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See detailNuclear and mitochondrial genetic structure in the Eurasian beaver (Castor fiber) - implications for future reintroductions
Senn, H.; Ogden, R.; Frosch, C. et al

in Evolutionary Applications (2014), 7(6), 645-662

Many reintroduction projects for conservation fail, and there are a large number of factors that may contribute to failure. Genetic analysis can be used to help stack the odds of a reintroduction in ... [more ▼]

Many reintroduction projects for conservation fail, and there are a large number of factors that may contribute to failure. Genetic analysis can be used to help stack the odds of a reintroduction in favour of success, by conducting assessment of source populations to evaluate the possibility of inbreeding and outbreeding depression and by conducting postrelease monitoring. In this study, we use a panel of 306 SNP (single nucleotide polymorphism) markers and 487-489 base pairs of mitochondrial DNA control region sequence data to examine 321 individuals from possible source populations of the Eurasian beaver for a reintroduction to Scotland. We use this information to reassess the phylogenetic history of the Eurasian beavers, to examine the genetic legacy of past reintroductions on the Eurasian landmass and to assess the future power of the genetic markers to conduct ongoing monitoring via parentage analysis and individual identification. We demonstrate the capacity of medium density genetic data (hundreds of SNPs) to provide information suitable for applied conservation and discuss the difficulty of balancing the need for high genetic diversity against phylogenetic best fit when choosing source population(s) for reintroduction. © 2014 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd. [less ▲]

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See detailWeighing Elephants with Kitchen Scales. The relevance of traditional performance measurement tools for social enterprises
Mouchamps, Hugues ULg

in International Journal of Productivity & Performance Management (2014), 63(6), 727-745

Purpose – The purpose of this paper is to analyze whether the use of current performance tools is consistent with the specific features of social enterprises. Design/methodology/approach – In a first ... [more ▼]

Purpose – The purpose of this paper is to analyze whether the use of current performance tools is consistent with the specific features of social enterprises. Design/methodology/approach – In a first phase, the main performance tools are divided into strategic planning tools, reporting tools and economic optimization techniques. In a second phase, 15 criteria emerge from a literature review to characterize the specific features of social enterprises. These criteria are brought together into an analytical framework, which makes it possible to analyze the relevance of each performance tool in relation to the specific features of social enterprises. Findings – What comes out of the analysis is that the tools globally fail to account for the specific features of social enterprises. That none of them met more than half of the criteria suggests the need for new performance tools based on strong theoretical bases. [less ▲]

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See detailInfluence of domestication process on immune response to repeated emersion stressors in Eurasian perch (Perca fluviatilis L.)
Douxfils, Jessica; Lambert, S; Mathieu, Cédric et al

in Comparative Biochemistry and Physiology. A : Comparative Physiology (2014), 173

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See detailMicro-Computed Tomography Based Computational Fluid Dynamics for the Determination of Shear Stresses in Scaffolds Within a Perfusion Bioreactor
Zermatten, Emilie; Vetsch, Jolanda Rita; Ruffoni, Davide ULg et al

in Annals of Biomedical Engineering (2014), 42(5), 1085-1094

Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous ... [more ▼]

Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk fibroin (SF) scaffold with an irregular network of interconnected pores. Their complex 3D geometries are imaged by micro-computed tomography and used in direct pore-level simulations of the entire scaffold-bioreactor system to numerically solve the governing mass and momentum conservation equations for fluid flow through porous media. The velocity field and wall shear stress distribution are determined for both scaffolds. The PCL scaffold exhibited an asymmetric distribution with peak and plateau, while the SF scaffold exhibited a homogenous distribution and conditioned the flow more efficiently than the PCL scaffold. The methodology guides the design and optimization of the scaffold geometry. [less ▲]

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See detailHost-habitat location by the parasitoid, Nasonia vitripennis Walker (Hymenoptera: Pteromalidae).
Frederickx, Christine ULg; Dekeirsschieter, Jessica ULg; Verheggen, François ULg et al

in Journal of Forensic Sciences (2014), 59

This study investigated the role of odorant cues used during host-habitat location by the generalist parasitoid, Nasonia vitripennis Walker. N vitripennis is a common parasitoid of Dipteran pupae found in ... [more ▼]

This study investigated the role of odorant cues used during host-habitat location by the generalist parasitoid, Nasonia vitripennis Walker. N vitripennis is a common parasitoid of Dipteran pupae found in association with decaying carrion. Behavioral assays were used to investigate the host-habitat searching behavior under different scenarios. First, we demonstrated N. vitripennis to be significantly attracted toward odorant cues associated with decaying meat. The biological activity of nine of the volatile molecules constituting the odor of decaying meat were tested on the searching behavior of parasitoid females through two complementary chemoecological approaches: electronantennography (EAG) and olfactometry bioassays. Butanoic acid and butan-1-ol elicited high olfactory responses, but no attraction was induced by these two chemicals. Behavioral assays showed that, among the VOCs tested, methyldisulfanylmethane (DMDS) was the only volatile chemical to induce attraction in N. vitripennis. [less ▲]

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See detailMarcos, la botarga. ¿Avatar o despedida del Subcomandante?
Vanden Berghe, Kristine ULg

in Asociación para el Fomento de los Estudios Históricos en Centroamérica (2014), 60

Se evalúa hasta qué punto la despedida del Sucomandante Marcos en mayo de 2014 se inscribe en la continuación de un discurso anterior o se desvía de él.

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See detailErratum: Characterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogels (Microporous and Mesoporous Materials (2014) 184 (97-104))
Haghgoo, M.; Yousefi, A. A.; Zohouriaan Mehr, M. J. et al

in Microporous and Mesoporous Materials (2014), 195

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See detailImmunosuppresseurs dans la prévention de la réaction du greffon contre l'hôte : rapport de la SFGM-TC
Belaiche, S.; Yafour, N.; Balcaen, S. et al

in Pathologie Biologie (2014), 62

In the attempt to harmonize dinical practîces between different French transplantation centers, the Frenell Society of Bane Marrow Transplantation and Cell Therapy (SFGM-TC) set up the fourth annual ... [more ▼]

In the attempt to harmonize dinical practîces between different French transplantation centers, the Frenell Society of Bane Marrow Transplantation and Cell Therapy (SFGM-TC) set up the fourth annual series of workshops which brought together practitioners from all member centers and taak place in September 2013 in Lille. Here we report our recommendatÎons regarding the use of immunosuppressive treatment in the prevention of graft versus hast disease: repOlt by the SFGM-TC. [less ▲]

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See detailMesozoic marine reptile palaeobiogeography in response to drifting plates
Bardet, Nathalie; Falconnet, Jocelyn; Fischer, Valentin ULg et al

in Gondwana Research (2014)

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically ... [more ▼]

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically, and most were the largest top-predators of the marine ecosystems of their time. The main groups were Ichthyosauria, Sauropterygia, Thalattosauria, and several lineages of Testudinata, Crocodyliformes, Rhynchocephalia and Squamata. Here we show that the palaeobiogeographical distribution of these marine reptiles closely followed the break-up of the supercontinent Pangaea and that they globally used the main marine corridors created by this break-up to disperse. Most Mesozoic marine reptile clades exhibit a cosmopolitan, or at least pandemic, distribution very early in their evolutionary history. The acquisition of morphological adaptations to a fully aquatic life, combined to special thermophysiological characteristics, are probably responsible for these animals to become efficient long-distance open-marine cruisers. Generally, Early Triassic taxa were near-shore animals mainly linked to the Tethys or Panthalassa coastlines. By the end of the Triassic and during the Jurassic, the break-up of Pangaea resulted in the formation of large marine corridors connecting the Tethys to the North Atlantic and Pacific realms, a trend increasing on during the Cretaceous with the expansion of the Atlantic Ocean and the break-up of the southern Gondwana, allowing open-sea marine reptiles to spread out over large distances. However, if large faunal interchanges were possible at a global scale following a dispersal model, some provinces, such as the Mediterranean Tethys, were characterized by a peculiar faunal identity, illustrating an absence of migration with time despite the apparent lack of barriers. So, if Continental Drift enabled global circulations and faunal interchanges via dispersals among Mesozoic marine reptiles, others parameters, such as ecological and biological constraints, probably also played a role in the local endemic distribution of some of these marine groups, as they do today. [less ▲]

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See detailCalcium, phosphorus, magnesium and vitamin D requirements of the preterm infants
Mimouni, F; Mandel, D; Lubetzky, R et al

in World Review of Nutrition and Dietetics (2014), 110

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See detailDoping-dependent band structure of LaAlO3/SrTiO3 interfaces by soft x-ray polarization-controlled resonant angle-resolved photoemission
Cancellieri, C.; Reinle-Schmitt, M.L.; Kobayashi, M. et al

in Physical Review B (2014), 89

Polarization-controlled synchrotron radiation was used to map the electronic structure of buried conducting interfaces of LaAlO3/SrTiO3 in a resonant angle-resolved photoemission experiment. A strong ... [more ▼]

Polarization-controlled synchrotron radiation was used to map the electronic structure of buried conducting interfaces of LaAlO3/SrTiO3 in a resonant angle-resolved photoemission experiment. A strong polarization dependence of the Fermi surface and band dispersions is demonstrated, highlighting different Ti 3d orbitals involved in two-dimensional (2D) conduction. Measurements on samples with different doping levels reveal different band occupancies and Fermi-surface areas.The photoemission results are directly compared with advanced first-principles calculations, carried out for different 3d-band filling levels connected with the 2D mobile carrier concentrations obtained from transport measurements, with indication of charge localization at the interface. [less ▲]

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See detailInteraction of fengycin with stratum corneum mimicking model membranes: a calorimetry study
Eeman, Marc; Oloffson, Gerd; Sparr, Emma et al

in Colloids and Surfaces B : Biointerfaces (2014), In Press

Based on its outstanding antifungal properties, it is reasonable to believe that fengycin might be efficient to topically treat localized dermatomycoses. Since most of the fungi species involved in the ... [more ▼]

Based on its outstanding antifungal properties, it is reasonable to believe that fengycin might be efficient to topically treat localized dermatomycoses. Since most of the fungi species involved in the formation of those mycotic skin diseases colonize primarily the stratum corneum (SC), studying the interaction between fengycin and SC-mimicking lipid membranes is a primary step to determine the potential of fengycin to overcome the physical barrier of the skin. In this respect, multilamellar lipid vesicles (MLVs), with a lipid composition mimicking that of the SC, were prepared and characterized by differential scanning calorimetry (DSC). The critical micelle concentration (CMC) of fengycin was also assessed under skin conditions and found to be 1.2 ± 0.1 μM. The molecular interactions of fengycin with SC-mimicking MLVs were investigated by both DSC and isothermal titration calorimetry (ITC). Results showed that the interactions were considerably affected by changes in lipid phase behaviour. At 40 °C and below, fengycin induced exothermic changes in the lipid structures suggesting that less-ordered lipid domains became more-ordered in presence of fengycin. At 60 °C, clearly endothermic interaction enthalpies were observed, which could arise from the “melting” of remaining solid domains enriched in high melting lipids that without fengycin melt at higher temperatures. [less ▲]

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See detailÉtat des lieux des flux céréaliers en Wallonie selon différentes filières d’utilisation
Delcour, Alice ULg; Van Stappen, Florence; Gheysens, Stéphanie et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 181-192

Survey on cereal resources in Wallonia according to their different uses. Survey on cereal resources in Wallonia according to their different uses. More than 60% of the arable cropped area in Wallonia is ... [more ▼]

Survey on cereal resources in Wallonia according to their different uses. Survey on cereal resources in Wallonia according to their different uses. More than 60% of the arable cropped area in Wallonia is dedicated to cereals. Cereal chains were initially aimed at ensuring food security but are now progressively oriented towards new non-food uses. Walloon cereal chains are now having to face up to new global challenges: to ensure the competitiveness and sustainability of vegetal and animal chains, to match society's expectations and to meet the biomass needs for energy uses and bio-based products. Within this framework, this research aims to evaluate the environmental and socio-economic sustainability of future scenarios of current and potential food and non-food uses for Walloon cereals. This paper, the first in a series of two, presents the current picture of Walloon cereal crops and their uses. Various steps are analyzed: production, collection, wholesale and processing. Four main uses characterize cereal processing: the so-called "4Fs", representing Food (human food uses), Feed (animal feed uses), Fuel (energy uses) and Fiber (material uses). Data collected from stakeholders in the Walloon cereal chain enabled us to assess cereal flows for the "4Fs", drawing a qualitative and a quantitative picture of Walloon cereal resources including the key elements of the cereal chains. This approach serves as a basis for a prospective exercise, described in a companion paper, which develops potential uses for Walloon cereal resources at the 2030 horizon. [less ▲]

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See detailEuroEcho-Imaging 2013: highlights.
Lancellotti, Patrizio ULg; Magne, Julien ULg; Cosyns, Bernard et al

in European Heart Journal - Cardiovascular Imaging (2014), 15(5), 483-488

The annual meeting of the European Association of Echocardiography (EuroEcho-Imaging) was held in Istanbul, Turkey. In the present paper, we present a summary of the 'Highlights' session.

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See detailCulture and hallucinations: overview and future directions
Laroi, Frank ULg; Luhrmann, T; Bell, V et al

in Schizophrenia Bulletin (2014), 40

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See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging. Part I.
Edvardsen, Thor; Plein, Sven; Saraste, Antti et al

in European heart journal cardiovascular Imaging (2014), 15(7), 730-735

The new multimodality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here, we summarize the most important studies from the journal's second year in ... [more ▼]

The new multimodality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here, we summarize the most important studies from the journal's second year in two articles. Part I of the review will focus on studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging, and Part II will focus on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

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See detailFirst-principles characterization of the P21ab ferroelectric phase of Aurivillius Bi2WO6
Djani-Ait, Hania ULg; Hermet, Patrick ULg; Ghosez, Philippe ULg

in Journal of Physical Chemistry C (2014), 118

The structural, dielectric, dynamical, elastic, piezoelectric and nonlinear optical (second-order susceptibility and Pockels tensors) properties of Bi2WO6 in its P21ab ferroelectric ground state are ... [more ▼]

The structural, dielectric, dynamical, elastic, piezoelectric and nonlinear optical (second-order susceptibility and Pockels tensors) properties of Bi2WO6 in its P21ab ferroelectric ground state are determined using density functional theory. The calculation of infrared and Raman spectra on single crystal allowed us to clarify the assignment of experimental phonon modes, considering the good agreement between the calculated and the experimental Raman spectra obtained on polycrystal. The calculation of the elastic constants con rms the elastic stability of the crystal and allow us to estimate the Young and shear moduli of polycrystalline samples. The piezoelectric constants have signi cant intrinsic values comparable to those of prototypical ABO3 ferroelectrics. The electro-optic response is strongly dominated by the ionic contribution of transverse optic modes, yielding sizable Pockels coe cients around 9 pm/V along the polar direction. [less ▲]

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See detailPeripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly.
SOMJA, Joan ULg; Bisig, B.; de Leval, L. et al

in Virchows Archiv : An International Journal of Pathology (2014)

Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14 ... [more ▼]

Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14)(p25;q11) and FISH-proved breakpoints in the IRF4 and TCRAD loci, leading to juxtaposition of both genes. A 64-year-old male patient presented with mild cytopenias and massive splenomegaly. Splenectomy showed diffuse red pulp involvement by a pleomorphic medium- to large-cell T-cell lymphoma with a CD2+ CD3+ CD5− CD7− CD4+ CD8+/− CD30− TCRbeta-F1+ immunophenotype, an activated cytotoxic profile, and strong MUM1 expression. The clinical course was marked by disease progression in the bone marrow under treatment and death at 4 months. In contrast with two t(6;14)(p25;q11.2)-positive lymphomas previously reported to be cytotoxic PTCL, NOS with bone marrow and skin involvement, this case was manifested by massive splenomegaly, expanding the clinical spectrum of PTCLs harboring t(6;14)(p25;q11.2) and supporting consideration of this translocation as a marker of biological aggressiveness. [less ▲]

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See detailField veterinary survey on clinical and economic impact of Schmallenberg virus in Belgium
Martinelle, Ludovic ULg; Dal Pozzo, Fabiana ULg; Gauthier, B et al

in Transboundary and Emerging Diseases (2014), 61(3), 285-288

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See detailConstitutional Aspects of FTAs: a Colombian Perspective
Parra Santamaria, Lusmiriam Andrea ULg; De Lombaerde, Philippe; Lizarazo, Liliana et al

in European Journal of Law (2014)

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See detailDeletion of exons 1-3 of the MEN1 gene in a large Italian family causes the loss of menin expression.
Zatelli, Maria Chiara; Tagliati, Federico; Di Ruvo, Mauro et al

in Familial cancer (2014)

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to ... [more ▼]

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to inactivating mutations of the MEN1 gene (chromosome 11q13). MEN1 mutations are mainly represented by nonsense, deletions/insertions, splice site or missense mutations that can be detected by direct sequencing of genomic DNA. However, MEN1 patients with large heterozygous deletions may escape classical genetic screening and may be misidentified as phenocopies, thereby hindering proper clinical surveillance. We employed a real-time polymerase chain reaction application, the TaqMan copy number variation assay, to evaluate a family in which we failed to identify an MEN1 mutation by direct sequencing, despite a clear clinical diagnosis of MEN1 syndrome. Using the TaqMan copy number variation assay we identified a large deletion of the MEN1 gene involving exons 1 and 2, in three affected family members, but not in the other nine family members that were to date clinically unaffected. The same genetic alteration was not found in a group of ten unaffected subjects, without family history of endocrine tumors. The MEN1 deletion was further confirmed by multiplex ligation-dependent probe amplification, which showed the deletion extended from exon 1 to exon 3. This new approach allowed us to correctly genetically diagnose three clinical MEN1 patients that were previously considered as MEN1 phenocopies. More importantly, we excluded the presence of genetic alterations in the unaffected family members. These results underline the importance of using a variety of available biotechnology approaches when pursuing a genetic diagnosis in a clinically suggestive setting of inherited endocrine cancer. [less ▲]

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See detailAntioxidant capacity of small dark fruits. Influence of cultivars and harvest time
Kevers, Claire ULg; PINCEMAIL, Joël ULg; Defraigne, Jean-Olivier ULg et al

in Journal of Berry Research (2014), 4

BACKGROUND: Small dark fruits represent one of the most important sources of bioactive compounds with antioxidant capacity in the human diet. The content of health-promoting antioxidants in these fruits ... [more ▼]

BACKGROUND: Small dark fruits represent one of the most important sources of bioactive compounds with antioxidant capacity in the human diet. The content of health-promoting antioxidants in these fruits may be important information to take into account when a fruit producer has to choose which cultivar to grow. OBJECTIVE: It is important to know how antioxidant capacity and antioxidant compounds as total phenolics and ascorbic acid vary between 9 small dark fruit species and for each species among cultivars (2 to 10 per species). METHODS: The antioxidant capacity (ORAC assay), total phenolic (Folin-Ciocalteu) and ascorbic acid content were measured in 9 fruits (plums, blackcurrants, blackberries, blueberries, cherries, redcurrants, raspberries, white currants and gooseberries) / 42 cultivars harvested at maturity during their high production period. RESULTS: The comparison of the average of the various cultivars of each small fruits showed that blackcurrants had the best antioxidant capacity (with plums), the highest ascorbic acid content and the highest total phenolic content (with blackberries). The present study shows that total phenolic compounds, ascorbic acid and antioxidant capacity strongly differed between genotypes of each small dark fruits. Other parameters as harvest time, culture conditions and maturity degree at the harvest may also influence the antioxidant capacity of small fruits. CONCLUSION: Among small dark fruits, blackcurrants have high qualities. Choices of variety, harvest time and maturity degree are important for all fruits. [less ▲]

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See detailAn open-air site from the recent Middle Palaeolithic in the Paris Basin (France): Les Bossats at Ormesson (Seine-et-Marne).
Bodu, Pierre; Salomon, Hélène ULg; Leroyer, Mathieu et al

in Quaternary International (2014), 331

In northern France, most of the sites attributed to the Middle Palaeolithic are open-air sites in which mainly lithic artefacts are found, due to taphonomic conditions often unfavourable to the ... [more ▼]

In northern France, most of the sites attributed to the Middle Palaeolithic are open-air sites in which mainly lithic artefacts are found, due to taphonomic conditions often unfavourable to the preservation of fauna. The lithic assemblages found in most of those open-air sites suggest that the activities on the camp sites were diversified, although flint knapping was often intense due to the proximity of sources of raw siliceous materials. With the exception of very rare open-air sites, fauna is poorly preserved and spatial and economic analyses may often be based on the spatial distribution of lithic artefacts, in particular based on refits and their analysis. Therefore the palaeoethnological approach is difficult to implement in most open-air areas. In contrast, in the Paris Basin, the study of more recent sites from the Tardiglacial, such as the Magdalenian sites of Pincevent or Etiolles, falls within this approach. The recent discovery (2009) and excavation of the open-air site of Ormesson (Seine-et-Marne - France) was initially intended to document a Gravettian occupation floor dated around 26,000 years uncal BP and related to a preferential bison hunt. Whilst checking the thickness of the loess in which the Gravettian level was found, several other prehistoric settlements were discovered (Chatelperronian, Middle Solutrean) including two units attributed to the Middle Palaeolithic. One of them, level 4, seems to be particularly well-preserved. It occurs between one and three meters below the main Upper Palaeolithic occupation. The lithic industry from level 4 belongs to a technical tradition generally attributed to the Middle Palaeolithic: discoid technology. The freshness of the material and the presence of bone fragments attributed in part to horse support a general good state of preservation of this occupation. The Mousterian remains seem to cover at least 500 m2, as currently estimated. Even more exceptional is the close spatial relationship between the discoid industry, the bone pieces, remains of fireplaces and especially the numerous fragments and nodules of red colouring materials. These were brought to the site where they were utilised by the Mousterians. The used surfaces show indisputable scraping traces and facets. These recent discoveries will certainly contribute to the debate on the cognitive capacities of nearly the last representatives of the Middle Palaeolithic and this within a complex stratigraphy which will allow us to make comparisons between the different periods. [less ▲]

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See detailIntroduction to Mapping Diasporic Subjectivities
Munos, Delphine ULg; Pandurang, Mala

in South Asian Diaspora (2014), 6(1), 1-5

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See detailCan EU Consumer Law Benefit from Behavioural Insights? An Analysis of the Unfair Practices Directive
Sibony, Anne-Lise ULg

in European Review of Private Law (2014), 22(6), 903-942

This paper explores in what ways insights from social psychology could be used to shape the interpretation of European law on unfair practices. It is argued that insights from social psychology on ... [more ▼]

This paper explores in what ways insights from social psychology could be used to shape the interpretation of European law on unfair practices. It is argued that insights from social psychology on influencing techniques are relevant to the interpretation of the directive on unfair practices. Both conceptual and empirical insights from psychology are valuable from a legal point of view. They could respectively translate as new elements of legal tests or as presumptions. [less ▲]

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See detailContinuous stroke volume estimation from aortic pressure using zero dimensional cardiovascular model: proof of concept study from porcine experiments.
Kamoi, Shun; Pretty, Christopher; Docherty, Paul et al

in PloS one (2014), 9(7), 102476

INTRODUCTION: Accurate, continuous, left ventricular stroke volume (SV) measurements can convey large amounts of information about patient hemodynamic status and response to therapy. However, direct ... [more ▼]

INTRODUCTION: Accurate, continuous, left ventricular stroke volume (SV) measurements can convey large amounts of information about patient hemodynamic status and response to therapy. However, direct measurements are highly invasive in clinical practice, and current procedures for estimating SV require specialized devices and significant approximation. METHOD: This study investigates the accuracy of a three element Windkessel model combined with an aortic pressure waveform to estimate SV. Aortic pressure is separated into two components capturing; 1) resistance and compliance, 2) characteristic impedance. This separation provides model-element relationships enabling SV to be estimated while requiring only one of the three element values to be known or estimated. Beat-to-beat SV estimation was performed using population-representative optimal values for each model element. This method was validated using measured SV data from porcine experiments (N = 3 female Pietrain pigs, 29-37 kg) in which both ventricular volume and aortic pressure waveforms were measured simultaneously. RESULTS: The median difference between measured SV from left ventricle (LV) output and estimated SV was 0.6 ml with a 90% range (5th-95th percentile) -12.4 ml-14.3 ml. During periods when changes in SV were induced, cross correlations in between estimated and measured SV were above R = 0.65 for all cases. CONCLUSION: The method presented demonstrates that the magnitude and trends of SV can be accurately estimated from pressure waveforms alone, without the need for identification of complex physiological metrics where strength of correlations may vary significantly from patient to patient. [less ▲]

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See detailLa responsabilisation au service des "nouvelles" institutions de soin: institutions de soin, contractualisation
Robert, Jocelyne ULg; Djenane, Majid

in Revue de sciences économiques et de gestion (2014), 14

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See detailFiber based optofluidic biosensors
Lismont, Marjorie ULg; Vandewalle, Nicolas ULg; Joris, Bernard ULg et al

in Applied Physics Letters (2014)

Medicinal diagnosis requires the development of innovative devices allowing the detection of small amounts of biological species. Among the large variety of available biosensors, the ones based on ... [more ▼]

Medicinal diagnosis requires the development of innovative devices allowing the detection of small amounts of biological species. Among the large variety of available biosensors, the ones based on fluorescence phenomenon are really promising. Here, we show a prototype of the basic unit of a multi-sensing biosensor combining optics and microfluidics benefits. This unit makes use of two crossed optical fibers: the first fiber is used to carry small probe molecules droplets and excite fluorescence, while the second one is devoted to target molecules droplets transport and fluorescence detection. Within this scheme, the interaction takes place in each fiber node. The main benefits of this detection setup are the absence of fibers functionalization, the use of microliter volumes of target and probe species, their separation before interaction, and a better detection limit compared to cuvettes setups. [less ▲]

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See detailStudy of residual stresses in bimetallic work rolls
Neira Torres, Ingrid ULg; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in Advanced Materials Research (2014), 996

An experimental campaign of compression tests, differential thermal analysis (DTA), differential scanning calorimetry ( DSC), dilatometry and microstructure analysis has been performed, as well as the ... [more ▼]

An experimental campaign of compression tests, differential thermal analysis (DTA), differential scanning calorimetry ( DSC), dilatometry and microstructure analysis has been performed, as well as the identification of the material data set for finite element ( FE) analysis of bimetallic rolls. This article numerically investigates the stress and strain fields after the cooling stage and it checks their effect on the subsequent heat treatment step. As bimetallic rolls have a different material for core and shell, the effect of the roll size and the shell thickness on residual stresses is also studied. [less ▲]

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See detailEvidence for an own-age bias in age estimation from voices in older persons
Moyse, Evelyne ULg; Beaufort, Aline ULg; Brédart, Serge ULg

in European Journal of Ageing (2014)

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the ... [more ▼]

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the occurrence of an own age effect on age estimation from voices has never been examined earlier using an experimental design in which the age of participants (young vs. old) and the age of voice stimuli (young vs. old) were crossed. Results revealed an own-age bias in older adults only. In comparison with younger adults, older participants showed age estimation abilities that are preserved for voices from their own age group and impaired for younger voices. This own age bias was absent in younger participants. [less ▲]

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See detailMesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et al

in Nephrology Dialysis Transplantation (2014), 29

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]

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See detailBetter neuronal efficiency after emotional competences training: an fMRI study
Hansenne, Michel ULg; Nelis, Delphine; Feyers, Dorothée ULg et al

in Psychologica Belgica (2014), 54

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See detailMineralogical and Physical Changes during Sintering of Plastic Red Clays from Sanaga Swampy Valley, Cameroon.
Nzeukou, Aubin; Traina, K.; Mjedo, E.R. et al

in International ceramique review (2014), 63(4), 186-192

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See detailA Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish
Genon, Sarah ULg; Bastin, Christine ULg; Angel, Lucie et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 54

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See detailLa durée de validité de l'arrêt de maintien de la détention préventive encas de requalification des faits
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (2014)

Selon la gravité des faits, la décision de maintien de la détention préventive prise par les juridictions d'instruction vaut pour un ou trois mois. Qu'en est-il en cas de requalification des faits par ... [more ▼]

Selon la gravité des faits, la décision de maintien de la détention préventive prise par les juridictions d'instruction vaut pour un ou trois mois. Qu'en est-il en cas de requalification des faits par celles-ci ? [less ▲]

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See detailControl of citrus blue mold by the antagonist yeast Pichia guilliermondii Z1: compatibility with commercial fruit waxes and putative mechanisms of action.
Lahlali, Rachid; Hamadi, Younes; Drider, R. et al

in Food Control (2014), 45

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an ... [more ▼]

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an alternative for synthetic fungicides, would be compatible with other postharvest practices used commercially. In particular, commercial fruit waxes can reduce their survival and effectiveness. The commercial fruit waxes tested, in combination at 20% with strain Z1, included microcrystalline, ester gum, candelilla, beeswax, montan, paraffin, rice bran, rosin maleic, carnauba, shellac, and one mixture shellac plus carnauba. Beeswax, paraffin, rosin maleic, carnauba, and shellac increased significantly strain Z1 survival in Petri dish assays. Candelilla, beeswax, rice bran, rosin maleic, carnauba, shellac, and shellacecarnauba mixture did not significantly reduce the strain Z1 yield on orange fruit surfaces compared to other waxes. With the exception of rosin maleic wax, none of the commercial fruit waxes or mixture increased significantly the ability of the formulated product of strain Z1 to control the postharvest pathogen Penicillium italicum on wounded orange fruit. When the formulated product of strain Z1 was used in combination with beeswax, strain Z1 retained the same efficacy. In contrast, microcrystalline, ester gum, candelilla, montan, paraffin, rice bran, carnauba, shellac, and shellac-carnauba mixture significantly reduced the effectiveness of the formulated product of strain Z1. No antibiosis was detected for strain Z1 against P. italicum. Strain Z1 inhibited the spore germination for the low juice concentration (up to 5%) when compared to the control. However, the addition of fresh juice after antagonist removal allowed the restoration of the germination of P. italicum spores; suggesting the possibility of competition for nutrients in the biocontrol activity of strain Z1. The study demonstrates the potential commercial application of strain Z1 with beeswax and rosin maleic wax for postharvest control of citrus blue mold. As biocontrol relies on competition for nutrients, an enriched formulation with nutrients is needed for reliable antifungal activity of this yeast strain [less ▲]

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See detailFaire cohabiter les objets sans domicile fixe. Chisholm et les logiques meinongiennes
Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(6), 85-111

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See detailInsight into the development of a carbonate platform through a multi-disciplinary approach - A case study from the Upper Devonian slope deposits of Mount Freikofel (Carnic Alps, Austria/Italy)
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Suttner, Thomas et al

in International Journal of Earth Sciences (2014), 103

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental ... [more ▼]

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental changes that occur in geological past is still limited. We herein undertake a multi-disciplinary approach (sedimentology, conodont biostratigraphy, magnetic susceptibility and geochemistry) of a long-term succession in the Carnic Alps which offers new insights into the peculiar evolution of one of the best example of Palaeozoic carbonate platform in Europe. The Freikofel section, located in the central part of the Carnic Alps represents an outstanding succession in a fore-reef setting, extending from the latest Givetian (indet. falsiovalis conodont Zones) to the early Famennian (Lower crepida conodont Zone). Sedimentological analysis allowed to propose a sedimentary model dominated by distal slope and fore-reef slope deposits. The most distal setting is characterized by an autochthonous pelagic sedimentation showing local occurrence of thin-bedded turbiditic deposits. In the fore-reef slope, in a more proximal setting, there is an accumulation of various autochthonous and allochthonous fine- to coarse-grained sediments originated from the interplay of gravity-flow currents derived from the shallow-water and deeper-water area. The temporal evolution of microfacies in the Freikofel section evolves in two main steps corresponding to the Freikofel (Unit 1) and the Pal (Unit 2) Limestones. Distal slope to fore-reef lithologies and associate changes are from base to top of the section: (U1) thick bedded litho- and bioclastic breccia beds with local fining upward sequence and fine-grained mudstone intercalations corresponding, in the fore-reef setting, to the dismantlement of the Eifelian – Frasnian carbonate platform during the early to late Frasnian time (falsiovalis to rhenana superzones) with one of the causes being the Late Givetian major rift pulse; (U2) occurrence of thin-bedded red nodular and cephalopod-bearing limestones with local lithoclastic grainstone intercalations corresponding to a significant deepening of the area and the progressive withdrawal of sedimentary influxes toward the basin, in relation with late Frasnian sea-level rise. Magnetic susceptibility and geochemical analyses were also performed along the Freikofel section and demonstrate the inherent-parallel link existing between variation in magnetic susceptibility values and proxy for terrestrial input. Interpretation of magnetic susceptibility in term of palaeoenvironmental processes reflect that even though distality remains the major parameter influencing magnetic susceptibility values, carbonate production and water agitation also play an important role. [less ▲]

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See detailLignin extraction from Mediterranean agro-wastes: Impact of pretreatment conditions on lignin chemical structure and thermal degradation behavior
Manara, Panagiota; Zabaniotou, Anastasia; Vanderghem, Caroline ULg et al

in Catalysis Today (2014), 223

Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical ... [more ▼]

Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical one. The organosolv process included lignocellulosic biomass treatment with formic acid/acetic acid/water (30/50/20, v/v%), for 3 h at 107 °C, while the physicochemical method was conducted by immersing the biomass in a water/ethanol (8/92, v/v%), H2SO4 0.32 M, solvent and further exposing the slurry to microwave irradiation (maximum 250 W) for 1/2 h at 150 °C. Both processes were evaluated regarding the achieved delignification and the purity of the extracted lignins. The effect of the pretreatment processes onto the structure and thermal decomposition behavior of the extracted lignins was investigated via FT-IR and TGA analysis, respectively. The objective of the research work was to investigate potential valorization routes for these biomass agro-residues in the context of a biorefinery, focusing on lignin extraction. The pretreatment results showed that the obtained lignins, derived from both procedures, were of high purity (>82 wt%). Under the organosolv procedure, peach kernel delignification showed the maximum value (∼16 wt%), while under microwave pretreatment, olive kernel delignification showed the maximum value (∼35 wt%). Grape pomace/seeds appeared to be the most resistant in both treatments. [less ▲]

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See detailDon't drop the guard: osteoporosis is still a fatal disease !
Reginster, Jean-Yves ULg

in Medicographia (2014), 36(2), 139-140

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See detailINDICATIONS D’UN TRAITEMENT DE RADIOTHERAPIE LOCALE APRES PROSTATECTOMIE RADICALE
HERMESSE, Johanne ULg; WERENNE, Xavier ULg; PHILIPPI, Sven ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 29-31

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See detailAre Hydrogen-Bonded Charge Transfer Crystals Room Temperature Ferroelectrics?
D'Avino, Gabriele ULg; Verstraete, Matthieu ULg

in Physical Review Letters (2014), 113

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See detailA frontal approach to hex-dominant mesh generation
Baudouin, Tristan Carrier; Remacle, Jean-François; Marchandise, Emilie et al

in Advanced Modeling and Simulation in Engineering Sciences (2014), 1(1), 1-30

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See detailA review of the microbiological hazards of raw milk from animal species other than cows
Verraes, Claire; Claeys, Wendy; Cardoen, Sabine et al

in International Dairy Journal (2014), sous presse

This review concentrates on information concerning the microbiological hazards that can be present in raw milk from animal species other than cows. Total bacterial counts of raw milk are described for ... [more ▼]

This review concentrates on information concerning the microbiological hazards that can be present in raw milk from animal species other than cows. Total bacterial counts of raw milk are described for several animal species, indicating the quality of the milk, then frequencies of occurrence of several human pathogenic microorganisms are considered and, finally, human cases of illness and outbreaks due to the consumption of raw milk from non-bovine species are covered. Only raw milk from goats and camels has so far been reported to be associated with outbreaks. Raw milk from horse and donkey may have a higher microbiological quality than raw milk from other animal species, although human pathogenic strains of Streptococcus are considered as a microbiological hazard for such milk. For raw milk from other animal species, the main microbiological hazards seem to be human pathogenic Escherichia coli, Campylobacter spp., tick-borne encephalitis virus and Brucella spp. [less ▲]

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See detailInflammation as a link between obesity, metabolic syndrome and type 2 diabetes
ESSER, Nathalie ULg; Legrand, Sylvie ULg; Piette, Jacques ULg et al

in Diabetes Research & Clinical Practice (2014)

It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic ... [more ▼]

It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose tissue, liver, muscle and pancreas are themselves sites of inflammation in presence of obesity. An infiltration of macrophages and other immune cells is observed in these tissues associated with a cell population shift from an anti-inflammatory to a pro-inflammatory profile. These cells are crucial for the production of pro-inflammatory cytokines, which act in an autocrine and paracrine manner to interfere with insulin signaling in peripheral tissues or induce β-cell dysfunction and subsequent insulin deficiency. Particularly, the pro-inflammatory interleukin-1β is implicated in the pathogenesis of type 2 diabetes through the activation of the NLRP3 inflammasome. The objectives of this review are to expose recent data supporting the role of the immune system in the pathogenesis of insulin resistance and type 2 diabetes and to examine various mechanisms underlying this relationship. If type 2 diabetes is an inflammatory disease, anti-inflammarory therapies could have a place in prevention and treatment of type 2 diabetes. [less ▲]

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See detailMethods to Increase the Robustness of Finite-Volume Flow Models in Thermodynamic Systems
Quoilin, Sylvain ULg; Bell, Ian ULg; Desideri, Adriano ULg et al

in Energies (2014), 7(3), 1621-1640

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when ... [more ▼]

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when modeling 1D heat exchangers or piping, e.g., in thermodynamic cycles involving a phase change. Issues, such as chattering or stiff systems, can lead to low simulation speed, instabilities and simulation failures. In the particular case of two-phase flow models, they are usually linked to a discontinuity in the density derivative between the liquid and two-phase zones. In this work, several methods to tackle numerical problems are developed, described, implemented and compared. In addition, methods available in the literature are also implemented and compared to the proposed approaches. Results suggest that the robustness of the models can be significantly increased with these different methods, at the price of a small increase of the error in the mass and energy balances. [less ▲]

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See detailLa dermocosmétique en appui de traitements oncologiques ciblés.
FRANCHIMONT, Claudine ULg; Lesuisse, Marianne; PIERARD, Gérald ULg

in Revue Médicale de Liège (2014), 69(1), 35-37

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the ... [more ▼]

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the unwanted skin conditions without interfering with the targeted therapeutic effects. However, evidence-based support for using dermocosmetic products as adjunctive cancer treatment remains scarce. It remains nonetheless that the clinical perception is unanimously favourable for such procedure. [less ▲]

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See detailExpression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis
CREVECOEUR, Julie ULg; Kaminski, RM; Rogister, Bernard ULg et al

in Neuropathology & Applied Neurobiology (2014), 40(2), 191-204

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See detailCommunication soignant-soigné
Faymonville, Marie-Elisabeth ULg; Nyssen, Anne-Sophie ULg

in Douleur et Analgésie (2014)

La communication fait partie intégrante de la relation de soin. Mais, quelle attention portons-nous aux mots que nous utilisons au quotidien dans nos interactions ? Dans cet article, nous n’avons pas la ... [more ▼]

La communication fait partie intégrante de la relation de soin. Mais, quelle attention portons-nous aux mots que nous utilisons au quotidien dans nos interactions ? Dans cet article, nous n’avons pas la prétention de faire un exposé exhaustif sur la communication thérapeutique. Nous invitons le lecteur à observer un regard critique sur nos échanges verbaux et non verbaux. Nous montrons notamment comment les mots peuvent être porteurs de suggestions négatives et avoir un « effet nocebo » et comment l’apprentissage de compétences communicationnelles constitue un outil puissant permettant d’améliorer la qualité des soins et le bienêtre au travail [less ▲]

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See detailPlanatophyton gen. nov., a late Early or Middle Devonian euphyllophyte from Xinjiang, North-West China
Gerrienne, Philippe ULg; Meyer-Berthaud; Yang, N. et al

in Review of Palaeobotany and Palynology (2014)

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See detailLe point de rosée en berne et la couche cornée hivernale.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; Delvenne, Philippe ULg

in Revue Médicale de Liège (2014), 69(2), 68-71

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed ... [more ▼]

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy. Keywords : Stratum corneum - Dew point [less ▲]

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See detailLa dermatoporose, un "vintage" de l'atrophodermie et de la "peau transparente".
FRANCHIMONT, Claudine ULg; Hermanns, J.F.; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2014), 69

Le vieillissement de la peau se marque à terme par une atrophodermie, parfois sévère. La corticothérapie, qu’elle soit systémique ou topique, exerce un effet atrophiant qui copie l’effet du grand âge. Cet ... [more ▼]

Le vieillissement de la peau se marque à terme par une atrophodermie, parfois sévère. La corticothérapie, qu’elle soit systémique ou topique, exerce un effet atrophiant qui copie l’effet du grand âge. Cet état d’atrophodermie a été décrit comme la «peau transparente» il y a une quarantaine d’années, et il a reçu plus récemment la nouvelle dénomination de dermatoporose. Il est connu de longue date que cet état entraîne des conséquences cliniques parfois majeures qui conduisent à des lésions diverses sous forme de purpura de Bateman, de cicatrices stellaires, et de plaies faisant suite à des traumatismes mineurs. [less ▲]

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See detailUnited but (un)equal: human capital, probability of divorce, and the marriage contract
Cremer, Helmuh; Pestieau, Pierre ULg; Roeder, Kerstin

in Journal of Population Economics (2014)

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See detailGeometric ferroelectricity in fluoroperovskites
Garcia-Castro, A. C.; Spaldin, Nicola A.; Romero, A. H. et al

in Physical Review B (2014), 89

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are ... [more ▼]

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are paraelectric (Pnma phase), we find that many fluoroperovskites have a ferroelectric instability in their high-symmetry cubic structure that is of similar amplitude to that commonly found in oxide perovskites. In contrast to the oxides, however, the fluorides have nominal Born effective charges, indicating a different mechanism for the instability.We show that the instability originates from ionic size effects, and is therefore in most cases largely insensitive to pressure and strain, again in contrast to the oxide perovskites. An exception is NaMnF3, where coherent epitaxial strain matching to a substrate with equal in-plane lattice constants destabilizes the bulk Pnma structure, leading to a ferroelectric, and indeed multiferroic, ground state with an unusual polarization/strain response. [less ▲]

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See detailDermatophytes transmis par les animaux domestiques
Monod, M; Fratti, B; Mignon, Bernard ULg et al

in Revue Médicale Suisse (2014), 10

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See detailCombined effects of climate, resource availability, and plant traits on biomass produced in a Mediterranean rangeland
Chollet, Simon; Rambal, Serge; Fayolle, Adeline ULg et al

in Ecology (2014), 95(3), 737-748

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities ... [more ▼]

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities. However, the combined effects of these different factors remain largely unknown. The aim of the present study was to unravel the causes of variations in the standing biomass of plant communities using a long-term experiment conducted in a Mediterranean rangeland of Southern France. Two management regimes, sheep grazing and grazing associated with mineral fertilization, were applied to different areas of the study site over the past 25 years. Abiotic (temperature, available water, nutrients) and biotic (components of the functional structure communities) factors were considered to explain interannual and spatial variations in standing biomass in these rangelands. Standing biomass was highly predictable, with the best model explaining ;80% of variations in the amount of biomass produced, but the variation explained by abiotic and biotic factors was dependent on the season and on the management regime. Abiotic factors were found to have comparable effects in both management regimes: The amount of biomass produced in the spring was limited by cold temperatures, while it was limited by water availability and high temperatures in the summer. In the fertilized community, the progressive change in the functional structure of the communities had significant effects on the amount of biomass produced: the dominance of few productive species which were functionally close led to higher peak standing biomass in spring. [less ▲]

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See detailInfluence de l'environnement et des pratiques culturales sur la productivité de Jatropha curcas L. en Afrique subsaharienne (synthèse bibliographique)
Minengu, Jean de Dieu; Mobambo, Patrick; Mergeai, Guy ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 290-300

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the ... [more ▼]

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the development of the plants was low and yields during the first years of cultivation were mostly disappointing. The low yields obtained in marginal conditions led to the belief that the cultivation of Jatropha could only be profitable in areas with fertile soils and sufficiently humid climates, which would place the plants in direct competition with food production. This article analyzes the available scientific knowledge regarding the ecological and technical factors influencing the productivity of J. curcas and suggests possible solutions for improving its performance in sub-Saharan Africa. [less ▲]

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See detailPrevalence of Campylobacter among goats and retail goat meat in Congo
Kabwang a Mpalang, Rosette; BOREUX, Raphaël ULg; Melin, Pierrette ULg et al

in Journal of Infection in Developing Countries [=JIDC] (2014), 8

Background: The prevalence of Campylobacter jejuni and Campylobacter coli was determined in goat and goat meat sold at retail outlets in Lubumbashi, Democratic Republic of Congo (DR Congo). Methodology: A ... [more ▼]

Background: The prevalence of Campylobacter jejuni and Campylobacter coli was determined in goat and goat meat sold at retail outlets in Lubumbashi, Democratic Republic of Congo (DR Congo). Methodology: A total of 644 samples, including 177 goat meat, 86 goat stomachs, 139 ready to eat (RTE) goat skewers, and 242 goat faecal samples were examined for the presence of Campylobacter jejuni and Campylobacter coli using polymerase chain reaction. Results: Overall, Campylobacter spp. were found in 34.6% of the examined samples. C. jejuni was isolated in 10.1% and C. coli in 26.7% of samples. Only 2.2% of all samples were positive for both species. There was a significant association between the prevalence of C. coli and the type of sample (p < 0.05). The overall prevalence of Campylobacter in different sample groups was 41.2%, 37.2%, 23.7%, and 35.1% for goat meat, goat stomachs, RTE goat skewers, and goat faecal samples, respectively. There was no significant difference (p > 0.05) between the prevalence observed in the rainy season (16.7%) and the dry season (20.0%). Moreover, the overall prevalence of Campylobacter in slaughter sites, open-air markets, warehouses, and semi-open-air markets was 28.2%, 34.2%, 35.4%, and 42.9%, respectively. Statistically, there was no influence of the sample collection site on the frequency of isolation of Campylobacter (p > 0.05). Conclusion: This study shows that, considering the relatively high prevalence of this [less ▲]

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See detailRomosozumab in Postmenopausal Women with Low Bone Mineral Density.
McClung, Michael R.; Grauer, Andreas; Boonen, Steven et al

in The New England journal of medicine (2014), 370

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. Methods In a phase 2, multicenter ... [more ▼]

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. Methods In a phase 2, multicenter, international, randomized, placebo-controlled, parallel-group, eight-group study, we evaluated the efficacy and safety of romosozumab over a 12-month period in 419 postmenopausal women, 55 to 85 years of age, who had low bone mineral density (a T score of -2.0 or less at the lumbar spine, total hip, or femoral neck and -3.5 or more at each of the three sites). Participants were randomly assigned to receive subcutaneous romosozumab monthly (at a dose of 70 mg, 140 mg, or 210 mg) or every 3 months (140 mg or 210 mg), subcutaneous placebo, or an open-label active comparator - oral alendronate (70 mg weekly) or subcutaneous teriparatide (20 mug daily). The primary end point was the percentage change from baseline in bone mineral density at the lumbar spine at 12 months. Secondary end points included percentage changes in bone mineral density at other sites and in markers of bone turnover. Results All dose levels of romosozumab were associated with significant increases in bone mineral density at the lumbar spine, including an increase of 11.3% with the 210-mg monthly dose, as compared with a decrease of 0.1% with placebo and increases of 4.1% with alendronate and 7.1% with teriparatide. Romosozumab was also associated with large increases in bone mineral density at the total hip and femoral neck, as well as transitory increases in bone-formation markers and sustained decreases in a bone-resorption marker. Except for mild, generally nonrecurring injection-site reactions with romosozumab, adverse events were similar among groups. Conclusions In postmenopausal women with low bone mass, romosozumab was associated with increased bone mineral density and bone formation and with decreased bone resorption. (Funded by Amgen and UCB Pharma; ClinicalTrials.gov number, NCT00896532 .). [less ▲]

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See detailLa description des zones climatiques terrestres. À propos d’Ératosthène, Hermès, 16, 3-16 POWELL et Cicéron, Songe de Scipion, 21
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2014), 83

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See detailLa responsabilisation au service des "nouvelles" institutions de soin: institutions de soin, contractualisation
Robert, Jocelyne ULg; Djenane, Majid

in Revue de sciences économiques et de gestion (2014), 14

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See detailWhat is the Ability Emotional Intelligence Test (MSCEIT) good for? An evaluation using item response theory.
Fiori, Marina; Antonietti, Jean-Philippe; Mikolajczak, Moira et al

in PloS one (2014), 9(6), 98827

The ability approach has been indicated as promising for advancing research in emotional intelligence (EI). However, there is scarcity of tests measuring EI as a form of intelligence. The Mayer Salovey ... [more ▼]

The ability approach has been indicated as promising for advancing research in emotional intelligence (EI). However, there is scarcity of tests measuring EI as a form of intelligence. The Mayer Salovey Caruso Emotional Intelligence Test, or MSCEIT, is among the few available and the most widespread measure of EI as an ability. This implies that conclusions about the value of EI as a meaningful construct and about its utility in predicting various outcomes mainly rely on the properties of this test. We tested whether individuals who have the highest probability of choosing the most correct response on any item of the test are also those who have the strongest EI ability. Results showed that this is not the case for most items: The answer indicated by experts as the most correct in several cases was not associated with the highest ability; furthermore, items appeared too easy to challenge individuals high in EI. Overall results suggest that the MSCEIT is best suited to discriminate persons at the low end of the trait. Results are discussed in light of applied and theoretical considerations. [less ▲]

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See detailLand rights as an engine of growth ? An analysis of Cambodian landgrabs in the context of development theory
Rudi, Lisa-Marie; Azadi, Hossein; Witlox, Frank et al

in Land Use Policy (2014), (38), 564-572

Forceful evictions have become a serious problem in Cambodia with an increasing number of fami-lies being deprived of their land, homes and livelihoods without compensation. This article analysesCambodian ... [more ▼]

Forceful evictions have become a serious problem in Cambodia with an increasing number of fami-lies being deprived of their land, homes and livelihoods without compensation. This article analysesCambodian land rights in the context of economic development theory. It assesses whether increas-ing economic inequalities, stemming from forceful evictions, can be categorized as an impediment toCambodian economic growth. The Cambodian case illustrates that a lack of good governance due tocorruption leads to the unequal distribution of land which, in turn, causes inequitable economic devel-opment. The paper concludes that Cambodia is trapped in a vicious cycle of inequality, which is upheld byelites who benefit from evictions and land concessions while evictees become trapped in poverty. Giventhat the population is growing angrier, the article warns of potential for a violent revolution that couldhave disastrous consequences for the Cambodian kingdom, a country that recently emerged from yearsof civil conflicts and is still in the process of rebuilding its social fabric. [less ▲]

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See detailUsefulness of 3D-PISA as compared to guideline endorsed parameters for mitral regurgitation quantification.
Schmidt, Frank P.; Gniewosz, Theresa; Jabs, Alexander et al

in The international journal of cardiovascular imaging (2014)

This study was intended to evaluate the diagnostic value of three dimensional proximal isovelocity surface area (3D PISA) derived effective regurgitant orifice area (EROA) and the accuracy of automatic 3D ... [more ▼]

This study was intended to evaluate the diagnostic value of three dimensional proximal isovelocity surface area (3D PISA) derived effective regurgitant orifice area (EROA) and the accuracy of automatic 3D PISA detection in a population resembling clinical practice. Quantification of mitral regurgitation (MR) remains challenging and 3D PISA EROA is a novel diagnostic tool with promising results. However its' usefulness compared to guideline endorsed parameters has not been shown. In 93 consecutive patients examined in routine practice conventional parameters and 3D-datasets for offline 3D PISA evaluation were recorded. EROA was determined from the largest (peak) PISA and also averaged over systole for meanEROA. Results of 3D PISA calculation were compared with a combination of expert grading by two examiners and two scores for MR grading. In receiver operator characteristic-analysis the meanEROA as determined by 3D PISA had the best diagnostic value (AUC = 0.907 CI 0.832-0.983) as compared to peakEROA (AUC 0.840 CI 0.739-0.941), vena contracta width (AUC 0.831 CI 0.745-0.918) and 2D PISA (AUC 0.747 CI 0.644-0.850). A meanEROA of 0.15 cm2 had a sensitivity of 88.2 % and a specificity of 81.4 % for distinguishing severe from non-severe MR. Semiautomatic 3D PISA detection correlated very well with manually corrected values (r = 0.955). Semiautomatic 3D PISA measurement is feasible in a clinical population and has better diagnostic value compared to 2D PISA. Calculation of mean EROA throughout systole further improves diagnostic value compared to conventional parameters. [less ▲]

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See detailGermanistik und Sprachlandschaft in Belgien
Küpper, Achim ULg

in Newsletter des Deutschen Germanistenverbands (2014), (1), 14-16

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See detailIntense pulsed light in infantile hemangiomas.
PAQUET, Philippe ULg; Caucanas, Marie; FRANCHIMONT, Claudine ULg et al

in Open Access Journal of Science and Technology (2014), 2

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of ... [more ▼]

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of well-suited beta-blockers, as well as noncoherent light and laser therapies. The aim of this work was to revisit the effect of intense pulsed light (IPL) therapy on infantile hemangioma. Information was collected from the peer-reviewed literature and illustrated by personal cases. When applied early in the evolution of infantile hemangiomas, IPL treatment stops the growth phase and induces regression with minimal cosmetic adverse effects and psychological damage. Initiating an adequate treatment is important because damage due to hemangiomas can be diminished by a timely and adequate approach. Beta-blockers have revolutionized the therapeutic strategy of infantile hemangiomas. The flash light therapy (IPL) represents an alternative therapy for some patients. [less ▲]

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See detailGouvy/Bovigny : empierrement à Courtil "Obourcy"
Drailly, Christelle; Thiebaux, Aurélie ULg; Goemaere, Eric

in Chronique de l'Archéologie Wallonne (2014), 21

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See detailDe Jacques Antoine aux éditions des Eperonniers : l'édition littéraire en Belgique au passé et au présent (première partie)
Durand, Pascal ULg; Habrand, Tanguy ULg

in Textyles : Revue des Lettres Belges de Langue Française (2014), 45

Première partie (POSITION ÉDITORIALE ET PATRIMONIALISATION LITTÉRAIRE : JACQUES ANTOINE) d'un article en deux volets dont le second porte sur la transition des éditions Jacques Antoine aux éditions des ... [more ▼]

Première partie (POSITION ÉDITORIALE ET PATRIMONIALISATION LITTÉRAIRE : JACQUES ANTOINE) d'un article en deux volets dont le second porte sur la transition des éditions Jacques Antoine aux éditions des Eperonniers et sur l'histoire et la politique éditoriale de cette dernière maison (CRÉATION CONTEMPORAINE ET POLITIQUES DU LIVRE : LYSIANE D’HAEYERE AUX ÉPERONNIERS). [less ▲]

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See detailUne Histoire d'hypophyse, évolution des représentations et des concepts au fil du temps.
JEDIDI, Haroun ULg; JEDIDI, Zayd ULg; BECKERS, Albert ULg

in Revue Médicale de Liège (2014)

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez ... [more ▼]

De par le rôle essentiel qu’il occupe, l’axe hypothalamo-hypophysaire, véritable chef d’orchestre du système endocrinien, constitue au niveau médical un important pourvoyeur de désordres. Il est assez paradoxal de constater que malgré l’importance de ce système, celui-ci ait été presque complètement méconnu par les physiologistes des siècles passés. En nous basant sur les conceptions physiologiques des médecins philosophes de l’antiquité puis du moyen-âge et de la renaissance nous tenterons de comprendre pourquoi le rôle de l’hypophyse a été si longtemps méconnu. [less ▲]

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See detailCoherent Backscattering in Fock Space: A Signature of Quantum Many-Body Interference in Interacting Bosonic Systems
Engl, Thomas; Dujardin, Julien ULg; Argüelles, Arturo et al

in Physical Review Letters (2014), 112

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with ... [more ▼]

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with respect to variations of external parameters even though it represents a dynamical manifestation of the delicate superposition principle in Fock space. It is a genuine quantum many-body effect that lies beyond the reach of any mean-field approach. Using a semiclassical approach based on interfering paths in Fock space, we calculate the magnitude of the backscattering peak and its dependence on gauge fields that break time-reversal invariance. We confirm our predictions by comparing them to exact quantum evolution probabilities in Bose-Hubbard models, and discuss their relevance in the context of many-body thermalization. [less ▲]

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See detailThe political choices of emigrants voting in home country elections: A socio-political analysis of the electoral behaviour of Bolivian external voters
Lafleur, Jean-Michel ULg; Sanchez-Dominguez, Maria

in Migration Studies (2014)

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this ... [more ▼]

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this question remains largely unanswered. Basing ourselves on the existing political science literature on electoral behaviour and on the migration literature on immigrants’ participation in host country politics, we isolate different hypotheses that explain emigrants’ preferences in home country politics. We then build four models of voters based on these hypotheses: the social group voter, the ideological voter, the interest-driven voter, and the transnational voter. In the second part of the paper, we verify the validity of these models using the results of a survey carried out with Bolivian emigrants who took part in the 2009 Bolivian presidential election from abroad. Overall, this article identifies the drivers of immigrant transnational political participation and contributes to current debates on social remittances. [less ▲]

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See detailContrasting biogeochemical characteristics of the Oubangui River and tributaries (Congo River basin)
Bouillon, Steven; Yambélé, Athanase; Gillikin, David P. et al

in Scientific Reports (2014), 4

The Oubangui is a major tributary of the Congo River. We describe the biogeochemistry of contrasting tributaries within its central catchment, with watershed vegetation ranging from wooded savannahs to ... [more ▼]

The Oubangui is a major tributary of the Congo River. We describe the biogeochemistry of contrasting tributaries within its central catchment, with watershed vegetation ranging from wooded savannahs to humid rainforest. Compared to a 2-year monitoring record on the mainstem Oubangui, these tributaries show a wide range of biogeochemical signatures, from highly diluted blackwaters (low turbidity, pH, conductivity, and total alkalinity) in rainforests to those more typical for savannah systems. Spectral analyses of chromophoric dissolved organic matter showed wide temporal variations in the Oubangui compared to spatio-temporal variations in the tributaries, and confirm that different pools of dissolved organic carbon are mobilized during different hydrological stages. d13C of dissolved inorganic carbon ranged between -28.1 per mil and -25.8 per mil, and was strongly correlated to both partial pressure of CO2 and to the estimated contribution of carbonate weathering to total alkalinity, suggesting an important control of the weathering regime on CO2 fluxes. All tributaries were oversaturated in dissolved greenhouse gases (CH4, N2O, CO2), with highest levels in rivers draining rainforest. The high diversity observed underscores the importance of sampling that covers the variability in subcatchment characteristics, to improve our understanding of biogeochemical cycling in the Congo Basin. [less ▲]

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See detailReproductive ecology of Coula edulis Baill., source of a valuable non-timber forest product
Moupela, Christian ULg; Doucet, Jean-Louis ULg; Daïnou, Kasso ULg et al

in Tropical Ecology (2014), 55(3), 327-338

The reproductive ecology of Coula edulis (Olacaceae), source of a highly valuable non-timber product for African populations, has been investigated on a large tree sample size in a Gabonese forest for a 3 ... [more ▼]

The reproductive ecology of Coula edulis (Olacaceae), source of a highly valuable non-timber product for African populations, has been investigated on a large tree sample size in a Gabonese forest for a 3-year period, in order to propose options for its domestication. Reproduction is annual and the minimum tree diameter for flowering was 10.6 cm while the diameter for regular fructification was 23 cm. The annual diameter increment (ADI; mean = 0.22 cm year-1) was affected by crown exposure, but not by initial tree diameter or fruit production. Tree diameter influenced fruiting frequency and fruit production. There was a strong correlation between fruit production of 2011 and 2012 (Pearson's r = 0.85; P < 0.001), suggesting a high heritability of that trait. Phenotypical selection should be performed prior to any propagation activity. Moreover, as most of C. edulis fruits were sterile (64 %), we propose that sylvicultural strategies should be based on vegetative propagation. [less ▲]

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See detailFeruloylbenzotriazole and Weinreb Amide as Bioinspired Building Blocks: A Reactivity Study towards O-, N-, S-, and C-Nucleophiles
Roman, Bart; Monbaliu, Jean-Christophe ULg; De Coen, Laurens et al

in European Journal of Organic Chemistry (2014)

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See detailExternal nasal valve collapse: validation of novel outcome measurement tool.
POIRRIER, Anne-Lise ULg; Ahluwalia, S.; Kwame, I. et al

in Rhinology (2014), 52(2), 127-32

BACKGROUND: We aim to validate a clinical scoring system of external nasal valve collapse. External nasal valve collapse is a rare and challenging condition. We attempted to simplify the examination of ... [more ▼]

BACKGROUND: We aim to validate a clinical scoring system of external nasal valve collapse. External nasal valve collapse is a rare and challenging condition. We attempted to simplify the examination of the external valve, the surgical planning and the outcome measure. To validate our external valve score, we first assessed its reliability (inter-rater agreement and test-retest repeatability). We secondly considered the clinical relevance by using our scoring system in patients undergoing septorhinoplasty for external valve collapse. METHODOLOGY: For validation, 16 Rhinologists scored patients separately on two occasions. For the clinical relevance, 26 patients with external valve collapse were scored pre- and post-operatively (responsiveness). The external valve score was correlated to peak nasal inspiratory flow. RESULTS: The devised scoring system was reliable (substantial agreement between 16 surgeons with reproducibility over time). All patients in our prospective series showed significant improvement in their external valve score. The quality of life measured by the SNOT-22 tool showed significant improvement after surgery. CONCLUSION: External nasal valve collapse can be diagnosed and graded using this simple scoring system in the outpatient clinic. This paper reinforces the pivotal role of septorhinoplasty surgery in nasal airway reconstruction and the ongoing need to quantify success. [less ▲]

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See detailLa vignette diagnostique de l'etudiant. Diagnostic et evaluation d'une hypoglycemie chez le patient diabetique.
Scheen, André ULg

in Revue medicale de Liege (2014), 69(2), 110-5

Hypoglycaemic episodes are rather common among diabetic patients, especially those treated with sulfonylureas or insulin (more in type 1 than in type 2 diabetes). The presentation of hypoglycaemia may ... [more ▼]

Hypoglycaemic episodes are rather common among diabetic patients, especially those treated with sulfonylureas or insulin (more in type 1 than in type 2 diabetes). The presentation of hypoglycaemia may considerably vary from patient-to-patient and from time-to-time in a given patient. With the illustration of a clinical case, we will describe the characteristics of the three main types of hypoglycaemia: severe hypoglycaemia (with or without coma), symptomatic hypoglycaemia (with or without confirmation) and asymptomatic hypoglycaemia ("hypoglycaemia unawareness") discovered as a low blood glucose measurement. We will also briefly analyse the reasons of such differences and the potential clinical consequences that these three main types of hypoglycaemia may exert in the real life of diabetic patients. [less ▲]

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See detailAider à vivre, aider à mourir
Jamoulle, Marc ULg

in Pratiques : les Cahiers de la Médecine Utopique (2014), 66

Aider à vivre et aider à mourir ne sont pas tellement éloignés l’un de l’autre en médecine de famille. Au quotidien, la différence est tranchée et la limite claire. Il y a les vivants et il y a les morts ... [more ▼]

Aider à vivre et aider à mourir ne sont pas tellement éloignés l’un de l’autre en médecine de famille. Au quotidien, la différence est tranchée et la limite claire. Il y a les vivants et il y a les morts. Pas si sûr. Entre vie et mort, le fil est parfois ténu. [less ▲]

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See detailEffect of palm oil enzymatic interesterification on physicochemical and structural properties of mixed fat blends.
Danthine, Sabine ULg; Lefebure, Emilie ULg; Nhu Trin, Hoa et al

in Journal of the American Oil Chemists' Society (2014), 91

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See detailL'électroneuromyographie dans la pathologie de la face dorsale du pied
WANG, François-Charles ULg

in Médecine et Chirurgie du Pied = Foot Medicine and Surgery (2014), (30), 86-89

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See detailTeaching conservation-restoration in an art school: sharing expériences
Verbeeck, Muriel ULg; Breuil, Marie-Hélène

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2014)

Teaching conservation-restoration in an art school can be considered a blessing as well as a challenge: What is the position of a conservator-restorator in this environment? What are the relationships ... [more ▼]

Teaching conservation-restoration in an art school can be considered a blessing as well as a challenge: What is the position of a conservator-restorator in this environment? What are the relationships between art conservation and creation, creation and technique? What legitimises research in conservation-restoration, scientific or applied, in this context? This paper, based on our teaching experiences in France and in Belgium reveals a field of expertise and the necessity of understanding the processes of art creation holistically. [less ▲]

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See detailThe evaluation of vocal pitch accuracy: The case of operatic singing voices
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Music Perception (2014), 32(1), 1-10

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices ... [more ▼]

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices, which have particularly complex acoustical signals. Twenty-two music experts were asked to evaluate the vocal pitch accuracy of 14 sung performances with a pairwise comparison paradigm, in a test and a retest. In addition to the objective measurement of pitch accuracy (pitch interval deviation), several performance parameters (average tempo, fundamental frequency of the starting note) and quality parameters (energy distribution, vibrato rate and extent) were observed and compared to the judges’ perceptual rating. The results show high intra- and inter-judge reliability when rating the pitch accuracy of operatic singing voices. Surprisingly, all the parameters were significantly related to the ratings and explain 78.8% of the variability of the judges’ rating. The pitch accuracy evaluation of operatic voices is thus not based exclusively on the precision of performed music intervals but on a complex combination of performance and quality parameters. [less ▲]

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See detailPEGylation of antibody fragments greatly increases their local residence time following delivery to the respiratory tract.
Koussoroplis, Salome Juliette; Paulissen, Geneviève ULg; Tyteca, Donatienne et al

in Journal of Controlled Release (2014), sous presse

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The ... [more ▼]

Inhalation aerosols offer a targeted therapy for respiratory diseases. However, the therapeutic efficacy of inhaled biopharmaceuticals is limited by the rapid clearance of macromolecules in the lungs. The aim of this research was to study the effects of the PEGylation of antibody fragments on their local residence time after administration to the respiratory tract. We demonstrate that the conjugation of a two-armed 40-kDa polyethylene glycol (PEG) chain to anti-interleukin-17A (IL-17A) F(ab')2 and anti-IL-13 Fab' greatly prolonged the presence of these fragments within the lungs of mice. The content of PEGylated antibody fragments within the lungs plateaued up to 4hours post-delivery, whereas clearance of unconjugated proteins started immediately after administration. Forty-eight hours post-delivery, F(ab')2 and Fab' content in the lungs had decreased to 10 and 14 % of the dose initially deposited, respectively. However, this value was 40 % for both PEG40-F(ab')2 and PEG40-Fab'. The prolonged pulmonary residency of the anti-IL-17A PEG40-F(ab')2 translated into an improved efficacy in reducing lung inflammation in a murine model of house dust mite-induced lung inflammation. We demonstrate that PEGylated proteins were principally retained within the lung lumen rather than the nasal cavities or lung parenchyma. In addition, we report that PEG increased pulmonary retention of antibody fragments through mucoadhesion and escape from alveolar macrophages rather than increased hydrodynamic size or improved enzymatic stability. The PEGylation of proteins might find broad application in the local delivery of therapeutic proteins to diseased airways. [less ▲]

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See detailWhat factors determine Belgian general practitioners' approaches to detecting and managing substance abuse? A qualitative study based on the I-Change Model.
Ketterer, Frédéric ULg; Symons, Linda; Lambrechts, Marie-Claire et al

in BMC Family Practice (2014), 15(1), 119

BACKGROUND: General practitioners (GPs) are considered to play a major role in detecting and managing substance abuse. However, little is known about how or why they decide to manage it. This study ... [more ▼]

BACKGROUND: General practitioners (GPs) are considered to play a major role in detecting and managing substance abuse. However, little is known about how or why they decide to manage it. This study investigated the factors that influence GP behaviours with regard to the abuse of alcohol, illegal drugs, hypnotics, and tranquilisers among working Belgians. METHODS: Twenty Belgian GPs were interviewed. De Vries' Integrated Change Model was used to guide the interviews and qualitative data analyses. RESULTS: GPs perceived higher levels of substance abuse in urban locations and among lower socioeconomic groups. Guidelines, if they existed, were primarily used in Flanders. Specific training was unevenly applied but considered useful. GPs who accepted abuse management cited strong interpersonal skills and available multidisciplinary networks as facilitators.GPs relied on their clinical common sense to detect abuse or initiate management. Specific patients' situations and their social, psychological, or professional dysfunctions were cited as cues to action.GPs were strongly influenced by their personal representations of abuse, which included the balance between their professional responsibilities toward their patients and the patients' responsibilities in managing their own health as well the GPs' abilities to cope with unsatisfying patient outcomes without reaching professional exhaustion. GPs perceived substance abuse along a continuum ranging from a chronic disease (whose management was part of their responsibility) to a moral failing of untrustworthy people. Alcohol and cannabis were more socially acceptable than other drugs. Personal experiences of emotional burdens (including those regarding substance abuse) increased feelings of empathy or rejection toward patients.Multidisciplinary practices and professional experiences were cited as important factors with regard to engaging GPs in substance abuse management. Time constraints and personal investments were cited as important barriers.Satisfaction with treatment was rare. CONCLUSIONS: Motivational factors, including subjective beliefs not supported by the literature, were central in deciding whether to manage cases of substance abuse. A lack of theoretical knowledge and training were secondary to personal attitudes and motivation. Personal development, emotional health, self-awareness, and self-care should be taught to and fostered among GPs to help them maintain a patient-centred focus. Health authorities should support collaborative care. [less ▲]

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See detailUn monde entre accélération et incertitudes
Santander, Sébastian ULg

in Interventions Economiques = Papers in Political Economy (2014)

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See detailWhich incretin-based therapy for type 2 diabetes?
Scheen, André ULg

in Lancet (2014)

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See detailL'inhibition des voies de signalisation est-elle une possibilité thérapeutique pour l'arthrose?
Henrotin, Yves ULg

in Revue du Rhumatisme (2014)

Les voies de signalisation sont des cibles intéressantes pour les traitements de l’arthrose car leur inhibition ou leur activation permet de réguler l’expression d’un ensemble de gènes cibles directement ... [more ▼]

Les voies de signalisation sont des cibles intéressantes pour les traitements de l’arthrose car leur inhibition ou leur activation permet de réguler l’expression d’un ensemble de gènes cibles directement impliqués dans le dysfonctionnement métabolique des tissus articulaires. Cependant, les premiers essais cliniques réalisés dans la PR ont montré que la régulation spécifique de la voie JAK/STAT induit de nombreux effets secondaires. Ce point pourrait être un facteur limitant l’utilisation d’inhibiteurs ou d’activateurs spécifiques des voies de signalisation dans l’arthrose. Dans cette maladie, le rapport risque/bénéfice doit rester le facteur clé de la décision thérapeutique, car il s’agit de traiter une maladie d’évolution lente, de sévérité modérée et associée à de nombreuses comorbidités. [less ▲]

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See detailAUTOMATISATION DE LA DÉTECTION DES CRATÈRES LUNAIRES SUR DES IMAGES ET MNT PLANÉTAIRES
Renson, Pierre; Poncelet, Nadia; Vandeloise, Yannick et al

in Bulletin de la Société Géographique de Liège (2014), 61

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images ... [more ▼]

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images and DTM). In this context, the automation of the process is essential because the craters represent a landing risk and landmarks for visual navigation. It is also the key challenge because it is difficult to develop high level automatic processing comparable to the thinking carried out in a traditional visual interpretation. Our method automatically establishes a semantic diagnosis based on the combination of crater descriptors computed on the planetary products used. Finally, this application is part of a decision support tool and an assessment system of landing and mission survival risks. It also aims to feed a landmarks database for automatic visual navigation of a lunar landing spacecraft. [less ▲]

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See detailMapping Diasporic Subjectivities
Munos, Delphine ULg; Pandurang, Mala

in South Asian Diaspora (2014), 6(1),

The last two decades have witnessed a growing interest in theorizing literary narratives that address the South Asian diasporic experience. By and large, however, what has emerged is an academic consensus ... [more ▼]

The last two decades have witnessed a growing interest in theorizing literary narratives that address the South Asian diasporic experience. By and large, however, what has emerged is an academic consensus which accords an ever-greater visibility to mainstream diasporic voices from North America, U.K., some parts of Africa and of the Caribbean, at the expense of narratives dealing with South Asian diasporic communities that are based in other locations. Also, such critical consensus valorizes certain class-streamed patterns of migration over others, with the result of homogenizing the diversity of today’s South Asian diaspora. This special issue explores literary representations of the migrant experiences of those underrepresented South Asian communities based in locations such as South America, East Europe, the Gulf, West Africa and East Asia. [less ▲]

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See detailSurprising causes of C5-carnitine false positive results in newborn screening.
BOEMER, François ULg; SCHOOS, Roland ULg; de HALLEUX, Virginie ULg et al

in Molecular genetics and metabolism (2014), 111(1), 52-4

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we ... [more ▼]

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we confirmed the presence of pivaloylcarnitine. Exogenous pivalate administration had been previously identified as the causal agent of this concern. No pivalic-ester prodrug is commercially available in Belgium, but pivalic derivates are also used in the cosmetic industry as emollient under the term "neopentanoate". We have identified neopentanoate-esters in a nipple-fissure unguent that was provided to young mothers. Ceasing distribution of this product hugely reduced the C5-carnitine false positivity rate. [less ▲]

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See detailCyanoacrylate skin surface strippings and the 3S-Bioket advent in tropical dermatology. A look from Liège.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; PAQUET, Philippe ULg et al

in Scientific World Journal (The) (2014), 2014

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named ... [more ▼]

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named skin surface biopsy or follicular biopsy, represents a convenient low cost procedure. It is a minimally invasive method collecting a continuous sheet of stratum corneum and horny follicular casts. In the vast majority of cases, it is painless and is unassociated with adverse events. CSSS can be performed in subjects of any age. The method has a number of applications in diagnostic dermatopathology and cosmetology, as well as in experimental dermatology settings. A series of derived analytic procedures include xerosis grading, comedometry, corneofungimetry, corneodynamics of stratum corneum renewal, corneomelametry, corneosurfametry, and corneoxenometry. [less ▲]

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