV-1-infected cells was unexpectedly low. This raises questions about the typical anti-viral capability of CTL and whether CTL killing is abnormally low in HIV-1. We estimated the rate of killing of infected cells by CD8+ T cells in two distinct persistent virus infections: sheep infected with Bovine Leukemia Virus (BLV) and humans infected with Human T Lymphotropic Virus type 1 (HTLV-1) which together with existing data allows us to study a total of five viruses in parallel. Although both BLV and HTLV-1 infection are characterised by large expansions of chronically activated CTL with immediate effector function ex vivo and no evidence of overt immune suppression, our estimates are at the lower end of the reported range. This enables us to put current estimates into perspective and shows that CTL killing of HIV-infected cells may not be atypically low. The estimates at the higher end of the range are obtained in more manipulated systems and may thus represent the potential rather than the realised CTL efficiency. [less ▲]

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See detailNest grouping patterns of bonobos (Pan paniscus) in relation to fruit availability in a forest-savannah mosaic
Serckx, Adeline ULg; Huynen, Marie-Claude ULg; Bastin, Jean-François ULg et al

in PLoS ONE (2014)

A topic of major interest in socio-ecology is the comparison of chimpanzees and bonobos’ grouping patterns. Numerous studies have highlighted the impact of social and environmental factors on the ... [more ▼]

A topic of major interest in socio-ecology is the comparison of chimpanzees and bonobos’ grouping patterns. Numerous studies have highlighted the impact of social and environmental factors on the different evolution in group cohesion seen in these sister species. We are still lacking, however, key information about bonobo social traits across their habitat range, in order to make accurate inter-species comparisons. In this study we investigated bonobo social cohesiveness at nesting sites depending on fruit availability in the forest-savannah mosaic of western Democratic Republic of Congo (DRC), a bonobo habitat which has received little attention from researchers and is characterized by high food resource variation within years. We collected data on two bonobo communities. Nest counts at nesting sites were used as a proxy for night grouping patterns and were analysed with regard to fruit availability. We also modelled bonobo population density at the site in order to investigate yearly variation. We found that one community density varied across the three years of surveys, suggesting that this bonobo community has significant variability in use of its home range. This finding highlights the importance of forest connectivity, a likely prerequisite for the ability of bonobos to adapt their ranging patterns to fruit availability changes. We found no influence of overall fruit availability on bonobo cohesiveness. Only fruit availability at the nesting sites showed a positive influence, indicating that bonobos favour food ‘hot spots’ as sleeping sites. Our findings have confirmed the results obtained from previous studies carried out in the dense tropical forests of DRC. Nevertheless, in order to clarify the impact of environmental variability on bonobo social cohesiveness, we will need to make direct observations of the apes in the forest-savannah mosaic as well as make comparisons across the entirety of the bonobos’ range using systematic methodology. [less ▲]

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See detailExploiting SNP Correlations within Random Forest for Genome-Wide Association Studies
Botta, Vincent ULg; Louppe, Gilles ULg; Geurts, Pierre ULg et al

in PLoS ONE (2014)

The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however ... [more ▼]

The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however, are usually based on univariate hypothesis tests and therefore can account neither for correlations due to linkage disequilibrium nor for combinations of several markers. To discover and leverage such potential multivariate interactions, we propose in this work an extension of the Random Forest algorithm tailored for structured GWAS data. In terms of risk prediction, we show empirically on several GWAS datasets that the proposed T-Trees method significantly outperforms both the original Random Forest algorithm and standard linear models, thereby suggesting the actual existence of multivariate non-linear effects due to the combinations of several SNPs. We also demonstrate that variable importances as derived from our method can help identify relevant loci. Finally, we highlight the strong impact that quality control procedures may have, both in terms of predictive power and loci identification. [less ▲]

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See detailAtmospheric parameters and chemical properties of red giants in the CoRoT asteroseismology fields
Morel, Thierry ULg; Miglio, A.; Lagarde, N. et al

in Astronomy and Astrophysics (2014), 564

A precise characterisation of the red giants in the seismology fields of the CoRoT satellite is a prerequisite for further in-depth seismic modelling. High-resolution FEROS and HARPS spectra were obtained ... [more ▼]

A precise characterisation of the red giants in the seismology fields of the CoRoT satellite is a prerequisite for further in-depth seismic modelling. High-resolution FEROS and HARPS spectra were obtained as part of the ground-based follow-up campaigns for 19 targets holding great asteroseismic potential. These data are used to accurately estimate their fundamental parameters and the abundances of 16 chemical species in a self-consistent manner. Some powerful probes of mixing are investigated (the Li and CNO abundances, as well as the carbon isotopic ratio in a few cases). The information provided by the spectroscopic and seismic data is combined to provide more accurate physical parameters and abundances. The stars in our sample follow the general abundance trends as a function of the metallicity observed in stars of the Galactic disk. After an allowance is made for the chemical evolution of the interstellar medium, the observational signature of internal mixing phenomena is revealed through the detection at the stellar surface of the products of the CN cycle. A contamination by NeNa-cycled material in the most massive stars is also discussed. With the asteroseismic constraints, these data will pave the way for a detailed theoretical investigation of the physical processes responsible for the transport of chemical elements in evolved, low- and intermediate-mass stars. Based on observations collected at La Silla Observatory, ESO (Chile) with the FEROS and HARPS spectrograph at the 2.2 and 3.6-m telescopes under programs LP178.D-0361, LP182.D-0356, and LP185.D-0056.Appendix A is available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201322810/olm">http://www.aanda.org</A>Tables A.2 to A.6 are available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/564/A119">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/564/A119</A> [less ▲]

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See detailB fields in OB stars (BOB): The discovery of a magnetic field in a multiple system in the Trifid nebula, one of the youngest star forming regions
Hubrig, S.; Fossati, L.; Carroll, T. A. et al

in Astronomy and Astrophysics (2014), 564

<BR /> Aims: Recent magnetic field surveys in O- and B-type stars revealed that about 10% of the core-hydrogen-burning massive stars host large-scale magnetic fields. The physical origin of these fields ... [more ▼]

<BR /> Aims: Recent magnetic field surveys in O- and B-type stars revealed that about 10% of the core-hydrogen-burning massive stars host large-scale magnetic fields. The physical origin of these fields is highly debated. To identify and model the physical processes responsible for the generation of magnetic fields in massive stars, it is important to establish whether magnetic massive stars are found in very young star-forming regions or whether they are formed in close interacting binary systems. <BR /> Methods: In the framework of our ESO Large Program, we carried out low-resolution spectropolarimetric observations with FORS 2 in 2013 April of the three most massive central stars in the Trifid nebula, HD 164492A, HD 164492C, and HD 164492D. These observations indicated a strong longitudinal magnetic field of about 500-600 G in the poorly studied component HD 164492C. To confirm this detection, we used HARPS in spectropolarimetric mode on two consecutive nights in 2013 June. <BR /> Results: Our HARPS observations confirmed the longitudinal magnetic field in HD 164492C. Furthermore, the HARPS observations revealed that HD 164492C cannot be considered as a single star as it possesses one or two companions. The spectral appearance indicates that the primary is most likely of spectral type B1-B1.5 V. Since in both observing nights most spectral lines appear blended, it is currently unclear which components are magnetic. Long-term monitoring using high-resolution spectropolarimetry is necessary to separate the contribution of each component to the magnetic signal. Given the location of the system HD 164492C in one of the youngest star formation regions, this system can be considered as a Rosetta Stone for our understanding of the origin of magnetic fields in massive stars. Based on observations obtained in the framework of the ESO Prg. 191.D-0255(A,B). [less ▲]

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See detailSoil organic carbon assessment by field and airborne spectrometry in bare croplands: accounting for soil surface roughness
Denis, Antoine ULg; Stevens, Antoine; Van Wesemael, Bas et al

in Geoderma (2014), 226-227(August 2014), 94102

Visible, Near and Short Wave Infrared (VNSWIR) diffuse reflectance spectroscopy (350 nm to 2500 nm) has been proven to be an efficient tool to determine the Soil Organic Carbon (SOC) content. SOC ... [more ▼]

Visible, Near and Short Wave Infrared (VNSWIR) diffuse reflectance spectroscopy (350 nm to 2500 nm) has been proven to be an efficient tool to determine the Soil Organic Carbon (SOC) content. SOC assessment (SOCa) is usually done by using calibration samples and multivariate models. However one of the major constraints of this technique, when used in field conditions is the spatial variation in surface soil properties (soil water content, roughness, vegetation residue) which induces a spectral variability not directly related to SOC and hence reduces the SOCa accuracy. This study focuses on the impact of soil roughness on SOCa by outdoor VIS-NIR-SWIR spectroscopy and is based on the assumption that soil roughness effect can be approximated by its related shadowing effect. A new method for identifying and correcting the effect of soil shadow on reflectance spectra measured with an Analytical Spectral Devices (ASD) spectroradiometer and an Airborne Hyperspectral Sensor (AHS-160) on freshly tilled fields in the Grand Duchy of Luxembourg was elaborated and tested. This method is based on the shooting of soil vertical photographs in the visible spectrum and the derivation of a shadow correction factor resulting from the comparison of “reflectance” of shadowed and illuminated soil areas. Moreover, the study of laboratory ASD reflectance of shadowed soil samples showed that the influence of shadow on reflectance varies according to wavelength. Consequently a correction factor in the entire [350–2500 nm] spectral range was computed to translate this differential influence. Our results showed that SOCa was improved by 27% for field spectral data and by 25% for airborne spectral data by correcting the effect of soil relative shadow. However, compared to simple mathematical treatment of the spectra (first derivative, etc.) able to remove variation in soil albedo due to roughness, the proposed method, leads only to slightly more accurate SOCa. [less ▲]

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See detailSource-position transformation: an approximate invariance in strong gravitational lensing
Schneider, Peter; Sluse, Dominique ULg

in Astronomy and Astrophysics (2014), 564

The main obstacle that gravitational lensing has in determining accurate masses of deflectors, or in determining precise estimates for the Hubble constant, is the degeneracy of lensing observables with ... [more ▼]

The main obstacle that gravitational lensing has in determining accurate masses of deflectors, or in determining precise estimates for the Hubble constant, is the degeneracy of lensing observables with respect to the mass-sheet transformation (MST). The MST is a global modification of the mass distribution which leaves all image positions, shapes, and flux ratios invariant, but which changes the time delay. Here we show that another global transformation of lensing mass distributions exists which leaves image positions and flux ratios almost invariant, and of which the MST is a special case. As is the case for the MST, this new transformation only applies if one considers only those source components that are at the same distance from us. Whereas for axi-symmetric lenses this source position transformation exactly reproduces all strong lensing observables, it does so only approximately for more general lens situations. We provide crude estimates for the accuracy with which the transformed mass distribution can reproduce the same image positions as the original lens model, and present an illustrative example of its performance. This new invariance transformation is most likely the reason why the same strong lensing information can be accounted for with rather different mass models. [less ▲]

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See detailMetabolically healthy overweight and obesity
Esser, Nathalie ULg; SCHEEN, André ULg; PAQUOT, Nicolas ULg

in Annals of Internal Medicine (2014), 160(7), 514

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See detailEpoch-dependent absorption line profile variability in lambda Cep
Uuh-Sonda, J. M.; Rauw, Grégor ULg; Eenens, P. et al

in Revista Mexicana de Astronomia y Astrofisica (2014), 50

We present the analysis of a multi-epoch spectroscopic monitoring campaign of the O6 Ief star lambda Cep. Previous observations reported the existence of two modes of non-radial pulsations in this star ... [more ▼]

We present the analysis of a multi-epoch spectroscopic monitoring campaign of the O6 Ief star lambda Cep. Previous observations reported the existence of two modes of non-radial pulsations in this star. Our data reveal a much more complex situation. The frequency content of the power spectrum considerably changes from one epoch to the other. We find no stable frequency that can unambiguously be attributed to pulsations. The epoch-dependence of the frequencies and variability patterns are similar to what is seen in the wind emission lines of this and other Oef stars, suggesting that both phenomena likely have the same, currently still unknown, origin. [less ▲]

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See detailSeismic analysis of HD 43587Aa, a solar-like oscillator in a multiple system
Boumier, P.; Benomar, O.; Baudin, F. et al

in Astronomy and Astrophysics (2014), 564

Context. The object HD 43587Aa is a G0V star observed during the 145-day LRa03 run of the COnvection, ROtation and planetary Transits space mission (CoRoT), for which complementary High Accuracy Radial ... [more ▼]

Context. The object HD 43587Aa is a G0V star observed during the 145-day LRa03 run of the COnvection, ROtation and planetary Transits space mission (CoRoT), for which complementary High Accuracy Radial velocity Planet Searcher (HARPS) spectra with S/N > 300 were also obtained. Its visual magnitude is 5.71, and its effective temperature is close to 5950 K. It has a known companion in a highly eccentric orbit and is also coupled with two more distant companions. <BR /> Aims: We undertake a preliminary investigation of the internal structure of HD 43587Aa. <BR /> Methods: We carried out a seismic analysis of the star, using maximum likelihood estimators and Markov chain Monte Carlo methods. <BR /> Results: We established the first table of the eigenmode frequencies, widths, and heights for HD 43587Aa. The star appears to have a mass and a radius slightly larger than the Sun, and is slightly older (5.6 Gyr). Two scenarios are suggested for the geometry of the star: either its inclination angle is very low, or the rotation velocity of the star is very low. <BR /> Conclusions: A more detailed study of the rotation and of the magnetic and chromospheric activity for this star is needed, and will be the subject of a further study. New high resolution spectrometric observations should be performed for at least several months in duration. [less ▲]

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See detailConceptual metaphors as a tool for the efficient teaching of Dutch and German posture verbs
De Knop, Sabine; Perrez, Julien ULg

in Review of Cognitive Linguistics (2014), 12(1), 1-29

The article deals with the typological differences between the Romance lan- guage French and the Germanic languages German and Dutch for the linguistic expressions of posture and location. It describes ... [more ▼]

The article deals with the typological differences between the Romance lan- guage French and the Germanic languages German and Dutch for the linguistic expressions of posture and location. It describes how these typological differ- ences can be problematic for French-speaking learners of German and Dutch. The main difference between both types of languages is that posture and loca- tion tend to be encoded by posture verbs in Germanic languages and by very general verbs in Romance languages (Talmy 2000). After a detailed description of the semantic networks of the German and Dutch posture verbs, the paper takes a critical look at how these expressions are dealt with in teaching manuals. It further presents strategies for the efficient teaching of posture verbs to foreign language learners. These strategies are among others awareness-raising exercis- es about the compulsory use of posture verbs in Germanic languages and the description of conceptual metaphors in different languages. These pedagogical avenues for the efficient teaching of the Dutch and German posture verbs con- stitute a first step towards the elaboration of an experimental set-up aiming at verifying them. [less ▲]

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See detailThe BANANA Project. V. Misaligned and Precessing Stellar Rotation Axes in CV Velorum
Albrecht, Simon; Winn, Joshua N.; Torres, Guillermo et al

in Astrophysical Journal (2014), 785

As part of the Binaries Are Not Always Neatly Aligned project (BANANA), we have found that the eclipsing binary CV Velorum has misaligned rotation axes. Based on our analysis of the Rossiter-McLaughlin ... [more ▼]

As part of the Binaries Are Not Always Neatly Aligned project (BANANA), we have found that the eclipsing binary CV Velorum has misaligned rotation axes. Based on our analysis of the Rossiter-McLaughlin effect, we find sky-projected spin-orbit angles of β[SUB]p[/SUB] = -52° ± 6° and β[SUB]s[/SUB] = 3° ± 7° for the primary and secondary stars (B2.5V + B2.5V, P = 6.9 days). We combine this information with several measurements of changing projected stellar rotation speeds (vsin i [SUB]sstarf[/SUB]) over the last 30 yr, leading to a model in which the primary star's obliquity is ≈65°, and its spin axis precesses around the total angular momentum vector with a period of about 140 yr. The geometry of the secondary star is less clear, although a significant obliquity is also implicated by the observed time variations in the vsin i [SUB]sstarf[/SUB]. By integrating the secular tidal evolution equations backward in time, we find that the system could have evolved from a state of even stronger misalignment similar to DI Herculis, a younger but otherwise comparable binary. Based on observations made with ESOs 2.2 m Telescopes at the La Silla Paranal Observatory under programme ID 084.C-1008 and under MPIA guaranteed time. [less ▲]

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See detailLong term Immune Reconstitution and infection burden after Mismatched Hematopoietic Stem Cell Transplantation
SERVAIS, Sophie ULg; Lengline, Etienne; Porcher, Raphael et al

in Biology of Blood & Marrow Transplantation (2014), 20(4), 507-517

Mismatched unrelated donor (MMUD) or umbilical cord blood (UCB) can be chosen as alternative donors for allogeneic stem cell transplantation but might be associated with long lasting immune deficiency ... [more ▼]

Mismatched unrelated donor (MMUD) or umbilical cord blood (UCB) can be chosen as alternative donors for allogeneic stem cell transplantation but might be associated with long lasting immune deficiency. Sixty-six patients who underwent a first transplantation from either UCB or 9/10 MMUD (n= 36) and who survived beyond 3 months were evaluated. Immune reconstitution was prospectively assessed at sequential time points after transplantation. NK, B, CD4+ and CD8+T cells and their subsets as well as regulatory T cells (Treg) were studied. Detailed analyses on infections occurring after 3 months were also assessed. The 18-month cumulative incidences of infection-related death were 8 and 3%, and of infections were 72 and 57% after MMUD and UCB transplantation, respectively. Rates of infection per 12 patient-month were roughly 2 overall (1 for bacterial, 0.9 for viral and 0.3 for fungal infections). Memory, naïve CD4+ and CD8+T cells, naïve B cells and Treg cells reconstitution between the 2 sources was roughly similar. Absolute CD4+T cells hardly reached 500 per μL by one year posttransplantation and most B cells were of naïve phenotype. Correlations between immune reconstitution and infection were then performed by multivariate analyses. Low CD4+ and high CD8+T cells absolute counts at 3 months were linked to increased risks of overall and viral (but not bacterial) infections. When assessing for the naïve/memory phenotypes at 3 months among the CD4+ T cell compartment, higher percentages of memory subsets were protective against late infections: central memory CD4+T cells protected against overall and bacterial infections; late effector memory CD4+T cells protected against overall, bacterial and viral infections. At the opposite, high percentage of effector- and late effector-memory subsets at 3 months among the CD8+ T cell compartment predicted higher risks for viral infections. Patients transplanted from alternative donors represent a population with very high risk of infection. Detailed phenotypic analysis of immune reconstitution may help to evaluate infection risk and to adjust infection prophylaxis. [less ▲]

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See detailValidation analytique d'une méthode chromatographique destinée à rechercher et à identifier les opiacés naturels ou (semi) synthétiques
DUBOIS, Nathalie ULg; Counerotte, Stéphane ULg; Goffin, Eric ULg et al

in Annales de Biologie Clinique (2014), 72(2), 197-206

L’identification de la substance absorbée par un consommateur d’opiacés peut être problématique dans la mesure où il n’existe pas de biomarqueur spécifique pour toutes les molécules. Nous avons développé ... [more ▼]

L’identification de la substance absorbée par un consommateur d’opiacés peut être problématique dans la mesure où il n’existe pas de biomarqueur spécifique pour toutes les molécules. Nous avons développé une technique de chromatographie liquide ultra-haute pression couplée à un spectromètre de masse en tandem qui permet l’identification et le dosage de 25 opiacés dans le plasma. La préparation de l’échantillon consiste en une extraction en phase solide sur colonnes Oasis ® MCX (Waters). La méthode a été validée selon les critères préconisés par la FDA, complètement pour 21 substances et avec quelques réserves pour les 4 produits restants. Cette méthode a été appliquée à 80 patients traités au CHU de Liège pour lesquels la recherche d’opiacés était positive. L’identification du produit consommé a été effective dans 86 % des cas. [less ▲]

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See detailBone sialoprotein as a potential key factor implicated in the pathophysiology of osteoarthritis
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Walsh, David et al

in Osteoarthritis and Cartilage (2014), 22(4), 547-56

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See detailLe nouveau fichier écologique des essences. Pourquoi et comment ?
Claessens, Hugues ULg; Bifolchi, Eva; Cordier, Sophie ULg et al

in Forêt Wallonne (2014), (129), 60-70

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See detailWidespread occurence of expressed fungal secretory peroxydases in forest soils
Kellner, Harald; Luis, Patricia; Pecyna, Marek, J. et al

in PLoS ONE (2014), 9(4),

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See detailExigences administratives et condition suspensive dans la vente immobilière
Kohl, Benoît ULg; Onclin, François ULg

in Revue Critique de Jurisprudence Belge [= RCJB] (2014), (1), 13-55

Cette étude est consacrée à l'utilisation de la condition suspensive en lien avec les exigences administratives, dans la matière spécifique de la vente immobilière. Le foisonnement des exigences de nature ... [more ▼]

Cette étude est consacrée à l'utilisation de la condition suspensive en lien avec les exigences administratives, dans la matière spécifique de la vente immobilière. Le foisonnement des exigences de nature urbanistique, environnementale et énergétique, en lien avec les biens immeubles, pousse les intervenants à la vente de biens immeubles - qu'il s'agisse de particuliers ou de professionnels - à recourir à la modalité de la condition suspensive. Se pose dès lors la question de la validité de cette pratique. Cette contribution suit en réalité un arrêt de la Cour de cassation du 24 février 2011 qui porte sur la conclusion de la vente d'une parcelle, issue de la division d'un bien, sous la condition suspensive de la délivrance d'un permis de lotir. L'étude se divise en deux parties. La première offre un rappel, bien nécessaire, du droit commun. Elle analyse donc les différentes composantes de la condition suspensive. La seconde étudie, de manière plus spécifique, la mise sous condition suspensive de différentes exigences administratives en lien avec la vente immobilière. L'arrêt de la Cour de cassation précité y est notamment commenté. [less ▲]

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See detailNetamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their Antimalarial Activity.
Gros, Emmanuelle; Al-Mourabit, Ali; Martin, Marie-Therese et al

in Journal of natural products (2014), 77(4), 818-23

Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known ... [more ▼]

Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 muM. [less ▲]

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See detailThe rewriting ethos of the Vertigo imprint: critical perspectives on memory-making and canon formation in the American comics field
Dony, Christophe ULg

in Comicalités : Études de Culture Graphique (2014)

This essay investigates how and why strategies of rewriting have been central to Vertigo’s poetics and editorial project for over twenty years. Drawing notably on the works of Harold Bloom, Thierry ... [more ▼]

This essay investigates how and why strategies of rewriting have been central to Vertigo’s poetics and editorial project for over twenty years. Drawing notably on the works of Harold Bloom, Thierry Groensteen, and Geoffrey Klock, it first proceeds to establish the relevance of the concept of rewriting as it can be applied to comics (studies), particularly in showing how inter- and hypertextual relations are inherently connected to issues of nostalgia, memory as well as lineage, and therefore to processes of (self-)canonization and discourses of cultural legitimacy. It then moves on to identify some of the label's rewriting trends and discusses how they engage both intro- and retrospectively with the comics form, its history, and its (renewed) perception in the American context. More specifically, in recurrently paying homage to the DC archive, the pulp heritage, as well as to the Gothic tradition, it is my contention that Vertigo has participated in a critical logic of commemoration that distances itself from the mnemonic discourses championed by both the mainstream and alternative poles of the comics industry. In so doing, Vertigo may have attempted to create a canon of its own while certainly challenging Groensteen's claim that comics is an “art without memory”. But perhaps more importantly, the essay concludes that Vertigo's cherishing of specific rewriting strategies has helped it adopt a politics of demarcation in regards to the structuring forces of the American comics field, a politics that not only subverts the field's power relations dynamics but also “writes back” to its practices of domination and exclusion. [less ▲]

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See detailLong term Immune Reconstitution and infection burden after Mismatched Hematopoietic Stem Cell Transplantation
SERVAIS, Sophie ULg; Lengline, Etienne; Porcher, Raphael et al

in Biology of Blood & Marrow Transplantation (2014), 20(4), 507-517

Mismatched unrelated donor (MMUD) or umbilical cord blood (UCB) can be chosen as alternative donors for allogeneic stem cell transplantation but might be associated with long lasting immune deficiency ... [more ▼]

Mismatched unrelated donor (MMUD) or umbilical cord blood (UCB) can be chosen as alternative donors for allogeneic stem cell transplantation but might be associated with long lasting immune deficiency. Sixty-six patients who underwent a first transplantation from either UCB or 9/10 MMUD (n= 36) and who survived beyond 3 months were evaluated. Immune reconstitution was prospectively assessed at sequential time points after transplantation. NK, B, CD4+ and CD8+T cells and their subsets as well as regulatory T cells (Treg) were studied. Detailed analyses on infections occurring after 3 months were also assessed. The 18-month cumulative incidences of infection-related death were 8 and 3%, and of infections were 72 and 57% after MMUD and UCB transplantation, respectively. Rates of infection per 12 patient-month were roughly 2 overall (1 for bacterial, 0.9 for viral and 0.3 for fungal infections). Memory, naïve CD4+ and CD8+T cells, naïve B cells and Treg cells reconstitution between the 2 sources was roughly similar. Absolute CD4+T cells hardly reached 500 per μL by one year posttransplantation and most B cells were of naïve phenotype. Correlations between immune reconstitution and infection were then performed by multivariate analyses. Low CD4+ and high CD8+T cells absolute counts at 3 months were linked to increased risks of overall and viral (but not bacterial) infections. When assessing for the naïve/memory phenotypes at 3 months among the CD4+ T cell compartment, higher percentages of memory subsets were protective against late infections: central memory CD4+T cells protected against overall and bacterial infections; late effector memory CD4+T cells protected against overall, bacterial and viral infections. At the opposite, high percentage of effector- and late effector-memory subsets at 3 months among the CD8+ T cell compartment predicted higher risks for viral infections. Patients transplanted from alternative donors represent a population with very high risk of infection. Detailed phenotypic analysis of immune reconstitution may help to evaluate infection risk and to adjust infection prophylaxis. [less ▲]

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See detailAircraft Engine Gas Path Diagnostic Methods: Public Benchmarking Results
Simon, Donald; Borguet, Sébastien ULg; Léonard, Olivier ULg et al

in Journal of Engineering for Gas Turbines & Power (2014), 136(4), 041201

Recent technology reviews have identified the need for objective assessments of aircraft engine health management (EHM) technologies. To help address this issue, a gas path diagnostic benchmark problem ... [more ▼]

Recent technology reviews have identified the need for objective assessments of aircraft engine health management (EHM) technologies. To help address this issue, a gas path diagnostic benchmark problem has been created and made publicly available. This software tool, referred to as the Propulsion Diagnostic Method Evaluation Strategy (Pro- DiMES), has been constructed based on feedback provided by the aircraft EHM community. It provides a standard benchmark problem enabling users to develop, evaluate, and compare diagnostic methods. This paper will present an overview of ProDiMES along with a description of four gas path diagnostic methods developed and applied to the problem. These methods, which include analytical and empirical diagnostic techniques, will be described and associated blind-test-case metric results will be presented and compared. Lessons learned along with recommendations for improving the public benchmarking processes will also be presented and discussed. [less ▲]

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See detailBiased binomial assessment of cross-validated estimation of classification accuracies illustrated in diagnosis predictions
Noirhomme, Quentin ULg; Lesenfants, Damien ULg; Gomez, Francisco et al

in NeuroImage: Clinical (2014), 4

Multivariate classification is used in neuroimaging studies to infer brain activation or in medical applications to infer diagnosis. Their results are often assessed through either a binomial or a ... [more ▼]

Multivariate classification is used in neuroimaging studies to infer brain activation or in medical applications to infer diagnosis. Their results are often assessed through either a binomial or a permutation test. Here, we simulated classification results of generated random data to assess the influence of the cross-validation scheme on the significance of results. Distributions built from classification of random data with crossvalidation did not follow the binomial distribution. The binomial test is therefore not adapted. On the contrary, the permutation test was unaffected by the cross-validation scheme. The influence of the crossvalidation was further illustrated on real-data from a brain–computer interface experiment in patients with disorders of consciousness and from an fMRI study on patients with Parkinson disease. Three out of 16 patients with disorders of consciousness had significant accuracy on binomial testing, but only one showed significant accuracy using permutation testing. In the fMRI experiment, the mental imagery of gait could discriminate significantly between idiopathic Parkinson’s disease patients and healthy subjects according to the permutation test but not according to the binomial test. Hence, binomial testing could lead to biased estimation of significance and false positive or negative results. In our view, permutation testing is thus recommended for clinical application of classification with cross-validation. [less ▲]

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See detailLa relation structure chimique-propriétés physiques des galactomannanes extraits de la caroube
Gillet, Sébastien ULg; Blecker, Christophe ULg; Paquot, Michel ULg et al

in Comptes Rendus Chimie (2014), 17(4),

Carob galactomannan fine chemical structure is closely related to the physical behavior developed in aqueous solution. Three elements of structural characterization are mainly described in the literature ... [more ▼]

Carob galactomannan fine chemical structure is closely related to the physical behavior developed in aqueous solution. Three elements of structural characterization are mainly described in the literature: the degree of galactose substitution, chain length, and galactose units distribution. This review article will attempt to highlight the impact of different structural features on physical properties such as solubility, viscosity, formation of hydrogels or gels in combination with other saccharides. The impact of industrial purification process on the structure and physical properties is also developed. [less ▲]

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See detailPrise en charge de l'angiocholite
GAST, Pierrette ULg

in Revue Médicale de Liège (2014), 69(4), 226-228

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See detailInfluence of noise correction on intra- and inter-subject variability of quantitative metrics in diffusion kurtosis imaging
André, Elodie ULg; Grinberg, Farida; Farrher, Ezequiel et al

in PLoS ONE (2014)

Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing new biomarkers. Given the rapidly increasing ... [more ▼]

Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing new biomarkers. Given the rapidly increasing number of studies, DKI has a potential to establish itself as a valuable tool in brain diagnostics. However, to become a routine procedure, DKI still needs to be improved in terms of robustness, reliability, and reproducibility. As it requires acquisitions at higher diffusion31 weightings, results are more affected by noise than in diffusion tensor imaging. The lack of standard procedures for post-processing, especially for noise correction, might become a significant obstacle for the use of DKI in clinical routine limiting its application. We considered two noise correction schemes accounting for the noise properties of multichannel phased-array coils, in order to improve the data quality at signal-to-noise ratio (SNR) typical for DKI. The SNR dependence of estimated DKI metrics such as mean kurtosis (MK), mean diffusivity (MD) and fractional anisotropy (FA) is investigated for these noise correction approaches in Monte Carlo simulations and in in vivo human studies. The intra-subject reproducibility is investigated in a single subject study by varying the SNR level and SNR spatial distribution. Then the impact of the noise correction on inter-subject variability is evaluated in a homogeneous sample of 25 healthy volunteers. Results show a strong impact of noise correction on the MK estimate, while the estimation of FA and MD was affected to a lesser extent. Both intra- and inter-subject SNR related variability of the MK estimate is considerably reduced after correction for the noise bias, providing more accurate and reproducible measures. In this work, we have proposed a straightforward method that improves accuracy of DKI metrics. This should contribute to standardization of DKI applications in clinical studies and making valuable inferences in group analysis and longitudinal studies. [less ▲]

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See detailEnjeux autour des forêts congolaises
Vermeulen, Cédric ULg

in Cahiers africains (2014), 84

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See detailProjet TADAM: Conclusions scientifiques et recommandations
Lemaître, André ULg; ANSSEAU, Marc ULg; Demaret, Isabelle ULg

in Lettre du RESPADD (2014), (18), 2-4

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See detailImportance of synovitis in osteoarthritis: Evidence for the use of glycosaminoglycans against synovial inflammation.
Henrotin, Yves ULg; Lambert, Cécile ULg; Richette, Pascal

in Seminars in Arthritis & Rheumatism (2014), 43(5), 579-87

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See detailLa régénération naturelle des hêtraies-chênaies en lumière : approche expérimentale en forêt ardennaise
Ligot, Gauthier ULg; Claessens, Hugues ULg; Baudry, Olivier et al

in Forêt Wallonne (2014), (129), 19-21

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See detailCrystal Chemistry of Synthetic M(2+)Be2P2O8 (M(2+) = Ca, Sr, Pb, Ba) Beryllophosphates
Dal Bo, Fabrice ULg; Hatert, Frédéric ULg; Baijot, Maxime ULg

in Canadian Mineralogist (2014), 52(2), 337-350

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See detailSensitivity analysis of oscillator models in the space of phase response curves: Oscillators as open systems
Sacré, Pierre ULg; Sepulchre, Rodolphe ULg

in IEEE Control Systems Magazine (2014), 34(2), 50-74

Detailed reference viewed: 11 (0 ULg)