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See detailVisual hallucinations in the psychosis-spectrum, and comparative information from neurodegenerative disorders and eye disease
Waters, F; Collerton, D; ffytche, D et al

in Schizophrenia Bulletin (2014), 40

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See detailCarriage and acquisition rates of Clostridium difficile in hospitalized horses, including molecular characterization, multilocus sequence typing and antimicrobial susceptibility of bacterial isolates
Rodriguez Diaz, Cristina ULg; Taminiau, Bernard ULg; Brévers, Bastien et al

in Veterinary Microbiology (2014)

lostridium difficile has been identified as a significant agent of diarrhoea and enterocolitis in both foals and adult horses. Hospitalization, antibiotic therapy or changes in diet may contribute to the ... [more ▼]

lostridium difficile has been identified as a significant agent of diarrhoea and enterocolitis in both foals and adult horses. Hospitalization, antibiotic therapy or changes in diet may contribute to the development of C. difficile infection. Horses admitted to a care unit are therefore at greater risk of being colonized. The aim of this study was to investigate the carriage of C. difficile in hospitalized horses and the possible influence of some risk factors in colonization. During a seven-month period, faecal samples and data relating the clinical history of horses admitted to a veterinary teaching hospital were collected. C. difficile isolates were characterized through toxin profiles, cytotoxicity activity, PCR-ribotyping, antimicrobial resistance and multilocus sequence typing (MLST). Ten isolates were obtained with a total of seven different PCR-ribotypes, including PCR-ribotype 014. Five of them were identified as toxinogenic. A high resistance to gentamicin, clindamycin and ceftiofur was found. MLST revealed four different sequencing types (ST), which included ST11, ST26, ST2 and ST15, and phylogenetic analysis showed that most of the isolates clustered in the same lineage. Clinical history suggests that horses frequently harbour toxigenic and non-toxigenic C. difficile and that in most cases they are colonized regardless of the reason for hospitalization; the development of diarrhoea is more unusual. [less ▲]

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See detailEnhancing a CH-pi interaction to increase the affinity for 5-HT1A receptors
Liégeois, Jean-François ULg; Lespagnard, Marc; Meneses Salas, Elsa et al

in ACS Medicinal Chemistry Letters (2014), 5

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6 ... [more ▼]

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6-tetrahydropyridine (THP) analogue compared to the corresponding 4-phenylpiperazine analogue. To explore a possible reinforcement of this interaction to increase the affinity for 5-HT1A receptors, different 4-substituted-phenyl analogues were synthesized and tested. The most important increase of affinity is obtained with two electron-donating methyl groups in position 3 and 5 [less ▲]

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See detailThe impact of aging and hearing status on verbal working memory
Verhaegen, Clémence ULg; Collette, Fabienne ULg; Majerus, Steve ULg

in Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition (2014), 21(4), 464-482

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See detailEffects of melody and technique on acoustical and musical features of Western operatic singing voices
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Journal of Voice (2014)

Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains ... [more ▼]

Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains unclear. This study aims to further characterize the Western operatic singing technique by observing the effects of melody and technique on acoustical and musical parameters of the singing voice. Methods: Fifty professional singers performed two contrasting melodies (popular song and romantic melody) with two vocal techniques (with and without operatic singing technique). The common quality parameters (energy distribution, vibrato rate and extent), perturbation parameters (standard deviation of the fundamental frequency, signal-to-noise ratio, jitter and shimmer) and musical features (fundamental frequency of the starting note, average tempo, and sound pressure level) of the 200 sung performances were analyzed. Results: The results regarding the effect of melody and technique on the acoustical and musical parameters show that the choice of melody had a limited impact on the parameters observed, whereas a particular vocal profile appeared depending on the vocal technique employed. Conclusions: This study confirms that vocal technique affects most of the parameters examined. In addition, the observation of quality, perturbation and musical parameters contributes to a better understanding of the Western operatic singing technique. [less ▲]

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See detailDensity estimates and nesting-site selection in chimpanzees of the Nimba Mountains, Côte d'Ivoire and Guinea
Granier, Nicolas ULg; Hambuckers, Alain ULg; Matsuzawa et al

in American Journal of Primatology (2014)

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked ... [more ▼]

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked 80 km of transects and recces each month, and recorded 764 nests (mean group size = 2.23 nests) along with characteristics of vegetation structure and composition, topography and seasonality. Population density estimated with two nest count methods ranged between 0.14 and 0.65 chimpanzee/km2. These values are lower than previous estimates, emphasizing the necessity of protecting remaining wild ape populations. Chimpanzees built nests in 108 tree species out of 437 identified, but 2.3% of total species comprised 52% of nests. Despite they preferred nesting in trees of 25-29 cm DBH and at a mean height of 8.02 m, we recorded an important proportion of terrestrial nests (8.2%) that may reflect a cultural trait of Nimba chimpanzees. A logistic model of nest presence formulated as a function of 12 habitat variables revealed preference for gallery and mountain forests rather than lowland forest, and old-growth forest rather than secondary forests. They nested more frequently in the study area during the dry season (December-April). The highest probability of observing nests was at 770 m altitude, particularly in steep locations (mean ground declivity = 15.54%). Several of the reported nest characteristics combined with the existence of 2 geographically separated clusters of nest, suggest that the study area constitutes the non-overlapping peripheral areas of 2 distinct communities. This nest-based study led us to findings on the behavioral ecology of Nimba chimpanzees, which constitute crucial knowledge to implement efficient and purpose-built conservation. [less ▲]

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See detailEcosystem services of mixed species forest stands and monocultures: comparing practitioners' and scientists' perceptions with formal scientific knowledge
Carnol, Monique ULg; Baeten, Lander; Branquart, Etienne et al

in Forestry (2014)

Mixed species stands might contribute to important goals of sustainable forest management, such as higher biological diversity, more resistance and resilience to disturbances and higher carbon storage ... [more ▼]

Mixed species stands might contribute to important goals of sustainable forest management, such as higher biological diversity, more resistance and resilience to disturbances and higher carbon storage. Knowledge of stakeholders' perceptions of such ecosystem services in mixed species stands is required for effective policy development. We showed that practitioners' and scientists' perceptions of ecosystem services in mixed species stands in Belgium differed from formal scientific knowledge derived from a synthesis of published studies. The positive perception of supporting, regulating and cultural services in mixed species stands contrasted with less conclusive results from the literature, where positive, negative and neutral effects were reported. Many respondents also signified a lack of information about regulating services. Furthermore, provisioning services were perceived as equal in mixed species stands and monocultures, in contrast to higher productivity demonstrated in mixed species stands in the literature. The regional (Flanders and Wallonia) ecological and socio-economic context influenced both the perception of ecosystem services and of the importance of management objectives. Our results highlighted the need to address the lack of scientific data, to adapt communication to the ecological and socio-economic context, as well as to improve information flow on regulating services and productivity. [less ▲]

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See detailLa réflexivité : de la vertu épistémologique aux versions mises en rapports, en passant par les incidents diplomatiques
Thoreau, François ULg; Despret, Vinciane ULg

in Revue d'Anthropologie des Connaissances (2014), 8(2), 391-424

Dans cet article, nous proposons la mise en œuvre d’un dispositif d’enquête que nous qualifions de « diplomatique ». L’objet de cette enquête est la question de la réflexivité des scientifiques. Tout ... [more ▼]

Dans cet article, nous proposons la mise en œuvre d’un dispositif d’enquête que nous qualifions de « diplomatique ». L’objet de cette enquête est la question de la réflexivité des scientifiques. Tout au long de l’article, nous explorons avec les scientifiques que nous avons rencontrés différents modes sur lesquels peut se décliner cette « réflexivité ». Toutefois, chacun de ces modes nous invite à considérer plusieurs manières de partager ce problème et de le construire avec eux. Chemin faisant, il n’y a donc pas que la question de la réflexivité qui bifurque, mais également le sens même de l’approche diplomatique pour laquelle nous avons opté. C’est à cette exploration conjointe des significations de la réflexivité des scientifiques et des modalités de la diplomatie que nous convions le lecteur. [less ▲]

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See detailEffect of gamma-hydroxybutyrate on keratinocytes proliferation: a preliminary prospective controlled study in severe burn patients.
ROUSSEAU, Anne-Françoise ULg; BARGUES, Laurent; LE BEVER, Hervé et al

in International Journal of Critical Illness and Injury Science (2014), 4(2), 108-113

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See detailLa recette commentée sur la toile: un genre renouvelé?
Meunier, Deborah ULg; Rosier, Laurence

in Arena Romanistica (2014), 14

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of ... [more ▼]

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of the recipe’s very form, which was initially a case of linear transmission in a chronological sense, towards a dialogal and polyphonic form in which the original posted recipe becomes recipe only when it is enlivened with commentaries which complete and perform it. Our contribution aims to show this discursive co-construction. From the point of view of genres, we will also see that those genres which are known as monologal or fixed can evolve towards dialogal and dialogical forms. [less ▲]

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See detailNanoparticle Growth in Supported Nickel Catalysts during Methanation Reaction-Larger is Better
Munnik, Peter; Velthoen, Marjolein; de Jongh, Petra et al

in Angewandte Chemie International Edition (2014)

A major cause of supported metal catalyst deactivation is particle growth by Ostwald ripening. Nickel catalysts, used in the methanation reaction, may suffer greatly from this through the formation of [Ni ... [more ▼]

A major cause of supported metal catalyst deactivation is particle growth by Ostwald ripening. Nickel catalysts, used in the methanation reaction, may suffer greatly from this through the formation of [Ni(CO)4]. By analyzing catalysts with various particle sizes and spatial distributions, the interparticle distance was found to have little effect on the stability, because formation and decomposition of nickel carbonyl rather than diffusion was rate limiting. Small particles (3–4 nm) were found to grow very large (20–200 nm), involving local destruction of the support, which was detrimental to the catalyst stability. However, medium sized particles (8 nm) remained confined by the pores of the support displaying enhanced stability, and an activity 3 times higher than initially small particles after 150 h. Physical modeling suggests that the higher [Ni(CO)4] supersaturation in catalysts with smaller particles enabled them to overcome the mechanical resistance of the support. Understanding the interplay of particle size and support properties related to the stability of nanoparticles offers the prospect of novel strategies to develop more stable nanostructured materials, also for applications beyond catalysis. [less ▲]

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See detailControllable morphology of flux avalanches in microstructured superconductors
Motta, M.; Colauto, F.; Vestgarden, J.I. et al

in Physical Review. B : Condensed Matter (2014)

The morphology of abrupt bursts of magnetic flux into superconducting films with engineered periodic pinning centers (antidots) has been investigated. Guided flux avalanches of thermomagnetic origin ... [more ▼]

The morphology of abrupt bursts of magnetic flux into superconducting films with engineered periodic pinning centers (antidots) has been investigated. Guided flux avalanches of thermomagnetic origin develop a tree-like structure, with the main trunk perpendicular to the borders of the sample, while secondary branches follow well-defi ned directions determined by the geometrical details of the underlying periodic pinning landscape. Strikingly, we demonstrate that in a superconductor with relatively weak random pinning, the morphology of such flux avalanches can be fully controlled by proper combinations of lattice symmetry and antidot geometry. Moreover, the resulting flux patterns can be reproduced, to the fi nest details, by simulations based on a phenomenological thermomagnetic model. In turn, this model can be used to predict such complex structures and to estimate physical variables of more di fficult experimental access, such as the local values of temperature and electric fi eld. [less ▲]

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See detailLa vignette diagnostique de l'étudiant. Diagnostic et évolution d'une chéloïde.
FRANCHIMONT, Claudine ULg; Hermanns-Lê, Trinh ULg; NIZET, Jean-Luc ULg et al

in Revue Médicale de Liège (2014), 69

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière ... [more ▼]

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière d’une cicatrice et, d’autre part, à une apparition présumée spontanée. Cette lésion est caractérisée par des dépôts massifs de faisceaux de collagène. Cet aspect la distingue de la cicatrice hypertrophique qui représente, de manière primordiale, une accumulation de fibroblastes et de petits vaisseaux. [less ▲]

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See detailSeismically-triggered organic-rich layers in recent sediments from lake Gollukoy (North Anatolian Fault, Turkey
Avşar, Ulaş; Hubert, Aurelia ULg; De Batist, Marc et al

in Quaternary Science Reviews (2014), 103

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See detailEffects of glucose-lowering agents on vascular outcomes in type 2 diabetes: A critical reappraisal.
Scheen, André ULg; Charbonnel, B.

in Diabetes & metabolism (2014)

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major ... [more ▼]

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain how hyperglycaemia induces vascular damage. However, randomized controlled trials investigating either an intensive glucose-lowering strategy vs standard care or the addition of a new glucose-lowering agent vs a placebo have largely failed to demonstrate any clinical benefits in terms of cardiovascular morbidity or mortality. This lack of evidence has led some people to contest the clinical efficacy of lowering blood glucose in patients with T2DM, despite its positive effects on microvascular complications. This article analyzes the various reasons that might explain such discrepancies. There are still strong arguments in favour of targeting hyperglycaemia while avoiding other counterproductive effects, such as hypoglycaemia and weight gain, and of integrating the glucose-lowering approach within a global multi-risk strategy to reduce the burden of cardiovascular disease in T2DM. [less ▲]

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See detailCriteria and tools for objectively analysing the vocal accuracy of a popular song
Larrouy, Pauline ULg; Morsomme, Dominique ULg

in Logopedics, Phoniatrics, Vocology (2014), 39

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt ... [more ▼]

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt and OpenMusic (Ircam, Paris, France). In terms of evaluation of the pitch interval deviation, we replicated the profile of occasional singers described in the literature (the slower the performance, the more accurate it is). Our results also confirm that the professional singers sing more accurately than occasional singers but not when a Western operatic singing technique is involved. These results support the relevance of our method for analysing vocal accuracy of occasional and professional singers and led us to discuss adaptations to be implemented for analysing the accuracy of operatic voices. [less ▲]

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See detailProtection against muscle damage induced by electrical stimulation: efficiency of a preconditioning programme
Vanderthommen, Marc ULg; Chamayou, Remy; Demoulin, Christophe ULg et al

in Clinical Physiology & Functional Imaging (2014)

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See detailA Givetian tintinnid-like palynomorph from Libya.
Steemans, Philippe ULg; Breuer, P.; Ville de Goyet, F. de et al

in Review of Palaeobotany and Palynology (2014), ?

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See detailPEGylation of antibody fragments greatly increases their local residence time following delivery to the respiratory tract.
Koussoroplis, Salome Juliette; Paulissen, Geneviève ULg; Tyteca, Donatienne et al

in Journal of Controlled Release (2014), sous presse

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The ... [more ▼]

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The aim of this research was to study the effects of the PEGylation of antibody fragments on their local residence time after administration to the respiratory tract. We demonstrate that the conjugation of a two-armed 40-kDa polyethylene glycol (PEG) chain to anti-interleukin-17A (IL-17A) F(ab')2 and anti-IL-13 Fab' greatly prolonged the presence of these fragments within the lungs of mice. The content of PEGylated antibody fragments within the lungs plateaued up to 4hours post-delivery, whereas clearance of unconjugated proteins started immediately after administration. Forty-eight hours post-delivery, F(ab')2 and Fab' content in the lungs had decreased to 10 and 14 % of the dose initially deposited, respectively. However, this value was 40 % for both PEG40-F(ab')2 and PEG40-Fab'. The prolonged pulmonary residency of the anti-IL-17A PEG40-F(ab')2 translated into an improved efficacy in reducing lung inflammation in a murine model of house dust mite-induced lung inflammation. We demonstrate that PEGylated proteins were principally retained within the lung lumen rather than the nasal cavities or lung parenchyma. In addition, we report that PEG increased pulmonary retention of antibody fragments through mucoadhesion and escape from alveolar macrophages rather than increased hydrodynamic size or improved enzymatic stability. The PEGylation of proteins might find broad application in the local delivery of therapeutic proteins to diseased airways. [less ▲]

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See detailFirst-principles study of vibrational and noncollinear magnetic properties of the perovskite to postperovskite pressure transition of $NaMnF_3$
Garcia-Castro, A. C.; Romero, A. H.; Bousquet, Eric ULg

in Physical Review. B, Condensed Matter and Materials Physics (2014), 90

We performed a first-principles study of the structural, vibrational, electronic, and magnetic properties of NaMnF3 under applied isotropic pressure. We found that NaMnF3 undergoes a reconstructive phase ... [more ▼]

We performed a first-principles study of the structural, vibrational, electronic, and magnetic properties of NaMnF3 under applied isotropic pressure. We found that NaMnF3 undergoes a reconstructive phase transition at 8 GPa from the Pnma distorted perovskite structure toward the Cmcm postperovskite structure. This is confirmed by a sudden change of the Mn-F-Mn bondings where the crystal goes from corner-shared octahedra in the Pnma phase to edge-shared octahedra in the Cmcm phase. The magnetic ordering also changes from a G-type antiferromagnetic ordering in the Pnma phase to a C-type antiferromagnetic ordering in the Cmcm phase. Interestingly, we found that the high-spin d-orbital filling is kept at the phase transition which has never been observed in the known magnetic postperovskite structures. We also found a highly noncollinear magnetic ordering in the Cmcm postperovskite phase that drives a large ferromagnetic canting of the spins. We discuss the validity of these results with respect to the U and J parameters of the GGA+U exchange-correlation functional used in our study and conclude that large-spin canting is a promising property of the postperovskite fluoride compounds. [less ▲]

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See detailLe diabete du sujet age: du defi epidemiologique a une approche personnalisee.
Scheen, André ULg; Paquot, Nicolas ULg; Bauduceau, B.

in Revue medicale de Liege (2014), 69(5-6), 323-8

Diabetes mellitus is a common chronic disease in the elderly, being either a known disease with a long history (type 1 or even more often type 2 diabetes) and then frequently associated with various ... [more ▼]

Diabetes mellitus is a common chronic disease in the elderly, being either a known disease with a long history (type 1 or even more often type 2 diabetes) and then frequently associated with various diabetic complications, or a recently diagnosed diabetes that may, however, have been ignored for a rather long time. In this latter case, diabetes may present as the occurrence or aggravation of one or several geriatric syndromes that overall result in a loss of autonomy. The global geriatric assessment, the estimation of life expectancy and the justification of glucose-lowering treatments should be performed at regular intervals in elderly diabetic people as they determine the right choice of glucose target levels and the best selection of glucose-lowering agents. Medications that can induce hypoglycaemia should ideally be avoided, especially in the frailty older population. The benefit-risk ratio of the proposed therapies should be analyzed first, and then regularly reassessed because of a potentially rapidly progressing condition. The recommended approach is a tailored management of diabetes that should integrate the clinical, functional and psycho-social aspects of elderly individuals. [less ▲]

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See detailFrom taboo to commodity: history and current situation of cavy culture in the Democratic Republic of the Congo
Maass; Metre, TK; Tsongo, F et al

in Livestock Research for Rural Development (2014), 26

For the first time, the status of cavy culture in the Democratic Republic of the Congo (DRC) is reviewed with emphasis on Sud-Kivu province. Cavy culture, as discussed in this paper, is the raising ... [more ▼]

For the first time, the status of cavy culture in the Democratic Republic of the Congo (DRC) is reviewed with emphasis on Sud-Kivu province. Cavy culture, as discussed in this paper, is the raising, production and utilization of the domestic cavy (i.e., Guinea pig, Cavia porcellus) for consumption. Many sources were used in the review, but published scientific research literature is extremely scarce. Nevertheless, it can be estimated that more than 2 million cavies are kept in DRC, contributing significantly to nutrition security, especially animal protein, and income generation of some hundreds of thousands of poor rural and urban households. The largest cavy populations are in the Kivu provinces, which is probably partly due to the inclusion of cavies in ‘rehabilitation kits’ of humanitarian NGOs and in the agricultural portfolio of development agencies who seek to address the challenges of widespread hunger and malnutrition in the area. The review covers the history of cavy culture in Sud-Kivu since colonial times based on oral tradition; it describes the current ‘cavy status’ in the country and identifies research and capacity building needs. We suggest that cavy culture in DRC is likely to become more widespread and important due to the activities of a new project on ‘Harnessing husbandry of domestic cavy for alternative and rapid access to food and income in Cameroon and the eastern Democratic Republic of the Congo’. Given the dimension, cavies should be included in livestock census as well as research and development agenda, honoring their role in the livelihoods of less endowed people, especially women. [less ▲]

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See detailFaites vos jeux, rien ne va plus ... la peau a l'age de la retraite, aujourd'hui et demain.
Pierard, Gérald ULg; Lesuisse, M.; Saint-Leger, D. et al

in Revue medicale de Liege (2014), 69(5-6), 366-71

Senescence of people represents a global expression of obsolescence of their organs, tissues, cells and constitutive molecules. Skin, similarly to any other organ, is ageing in particular ways. Over the ... [more ▼]

Senescence of people represents a global expression of obsolescence of their organs, tissues, cells and constitutive molecules. Skin, similarly to any other organ, is ageing in particular ways. Over the past century, the time effects on skin have been expressed differently. Skin of any individual presently engaged in the Third Age looks different from that of his/her line ancestral. What is the expected future? The Third Age population is expanding and skin problems call for a variety of management procedures. Prevention of the diverse types of skin ageing has made tremendous progresses particularly in the field of preventive and corrective dermocosmetology. The future should further speed up such trends. [less ▲]

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See detailThe role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women : A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Rizzoli, R; Stevenson, JC; Bauer, JM et al

in Maturitas (2014), 79

From 50 years of age, postmenopausal women are at an increased risk of developing sarcopenia and osteoporosis as a result of deterioration of musculoskeletal health. Both disorders increase the risk of ... [more ▼]

From 50 years of age, postmenopausal women are at an increased risk of developing sarcopenia and osteoporosis as a result of deterioration of musculoskeletal health. Both disorders increase the risk of falls and fractures. The risk of developing sarcopenia and osteoporosis may be attenuated through healthy lifestyle changes, which include adequate dietary protein, calcium and vitamin D intakes, and regular physical activity/exercise, besides hormone replacement therapy when appropriate. Protein intake and physical activity are the main anabolic stimuli for muscle protein synthesis. Exercise training leads to increased muscle mass and strength, and the combination of optimal protein intake and exercise produces a greater degree of muscle protein accretion than either intervention alone. Similarly, adequate dietary protein intake and resistance exercise are important contributors to the maintenance of bone strength. Vitamin D helps to maintain muscle mass and strength as well as bone health. These findings suggest that healthy lifestyle measures in women aged >50 years are essential to allow healthy ageing. The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) recommends optimal dietary protein intake of 1.0–1.2 g/kg body weight/d with at least 20–25 g of high-quality protein at each main meal, with adequate vitamin D intake at 800 IU/d to maintain serum 25-hydroxyvitamin D levels >50 nmol/L as well as calcium intake of 1000 mg/d, alongside regular physical activity/exercise 3–5 times/week combined with protein intake in close proximity to exercise, in postmenopausal women for prevention of age-related deterioration of musculoskeletal health. [less ▲]

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See detailLes indicateurs de la pression du cerf élaphe sur la végétation du sous-bois en forêts feuillues tempérées : synthèse bibliographique
Lehaire, François ULg; Ligot, Gauthier ULg; Morelle, Kevin ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 262-272

During the last decades, the populations of large herbivores have increased. Consequently, their pressure on forest vegetation has been exacerbated and has reached in some forests levels that reduced the ... [more ▼]

During the last decades, the populations of large herbivores have increased. Consequently, their pressure on forest vegetation has been exacerbated and has reached in some forests levels that reduced the diversity of forest ecosystem services. Assessing the balance between timber production and hunting remains a crucial question for forest users (foresters, hunters) and requires reliable tools such as ecological indicators. This paper reviews the ecological indicators that characterize the pressure of red deer (Cervus elaphus L.) on understory vegetation in temperate deciduous forest. Such indicators monitor the cover, height, stem density, biomass and species diversity of different indicator plant groups. These plant groups embrace species belonging to herbaceous stratum, forest regeneration or particular species such as bilberry (Vaccinium myrtillus L.) and bramble (Rubus fruticosus L.). The choice of indicator plants, as it affects considerably the performance of the ecological indicator of deer pressure on understory vegetation, must be carried out with caution taking into account plant abundance and palatability. The reviewed indicators help to understand the relationships between biodiversity, carrying capacity and deer populations. They are intended to forest managers that would like to monitor red deer pressure in regards to forest management goals and forest sustainability. [less ▲]

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See detailInterdisciplinary approaches to the phenomenology of auditory verbal hallucinations
Woods, A; Jones, N; Bernini, M et al

in Schizophrenia Bulletin (2014), 40

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See detailMycosubtilin and surfactin are efficient, low ecotoxicity molecules for the biocontrol of lettuce downy mildew.
Deravel, Jovana; Lemiere, Sebastien; Coutte, Francois et al

in Applied microbiology and biotechnology (2014), 98(14), 6255-64

The use of surfactin and mycosubtilin as an eco-friendly alternative to control lettuce downy mildew caused by the obligate pathogen Bremia lactucae was investigated. Preliminary ecotoxicity evaluations ... [more ▼]

The use of surfactin and mycosubtilin as an eco-friendly alternative to control lettuce downy mildew caused by the obligate pathogen Bremia lactucae was investigated. Preliminary ecotoxicity evaluations obtained from three different tests revealed the rather low toxicity of these lipopeptides separately or in combination. The EC50 (concentration estimated to cause a 50 % response by the exposed test organisms) was about 100 mg L(-1) in Microtox assays and 6 mg L(-1) in Daphnia magna immobilization tests for mycosubtilin and 125 mg L(-1) and 25 mg L(-1) for surfactin, respectively. The toxicity of the mixture mycosubtilin/surfactin (1:1, w/w) was close to that obtained with mycosubtilin alone. In addition, the very low phytotoxic effect of these lipopeptides has been observed on germination and root growth of garden cress Lepidium sativum L. While a surfactin treatment did not influence the development of B. lactucae on lettuce plantlets, treatment with 100 mg L(-1) of mycosubtilin produced about seven times more healthy plantlets than the control samples, indicating that mycosubtilin strongly reduced the development of B. lactucae. The mixture mycosubtilin/surfactin (50:50 mg L(-1)) gave the same result on B. lactucae development as 100 mg L(-1) of mycosubtilin. The results of ecotoxicity as well as those obtained in biocontrol experiments indicated that the presence of surfactin enhances the biological activities of mycosubtilin. Mycosubtilin and surfactin were thus found to be efficient compounds against lettuce downy mildew, with low toxicity compared to the toxicity values of chemical pesticides. This is the first time that Bacillus lipopeptides have been tested in vivo against an obligate pathogen and that ecotoxic values have been given for surfactin and mycosubtilin. [less ▲]

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See detailRelation Between Indoor Thermal Environment and Renovation in Liege Residential Buildings
Singh, Manoj Kumar; Mahapatra, Sadhan; Teller, Jacques ULg

in Thermal Science (2014), 18(3), 889-902

Indoor thermal environment monitoring has been done in 20 residential buildings of Liege city followed by questionnaire based comfort survey amongst the occu- pants of 85 houses in order to record their ... [more ▼]

Indoor thermal environment monitoring has been done in 20 residential buildings of Liege city followed by questionnaire based comfort survey amongst the occu- pants of 85 houses in order to record their preference and expectations about in- door thermal environment in winter and spring season. It is found from the anal- ysis that change of glazing has a minimum or even sometimes an adverse effect on the existing indoor environment due to the absence of proper insulation of the rest of the building envelope. It is observed that in winter there is a sudden drop in indoor temperature and also overheating in summer. This is due to unplanned installation of glazing which actually increases the fenestration area ratio lead- ing to higher indoor temperature fluctuation and causes discomfort. It is also im- portant that the occupant’s preference and expectations as well as overall as- sessment of indoor environment needs to be consider towards energy efficiency improvement. [less ▲]

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See detailDeterminants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.
Voilliot, Damien; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014)

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the ... [more ▼]

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. METHODS AND RESULTS: We prospectively enrolled 63 patients with SSc (age 54+/-3years, 76% female) followed in CHU Sart-Tilman in Liege. All patients underwent graded semi-supine exercise echocardiography. Systolic pulmonary arterial pressure (sPAP) was derived from the peak velocity of the tricuspid regurgitation jet and adding the estimation of right atrial pressure, both at rest and during exercise. Resting pulmonary arterial hypertension (PH) was defined as sPAP >35mmHg and EIPH as sPAP >50mmHg during exercise. The following formulas were used: mean PAP (mPAP)=0.61xsPAP+2, left atrial pressure (LAP)=1.9+1.24xleft ventricular (LV) E/e' and pulmonary vascular resistance (PVR)=(mPAP-LAP)/LV cardiac output (CO) and slope of mPAP-LVCO relationship=changes in mPAP/changes in LVCO. Resting PH was present in 3 patients (7%) and 21 patients developed EIPH (47%). Patients with EIPH had higher resting LAP (10.3+/-2.2 versus 8.8+/-2.3mmHg; p=0.03), resting PVR (2.6+/-0.8 vs. 1.4+/-1.1Woods units; p=0.004), exercise LAP (13.3+/-2.3 vs. 9+/-1.7mmHg; p<0.0001), exercise PVR (3.6+/-0.7 vs. 2.1+/-0.9 Woods units; p=0.02) and slope of mPAP-LVCO (5.8+/-2.4 vs. 2.9+/-2.1mmHg/L/min; p<0.0001). After adjustment for age and gender, exercise LAP (beta=3.1+/-0.8; p=0.001) and exercise PVR (beta=7.9+/-1.7; p=0.0001) were independent determinants of exercise sPAP. CONCLUSION: EIPH is frequent in SSc patients and is mainly related to both increased exercise LV filling pressure and exercise PVR. [less ▲]

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See detailOsteonecrosis of the jaw in a male osteoporotic patient treated with denosumab
NEUPREZ, Audrey ULg; Coste, S; Rompen, Eric ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the ... [more ▼]

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk. [less ▲]

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See detailPrediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery.
Caradec, Thibault; Pupin, Maude; Vanvlassenbroeck, Aurelien et al

in PloS one (2014), 9(1), 85667

Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide ... [more ▼]

Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide Synthetases (NRPSs), they often display complex structures with cycles and branches. Moreover they often contain non proteogenic or modified monomers, such as the D-monomers produced by epimerization. We investigate here some sequence specificities of the condensation (C) and epimerization (E) domains of NRPS that can be used to predict the possible isomeric state (D or L) of each monomer in a putative peptide. We show that C- and E- domains can be divided into 2 sub-regions called Up-Seq and Down-Seq. The Up-Seq region corresponds to an InterPro domain (IPR001242) and is shared by C- and E-domains. The Down-Seq region is specific to the enzymatic activity of the domain. Amino-acid signatures (represented as sequence logos) previously described for complete C-and E-domains have been restricted to the Down-Seq region and amplified thanks to additional sequences. Moreover a new Down-Seq signature has been found for Ct-domains found in fungi and responsible for terminal cyclization of the peptides. The identification of these signatures has been included in a workflow named Florine, aimed to predict nonribosomal peptides from NRPS sequence analyses. In some cases, the prediction of isomery is guided by genus-specific rules. Florine was used on a Pseudomonas genome to allow the determination of the type of pyoverdin produced, the update of syringafactin structure and the identification of novel putative products. [less ▲]

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See detailPharmacokinetics in patients with chronic liver disease and hepatic safety of incretin-based therapies for the management of type 2 diabetes mellitus.
Scheen, André ULg

in Clinical pharmacokinetics (2014), 53(9), 773-85

Patients with type 2 diabetes mellitus have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis, and about one-third of cirrhotic patients have ... [more ▼]

Patients with type 2 diabetes mellitus have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis, and about one-third of cirrhotic patients have diabetes. However, the use of several antidiabetic agents, such as metformin and sulphonylureas, may be a concern in case of hepatic impairment (HI). New glucose-lowering agents targeting the incretin system are increasingly used for the management of type 2 diabetes. Incretin-based therapies comprise oral inhibitors of dipeptidyl peptidase-4 (DPP-4) (gliptins) or injectable glucagon-like peptide-1 (GLP-1) receptor agonists. This narrative review summarises the available data regarding the use of both incretin-based therapies in patients with HI. In contrast to old glucose-lowering agents, they were evaluated in specifically designed acute pharmacokinetic studies in patients with various degrees of HI and their hepatic safety was carefully analysed in large clinical trials. Only mild changes in pharmacokinetic characteristics of DPP-4 inhibitors were observed in patients with different degrees of HI, presumably without major clinical relevance. GLP-1 receptor agonists have a renal excretion rather than liver metabolism. Specific pharmacokinetic data in patients with HI are only available for liraglutide. No significant changes in liver enzymes were reported with DPP-4 inhibitors or GLP-1 receptor agonists, alone or in combination with various other glucose-lowering agents, in clinical trials up to 2 years in length. On the contrary, preliminary data suggested that incretin-based therapies may be beneficial in patients with CLD, more particularly in the presence of non-alcoholic fatty liver disease. Nevertheless, caution should be recommended, especially in patients with advanced cirrhosis, because of a lack of clinical experience with incretin-based therapies in these vulnerable patients. [less ▲]

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See detailCharacterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogel
Haghgoo, Majid; Yousefi, Ali Akbar; Zohouriaan Mehr, Mohammad Jalal et al

in Microporous and Mesoporous Materials (2014), 184

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See detailFirst isolation and molecular characterization of foot-and-mouth disease virus in Benin
Gorna, K; Houndjè, E; Romey, A et al

in Veterinary Microbiology (2014)

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See detailDevice-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation
Krier, Fabrice ULg; Riva, Raphaël ULg; Defrère, Sylvie et al

in Journal of Drug Delivery Science and Technology [=JDDST] (2014), 24(2), 198-204

Local treatment using drug loaded implants allows decreasing seric concentrations of the active ingredient with the purpose of limiting side effects and reaching perfect observance. Nowadays, some ... [more ▼]

Local treatment using drug loaded implants allows decreasing seric concentrations of the active ingredient with the purpose of limiting side effects and reaching perfect observance. Nowadays, some diseases are already treated with implants, but generally, by subcutaneous or intra vaginal implantation. In this work, a new implant device dedicated to the intra-peritoneal cavity was developed. For this purpose, a core-membrane polymer implant was selected. We propose an original method to determine the most appropriate membrane to control the release based on the use of Franz cells. The ability of the implant to release a constant quantity of an active ingredient will be assessed by testing implants in vitro. Finally, intra peritoneal cavity and subcutaneous in vivo implantation has been achieved in order to confirm the controlled and local release of the active ingredient. [less ▲]

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See detailINDICATIONS D’UN TRAITEMENT DE RADIOTHERAPIE LOCALE APRES PROSTATECTOMIE RADICALE
HERMESSE, Johanne ULg; WERENNE, Xavier ULg; PHILIPPI, Sven ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 29-31

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See detailProduction of dissolved organic matter by phytoplankton and its uptake by heterotrophic prokaryotes in large tropical lakes
Morana, Cédric; Sarmento, Hugo; Descy, Jean-Pierre et al

in Limnology & Oceanography (2014), 59(4), 1364-1375

In pelagic ecosystems, phytoplankton extracellular release can extensively subsidize the heterotrophic prokaryotic carbon demand. Time-course experiments were carried out to quantify primary production ... [more ▼]

In pelagic ecosystems, phytoplankton extracellular release can extensively subsidize the heterotrophic prokaryotic carbon demand. Time-course experiments were carried out to quantify primary production, phytoplankton excretion, and the microbial uptake of freshly released dissolved organic carbon (DOC) derived from phytoplankton extracellular release (DOCp) in four large tropical lakes distributed along a productivity gradient: Kivu, Edward, Albert, and Victoria. The contributions of the major heterotrophic bacterial groups to the uptake of DOCp was also analyzed in Lake Kivu, using microautoradiography coupled to catalyzed reporter deposition fluorescent in situ hybridization. The percentage of extracellular release (PER) varied across the productivity gradient, with higher values at low productivity. Furthermore, PER was significantly related to high light and low phosphate concentrations in the mixed layer and was comparatively higher in oligotrophic tropical lakes than in their temperate counterparts. Both observations suggest that environmental factors play a key role in the control of phytoplankton excretion. Standing stocks of DOCp were small and generally contributed less than 1% to the total DOC because it was rapidly assimilated by prokaryotes. In other words, there was a tight coupling between the production and the heterotrophic consumption of DOCp. None of the major phylogenetic bacterial groups that were investigated differed in their ability to take up DOCp, in contrast with earlier results reported for standard labeled single-molecule substrates (leucine, glucose, adenosine triphosphate). It supports the idea that the metabolic ability to use DOCp is widespread among heterotrophic prokaryotes. Overall, these results highlight the importance of carbon transfer between phytoplankton and bacterioplankton in large African lakes. [less ▲]

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See detailIchthyosaurs from the French Rhaetian indicate a severe turnover across the Triassic–Jurassic boundary
Fischer, Valentin ULg; Cappetta, Henri; Vincent, Peggy et al

in Naturwissenschaften (Die) (2014)

Mesozoic marine reptiles went through a severe turnover near the end of the Triassic. Notably, an important extinction event affected ichthyosaurs, sweeping a large part of the group. This crisis is ... [more ▼]

Mesozoic marine reptiles went through a severe turnover near the end of the Triassic. Notably, an important extinction event affected ichthyosaurs, sweeping a large part of the group. This crisis is, however, obscured by an extremely poor fossil record and is regarded as protracted over the entire Norian–earliest Jurassic interval, for the lack of a more precise scenario. The iconic whale-sized shastasaurid ichthyosaurs are regarded as early victims of this turnover, disappearing by the middle Norian. Here we evaluate the pattern of this turnover among ichthyosaurs by analysing the faunal record of two Rhaetian localities. One locality is Autun, eastern France; we rediscovered in this material the holotypes or partial ‘type’ series of Rachitrema pellati, Actiosaurus gaudryi, Ichthyosaurus rheticus, Ichthyosaurus carinatus and Plesiosaurus bibractensis; a revised taxonomic scheme is proposed. The second assemblage comes from a new locality: Cuers, southeastern France. Both these assemblages provide several lines of evidence for the presence of shastasaurid-like ichthyosaurs in the Rhaetian of Europe. These occurrences suggest that both the demise of shastasaurids and the sudden radiation of neoichthyosaurians occurred within a short time window; this turnover appears not only more abrupt but also more complex than previously postulated and adds a new facet of the end-Triassic mass extinction [less ▲]

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See detailAssociative learning of Nasonia vitripennis Walker (Hymenoptera: Pteromalidae) to methyldisulfanylmethane
Frederickx, Christine ULg; Verheggen, François ULg; Brostaux, Yves ULg et al

in Journal of Forensic Sciences (2014)

Traditional methods of volatile detection used by police typically consist of reliance on canine olfaction. However, dogs have some limitations such as cost of training and time of conditioning. The ... [more ▼]

Traditional methods of volatile detection used by police typically consist of reliance on canine olfaction. However, dogs have some limitations such as cost of training and time of conditioning. The possibility of using parasitic wasps for detecting explosives and narcotics has been developed. Moreover, wasps are cheap to produce and can be conditioned with impressive speed for a specific chemical-detection task. We examined the ability of Nasonia vitripennis Walker to learn and respond to methydisulfanylmethane (DMDS), a volatile discriminator of cadaver. The training aimed to form an association between an unconditioned stimulus (pupae) and the conditioned stimulus (odor source). After the training, the time spent of conditioned wasps in the DMDS chamber was measured. Statistical analysis showed that the increasing concentrations involved an increase in the time spent in the chamber containing DMDS. This study indicates that N. vitripennis can respond to DMDS, which provide further support for its development as a biological sensor. [less ▲]

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See detailThe freeness problem over matrix semigroups and bounded languages
Charlier, Emilie ULg; Honkala, Juha

in Information & Computation (2014), 237

We study the freeness problem for matrix semigroups. We show that the freeness problem is decidable for upper-triangular 2 × 2 matrices with rational entries when the products are restricted to certain ... [more ▼]

We study the freeness problem for matrix semigroups. We show that the freeness problem is decidable for upper-triangular 2 × 2 matrices with rational entries when the products are restricted to certain bounded languages. [less ▲]

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See detailLong-term fracture rates seen with continued ibandronate treatment : pooled analysis of DIVA and MOBILE long-term extension studies
Miller, PD; Recker, RR; Harris, S et al

in Osteoporosis International (2014), 25(1), 349-357

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See detailSurprising causes of C5-carnitine false positive results in newborn screening.
BOEMER, François ULg; SCHOOS, Roland ULg; de HALLEUX, Virginie ULg et al

in Molecular genetics and metabolism (2014), 111(1), 52-4

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we ... [more ▼]

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we confirmed the presence of pivaloylcarnitine. Exogenous pivalate administration had been previously identified as the causal agent of this concern. No pivalic-ester prodrug is commercially available in Belgium, but pivalic derivates are also used in the cosmetic industry as emollient under the term "neopentanoate". We have identified neopentanoate-esters in a nipple-fissure unguent that was provided to young mothers. Ceasing distribution of this product hugely reduced the C5-carnitine false positivity rate. [less ▲]

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See detailPortrait photographique d’écrivain et newsmagazine. Pour une approche rhétorique de l’événementialité du littéraire
Provenzano, François ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2014), 14

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See detailUltrathin porous pavement made with high viscosity asphalt rubber binder: A better acoustic absorption?
Luong, Jeanne ULg; Bueno, M.; Vazquez, V.F. et al

in Applied Acoustics (2014), 79

his work presents a non-destructive technique applied to ultrathin porous asphalt pavements that allows us to characterize their internal structure. Comparison between acoustic absorption data from ... [more ▼]

his work presents a non-destructive technique applied to ultrathin porous asphalt pavements that allows us to characterize their internal structure. Comparison between acoustic absorption data from experimental tests with an impedance tube and analytical simulation leads to an optimization of intrinsic parameters, such as tortuosity, airflow resistivity and porosity. The studied ultrathin specimens are of a high air void content porous mixture made with conventional polymer modified bituminous binder and high viscosity rubber binder. It has been found that one of the studied mixtures presents less air void con- tent than specified by the manufacturer, and thus absorbs less noise as foreseen. Finally, in this case it appears that using a high viscosity asphalt rubber binder has no influence on maximum acoustic absorp- tion but on the frequency of appearance of this maximum, tortuosity and airflow resistivity. [less ▲]

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See detailGenetic analysis of pig survival up to commercial weight in a crossbred population
Dufrasne, Marie ULg; Misztal, Ignacy; Tsuruta, Shogo et al

in Livestock Science (2014), 167

Records from 99,384 crossbred pigs from Duroc sires and Large White x Landrace dams were used to estimate genetic parameters for survival traits at different stages of the fattening period, and their ... [more ▼]

Records from 99,384 crossbred pigs from Duroc sires and Large White x Landrace dams were used to estimate genetic parameters for survival traits at different stages of the fattening period, and their relations with final weight. Traits analyzed were preweaning mortality (PWM), culling between weaning and harvesting (Call), culling during the farrowing period (Cfar), in the nursery site (Cnur), during the finishing phase (Cfin), and hot carcass weight (HCW). Because of the binary nature of PWM and culling traits, threshold-linear models were used: Model 1, including PWM, Call, and HCW; Model 2, including PWM, Cfar, Cnur, Cfin, and HCW. Both models included sex and parity number as fixed effects for all traits. Contemporary groups were considered as fixed effect for HCW and as random effects for the binary traits. Random effects were sire additive genetic, common litter, and residual effects for all traits and models. Heritability estimates were 0.03 for PWM, and 0.15 for HCW with both models, 0.06 for Call with Model 1, and 0.06 for Cfar, 0.14 for Cnur, and 0.10 for Cfin with Model 2. Litter variance explained a large part of the total variance and its influence declined slightly with age. For Model 1, genetic correlations were -0.36 between PWM and Call, -0.02 between PWM and HCW, and -0.25 between Call and HCW; correlations for litter effect were -0.15 between PWM and Call, -0.19 between PWM and HCW, and -0.21 between Call and HCW. For Model 2, genetic correlations were all positive between PWM and culling traits, except between PWM and Cnur (-0.61). Genetic correlations between HCW and the other traits were moderate and negative to null. Correlations for common litter effect were all negative between traits, except between Cfar and Cfin, and between Cnur and Cfin. Heritability of PWM and culling traits increased with age period. Therefore, selection for survival after weaning may be more efficient. The low genetic correlations between PWM and culling traits suggest that different genes influence pre- and postweaning mortality. The HCW was not correlated with the other traits. However, relationships are not strongly unfavorable, therefore selection for survival and high final weight is possible. [less ▲]

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See detailThe self-report Version of the LSAS-CA: Psychometric Properties of the French Version in a non-clinical adolescent sample
Schmits, Emilie ULg; Heeren, Alexandre; Quertemont, Etienne ULg

in Psychologica Belgica (2014), 54(2), 181-198

The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The ... [more ▼]

The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The psychometric properties of the self-report version of the LSAS-CA (LSAS-CA-SR) have been investigated in a Spanish population. However, no study to date has adapted and validated this scale in French. The purpose of this study was to develop a French version of the LSAS-CA-SR and to assess its score reliability and structural validity in a French-speaking community sample. The sample was made up of 1,343 teenagers from secondary schools, aged between 14 and 18 years. Confirmatory factor analyses established the structural validity of the French version of the LSAS-CA-SR and good psychometric properties, including reliable internal consistency, were observed. [less ▲]

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See detailExercise Testing and Stress Imaging in Valvular Heart Disease.
henri, Christine; Pierard, Luc ULg; Lancellotti, Patrizio ULg et al

in The Canadian journal of cardiology (2014), 30(9), 1012-1026

The role of exercise testing and stress imaging in the management of patients with valvular heart disease (VHD) is reviewed in this article. The American College of Cardiology/American Heart Association ... [more ▼]

The role of exercise testing and stress imaging in the management of patients with valvular heart disease (VHD) is reviewed in this article. The American College of Cardiology/American Heart Association and the European Society of Cardiology/European Association of Cardiothoracic Surgery have recently put emphasis on the role of exercise testing to clarify symptom status and the use of stress imaging to assess the dynamic component of valvular abnormalities and unmask subclinical myocardial dysfunction that could be missed at rest. Recent studies have demonstrated the incremental prognostic value of exercise echocardiography for asymptomatic patients with severe aortic stenosis, moderate-severe mitral stenosis, and severe primary mitral regurgitation. In patients with low-flow, low-gradient aortic stenosis, dobutamine stress echocardiography is recommended to differentiate true severe from pseudosevere aortic stenosis. Data on the prognostic value of stress echocardiography in aortic regurgitation and functional mitral regurgitation are less robust. Data are sparse on the use of stress imaging in right-sided VHD, however recent studies using stress cardiovascular magnetic resonance imaging offer some prognostic information. Although the strongest recommendations for surgical treatment continue to be based on symptom status and resting left ventricular repercussions, stress imaging can be useful to optimize risk stratification and timing of surgery in VHD. Randomized clinical trials are required to confirm that clinical decision-making based on stress imaging can lead to improved outcomes. [less ▲]

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See detailUse of sapropterin dihydrochloride in maternal phenylketonuria. A European experience of eight cases.
Feillet, Francois; Muntau, Ania C.; DEBRAY, François-Guillaume ULg et al

in Journal of inherited metabolic disease (2014)

Sapropterin dihydrochloride (SD) is the first drug treatment for phenylketonuria (PKU), but due to the lack of data, its use in maternal PKU must be undertaken with caution as noted in the FDA and EMEA ... [more ▼]

Sapropterin dihydrochloride (SD) is the first drug treatment for phenylketonuria (PKU), but due to the lack of data, its use in maternal PKU must be undertaken with caution as noted in the FDA and EMEA labels. We collected data from eight pregnancies in PKU women treated with SD and we analysed the phenotypes of these patients, their tetrahydrobiopterin (BH4) responsiveness, the indications for SD treatment, the efficacy (metabolic control, phenylalanine (Phe) tolerance and offspring outcome) and the safety data. Results showed that in the seven patients known to be responsive to BH4, the use of SD during pregnancy was efficient in terms of metabolic control and Phe tolerance. The indications for giving SD included the failure of the low-Phe diet (n = 3), the fact that some of these women had never experienced the low Phe diet (n = 2), one unexpected pregnancy in a woman currently on SD and one pregnancy where the foetus was known to have PKU. The offspring of these seven pregnancies were all normal babies with normal birth measurements and outcomes. No side effect related to SD was observed in these seven cases. In the eighth case, SD was prescribed as a rescue treatment without previous knowledge of the BH4 responsiveness to a woman who was already 8 weeks pregnant without diet. The birth occurred at 33 weeks of gestational age with Potter syndrome (probably related to the absence of metabolic control during the first trimester) and the baby died in the first hours of life. In conclusion, the data presented here provides the first evidence that treatment with pharmacological doses of SD appears to be efficient and safe in women with PKU during pregnancy. Its use should, however, be restricted to those women previously identified to be clear responders to BH4. [less ▲]

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See detailUn complexe d’espèces d’Afzelia des forêts africaines d’intérêt économique et écologique (synthèse bibliographique)
Donkpegan, Segbedji ULg; Hardy, J. Olivier; Lejeune, Philippe ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2),

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The ... [more ▼]

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The distribution of Afzelia species in Africa suggests that the tree has made various adaptations due to ecological factors. However, on the basis of only vegetative criteria, it is difficult to distinguish species in forest inventory, and this could compromise the sustainable management approach promoted by the populations of Central African countries. We show that the genus remains generally understudied, although some of its species are considered by the IUCN as being under threat. Therefore, the ecological and genetic aspects of our investigations should prove relevant to the future cultivation of Afzelia. [less ▲]

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See detailImpact of purification and fractionation process on the chemical structure and physical properties of locust bean gum
Gillet, Sébastien ULg; Blecker, Christophe ULg; Aguedo, Mario ULg et al

in Carbohydrate Polymers (2014)

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on ... [more ▼]

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on the residual impoverished fraction (GM80). The complete structural characterization has shown that GM80 possessed relatively longer chain lengths than GM25, a slightly lower degree of galactose substitution and a somewhat sharper galactosyl distribution in substituted and unsubstituted regions. A physical behavior analysis was carried out on solubilization kinetics, viscosity, viscoelasticity and formation of associated gels with xanthan or carrageenan. The average structure of GM80 generated larger intra-chain, inter-chain and inter-molecular interactions, resulting in the appearance of a stronger network. Small structural differences therefore generated very different physical behaviors. This study thus allowed to establish, in a precise and complete manner, fractionation-purification-structure-function relationships of galactomannans extracted from carob. [less ▲]

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See detailPhysical and biological controls on DMS,P dynamics in ice-shelf influenced fast ice during a winter-spring and a spring-summer transitions
Carnat, G.; Zhou, Jiayun ULg; Papakyriakou, T. et al

in Journal of Geophysical Research. Oceans (2014), 119

We report the seasonal and vertical variations of dimethylsulphide (DMS) and its precursor dimethylsulfoniopropionate (DMSP) in fast ice at Cape Evans, McMurdo Sound (Antarctica) during the spring-summer ... [more ▼]

We report the seasonal and vertical variations of dimethylsulphide (DMS) and its precursor dimethylsulfoniopropionate (DMSP) in fast ice at Cape Evans, McMurdo Sound (Antarctica) during the spring-summer transition in 2011 and winter-spring transition in 2012. We compare the variations of DMS,P observed to the seasonal evolution of the ice algal biomass and of the physical properties of the ice cover, with emphasis on the ice texture and brine dynamics. Isolated DMS and DMSP maxima were found during both seasonal episodes in interior ice and corresponded to the occurrence of platelet crystals in the ice texture. We show that platelet crystals formation corresponded in time and depth to the incorporation of dinoflagellates (strong DMSP producers) in the ice cover. We also show that platelet crystals could modify the environmental stresses on algal cells and perturb the vertical redistribution of DMS,P concentrations. We show that during the winter-spring transition in 2012, the DMS,P profiles were strongly influenced by the development and decline of a diatom dominated bloom in the bottom ice, with DMSP variations remarkably following chl a variations. During the spring-summer transition in 2011, the increase in brine volume fraction (influencing ice permeability) on warming was shown to trigger (1) an important release of DMS to the under-ice water through brine convection (2) a vertical redistribution of DMSP across the ice [less ▲]

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See detailRole of larval host plant experience and solanaceous plant volatile emissions in Tuta absoluta (Lepidoptera: Gelechiidae) host finding behavior
Caparros Megido, Rudy ULg; De Backer, Lara; Ettaïb, Refki et al

in Arthropod-Plant Interactions (2014)

The tomato leafminer, Tuta absoluta (Lepi- doptera: Gelechiidae), is considered to be a major pest that damages tomato (Solanum lycopersicum L; Solanaceae) crops in South American, European, and ... [more ▼]

The tomato leafminer, Tuta absoluta (Lepi- doptera: Gelechiidae), is considered to be a major pest that damages tomato (Solanum lycopersicum L; Solanaceae) crops in South American, European, and Mediterranean countries. This insect species is polyphagous (i.e., feeds on many types of food); hence, it could also develop on other cultivated host plants, principally solanaceous plants, such as potato (S. tuberosum L.; Solanaceae) and eggplant (S. melongena L.; Solanaceae). Therefore, we tested the hypothesis that host plant choice by adult T. absoluta is influenced by plant volatile organic compounds and larval host plant experience. One tomato cultivar (cv.) ‘Money- maker’ and three potato cv. ‘Charlotte’ ‘Bintje,’ and ‘Nicola’ were tested. Using a flying tunnel, we observed that females reared on tomato preferred flying toward tomato and, to a lesser extent, potato cv. ‘Charlotte.’ These preferences might be explained by the high release of terpenes by these two plants. When conducting oviposition choice assays, we found no preference between tomato and potato in the number of eggs laid by females that had been previously reared on either host plant. This study indicates that the host finding behavior of T. absoluta is mediated by solanaceous volatiles, while oviposition behavior appears to depend on additional stimuli. These results provide baseline information for use in the development of new control strategies against T. absoluta using semiochemicals and plant breeding. [less ▲]

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See detailPlant defense stimulation by natural isolates of Bacillus depends on efficient surfactin production
Cawoy, Hélène ULg; Mariutto, Martin; Henry, Guillaume et al

in Molecular Plant-Microbe Interactions [=MPMI] (2014), 27

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See detailResistance of through-plate component in beam-to-column joints with circular hollow columns
Hoang, Van Long ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (2014), 92

A configuration of beam-to-column joint with circular hollow section columns is proposed. A vertical plate, called through-plate, passing through the column is used to support the beams. In order to ... [more ▼]

A configuration of beam-to-column joint with circular hollow section columns is proposed. A vertical plate, called through-plate, passing through the column is used to support the beams. In order to facilitate connecting the beams, two horizontal plates, each side of the column, are welded to the upper side of the through-plate. The lower flanges of the steel beams are connected to the horizontal plates by bolts, and the upper flanges are attached to the concrete slab by shear connections. The joint is considered as hinges in the construction phase while semi-rigid and partial strength can be adopted for the joint behaviour during the exploitation time. A development on the through-plate component of the joint is presented in this paper. Global behaviour of the joint under hogging moment and shear force is analysed leading to a mechanical model of the through-plate component. Using the elastic buckling theory of plates, the analytical formulas for critical stresses of the through-plate are obtained. The coefficients taking into account boundary conditions, material plasticity and geometrical imperfection are determined by finite element analysis. The proposed model is validated by experimental results showing a good accuracy. The design guideline for the component is finally provided for the practical purpose. [less ▲]

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See detailDioxins and polychlorinated biphenyls contamination in poultry liver related to food safety - A review
Ghimpeteanu, Oana-Margarita; Militaru, Manuella; Scippo, Marie-Louise ULg

in Food Control (2014), 38

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated ... [more ▼]

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants with high chemical stability; they are lipophilic compounds and they are not destroyed by microbial, photochemical, chemical or thermal degradation. Dioxins and PCBs are ubiquitous environmental contaminants, which are present in all marine plant and animals, birds, mammals and humans and bioaccumulate through the food chain. In the last years, there has been concern regarding food contamination with different chemical substances and their effect on food safety. More particularly, at the end of the 20th and the beginning of the 21st century, there were a series of incidents related to dioxin and PCBs, which directly affected human or contaminated the soil and accumulated in feed and then in food products, such as poultry liver. It was shown in case of dioxin incident that tetra and penta-chlorinated congeners (the most toxic ones) accumulates selectively in poultry livers. Maximal concentrations have been fixed in the European legislation for dioxins and PCBs in food from animal origin, in order to protect the consumer. Data about background poultry liver contamination are scarce and the few available show levels below the legal limit for dioxins, but data are still lacking for DL-PCBs. [less ▲]

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See detailReview of: D. Zahavi (ed.), The Oxford Handbook of Contemporary Phenomenology (Oxford, 2012)
Seron, Denis ULg

in Husserl Studies (2014), 30(2), 277-281

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See detailRADIOTHÉRAPIE MAMMAIRE- pret-à-porter ou sur mesure ?
COUCKE, Philippe ULg; LAKOSI, Ferenc ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 81-86

La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très ... [more ▼]

La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très bien codifiée et peut être taxée de «prêt-à-porter». Et pourtant, on est en droit de se poser la question s’il est possible de concevoir des indications de traitement «sur mesure». A ce jour, les données de la littéra - ture nous incitent à la prudence. Dans aucun cas de figure, on n’a été capable de démontrer que la radiothérapie pouvait être éliminée de l’approche thérapeutique sans pour autant risquer une augmentation significative du taux de rechute locale. Même si on considère que la radiothérapie adjuvante est une approche standard après une chirurgie conservatrice, il n’en reste pas moins qu’il persiste un certain nombre de questions ouvertes. Ces traitements actiniques pourraient être modulables en fonction des caractéristiques des patientes et des tumeurs. Idéalement, nous aimerions disposer de mar - queurs pronostiques et prédictifs robustes afin de détermi - ner qui il faut soumettre à ce traitement adjuvant. Peut-être que des signatures géniques vont permettre de sélectionner les patientes. Ces signatures géniques ne font pas l’unanimité quant à leur réelle portée clinique [less ▲]

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See detailOptimization of a formic/acetic acid delignification treatment on beech wood and its influence on the structural characteristics of the extracted lignins
Simon, Mathilde; Brostaux, Yves ULg; Vanderghem, Caroline ULg et al

in Journal of Chemical Technology & Biotechnology (2014), 89(1), 128-136

Background In order to replace petrochemicals by bio-based lignin products in a lot of high value-added applications, a formic/acetic acid treatment was adapted to beech wood (Fagus sylvatica L.) for ... [more ▼]

Background In order to replace petrochemicals by bio-based lignin products in a lot of high value-added applications, a formic/acetic acid treatment was adapted to beech wood (Fagus sylvatica L.) for lignin extraction. Results Beech wood particles were delignified at atmospheric pressure by a formic acid/acetic acid/water mixture. Cooking time and temperature were optimized for delignification, pulp yield and 2-furfural concentration. Response surface design analysis revealed that delignification yield increased with cooking time and temperature. Conclusion The multi-criteria optimization of delignification was used to find the ideal cooking conditions (5h07 min, 104.2°C) which could be satisfactory for the maximization of delignification (70.5%) and pulp yield (58.7%) and, to a lesser extent, for the minimization of 2-furfural production. Treatment conditions were found to influence the chemical structure of extracted lignins. Cooking time and temperature influenced inversely lignin molecular weights. [less ▲]

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See detailContinuous glucose control in the ICU: report of a 2013 round table meeting.
Wernerman, Jan; Desaive, Thomas ULg; Finfer, Simon et al

in Critical care (London, England) (2014), 18(3), 226

Achieving adequate glucose control in critically ill patients is a complex but important part of optimal patient management. Until relatively recently, intermittent measurements of blood glucose have been ... [more ▼]

Achieving adequate glucose control in critically ill patients is a complex but important part of optimal patient management. Until relatively recently, intermittent measurements of blood glucose have been the only means of monitoring blood glucose levels. With growing interest in the possible beneficial effects of continuous over intermittent monitoring and the development of several continuous glucose monitoring (CGM) systems, a round table conference was convened to discuss and, where possible, reach consensus on the various aspects related to glucose monitoring and management using these systems. In this report, we discuss the advantages and limitations of the different types of devices available, the potential advantages of continuous over intermittent testing, the relative importance of trend and point accuracy, the standards necessary for reporting results in clinical trials and for recognition by official bodies, and the changes that may be needed in current glucose management protocols as a result of a move towards increased use of CGM. We close with a list of the research priorities in this field, which will be necessary if CGM is to become a routine part of daily practice in the management of critically ill patients. [less ▲]

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See detailValidation d’un test d’inhibition auprès d’enfants présentant un trouble déficitaire de l’attention avec/sans hyperactivité
Catale, Corinne ULg; Lejeune, Caroline ULg; Schmitz, Xavier ULg et al

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2014), 46(1), 66-72

The objective of this study was to assess the development of inhibition in 5-11 years old children with the “Stroop fruit” task (see Archibald & Kerns, 1999; Catale & Meulemans, 2005) and to examine the ... [more ▼]

The objective of this study was to assess the development of inhibition in 5-11 years old children with the “Stroop fruit” task (see Archibald & Kerns, 1999; Catale & Meulemans, 2005) and to examine the clinical value of this tool. 346 French-speaking children without any developmental disorders or learning disabilities were included in this study. A clinical group of 25 children with attention deficit and hyperactivity disorder was also assessed with this task. Developmental analyses on age groups show an enhancement of performance in the interference condition between 5 and 8 years old. Furthermore, results also show that the clinical group performed significantly less accurately that the control group for the interference condition, which confirms the clinical interest of this tool. [less ▲]

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See detailLe Fonds Hubert Nyssen à l'Université de Liège
Durand, Pascal ULg; Habrand, Tanguy ULg

in Histoires littéraires (2014), 58

Biographie croisée de l'écrivain et de l'éditeur Hubert Nyssen et présentation détaillée du Fonds d'archives déposé par lui au Centre d'Etude du Livre Contemporain de l'Université de Liège.

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See detailAppropriateness criteria for cardiovascular imaging use in clinical practice: a position statement of the ESC/EACVI taskforce.
Garbi, Madalina; Habib, Gilbert; Plein, Sven et al

in European heart journal cardiovascular Imaging (2014), 15(5), 477-182

There is a growing interest from the scientific community in the appropriate use of cardiovascular imaging techniques for diagnosis and decision making in Europe. To develop appropriateness criteria for ... [more ▼]

There is a growing interest from the scientific community in the appropriate use of cardiovascular imaging techniques for diagnosis and decision making in Europe. To develop appropriateness criteria for cardiovascular imaging use in clinical practice in Europe, a dedicated taskforce has been appointed by the European Society of Cardiology (ESC) and the European Association of Cardiovascular Imaging (EACVI). The present paper describes the appropriateness criteria development process. [less ▲]

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See detailNeonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3' end of FBN1 gene.
Jacquinet, Adeline ULg; Verloes, Alain; Callewaert, Bert et al

in European journal of medical genetics (2014), 57(5), 230-4

We report a 16-year-old girl with neonatal progeroid features and congenital lipodystrophy who was considered at birth as a possible variant of Wiedemann-Rautenstrauch syndrome. The emergence of ... [more ▼]

We report a 16-year-old girl with neonatal progeroid features and congenital lipodystrophy who was considered at birth as a possible variant of Wiedemann-Rautenstrauch syndrome. The emergence of additional clinical signs (marfanoid habitus, severe myopia and dilatation of the aortic bulb) lead to consider the diagnosis of the progeroid variant of Marfan syndrome. A de novo donor splice-site mutation (c.8226+1G>A) was identified in FBN1. We show that this mutation leads to exon 64 skipping and to the production of a stable mRNA that should allow synthesis of a truncated profibrillin-1, in which the C-terminal furin cleavage site is altered. FBN1 mutations associated with a similar phenotype have only been reported in four other patients. We confirm the correlation between marfanoid phenotype with congenital lipodystrophy and neonatal progeroid features (marfanoid-progeroid-lipodystrophy syndrome) and frameshift mutations at the 3' end of FBN1. This syndrome should be considered in differential diagnosis of neonatal progeroid syndromes. [less ▲]

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See detailInfluence of cement and aggregate type on thaumasite formation in concrete
Nielsen, peter; Sven, Nicolai; Darimont, Anne ULg et al

in Cement & Concrete Composites (2014), 53

In this study the influence of binder type on the formation of thaumasite in mortars made with expanded clay lightweight aggregates (LWA) was examined. For this purpose mortar prisms (20x20x160mm) were ... [more ▼]

In this study the influence of binder type on the formation of thaumasite in mortars made with expanded clay lightweight aggregates (LWA) was examined. For this purpose mortar prisms (20x20x160mm) were made with different binders and expanded clay lightweight aggregate or quartz sand, which after 28 days of curing in water were exposed to a 2.37 % Na2SO4 solution. The length and weight change of the prisms was recorded in triplicate as a function of time of exposure to dry-wet cycles in the sulphate solution or deionised water, at a temperature of 5 ± 1°C. The influence of the binder type on the expansion of the prisms in the 2.37 % Na2SO4 solution with dry and wet cycling can be ordered from strong to weak as follows: (1) CEM I + limestone filler, (2) CEM I, (3) CEM I + fly ash, (4) CEM III. The use of specific cements or cement blends can clearly inhibit the formation of thaumasite (and/or ettringite). The influence of the aggregate type (quartz versus LWA) on the sulphate reaction is more difficult to determine because the porosity of LWA can accommodate the growing sulphate crystals. All the mortar prisms made with quartz aggregate were bent or broken after 21 to 24 weeks exposure to the sulphate solution, while most mortar prisms made with expanded clay aggregate were still intact. The only exception being the mortar prisms containing limestone filler. The latter disintegrated between 24 and 34 weeks of exposure to the sulphate solution. The expansion of the prisms made with CEM I and CEM I + fly ash levelled off between 50 and 100 weeks of exposure to the sulphate solution. The prisms made with CEM III showed minimal expansion (≤ 0.1 %) after 3 years of exposure. The prisms exposed to demineralised water showed no or minimal expansion. The presence and mineralogy of secondary sulphate phases in the mortars was checked by XRD analysis and SEM-EDS analysis of (degraded) mortar prisms. In most cases a solid solution of ettringite-thaumasite was observed. Based on the composition, treatment and expansion of the different mortar prisms, key factors controlling the formation of thaumasite or a solid solution of thaumasite-ettringite are discussed. [less ▲]

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See detailThe retirement of the migrant labor force: pension portability and beyond
Jousten, Alain ULg

in CESifo Economic Studies (2014)

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – ... [more ▼]

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – system sustainability or distributive characteristics. The present paper provides a fresh look at the nexus between these two literatures. It discusses the impact of the European social security coordination mechanisms on individual decision-making and on the functioning of social security systems – with a focus on retirement. The paper argues that such effects are non-negligible and are likely to have major policy consequences. [less ▲]

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See detailRossiter-McLaughlin Observations of 55 Cnc e
Lopez-Morales, Mercedes; Triaud, Amaury H. M. J.; Rodler, Florian et al

in Astrophysical Journal Letters (2014), sous presse

We present Rossiter-McLaughlin observations of the transiting super-Earth 55 Cnc e collected during six transit events between January 2012 and November 2013 with HARPS and HARPS-N. We detect no radial ... [more ▼]

We present Rossiter-McLaughlin observations of the transiting super-Earth 55 Cnc e collected during six transit events between January 2012 and November 2013 with HARPS and HARPS-N. We detect no radial-velocity signal above 35 cm/s (3-sigma) and confine the stellar v sin i to 0.2 +/- 0.5 km/s. The star appears to be a very slow rotator, producing a very low amplitude Rossiter-McLaughlin effect. Given such a low amplitude, the Rossiter-McLaughlin effect of 55 Cnc e is undetected in our data, and any spin-orbit angle of the system remains possible. We also performed Doppler tomography and reach a similar conclusion. Our results offer a glimpse of the capacity of future instrumentation to study low amplitude Rossiter-McLaughlin effects produced by super-Earths. [less ▲]

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See detailHigh TMEM45A expression is correlated to epidermal keratinization
Hayez, Aurélie; Malaisse, Jérémy; Rogiers, Edith et al

in Experimental Dermatology (2014), 23

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See detailPhysicochemical characterization and in vitro assessment of the nutritive value of starch yield from corn dried at different temperatures
Malumba, P.; Odjo, S.; Boudry, Christelle ULg et al

in Stärke = Starch (2014), 66

To assess modifications induced in starch granules during high temperature drying of corn grain and their effect on the nutritive value of corn-starch, physicochemical and structural characteristics of ... [more ▼]

To assess modifications induced in starch granules during high temperature drying of corn grain and their effect on the nutritive value of corn-starch, physicochemical and structural characteristics of starch granules from corn grains dried at different temperatures have been determined. Additionally, their in vitro digestibility and fermentation patterns were investigated, using a two steps in vitro model of the pig digestive tract. High drying temperatures induced a partial gelatinization of starch granules and produced a very favorable substrate for porcine pancreatic amylase and led to an altered physical structure which affected the rate and extent of starch granules digestion by gastric and pancreatic enzymes. Starch micrographs showed that granules extracted from corn dried at 130°C were less angular, bigger, and had smoother surface than granules extracted from corn dried at lower temperature. High-temperature drying increased the digestibility of wet-milled starch granules, while the residues of starch from corn dried at lower temperature produced higher volume of gas during their in vitro fermentation, despite their more pronounced crystalline characteristic. The residues from pepsin–pancreatic digestion of overall samples analyzed showed highly degraded and pitted granules or fragmented external shells, starch from corn dried at 130°C being the most degraded. Aforementioned changes of nutritional attributes of starch granules are discussed according to the restructuration occurring within both their amorphous and crystalline phase, as well as to the changes of the granules size and purity. [less ▲]

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See detailBrain natriuretic peptide release in patients with aortic stenosis: Resting and exercise echocardiographic determinants.
Henri, Christine; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014), 172(3), 611-3

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See detailInitial uncertainty in Pavlovian reward prediction persistently elevates incentive salience and extends sign-tracking to normally unattractive cues
Robinson, Mike J.F.; Anselme, Patrick ULg; Fischer, Adam M. et al

in Behavioural Brain Research (2014), 266(1), 119-130

Uncertainty is a component of many gambling games and may play a role in incentive motivation and cue attraction. Uncertainty can increase the attractiveness for predictors of reward in the Pavlovian ... [more ▼]

Uncertainty is a component of many gambling games and may play a role in incentive motivation and cue attraction. Uncertainty can increase the attractiveness for predictors of reward in the Pavlovian procedure of autoshaping, visible as enhanced sign-tracking (or approach and nibbles) by rats of a metal lever whose sudden appearance acts as a conditioned stimulus (CS+) to predict sucrose pellets as an unconditioned stimulus (UCS). Here we examined how reward uncertainty might enhance incentive salience as sign-tracking both in intensity and by broadening the range of attractive CS+s. We also examined whether initially-induced uncertainty enhancements of CS+ attraction can endure beyond uncertainty itself, and persist even when Pavlovian prediction becomes 100% certain. Our results show that uncertainty can broaden incentive salience attribution to make CS cues attractive that would otherwise not be (either because they are too distal from reward or too risky to normally attract sign-tracking). In addition, uncertainty enhancement of CS+ incentive salience, once induced by initial exposure, persisted even when Pavlovian CS-UCS correlations later rose toward 100% certainty in prediction. Persistence suggests an enduring incentive motivation enhancement potentially relevant to gambling, which in some ways resembles incentive-sensitization. Higher motivation to uncertain CS+s leads to more potent attraction to these cues when they predict the delivery of uncertain rewards. In humans, those cues might possibly include the sights and sounds associated with gambling, which contribute a major component of the play immersion experienced by problematic gamblers. [less ▲]

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See detailComment comprendre l’influence au sein de groupes d’adolescents ? Le conflit socio-cognitif en appui de la théorie de l’apprentissage social
Mathys, Cécile ULg; Vitaro, Frank; Born, Michel ULg

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2014), 46(2), 289-230

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See detailShort communication: Alteration of priors for random effects in Gaussian linear mixed models
Vandenplas, Jérémie ULg; Christensen, Ole F.; Gengler, Nicolas ULg

in Journal of Dairy Science (2014), 97(9), 5880-5884

Linear mixed models, for which the prior multivariate normal distributions of random effects are assumed to have a mean equal to 0, are commonly used in animal breeding. However, some statistical analyses ... [more ▼]

Linear mixed models, for which the prior multivariate normal distributions of random effects are assumed to have a mean equal to 0, are commonly used in animal breeding. However, some statistical analyses (e.g., the consideration of a population under selection into a genomic scheme breeding, multiple-trait predictions of lactation yields, Bayesian approaches integrating external information into genetic evaluations) need to alter both the mean and (co)variance of the prior distributions and, to our knowledge, most software packages available in the animal breeding community do not permit such alterations. Therefore, the aim of this study was to propose a method to alter both the mean and (co)variance of the prior multivariate normal distributions of random effects of linear mixed models while using currently available software packages. The proposed method was tested on simulated examples with three different software packages available in animal breeding. The examples showed the possibility of the proposed method to alter both the mean and (co)variance of the prior distributions with currently available software packages through the use of an extended data file and a user supplied (co)variance matrix. [less ▲]

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See detailIncrease in dimethylsulfide (DMS) emissions due to eutrophication of coastal waters offsets their reduction due to ocean acidification
Gypens, N; Borges, Alberto ULg

in Frontiers in Marine Science - Marine Ecosystem Ecology (2014), 1(4),

Available information from manipulative experiments suggested that the emission of dimethylsulfide (DMS) would decrease in response to the accumulation of anthropogenic CO2 in the ocean (ocean ... [more ▼]

Available information from manipulative experiments suggested that the emission of dimethylsulfide (DMS) would decrease in response to the accumulation of anthropogenic CO2 in the ocean (ocean acidification). However, in coastal environments, the carbonate chemistry of surface waters was also strongly modified by eutrophication and related changes in biological activity (increased primary production and change in phytoplankton dominance) during the last 50 years. Here, we tested the hypothesis that DMS emissions in marine coastal environments also strongly responded to eutrophication in addition to ocean acidification at decadal timescales. We used the R-MIRO-BIOGAS model in the eutrophied Southern Bight of the North Sea characterized by intense blooms of Phaeocystis that are high producers of dimethylsulfoniopropionate (DMSP), the precursor of DMS. We showed that, for the period from 1951 to 2007, eutrophication actually led to an increase of DMS emissions much stronger than the response of DMS emissions to ocean acidification. [less ▲]

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See detailRepresentations of sensory experiences in the early phases of architectural design: there is more than meets the eye
Elsen, Catherine ULg; Heylighen, Ann

in Journal of Design Research (2014), 12(4),

In response to questions about designers’ visual way of knowing and working, this article explores how sensory experience is conveyed during the early phases of architectural design. By processing 985 ... [more ▼]

In response to questions about designers’ visual way of knowing and working, this article explores how sensory experience is conveyed during the early phases of architectural design. By processing 985 graphic components issued from a three-month ethnographic observation inside an architecture firm, and proposing an original methodology for their analysis, we identify and analyse graphic expressions of sensory-related design intentions. Multi-sensory dimensions of experiencing an architectural artefact, and the way architects deal with users experiencing space differently, are topics also considered in this article. The resulting observations remind us not to mistake apparent lack of graphical clues with lack of sensibility when it comes to addressing sensory experience during architectural design. [less ▲]

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See detailChemical composition, cytotoxicity and in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin.
Kpoviessi, Salome; Bero, Joanne; Agbani, Pierre et al

in Journal of ethnopharmacology (2014), 151

ETHNOPHARMACOLOGICAL RELEVANCE: Cymbopogon species are largely used in folk medicine for the treatment of many diseases some of which related to parasitical diseases as fevers and headaches. As part of ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Cymbopogon species are largely used in folk medicine for the treatment of many diseases some of which related to parasitical diseases as fevers and headaches. As part of our research on antiparasitic essential oils from Beninese plants, we decided to evaluate the in vitro antiplasmodial and antitrypanosomal activities of essential oils of four Cymbopogon species used in traditional medicine as well as their cytotoxicity. MATERIALS AND METHODS: The essential oils of four Cymbopogon species Cymbopogon citratus (I), Cymbopogon giganteus (II), Cymbopogon nardus (III) and Cymbopogon schoenantus (IV) from Benin obtained by hydrodistillation were analysed by GC/MS and GC/FID and were tested in vitro against Trypanosoma brucei brucei and Plasmodium falciparum respectively for antitrypanosomal and antiplasmodial activities. Cytotoxicity was evaluated in vitro against Chinese Hamster Ovary (CHO) cells and the human non cancer fibroblast cell line (WI38) through MTT assay to evaluate the selectivity. RESULTS: All tested oils showed a strong antitrypanosomal activity with a good selectivity. Sample II was the most active against Trypanosoma brucei brucei and could be considered as a good candidate. It was less active against Plasmodium falciparum. Samples II, III and IV had low or no cytotoxicity, but the essential oil of Cymbopogon citraus (I), was toxic against CHO cells and moderately toxic against WI38 cells and needs further toxicological studies. Sample I (29 compounds) was characterised by the presence as main constituents of geranial, neral, beta-pinene and cis-geraniol; sample II (53 compounds) by the presence of trans-p-mentha-1(7),8-dien-2-ol, trans-carveol, trans-p-mentha-2,8-dienol, cis-p-mentha-2,8-dienol, cis-p-mentha-1(7),8-dien-2-ol, limonene, cis-carveol and cis-carvone; sample III (28 compounds) by beta-citronellal, nerol, beta-citronellol, elemol and limonene and sample IV (41 compounds) by piperitone, (+)-2-carene, limonene, elemol and beta-eudesmol. CONCLUSIONS: Our study shows that essential oils of Cymbopogon genus can be a good source of antitrypanosomal agents. This is the first report on the activity of these essential oils against Trypanosoma brucei brucei, Plasmodium falciparum and analysis of their cytotoxicity. [less ▲]

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See detailA Statistically adaptive sampling policy to the Hotelling's T2 Control Chart: Markov Chain Approach
Seif, A.; Faraz, Alireza ULg; Heuchenne, Cédric ULg et al

in Communications in Statistics : Theory & Methods (2014)

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See detailDisproportionate contribution of riparian inputs to organic carbon pools in freshwater systems
Marwick, T.R.; Borges, Alberto ULg; Van Acker, K. et al

in Ecosystems (2014), 17

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See detailComparative evaluation of existing and new methods for correcting ocular artifacts in electroencephalographic recordings
Kirkove, Murielle ULg; François, Clémentine ULg; Verly, Jacques ULg

in Signal Processing (2014), 98(C), 102-120

EEG signals are often contaminated by ocular artifacts (OAs), in particular when they are recorded for a subject that is, in principle, awake, such as in a study of drowsiness. It is generally desirable ... [more ▼]

EEG signals are often contaminated by ocular artifacts (OAs), in particular when they are recorded for a subject that is, in principle, awake, such as in a study of drowsiness. It is generally desirable to detect and/or correct these OAs before interpreting the EEG signals. We have identified 11 existing methods for dealing with OAs. Their study allowed us to create 16 new methods. We performed a comparative performance evaluation of the resulting 27 distinct methods using a common set of data and a common set of metrics. The data was recorded during a driving task of about two hours in a driving simulator. This led to a ranking of all methods, with five emerging clear winners, comprising two existing methods and three new ones. [less ▲]

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See detailFacies characterization of organic-rich mudstones from the Chokier Formation (lower Namurian), south Belgium
Nyhuis, Christian; Rippen, Daniel; Denayer, Julien ULg

in Geologica Belgica (2014), 17(3-4), 311-322

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See detailA phase IIa, nonrandomized study of radium-223 dichloride in advanced breast cancer patients with bone-dominant disease.
Coleman, Robert; Aksnes, Anne-Kirsti; Naume, Bjorn et al

in Breast cancer research and treatment (2014)

Radium-223 dichloride (radium-223) mimics calcium and emits high-energy, short-range alpha-particles resulting in an antitumor effect on bone metastases. This open-label, phase IIa nonrandomized study ... [more ▼]

Radium-223 dichloride (radium-223) mimics calcium and emits high-energy, short-range alpha-particles resulting in an antitumor effect on bone metastases. This open-label, phase IIa nonrandomized study investigated safety and short-term efficacy of radium-223 in breast cancer patients with bone-dominant disease. Twenty-three advanced breast cancer patients with progressive bone-dominant disease, and no longer candidates for further endocrine therapy, were to receive radium-223 (50 kBq/kg IV) every 4 weeks for 4 cycles. The coprimary end points were change in urinary N-telopeptide of type 1 (uNTX-1) and serum bone alkaline phosphatase (bALP) after 16 weeks of treatment. Exploratory end points included sequential 18F-fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) to assess metabolic changes in osteoblastic bone metastases. Safety data were collected for all patients. Radium-223 significantly reduced uNTX-1 and bALP from baseline to end of treatment. Median uNTX-1 change was -10.1 nmol bone collagen equivalents/mmol creatinine (-32.8 %; P = 0.0124); median bALP change was -16.7 ng/mL (-42.0 %; P = 0.0045). Twenty of twenty-three patients had FDG PET/CT identifying 155 hypermetabolic osteoblastic bone lesions at baseline: 50 lesions showed metabolic decrease (>/=25 % reduction of maximum standardized uptake value from baseline) after 2 radium-223 injections [32.3 % metabolic response rate (mRR) at week 9], persisting after the treatment period (41.5 % mRR at week 17). Radium-223 was safe and well tolerated. Radium-223 targets areas of increased bone metabolism and shows biological activity in advanced breast cancer patients with bone-dominant disease. [less ▲]

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See detailConcomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects
Vignisse, Julie ULg; Steinbusch, Harry W.M.; Grigoriev, Vladimir et al

in European Neuropsychopharmacology (2014), 24

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA ... [more ▼]

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA receptors or the potentiation of AMPA receptors is well documented to result in memory enhancement. Here, we compared the efficacy of the low-affinity NMDA receptor blocker memantine or the positive modulator of AMPA receptor QXX (in C57BL/6J at 1 or 5 mg/kg, ip) with new derivatives of isothiourea (0.5-1 mg/kg, ip) that have bifunctional efficacy. Low-affinity NMDA blockade by these derivatives was achieved by introducing greater flexibility into the molecule, and AMPA receptor stimulation was produced by a sulfamide-containing derivative of isothiourea. Contextual learning was examined in a step-down avoidance task and extinction of contextual memory was studied in a fear-conditioning paradigm. Memantine enhanced contextual learning while QXX facilitated memory extinction; both drugs were effective at 5 mg/kg. The new derivative IPAC-5 elevated memory scores in both tasks at the dose 0.5 mg/Kg and exhibited the lowest IC50 values of NMDA receptor blockade and highest potency of AMPA receptor stimulation. Thus, among the new drugs tested, IPAC-5 plicated the properties of memantine and QXX in one administration with increased potency. Our data suggest that a concomitant manipulation of NMDA- and AMPA-receptors results in pro-cognitive effects and supports the concept bifunctional drug therapy as a promising strategy to replace monofunctional therapies with greater efficacy and improved compliance. [less ▲]

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See detailStimulant and motivational effects of alcohol: Lessons from rodent and primate models
Brabant, Christian ULg; Guarnieri, Douglas J.; Quertemont, Etienne ULg

in Pharmacology, Biochemistry & Behavior (2014), 122

In several animal species including humans, the acute administration of low doses of alcohol increasesmotor activity. Different theories have postulated that alcohol-induced hyperactivity is causally ... [more ▼]

In several animal species including humans, the acute administration of low doses of alcohol increasesmotor activity. Different theories have postulated that alcohol-induced hyperactivity is causally related to alcoholism.Moreover, a common biological mechanism in the mesolimbic dopamine system has been proposed to mediate the stimulant and motivational effects of alcohol. Numerous studies have examined whether alcohol-induced hyperactivity is related to alcoholism using a great variety of animal models and several animal species. However, there is no review that has summarized this extensive literature. In this article, we present the various experimental models that have been used to study the relationship between the stimulant and motivational effects of alcohol in rodents and primates. Furthermore, we discuss whether the theories hypothesizing a causal link between alcohol-induced hyperactivity and alcoholism are supported by published results. The reviewed findings indicate that animal species that are stimulated by alcohol also exhibit alcohol preference. Additionally, the role of dopamine in alcohol-induced hyperactivity is well established since blocking dopaminergic activity suppresses the stimulant effects of alcohol. However, dopamine transmission plays a much more complex function in the motivational properties of alcohol and the neuronal mechanisms involved in alcohol stimulation and reward are distinct. Overall, the current review provides mixed support for theories suggesting that the stimulant effects of alcohol are related to alcoholism and highlights the importance of animal models as a way to gain insight into alcoholism. [less ▲]

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See detailAnalysis of collagen preservation in bones recovered in archaeological contexts using NIR Hyperspectral Imaging
Vincke, Damien; Miller, Rebecca ULg; Stassart, Edith ULg et al

in Talanta (2014), 125

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen ... [more ▼]

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen preservation in bones recovered from archaeological contexts. This preliminary study has allowed the evaluation of the potential of the method using bone samples from the Early Upper Palaeolithic, Mesolithic and Neolithic periods at the site of Trou Al'Wesse in Belgium. NIR-HCI, combined with chemometric tools, has identified specific spectral bands characteristic of collagen. A chemometric model has been built using Partial Least Squares Discriminant Analysis (PLS-DA) to identify bones with and without collagen. This enables the evaluation of the degree of collagen preservation and homogeneity in bones within and between different strata, which has direct implications for archaeological applications (e.g., taphonomic analyses, assemblage integrity) and sample selection for sub- sequent analyses requiring collagen. Two archaeological applications are presented: comparison between sub-layers in an Early Upper Palaeolithic unit, and evaluation of the range of variability in collagen preservation within a single Holocene stratum. [less ▲]

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See detailRecommendations for transoesophageal echocardiography: EACVI update 2014.
Flachskampf, Frank A.; Wouters, Patrick F.; Edvardsen, Thor et al

in European heart journal cardiovascular Imaging (2014), 15(4), 353-65

With this document, we update the recommendations for transoesophageal echocardiography (TOE) of the European Association of Cardiovascular Imaging. The document focusses on the areas of interventional ... [more ▼]

With this document, we update the recommendations for transoesophageal echocardiography (TOE) of the European Association of Cardiovascular Imaging. The document focusses on the areas of interventional TOE, in particular transcatheter aortic, mitral, and left atrial appendage interventions, as well as on the role of TOE in infective endocarditis, adult congenital heart disease, and aortic disease. [less ▲]

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See detailLes vergetures, leurs couleurs et leur mécanobiologie.
FRANCHIMONT, Claudine ULg; Peters, S.; Hermanns, J.F. et al

in Revue Médicale de Liège (2014), 69

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See detailSpread of hatch and delayed feed access affect post hatch performance of female broiler chicks up to day 5.
Wang, Y.; Li, Yue; Willems, E. et al

in Animal (2014)

It is not rare that newly hatched chicks remain without feed for about 24 to 48 h before they are placed on farms due to a series of logistic operations. Furthermore, the spread in hatching time can also ... [more ▼]

It is not rare that newly hatched chicks remain without feed for about 24 to 48 h before they are placed on farms due to a series of logistic operations. Furthermore, the spread in hatching time can also mount up to 30 to 48 h for late v. early hatchers. In other words, the practice is a complex combination of spread of hatch and delayed feed access. The present study was aimed to investigate the combined effects of hatching time with a delay in feed access of 48 h, starting from their hatch-time (biological age). When chicks had access to feed immediately after hatch, late hatchers had a higher feed intake and relative growth rate up to day 5 compared with their early hatched counterparts. Feed deprivation during the first 48 h resulted in retarded early growth rate, which was further aggravated by an impaired feed intake after refeeding. In addition, the differential effects of hatching time on relative growth rate and feed intake observed in immediately fed chicks were eliminated by the 48 h feed delay. The yolk utilization after hatch was faster for the late hatchers up to biological day 2 regardless of the feeding treatments. Hatching muscle glycogen content was higher in the late hatchers compared with that of their early counterparts at hatch and at biological day 2 independent of feeding treatment. Moreover, the liver glycogen content of the late hatchers was also higher at hatch. For the immediately fed chicks, the proportional breast muscle weight of the late hatchers was higher at biological day 2 and 5. For the starved chicks, on the other hand, this effect was only observed after they had access to feed (biological day 5). The different plasma T3 levels at hatch may have contributed to the different post hatch performance. It is concluded that the spread of hatch influenced post hatch performance, especially appetite and growth at least until day 5. Moreover, the delay in feed access interacted with the hatching time and caused adverse effects on the post hatch performance. [less ▲]

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See detailSHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Elong Edimo, W; Schurmans, Stéphane ULg; Roger, PP et al

in Advances in Biological Regulation (2014), 54

Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of PI(3,4,5)P3, PI(4,5)P2 and PI(3,5)P2. The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to ... [more ▼]

Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of PI(3,4,5)P3, PI(4,5)P2 and PI(3,5)P2. The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2. Data obtained in zebrafish and in mice have shown that SHIP2 is critical in development and growth. Exome sequencing identifies mutations in the coding region of SHIP2 as a cause of opsismodysplasia, a severe but rare chondrodysplasia in human. SHIP2 has been reported to have both protumorigenic and tumor suppressor function in human cancer very much depending on the cell model. This could be linked to the relative importance of PI(3,4)P2 (a product of SHIP2 phosphatase activity) which is also controlled by the PI 4-phosphatase and tumor suppressor INPP4B. In the glioblastoma cell line 1321 N1, that do not express PTEN, lowering SHIP2 expression has an impact on the levels of PI(3,4,5)P3, cell morphology and cell proliferation. It positively stimulates cell proliferation by decreasing the expression of key regulatory proteins of the cell cycle such as p27. Together the data point out to a role of SHIP2 in development in normal cells and at least in cell proliferation in some cancer derived cells. [less ▲]

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See detailOutcomes of adults with active or progressive hematological malignancies at time of allogeneic stem cell transplantation : a survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Chevallier, P.; Labopin, M.; Milpied, N. et al

in Bone Marrow Transplantation (2014), 49

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective ... [more ▼]

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective study aimed to analyze the outcome of adult patients who received allo-SCT in a chemo-refractory/relapsed status. The series included 840 patients with active or progressive disease at the time of transplant. Median age was 50 years. With a median follow-up of 40 months, 3-year OS, disease-free survival (DFS), and non-relapse mortality rates were 29±2, 23±2, and 30±2%, respectively. At the last follow-up, 252 patients (30%) were still alive (of whom 201 were in CR (24%). In a Cox multivariate analysis, the use of a reduced-intensity conditioning (RIC) before allo-SCT and use of an HLA-identical sibling donor remained independently associated with a better OS (hazard ratio (HR)¼0.82; 95% confidence interval (CI), 0.69–0.98, P¼0.03; and HR¼0.79; 95% CI, 0.66–0.93, P¼0.006, respectively). Also, a diagnosis of myelodysplastic syndrome/myeloproliferative disorder, Hodgkin lymphoma and non-Hodgkin lymphoma compared with acute leukemia had a favorable impact on OS (HR¼0.55; 95% CI, 0.45–0.68, Po0.0001; HR¼0.49; 95% CI, 0.31–0.75, P¼0.001; and HR¼0.47; 95% CI, 0.35–0.63, Po0.0001, respectively). In conclusion, this study suggests that allo-SCT may be of benefit in some subgroups of patients with active or progressive hematological malignancies at the time of allo-SCT. [less ▲]

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See detailCervical cancer and HPV: Awareness and vaccine acceptability among parents in Morocco.
Mouallif, Mustapha; Bowyer, Harriet L.; Festali, Soukaina et al

in Vaccine (2014), 32(3), 409-16

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since ... [more ▼]

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since 2008 but there are no available data on their acceptability. This study aimed to assess awareness of HPV and the vaccine, and to identify factors associated with acceptability of the vaccine among parents in Morocco. We carried out a questionnaire-based survey using face-to-face interviews in a sample of 852 parents (670 mothers and 182 fathers) with at least one unmarried daughter </=26 years. We collected data within public and private health centres and clinics in four regions in Morocco between July and August 2012. The main outcome measure was parental acceptability of the HPV vaccine for their daughter(s). Responses revealed very low awareness of HPV infection (4.7%) and the HPV vaccine (14.3%). None of the participants had vaccinated their daughter(s) against HPV and vaccine acceptability was low among mothers (32%) and fathers (45%). Higher education and income, previous awareness of the HPV vaccine and endorsement of the belief that a recommendation from the Ministry of Health or a doctor to have the vaccine would be encouraging, were associated with mothers' HPV vaccine acceptability. Non-acceptability among mothers was associated with having more than two daughters, believing the vaccine was expensive, lack of information and believing that whatever happens to an individual's health is God's will. The only factor associated with the fathers' acceptability of the vaccine was the cost of the vaccine. Increasing HPV and HPV vaccine awareness through educational campaigns, along with active recommendation by physicians and a publically funded vaccination programme could increase parental acceptability of the HPV vaccine in Morocco. [less ▲]

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See detailPsychrotrophic lactic acid bacteria associated with production batch recalls and sporadic cases of early spoilage in Belgium between 2010 and 2014
Pothakos, Vasileios; Taminiau, Bernard ULg; Huys, Geert et al

in International Journal of Food Microbiology (2014), 191

Between 2010 and 2014 several spoilage cases in Belgium occurring in retail foodstuffs prior to the end of shelf-life have been reported to our laboratory. Overall, seven cases involved strictly ... [more ▼]

Between 2010 and 2014 several spoilage cases in Belgium occurring in retail foodstuffs prior to the end of shelf-life have been reported to our laboratory. Overall, seven cases involved strictly psychrotrophic lactic acid bacteria (LAB) contamination in packaged and chilled-stored food products. The products derived either fromrecalls of entire production batches or as specimens of sporadic spoilage manifestations. Some of these samples were returned to the manufacturing companies by consumers who observed the alterations after purchasing the products. The products covered a wide range of foodstuffs (i.e. meat, dairy, vegetable, egg products and composite food) and denoted different spoilage defects. However, the microbiota determined by means of 16S rRNA gene high throughput sequencing analysis underpin few LAB genera (i.e. Leuconostoc, Lactobacillus, Weissella and Lactococcus), which are frequently encountered nowadays as specific spoilage organisms (SSO) albeit overlooked by mesophilic enumeration methods due to their strictly psychrotrophic character. The present study confirms the spreading of psychrotrophic LAB in Belgian food processing environments leading to unexpected spoilage, corroborating their spoilage dynamics and prevalence in all kinds of packaged and refrigerated foodstuffs in Northern Europe. [less ▲]

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