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See detailLearning from Incidents and Incident Reporting: Safety Governance at a Belgian Nuclear Research Center
Rossignol, Nicolas ULiege; Van Oudheusden, Michiel ULiege

in Science, Technology & Human Values (2017), 42

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews ... [more ▼]

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews and focus groups with personnel, it illustrates how REX enacts a safety governmentality centered on identifying incident causes and culprits. As this governmentality mode obscures the epistemic and political character of incidents, it closes down important opportunities for collective learning about safety and safety governance. It is argued that joint reflection about incidents and resistances towards incident reporting serve as fruitful starting points for a more reflexive safety governance that makes explicit how decisions are made in high-risk contexts. Social scientists can enhance governance of this kind by pointing to different perceptions and evaluations of incidents and by insisting that contending interpretations are confronted and accounted for. [less ▲]

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See detailSartre, le XXe siècle
Cormann, Grégory ULiege

in Médium (2017), 50

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See detailScreening for the metabolic syndrome in subjects with migraine
Streel, Sylvie ULiege; Donneau, Anne-Françoise ULiege; Dardenne, Nadia ULiege et al

in Cephalalgia : An International Journal of Headache (2017)

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See detailReduced intensity and non-myeloablative allogenic stem cell transplantation from alternative HLA-mismatched donors for Hodgkin's lymphoma: a study by the French Society of Bone Marrow Transplantation and Cellular Therapy
Gauthier, J; Castagna, L; Garnier, F et al

in Bone Marrow Transplantation (2017), 52

Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed ... [more ▼]

Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed Hodgkin lymphoma (HL). When an HLA-matched donor is lacking a graft from a familial haploidentical (HAPLO) donor, a mismatched unrelated donor (MMUD) or cord blood (CB) might be considered. In this retrospective study, we compared the outcome of patients with HL undergoing a RIC or NMA allo-SCT from HAPLO, MMUD or CB. Ninety-eight patients were included. Median follow-up was 31 months for the whole cohort. All patients in the HAPLO group (N = 34) received a T-cell replete allo-SCT after a NMA (FLU-CY-TBI, N = 31, 91%) or a RIC (N = 3, 9%) followed by post-transplant cyclophosphamide. After adjustment for significant covariates, MMUD and CB were associated with significantly lower GvHD-free relapse-free survival (GRFS; hazard ratio (HR) = 2.02, P = 0.03 and HR = 2.43, P = 0.009, respectively) compared with HAPLO donors. In conclusion, higher GRFS was observed in Hodgkin lymphoma patients receiving a RIC or NMA allo-SCT with posttransplant cyclophosphamide from HAPLO donors. Our findings suggest they should be favoured over MMUD and CB in this setting. [less ▲]

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See detailOn the finiteness of the weighted likelihood estimator of ability
Magis, David ULiege; Verhelst, Norman

in Psychometrika (2017), 82

The purpose of this note is to focus on the finiteness of the weighted likelihood estimator (WLE) of ability in the context of dichotomous and polytomous item response theory (IRT) models. It is ... [more ▼]

The purpose of this note is to focus on the finiteness of the weighted likelihood estimator (WLE) of ability in the context of dichotomous and polytomous item response theory (IRT) models. It is established that the WLE always returns finite ability estimates. This general result is valid for dichotomous (one-, two-, three- and four-parameter logistic) IRT models, the class of polytomous difference models and divide-by-total models, independently of the number of items, the item parameters and the response patterns. Further implications of this result are outlined. [less ▲]

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See detailTransdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.
Sergeant, Camille; Jublanc, Christel; Leclercq, Delphine et al

in American Journal of Surgical Pathology (2017)

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a ... [more ▼]

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed. [less ▲]

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See detailPratiques phytosanitaires des producteurs de tomates du Burkina Faso et risques pour la santé et l’environnement
Son, Diakalia ULiege; Somda, Irénée; Legrève, Anne et al

in Cahiers Agricultures (2017), 26(2), 6

To assess the phytosanitary practices of tomato growers in Burkina Faso, surveys were carried out in 2015 and 2016 among 316 producers in the West and North zones of the country. Ninety percent of ... [more ▼]

To assess the phytosanitary practices of tomato growers in Burkina Faso, surveys were carried out in 2015 and 2016 among 316 producers in the West and North zones of the country. Ninety percent of pesticides used by producers are purchased in local markets without guarantee of conformity or quality. Lambda-cyhalothrin of the pyrethroids family was the most used active substance. The use for tomato crop of cotton pesticides increased strongly between 2015 and 2016 (þ71%). The doses used by producers are higher than the recommended ones. More than 70% of the market gardeners do not observe any measure of adequate protection from the preparation of the mixture until the end of the treatments. The respect of preharvest interval depends mostly of the crop health status and does not follow the recommendations. Empty containers of pesticides are left in fields by 53% of the farmers. These results show that the phytosanitary practices of tomato producers are unsuitable and potentially harmful to the health of farmers and consumers and to the environment. [less ▲]

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See detailA water retention model for compacted bentonites
Dieudonné, Anne-Catherine ULiege; Della Vecchia, Gabriele; Charlier, Robert ULiege

in Canadian Geotechnical Journal (2017)

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See detailFluctuations of Attentional Networks and Default Mode Network during the Resting State Reflect Variations in Cognitive States: Evidence from a Novel Resting-state
Van Calster, Laurens ULiege; D'Argembeau, Arnaud ULiege; SALMON, Eric ULiege et al

in Journal of Cognitive Neuroscience (2017)

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's ... [more ▼]

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's mind. In this study, we focused on the default mode network (DMN) and attentional networks and investigated their association with distinct mental states when participants are not performing an explicit task. To investigate the range of possible cognitive experiences more directly, this study proposes a novel method of resting-state fMRI experience sampling, informed by a phenomenological investigation of the fluctuation of mental states during the resting state. We hypothesized that DMN activity would increase as a function of internal mentation and that the activity of dorsal and ventral networks would indicate states of top–down versus bottom–up attention at rest. Results showed that dorsal attention network activity fluctuated as a function of subjective reports of attentional control, providing evidence that activity of this network reflects the perceived recruitment of controlled attentional processes during spontaneous cognition. Activity of the DMN increased when participants reported to be in a subjective state of internal mentation, but not when they reported to be in a state of perception. This study provides direct evidence for a link between fluctuations of resting-state neural activity and fluctuations in specific cognitive processes. [less ▲]

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See detailPostoperative care in endoscopic sinus surgery: a critical review.
Eloy, Philippe; Andrews, Peter; POIRRIER, Anne-Lise ULiege

in Current Opinion in Otolaryngology & Head & Neck Surgery (2017), 25(1), 35-42

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard ... [more ▼]

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard treatment for medically refractive disease. Postoperative care is recommended by international leaders as an important part of the patient's management. This article is a critical review and discussion focusing on postoperative care, which is based on expert opinion, clinical studies, randomized controlled trials and meta-analysis studies. RECENT FINDINGS: Postoperative care including nasal rinsing, topical corticosteroids, antibiotics and avoidance of nasal packing are unanimously considered to be the cornerstone of best practice following FESS. However, the effectiveness of in-office nasal debridement is still under debate. SUMMARY: There is a lack of consensus regarding the necessity of performing in-office nasal debridement and the majority of clinicians carry out their postoperative care according to experience and their own preference. This is often determined by the extent of surgery performed, the severity of the postoperative inflammation, as well as being dependent on the patient's discomfort, the time constraints associated with postoperative care and the costs associated with additional appointments. Ideally, nasal debridement should be performed by the operating surgeon under endoscopic control both gently and atraumatically. [less ▲]

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See detailA multivariable prediction model for pegvisomant dosing: monotherapy and in combination with long-acting somatostatin analogues
Franck, Sanne Elisabeth; Korevaar, Tim; PETROSSIANS, Patrick ULiege et al

in European Journal of Endocrinology (2017)

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and ... [more ▼]

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. Objective: To identify predictors of the PEGV dose required to normalize insulin-like growth factor I (IGF-I) levels during PEGV monotherapy and in combination with long-acting somatostatin analogues (LA-SSAs). 188) were meta-analysed as a form of external replication to study the predictors of PEGV dosing in addition to LA-SSA, the LAS (n=83) was used to study the predictors of PEGV monotherapy dosing. Multivariable regression models were used to identify predictors of the PEGV dose required to normalize IGF-I levels. <0.001, p=<0.001, p=0.028 and p=0.047, respectively). Taken together, these characteristics predicted the PEGV normalization dose correctly in 63.3% of all patients within a range of +/- 60 mg/week (21.3% within a range of +/- 20 mg/week). For monotherapy, only weight was associated with the PEGV normalization dose (p=<0.001) and predicted this dosage correctly in 77.1% of all patients within a range of +/- 60 mg/week (31.3% within a range of +/- 20 mg/week). Conclusion: In this study, we show that IGF-I levels, weight, height and age can contribute to define the optimal PEGV dose in order to normalize IGF-I levels in addition to LA-SSA. For PEGV monotherapy, only the patient's weight was associated with the IGF-I normalization PEGV dosage. [less ▲]

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See detailPrevalence of Frailty in Nursing Home Residents According to Various Diagnostic Tools
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; GILLAIN, Sophie ULiege et al

in Journal of Frailty & Aging (2017), 6(3), 122-8

Background: Although the theoretical foundations of frailty are well established in the literature, it remains an evolving concept lacking any unique definition or diagnostic criteria for use in clinical ... [more ▼]

Background: Although the theoretical foundations of frailty are well established in the literature, it remains an evolving concept lacking any unique definition or diagnostic criteria for use in clinical practice and epidemiological research. No consensus exists about the accurate prevalence rates of frailty. The various operational definitions of frailty can at least partly explain such discrepancies. Objective: To compare the prevalence of frailty, measured with different diagnostic tools, among elderly nursing home residents. Design: This is an analysis of baseline data collected among the SENIOR (Sample of Nursing home Elderly Individuals: an Observational Research) cohort. Setting: Nursing homes. Population: A total of 662 volunteer subjects from 28 nursing homes were included in this analysis. Among them, the mean age was 83.2 ± 8.99 years and 484 (72.5%) of them were women. Measurement: The percentages of frail and non-frail subjects were calculated according to 10 different definitions. Results: Prevalence of frailty varies from 1.70% (Frailty Index) to 76.3% (Groningen Frailty Indicator) depending on the tool used. Conclusions: The prevalence of frailty is highly dependent on the diagnostic tool used. It would be necessary to reach a consensus on which diagnostic tools to use if one wishes to have comparable data obtained in epidemiological studies. [less ▲]

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See detailEffective components of interventions in juvenile justice facilities: How to take care of delinquent youths?
Mathys, Cécile ULiege

in Children and Youth Services Review (2017), 73

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in ... [more ▼]

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in juvenile justice facilities. The effectiveness of remedial measures to best address the sources of youths' delinquent behaviors and the performance of juvenile justice system are discussed first, and then two theoretical frameworks of rehabilitative models are described that are commonly used with delinquent youths. Finally, specific recommendations for enhancing treatment in juvenile justice facilities with regard to the content of interventions, social climate, and youth motivation to engage in treatment are described and explained in a way intended to help caregivers and practitioners, supervisors of juvenile justice facilities, and policy makers improve the daily life of youths placed in this kind of environment. [less ▲]

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See detailProduction of FucoPol by Enterobacter A47 using waste tomato paste by-product as sole carbon source
Antunes, iylvia; Freitas, Filomena; Sevrin, Chantal ULiege et al

in Bioresource Technology (2017), 227

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See detailCXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone.
Goffart, Nicolas ULiege; Lombard, Arnaud; Lallemand, François ULiege et al

in Neuro-Oncology (2017), 19(1), 66-77

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that ... [more ▼]

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that might arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated that GSCs are able to escape the tumor mass and preferentially colonize the adult subventricular zone (SVZ). At a distance from the initial tumor site, these GSCs might therefore represent a high-quality model of clinical resilience to therapy and cancer relapses as they specifically retain tumor-initiating abilities. METHOD: While relying on recent findings that have validated the existence of GSCs in the human SVZ, we questioned the role of the SVZ niche as a potential GSC reservoir involved in therapeutic failure. RESULTS: Our results demonstrate that (i) GSCs located in the SVZ are specifically resistant to radiation in vivo, (ii) these cells display enhanced mesenchymal roots that are known to be associated with cancer radioresistance, (iii) these mesenchymal traits are specifically upregulated by CXCL12 (stromal cell-derived factor-1) both in vitro and in the SVZ environment, (iv) the amount of SVZ-released CXCL12 mediates GBM resistance to radiation in vitro, and (v) interferes with the CXCL12/CXCR4 signalling system, allowing weakening of the tumor mesenchymal roots and radiosensitizing SVZ-nested GBM cells. CONCLUSION: Together, these data provide evidence on how the adult SVZ environment, through the release of CXCL12, supports GBM therapeutic failure and potential tumor relapse. [less ▲]

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See detailDiscrimination of three genetically close Aspergillus species by using high resolution melting analysis applied to indoor air as case study.
Libert, Xavier; Packeu, Ann; Bureau, Fabrice ULiege et al

in BMC Microbiology (2017), 17(1), 84

BACKGROUND: Indoor air pollution caused by fungal contamination is suspected to have a public health impact. Monitoring of the composition of the indoor airborne fungal contaminants is therefore important ... [more ▼]

BACKGROUND: Indoor air pollution caused by fungal contamination is suspected to have a public health impact. Monitoring of the composition of the indoor airborne fungal contaminants is therefore important. To avoid problems linked to culture-dependent protocols, molecular methods are increasingly being proposed as an alternative. Among these molecular methods, the polymerase chain reaction (PCR) and the real-time PCR are the most frequently used tools for indoor fungal detection. However, even if these tools have demonstrated their appropriate performance, some of them are not able to discriminate between species which are genetically close. A solution to this could be the use of a post-qPCR high resolution melting (HRM) analysis, which would allow the discrimination of these species based on the highly accurate determination of the difference in melting temperature of the obtained amplicon. In this study, we provide a proof-of-concept for this approach, using a dye adapted version of our previously developed qPCR SYBR(R)Green method to detect Aspergillus versicolor in indoor air, an important airborne fungus in terms of occurrence and cause of health problems. Despite the good performance observed for that qPCR method, no discrimination could previously be made between A. versicolor, Aspergillus creber and Aspergillus sydowii. METHODS: In this study, we developed and evaluated an HRM assay for the discrimination between A. versicolor, Aspergillus creber and Aspergillus sydowii. RESULTS: Using HRM analysis, the discrimination of the 3 Aspergillus species could be made. No false positive, nor false negatives were observed during the performance assessment including 20 strains of Aspergillus. The limit of detection was determined for each species i.e., 0.5 pg of gDNA for A. creber and A. sydowii, and 0.1 pg of gDNA for A. versicolor. The HRM analysis was also successfully tested on environmental samples. CONCLUSION: We reported the development of HRM tools for the discrimination of A. versicolor, A. creber and A. sydowii. However, this study could be considered as a study case demonstrating that HRM based on existing qPCR assays, allows a more accurate identification of indoor air contaminants. This contributes to an improved insight in the diversity of indoor airborne fungi and hence, eventually in the causal link with health problems. [less ▲]

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See detailSémiologie de la chaleur
Badir, Sémir ULiege

in Linx (2017), 74

Dans le présent essai, on se propose, à l’instar de Barthes, « d’ouvrir un dossier » destiné à la chaleur et à l’expérience qu’on en a. C’est à une sorte d’exploration qu’on invite le lecteur. On ... [more ▼]

Dans le présent essai, on se propose, à l’instar de Barthes, « d’ouvrir un dossier » destiné à la chaleur et à l’expérience qu’on en a. C’est à une sorte d’exploration qu’on invite le lecteur. On se laissera conduire par un état de langue — celui de la langue française d’aujourd’hui — en gageant que la chaleur peut se donner à comprendre sans autres repères pour son examen que ceux du sentiment linguistique. Dès lors en effet que son expérience est a priori partagée par tout un chacun, suivant un très grand nombre de conditions et de circonstances, au sein de cette langue française appréhendée comme un trésor, on cherchera à répondre à la question : qu’est-ce (au juste) que la chaleur ? [less ▲]

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See detailBehavioral and Immunological Features Promoting the Invasive Performance of the Harlequin Ladybird Harmonia axyridis
Verheggen, François ULiege; Vogel, Heiko; Vilcinskas, Andreas

in Frontiers in Ecology and Evolution (2017), 5(156),

The harlequin ladybird Harmonia axyridis is now established as a model to test hypotheses explaining why some species become successfully invasive, while others, even closely related ones, do not. In this ... [more ▼]

The harlequin ladybird Harmonia axyridis is now established as a model to test hypotheses explaining why some species become successfully invasive, while others, even closely related ones, do not. In this review, we evaluate behavioral and immunological features that may play a role in the invasive performance of this model species. We discuss the behavioral traits and associated semiochemicals that promote the invasive success of H. axyridis. In particular, we consider (1) the aggregative behavior and the particular role of long-chain hydrocarbons; (2) the importance of sex pheromones and non-volatile chemicals in mate location and selection; (3) the use of allelochemicals for prey location; and (4) the nature of chemicals that protect against natural enemies. We also highlight the superior immune system of H. axyridis, which encompasses a broader spectrum of antimicrobial peptides (and higher inducible expression levels) compared with native ladybird beetles such as Adalia bipunctata and Coccinella septempunctata. The chemical defense compound harmonine and the antimicrobial peptides are thought to confer resistance against the abundant microsporidia carried by H. axyridis. These parasites can infect and kill native ladybird species feeding on H. axyridis eggs or larvae, supporting the hypothesis that intraguild predation plays a role in the ability of H. axyridis to outcompete native ladybird species in newly-colonized areas. [less ▲]

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See detailAlpha-lipoic acid impairs body weight gain of young broiler chicks via modulating peripheral AMPK.
Wang, Yufeng; Everaert, Nadia ULiege; Song, Zhigang et al

in Comparative Biochemistry and Physiology Part A : Molecular & Integrative Physiology (2017), 211

In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was ... [more ▼]

In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was aimed to explore the potential role of hepatic AMPK in the energy homeostasis of broiler chickens. Diets with 0, 0.05% or 0.1% alpha-lipoic acid (alpha-LA), a known AMPK inhibitor were provided to broiler chicks for 7days. As a result, alpha-LA supplementation decreased the relative growth rate of broiler chicks. Hepatic AMPKalpha2 mRNA levels were significantly upregulated by dietary alpha-LA, in concert with the increased phosphorylated AMPKalpha protein levels. In addition, hepatic FAS mRNA levels together with the malonyl-CoA to total CoA ester ratio were reduced by alpha-LA supplementation. Moreover, the hepatic phosphorylated glycogen synthase levels were increased resulting in a markedly decreased hepatic glycogen content. In conclusion, dietary alpha-LA supplementation decreased the in vivo hepatic glycogenesis and lipogenesis via stimulating hepatic AMPKalpha mRNA levels and the phosphorylated gene product. The stimulatory effect of alpha-LA on hepatic AMPK mRNA and pAMPKalpha protein levels together with our previous observations regarding its inhibitory effect on hypothalamic AMPK may have altered the energy balance and hence impaired body weight gain of broiler chicks. [less ▲]

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See detailSol-gel derived ZnO:Y nanostructured films: Structural and optical study
Ivanova, T.; Harizanova, A.; Koutzarova, T. et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2017), 532

The study is focused on the sol-gel derived ZnO:Y nanostructured films with different yttrium concentrations. The sol-gel Y doped ZnO films have been successfully deposited on Si and quartz substrates by ... [more ▼]

The study is focused on the sol-gel derived ZnO:Y nanostructured films with different yttrium concentrations. The sol-gel Y doped ZnO films have been successfully deposited on Si and quartz substrates by spin coating method. The effect of thermal treatment is researched depending on their structural and optical properties. The annealing temperatures are changed in the range of 300–800 °C. XRD patterns reveal that the crystallization of Y doped ZnO films is significantly deteriorated and the broader and less intense XRD lines are observed compared to single ZnO. The XRD analysis shows that increasing the yttrium contents and the annealing temperatures lead to the formation of cubic yttrium oxide. This conclusion has been confirmed by FTIR analysis. Optical transmittance in the visible spectral range diminishes with yttrium doping especially significant for ZnO:Y films with highest Y content. The determined optical band gaps of ZnO:Y films are wider compared to single ZnO. © 2017 Elsevier B.V. [less ▲]

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See detailQuel cours de didactique professionnelle pour le CAPAES ? Quelques réflexions sur base d’une expérience en géographie
Merenne-Schoumaker, Bernadette ULiege

in Didactiques en Pratique (2017), 3

L'objectif de la publication est de s'interroger sur la formation CAPAES à travers l'un de ses modules : la didactique professionnelle, un cours spécifique créé par l’Université de Liège et confié aux ... [more ▼]

L'objectif de la publication est de s'interroger sur la formation CAPAES à travers l'un de ses modules : la didactique professionnelle, un cours spécifique créé par l’Université de Liège et confié aux professeurs de didactique des différentes disciplines. Nous traitons de sa place dans la formation ainsi que des problèmes liés à son organisation avant de tenter un bilan autour de trois questions : didactique professionnelle ou didactique disciplinaire ? Comment répondre aux besoins très différenciés des candidats en formation ? Comment faire face aux difficultés rencontrées? Ces questions sont celles que nous nous sommes posées tout au long des 14 années où nous avons assumé cette tâche, soit de 2002 à 2016 [less ▲]

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See detailFinancial Impacts of Priority Swine Diseases to Pig Farmers in Red River and Mekong River Delta, Vietnam.
Pham, T. T. Hoa; Antoine-Moussiaux, Nicolas ULiege; Grosbois, V. et al

in Transboundary and Emerging Diseases (2017)

A study was conducted between May 2013 and August 2014 in three provinces of Vietnam to investigate financial impacts of swine diseases in pig holdings in 2010-2013. The aim of the study was to quantify ... [more ▼]

A study was conducted between May 2013 and August 2014 in three provinces of Vietnam to investigate financial impacts of swine diseases in pig holdings in 2010-2013. The aim of the study was to quantify the costs of swine diseases at producer level in order to understand swine disease priority for monitoring at local level. Financial impacts of porcine reproductive and respiratory syndrome (PRRS), foot and mouth disease (FMD), and epidemic diarrhoea were assessed for 162 pig holders in two Red River Delta provinces and in one Mekong River Delta province, using data on pig production and swine disease outbreaks at farms. Losses incurred by swine diseases were estimated, including direct losses due to mortality (100% market value of pig before disease onset) and morbidity (abortion, delay of finishing stage), and indirect losses due to control costs (treatment, improving biosecurity and emergency vaccination) and revenue foregone (lower price in case of emergency selling). Financial impacts of swine diseases were expressed as percentage of gross margin of pig holding. The gross margin varied between pig farming groups (P < 0.0001) in the following order: large farm (USD 18 846), fattening farm (USD 7014) and smallholder (USD 2350). The losses per pig holding due to PRRS were the highest: 41% of gross margin for large farm, 38% for fattening farm and 63% for smallholder. Cost incurred by FMD was lower with 19%, 25% and 32% of gross margin of pig holding in large farm, fattening farm and smallholder, respectively. The cost of epidemic diarrhoea was the lowest compared to losses due to PRRS and FMD and accounted for around 10% of gross margin of pig holding in the three pig farming groups. These estimates provided critical elements on swine disease priorities to better inform surveillance and control at both national and local level. [less ▲]

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See detailPhylotranscriptomic consolidation of the jawed vertebrate timetree.
Irisarri, Iker; Baurain, Denis ULiege; Brinkmann, Henner et al

in Nature ecology & evolution (2017), 1(9), 1370-1378

Phylogenomics is extremely powerful but introduces new challenges as no agreement exists on "standards" for data selection, curation and tree inference. We use jawed vertebrates (Gnathostomata) as model ... [more ▼]

Phylogenomics is extremely powerful but introduces new challenges as no agreement exists on "standards" for data selection, curation and tree inference. We use jawed vertebrates (Gnathostomata) as model to address these issues. Despite considerable efforts in resolving their evolutionary history and macroevolution, few studies have included a full phylogenetic diversity of gnathostomes and some relationships remain controversial. We tested a novel bioinformatic pipeline to assemble large and accurate phylogenomic datasets from RNA sequencing and find this phylotranscriptomic approach successful and highly cost-effective. Increased sequencing effort up to ca. 10Gbp allows recovering more genes, but shallower sequencing (1.5Gbp) is sufficient to obtain thousands of full-length orthologous transcripts. We reconstruct a robust and strongly supported timetree of jawed vertebrates using 7,189 nuclear genes from 100 taxa, including 23 new transcriptomes from previously unsampled key species. Gene jackknifing of genomic data corroborates the robustness of our tree and allows calculating genome-wide divergence times by overcoming gene sampling bias. Mitochondrial genomes prove insufficient to resolve the deepest relationships because of limited signal and among-lineage rate heterogeneity. Our analyses emphasize the importance of large curated nuclear datasets to increase the accuracy of phylogenomics and provide a reference framework for the evolutionary history of jawed vertebrates. [less ▲]

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See detailMetabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach
Govinden-Soulange, J.; Lobine, D.; Frederich, Michel ULiege et al

in South African Journal of Botany (2017), 108

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect ... [more ▼]

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. Nuclear magnetic resonance spectroscopy, DNA sequencing and antioxidant profiles of these Aloes were studied. Principal component analysis following 1H NMR revealed the specificity of the Mascarene Aloes relative to Aloe vera. The superior free radical scavenging ability of A. purpurea, A. macra and A. tormentorii as compared to other Aloes was also unveiled. Phylogenetic analyses of chloroplast genes and ITS region sequences of these Mascarene Aloes were done using maximum parsimony and Bayesian analysis. Mascarene Aloes clustered within one clade separate from Aloe vera confirming their relative recent emergence in this genus. Results from this study showed that there is sufficient evidence at the metabolomic and molecular level to distinguish between Aloe ​purpurea from Mauritius and that of Reunion. © 2016 SAAB [less ▲]

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See detailCardiopulmonary exercise testing is a better outcome predictor than exercise echocardiography in asymptomatic aortic stenosis.
Domanski, Olivia; Richardson, Marjorie; Coisne, Augustin et al

in International Journal of Cardiology (2017), 227

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship ... [more ▼]

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship between peak VO2 and AS severity criteria derived from rest and supine exercise echocardiography (SEE) has never been explored. OBJECTIVES: We aimed to determine whether low peak VO2 (<85% of predicted value) is associated with severity parameters in SEE, and poor clinical outcome. METHODS: Fifty one asymptomatic patients (mean age of 54+/-21years) with moderate to severe aortic stenosis (Vmax>3m/s) and left ventricle ejection fraction>50% prospectively underwent resting and SEE and cardiopulmonary exercise testing (CPX). RESULTS: Peak VO2 was lower than expected (21.9+/-7.4mL/kg/min), i.e. <85% of predicted value in 57% patients, secondary to cardiac limitation in most of them (69%). In multiple regression analysis, age, BMI and female gender were the only independent determinants of peak VO2. Interestingly no parameter derived from SEE was associated with peak VO2. After 21+/-7month follow-up, no patient died, 20 underwent cardiac surgery. Peak VO2<85% of predicted value was associated with lower event free survival compared to normal peak VO2 (57%+/-11% vs 93+/-6%, p=0.036) whereas no exercise echocardiographic parameter could predict such events. Peak VO2>/=85% had a negative predictive value of 97%. CONCLUSION: CPX detects a high proportion of false asymptomatic AS patients with poorer outcome that cannot be predicted by SEE markers of AS severity. Assessment of aerobic capacity should be part of current approach within a "watchful waiting" strategy. [less ▲]

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See detailFaire vivre une expérience d’évaluation mutuelle en formation initiale : quelle transposition vers les pratiques d’enseignement projetées ?
Goffin, Christelle ULiege; Fagnant, Annick ULiege

in Contextes et Didactiques (2017), 9

Dans une étude préalable menée en Belgique francophone (Fagnant et Goffin, à paraître), nous avons notamment montré que les futurs enseignants du secondaire supérieur (grades 10 - 12) témoignaient ... [more ▼]

Dans une étude préalable menée en Belgique francophone (Fagnant et Goffin, à paraître), nous avons notamment montré que les futurs enseignants du secondaire supérieur (grades 10 - 12) témoignaient d’expériences limitées en matière d’évaluation formative : leur vécu en tant qu’élève faisait davantage état de pratiques d’auto-notation que de réelles expériences d’autoévaluation. Voulant prendre en compte le décalage entre le cadre légal qui prescrit la mise en œuvre d’évaluations formatives et la réalité des classes où ce type d’évaluation semble être peu pratiqué, nous avons tenté d’agir dès la formation initiale. Ainsi, nous avons fait vivre à ces futurs enseignants une expérience d’évaluation mutuelle en tant qu’étudiant universitaire dans un cours pluridisciplinaire tout en les faisant réfléchir à la transposition de ces acquis vers leurs pratiques de stage en tant qu’enseignant d’une discipline donnée. Cet article présente le dispositif mis en place, tout en y portant un regard critique documenté par deux sources d’informations. La première concerne les commentaires rédigés par les étudiants sur ce qu’ils ont retenu du dispositif expérimenté. La seconde porte sur les pratiques d’évaluation que les futurs enseignants ont développées ou pourraient développer en classe avec leurs élèves, en lien avec l’expérience vécue en formation. Les analyses mettent en évidence que cette expérience a pu, dans une certaine mesure, nourrir leurs processus d’apprentissage et leur développement professionnel. [less ▲]

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See detailComparison of soil water potential sensors: a drying experiment
Degré, Aurore ULiege; van der Ploeg, Martine; Caldwell, Todd et al

in Vadose Zone Journal (2017), 16(4),

The soil water retention curve (WRC) plays a major role in soil’s hydrodynamic behaviour. Many measurement techniques are currently available for determining WRC in the laboratory. Direct in situ WRC can ... [more ▼]

The soil water retention curve (WRC) plays a major role in soil’s hydrodynamic behaviour. Many measurement techniques are currently available for determining WRC in the laboratory. Direct in situ WRC can be obtained from simultaneous soil moisture and water potential readings covering a wide tension range, from saturation to wilting point. There are many widely used soil moisture probes. Whereas near-saturation tension can be measured using water-filled tensiometers, wider ranges of water potential require new, more expensive and less widely used probes. This paper reports on a comparison of three types of soil water potential sensors that could allow us to measure water potential in the field, with a range relevant to water uptake by plants. Polymer tensiometers (POTs), MPS-2 probes and pF-meters were compared, in a controlled drying experiment. The study showed that the POTs and MPS-2 probes had good reliability in their respective range. Combined with a soil moisture probe, these two sensors can provide observed WRCs. The pF-meters below -30 kPa were inaccurate and their response was sensitive to measurement interval, with greater estimated suction at shorter measurement intervals. Recommendations are provided for future tests. In situ-WRC can provide supplementary information, particularly with regard to its spatial and temporal variability. It could also improve the results of other measurement techniques, such as geophysical observations. [less ▲]

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See detailNuclear Motion Driven Ultrafast Photodissociative Charge Transfer of the PENNA Cation: An Experimental and Computational Study
Sun, Shoutian; Mignolet, Benoît ULiege; Fan, lin et al

in Journal of Physical Chemistry A (2017), 121(7), 1442

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See detailEffects of the conversion of intensive grasslands into Christmas tree plantations on bird assemblages
Gailly, Robin ULiege; Paquet, Jean-Yves; Titeux, Nicolas et al

in Agriculture, Ecosystems & Environment (2017), 247

Over the last decade, the conversion of annual-rotation based crops or grassland areas into non-food perennial crops has been increasingly prevalent in European farming systems. This shift is associated ... [more ▼]

Over the last decade, the conversion of annual-rotation based crops or grassland areas into non-food perennial crops has been increasingly prevalent in European farming systems. This shift is associated with major changes in management practices and has created new environmental conditions and resources for wildlife. Impacts on birds have been examined for bioenergy agricultural systems, such as miscanthus plantations and short-rotation willow coppice. However, they remain largely unknown for Christmas tree plantations (CTPs) that have recently increased considerably in some European countries. We examined the extent to which CTPs alter bird species assemblages in the farmland areas of southern Belgium, where they mainly replace intensive grassland. The abundance of birds was recorded during the breeding season in randomly selected sites located in grassland and in CTP. Results show that introduction of CTP into landscapes dominated by grassland with low hedge densities locally increases bird species richness and abundance without leading to biotic homogenization. Differences in species richness and abundance between grassland and CTP decrease with increasing hedge densities. A community analysis indicates that the plantation of Christmas trees enriches the bird assemblage of intensive grassland areas. In intensive grassland with few hedges, small-size CTPs could constitute an option to increase structural heterogeneity and provide new potential breeding conditions for some farmland birds. However, questions remain about the genuine quality of the resources available in CTP and further research is needed to examine the breeding success and survival of birds that settle in this type of habitat. [less ▲]

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See detailLe passage du jeu à la création : le cas du jeu vidéo amateur
Hurel, Pierre-Yves ULiege

in Sciences du Jeu (2017), 7

La création de jeux vidéo en amateur à l’aide de logiciels (Unity, Construct 2, RPG Maker, etc.) a été peu étudiée. Pourtant, cette pratique importante sur le plan quantitatif et hétérogène sur le plan ... [more ▼]

La création de jeux vidéo en amateur à l’aide de logiciels (Unity, Construct 2, RPG Maker, etc.) a été peu étudiée. Pourtant, cette pratique importante sur le plan quantitatif et hétérogène sur le plan qualitatif permet notamment d’interroger une des marges du jeu : celle de la création. Comment les joueurs passent-ils à la création ? S’agit-il d’un prolongement du jeu ? Et si oui, qu’est-ce qui est prolongé dans ce cas ? Ce sont ces questions que nous abordons dans cet article, sur la base des premiers résultats d’une enquête ethnographique en cours. Nous mettons d’abord à jour plusieurs dynamiques caractérisant l’activité de ces créateurs. Puis, en nous fondant sur ces résultats et en introduisant la notion d’amateurisme dans le champ des sciences du jeu, nous proposons de problématiser la question du prolongement ludique au regard de l’activité réflexive que constitue le goût. [less ▲]

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See detailAre Th17 Cells Playing a Role in Immunity to Dermatophytosis?
Heinen, Marie-Pierre ULiege; Cambier, Ludivine ULiege; Fievez, Laurence ULiege et al

in Mycopathologia (2017), 182(1), 251-261

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See detailNEW SEDIMENTOLOGICAL DATA FROM TRIASSIC TO JURASSIC BOREHOLES (BONNERT, HAEBICHT, GROUFT, GRUND, CONSDORF) AND SECTIONS (TONTELANGE, DIFFERDANGE, RUMELANGE) FROM SOUTHERN BELGIUM AND LUXEMBOURG
Boulvain, Frédéric ULiege; Belanger, Isabelle; Colbach, Robert et al

in Professional Papers of the Geological Survey of Belgium (2017), 319

This study offers a detailed description of a series of Triassic to Jurassic representative boreholes (Bonnert, Haebicht, Grouft, Grund, Consdorf) and sections (Tontelange, Differdange, Rumelange) from ... [more ▼]

This study offers a detailed description of a series of Triassic to Jurassic representative boreholes (Bonnert, Haebicht, Grouft, Grund, Consdorf) and sections (Tontelange, Differdange, Rumelange) from southern Belgium and the Grand-Duchy of Luxembourg. Investigations provide information about microfacies, paleoenvironments and magnetic susceptibility (MS). Three sets of microfacies, corresponding to three different sedimentary systems were needed in order to address the complexity of the paleoenvironments: a transgressive mixed siliciclastic-carbonate ramp system for the Triassic to Lower Jurassic (Toarcian) interval (microfacies TT1-8), and, for the Middle Jurassic, an early transgressive low productivity mixed ramp system for the Aalenian (microfacies A1-2) and a transgressive carbonate ramp for the Lower Bajocian (microfacies B1-3). A comparison of the MS and microfacies curves shows a clear correlation between the two, suggesting that the MS signal is primary. Moreover, the MS values regularly decrease from the marine distal (TT1) to the marine proximal microfacies (TT5), with relatively weak mean MS values for sandstones and limestones, and high mean MS values for marls, argillites and ironstone. This relationship is interpreted as the consequence of local water agitation in the shallower parts of a ramp, preventing the detrital particles from settling down and to the higher sedimentation rate that dilutes the magnetic and/or paramagnetic minerals. [less ▲]

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See detailA photocatalyst of sulphur depleted monolayered molybdenum sulfide nanocrystals for dye degradation and hydrogen evolution reaction
Lin, Liangxu; Miao, Naihua; Huang, Juntong et al

in Nano Energy (2017), 38

Molybdenum disulfide (MoS2) has a theoretical catalytic activity comparable to Pt but in practice is a poor catalyst in bulk form due to the scarcity of metal edge sites and low electrical conductivity ... [more ▼]

Molybdenum disulfide (MoS2) has a theoretical catalytic activity comparable to Pt but in practice is a poor catalyst in bulk form due to the scarcity of metal edge sites and low electrical conductivity. Recent developments on MoS2 monolayers (MLs) are more encouraging in developing cheap and efficient catalysts, but the majority metal atoms are on the basal plane and catalytically inactive. The rapid recombination of the electron-hole pairs and electronic band structure of the most stable 2H-MoS2 MLs are also unsuitable for efficient photocatalysis, especially for solar-driven water splitting. Here, we show that reducing the lateral size and creating sulphur (S) vacancies of MoS2 MLs not only increases dramatically the density of catalytically active sites, but also adjusts the band structure to become highly suitable for solar-driven catalysis. In addition, this preparation efficiently avoids fast charge recombination associated with MoS2, improves light harvesting, and gives a newly formed metallic state to transfer electrons for photocatalytic reactions. By way of example, we have demonstrated remarkable photocatalytic degradation of methylene blue (MB) and methylene orange (MO) dyes using the Sdepleted Mo-S nanocrystals (NCs, 2–25 nm). The NCs are also promising to efficiently generate hydrogen (H2) from water with sacrificial reagents and solar light irradiation. Our study shows how careful design and modification of materials can result in highly efficient photocatalysts, which give considerable opportunities of the transition metal dichalcogenides (TMDs) beyond just MoS2 to develop highly efficient and economic catalysts. [less ▲]

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See detailRelevance of adding a triangular dynamic cushion on a traditional chair: A 3D-analysis of seated schoolchildren
Fettweis, Tatiana ULiege; Onkelinx, Marie-Noëlle; Schwartz, Cédric ULiege et al

in Clinical Biomechanics (2017)

Background: Low back pain is highly prevalent in the general population and is even reported as early as at primary school. A poor sitting position has been suggested as an etiologic factor. This study ... [more ▼]

Background: Low back pain is highly prevalent in the general population and is even reported as early as at primary school. A poor sitting position has been suggested as an etiologic factor. This study analysed, in primary schoolchildren, the influence of a triangular dynamic cushion that aims to help children maintain their physiological lumbar lordosis and to induce movement to reduce the static effect of the sitting position. Methods: Thirty 8-year-old children took part in this study. A 3D analysis combined with electromyography was used to evaluate the biomechanics and the related muscle activation in two sitting positions (with and without a triangular cushion on a horizontal stool) during a 15-minute working task. In addition, the force of the feet on the ground was assessed with a force plate. Findings: The cushion improved the trunk–thighs angle, lumbar lordosis, anterior pelvis tilt, and feet support on the ground (p < 0.0001). In addition, sitting on the cushion appeared to be more dynamic (p < 0.05) and induced a decrease of the lumbar paravertebral muscle activity (p < 0.01). Interpretation: Sitting on a dynamic triangular cushion tends to favour the “ideal” siting position usually described in the literature and to decrease the level of paravertebral muscle recruitment. Seeing that sitting position is a risk factor to develop low back pain, the cushion could be a solution to prevent it. [less ▲]

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See detailExperimental validation of footprint models for eddy covariance CO2 flux measurements above grassland by means of natural and artificial tracers
Arriga, Nicola; Rannik, Üllar; Aubinet, Marc ULiege et al

in Agricultural and Forest Meteorology (2017), 242

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See detailCoupling agent-based, cellular automata and logistic regression into a hybrid urban expansion model (HUEM)
El Saeid Mustafa, Ahmed Mohamed ULiege; Cools, Mario ULiege; Saadi, Ismaïl ULiege et al

in Land Use Policy (2017), 69C

Several methods for modeling urban expansion are available. Most of them are based on a statistical, a cellular automaton (CA) and/or an agent-based (AB) approach. Statistical and CA approaches are based ... [more ▼]

Several methods for modeling urban expansion are available. Most of them are based on a statistical, a cellular automaton (CA) and/or an agent-based (AB) approach. Statistical and CA approaches are based on the implicit assumption that people's behavior is not likely to change over the considered time horizon. Such assumption limits the ability to simulate long-term predictions as people's behavior changes over time. An approach to consider people's behavior is the use of an AB system, in which the decision-making process of agents needs to be parameterized. Most existing studies, which make use of empirical data to define the agents’ decision-making criteria, rely on intensive data collection efforts. The considerable data requirements limit the AB-system's ability to model a large study area, as the number of agents for which data on decision-making criteria is required, increases with the size of the study area. This paper presents a hybrid urban expansion model (HUEM) that integrates logistic regression (Logit), CA and AB approaches to simulate future urban development. A key feature of HUEM lies in its ability to address various people behaviors that are variable over time through AB relying on a sample approach that combines Logit and CA. Three agent sets are defined; developer agents, farmer agents and planning permission authority agent. The agents’ decision-making process is parameterized using CA and Logit models. The interactions of the agents are simulated through a series of rules. To assess HUEM performance, it is calibrated for Wallonia (Belgium) to simulate urban expansion between 1990 and 2000. Calibration results are then assessed by comparing the 2000 simulated map and the actual 2000 land-use map. Furthermore, the performance of HUEM is compared to a number of typical spatial urban expansion models, i.e. Logit model, CA model and CA-Logit to assess the added-value of HUEM. The comparison shows the performance of HUEM is better than other models in terms of allocation ability. [less ▲]

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See detailEfficient ANOVA for directional data
Ley, Christophe; Swan, Yvik ULiege; Verdebout, Thomas

in Annals of the Institute of Statistical Mathematics (2017)

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See detailTransatlantic Encounters. A Review of Nicolas Labarre’s Heavy Metal, l’autre Métal Hurlant
Crucifix, Benoît ULiege

in International Journal of Comic Art [=IJOCA] (2017), 19(1), 636-640

Review of Nicolas Labarre, Heavy Metal, l'autre Métal Hurlant, Bordeaux: Presses universitaires de Bordeaux, 2017.

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See detailOffensive de la Russie contre l'autorité de la jurisprudence européenne relative au droit de vote des détenus: la Cour constitutionnelle russe et le contrôle du caractère "exécutoire" d'un arrêt de la Cour européenne des droits de l'homme
Rosoux, Géraldine ULiege

in Revue Trimestrielle des Droits de l'Homme (2017)

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère ... [more ▼]

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère exécutoire d'un arrêt de la Cour européenne des droits de l'homme. Cette compétence a été exercée en ce qui concerne l'arrêt Anchugov et Gladkov c. Russie, relatif au droit de vote des détenus. [less ▲]

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See detailDesign sensitivity analysis for shape optimization based on the Lie derivative
Kuci, Erin ULiege; Henrotte, François ULiege; Duysinx, Pierre ULiege et al

in Computer Methods in Applied Mechanics & Engineering (2017)

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed ... [more ▼]

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed from differential geometry, shows that sensitivity of a performance function (i.e. any function of the solution of the problem) with respect to a given design variable can be represented mathematically as a Lie derivative, i.e. the derivative of that performance function along a flow representing the continuous shape modification of the geometrical model induced by the variation of the considered design variable. Theoretical formulae to express sensitivity analytically are demonstrated in detail in the paper, and applied to a nonlinear magnetostatic and a linear elastic problem, following both the direct and the adjoint approaches. Following the analytical approach, one linear system of which only the right-hand side needs be evaluated (the system matrix being known already) has to be solved for each of the design variables in the direct approach, or for each performance functions in the adjoint approach. A substantial gain in computation time is obtained this way compared to a finite difference evaluation of sensitivity, which requires solving a second nonlinear system for each design variable. This is the main motivation of the analytical approach. There is some freedom in the definition of the auxiliary flow that represents the shape modification. We present a method that makes benefit of this freedom to express sensitivity locally as a volume integral over a single layer of finite elements connected to both sides of the surfaces undergoing shape modification. All sensitivity calculations are checked with a finite difference in order to validate the analytic approach. Convergence is analyzed in 2D and 3D, with first and second order finite elements. [less ▲]

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See detailContribution of past and future self-defining event networks to personal identity
Demblon, Julie; D'Argembeau, Arnaud ULiege

in Memory (2017), 25

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See detailVignette therapeutique de l'etudiant. Quel medicament antidiabetique choisir chez un patient diabetique de type 2 avec insuffisance cardiaque ?
Scheen, André ULiege; Paquot, Nicolas ULiege

in Revue Médicale de Liège (2017), 72(9), 423-428

Heart failure is raising an increasing interest in patients with type 2 diabetes. Indeed, they combine different risk factors for this complication and they have time to develop it because they survive ... [more ▼]

Heart failure is raising an increasing interest in patients with type 2 diabetes. Indeed, they combine different risk factors for this complication and they have time to develop it because they survive longer due to a better prevention of atherothrombotic cardiovascular events. Beyond the classical therapy of heart failure, management should select the most suited glucose-lowering agents. Indeed, all do not have the same impact as some of them have proven their ability to reduce the risk of hospitalisation for heart failure whereas others are associated with an increased risk, either well proven or at least suspected. The aim of this clinical case is to discuss the use of glucose-lowering drugs in a patient with type 2 diabetes with or at risk to develop heart failure. [less ▲]

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See detailA new Late Devonian isoetalean lycopsid from New South Wales, Australia: Cymastrobus irvingii gen. et sp. nov.
Evreïnoff, M.; Meyer-Berthaud, B.; Decombeix, A.-L. et al

in Palaeontologia Electronica (2017), 20.3.45A

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See detailAssessment of the entering stock, migration dynamics and fish pass fidelity of european eel in the belgian meuse river
Nzau Matondo, Billy ULiege; Benitez, Jean-Philippe ULiege; Dierckx, Arnaud ULiege et al

in River Research & Applications (2017), 33

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to ... [more ▼]

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to distinguish resident and migrating eels. From April to September 2013, 435 eels (P50 length, 403 mm; range, 196–836 mm) were caught (daily maxima catch, 90 eels per day), 90% between 13 June and 1 August (50 days) and P50 on 19 July. Eels migrated mostly at 19–26 °C (P50, 24.4 °C), river discharge 65–314m3 s 1 (P50, 84m3 s 1), during the dark at 00:00–05:00 h and during both the waxing and waning phases of moonlight. From 396 eels tagged and released 0.3 km downstream of the Lixhe dam, 6.8% of them were recaptured, and 37.4% were detected. Migration flux was estimated at 7184 eels (0.863 t) using the markrecapture method and decreased to 1156 eels (0.139 t) using automatic transponder detection. Most eels probably migrated through a sluice located downstream of Lixhe to reach the upper Meuse via the Albert Canal. Eels moved almost independently to the configuration of the fish passes and their location, but most eels displayed fidelity to the fish pass where they were captured. Migrant eels showed a wide range of size and life stages, with a higher proportion of eels (80%) belonging to the yellow eel stage. A lower proportion of eels (6%) had a larger size and presented an advanced continental silvering process corresponding to the migrating stage before their transatlantic migration. Copyright © 2016 John Wiley & Sons, Ltd. [less ▲]

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See detailEquine Atypical Myopathy in the UK: Epidemiological characteristics of cases reported from 2011 to 2015 and factors associated with survival
Gonzalez-Medina, S.; Ireland, J. L.; Piercy, R. J. et al

in Equine Veterinary Journal (2017)

BACKGROUND: Equine atypical myopathy (AM) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from Acer pseudoplatanus tree. Despite the wide distribution of ... [more ▼]

BACKGROUND: Equine atypical myopathy (AM) is a toxic rhabdomyolysis associated with ingestion of hypoglycin A, derived typically in Europe, from Acer pseudoplatanus tree. Despite the wide distribution of this tree species in the UK, the number of cases reported annually varies, and there has been an apparent increase in prevalence in recent years. Although AM was first recognised in the UK, epidemiological studies have never been conducted focused solely on this country. OBJECTIVES: To describe the spatiotemporal distribution, presentation, treatment and outcome of AM cases reported in the UK. STUDY DESIGN: Retrospective case series. METHODS: British AM cases reported to the atypical myopathy alert website, between 2011 and 2015 were included (n = 224). Data were obtained via standardised epidemiological questionnaires from owners and veterinarians. Factors associated with survival were assessed using logistic regression. RESULTS: Most cases reported were from England (87.9%). Survival was 38.6% (n = 73/189). Clinical factors associated with reduced odds of survival included, hypothermia (odds ratio (OR) 0.18; CI 0.06-0.57; p = 0.01), bladder distension (OR 0.11; CI 0.02-0.59; p = 0.01), tachycardia (OR 0.97; CI 0.94-0.99; p = 0.04) and serum creatine kinase activity >100,000 IU/L (OR 0.17; CI 0.04-0.68; p = 0.01) in the univariable analysis as well as recumbency. The latter was the only sign retained in multivariable analysis (OR = 0.19; CI 0.06-0.62; p = 0.006). Administration of vitamins during the disease was associated with survival (OR 3.75; CI 1.21-11.57; p = 0.02). MAIN LIMITATIONS: Reporting cases to the atypical myopathy alert group is voluntary; therefore, under-reporting will result in underestimation of AM cases; furthermore, direct owner-reporting could have introduced misdiagnosis bias. CONCLUSION: Some areas of the UK reported AM cases more commonly. Clinical signs such as recumbency, rectal temperature, distended bladder and serum CK activity might be useful prognostic indicators though should be considered in the context of the clinical picture. Treatment with vitamins increases survival. This article is protected by copyright. All rights reserved. [less ▲]

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See detailL'évolution des charpentes métalliques en Belgique pendant le dernier quart de siècle (1932-1957)
Campus, Ferdinand ULiege

in Acier = Stahl = Steel (2017), 22(6), 257-264

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See detailAllelic variation in TLR4 is linked to resistance to Salmonella Enteritidis infection in chickens.
Li, Peng; Wang, Huihua; Zhao, Xingwang et al

in Poultry Science (2017)

Salmonella Enteritidis (SE) is a foodborne pathogen that negatively affects both animal and human health. Polymorphisms of the TLR4 gene may affect recognition by Toll-like receptor 4 (TLR4) of bacterial ... [more ▼]

Salmonella Enteritidis (SE) is a foodborne pathogen that negatively affects both animal and human health. Polymorphisms of the TLR4 gene may affect recognition by Toll-like receptor 4 (TLR4) of bacterial lipopolysaccharide (LPS), leading to differences in host resistance to pathogenic infections. The present study has investigated polymorphic loci of chicken TLR4 (ChTLR4) in ten chicken breeds, electrostatic potentials of mutant structures of TLR4, and a linkage analysis between allelic variation and survival ratio to infection with SE in specific-pathogen-free (SPF) White Leghorns. A total of 19 Single Nucleotide Polymorphisms (SNPs), of which 10 were novel, were found in chicken breeds. Seven newly identified amino acid variants (C68G, G674A, G782A, A896T, T959G, T986A, and A1104C) and previously reported important mutations (G247A, G1028A, C1147T, and A1832G) were demonstrated in the extracellular domain of the ChTLR4 gene. Significant changes in surface electrostatic potential of the ectodomain of TLR4, built by homology modeling, were observed at the Glu83Lys (G247A), Arg298Ser (A896T), Ser368Arg (A1104C), and Gln611Arg (A1832G) substitutions. Linkage analysis showed that one polymorphic locus G247A of TLR4 gene, common in all breeds examined, was significantly associated with increased resistance to SE in SPF White Leghorns chicks (log-rank P-value = 0.04). The genotypes from A1832G SNPs did not show statistically significant survival differences. This study has provided the first direct evidence that G247A substitution in ChTLR4 is associated with increased resistance to Salmonella Enteritidis. [less ▲]

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See detailDonnées nouvelles sur quelques espèces minérales de Haut-le-Wastia (Province de Namur, Belgique)
Blondieau, M; Puccio, S; Compère, Philippe ULiege et al

in Bulletin de la Société Royale des Sciences de Liège (2017), 86

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See detailAu coeur de la protection "multi-niveaux" et du dialogue juridictionnel : la "dématérialisation" des droits fondamentaux comme clé de lecture du raisonnement actuel dans le domaine des droits fondamentaux
Rosoux, Géraldine ULiege

in Fundamentos (2017), 9

L'article examine les différents raisonnements suivis par la Cour européenne des droits de l'homme, la Cour de justice de l'Union européenne et le juge constitutionnel belge, pour faire face à la ... [more ▼]

L'article examine les différents raisonnements suivis par la Cour européenne des droits de l'homme, la Cour de justice de l'Union européenne et le juge constitutionnel belge, pour faire face à la protection "multi-niveaux" des droits fondamentaux. [less ▲]

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See detailValidation of the SarQoL, a specific health-related quality of life questionnaire for Sarcopenia
Beaudart, Charlotte ULiege; Biver, Emmanuel; Reginster, Jean-Yves et al

in Journal of cachexia, sarcopenia and muscle (2017), 8(2), 238-44

Background A specific self-administrated health-related quality of life questionnaire for sarcopenia, the Sarcopenia and Quality Of Life (SarQoL®), has been recently developed. This questionnaire is ... [more ▼]

Background A specific self-administrated health-related quality of life questionnaire for sarcopenia, the Sarcopenia and Quality Of Life (SarQoL®), has been recently developed. This questionnaire is composed of 55 items translated into 22 questions and organized into seven domains of quality of life. The objective of the present work is to evaluate the psychometric properties (discriminative power, validity, reliability, floor and ceiling effects) of the SarQoL® questionnaire. Methods Sarcopenic subjects were recruited in an outpatient clinic in Liège, Belgium and were diagnosed according to the algorithm developed by the European Working Group on Sarcopenia in Older People. We compared the score of the SarQoL® between sarcopenic and non-sarcopenic subjects using a logistic regression after adjustment for potential confounding variables. Internal consistency reliability was determined using Cronbach’s alpha coefficient; construct validity was assessed using convergent and divergent validities. Test–retest reliability was verified after a two-week interval using the intra-class correlation coefficient (ICC). At last, floor and ceiling effects were also tested. Results A total of 296 subjects with a median age of 73.3 (68.9–78.6) years were recruited for this study. Among them, 43 were diagnosed sarcopenic. After adjustment for potential confounding factors, the total score and the scores of the different dimensions of the SarQoL® questionnaire were significantly lower for sarcopenic than for non-sarcopenic subjects (54.7 (45.9– 66.3) for sarcopenic vs. 67.8 (57.3 – 79.0) for non sarcopenic, OR 0.93 (95%CI 0.90–0.96)). Regarding internal consistency, the Cronbach’s alpha coefficient was 0.87. The SarQoL® questionnaire data showed good correlation with some domains of the Short-Form 36 (SF-36) and the EuroQoL 5-dimension (EQ-5D) questionnaires and with the mobility test. An excellent agreement between the test and the retest was found with an ICC of 0.91 (95% CI 0.82–0.95). At last, neither floor nor ceiling effects were detected. Conclusions The SarQoL® questionnaire is valid, consistent, and reliable and can therefore be recommended for clinical and research purposes. However, its sensitivity to change needs to be assessed in future longitudinal studies. [less ▲]

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See detailAccessibility and characteristics of memories of the future
Jeunehomme, Olivier ULiege; D'Argembeau, Arnaud ULiege

in Memory (2017), 25

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See detailGenetic structure of Lima bean (Phaseolus lunatus L.) landraces grown in the Mayan area
Camacho-Pérez, Luciana; Martínez-Castillo, Jaime; Mikangos-Cortés, Javier O. et al

in Genetic Resources and Crop Evolution (2017)

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See detailDonation d’assurance-vie en Région flamande: analyse de Vlabel et confirmation décrétale
Gustin, Manuel ULiege

in Revue de Planification Patrimoniale Belge et Internationale (2017)

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See detailLes « cavaliers budgétaires » sont-ils éphémères ? Une controverse qui perdure (note sous C.C., arrêt n° 58/2016 du 28 avril 2016)
Miny, Xavier ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (3), 110-117

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions ... [more ▼]

L’affaire relative à la réglementation wallonne du financement du vote électronique a été l’occasion, pour la Cour constitutionnelle, de revenir dans son arrêt n° 58/2016 du 28 avril 2016 sur les notions de budget et de cavalier budgétaire, ainsi que sur la durée de vie de ce genre controversé de dispositions et sur la compétence d’avis du Conseil d’État en la matière. Confrontée pour la première fois à certaines problématiques qu’engendrent les cavaliers budgétaires, la Cour constitutionnelle s’est néanmoins refusée à trancher l’ensemble des débats. [less ▲]

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See detailNew crystallographic data and formula revision of phuralumite, Al2[(UO2)3(PO4)2O(OH)](OH)3(H2O)9
Dal Bo, Fabrice ULiege; Hatert, Frédéric ULiege; Philippo, S

in Journal of Geosciences (2017), 62

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See detailThe Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation.
Chevigne, Andy; Campizi, Vincenzo; Szpakowska, Martyna et al

in International Journal of Molecular Sciences (2017), 18(5),

The major house dust mite allergen, Der p 1, is a papain-like cysteine protease expressed as an inactive precursor, proDer p 1, carrying an N-terminal propeptide with a unique structure. The maturation of ... [more ▼]

The major house dust mite allergen, Der p 1, is a papain-like cysteine protease expressed as an inactive precursor, proDer p 1, carrying an N-terminal propeptide with a unique structure. The maturation of the zymogen into an enzymatically-active form of Der p 1 is a multistep autocatalytic process initiated under acidic conditions through conformational changes of the propeptide, leading to the loss of its inhibitory ability and its subsequent gradual cleavage. The aims of this study were to characterize the residues present in the Der p 1 propeptide involved in the initiation of the zymogen maturation process, but also to assess the impact of acidic pH on the propeptide structure, the activity of Der p 1 and the fate of the propeptide. Using various complementary enzymatic and structural approaches, we demonstrated that a structural triad K17p-D51p-Y19p within the N-terminal domain of the propeptide is essential for its stabilization and the sensing of pH changes. Particularly, the protonation of D51p under acidic conditions unfolds the propeptide through disruption of the K17p-D51p salt bridge, reduces its inhibition capacity and unmasks the buried residues K17p and Y19p constituting the first maturation cleavage site of the zymogen. Our results also evidenced that this triad acts in a cooperative manner with other propeptide pH-responsive elements, including residues E56p and E80p, to promote the propeptide unfolding and/or to facilitate its proteolysis. Furthermore, we showed that acidic conditions modify Der p 1 proteolytic specificity and confirmed that the formation of the first intermediate represents the limiting step of the in vitro Der p 1 maturation process. Altogether, our results provide new insights into the early events of the mechanism of proDer p 1 maturation and identify a unique structural triad acting as a stabilizing and a pH-sensing regulatory element. [less ▲]

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See detailLaBGen: A method based on motion detection for generating the background of a scene
Laugraud, Benjamin ULiege; Pierard, Sébastien ULiege; Van Droogenbroeck, Marc ULiege

in Pattern Recognition Letters (2017), 96

Given a video sequence acquired with a fixed camera, the generation of the stationary background of the scene is a challenging problem which aims at computing a reference image for a motionless background ... [more ▼]

Given a video sequence acquired with a fixed camera, the generation of the stationary background of the scene is a challenging problem which aims at computing a reference image for a motionless background. For that purpose, we developed our method named LaBGen, which emerged as the best one during the Scene Background Modeling and Initialization (SBMI) workshop organized in 2015, and the IEEE Scene Background Modeling Contest (SBMC) organized in 2016. LaBGen combines a pixel-wise temporal median filter and a patch selection mechanism based on motion detection. To detect motion, a background subtraction algorithm decides, for each frame, which pixels belong to the background. In this paper, we describe the LaBGen method extensively, evaluate it on the SBI 2016 dataset and compare its performance with other background generation methods. We also study its computational complexity, the performance sensitivity with respect to its parameters, and the stability of the predicted background image over time with respect to the chosen background subtraction algorithm. We provide an open source C++ implementation at http://www.telecom.ulg.ac.be/labgen. [less ▲]

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See detailCrossing the dividing surface of transition state theory. IV. Dynamical regularity and dimensionality reduction as as key features of reactive trajectories
Lorquet, Jean-Claude ULiege

in The Journal of Chemical Physics (2017), 146

The atom-diatom interaction is studied by classical mechanics using Jacobi coordinates (R, r, θ). Reactivity criteria that go beyond the simple requirement of transition state theory (i.e., PR* > 0) are ... [more ▼]

The atom-diatom interaction is studied by classical mechanics using Jacobi coordinates (R, r, θ). Reactivity criteria that go beyond the simple requirement of transition state theory (i.e., PR* > 0) are derived in terms of specific initial conditions. Trajectories that exactly fulfill these conditions cross the conventional dividing surface used in transition state theory (i.e., the plane in configuration space passing through a saddle point of the potential energy surface and perpendicular to the reaction coordinate) only once. Furthermore, they are observed to be strikingly similar and to form a tightly-packed bundle of perfectly collimated trajectories in the two-dimensional (R, r) configuration space, although their angular motion is highly specific for each one. Particular attention is paid to symmetrical transition states (i.e., either collinear or T-shaped with C2v symmetry) for which decoupling between angular and radial coordinates is observed, as a result of selection rules that reduce to zero Coriolis couplings between modes that belong to different irreducible representations. Liapunov exponents are equal to zero and Hamilton's characteristic function is planar in that part of configuration space that is visited by reactive trajectories. Detailed consideration is given to the concept of average reactive trajectory, which starts right from the saddle point and which is shown to be free of curvature-induced Coriolis coupling. The reaction path Hamiltonian model, together with a symmetry-based separation of the angular degree of freedom, provide an appropriate framework that leads to the formulation of an effective two-dimensional Hamiltonian. The success of the adiabatic approximation in this model is due to the symmetry of the transition state, not to a separation of time scales. Adjacent trajectories, i.e., those that do not exactly fulfill the reactivity conditions have similar characteristics, but the quality of the approximation is lower. At higher energies, these characteristics persist, but to a lesser degree. Recrossings of the dividing surface then become much more frequent and the phase space volume of initial conditions that generate recrossing-free trajectories decreases. Altogether, one ends up with an additional illustration of the concept of reactive cylinder (or conduit) in phase space that reactive trajectories must follow. Reactivity is associated with dynamical regularity and dimensionality reduction, whatever the shape of the potential energy surface, no matter how strong its anharmonicity, and whatever the curvature of its reaction path. Both simplifying features persist during the entire reactive process, up to complete separation of fragments. The ergodicity assumption commonly assumed in statistical theories is inappropriate for reactive trajectories. [less ▲]

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See detailLes conceptions des futurs enseignants du secondaire en matière d’évaluation: entre un accord de principe et une vision limitée de l’évaluation formative
Fagnant, Annick ULiege; Goffin, Christelle ULiege

in Mesure et Evaluation en Education (2017), 40(1), 1-32

S’appuyant sur un questionnaire soumis à l’entrée en formation initiale, l’étude cherche à cerner la façon dont les futurs enseignants du secondaire perçoivent les liens entre évaluation et apprentissage ... [more ▼]

S’appuyant sur un questionnaire soumis à l’entrée en formation initiale, l’étude cherche à cerner la façon dont les futurs enseignants du secondaire perçoivent les liens entre évaluation et apprentissage. Elle s’intéresse aux différentes fonctions de l’évaluation, aux différentes formes d’évaluation formative auxquelles les futurs enseignants font face dans leur parcours scolaire et à la façon dont ils peuvent imaginer des modalités d’évaluation variées. Alors que les résultats des questionnaires fermés montrent que les participants soutiennent une vision élargie de l’évaluation formative, les questions ouvertes témoignent quant à elles d’une vision étroite dans laquelle le versant régulation n’est pas suffisamment présent et où les élèves semblent peu impliqués. Les expériences vécues par les futurs enseignants au cours de leur scolarité semblent limitées et ils imaginent difficilement qu’il soit possible d’intégrer pleinement l’évaluation aux situations d’apprentissage. [less ▲]

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See detailStereotype contrast effect on neuropsychological assessment of contact-sport players: The moderating role of locus of control
Fresson, Megan ULiege; Dardenne, Benoît ULiege; Geurten, Marie ULiege et al

in Journal of Clinical and Experimental Neuropsychology (2017)

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See detailThe right dorsal premotor mosaic: organization, functions, and connectivity
Genon, Sarah ULiege; Li, Hai; Fan, Lingzhong et al

in Cerebral Cortex (2017), 27(3), 2095-2110

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a ... [more ▼]

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our CBP results to parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography,. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into five distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found (i) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory (ii) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and (iii) a caudal subregion closely integrated with the motor system. Additionally, we found (iv) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and (v) a ventral subregion, whose functional profile fits the concept of an eye-movement related field. In conclusion, right PMd may be considered as a functional mosaic formed by five subregions. [less ▲]

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See detailTuned protection of aphids by ants against a predatory hoverfly
Detrain, Claire; Fichaux; Verheggen, François ULiege

in Ecological Entomology (2017)

1. Aphid-tending ants that feed on honeydew have evolved strategies against aphidophagous insects and tune their aggressive behaviour according to the level of danger for their trophobionts. Here we ... [more ▼]

1. Aphid-tending ants that feed on honeydew have evolved strategies against aphidophagous insects and tune their aggressive behaviour according to the level of danger for their trophobionts. Here we investigate how Lasius niger Linnaeus (Hymenoptera: Formicidae) ants react to different instars of Episyrphus balteatus De Geer (Diptera: Syrphidae) hoverflies which vary in their voracity and defensive abilities. 2. During pairwise encounters, early syrphid instars (eggs, L1, and L2 larvae) elicited lower aggression scores compared to third larval instars (L3), which was intensively bitten by ants. L3 tried to escape from ants by releasing a sticky and toxic secretion over biting ants that died or underwent severe morbidity. 3. In a standardised system including the host plant, aphid, tending ant, and hoverfly, the ability of ants to protect an Aphis fabae Scopoli (Hemiptera: Aphididae) colony was evaluated. Early E. balteatus instars placed onto the plant elicited no mobilisation of ants, which often removed the hoverfly successfully. Eggs and early instars appeared as the weak links for integrated pest management by hoverfly auxiliaries. 4. In contrast, L3 induced the number of ant patrollers to increase at a local scale without any further recruitment from inside the ant nest. L3 syrphids were quite efficient at gluing ants with defensive secretions and at resisting to removal attempts by ants. 5. While supporting the assumption that ants tune their defensive response to the aphidophagous predator, the present results also showed a lack of efficient protection of their trophobionts from the most voracious late syrphid instar. [less ▲]

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See detailComputation of GPS P1–P2 Differential Code Biases with JASON-2
Wautelet, Gilles ULiege; Loyer, Sylvain; Mercier, Flavien et al

in GPS Solutions (2017)

GPS Differential Code Biases (DCBs) computation is usually based on ground networks of permanent stations. The drawback of the classical methods is the need for the ionospheric delay so that any error in ... [more ▼]

GPS Differential Code Biases (DCBs) computation is usually based on ground networks of permanent stations. The drawback of the classical methods is the need for the ionospheric delay so that any error in this quantity will map into the solution. Nowadays, many low-orbiting satellites are equipped with GPS receivers which are initially used for precise orbitography. Considering spacecrafts at an altitude above the ionosphere, the ionized contribution comes from the plasmasphere, which is less variable in time and space. Based on GPS data collected onboard JASON-2 spacecraft, we present a methodology which computes in the same adjustment the satellite and receiver DCBs in addition to the plasmaspheric vertical total electron content (VTEC) above the satellite, the average satellite bias being set to zero. Results show that GPS satellite DCB solutions are very close to those of the IGS analysis centers using ground measurements. However, the receiver DCB and VTEC are closely correlated, and their value remains sensitive to the choice of the plasmaspheric parametrization. [less ▲]

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See detailInto the Lead: How EJVES Became the Leading Journal in Vascular Surgery.
Bjorck, M.; Kolh, Philippe ULiege

in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2017), 54(3), 273-274

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See detailFenomenologische psychopathologie : Hedendaagse inbreng en uitdagingen van morgen
Englebert, Jérôme ULiege

in Neurone (2017), 22(9), 1-5

Dit artikel beschrijft de geschiedenis van de fenomenologische psychopathologie, die ondertussen honderd jaar bestaat, en vat de bijdrage van de fenomenologie aan de psychopathologie samen. Enerzijds gaat ... [more ▼]

Dit artikel beschrijft de geschiedenis van de fenomenologische psychopathologie, die ondertussen honderd jaar bestaat, en vat de bijdrage van de fenomenologie aan de psychopathologie samen. Enerzijds gaat dit artikel over een recente bijdrage die de fenomenologische psychopathologie heeft geleverd aan de kennis over een geestesziekte waar we niet omheen kunnen: schizofrenie. Anderzijds belichten we de uitdagingen, perspectieven en projecten die deze heroplevende discipline kennelijk met zich meebrengt. [less ▲]

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See detailSeasonal characterization of the nutrients state in Oualidia Lagoon (Moroccan Atlantic coast)
Damsiri, Zainab; Natij, L.; Khalil, Karima et al

in Journal of Materials and Environmental Science (2017), 8(1), 67-77

The nutrient cycle in Oualidia lagoon, on the Atlantic Moroccan coast, was studied at both spatial and temporal scales, covering spring and summer conditions. Water samples were collected bimonthly at ... [more ▼]

The nutrient cycle in Oualidia lagoon, on the Atlantic Moroccan coast, was studied at both spatial and temporal scales, covering spring and summer conditions. Water samples were collected bimonthly at high tide from March to August during years 2011 and 2012 at six stations distributed throughout the lagoon. The physico- chemistry (temperature, salinity, dissolved O2) and nutrient enrichment of the lagoon surface water were monitored. The average nutrient concentration of surface water were 14.4 μmol.l-1 and 28.1 μmol.l-1 for NH4+, 20.4 μmol.l-1 and 19.9 μmol.l-1 for PO43- and 3.7 μmol.l-1 and 7.6 μmol.l-1 for NO2- in 2011 and 2012, respectively. Strong seasonal differences of nutrient distribution at the different stations were noticed. Temperature, salinity and dissolved O2 were correlated with nutrient concentrations, all parameters showing low spatial (inter-station) variability. Hydrological conditions exert a major control on the nutrient cycling in the lagoon. Results of this study are important to increase the richness on the scientific knowledge of nutrient dynamics along the Moroccan Atlantic coast, particularly in the semi-enclosed lagoons that are important transitional systems. [less ▲]

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See detailMyocardial revascularization in patients with left main or multivessel coronary artery disease at high surgical risk: conventional wisdom versus risk prediction model.
Piccolo, Raffaele; Windecker, Stephan; Kolh, Philippe ULiege

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2017), 51(5), 949-951

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See detailAltered functional brain connectivity in patients with visually induced dizziness
Van Ombergen, Angelique; Heine, Lizette ULiege; Jillings, Steven et al

in NeuroImage (2017), 14

Background: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience ... [more ▼]

Background: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience dizziness, discomfort, disorientation and postural unsteadiness. The underlying pathophysiology of VID is still poorly understood. Objective: The aimof the current explorative study was to gain a first insight in the underlying neural aspects of VID. Methods:We included 10 VID patients and 10 healthymatched controls, all ofwhich underwent a resting state fMRI scan session. Changes in functional connectivitywere explored bymeans of the intrinsic connectivity contrast (ICC). Seed-based analysis was subsequently performed in visual and vestibular seeds. Results: We found a decreased functional connectivity in the right central operculum (superior temporal gyrus), as well as increased functional connectivity in the occipital pole in VID patients as compared to controls in a hypothesis-free analysis. A weaker functional connectivity between the thalamus and most of the right putamen was measured in VID patients in comparison to controls in a seed-based analysis. Furthermore, also by means of a seed-based analysis, a decreased functional connectivity between the visual associative area and the left parahippocampal gyrus was found in VID patients. Additionally,we found increased functional connectivity between thalamus and occipital and cerebellar areas in the VID patients, as well as between the associative visual cortex and both middle frontal gyrus and precuneus. Conclusions:We found alterations in the visual and vestibular cortical network in VID patients that could underlie the typical VID symptoms such as a worsening of their vestibular symptoms when being exposed to challenging visual stimuli. These preliminary findings provide the first insights into the underlying functional brain connectivity in VID patients. Future studies should extend these findings by employing larger sample sizes, by investigating specific task-based paradigms in these patients and by exploring the implications for treatment. [less ▲]

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See detailIntroduction de la section "Echos de la recherche"
Simons, Germain ULiege; Beckers, Jacqueline ULiege; De Croix, Séverine et al

in Didactiques en Pratique (2017), 3

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See detailLe medicament du mois BIPRESSIL(R) : Premiere association fixe bisoprolol et perindopril arginine.
GACH, Olivier ULiege; FALQUE, Bertrand ULiege; CANIVET, Antoine ULiege et al

in Revue Médicale de Liège (2017), 72(5), 260-265

In patients suffering from systemic arterial hypertension, coronary artery disease, or heart failure, beta-blockers and angiotensin-convertase enzyme inhibitors play a major therapeutic and preventive ... [more ▼]

In patients suffering from systemic arterial hypertension, coronary artery disease, or heart failure, beta-blockers and angiotensin-convertase enzyme inhibitors play a major therapeutic and preventive role. Coronary artery disease remains the leading cause of mortality in industrialized countries. Unless adapted preventive strategy, notably pharmacological interventions, cardiovascular events in these patients remain high. One reason for this relative failure is represented by non-adherence to treatment. A treatment consisting in an association in one pill of several different molecules should confer a higher treatment compliance and thus efficacy. This article describes the characteristics of the first available dual association between a cardioselective beta-blocker agent, bisoprolol, and an angiotensin-convertase enzyme inhibitor, perindopril arginine. [less ▲]

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See detailHaploidentical hematopoietic cell transplantation for adult acute myeloid leukemia: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Lee, Catherine J.; Savani, Bipin N.; Mohty, Mohamad et al

in Haematologica (2017), 102(11), 1810-1822

Allogeneic blood or marrow hematopoietic cell transplantation continues to be the most potent anti-leukemic treatment for adult patients with standard, high-risk, or chemo-refractory acute myeloid ... [more ▼]

Allogeneic blood or marrow hematopoietic cell transplantation continues to be the most potent anti-leukemic treatment for adult patients with standard, high-risk, or chemo-refractory acute myeloid leukemia. Until recently, this procedure was generally limited to those recipients who had an available matched-sibling donor or matched-unrelated donor. Technical advances in graft cell processing and manipulation, control of bidirectional T cell alloreactivity, graft-versus-host disease prophylaxis, and other supportive measures in haploidentical transplantation now enable nearly all patients with acute myeloid leukemia to benefit from the graft-versus-leukemia effect with substantial reduction in procedure-related mortality. Over recent years, haploidentical donors have been increasingly adopted as a valid donor source in allogeneic hematopoietic cell transplantation for acute myeloid leukemia in the absence of an HLA-matched donor. Among centers of the European Society for Blood and Marrow Transplantation, the use of haploidentical related donor transplantation has increased by 250% since 2010, and 291% since 2005. On behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize recent utilization trends in haploidentical transplantation for acute myeloid leukemia and describe the transformative changes in haploidentical hematopoietic cell transplantation techniques over the past decade, which have led to the current widespread use of this procedure. Furthermore, we review the efficacy of haploidentical hematopoietic cell transplantation for acute myeloid leukemia from available studies, including preliminary comparative studies, and bring attention to remaining unanswered questions and directions for future research. We conclude this report with our recommendations for the role of haploidentical hematopoietic cell transplantation in acute myeloid leukemia. [less ▲]

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See detailMRI follow-up is unnecessary in patients with macroprolactinomas and long-term normal prolactin levels on dopamine agonist treatment.
Eroukhmanoff, J.; Tejedor, I.; Potorac, Iulia ULiege et al

in European Journal of Endocrinology (2017), 176(3), 323-328

OBJECTIVE: Both antitumor and antisecretory efficacies of dopamine agonists (DA) make them the first-line treatment of macroprolactinomas. However, there is no guideline for MRI follow-up once prolactin ... [more ▼]

OBJECTIVE: Both antitumor and antisecretory efficacies of dopamine agonists (DA) make them the first-line treatment of macroprolactinomas. However, there is no guideline for MRI follow-up once prolactin is controlled. The aim of our study was to determine whether a regular MRI follow-up was necessary in patients with long-term normal prolactin levels under DA. PATIENTS AND METHODS: We conducted a retrospective multicenter study (Marseille, Paris La Pitie Salpetriere and Nancy, France; Liege, Belgium) including patients with macroprolactinomas (largest diameter: >10 mm and baseline prolactin level: >100 ng/mL) treated by dopamine agonists, and regularly followed (pituitary MRI and prolactin levels) during at least 48 months once normal prolactin level was obtained. RESULTS: In total, 115 patients were included (63 men and 52 women; mean age at diagnosis: 36.3 years). Mean baseline prolactin level was 2224 +/- 6839 ng/mL. No significant increase of tumor volume was observed during the follow-up. Of the 21 patients (18%) who presented asymptomatic hemorrhagic changes of the macroprolactinoma on MRI, 2 had a tumor increase (2 and 7 mm in the largest size). Both were treated by cabergoline (1 mg/week) with normal prolactin levels obtained for 6 and 24 months. For both patients, no further growth was observed on MRI during follow-up at the same dose of cabergoline. CONCLUSION: No significant increase of tumor size was observed in our patients with controlled prolactin levels on DA. MRI follow-up thus appears unnecessary in patients with biologically controlled macroprolactinomas. [less ▲]

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See detailEditorial - De la notion de <<bonne sante>> a des cas pathologiques exemplatifs.
Scheen, André ULiege

in Revue Médicale de Liège (2017), 72(7-8), 325-326

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See detailThe Clinical Use of Stress Echocardiography in Non-Ischaemic Heart Disease: Recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography
Lancellotti, Patrizio ULiege; Pellika, PA; Budts, W et al

in Journal of the American Society of Echocardiography (2017)

A unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of ... [more ▼]

A unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of myocardial function and haemodynamics under physiological or pharmacological conditions. Due to its diagnostic and prognostic value, SE has become widely implemented to assess various conditions other than ischaemic heart disease. It has thus become essential to establish guidance for its applications and performance in the area of non-ischaemic heart disease. This paper summarizes these recommendations. [less ▲]

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See detail1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases
Sevaille, Laurent; Gavara, Laurent; Bebrone, Carine et al

in ChemMedChem (2017), 12

Metallo-β-lactamases (MBLs) cause resistance of Gram-negative bacteria to β-lactam antibiotics and are of serious concern, because they can inactivate the last-resort carbapenems and because MBL ... [more ▼]

Metallo-β-lactamases (MBLs) cause resistance of Gram-negative bacteria to β-lactam antibiotics and are of serious concern, because they can inactivate the last-resort carbapenems and because MBL inhibitors of clinical value are still lacking. We previously identified the original binding mode of 4-amino-2,4-dihydro-5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione (compound IIIA) within the dizinc active site of the L1 MBL. Herein we present the crystallographic structure of a complex of L1 with the corresponding non-amino compound IIIB (1,2-dihydro-5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione). Unexpectedly, the binding mode of IIIB was similar but reverse to that of IIIA. The 3 D structures suggested that the triazole-thione scaffold was suitable to bind to the catalytic site of dizinc metalloenzymes. On the basis of these results, we synthesized 54 analogues of IIIA or IIIB. Nineteen showed IC50 values in the micromolar range toward at least one of five representative MBLs (i.e., L1, VIM-4, VIM-2, NDM-1, and IMP-1). Five of these exhibited a significant inhibition of at least four enzymes, including NDM-1, VIM-2, and IMP-1. Active compounds mainly featured either halogen or bulky bicyclic aryl substituents. Finally, some compounds were also tested on several microbial dinuclear zinc-dependent hydrolases belonging to the MBL-fold superfamily (i.e., endonucleases and glyoxalase II) to explore their activity toward structurally similar but functionally distinct enzymes. Whereas the bacterial tRNases were not inhibited, the best IC50 values toward plasmodial glyoxalase II were in the 10 μm range. [less ▲]

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See detailThe three-dimensional rectangular Multiple Bin Size Bin Packing Problem with transportation constraints: A case study in the field of air transportation
Paquay, Célia ULiege

in 4OR : Quarterly Journal of the Belgian, French and Italian Operations Research Societies (2017)

Ph. D Thesis summary see other reference on ORBI

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See detailHistologically Proven Bronchial Neuroendocrine Tumors in MEN1: A GTE 51-Case Cohort Study.
Lecomte, Pierre ULiege; Binquet, C.; Le Bras, M. et al

in World Journal of Surgery (2017)

OBJECTIVE: To evaluate the natural history of MEN1-related bronchial endocrine tumors (br-NETs) and to determine their histological characteristics, survival and causes of death. br-NETs frequency ranges ... [more ▼]

OBJECTIVE: To evaluate the natural history of MEN1-related bronchial endocrine tumors (br-NETs) and to determine their histological characteristics, survival and causes of death. br-NETs frequency ranges from 3 to 13% and may reach 32% depending on the number of patients evaluated and on the criteria required for diagnosis. METHODS: The 1023-patient series of symptomatic MEN1 patients followed up in a median of 48.7 [35.5-59.6] years by the Groupe d'etude des Tumeurs Endocrines was analyzed using time-to-event techniques. RESULTS: br-NETs were found in 51 patients (4.8%, [95% CI 3.6-6.2%]) and were discovered by imaging in 86% of cases (CT scan, Octreoscan, Chest X-ray, MRI). Median age at diagnosis was 45 years [28-66]. Histological examination showed 27 (53%) typical carcinoids (TC), 16 (31%) atypical carcinoids (AC), 2 (4%) large cell neuroendocrine carcinomas (LCNEC), 3(6%) small cell neuroendocrine carcinomas (SCLC), 3(6%) TC associated with AC. Overall survival was not different from the rest of the cohort (HR 0.29, [95% CI 0.02-5.14]). AC tended to have a worse prognosis than TC (p = 0.08). Seven deaths were directly related to br-NETs (three AC, three SCLC and one LCNEC). Patients who underwent surgery survived longer (p = 10-4) and were metastasis free, while 8 of 14 non-operated patients were metastatic. There were no operative deaths. CONCLUSIONS: Around 5% of MEN1 patients develop br-NETs. br-NETs do not decrease overall survival in MEN1 patients, but poorly differentiated and aggressive br-NETs can cause death. br-NETs must be screened carefully. A biopsy is essential to operate on patients in time. [less ▲]

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See detailQuantitative Agreement between Electron-Optical Phase Images of $WSe_2$ and Simulations Based on Electrostatic Potentials that Include Bonding Effects
Borghardt, S.; Winkler, F.; Zanolli, Zeila ULiege et al

in Physical Review Letters (2017), 118

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See detailBiomarkers Predicting Bone Turnover in the Setting of CKD.
Evenepoel, Pieter; Cavalier, Etienne ULiege; D'Haese, Patrick C.

in Current Osteoporosis Reports (2017)

PURPOSE OF THE REVIEW: Impaired bone quality contributes to the increased fracture risk in chronic kidney disease patients. Both low and high turnover bone disease may compromise bone quality. The ... [more ▼]

PURPOSE OF THE REVIEW: Impaired bone quality contributes to the increased fracture risk in chronic kidney disease patients. Both low and high turnover bone disease may compromise bone quality. The question arises whether bone biomarkers may be additive or replace bone histormorphometry for diagnosing the extremes of bone turnover. RECENT FINDINGS: Studies exploring the performance of established and emerging bone biomarkers against histomorphometric assessment of bone turnover are limited and overall yield inconclusive results as to their diagnostic utility. Bone biomarkers, although promising, currently fail to meet the needed diagnostic accuracy to replace bone histomorphometry and thus are not yet ready for clinical use. Bone biomarkers have not only several advantages, but also important limitations such as high biological variability, retention with kidney disease, preanalytical issues, and interassay variability. These important issues must be considered when developing and evaluating bone biomarkers. There is an urgent need for harmonization and standardization of available assays and additional bone biopsy studies. [less ▲]

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See detailIntegration of Gene Expression and Methylation to unravel Biological Networks in Glioblastoma Patients
Bessonov, Kyrylo ULiege; Gadaleta, Francesco; Van Steen, Kristel ULiege

in Genetic Epidemiology (2017)

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information ... [more ▼]

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information. In this work we describe Regression2Net, a computational approach that is able to integrate gene expression and genomic or methylome data in two steps. First, penalized regressions are used to build Expression-Expression (EEnet) and Expression-Genome or –Methylome (EMnet) networks. Second, network theory is used to highlight important communities of genes. When applying our approach Regression2Net to gene expression and methylation profiles for individuals with glioblastoma multiforme, we identified respectively 284 and 447 potentially interesting genes in relation to glioblastoma pathology. These genes showed at least one connection in the integrated networks ANDnet and XORnet derived from aforementioned EEnet and EMnet networks. Whereas the edges in ANDnet occur in both EEnet and EMnet, the edges in XORnet occur in EMnet but not in EEnet. In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response and several cancer types. Importantly, we observed significant over-representation of cancer related pathways including glioma, especially in the XORnet network, suggesting a non-ignorable role of methylation in glioblastoma multiforma. In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. [less ▲]

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See detailProductivity and temperature as drivers of seasonal and spatial variations of dissolved methane in the Southern Bight of the North Sea
Borges, Alberto ULiege; Speeckaert, Gaëlle ULiege; Champenois, Willy ULiege et al

in Ecosystems (2017), doi:10.1007/s10021-017-0171-7

Dissolved CH4 concentrations in the Belgian coastal zone (North Sea) ranged between 670 nmol L-1 near-shore and 4 nmol L-1 off-shore. Spatial variations of CH4 were related to sediment organic matter (OM ... [more ▼]

Dissolved CH4 concentrations in the Belgian coastal zone (North Sea) ranged between 670 nmol L-1 near-shore and 4 nmol L-1 off-shore. Spatial variations of CH4 were related to sediment organic matter (OM) content and gassy sediments. In near-shore stations with fine sand or muddy sediments, the CH4 seasonal cycle followed water temperature, suggesting methanogenesis control by temperature in these OM rich sediments. In off-shore stations with permeable sediments, the CH4 seasonal cycle showed a yearly peak following the Chlorophyll-a spring peak, suggesting that in these OM poor sediments, methanogenesis depended on freshly produced OM delivery. This does not exclude the possibility that some CH4 might originate from dimethylsulfide (DMS) or dimethylsulfoniopropionate (DMSP) or methylphosphonate transformations in the most off-shore stations. Yet, the average seasonal CH4 cycle was unrelated to those of DMS(P), very abundant during the Phaeocystis bloom. The annual average CH4 emission was 126 mmol m-2 yr-1 in the most near-shore stations (~4 km from the coast) and 28 mmol m-2 yr-1 in the most off-shore stations (~23 km from the coast), 1,260 to 280 times higher than the open ocean average value (0.1 mmol m-2 yr-1). The strong control of CH4 by sediment OM content and by temperature suggests that marine coastal CH4 emissions, in particular in shallow areas, should respond to future eutrophication and warming of climate. This is supported by the comparison of CH4 concentrations at five stations obtained in March 1990 and 2016, showing a decreasing trend consistent with alleviation of eutrophication in the area. [less ▲]

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See detailRationalising vitamin B6 biofortification in crop plants.
Fudge, Jared; Mangel, Nathalie; Gruissem, Wilhelm et al

in Current Opinion in Biotechnology (2017), 44

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are ... [more ▼]

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are established in all kingdoms. Human vitamin B6 dietary insufficiency or genetic defects in B6 vitamer interconversion result in various neurological and inflammatory pathologies with several populations at-risk or marginal for vitamin B6 status. Three (rice, wheat and cassava) of the world's top five staple crops do not meet the recommended dietary allowance for vitamin B6, when consumed as a major proportion of the diet. In addition, controlled enhancement of the appropriate B6 vitamer in crops has the potential to confer stress resistance. Thus, crop biofortification strategies represent an opportunity to reduce the risk of deficiency in populations with limited diet diversity and quality, as well as improving stress tolerance. [less ▲]

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See detailModulation of piglets’ microbiota: differential effects by a high wheat bran maternal diet during gestation and lactation
Leblois, Julie ULiege; Massart, Sébastien ULiege; Li, Bing et al

in Scientific Reports (2017)

Reaching a beneficial intestinal microbiota early in life is desirable for piglets, as microbiota will impact their future health. One strategy to achieve this is the addition of prebiotics to sows’ diet ... [more ▼]

Reaching a beneficial intestinal microbiota early in life is desirable for piglets, as microbiota will impact their future health. One strategy to achieve this is the addition of prebiotics to sows’ diet, as their microbiota will be transferred. Transmission of microbiota to the offspring occurs at birth and during lactation but a transfer might also occur during gestation. The objectives of this study were to determine whether and when (before and/or after birth) a maternal transfer of the microbiota occurs, and to observe the impact of wheat bran (WB) in sows’ diet on their faecal microbiota, their offspring’s microbiota and fermentation profile. Sequencing was performed on DNA extracted from umbilical cord blood, meconium, sows’ faeces and piglets’ colon content. Short-chain fatty acid production was determined in piglets’ distal gut. Different bacteria (mostly Proteobacteria, followed by Firmicutes) were found in the umbilical cord blood, suggesting a maternal transfer occurring already during gestation. Less butyrate was produced in the caecum of WB piglets and a lower concentration of valerate was observed in all intestinal parts of WB piglets. Maternal wheat bran supplementation affected microbiota of sows and piglets differently. [less ▲]

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See detailLoss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.
Laguesse, Sophie; Close, Pierre ULiege; Van Hees, Laura ULiege et al

in Frontiers in Cellular Neuroscience (2017), 11

The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective ... [more ▼]

The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective alpha-tubulin acetylation. However, this complex is already expressed by cortical progenitors where it may regulate the early steps of migration by targeting additional proteins. Here we report that connexin-43 (Cx43), which is strongly expressed by cortical progenitors and whose depletion impairs projection neuron migration, requires Elongator expression for its proper acetylation. Indeed, we show that Cx43 acetylation is reduced in the cortex of Elp3cKO embryos, as well as in a neuroblastoma cell line depleted of Elp1 expression, suggesting that Cx43 acetylation requires Elongator in different cellular contexts. Moreover, we show that histones deacetylase 6 (HDAC6) is a deacetylase of Cx43. Finally, we report that acetylation of Cx43 regulates its membrane distribution in apical progenitors of the cerebral cortex. [less ▲]

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See detail"Sarebbe riuscita insieme un’opera molto onorata" : per Perino del Vaga a Pisa.
Geremicca, Antonio ULiege

in Studi di Storia dell'arte (2017)

There are still many questions concerning Perino del Vaga’s career in the early 1530s, especially in regard of his crucial decision to leave Genoa for a new destination. Before going back to Rome and ... [more ▼]

There are still many questions concerning Perino del Vaga’s career in the early 1530s, especially in regard of his crucial decision to leave Genoa for a new destination. Before going back to Rome and becoming the Farnese court's main painter (1537-1538), Perino evaluated the opportunity to live in Tuscany, where he also bought a house (1534). The aim of this article is to rebuild the activity of the artist in Pisa that apparently has been more intense than previously thought by studies. Perino stayed in the city at least in three different occasions, between 1531 and 1537, to participate at the new decoration of the Cathedral, that unfortunately was left incomplete and almost nothing remained nowadays. In addition to this, Vasari wrote a contradictory description of it in the Lives (1568). The article will focus on Perino’s graphic production during that period that might suggest how he was preparing his projects for the Cathedral. [less ▲]

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See detailRoad and intermodal transport performance: the impact of operational costs and air pollution external costs
Mostert, Martine ULiege; Caris, An; Limbourg, Sabine ULiege

in Research in Transportation Business & Management (2017)

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that ... [more ▼]

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that are not necessarily taken into account in public transportation policies and in private transportation decisions of companies and individuals. This leads to inefficient transportation systems where the social equilibrium is not reached. Intermodal transport is promoted by the European Commission to reduce these negative externalities. The objective of this paper is to analyze at a strategic level the effect on modal split between road, intermodal rail and intermodal inland waterway transport of several economic or environmental policies. An intermodal allocation model is applied to the Belgian case in order to identify the modal split changes between the single minimization of costs (operational or health-related external) and the introduction of additional road taxes. [less ▲]

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See detailInvited review: Large-scale indirect measurements for enteric methane emissions in dairy cattle: A review of proxies and their potential for use in management and breeding decisions
Negussie, E.; Haas, Y. De; Dehareng, F. et al

in Journal of Dairy Science (2017), 100(4), 2433-2453

Efforts to reduce the carbon footprint of milk production through selection and management of low-emitting cows require accurate and large-scale measurements of methane (CH4) emissions from individual ... [more ▼]

Efforts to reduce the carbon footprint of milk production through selection and management of low-emitting cows require accurate and large-scale measurements of methane (CH4) emissions from individual cows. Several techniques have been developed to measure CH4 in a research setting but most are not suitable for large-scale recording on farm. Several groups have explored proxies (i.e., indicators or indirect traits) for CH4; ideally these should be accurate, inexpensive, and amenable to being recorded individually on a large scale. This review (1) systematically describes the biological basis of current potential CH4 proxies for dairy cattle; (2) assesses the accuracy and predictive power of single proxies and determines the added value of combining proxies; (3) provides a critical evaluation of the relative merit of the main proxies in terms of their simplicity, cost, accuracy, invasiveness, and throughput; and (4) discusses their suitability as selection traits. The proxies range from simple and low-cost measurements such as body weight and high-throughput milk mid-infrared spectroscopy (MIR) to more challenging measures such as rumen morphology, rumen metabolites, or microbiome profiling. Proxies based on rumen samples are generally poor to moderately accurate predictors of CH4, and are costly and difficult to measure routinely on-farm. Proxies related to body weight or milk yield and composition, on the other hand, are relatively simple, inexpensive, and high throughput, and are easier to implement in practice. In particular, milk MIR, along with covariates such as lactation stage, are a promising option for prediction of CH4 emission in dairy cows. No single proxy was found to accurately predict CH4, and combinations of 2 or more proxies are likely to be a better solution. Combining proxies can increase the accuracy of predictions by 15 to 35%, mainly because different proxies describe independent sources of variation in CH4 and one proxy can correct for shortcomings in the other(s). The most important applications of CH4 proxies are in dairy cattle management and breeding for lower environmental impact. When breeding for traits of lower environmental impact, single or multiple proxies can be used as indirect criteria for the breeding objective, but care should be taken to avoid unfavorable correlated responses. Finally, although combinations of proxies appear to provide the most accurate estimates of CH4, the greatest limitation today is the lack of robustness in their general applicability. Future efforts should therefore be directed toward developing combinations of proxies that are robust and applicable across diverse production systems and environments. [less ▲]

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See detailProteomic profile of aphids exposed to wheat with different contents of benzoxazinoids
Barrios–San Martín, Joceline; Bosquée, Emilie ULiege; Rubio-Melendez, Maria et al

in Physiological Entomology (2017), Accepted

Benzoxazinoids are key defence chemicals in cereals that are known to affect several aspects of aphid biology. However, little is known about how they affect aphid physiology. In this study, we report ... [more ▼]

Benzoxazinoids are key defence chemicals in cereals that are known to affect several aspects of aphid biology. However, little is known about how they affect aphid physiology. In this study, we report changes in the whole-body proteomic profiles of a DIMBOA-susceptible genotype of the grain aphid Sitobion avenae (F.) after being exposed to wheat cultivars containing contrasting levels of DIMBOA. The proteome was analysed after 14 (short term) and 28 days (long term) of rearing on these cultivars. Seventy-two proteins were differentially regulated among the treatments, and 49 were identified. Exposure to high-DIMBOA plants resulted in a higher number of proteins regulated long term. DIMBOA exposure in S. avenae initially generated greater cellular activities, mostly involving cytoskeleton function and possibly related to detoxification. This function appeared to be unimportant at long term and was eventually replaced by effects on metabolism function and homeostasis. Taken together, the result shows that aphids’ responses to the secondary plant compounds, such as DIMBOA, exhibit a temporal dynamic in the proteome, possibly helping aphids to overcome the effect of these toxic compounds. [less ▲]

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See detailMaternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years.
Robles, M; Gauthier, C; Mendoza García, Luis ULiege et al

in PLoS ONE (2017), 12(e0169295),

INTRODUCTION: Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of concentrates is linked to ... [more ▼]

INTRODUCTION: Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of concentrates is linked to alterations of metabolism and the development of osteochondrosis in foals. The aim of this study was to determine if broodmare diet during gestation affects metabolism, osteoarticular status and growth of yearlings overfed from 20 to 24 months of age and/or sexual maturity in prepubertal colts. MATERIAL AND METHODS: Twenty-four saddlebred mares were fed forage only (n = 12, group F) or cracked barley and forage (n = 12, group B) from mid-gestation until foaling. Colts were gelded at 12 months of age. Between 20 and 24 months of age, all yearlings were overfed (+140% of requirements) using an automatic concentrate feeder. Offspring were monitored for growth between 6 and 24 months of age, glucose homeostasis was evaluated via modified frequently sampled intra veinous glucose tolerance test (FSIGT) at 19 and 24 months of age and osteoarticular status was investigated using radiographic examinations at 24 months of age. The structure and function of testicles from prepubertal colts were analyzed using stereology and RT-qPCR. RESULTS: Post-weaning weight growth was not different between groups. Testicular maturation was delayed in F colts compared to B colts at 12 months of age. From 19 months of age, the cannon bone was wider in B vs F yearlings. F yearlings were more insulin resistant at 19 months compared to B yearlings but B yearlings were affected more severely by overnutrition with reduced insulin sensitivity. The osteoarticular status at 24 months of age was not different between groups. CONCLUSION: In conclusion, nutritional management of the pregnant broodmare and the growing foal may affect sexual maturity of colts and the metabolism of foals until 24 months of age. These effects may be deleterious for reproductive and sportive performances in older horses. [less ▲]

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See detailLabor Use and Management in Vietnamese Craft Villages: A Case Study in Tu Son Town, Bac Ninh Province
Nguyen Thi Hai Ninh, ULiege; Lebailly, Philippe ULiege

in Asian Research Journal of Business Management (2017), 4(4), 54-63

The findings of the research on 150 laborers in three craft villages show that 41.33 percent of labor are concentrated in the age group of 30-45, of these laborers men is accounted for over 57 percent ... [more ▼]

The findings of the research on 150 laborers in three craft villages show that 41.33 percent of labor are concentrated in the age group of 30-45, of these laborers men is accounted for over 57 percent, and only 26 percent are skilled labor. Most of the laborers are working in noisy and unsafe conditions, and less than 30% of them are equipped with labor protection equipment. Moreover, the prevailing salaries of laborers are from 3 to 5 million VND per month whereas the rate of labor contracted is very low (the highest is about 23% at Da Hoi), that makes labourers are less satisfied with work. In order to determine factors effecting laborer’s satisfaction with work, the authors use Exploratory Factor Analysis and the results show that Cronbach Alfa coefficient of each group is more than 0.6. That indicates the use of 30 observation variations belonging to 5 factors in the study is suitable. Additionally, logistic model reports that working conditions, income, welfare policies and gender have a statistically significant effect on job satisfaction of labourers. When the score of the importance of working condition increases 1 point, the probability of workers satisfy with their works increases 1.307 time. When the score of importance of income increases 1 point, the probability of satisfaction increases 1.494 time. When the score of importance of treatment policy increases 1 point, the probability of satisfaction increases 1.329 time. Therefore craft villages need to improve these factors in order to improve the efficiency of labour. [less ▲]

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See detailChemical Composition of Distilled Essential Oils and Hydrosols of Four Senegalese Citrus and Enantiomeric Characterization of Chiral Compounds
Ndiaye, El Hadji Barka; Gueye, Momar Talla; Ndiaye, Ibrahima et al

in Journal of Essential Oil-Bearing Plants [=JEOBP] (2017), 20(3), 820-834

Peels of four local Citrus species (Citrus sinensis L. Obsbeck, Citrus reticulata Blanco, Citrus maxima Burm. and Citrus aurantifolia christm.) grown in a same locality under the same climatic conditions ... [more ▼]

Peels of four local Citrus species (Citrus sinensis L. Obsbeck, Citrus reticulata Blanco, Citrus maxima Burm. and Citrus aurantifolia christm.) grown in a same locality under the same climatic conditions were subjected to steam distillation. The essential oils and floral waters obtained were analyzed by gas chromatography coupled with a flame ionization detector (CPG-FID) and by gas chromatography coupled to a mass spectrometer (CPG-MS). The essential oils yields were ranged between 0.2 and 0.7 %. The qualitative and quantitative analyses show 74 compounds in all oils samples. The oils were largely dominated by hydrocarbon monoterpenes with limonene as major compound (91.5-94.0 %; 90.4-93.4 %; 77.7-93.7 % and 34.8-51.2 %) in oils from Citrus sinensis, Citrus reticulata, Citrus maxima and Citrus aurantifolia, respectively. In addition to limonene, oils of Citrus aurantifolia contained high amounts of β-pinene (6.8-14.4 %), pcymene (5.8-12.2 %), γ-terpinene (0.3 -7.4 %), neral (1.5-9.4 %), geraniol (1.9-12.7 %). Although presenting the same major compound (limonene), the oils had compositions that were qualitatively and quantitatively different. The enantiomeric analyses showed that the chiral major compounds were (R) - (+) - limonene, (S) - (-) – limonene, (1S) - (-) -β-pinene, (1R)-(+)-β-pinene and (S) - (+) - carvone. The hydrosols analyzed were composed of oxygenated compounds and did not have the same major compound. A qualitative and quantitative difference in chemical composition was noted between the Hydrosols. [less ▲]

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See detailApplication of a 3D unsteady surface panel method with flow separation model to horizontal axis wind turbines
Prasad, Chandra Shekhar; Dimitriadis, Grigorios ULiege

in Journal of Wind Engineering & Industrial Aerodynamics (2017), 166

This work describes the development and application of a 3D unsteady surface panel method with a separation model to the problem of simulating the flow around the blades of a horizontal axis wind turbine ... [more ▼]

This work describes the development and application of a 3D unsteady surface panel method with a separation model to the problem of simulating the flow around the blades of a horizontal axis wind turbine. The present method is intended as a design tool to capture the 3D time-dependent characteristics of both attached and separated flow conditions and is an extension of previous 2D approaches. Flow separation is modelled using a loose coupling procedure between the inviscid panel method and a quasi-3D viscous boundary layer solution. A separated wake is shed at the predicted separation points and propagated at the local flow velocity, just like the trailing edge wake. The methodology is demonstrated on the NREL phase-VI wind turbine test case and the model predictions are compared to experimental measurements. [less ▲]

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See detailBelgium
Husson, Jean-François ULiege

in Yearbook of Muslims in Europe (2017), 8

Developments having taken place in 2015 regarding Muslims in Belgium.

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See detailMiddle Ordovician cryptospores from the Saq-Hanadir transitional beds in the QSIM-801 well, Saudi Arabia
Vecoli, M.; Wellman, C.H.; Gerrienne, Philippe ULiege et al

in Revue de Micropaléontologie (2017), 60

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