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See detailDynamic seasonal nitrogen cycling in response to anthropogenic N loading in a tropical catchment, Athi–Galana–Sabaki River, Kenya
Marwick, T. R.; Tamooh, F.; Ogwoka, B. et al

in Biogeosciences (2014), 11(2), 443--460

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See detailInflammation as a link between obesity, metabolic syndrome and type 2 diabetes
ESSER, Nathalie ULg; Legrand, Sylvie ULg; Piette, Jacques ULg et al

in Diabetes Research & Clinical Practice (2014)

It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic ... [more ▼]

It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose tissue, liver, muscle and pancreas are themselves sites of inflammation in presence of obesity. An infiltration of macrophages and other immune cells is observed in these tissues associated with a cell population shift from an anti-inflammatory to a pro-inflammatory profile. These cells are crucial for the production of pro-inflammatory cytokines, which act in an autocrine and paracrine manner to interfere with insulin signaling in peripheral tissues or induce β-cell dysfunction and subsequent insulin deficiency. Particularly, the pro-inflammatory interleukin-1β is implicated in the pathogenesis of type 2 diabetes through the activation of the NLRP3 inflammasome. The objectives of this review are to expose recent data supporting the role of the immune system in the pathogenesis of insulin resistance and type 2 diabetes and to examine various mechanisms underlying this relationship. If type 2 diabetes is an inflammatory disease, anti-inflammarory therapies could have a place in prevention and treatment of type 2 diabetes. [less ▲]

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See detailThe evaluation of unmanned aerial systems-based photogrammetry and terrestrial laser scanning to generate DEMs of agricultural watersheds
Ouedraogo, Mohamar ULg; Degré, Aurore ULg; Debouche, Charles ULg et al

in Geomorphology (2014)

Agricultural watersheds tend to be places of intensive farming activities that permanently modify their microtopography. The surface characteristics of the soil vary depending on the crops that are ... [more ▼]

Agricultural watersheds tend to be places of intensive farming activities that permanently modify their microtopography. The surface characteristics of the soil vary depending on the crops that are cultivated in these areas. Agricultural soil microtopography plays an important role in the quantification of runoff and sediment transport because the presence of crops, crop residues, furrows and ridges may impact the direction of water flow. To better assess such phenomena, 3-D reconstructions of high-resolution agricultural watershed topography is essential. Fine-resolution topographic data collection technologies can be used to discern highly detailed elevation variability in these areas. Knowledge of the strengths and weaknesses of existing technologies used for data collection on agricultural watersheds may be helpful in choosing an appropriate technology. This study assesses the suitability of terrestrial laser scanning (TLS) and unmanned aerial system (UAS) photogrammetry for collecting the fine-resolution topographic data required to generate accurate, high-resolution digital elevation models (DEMs) in a small watershed area (12 ha). Because of farming activity, 14 TLS scans (≈ 25 points m− 2) were collected without using high-definition surveying (HDS) targets, which are generally used to mesh adjacent scans. To evaluate the accuracy of the DEMs created from the TLS scan data, 1,098 ground control points (GCPs) were surveyed using a real time kinematic global positioning system (RTK-GPS). Linear regressions were then applied to each DEM to remove vertical errors from the TLS point elevations, errors caused by the non-perpendicularity of the scanner’s vertical axis to the local horizontal plane, and errors correlated with the distance to the scanner’s position. The scans were then meshed to generate a DEMTLS with a 1 × 1 m spatial resolution. The Agisoft PhotoScan and MicMac software packages were used to process the aerial photographs and generate a DEMPSC (Agisoft PhotoScan) and DEMMCM (MicMac), respectively, with spatial resolutions of 1 × 1 m. Comparing the DEMs with the 1,098 GCPs showed that the DEMTLS was the most accurate data product, with a root mean square error (RMSE) of 4.5 cm, followed by the DEMMCM and the DEMPSC, which had RMSE values of 9.0 and 13.9 cm, respectively. The DEMPSC had absolute errors along the border of the study area that ranged from 15.0 to 52.0 cm, indicating the presence of systematic errors. Although the derived DEMMCM was accurate, an error analysis along a transect showed that the errors in the DEMMCM data tended to increase in areas of lower elevation. Compared with TLS, UAS is a promising tool for data collection because of its flexibility and low operational cost. However, improvements are needed in the photogrammetric processing of the aerial photographs to remove non-linear distortions. [less ▲]

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See detailLe Fonds Hubert Nyssen à l'Université de Liège
Durand, Pascal ULg; Habrand, Tanguy ULg

in Histoires littéraires (2014), 58

Biographie croisée de l'écrivain et de l'éditeur Hubert Nyssen et présentation détaillée du Fonds d'archives déposé par lui au Centre d'Etude du Livre Contemporain de l'Université de Liège.

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See detailControllable morphology of flux avalanches in microstructured superconductors
Motta, M.; Colauto, F.; Vestgarden, J.I. et al

in Physical Review. B : Condensed Matter (2014)

The morphology of abrupt bursts of magnetic flux into superconducting films with engineered periodic pinning centers (antidots) has been investigated. Guided flux avalanches of thermomagnetic origin ... [more ▼]

The morphology of abrupt bursts of magnetic flux into superconducting films with engineered periodic pinning centers (antidots) has been investigated. Guided flux avalanches of thermomagnetic origin develop a tree-like structure, with the main trunk perpendicular to the borders of the sample, while secondary branches follow well-defi ned directions determined by the geometrical details of the underlying periodic pinning landscape. Strikingly, we demonstrate that in a superconductor with relatively weak random pinning, the morphology of such flux avalanches can be fully controlled by proper combinations of lattice symmetry and antidot geometry. Moreover, the resulting flux patterns can be reproduced, to the fi nest details, by simulations based on a phenomenological thermomagnetic model. In turn, this model can be used to predict such complex structures and to estimate physical variables of more di fficult experimental access, such as the local values of temperature and electric fi eld. [less ▲]

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See detailA one phase thermomechanical model for the numerical simulation of semi-solid material behavior. Application to thixoforming
Koeune, Roxane; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2014), 58

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called ... [more ▼]

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called thixotropy that can be displayed by some metallic alloys heated up to their semi-solid state. It is a particular evolutionary behavior which is characterized by a solidlike behavior at rest and a liquid flow during shearing, thus by a decrease of the viscosity and of the resistance to deformation while sheared. An original one-phase thermo-elasto-viscoplastic constitutive model has been developed. The basic idea is to extend the classical isotropic hardening and viscosity models beyond the solid state by considering two more non-dimensional internal scalar parameters. The semi-solid state is treated as a particular case, and one of the main features of the proposed constitutive model is that it remains valid over a wide range of temperatures, starting from room temperature to above the liquidus in a continuous manner, thus allowing a continuous transition between classical solid and fluid behavior. Another feature is that, after the forming step, it is possible to simulate the cooling down of the component back to room temperature using the elastic–viscoplastic model. So it is possible to estimate residual stresses, something that is definitely impossible while using a fluid-like model or a rigid viscoplastic approach. The presented model is illustrated and validated by means of representative numerical applications, as two different extrusion tests are carried out and the computed predictions are compared to experimental results. [less ▲]

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See detailControl of citrus blue mold by the antagonist yeast Pichia guilliermondii Z1: compatibility with commercial fruit waxes and putative mechanisms of action.
Lahlali, Rachid; Hamadi, Younes; Drider, R. et al

in Food Control (2014), 45

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an ... [more ▼]

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an alternative for synthetic fungicides, would be compatible with other postharvest practices used commercially. In particular, commercial fruit waxes can reduce their survival and effectiveness. The commercial fruit waxes tested, in combination at 20% with strain Z1, included microcrystalline, ester gum, candelilla, beeswax, montan, paraffin, rice bran, rosin maleic, carnauba, shellac, and one mixture shellac plus carnauba. Beeswax, paraffin, rosin maleic, carnauba, and shellac increased significantly strain Z1 survival in Petri dish assays. Candelilla, beeswax, rice bran, rosin maleic, carnauba, shellac, and shellacecarnauba mixture did not significantly reduce the strain Z1 yield on orange fruit surfaces compared to other waxes. With the exception of rosin maleic wax, none of the commercial fruit waxes or mixture increased significantly the ability of the formulated product of strain Z1 to control the postharvest pathogen Penicillium italicum on wounded orange fruit. When the formulated product of strain Z1 was used in combination with beeswax, strain Z1 retained the same efficacy. In contrast, microcrystalline, ester gum, candelilla, montan, paraffin, rice bran, carnauba, shellac, and shellac-carnauba mixture significantly reduced the effectiveness of the formulated product of strain Z1. No antibiosis was detected for strain Z1 against P. italicum. Strain Z1 inhibited the spore germination for the low juice concentration (up to 5%) when compared to the control. However, the addition of fresh juice after antagonist removal allowed the restoration of the germination of P. italicum spores; suggesting the possibility of competition for nutrients in the biocontrol activity of strain Z1. The study demonstrates the potential commercial application of strain Z1 with beeswax and rosin maleic wax for postharvest control of citrus blue mold. As biocontrol relies on competition for nutrients, an enriched formulation with nutrients is needed for reliable antifungal activity of this yeast strain [less ▲]

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See detailEclipsing Am binary systems in the SuperWASP survey
Smalley, B.; Southworth, J.; Pintado, O. I. et al

in Astronomy and Astrophysics (2014), 564

The results of a search for eclipsing Am star binaries using photometry from the SuperWASP survey are presented. The light curves of 1742 Am stars fainter than V = 8.0 were analysed for the presence of ... [more ▼]

The results of a search for eclipsing Am star binaries using photometry from the SuperWASP survey are presented. The light curves of 1742 Am stars fainter than V = 8.0 were analysed for the presence of eclipses. A total of 70 stars were found to exhibit eclipses, with 66 having sufficient observations to enable orbital periods to be determined and 28 of which are newly identified eclipsing systems. Also presented are spectroscopic orbits for 5 of the systems. The number of systems and the period distribution is found to be consistent with that identified in previous radial velocity surveys of "classical" Am stars. [less ▲]

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See detailCurrent challenges in the treatment of osteoporosis: an opportunity for bazedoxifene.
Reginster, Jean-Yves ULg; Ferrari, Serge; Hadji, Peyman

in Current medical research and opinion (2014), 30(6), 1165-1176

Abstract Background: Osteoporosis affects millions of postmenopausal women worldwide. Osteoporosis-related fractures can lead to chronic pain, disability, systemic complications, and increased risk of ... [more ▼]

Abstract Background: Osteoporosis affects millions of postmenopausal women worldwide. Osteoporosis-related fractures can lead to chronic pain, disability, systemic complications, and increased risk of recurrent fractures, resulting in increased healthcare costs and mortality. Because currently available therapies have unique benefit/risk profiles, challenges remain in selecting the most appropriate treatment for each osteoporotic woman. Research and Results: Bazedoxifene (BZA), a new selective estrogen receptor modulator, is being developed for postmenopausal osteoporosis. In a 3-year, global, phase 3 study, BZA significantly reduced the risk of new vertebral fractures and nonvertebral fractures in women with higher baseline fracture risk compared with placebo. In 2 extensions of this study, the efficacy of BZA in reducing vertebral fracture risk was sustained over 7 years. BZA improved lumbar spine and total hip bone mineral density compared with placebo at 3 and 5 years, and demonstrated a favorable safety/tolerability profile, with no endometrial or breast stimulation. BZA was cost-effective compared with raloxifene in a 3-year, head-to-head comparative trial. Indirect comparisons further suggest that BZA may be as effective as bisphosphonates in reducing risk of nonvertebral fractures in women at high risk of fracture. BZA demonstrated efficacy and safety for treating postmenopausal osteoporosis over 7 years, particularly in women at a higher fracture risk. Conclusion: Because of its specific pharmacologic profile, BZA may be appropriate for postmenopausal women seeking a tolerable, safe, effective, and cost-effective long-term osteoporosis treatment. [less ▲]

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See detailCardiovascular imaging.
Lancellotti, Patrizio ULg; Habib, Gilbert; Negila, Danilo et al

in European heart journal (2014), 35(18), 1161-2

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See detailPolitical Participation of Latin American Migrants in Andalusia: Opportunities and Constraints
Bermudez Torres, Anastasia ULg; Escriva, Angeles; Moraes, Natalia

in Migraciones Internacionales (2014), 7(3), 73-98

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The ... [more ▼]

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The project uses a broad concept of what political participation constitutes, including both civic practices and activities associated with conventional politics, and adopts a transnational perspective. It is based on 45 semi-structured interviews with politically active migrants and members of political parties and other institutions. The article highlights some of the main findings of the research, including the importance of taking into account migrants’ previous political experiences, as well as the role played by migrant associations in order to better understand their political practices. [less ▲]

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See detailThe impact of expertise on the capture of sketched intentions: perspectives for remote cooperative design
Sutera, Jennifer; Yang, Maria C.; Elsen, Catherine ULg

in Lecture Notes in Computer Science (2014), 8683

The paper describes the way expertise and field-knowledge can impact the transfer of graphical intentions during architectural cooperative design. The analysis of 28 controlled experiments reveals what ... [more ▼]

The paper describes the way expertise and field-knowledge can impact the transfer of graphical intentions during architectural cooperative design. The analysis of 28 controlled experiments reveals what matters in transmitting architectural intents and more specifically underlines how novices’ intuitive, deductive processes based on previous and embodied experiences interestingly complement experts’ knowledge of the architectural field and its semantics. The results directly inform how we, as researchers, designers and engineers, should take advantage of both novices’ and experts’ strategies to develop tools, methods or interfaces to support next generation cooperative design. [less ▲]

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See detailAdult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling.
Goffart, Nicolas; KROONEN, Jérôme ULg; Di Valentin, Emmanuel ULg et al

in Neuro-oncology (2014)

BACKGROUND: Patients with glioblastoma multiforme (GBM) have an overall median survival of 15 months. This catastrophic survival rate is the consequence of systematic relapses that could arise from ... [more ▼]

BACKGROUND: Patients with glioblastoma multiforme (GBM) have an overall median survival of 15 months. This catastrophic survival rate is the consequence of systematic relapses that could arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. We previously demonstrated that GSCs are able to escape the tumor mass and specifically colonize the adult subventricular zones (SVZs) after transplantation. This specific localization, away from the initial injection site, therefore represents a high-quality model of a clinical obstacle to therapy and relapses because GSCs notably retain the ability to form secondary tumors. METHOD: In this work, we questioned the role of the CXCL12/CXCR4 signaling in the GSC-specific invasion of the SVZs. RESULTS: We demonstrated that both receptor and ligand are respectively expressed by different GBM cell populations and by the SVZ itself. In vitro migration bio-assays highlighted that human U87MG GSCs isolated from the SVZs (U87MG-SVZ) display stronger migratory abilities in response to recombinant CXCL12 and/or SVZ-conditioned medium (SVZ-CM) compared with cancer cells isolated from the tumor mass (U87MG-TM). Moreover, in vitro inhibition of the CXCR4 signaling significantly decreased the U87MG-SVZ cell migration in response to the SVZ-CM. Very interestingly, treating U87MG-xenografted mice with daily doses of AMD3100, a specific CXCR4 antagonist, prevented the specific invasion of the SVZ. Another in vivo experiment, using CXCR4-invalidated GBM cells, displayed similar results. CONCLUSION: Taken together, these data demonstrate the significant role of the CXCL12/CXCR4 signaling in this original model of brain cancer invasion. [less ▲]

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See detailEffect of N-acetylcysteine combined with infliximab on toxic epidermal necrolysis. A proof-of-concept study.
PAQUET, Philippe ULg; JENNES, Serge; ROUSSEAU, Anne-Françoise ULg et al

in Burns : Journal of the International Society for Burn Injuries (2014)

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See detailLe point de rosée en berne et la couche cornée hivernale.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; Delvenne, Philippe ULg

in Revue Médicale de Liège (2014), 69(2), 68-71

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed ... [more ▼]

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy. Keywords : Stratum corneum - Dew point [less ▲]

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See detailThe impact of lexical frequency on sentence comprehension in children with specific language impairment
Leclercq, Anne-Lise ULg; Majerus, Steve ULg; Jacob, Laura et al

in Research in Developmental Disabilities (2014), 35

Children with SLI generally exhibit poor sentence comprehension skills. We examined the specific impact of grammatical complexity and lexical frequency on comprehension performance, yielding contrasting ... [more ▼]

Children with SLI generally exhibit poor sentence comprehension skills. We examined the specific impact of grammatical complexity and lexical frequency on comprehension performance, yielding contrasting results. The present study sheds new light on sentence comprehension in children with SLI by investigating a linguistic factor which has attracted little research interest: the impact of the lexical frequency of known words on sentence comprehension. We also examined the impact of grammatical complexity and sentence length by independently varying these two factors. Fifteen children with SLI, 15 age- and IQ-matched controls, and 15 controls matched on lexical and grammatical skills, performed sentence comprehension tasks in which three linguistic factors were manipulated: lexical frequency (sentences containing words of either low or high lexical frequency), grammatical complexity (sentence containing either a subject relative clause or an object relative clause) and sentence length (either short or long sentences). Results indicated that children with SLI performed more poorly overall compared to age- and IQmatched children and to lexical and morphosyntactic age-matched children. However, their performance was not more affected by either sentence length or clause type than that of control children. Only lexical frequency affected sentence comprehension to a greater extent in children with SLI relative to the control groups, revealing that SLI children’s sentence comprehension abilities are particularly affected by the presence of lowfrequency but familiar words. [less ▲]

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See detailGeometric ferroelectricity in fluoroperovskites
Garcia-Castro, A. C.; Spaldin, Nicola A.; Romero, A. H. et al

in Physical Review B (2014), 89

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are ... [more ▼]

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are paraelectric (Pnma phase), we find that many fluoroperovskites have a ferroelectric instability in their high-symmetry cubic structure that is of similar amplitude to that commonly found in oxide perovskites. In contrast to the oxides, however, the fluorides have nominal Born effective charges, indicating a different mechanism for the instability.We show that the instability originates from ionic size effects, and is therefore in most cases largely insensitive to pressure and strain, again in contrast to the oxide perovskites. An exception is NaMnF3, where coherent epitaxial strain matching to a substrate with equal in-plane lattice constants destabilizes the bulk Pnma structure, leading to a ferroelectric, and indeed multiferroic, ground state with an unusual polarization/strain response. [less ▲]

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See detailLa dermocosmétique en appui de traitements oncologiques ciblés.
FRANCHIMONT, Claudine ULg; Lesuisse, Marianne; PIERARD, Gérald ULg

in Revue Médicale de Liège (2014), 69(1), 35-37

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the ... [more ▼]

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the unwanted skin conditions without interfering with the targeted therapeutic effects. However, evidence-based support for using dermocosmetic products as adjunctive cancer treatment remains scarce. It remains nonetheless that the clinical perception is unanimously favourable for such procedure. [less ▲]

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See detailEssai de synthèse de rôles de l'élevage pastoral au Sahel et en Afrique de l'Ouest
Laouali, Abdoulkadri ULg; Yamba, Boubacar; Chabi Toko, Roukayath et al

in Annales de l'Université Abdou Moumouni de Niamey, Série B Lettres et Sciences Humaines (2014), Numéro spécial

Throughout the world, livestock plays an important role in socio-economic life and dietary balance of the population especially in the Sahel and West Africa countries characterized by extensive pastoral ... [more ▼]

Throughout the world, livestock plays an important role in socio-economic life and dietary balance of the population especially in the Sahel and West Africa countries characterized by extensive pastoral farming. Across the literature, this activity appears to be subjected to various controversies including its contribution to the degradation of the environment; greenhouse gas emissions; its low economic performance; etc. This article attempts to state the debate through a literature review showing the importance of pastoral livestock in the economics of the Sahel and West Africa countries as well as in household alimentation and the fight against poverty. Also, it noticed the importance and efficiency of pastoral practice in a precariously natural environment such as the Sahel area [less ▲]

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See detailRADIOTHÉRAPIE MAMMAIRE- pret-à-porter ou sur mesure ?
COUCKE, Philippe ULg; LAKOSI, Ferenc ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 81-86

La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très ... [more ▼]

La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très bien codifiée et peut être taxée de «prêt-à-porter». Et pourtant, on est en droit de se poser la question s’il est possible de concevoir des indications de traitement «sur mesure». A ce jour, les données de la littéra - ture nous incitent à la prudence. Dans aucun cas de figure, on n’a été capable de démontrer que la radiothérapie pouvait être éliminée de l’approche thérapeutique sans pour autant risquer une augmentation significative du taux de rechute locale. Même si on considère que la radiothérapie adjuvante est une approche standard après une chirurgie conservatrice, il n’en reste pas moins qu’il persiste un certain nombre de questions ouvertes. Ces traitements actiniques pourraient être modulables en fonction des caractéristiques des patientes et des tumeurs. Idéalement, nous aimerions disposer de mar - queurs pronostiques et prédictifs robustes afin de détermi - ner qui il faut soumettre à ce traitement adjuvant. Peut-être que des signatures géniques vont permettre de sélectionner les patientes. Ces signatures géniques ne font pas l’unanimité quant à leur réelle portée clinique [less ▲]

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See detailUncertainty assessment of ephemeral gully identification, characteristics and topographic threshold when using aerial photographs in agricultural settings
Maugnard, Alexandre; Cordonnier, Hélène; Degré, Aurore ULg et al

in EARTH SURFACE PROCESSES AND LANDFORMS (2014)

Manual digitizing on aerial photographs is still commonly used for characterizing gully erosion over large areas. Even when automated detection procedures are implemented, manual digitizing is frequently ... [more ▼]

Manual digitizing on aerial photographs is still commonly used for characterizing gully erosion over large areas. Even when automated detection procedures are implemented, manual digitizing is frequently being resorted to in order to constitute reference datasets used for training and validation. In both cases, manual digitizing entails some subjective decisions on behalf of the operator, which introduces uncertainty into the resulting datasets. To assess the magnitude of this uncertainty, 11 experienced operators were asked to digitize and classify ephemeral gullies (EGs) on cropland following a standardized methodology. The resulting 11 datasets were compared in terms of number, type and location of EGs. Furthermore, for EGs located on a welldefined runoff flow concentration axis, the slope versus contributing area topographic thresholds required for initiating gully channels were assessed using four thresholding methods, and compared across the 11 datasets. The operators identified 259 different EGs. However, the number (52–139) and sum total length (8.9–23.7 km) of EGs varied widely across operators. Only 34% of the EGs were digitized by more than half of the operators, and 7% were identified by all. Identification of EGs located on a well-defined flow concentration axis proved least subjective. The longer the EG and the more fields the EG crossed, the larger the number of operators that were able to identify it. EGs were also most easily identified when located in sugar beet fields as compared to other crops. EG classification and topographic threshold lines were also found to be strongly operator-dependent. Quantile regression appeared to be one of the most robust thresholding methods. Operator subjectivity when digitizing EGs on orthophotographs introduces uncertainty that should be taken into account in future remote sensing-based studies of EG erosion whenever they rely, in part or in full, on manual photograph interpretation. [less ▲]

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See detailFrom reporting incidents in a radiation therapy department to enterprise risk management (ERM) based on the European Foundation for Quality Management philosophy (EFQM)
COUCKE, Philippe ULg; BOGA, Deniz ULg; LENAERTS, Eric ULg et al

in International Journal of Healthcare Technology & Management (2014), 7(2), 127-131

The radiation therapy department (RTD) initiated in 2009 a policy of open and transparent reporting of events not harming (near incidents) and potentially harming patients (incidents and accidents). This ... [more ▼]

The radiation therapy department (RTD) initiated in 2009 a policy of open and transparent reporting of events not harming (near incidents) and potentially harming patients (incidents and accidents). This approach was immediately followed by the leader’s decision to engage towards the European Foundation for Quality Management (EFQM) excellence model. The EFQM approach structured the journey of the RTD to enterprise risk management. We intend to demonstrate in the five main fields of the EFQM approach (leadership, policy and strategy, people/personnel, partnership and resources, processes), how the journey to continuous improvement in quality and safety did evolve and was accelerated in RTD. The assessment made by external evaluators evolved from a minimum of 90 points (basic requirement for level 1 in 2009) to a at least 180 points (basic requirement for level 2 in 2011), to reach 400 points in 2013 (270 required for level 3 and 450 required for level 4). [less ▲]

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See detailLes lipopeptides d’origine microbienne, des agents de biocontrôle aux multiples facettes
Jacques, P.; Deravel, J.; Coutte, F. et al

in Phytoma (2014), 672

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See detailUne Histoire d'hypophyse, évolution des représentations et des concepts au fil du temps.
JEDIDI, Haroun ULg; JEDIDI, Zayd ULg; BECKERS, Albert ULg

in Revue Médicale de Liège (2014)

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez ... [more ▼]

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez paradoxal de constater que malgré l’importance de ce système, celui-ci ait été presque complètement méconnu par les physiologistes des siècles passés. En nous basant sur les conceptions physiologiques des médecins philosophes de l’antiquité puis du moyen-âge et de la renaissance nous tenterons de comprendre pourquoi le rôle de l’hypophyse a été si longtemps méconnu. [less ▲]

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See detailSpatial patterns and morphology of termite ( Macrotermes falciger ) mounds in the Upper Katanga, D.R. Congo
Mujinjya, Baile Baziraké; Adam, Marielle; Mees, Florias et al

in Catena (2014), 114

This study examines the spatial distribution patterns and morphological characteristics of Macrotermes falciger mounds in the peri-urban zone of Lubumbashi, D.R. Congo. Spatial patterns of mounds were ... [more ▼]

This study examines the spatial distribution patterns and morphological characteristics of Macrotermes falciger mounds in the peri-urban zone of Lubumbashi, D.R. Congo. Spatial patterns of mounds were assessed using high-resolution satellite images for 24 plots of variable size (3 to 27 ha). Soil morphological features were described for five termite-mound profiles of 5 to 9 m depth/height. A mean areal number density of 2.9 ± 0.4 mounds ha−1 is estimated for the degraded miombo woodland of the study area. Spatial statistical analyses document that termite mounds are regularly distributed in all studied plots. The overall mean nearest-neighbour distance between termite mounds is 44.6 ± 0.6 m. The high relative number of inactive mounds in the region, with regular distribution patterns, suggests that current termite mound occurrences are largely relict features.There are no clear indications for an impact of the nature of the parent material on the spatial distribution of the mounds. One aspect of differences in morphology between the studied mounds is that the stone layer occurs at greater depth in topographic low areas than at crest and slope positions. This is interpreted as being mainlyconditionedbyerosion.Mn–Fe oxideconcentrationsoccurringinallstudiedtermite moundprofiles reflect a seasonally high perched water table beneath the mound, which is more pronounced at lower landscape positions. In summary, mound positions in the habitat are consistent with intraspecific competition rather than soil and substrate characteristics as controlling factor, whereas variation in morphological characteristics between termite-mound profiles appears to be a function of the parent material [less ▲]

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See detailImprovement of fermentative biohydrogen production by Clostridium butyricum CWBI1009 in sequenced-batch, horizontal fixed bed and biodisc-like anaerobic reactors with biomass retention
Hiligsmann, Serge ULg; Beckers, Laurent; Masset, Julien et al

in International Journal of Hydrogen Energy (2014), 39

A horizontal tubular fixed bed bioreactor (HFBR) and an anaerobic biodisc-like reactor (AnBDR) were designed to both fix Clostridium biomass and enable rapid transfer of the hydrogen produced to gas phase ... [more ▼]

A horizontal tubular fixed bed bioreactor (HFBR) and an anaerobic biodisc-like reactor (AnBDR) were designed to both fix Clostridium biomass and enable rapid transfer of the hydrogen produced to gas phase in order to decrease the strong effect of H2 partial pressure and H2 supersaturation on the performances of Clostridium strains. The highest H2 production rate (703 mL H2/L.h) and yield (302 mL/g glucose consumed i.e. 2.4 mol/mol) with the pure culture were recorded in the AnBDR with 300 mL culture medium (total volume 2.3 L) at pH 5.2 and a glucose loading rate of 2.87 g/L.h. These results are about 2.3 and 1.3-fold higher than those achieved in the same bioreactor with 500 mL liquid medium and with the same glucose consumption rate. Therefore, our experimentations and a short review of the literature reported in this paper emphasize the relevance of performing bioreactors with high L/G transfer. [less ▲]

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See detailAUTOMATISATION DE LA DÉTECTION DES CRATÈRES LUNAIRES SUR DES IMAGES ET MNT PLANÉTAIRES
Renson, Pierre; Poncelet, Nadia; Vandeloise, Yannick et al

in Bulletin de la Société Géographique de Liège (2014), 61

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images ... [more ▼]

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images and DTM). In this context, the automation of the process is essential because the craters represent a landing risk and landmarks for visual navigation. It is also the key challenge because it is difficult to develop high level automatic processing comparable to the thinking carried out in a traditional visual interpretation. Our method automatically establishes a semantic diagnosis based on the combination of crater descriptors computed on the planetary products used. Finally, this application is part of a decision support tool and an assessment system of landing and mission survival risks. It also aims to feed a landmarks database for automatic visual navigation of a lunar landing spacecraft. [less ▲]

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See detailL’« originalité » perceptive d’un sujet pervers au test de Rorschach
Englebert, Jérôme ULg

in Evolution Psychiatrique (2014), 79(3), 429-441

The author starts with a discussion about two notions appearing into the Rorschach test: the perception and the apperception. By this way, it is suggest ways for a phenomenological study of the Rorschach ... [more ▼]

The author starts with a discussion about two notions appearing into the Rorschach test: the perception and the apperception. By this way, it is suggest ways for a phenomenological study of the Rorschach test. These proposals are consistent with those of the Comprehensive System (Proposed by John E. Exner). Then the author proposes a protocol analyzing of a patient with a perverse psychological functioning. In one hand, the result obtained by the Form Quality (FQ) is detailed in particular regarding to the status of unusual perceptions. According to the Comprehensive System proposed by J.E. Exner, a significant proportion of responses "u" (46% for this protocol) indicates that the person is not influenced by any social request or any expectation and some of his behaviors could ignore or avoid any question about social convention. From an other point of view, when analyzing these data, an adaptive dimension for these unusual perceptions is identified. The pervert perceives the stimuli that "really exists" according to him not everyone can perceive it. This advantage allows a better adaptation to the environment and the ability to change this environment. The manipulation (a particular skill that is most of the time attributed to the perverse person) is probably a consequence of having an original perception of reality. It is also discussed the interpretation of the "anatomical content" in connection with this adaptive hypothesis. In addition, the author also discusses a particular answer of the protocol: the answer "shoes" that presents a specific perceptual characteristic. [less ▲]

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See detailPharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor.
Scheen, André ULg

in Clinical pharmacokinetics (2014), 53(3), 213-25

Empagliflozin is an orally active, potent and selective inhibitor of sodium glucose co-transporter 2 (SGLT2), currently in clinical development to improve glycaemic control in adults with type 2 diabetes ... [more ▼]

Empagliflozin is an orally active, potent and selective inhibitor of sodium glucose co-transporter 2 (SGLT2), currently in clinical development to improve glycaemic control in adults with type 2 diabetes mellitus (T2DM). SGLT2 inhibitors, including empagliflozin, are the first pharmacological class of antidiabetes agents to target the kidney in order to remove excess glucose from the body and, thus, offer new options for T2DM management. SGLT2 inhibitors exert their effects independently of insulin. Following single and multiple oral doses (0.5-800 mg), empagliflozin was rapidly absorbed and reached peak plasma concentrations after approximately 1.33-3.0 h, before showing a biphasic decline. The mean terminal half-life ranged from 5.6 to 13.1 h in single rising-dose studies, and from 10.3 to 18.8 h in multiple-dose studies. Following multiple oral doses, increases in exposure were dose-proportional and trough concentrations remained constant after day 6, indicating a steady state had been reached. Oral clearance at steady state was similar to corresponding single-dose values, suggesting linear pharmacokinetics with respect to time. No clinically relevant alterations in pharmacokinetics were observed in mild to severe hepatic impairment, or in mild to severe renal impairment and end-stage renal disease. Clinical studies did not reveal any relevant drug-drug interactions with several other drugs commonly prescribed to patients with T2DM, including warfarin. Urinary glucose excretion (UGE) rates were higher with empagliflozin versus placebo and increased with dose, but no relevant impact on 24-h urine volume was observed. Increased UGE resulted in proportional reductions in fasting plasma glucose and mean daily glucose concentrations. [less ▲]

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See detailPhysical modelling of water, fauna and flora: knowledge gaps, avenues for future research and infrastructural needs
ROBERT, THOMAS; JOHNSON, MATTHEW; FROSTICK, LYNNE et al

in Journal of Hydraulic Research (2014), 52

Physical modelling is a key tool for generating understanding of the complex interactions between aquatic organisms and hydraulics, which is important for management of aquatic environments under ... [more ▼]

Physical modelling is a key tool for generating understanding of the complex interactions between aquatic organisms and hydraulics, which is important for management of aquatic environments under environmental change and our ability to exploit ecosystem services. Many aspects of this field remain poorly understood and the use of physical models within eco-hydraulics requires advancement in methodological application and substantive understanding. This paper presents a review of the emergent themes from a workshop tasked with identifying the future infrastructure requirements of the next generation of eco-hydraulics researchers. The identified themes are: abiotic factors, adaptation, complexity and feedback, variation, and scale and scaling. The paper examines these themes and identifies how progress on each of them is key to existing and future eðorts to progress our knowledge of eco-hydraulic interactions. Examples are drawn from studies on biofilms, plants, and sessile and mobile fauna in shallow water fluvial and marine environments. Examples of research gaps and directions for educational, infrastructural and technological advance are also presented. [less ▲]

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See detailMemory Reactivation During Rapid Eye Movement (REM) Sleep Promotes Its Generalization and Integration in Cortical Stores
Sterpenich, Virginie; Schmidt, Christina ULg; Albouy, Genevièvre et al

in Sleep (2014), 37(6), 1061-1075

Memory reactivation appears to be a fundamental process in memory consolidation. Here, we tested the influence of memory reactivation during REM sleep on memory performance and brain responses at ... [more ▼]

Memory reactivation appears to be a fundamental process in memory consolidation. Here, we tested the influence of memory reactivation during REM sleep on memory performance and brain responses at retrieval in healthy human participants. Auditory cues were associated with pictures of faces during their encoding. These memory cues delivered during REM sleep enhanced subsequent accurate recollections but also false recognitions. These results suggest that reactivated memories interacted with semantically-related representations, and induced new creative associations, which subsequently reduced the distinction between new and previously encoded exemplars. Cues had no effect if presented during stage 2 sleep, or if they were not associated with faces during encoding. Functional MRI revealed that following exposure to conditioned cues during REM sleep, responses to faces during retrieval were enhanced both in a visual area and in a cortical region of multisensory (auditory-visual) convergence. These results show that reactivating memories during REM sleep enhances cortical responses during retrieval, suggesting the integration of recent memories within cortical circuits, favoring the generalization and schematization of the information. [less ▲]

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See detailExpression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis
CREVECOEUR, Julie ULg; Kaminski, RM; Rogister, Bernard ULg et al

in Neuropathology & Applied Neurobiology (2014), 40(2), 191-204

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See detailLongitudinal assessment of progress in reasoning capacity and relation with self-estimation of knowledge base
Collard, Anne ULg; Mélot, France ULg; Bourguignon, Jean-Pierre ULg

in Assessment & Evaluation in Higher Education (2014)

The aim of the study was to investigate progress in reasoning capacity and knowledge base appraisal in a longitudinal analysis of data from summative evaluation throughout a medical problem-based learning ... [more ▼]

The aim of the study was to investigate progress in reasoning capacity and knowledge base appraisal in a longitudinal analysis of data from summative evaluation throughout a medical problem-based learning curriculum. The scores in multidisciplinary discussion of a clinical case and multiple choice questionnaires (MCQs) were studied longitudinally for 213 students from years 2 to 5. The capacity of core knowledge delimitation was calculated as the difference between the levels of average ascertainment degrees given for correct and incorrect answers at MCQ. For both multidisciplinary discussion of a clinical case evaluation and self-estimation of core knowledge, the capacity increases throughout the curriculum. The reasoning capacity assessed through multidisciplinary discussion of a clinical case is positively correlated with MCQ scores and the capacity to discriminate the mastered core knowledge. In conclusion, this study indicates that self-estimation of core knowledge is associated with an increase in reasoning performance through a well-organised knowledge base. Since that ability is related to success or failure, it is suggested that student awareness about delimitation of mastered core knowledge is considered as part of learning. [less ▲]

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See detailCervical cancer and HPV: Awareness and vaccine acceptability among parents in Morocco.
Mouallif, Mustapha; Bowyer, Harriet L.; Festali, Soukaina et al

in Vaccine (2014), 32(3), 409-16

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since ... [more ▼]

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since 2008 but there are no available data on their acceptability. This study aimed to assess awareness of HPV and the vaccine, and to identify factors associated with acceptability of the vaccine among parents in Morocco. We carried out a questionnaire-based survey using face-to-face interviews in a sample of 852 parents (670 mothers and 182 fathers) with at least one unmarried daughter </=26 years. We collected data within public and private health centres and clinics in four regions in Morocco between July and August 2012. The main outcome measure was parental acceptability of the HPV vaccine for their daughter(s). Responses revealed very low awareness of HPV infection (4.7%) and the HPV vaccine (14.3%). None of the participants had vaccinated their daughter(s) against HPV and vaccine acceptability was low among mothers (32%) and fathers (45%). Higher education and income, previous awareness of the HPV vaccine and endorsement of the belief that a recommendation from the Ministry of Health or a doctor to have the vaccine would be encouraging, were associated with mothers' HPV vaccine acceptability. Non-acceptability among mothers was associated with having more than two daughters, believing the vaccine was expensive, lack of information and believing that whatever happens to an individual's health is God's will. The only factor associated with the fathers' acceptability of the vaccine was the cost of the vaccine. Increasing HPV and HPV vaccine awareness through educational campaigns, along with active recommendation by physicians and a publically funded vaccination programme could increase parental acceptability of the HPV vaccine in Morocco. [less ▲]

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See detailCharacterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogel
Haghgoo, Majid; Yousefi, Ali Akbar; Zohouriaan Mehr, Mohammad Jalal et al

in Microporous and Mesoporous Materials (2014), 184

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See detailComment definir une circulation extracorporelle de qualite ?
Blaffart, F.; Defraigne, Jean-Olivier ULg

in Annales francaises d'anesthesie et de reanimation (2014)

Extracorporeal circulation (ECC) has to ensure homeostasis of the patient and to minimize pathophysiological disorders inherent in the technique. However, we cannot dissociate it from the surgery and ... [more ▼]

Extracorporeal circulation (ECC) has to ensure homeostasis of the patient and to minimize pathophysiological disorders inherent in the technique. However, we cannot dissociate it from the surgery and anesthesia knowing that the discipline involves a close partnership with these stakeholders. The purpose of this publication is to review the essential elements that at present can contribute to the quality of the CEC and suggest improvements and developments to be implemented in this area. [less ▲]

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See detailGenome encyclopaedia of type strains of the genus Bifidobacterium
Milani, Christian; Lugli, Gabriele; Duranti, Sabrina et al

in Applied and Environmental Microbiology (2014)

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See detailPhosphine- and ammonium-functionalized ordered mesoporous carbons as supports for cluster-derived metal nanoparticles
Vidick, Deborah; Léonard, Alexandre ULg; Poleunis, Claude et al

in Catalysis Today (2014), 235

An ordered mesoporous carbon (OMC) was functionalized with ammonium or chelating phosphine ligands. In both cases, the functionalization procedure started by oxidation by nitric acid treatment, followed ... [more ▼]

An ordered mesoporous carbon (OMC) was functionalized with ammonium or chelating phosphine ligands. In both cases, the functionalization procedure started by oxidation by nitric acid treatment, followed by activation of surface carboxylic acid groups with thionyl chloride, then formation of amide bonds with diamines. The pendant amine groups were then either quaternized or further reacted with phosphine. The introduced functions were used as anchors for molecular mixed-metal clusters. These organometallic grafted species could then be thermally transformed into hetero-metallic nanoparticles (NP) embedded within the mesoporous framework. The NP/OMC nanocomposites could find application in hydrogenation, heterogeneous catalysis or as electrodes in fuel cells. [less ▲]

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See detailLateral Magnetic Near-Field Imaging of Plasmonic Nanoantennas With Increasing Complexity
Denkova, D.; Verellen, N.; Silhanek, Alejandro ULg et al

in Small : Nano Micro (2014)

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field ... [more ▼]

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field interactions between their building blocks. While the electric field distributions and, respectively, the electric interactions of different nanostructures can be routinely measured, for example, by scattering near-field microscopy, only recently experimental methods for imaging the magnetic field distributions became available. In this paper, we provide direct experimental maps of the lateral magnetic near-field distributions of variously shaped plasmonic nanoantennas by using hollow-pyramid aperture scanning near-field optical microscopy (SNOM). We study both simple plasmonic nanoresonators, such as bars, disks, rings and more complex antennas. For the studied structures, the magnetic near-field distributions of the complex resonators have been found to be a superposition of the magnetic near-fields of the individual constituting elements. These experimental results, explained and validated by numerical simulations, open new possibilities for engineering and characterization of complex plasmonic antennas with increased functionality. [less ▲]

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See detailLa radicalité politique au bout du travail. Du suicide des ouvriers aux suicides en séries des employés
Cormann, Grégory ULg

in Quaderni : la Revue de la Communication (2014), 84

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See detailImpairment of symbiont photosynthesis increases host cell proliferation in the epidermis of the sea anemone Aiptasia pallida
Fransolet, David ULg; Roberty, Stéphane ULg; Plumier, Jean-Christophe ULg

in Marine Biology (2014)

Corals exposed to environmental stresses need to engage appropriate physiological strategies to survive. Here we examined tissue modifications following algal dysfunction. Aiptasia pallida was exposed ... [more ▼]

Corals exposed to environmental stresses need to engage appropriate physiological strategies to survive. Here we examined tissue modifications following algal dysfunction. Aiptasia pallida was exposed during one week to 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), the herbicide called Diuron. DCMU treatment produced a drastic loss in photosynthetic efficiency and a subsequent diminution of algae density over the following days. Cell proliferation evaluated by measuring the number of cells labeled with a thymidine analogue (EdU) revealed a significant increase in EdU+ cells in the epidermis after one week of DCMU incubation and in the gastrodermis at four weeks. TUNEL histology showed that the extent of cell death was however similar in the epidermis of control and treated specimens. In addition we noticed a significant effect of DCMU treatment on the density of epidermal mucocytes after one, two and four weeks. These results show that inhibition of Symbiodinium photosynthesis in the absence of any known direct effect of DCMU on host cells can induce an increase of epidermal host cell proliferation in both the epidermis and the gastrodermis. While new host gastrodermal cells are likely to promote tissue regeneration in order to recruit new algae, the new host epidermal cells may contribute to tissue adaptation following a decrease in energy income. Some of these new epidermal cells, such as mucocytes, may contribute to an eventual increase of the host heterotrophic ability until restoration of algal autotrophic contribution. [less ▲]

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See detailSynthese bibliographique de l'influence du procédé d'extraction et de purification sur les caractéristiques et les propriétés d'une gomme de caroube
Gillet, Sébastien ULg; Simon, mathilde; Paquot, Michel ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(1),

The carob tree is a species cultivated, in mediterranean countries, for its seeds. These seeds contain an endosperm rich in galactomannans used by the food industry for its texturing properties. After ... [more ▼]

The carob tree is a species cultivated, in mediterranean countries, for its seeds. These seeds contain an endosperm rich in galactomannans used by the food industry for its texturing properties. After harvesting, the seeds pass through a decutilation and a degermination. Cleaned endosperms are then milled to give crude locust bean gum. The purification step consists in a flour solubilization and then a precipitation of the galactomannans. Purification influences the characteristics of the resulting gum. The solubilization temperature is the parameter that affects the most on the final characteristics of the product. If it is hot or cold, galactomannans with different structural characteristics (and thus very different physical properties in aqueous solutions) will be selected. [less ▲]

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See detailLe myélome multiple asymptomatique : le paysage thérapeutique change
CAERS, Jo ULg; BEGUIN, Yves ULg

in Oncol. Hematol. (2014), 8

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade ... [more ▼]

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade précurseur du myélome multiple. En moyenne, les patients présentant un myélome asymptomatique ont un risque annuel de progression en myélome déclaré de 10%. Différents facteul"s ont été combinés dans des modélisations pronostiques: le rapport des chaînes légères, les anomalies radiologiques, la présence d'une gammapathie évolutive et l'infiltration médullaire > 60% ont récemment été identifiés comme facteurs prédictifs d'une progression précoce pour lesquels certains auteurs évoquent la mise en roùte d'un traitement anti-myélome. Cette stratégie thérapeutique précoce a démontré son efficacité dans une étude randomisée qui comparait un traitement par lénalidornide et dexaméthasone avec une approche attentiste chez des patients à risque. [less ▲]

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See detailHerschel observations of gas and dust in comet C/2006 W3 (Christensen) at 5 AU from the Sun
de Val-Borro, M; Bockelée-Morvan, D; Jehin, Emmanuel ULg et al

in Astronomy and Astrophysics (2014)

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See detailA frontal approach to hex-dominant mesh generation
Baudouin, Tristan Carrier; Remacle, Jean-François; Marchandise, Emilie et al

in Advanced Modeling and Simulation in Engineering Sciences (2014), 1(1), 1-30

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See detailGenetic parameters for direct and maternal calving ease in Walloon dairy cattle based on linear and threshold models
Vanderick, Sylvie ULg; Troch, Thibault ULg; Gillon, Alain et al

in Journal of Animal Breeding & Genetics (2014), in press

Calving ease scores from Holstein dairy cattle in the Walloon Region of Belgium were analysed using univariate linear and threshold animal models. Variance components and derived genetic parameters were ... [more ▼]

Calving ease scores from Holstein dairy cattle in the Walloon Region of Belgium were analysed using univariate linear and threshold animal models. Variance components and derived genetic parameters were estimated from a dataset including 33,155 calving records. Included in the models were season, herd and sex of calf age of dam classes group of calvings interaction as fixed effects, herd year of calving, maternal permanent environment and animal direct and maternal additive genetic as random effects. Models were fitted with the genetic correlation between direct and maternal additive genetic effects either estimated or constrained to zero. Direct heritability for calving ease was about 8% with linear models and about 12% with threshold models. Maternal heritabilities were about 2% and 4%, respectively. Genetic correlation between direct and maternal additive effects was found to be not significantly different from zero. Models were compared in terms of goodness of fit and predictive ability. Criteria of comparison such as mean squared error, correlation between observed and predicted calving ease scores as well as between estimated breeding values were estimated from 85,118 calving records. The results provided few differences between linear and threshold models even though correlations between estimated breeding values from subsets of data for sires with progeny from linear model were 17% and 23 % greater for direct and maternal genetic effects, respectively, than from threshold model. For the purpose of genetic evaluation for calving ease in Walloon Holstein dairy cattle, the linear animal model without covariance between direct and maternal additive effects was found to be the best choice. [less ▲]

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See detailPopular Economy in Santiago de Chile: State of Affairs and Challenges
Bauwens, Thomas ULg; Lemaître, Andreia

in World Development : The Multi-Disciplinary International Journal Devoted to the Study and Promotion of World Development (2014), 64

Do informal initiatives share a capitalist spirit of entrepreneurship? This article attempts to answer this question, using a “popular economy” analytical framework and focusing on the case of Chile ... [more ▼]

Do informal initiatives share a capitalist spirit of entrepreneurship? This article attempts to answer this question, using a “popular economy” analytical framework and focusing on the case of Chile. First, we present the context of the research, namely the economic and political evolutions in Chile since the 1970s and their effects on the popular economy. Then, we seek to answer the original question, relying on in-depth case studies of so-called “popular economy organizations”. Our research shows that their socio-economic logics significantly differ from those of the traditional capitalist firm. Our observations also suggest important differences between current and older initiatives. [less ▲]

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See detailIn Vitro and In Vivo Characterization of Plant Growth Promoting Bacillus Strains Isolated from Extreme Environments of Eastern Algeria.
Ait-Kaki, Asma; Kacem-Chaouche, Noreddine; Ongena, Marc ULg et al

in Applied biochemistry and biotechnology (2014), 172

This report is to our knowledge the first to study plant growth promotion and biocontrol characteristics of Bacillus isolates from extreme environments of Eastern Algeria. Seven isolates of 14 (50 %) were ... [more ▼]

This report is to our knowledge the first to study plant growth promotion and biocontrol characteristics of Bacillus isolates from extreme environments of Eastern Algeria. Seven isolates of 14 (50 %) were screened for their ability to inhibit growth of some phytopathogenic fungi on PDA and some roots exudates. The bacteria identification based on 16S r-RNA and gyrase-A gene sequence analysis showed that 71 % of the screened isolates belonged to Bacillus amyloliquefaciens and the rest were closely related to B. atrophaeus and B. mojavensis. Most of them had high spore yields (22 x 108-27 x 108 spores/ml). They produced protease and cellulase cell wall-degrading enzymes while the chitinase activity was only observed in the B. atrophaeus (6SEL). A wide variety of lipopeptides homologous was detected by liquid chromatography-electrospray ionization-mass spectrometry analysis. Interestingly, some additional peaks with new masses were characterized, which may correspond to new fengycin classes. The isolates produced siderophores and indole-3- acetic acid phytohormone. The greenhouse experiment using a naturally infested soil with Sclerotonia sclerotiorum showed that the B. atrophaeus (6SEL) significantly increased the size of the chickpea plants and reduced the stem rot disease (P < 0.05). These results suggest that these isolates may be used further as bio-inoculants to improve crop systems. [less ▲]

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See detailIdentification of 1-methyloctyl butanoate as the major sex pheromone component from females of the saddle gall midge, Haplodiplosis marginata (Diptera: Cecidomyiidae)
Censier, Florence ULg; Fischer, Christophe ULg; Pascal, Laurent et al

in Chemoecology (2014)

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective monitoring tool of saddle gall midge flights is needed in order to understand the enigmatic population dynamics of this pest, and to design an integrated management strategy. Therefore, volatile compounds emitted by females (alkan-2-ols and alk-2-yl butanoates) were identified, and the chirality of the emitted esters was determined to be the R absolute configuration. In field-trapping experiments, racemic non-2-yl butanoate attracted substantial numbers of H. marginata males. Thus, this compound will be useful in baited traps for monitoring seasonal flight patterns, and improving integrated management of the saddle gall midge in agricultural systems. [less ▲]

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See detailDermatophytes transmis par les animaux domestiques
Monod, M; Fratti, B; Mignon, Bernard ULg et al

in Revue Médicale Suisse (2014), 10

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See detailSpread of hatch and delayed feed access affect post hatch performance of female broiler chicks up to day 5.
Wang, Y.; Li, Yue; Willems, E. et al

in Animal (2014)

It is not rare that newly hatched chicks remain without feed for about 24 to 48 h before they are placed on farms due to a series of logistic operations. Furthermore, the spread in hatching time can also ... [more ▼]

It is not rare that newly hatched chicks remain without feed for about 24 to 48 h before they are placed on farms due to a series of logistic operations. Furthermore, the spread in hatching time can also mount up to 30 to 48 h for late v. early hatchers. In other words, the practice is a complex combination of spread of hatch and delayed feed access. The present study was aimed to investigate the combined effects of hatching time with a delay in feed access of 48 h, starting from their hatch-time (biological age). When chicks had access to feed immediately after hatch, late hatchers had a higher feed intake and relative growth rate up to day 5 compared with their early hatched counterparts. Feed deprivation during the first 48 h resulted in retarded early growth rate, which was further aggravated by an impaired feed intake after refeeding. In addition, the differential effects of hatching time on relative growth rate and feed intake observed in immediately fed chicks were eliminated by the 48 h feed delay. The yolk utilization after hatch was faster for the late hatchers up to biological day 2 regardless of the feeding treatments. Hatching muscle glycogen content was higher in the late hatchers compared with that of their early counterparts at hatch and at biological day 2 independent of feeding treatment. Moreover, the liver glycogen content of the late hatchers was also higher at hatch. For the immediately fed chicks, the proportional breast muscle weight of the late hatchers was higher at biological day 2 and 5. For the starved chicks, on the other hand, this effect was only observed after they had access to feed (biological day 5). The different plasma T3 levels at hatch may have contributed to the different post hatch performance. It is concluded that the spread of hatch influenced post hatch performance, especially appetite and growth at least until day 5. Moreover, the delay in feed access interacted with the hatching time and caused adverse effects on the post hatch performance. [less ▲]

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See detailPlace de l’agriculture itinérante familiale dans la foresterie communautaire au Gabon
Meunier, Quentin; Boldrini, Sylvie; Moumbogou, Carl et al

in Bois et Forêts des Tropiques (2014), 319(1), 65-69

L’agriculture itinérante reste un système de production partagé par une grande majorité de groupes ethnolinguistiques, et appelé à se maintenir au Gabon. Elle s’exprime généralement dans un rayon de cinq ... [more ▼]

L’agriculture itinérante reste un système de production partagé par une grande majorité de groupes ethnolinguistiques, et appelé à se maintenir au Gabon. Elle s’exprime généralement dans un rayon de cinq kilomètres autour de l’unité de résidence. Au Gabon, cette zone est précisément celle destinée à accueillir depuis fin 2013 les premières forêts communautaires. Les préceptes de durabilité qui sous-tendent la notion de forêt communautaire impliquent le maintien d’un couvert forestier et pourraient entrer en contradiction avec la pratique de cette agriculture itinérante. Celle-ci prélève en effet, à chaque saison, un volume de bois soustrait au potentiel du massif concerné. Les plans simples de gestion des forêts communautaires prévoient une série agricole pour ne pas mettre en concurrence deux activités sur un même espace. Cela permet également de reconnaître la place socio-économique importante de l’agriculture en milieu rural. L’agroforesterie est une des clés pour articuler l’agriculture familiale et l’exploitation de la forêt communautaire. Conserver sur pied des arbres d’intérêts économique, social ou environnemental épargne d’une part de pénibles travaux d’abattage et, d’autre part, limite quantitativement l’impact de la coupe et du brûlis qui n’est plus systématique. L’introduction d’essences utiles, rares, protégées ou encore de bois d’œuvre permet également d’élever la valeur économique et patrimoniale des parcelles agricoles tout en répondant aux exigences en matière de conservation et de durabilité du plan simple de gestion de la forêt communautaire. Par ce biais, l’agriculture familiale coutumière est pérennisée et sécurisée dans l’enceinte d’une portion de forêt légalement reconnue tandis que les techniques culturales y sont optimisées. [less ▲]

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See detailProblème de la Mode
Badir, Sémir ULg

in Actes Sémiotiques (2014), 117

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See detailObservation <–> Text(e) <–> Culture. Introduction
Badir, Sémir ULg

in Semiotica (2014), 198

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See detailLa modélisation à l’aide du modèle SWAT des flux hydriques et du transport en suspension sur le bassin versant de la vallée de l’oued EL-Hachem
Tadrist, Nassima ULg; Debauche, Olivier ULg

in Revue des Régions Arides (2014)

Dans le Maghreb, les barrages souffrent régulièrement d’un envasement excessif lié aux problèmes d’érosion présent dans les impluviums situés en amont des barrages. Les origines de cette érosion sont ... [more ▼]

Dans le Maghreb, les barrages souffrent régulièrement d’un envasement excessif lié aux problèmes d’érosion présent dans les impluviums situés en amont des barrages. Les origines de cette érosion sont multiples : aménagement du territoire, déforestation, affectation des terres,… L’hydrologie couplée aux systèmes d’informations géographiques permet à l’aide de modèles distribués et physiquement basés de prédire l’évolution de l’envasement des barrages. L’application de ces modèles en Algérie permettra à terme, de prédire l’impact d’aménagement anti érosifs, de schémas d’aménagement du territoire sur l’envasement des barrages en estimant précisément la quantité de sédiments produit par l’érosion par ruissellement ainsi que le taux de remplissage. Une méthodologie basée sur les données cartographiques (modèle numérique de terrain, carte pédologie, carte géologie et la cartographie d’occupation du sol) ainsi que les données météorologiques journalières (température, humidité relative, vitesse du vent, radiation solaire) est en cours d’élaboration et de test sur le barrage de Bourkourdane. Cette méthodologie utilise le modèles SWAT Le modèle SWAT est utilisé pour prédire la quantité de sédiment s’accumulant dans le barrage, les flux hydriques débit entrants, sortants, ainsi que les volumes d’eau et de sédiments stockés dans le barrage. Une gestion adéquates des lâchers, couplée à une meilleure gestion de l’érosion en amont du barrage permettra d’allonger la durée de vie des barrages Algériens. Plus particulièrement pour le barrage de Boukourdane, une amélioration de la gestion des lâchers est primordiale pour améliorer la recharge de la nappe, lutter contre l’intrusion des eaux marines, et prévenir l’accumulation des particules fines qui réduisent la perméabilité du sol. [less ▲]

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See detailThree species for the price of one within the moss Homalothecium sericeum s.l.
Hedenäs, Lars; Desamore, Aurélie ULg; Laenen, Benjamin ULg et al

in Taxon (2014), 63

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See detailUnique recurrence patterns of cervical intraepithelial neoplasia following excision of the squamo-columnar junction.
Herfs, Michael ULg; SOMJA, Joan ULg; Howitt, Brooke E. et al

in International journal of cancer. Journal international du cancer (2014)

Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamo-columnar junction (SCJ) and suggest that these cells may not ... [more ▼]

Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamo-columnar junction (SCJ) and suggest that these cells may not regenerate following excision (LEEP). This study addressed the impact of SCJ excision on the temporal dynamics, histologic and viral (HPV) characteristics of recurrent CIN. One hundred thirty one consecutive patients treated by excision and attending follow-up visits were enrolled. We compared recurrent and initial CIN with attention to excision margins, timing of recurrence, CIN grade, HPV types, p16 immunophenotype, and SCJ immunophenotype. During the follow-up period (up to four years), sixteen (12.2%) recurrences were identified. Four (25%) were identified at the first follow-up visit, closely resembled the initial CIN 2/3 in grade and HPV type, and were typically SCJ marker positive [SCJ(+)], suggesting non-excised (residual) disease. Twelve (75%) manifested after the first postoperative visit and all were in the ectocervix or in mature metaplastic epithelium. All of the 12 delayed recurrences were classified as CIN 1 and were SCJ (-). Nine of 11 SCJ (-) recurrences (82%) followed regressed spontaneously. Taken together, these results show that new lesions developing from any HPV infection are delayed and occur within the ectocervix or metaplastic epithelium. This dramatically lower risk of CIN 2/3 following successful SCJ excision suggests that removal of the SCJ could be a critical variable in reducing the risk of subsequent CIN 2/3 and cervical cancer. (c) 2014 Wiley Periodicals, Inc. [less ▲]

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See detailLes effets du vieillissement normal et pathologique sur la cognition
Collette, Fabienne ULg; Salmon, Eric ULg

in Revue Médicale de Liège (2014), 69(5-6), 265-269

Des troubles cognitifs touchant principalement le fonctionnement exécutif et mnésique sont observés lors du vieillissement normal et de la maladie d’Alzheimer, et sont associés à des changements au niveau ... [more ▼]

Des troubles cognitifs touchant principalement le fonctionnement exécutif et mnésique sont observés lors du vieillissement normal et de la maladie d’Alzheimer, et sont associés à des changements au niveau de l’activité cérébrale. Il apparait toutefois que différents facteurs sont susceptibles de retarder la survenue des troubles cognitifs, tels que la stimulation mentale ou la pratique d’une activité physique. De même, les prises en charge cognitives permettent d’améliorer le fonctionnement au quotidien des patients présentant une maladie d’Alzheimer (MA). Identifier les facteurs et techniques qui contribuent à maintenir une vitalité cognitive et/ou à contrer les effets de la MA permettront d’optimiser la qualité de vie des seniors. [less ▲]

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See detailEffectiveness of PHARMAceutical care for patients with COPD (PHARMACOP): a randomized controlled trial
Tommelein, Eline; Mehuys, Els; Van Hees, Thierry ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 756-766

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary ... [more ▼]

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary Disease (COPD) have been conducted. We assessed the effectiveness of a pharmaceutical care program for patients with COPD. METHODS: The PHARMACOP-trial is a single-blind 3-month RCT, conducted in 170 community pharmacies in Belgium, enrolling patients prescribed daily COPD medication, aged >/=50 years, and with a smoking history >/=10 pack-years. A computer-generated randomization sequence allocated patients to intervention (n=371), receiving protocol-defined pharmacist care, or control group (n=363), receiving usual pharmacist care (1:1 ratio, stratified by center). Interventions, focusing on inhalation technique and adherence to maintenance therapy, were carried out at start of the trial and at one month follow-up. Primary outcomes were inhalation technique and medication adherence. Secondary outcomes were exacerbation rate, dyspnea, COPD specific and generic health status and smoking behavior. RESULTS: From December 2010 to April 2011, 734 patients were enrolled. 42 patients (5.7%) were lost to follow-up. At the end of the trial, inhalation score (Mean estimated difference [Delta],13.5%; 95% Confidence Interval [CI], 10.8-16.1; P<.0001) and medication adherence (Delta, 8.51%; 95%CI, 4.63-12.4; P<.0001) were significantly higher in the intervention group compared to the control group. In the intervention group, a significantly lower hospitalization rate was observed (9 vs 35; Rate Ratio, 0.28; 95%CI, 0.12-0.64; P=.003). No other significant between-group differences were observed. CONCLUSION: Pragmatic pharmacist care programs improve the pharmacotherapeutic regime in patients with COPD and could reduce hospitalization rates. [less ▲]

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See detailCorrection of vitamin D insufficiency with combined strontium ranelate and vitamin D3 in osteoporotic patients.
Rizzoli, R.; Dawson-Hughes, B.; Kaufman, J.-M. et al

in European Journal of Endocrinology (2014), 170(3), 441-50

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D ... [more ▼]

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D insufficiency in osteoporosis. DESIGN: A 6-month international, randomized, double-blind, parallel-group, phase 3 study. METHODS: A total of 518 men and postmenopausal women aged >/=50 years with primary osteoporosis (T-score </=-2.5 s.d.) and serum 25-hydroxyvitamin D (25(OH)D) >22.5 nmol/l were included. Patients were allocated to strontium ranelate 2 g/vitamin D3 1000 IU daily (n=413) or strontium ranelate 2 g daily (n=105). The participants received calcium 1 g daily. The primary endpoint was serum 25(OH)D at last post-baseline evaluation during 3 months. RESULTS: Both groups were comparable at baseline. Mean baseline of 25(OH)D was 44.1+/-14.6 nmol/l. After 3 months, the percentage of patients with 25(OH)D >/=50 nmol/l was higher with strontium ranelate/vitamin D3 vs strontium ranelate (84 vs 44%, P<0.001; adjusted between-group odds ratio=6.7; 95% CI, 4.2-10.9). The efficacy of the fixed-dose combination on 25(OH)D was maintained at 6 months (86 vs 40%, P<0.001). Mean 25(OH)D was 65.1 and 49.5 nmol/l, respectively, after 3 months and 66.9 and 45.4 nmol/l after 6 months. Physical performance improved in both groups. Falls were 17 and 20% in the strontium ranelate/vitamin D3 and strontium ranelate groups respectively. Parathyroid hormone levels were inversely correlated with 25(OH)D. No clinically relevant differences in safety were observed. CONCLUSIONS: This study confirms the efficacy and safety of fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU for correction of vitamin D insufficiency in osteoporotic patients. [less ▲]

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See detailSimultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry
Dewalque, Lucas ULg; PIRARD, Catherine ULg; DUBOIS, Nathalie ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2014), 949-950

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to ... [more ▼]

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to some hormonal diseases. Numerous large-scale biomonitoring studies have detected the biomarkers of these compounds in more than 75% of the general population. To assess the exposure to these chemicals, we developed an analytical method based on a Solid Phase Extraction (SPE) prior to ultra high pressure liquid chromatographytandem mass spectrometry (UPLC-MS/MS) for the simultaneous measurement of seven phthalate metabolites (monobenzyl phthalate, mono-n-butyl phthalate, mono-iso-butyl phthalate, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2- ethyl-5-oxohexyl phthalate, monoethyl phthalate), four parabens (methyl paraben, ethyl paraben, n-propyl paraben, n-butyl parabens) and benzophenone-3 in human urine. The distinction between unconjugated, glucuro- and sulfoconjugated forms was achieved using different enzymatic hydrolyses. The whole procedure was validated according to the total error approach, and was demonstrated to be linear (regression coefficient ranging from 0.987 to 0.998) and accurate (inter and intra assay precision <17.71%, relative bias <5.87%) in the dosing range of concentrations. The limits of quantification (LOQs) obtained ranged between 0.30 and 1.23 ng/ml depending on the analyte. The reliability of the method was proven in passing successfully the German External Quality Assessment Scheme (G-EQUAS). Moreover, the urine from 25 volunteers were analyzed for the determination of glucuro-, sulfo- and free species separately. Phthalate metabolites, parabens and benzophenone-3 were positively detected in almost all urine samples, with detection rates ranging from 40 to 100%. Levels measured ranged from <LOQ to 2207 ng/ml varying widely depending on the compound and the individual. In our small participating population, most of the phthalate metabolites were excreted predominately as glucuroconjugated forms while parabens and benzophenone-3 were detected as glucuro- and sulfoconjugated species in variable proportions according to the target compound. [less ▲]

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See detailPlant defense stimulation by natural isolates of Bacillus depends on efficient surfactin production
Cawoy, Hélène ULg; Mariutto, Martin; Henry, Guillaume et al

in Molecular Plant-Microbe Interactions [=MPMI] (2014), 27

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See detailMapping French terms in a Belgian guideline on heart failure to international classifications and nomenclatures: the devil is in the detail.
Jamoulle, Marc ULg; Cardillo, Elena; Roumier, Joseph et al

in Informatics in Primary Care (2014), accepted

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies ... [more ▼]

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies more stringent demands on the quality of data-entry at the point-of-care. Non-native English speaking general practitioners experience difficulties in interacting with international classification systems and nomenclatures to facilitate the secondary use of their data and to ensure semantic interoperability. Aim: To identify words and phrases pertaining to the heart failure domain and to explore the difficulties in mapping to corresponding concepts in ICPC-2, ICD-10, SNOMED-CT, and UMLS. Methods: The medical concepts in a Belgian guideline for General Practitioners (GPs) in its French version were extracted manually and coded first in ICPC-2, then ICD-10 by a physician, an expert in classification systems. In addition, mappings were sought with SNOMED-CT and UMLS concepts, using the UMLS SNOMED-CT browser. Results: We retained 143 words and phrases, of which 128 referred to a single concept (1-to-1 mapping), while 15 referred to 2 or more concepts (1-to-n mapping to ICPC rubrics or to the other nomenclatures). In the guideline, words or phrases were often too general for adequate correspondence. Marked discrepancy between semantic tags and types was found. Conclusion: This study illustrates the variability of the various international classifications and nomenclatures, the need for structured guidelines with more attention to precise wording, and the need for classification expertise embedded in sophisticated terminological resources. End-users need support to perform their clinical work in their own language, while still assuring standardized and semantic interoperable medical registration. Collaboration between computational linguists, knowledge engineers, health informaticians and domain experts is needed. [less ▲]

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See detailAnalysis of the global atmospheric methane budget using ECHAM-MOZ simulations for present-day, pre-industrial time and the Last Glacial Maximum
Basu, A.; Schultz, M. G.; Schröder, S. et al

in Atmospheric Chemistry & Physics Discussions (2014), 14

Atmospheric methane concentrations increased considerably from pre-industrial (PI) to present times largely due to anthropogenic emissions. However, firn and ice core records also document a notable rise ... [more ▼]

Atmospheric methane concentrations increased considerably from pre-industrial (PI) to present times largely due to anthropogenic emissions. However, firn and ice core records also document a notable rise of methane levels between the Last Glacial Maximum (LGM) and the pre-industrial era, the exact cause of which is not entirely clear. This study investigates these changes by analyzing the methane sources and sinks at each of these climatic periods. Wetlands are the largest natural source of methane and play a key role in determining methane budget changes in particular in the absence of anthropogenic sources. Here, a simple wetland parameterization suitable for coarse-scale climate simulations over long periods is introduced, which is derived from a high- resolution map of surface slopes together with various soil hydrology parameters from the CARAIB vegetation model. This parameterization was implemented in the chem- istry general circulation model ECHAM5-MOZ and multi-year time slices were run for LGM, PI and present-day (PD) climate conditions. Global wetland emissions from our parameterization are 72 Tg yr [less ▲]

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See detailL’intérêt de la spectroscopie proche infrarouge en analyse de terre (synthèse bibliographique)
Genot, Valérie ULg; Bock, Laurent ULg; Dardenne, Pierre et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2),

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See detailPotentiality of clay raw materials from northern Morocco in ceramic industry: Tetouan and Meknes areas
El Ouahabi, Meriam ULg; Daoudi, Lahcen; De Vleeschouwer, François et al

in Journal of Minerals and Materials Characterization and Engineering (2014)

This study aims at evaluating the potential suitability of Tetouan and Meknes (central Morocco) clay material as raw materials in various ceramic applications by investigating their textural, chemical ... [more ▼]

This study aims at evaluating the potential suitability of Tetouan and Meknes (central Morocco) clay material as raw materials in various ceramic applications by investigating their textural, chemical, thermal and firing characteristics. Textural properties were identified by specific surface area, cation exchange capacity (CEC) and bulk density (ρs). Chemical and thermal properties were assessed using XRF and TG/DTA techniques, respectively. Firing characteristics at temperatures from 800°C to 1100°C were determined by linear firing shrinkage, loss on weight and water absorption capacity. The Meknes clays are characterised by medium cation exchange capacity (CEC) and specific surface area (SSA) values due to their moderate smectite content. The Tetouan clays have medium to low CEC and medium SSA values. The main oxides in the clayey samples are SiO2 (35 – 54.3 wt.%), Al2O3 (20.6 – 43.9 wt.%), and Fe2O3 (9.7 – 22.4 wt.%). The amount of CaO in Meknes clays ranges from 8 to 12 wt.%, whereas CaO is only present in some Tetouan clay (TE4, TE7, TN4 and TN5). A significant densification of ceramic behaviour could be noticed for most of Tetouan clays at firing temperatures above 1000°C. Meknes clays show earlier densification from 800 °C. The chemical, textural and ceramic properties of Tetouan and Meknes clays indicate their suitability as raw materials for the production of structural ceramics. The high amount of Fe2O3 in all clays makes them inappropriate in fine ceramics. [less ▲]

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See detailAsymmetric facial skin viscoelasticity during climacteric aging.
Pierard, Gérald ULg; Hermanns-Le, Trinh; Gaspard, Ulysse ULg et al

in Clinical, cosmetic and investigational dermatology (2014), 7

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the ... [more ▼]

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the aging process. METHODS: Skin viscoelasticity was compared on both cheeks in premenopausal and post-menopausal women with indoor occupational activities somewhat limiting the influence of chronic sun exposure. Eighty-four healthy women comprising 36 premenopausal women and 48 early post-menopausal women off hormone replacement therapy were enrolled in two groups. The tensile characteristics of both cheeks were tested and compared in each group. A computerized suction device equipped with a 2 mm diameter hollow probe was used to derive viscoelasticity parameters during a five-cycle procedure of 2 seconds each. Skin unfolding, intrinsic distensibility, biological elasticity, and creep extension were measured. RESULTS: Both biological elasticity and creep extension were asymmetric on the cheeks of the post-menopausal women. In contrast, these differences were more discrete in the premenopausal women. CONCLUSION: Facial skin viscoelasticity appeared to be asymmetric following menopause. The possibility of asymmetry should be taken into account in future studies of the effects of hormone replacement therapy and any antiaging procedure on the face in menopausal women. [less ▲]

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See detailImportance of concomitant local and systemic eosinophilia in uncontrolled asthma.
SCHLEICH, FLorence ULg; Chevremont, Anne; Paulus, Virginie et al

in The European respiratory journal (2014), 44

Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic eosinophilia. In this study, we sought to determine the ... [more ▼]

Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic eosinophilia. In this study, we sought to determine the prevalence and characteristics of patients with concordant and discordant systemic and bronchial eosinophilia.We conducted a retrospective study on 508 asthmatics with successful sputum induction. We assessed the relationship between blood and sputum eosinophils by breaking down the population into four groups according to blood (>/=400 cells per mm3) and sputum (>/=3%) eosinophils. Then, we prospectively reassessed the link between eosinophils and asthma control (Asthma Control Questionnaire (ACQ)) and exacerbation rate in a new cohort of 250 matched asthmatics.In our retrospective cohort, asthmatics without eosinophilic inflammation were the largest group (49%). The group with isolated sputum eosinophilia (25%) was, compared with noneosinophilic asthma, associated with lower forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity ratio and higher bronchial hyperresponsiveness and exhaled nitric oxide fraction (FeNO). Asthmatics exhibiting isolated systemic eosinophilia (7%) had similar characteristics as noneosinophilic asthmatics. The group with concordant systemic and airway eosinophilia (19%) showed remarkable male predominance, and had the lowest airway calibre, ACQ score and quality of life, and the highest bronchial hyperresponsiveness, FeNO and exacerbation rate. The prospective cohort confirmed the different subgroup proportions and the higher ACQ and exacerbation rates in cases of diffuse eosinophilia compared with noneosinophilic asthmatics.Concomitant systemic and bronchial eosinophilic inflammation contribute to poor asthma control. [less ▲]

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See detailLearning from our European imaging colleagues.
Weissman, Neil J.; Lancellotti, Patrizio ULg

in JACC. Cardiovascular imaging (2014), 7(6), 639-40

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See detailSkin viscoelasticity in incipient gravitational syndrome.
Pierard, Gérald ULg; Paquet, Philippe; Pierard-Franchimont, Claudine ULg

in Journal of cosmetic dermatology (2014), 13(1), 52-5

BACKGROUND: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are ... [more ▼]

BACKGROUND: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are altered. AIMS: To assess incipient gravitational edema due to chronic venous insufficiency using measurements of the skin tensile strength. METHOD: A total of 21 women aged 28-37 years were enrolled in the study. Evaluations were made twice in each subject following an alternate use and avoidance of daytime elastic contention. Skin viscoelasticity was measured on the mid portion of the calves using a computerized suction device. RESULTS: The discretely increased consistency of skin showing abnormal rheological characteristics at the site of incipient gravitational edema was significantly improved by contention therapy. Under progressive suction measurements, both skin distensibility, biologic elasticity and hysteresis were increased after wearing tight stockings. The biologic elasticity appears to be the most sensitive parameter pointing to the diagnosis of gravitational syndrome. CONCLUSION: Noninvasive measurements of the skin viscoelasticity, particularly the biologic elasticity, represent an objective assessment of both early gravitational edema and its control by contention therapy. [less ▲]

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See detailAn asymptotic expansion-based method for a spectral approach in equivalent statistical linearization
Canor, Thomas ULg; Blaise, Nicolas ULg; Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2014)

Equivalent linearization consists in replacing a nonlinear system with an equivalent linear one whose parameters are tuned with regard to the minimization of a suitable function. In particular, the ... [more ▼]

Equivalent linearization consists in replacing a nonlinear system with an equivalent linear one whose parameters are tuned with regard to the minimization of a suitable function. In particular, the Gaussian equivalent linearization expresses the properties of an equivalent linear system in terms of the mean vector and the covariance matrix of the responses, which are the unknowns of the optimization problem in a spectral approach. Even though the system has been linearized, the resulting set of equations is nonlinear. The computational effort in this method pertains to the solution of a possibly large set of nonlinear algebraic equations involving integrals and inversions of full matrices. This work proposes to develop and apply an asymptotic expansion-based method to facilitate and to improve the statistical linearization for large nonlinear structures. The proposed developments demonstrate that for slightly to moderately coupled nonlinear systems, the equivalent linearization can be applied with an appropriate modal approach and eventually seen as a convergent series initiated with the stochastic response of a main decoupled linear system. With this method, the computational effort is attractively reduced, the conditioning of the set of nonlinear algebraic equations is improved and inversion of full transfer matrices and repeated integrations are avoided. The paper gives a formal description of the method and illustrates its implementation and performances with the computation of stationary responses of nonlinear structures subject to coherent random excitation fields. [less ▲]

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See detailA Monitoring Campaign for Luhman 16AB. I. Detection of Resolved Near-Infrared Spectroscopic Variability
Burgasser, A. J.; Gillon, Michaël ULg; Faherty, J. K. et al

in Astrophysical Journal (2014), 785

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See detailPractice of enteral nutrition in very low birth weight and extremely low birth weight infants
SENTERRE, Thibault ULg

in World Review of Nutrition and Dietetics (2014), 110

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See detailcomment j'explore les infections nosocomiales en néonatologie
Dachy, Angélique ULg; Battisti, Oreste ULg

in Revue Médicale de Liège (2014)

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See detailAttaques massives de simulies et mort brutale
Caron, Yannick ULg; Losson, Bertrand ULg

in Veterinaria (Bruxelles) : Bulletin d’Information de l’Union Syndicale Vétérinaire Belge (2014)

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See detailSHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Elong Edimo, W; Schurmans, Stéphane ULg; Roger, PP et al

in Advances in Biological Regulation (2014), 54

Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of PI(3,4,5)P3, PI(4,5)P2 and PI(3,5)P2. The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to ... [more ▼]

Phosphoinositide 5-phosphatases are critical enzymes in modulating the concentrations of PI(3,4,5)P3, PI(4,5)P2 and PI(3,5)P2. The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2. Data obtained in zebrafish and in mice have shown that SHIP2 is critical in development and growth. Exome sequencing identifies mutations in the coding region of SHIP2 as a cause of opsismodysplasia, a severe but rare chondrodysplasia in human. SHIP2 has been reported to have both protumorigenic and tumor suppressor function in human cancer very much depending on the cell model. This could be linked to the relative importance of PI(3,4)P2 (a product of SHIP2 phosphatase activity) which is also controlled by the PI 4-phosphatase and tumor suppressor INPP4B. In the glioblastoma cell line 1321 N1, that do not express PTEN, lowering SHIP2 expression has an impact on the levels of PI(3,4,5)P3, cell morphology and cell proliferation. It positively stimulates cell proliferation by decreasing the expression of key regulatory proteins of the cell cycle such as p27. Together the data point out to a role of SHIP2 in development in normal cells and at least in cell proliferation in some cancer derived cells. [less ▲]

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See detailCurrent systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system
Ciais, P.; Dolman, A. J.; Bombelli, A. et al

in Biogeosciences (2014), 11(13), 3547--3602

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify ... [more ▼]

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires transformational advances from the existing sparse, exploratory framework towards a dense, robust, and sustained system in all components: anthropogenic emissions, the atmosphere, the ocean, and the terrestrial biosphere. The paper is addressed to scientists, policymakers, and funding agencies who need to have a global picture of the current state of the (diverse) carbon observations.We identify the current state of carbon observations, and the needs and notional requirements for a global integrated carbon observation system that can be built in the next decade. A key conclusion is the substantial expansion of the ground-based observation networks required to reach the high spatial resolution for CO2 and CH4 fluxes, and for carbon stocks for addressing policy-relevant objectives, and attributing flux changes to underlying processes in each region. In order to establish flux and stock diagnostics over areas such as the southern oceans, tropical forests, and the Arctic, in situ observations will have to be complemented with remote-sensing measurements. Remote sensing offers the advantage of dense spatial coverage and frequent revisit. A key challenge is to bring remote-sensing measurements to a level of long-term consistency and accuracy so that they can be efficiently combined in models to reduce uncertainties, in synergy with groundbased data. Bringing tight observational constraints on fossil fuel and land use change emissions will be the biggest challenge for deployment of a policy-relevant integrated carbon observation system. This will require in situ and remotely sensed data at much higher resolution and density than currently achieved for natural fluxes, although over a small land area (cities, industrial sites, power plants), as well as the inclusion of fossil fuel CO2 proxy measurements such as radiocarbon in CO2 and carbon-fuel combustion tracers. Additionally, a policy-relevant carbon monitoring system should also provide mechanisms for reconciling regional top-down (atmosphere-based) and bottom-up (surface-based) flux estimates across the range of spatial and temporal scales relevant to mitigation policies. In addition, uncertainties for each observation data-stream should be assessed. The success of the system will rely on long-term commitments to monitoring, on improved international collaboration to fill gaps in the current observations, on sustained efforts to improve access to the different data streams and make databases interoperable, and on the calibration of each component of the system to agreed-upon international scales. [less ▲]

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See detailEverolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial.
Andre, Fabrice; O'Regan, Ruth; Ozguroglu, Mustafa et al

in The lancet oncology (2014)

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to ... [more ▼]

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited women with HER2-positive, trastuzumab-resistant, advanced breast carcinoma who had previously received taxane therapy. Eligible patients were randomly assigned (1:1) using a central patient screening and randomisation system to daily everolimus (5 mg/day) plus weekly trastuzumab (2 mg/kg) and vinorelbine (25 mg/m2) or to placebo plus trastuzumab plus vinorelbine, in 3-week cycles, stratified by previous lapatinib use. The primary endpoint was progression-free survival (PFS) by local assessment in the intention-to-treat population. We report the final analysis for PFS; overall survival follow-up is still in progress. This trial is registered with ClinicalTrials.gov, number NCT01007942. FINDINGS: Between Oct 26, 2009, and May 23, 2012, 569 patients were randomly assigned to everolimus (n=284) or placebo (n=285). Median follow-up at the time of analysis was 20.2 months (IQR 15.0-27.1). Median PFS was 7.00 months (95% CI 6.74-8.18) with everolimus and 5.78 months (5.49-6.90) with placebo (hazard ratio 0.78 [95% CI 0.65-0.95]; p=0.0067). The most common grade 3-4 adverse events were neutropenia (204 [73%] of 280 patients in the everolimus group vs 175 [62%] of 282 patients in the placebo group), leucopenia (106 [38%] vs 82 [29%]), anaemia (53 [19%] vs 17 [6%]), febrile neutropenia (44 [16%] vs ten [4%]), stomatitis (37 [13%] vs four [1%]), and fatigue (34 [12%] vs 11 [4%]). Serious adverse events were reported in 117 (42%) patients in the everolimus group and 55 (20%) in the placebo group; two on-treatment deaths due to adverse events occurred in each group. INTERPRETATION: The addition of everolimus to trastuzumab plus vinorelbine significantly prolongs PFS in patients with trastuzumab-resistant and taxane-pretreated, HER2-positive, advanced breast cancer. The clinical benefit should be considered in the context of the adverse event profile in this population. FUNDING: Novartis Pharmaceuticals Corporation. [less ▲]

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See detailL'âgisme et ses conséquences cliniques en oncogériatrie: état des lieux et pistes d'interventions
Schroyen, Sarah ULg; Adam, Stéphane ULg; Jerusalem, Guy ULg et al

in Revue Médicale de Liège (2014), 69(5-6), 395-401

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See detailBuilding a validation measure for activity-based transportation models based on mobile phone data
Liu, Feng; Janssens, Davy; Cui, JianXun et al

in Expert Systems with Applications (2014), 41(14), 6174-6189

Activity-based micro-simulation transportation models typically predict 24-h activity-travel sequences for each individual in a study area. These sequences serve as a key input for travel demand analysis ... [more ▼]

Activity-based micro-simulation transportation models typically predict 24-h activity-travel sequences for each individual in a study area. These sequences serve as a key input for travel demand analysis and forecasting in the region. However, despite their importance, the lack of a reliable benchmark to evaluate the generated sequences has hampered further development and application of the models. With the wide deployment of mobile phone devices today, we explore the possibility of using the travel behavioral information derived from mobile phone data to build such a validation measure. Our investigation consists of three steps. First, the daily trajectory of locations, where a user performed activities, is constructed from the mobile phone records. To account for the discrepancy between the stops revealed by the call data and the real location traces that the user has made, the daily trajectories are then transformed into actual travel sequences. Finally, all the derived sequences are classified into typical activity-travel patterns which, in combination with their relative frequencies, define an activity-travel profile. The established profile characterizes the current activity-travel behavior in the study area, and can thus be used as a benchmark for the assessment of the activity-based transportation models. By comparing the activity-travel profiles derived from the call data with statistics that stem from traditional activity-travel surveys, the validation potential is demonstrated. In addition, a sensitivity analysis is carried out to assess how the results are affected by the different parameter settings defined in the profiling process. [less ▲]

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See detailLong-Term Care Insurance and Family
Pestieau, Pierre ULg; Canta, Chiara

in B.E. Journal of Economic Analysis & Policy (2014)

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See detailValidity and Reliability of the French version of the STarT Back Screening Tool for patients with low back pain.
Bruyère, Olivier ULg; Demoulin, Maryline; Beaudart, Charlotte ULg et al

in Spine (2014), 39(2), 123-128

Study Design. Observational prospective study.Objective. Our objective was to assess the reliability and validity of the French version of the Keele STarT Back Screening Tool (SBST).Summary of Background ... [more ▼]

Study Design. Observational prospective study.Objective. Our objective was to assess the reliability and validity of the French version of the Keele STarT Back Screening Tool (SBST).Summary of Background Data. The SBST is a recently validated tool developed to identify subgroups of patients with low back pain (LBP) to guide early secondary prevention in primary care.Methods. Outpatients with LBP aged 18 years or more, attending a rehabilitation centre, a back school, a private physiotherapy unit or a fitness centre were included. Patients were assessed through the SBST, Roland-Morris Disability Questionnaire (RMDQ), Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ), Medical Outcomes Survey Short Form 36 (SF-36) questionnaire, and a pain visual analogic scale (VAS). Test-retest reliability was assessed with Kappa score or the intraclass correlation coefficient (ICC), internal consistency of the psychological subscale with the Cronbach alpha coefficient, construct validity with the Spearman's correlation coefficient, and floor and ceiling effects by percentage frequency of lowest or highest possible score achieved by respondents.Results. 108 patients with LBP were included. The test-retest reliability of the SBST total score was excellent with an ICC of 0.90 (0.81-0.95). The Cronbach alpha coefficient was 0.73 showing a good internal consistency for the psychological subscale. High Spearman's correlation coefficients of 0.74 between SBST and RMDQ, and 0.74 between the SBST and OMPSQ were observed. As expected, low to moderate correlations were observed between the SBST total score and some dissimilar measures of the SF-36. The lowest possible SBST score was observed for 8 patients (7.4%) whereas only three patients (2.8%) had the highest possible SBST score.Conclusion. The French version of the SBST is a reliable and valid questionnaire consistent with the original English version. Therefore, this new version may help French-speaking clinicians and scientists to stratify patients with LBP. [less ▲]

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See detailEuropean multicentre validation study of the accuracy of E/e' ratio in estimating invasive left ventricular filling pressure: EURO-FILLING study.
Galderisi, Maurizio; Lancellotti, Patrizio ULg; Donal, Erwan et al

in European Heart Journal - Cardiovascular Imaging (2014)

AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for ... [more ▼]

AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for calculating the ratio between the preload-dependent transmitral E velocity and the average of septal and lateral early diastolic velocities (e') of the mitral annulus. Despite its wide use, real utility of the E/e' ratio has been recently challenged in patients with either very advanced heart failure or preserved left ventricular (LV) ejection fraction. However, only few studies performed the invasive and non-invasive estimation of LVFP simultaneously. The EURO-FILLING Study will validate the E/e' ratio (and additional non-invasive estimates) against simultaneously measured LVFP obtained by left heart catheterization in a multicentre study involving reference European echo laboratories collecting a wide population sample size of cardiac patients with and without heart failure. METHODS AND RESULTS: The EURO-FILLING study is a large, prospective observational study in which simultaneous assessment of invasive and non-invasive measurements of LVFP will be acquired in eight reference European centres. Centralized reading of the collected parameters will be performed in a core laboratory. Not only standardized echo Doppler measurements but also novel echo parameters such as LV global longitudinal strain and global atrial strain (obtainable by two-dimensional speckle tracking echocardiography) will be tested for predicting invasive measurements of LVFP. CONCLUSIONS: The EURO-FILLING study is expected to provide important information on non-invasive assessment of LVFP and to contribute to the standardization of this assessment in clinical practice. [less ▲]

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See detailA new Lower Cretaceous ichthyosaur from Russia reveals skull shape conservatism within Ophthalmosaurinae
Fischer, Valentin ULg; Arkhangelsky, Maxim; Uspensky, Gleb et al

in Geological Magazine (2014), 151(1), 60-70

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late ... [more ▼]

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late Jurassic ophthalmosaurine Ophthalmosaurus is often regarded as a hyperspecialized deep diver, very little is known about the anatomy, evolutionary history, and ecology of Cretaceous ophthalmosaurines because of the scarcity of the fossils and the lack of well-preserved skull material. Here, we describe the skull of a new basal ophthalmosaurine ichthyosaur, Leninia stellans gen. et sp. nov., from the lower Aptian of western Russia, and compare the ocular characteristics of ophthalmosaurids. Leninia is recovered as a basal ophthalmosaurine; it possesses unique traits such as star-shaped frontal–parietal sutures as well as features previously thought to be unique to Ophthalmosaurus such as a supratemporal–stapes contact. A large sclerotic aperture – significantly bigger than in platypterygiine ophthalmosaurids and similar to that of the largest-eyed modern animals (giant and colossal squids) – and reduced dentition appear widespread within ophthalmosaurines. This conservatism suggests ophthalmosaurine ophthalmosaurids occupied similar ecological niche(s) throughout their long evolutionary history. [less ▲]

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See detailVitamin D status and bone mineral density changes during alendronate treatment in postmenopausal osteoporosis.
Roux, Christian; Binkley, Neil; Boonen, Steven et al

in Calcified tissue international (2014), 94(2), 153-7

Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed ... [more ▼]

Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by 6 months and increasing spine and hip bone mineral density (BMD) after 1 year than SC. This post hoc analysis examined the relationship between BMD gain and 25(OH)D in women in SC receiving alendronate (SC/ALN, n = 134, 52% of the SC group) and in the ALN/D group (n = 257). At baseline, participants were of mean age 73 years and 72% were Caucasian, with a mean 25(OH)D of 14.9 ng/mL. In the SC/ALN group, most received vitamin D, although intake of vitamin D varied extensively (51% received <400 mug/day). In this group, end-of-study 25(OH)D correlated positively with mean percent increases from baseline in lumbar spine and femoral neck BMD [Pearson correlation coefficients (95% CI) = 0.23 (0.02-0.41) and 0.24 (0.03-0.41), respectively]. Baseline 25(OH)D correlated with increases in only lumbar spine BMD [Pearson correlation coefficient (95% CI) = 0.22 (0.01-0.40)]. No correlations between mean BMD change and 25(OH)D were seen with ALN/D. In conclusion, in postmenopausal women with osteoporosis and low 25(OH)D receiving alendronate and a wide range of vitamin D doses, the increase in lumbar spine and femoral neck BMD was positively correlated with serum 25(OH)D achieved by the end of the study and, to some extent, with 25(OH)D concentrations at baseline. The degree of success of alendronate therapy for osteoporosis may depend on the vitamin D status of patients. [less ▲]

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See detailLE DÉFI DU CONTRÔLE LOCAL DANS LE CANCER PULMONAIRE NON A PETITES CELLULES, LOCALEMENT AVANCE, NON OPERABLE
BARTHELEMY, Nicole ULg; LENNERTS, Evelyne ULg; MEYNS, Mia ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 75-80

Le cancer broncho-pulmonaire non à petites cellules (CBNPC) est fréquent. Pour près d’un patient sur cinq, au moment du diagnostic, la maladie est déjà localement avancée et inopérable. A ce stade, le ... [more ▼]

Le cancer broncho-pulmonaire non à petites cellules (CBNPC) est fréquent. Pour près d’un patient sur cinq, au moment du diagnostic, la maladie est déjà localement avancée et inopérable. A ce stade, le pronostic de cette affection est mauvais, caractérisé, entre autres, par un taux élevé de réci - dive locale, malgré la chimiothérapie et la radiothérapie. Le but de cette revue est de décrire l’hétérogénéité de ce groupe de patients, de clarifier les modalités de traitement combinant la chimiothérapie et la radiothérapie et de préciser l’intérêt des techniques modernes de radiothérapie pour améliorer le contrôle local [less ▲]

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See detailLA RADIOTHÉRAPIE DANS LE CANCER DU RECTUM CHEZ LA PERSONNE ÂGÉE: Quel bénéfice pour le traitement ?
MARTINIVE, Philippe ULg; ALLEPAERTS, Sophie ULg; VAN DAELE, Daniel ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 47-52

Dans les années à venir, nous serons de plus en plus amenés à prendre en charge des patients âgés en oncologie. Dans ce contexte, quelles sont les évidences scientifiques à notre disposition qui nous ... [more ▼]

Dans les années à venir, nous serons de plus en plus amenés à prendre en charge des patients âgés en oncologie. Dans ce contexte, quelles sont les évidences scientifiques à notre disposition qui nous permettent de prendre en charge de façon correcte cette population oncologique âgée ? Les patients âgés présentent souvent de multiples co-morbidités pouvant interférer avec le traitement oncologique rendant d’autant plus complexe leur prise en charge. Le pic d’inci - dence du cancer du rectum se situe autour des 80 ans, loin au-dessus de l’âge moyen des patients inclus dans les études cliniques. La survie globale des patients traités pour un cancer du rectum s’est améliorée au cours de la dernière décennie, essentiellement pour des patients de moins de 75 ans. Le trai - tement du cancer du rectum nécessite une approche multidis - ciplinaire. L’évaluation gériatrique en fait partie intégrante. Elle permet de définir au mieux la stratégie thérapeutique en fonction de l’état général du patient, de son contexte neuro- psychologique, fonctionnel et social. La radiothérapie joue un rôle majeur dans le traitement du rectum. Quelle est sa place chez les personnes âgées ? Bénéficient-elles également de la radiothérapie, comme la population jeune sélectionnée dans les études contrôlées ? Quel est l’impact de ce traitement sur la qualité de vie ? Voilà des questions essentielles auxquelles nous allons tenter d’apporter une réponse [less ▲]

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See detailMicro-Computed Tomography Based Computational Fluid Dynamics for the Determination of Shear Stresses in Scaffolds Within a Perfusion Bioreactor
Zermatten, Emilie; Vetsch, Jolanda Rita; Ruffoni, Davide ULg et al

in ANNALS OF BIOMEDICAL ENGINEERING (2014), 42(5), 1085-1094

Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous ... [more ▼]

Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk fibroin (SF) scaffold with an irregular network of interconnected pores. Their complex 3D geometries are imaged by micro-computed tomography and used in direct pore-level simulations of the entire scaffold-bioreactor system to numerically solve the governing mass and momentum conservation equations for fluid flow through porous media. The velocity field and wall shear stress distribution are determined for both scaffolds. The PCL scaffold exhibited an asymmetric distribution with peak and plateau, while the SF scaffold exhibited a homogenous distribution and conditioned the flow more efficiently than the PCL scaffold. The methodology guides the design and optimization of the scaffold geometry. [less ▲]

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See detailThe retirement of the migrant labor force: pension portability and beyond
Jousten, Alain ULg

in CESifo Economic Studies (2014)

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – ... [more ▼]

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – system sustainability or distributive characteristics. The present paper provides a fresh look at the nexus between these two literatures. It discusses the impact of the European social security coordination mechanisms on individual decision-making and on the functioning of social security systems – with a focus on retirement. The paper argues that such effects are non-negligible and are likely to have major policy consequences. [less ▲]

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See detailDeconsecrating a doctrinal monument: Raymond M. Lemaire and the revisions of the Venice Charter
Houbart, Claudine ULg

in Change Over Time (2014), (fall),

Considering himself as the “main author” of the charter, Raymond M. Lemaire has been one of the first, together with Piero Gazzola, to plead for a revision of the document. As early as 1971, the two men ... [more ▼]

Considering himself as the “main author” of the charter, Raymond M. Lemaire has been one of the first, together with Piero Gazzola, to plead for a revision of the document. As early as 1971, the two men, respectively first Secretary General and President of ICOMOS, tended to launch a debate in favour of a better consideration of the social value of heritage, and the development of specific principles for historical cities conservation, to be included in the Venice charter. Lemaire’s recent experience in that field had indeed convinced him that, contrary to the assertion of article 14, “a literal application of principles valid for monuments, considered as such, is not always possible, nor desirable, for the ensembles”. The adoption of the Amsterdam declaration didn’t put an end to his efforts. Despite his unsuccessful attempt to get a revised version approved by the ICOMOS General assembly in Moscow (1978), R.M.Lemaire always remained critical towards the charter and the application of its principles in the field, underlining, in the eighties, its shortcomings in terms of cultural diversity and, in one of his last texts, in 1996, the negative effect of article 9, leading to the idea that “the mere essence of a conservation operation is a modernist intervention on the edifice or neighbourhood”. Beyond its interest for conservation history, the awareness of Lemaire’s early critical position towards the Venice Charter should inspire the current debates and help us overcome our reluctance to challenge the sacred principles of what we consider a doctrinal monument. [less ▲]

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See detailCreativity and entrepreneurship: Changing currents in education and public-life
Dufays, Frédéric ULg

in International Journal of Entrepreneurial Behaviour and Research (2014), 20(3), 297-299

Looking at how to foster creativity and innovation for economic and social value, Lynn Book and David Phillips suggest bridging arts and sciences both within the academy and with external partners as a ... [more ▼]

Looking at how to foster creativity and innovation for economic and social value, Lynn Book and David Phillips suggest bridging arts and sciences both within the academy and with external partners as a key element. In this book, they compile a series of contributions that analyse, share experiences, model such (cross-sector) partnerships. [less ▲]

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See detailPlatelet reactivity and cardiovascular events after percutaneous coronary intervention in patients with stable coronary artery disease: the Stent Thrombosis In Belgium (STIB) trial
LEGRAND, Victor ULg; CUISSET, T; CHENU, P et al

in EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2014), 10

PR measured before PCI in stable patients undergoing elective PCI who are preloaded with 500 mg of aspirin and 600 mg of clopidogrel is not predictive of periprocedural myocardial injury or adverse ... [more ▼]

PR measured before PCI in stable patients undergoing elective PCI who are preloaded with 500 mg of aspirin and 600 mg of clopidogrel is not predictive of periprocedural myocardial injury or adverse ischaemic complications up to 30 days. [less ▲]

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See detailDeterminants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.
Voilliot, Damien; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014)

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the ... [more ▼]

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. METHODS AND RESULTS: We prospectively enrolled 63 patients with SSc (age 54+/-3years, 76% female) followed in CHU Sart-Tilman in Liege. All patients underwent graded semi-supine exercise echocardiography. Systolic pulmonary arterial pressure (sPAP) was derived from the peak velocity of the tricuspid regurgitation jet and adding the estimation of right atrial pressure, both at rest and during exercise. Resting pulmonary arterial hypertension (PH) was defined as sPAP >35mmHg and EIPH as sPAP >50mmHg during exercise. The following formulas were used: mean PAP (mPAP)=0.61xsPAP+2, left atrial pressure (LAP)=1.9+1.24xleft ventricular (LV) E/e' and pulmonary vascular resistance (PVR)=(mPAP-LAP)/LV cardiac output (CO) and slope of mPAP-LVCO relationship=changes in mPAP/changes in LVCO. Resting PH was present in 3 patients (7%) and 21 patients developed EIPH (47%). Patients with EIPH had higher resting LAP (10.3+/-2.2 versus 8.8+/-2.3mmHg; p=0.03), resting PVR (2.6+/-0.8 vs. 1.4+/-1.1Woods units; p=0.004), exercise LAP (13.3+/-2.3 vs. 9+/-1.7mmHg; p<0.0001), exercise PVR (3.6+/-0.7 vs. 2.1+/-0.9 Woods units; p=0.02) and slope of mPAP-LVCO (5.8+/-2.4 vs. 2.9+/-2.1mmHg/L/min; p<0.0001). After adjustment for age and gender, exercise LAP (beta=3.1+/-0.8; p=0.001) and exercise PVR (beta=7.9+/-1.7; p=0.0001) were independent determinants of exercise sPAP. CONCLUSION: EIPH is frequent in SSc patients and is mainly related to both increased exercise LV filling pressure and exercise PVR. [less ▲]

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See detailUnited but (un)equal: human capital, probability of divorce, and the marriage contract
Cremer, Helmuh; Pestieau, Pierre ULg; Roeder, Kerstin

in Journal of Population Economics (2014)

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See detailMechanical properties of alloy Ti-6Al-4V and of stainless steel 316L processed by Selective Laser Melting: Influence of out-of-equilibrium microstructures
Mertens, Anne ULg; Reginster, Sylvie ULg; Paydas, Hakan ULg et al

in Powder Metallurgy (2014), 57(3), 184-189

Ti-6Al-4V and stainless steel 316L have been processed by selective laser melting under similar conditions, and their microstructures and mechanical behaviours have been compared in details. Under the ... [more ▼]

Ti-6Al-4V and stainless steel 316L have been processed by selective laser melting under similar conditions, and their microstructures and mechanical behaviours have been compared in details. Under the investigated conditions, Ti-6Al-4V exhibits a more complex behaviour than stainless steel 316L with respect to the occurrence of microstructural and mechanical anisotropy. Moreover, Ti-6Al-4V appears more sensitive to the build-up of internal stresses when compared with stainless steel 316L, whereas stainless steel 316L appears more prone to the formation of “lack of melting” defects. This correlates nicely with the difference in thermal conductivity between the two materials. Thermal conductivity was shown to increase strongly with increasing temperature and the thermophysical properties appeared to be influenced by variations in the initial metallurgical state. [less ▲]

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