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See detailInsights into abundant rumen ureolytic bacterial community using rumen simulation system
Jin, Di; Zhao, Shengguo; Wang, Pengpeng et al

in Frontiers in Microbiology (2016), 7(1006),

Urea, a non-protein nitrogen for dairy cows, is rapidly hydrolyzed to ammonia by urease produced by ureolytic bacteria in the rumen, and the ammonia is used as nitrogen for rumen bacterial growth. However ... [more ▼]

Urea, a non-protein nitrogen for dairy cows, is rapidly hydrolyzed to ammonia by urease produced by ureolytic bacteria in the rumen, and the ammonia is used as nitrogen for rumen bacterial growth. However, there is limited knowledge with regard to the ureolytic bacteria community in the rumen. To explore the ruminal ureolytic bacterial community, urea, or acetohydroxamic acid (AHA, an inhibitor of urea hydrolysis) were supplemented into the rumen simulation systems. The bacterial 16S rRNA genes were sequenced by Miseq high-throughput sequencing and used to reveal the ureoltyic bacteria by comparing different treatments. The results revealed that urea supplementation significantly increased the ammonia concentration, and AHA addition inhibited urea hydrolysis. Urea supplementation significantly increased the richness of bacterial community and the proportion of ureC genes. The composition of bacterial community following urea or AHA supplementation showed no significant difference compared to the groups without supplementation. The abundance of Bacillus and unclassified Succinivibrionaceae increased significantly following urea supplementation. Pseudomonas, Haemophilus, Neisseria, Streptococcus, and Actinomyces exhibited a positive response to urea supplementation and a negative response to AHA addition. Results retrieved from the NCBI protein database and publications confirmed that the representative bacteria in these genera mentioned above had urease genes or urease activities. Therefore, the rumen ureolytic bacteria were abundant in the genera of Pseudomonas, Haemophilus, Neisseria, Streptococcus, Actinomyces, Bacillus, and unclassified Succinivibrionaceae. Insights into abundant rumen ureolytic bacteria provide the regulation targets to mitigate urea hydrolysis and increase efficiency of urea nitrogen utilization in ruminants. [less ▲]

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See detailComposite joints under M-N at elevated temperatures
Haremza, Cécile; Santiago, Aldina; Demonceau, Jean-François ULg et al

in Journal of Constructional Steel Research (2016), 124

The Eurocodes recognise robustness as a way to ensure the structural integrity of a building frame subjected to an unforeseen event and therefore to avoid a so-called “progressive failure” mode in extreme ... [more ▼]

The Eurocodes recognise robustness as a way to ensure the structural integrity of a building frame subjected to an unforeseen event and therefore to avoid a so-called “progressive failure” mode in extreme loading situations. However, few practical guidelines exist nowadays which would allow a designer to design a structure accordingly. Within the European RFCS ROBUSTFIRE project, the behaviour of steel and composite car parks subjected to localised fire leading to a column loss was investigated. Under such a scenario, the beam-to-column joints play a key role in the global structural response. Indeed, these joints, initially loaded in bending, may be subjected to elevated temperatures and to combined axial load “N”, bending moment “M” and shear forces “V”. In this paper, a methodology to predict the mechanical response of bolted composite beam-to-column joints at elevated temperatures under M-N is presented and validated through comparison with detailed numerical results and experimental tests. This methodology is based on an analytical method able to predict M-N resistance interaction curves for steel and composite joints and which is in full agreement with the component model recommended by the Eurocode. [less ▲]

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See detailBrabantophyton, a new genus with stenokolealean affinities from a Middle to earliest Upper Devonian locality from Belgium
Momont, Nicolas ULg; Gerrienne, Philippe ULg; Prestianni, Cyrille

in Review of Palaeobotany and Palynology (2016)

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late ... [more ▼]

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late Middle to earliest Upper Devonian) locality of Ronquières (Belgium). The specimens include stems and lateral organs. The stems are characterized by a protostele dissected into three primary ribs, each of them dividing into two secondary ribs. The protostele shows a central protoxylem strand and numerous strands distributed along the midplanes of the ribs. The vascular supply to lateral organ is composed of two pairs of traces, produced at the same time by the two ribs issued from a single primary rib of the protostele. Within each pair, the shape and the size of the traces are unequal: one is T-shaped and the other is oval to reniform. The T-shaped traces of each pair face each other. The inner cortex of the lateral organs is parenchymatous and the outer cortex is sparganum-like. The specimens of Brabantophyton runcariense show many similarities with the stenokolealean genus Crossia virginiana Beck and Stein, but the vascular supply of lateral organs of the latter consists of a more symmetrical and distinctively simpler pair of traces. Brabantophyton represents the first report of the Stenokoleales in southeastern Laurussia. The characteristics of the Brabantophyton protostele compare better with the anatomy of the radiatopses, and, within the latter, particularly with basal seed plants. [less ▲]

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See detailIL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis.
Humblet-Baron, Stephanie; Franckaert, Dean; Dooley, James et al

in Journal of Allergy and Clinical Immunology (The) (2016), 138(1), 200-2098

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic ... [more ▼]

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8(+) T-cell activation. HLH occurs as both acquired and familial hemophagocytic lymphohistiocytosis (FHL) forms. In both conditions, a sterile or infectious trigger is required for disease initiation, which then becomes self-sustaining and life-threatening. Recent studies have attributed the key distal event to excessive IFN-gamma production; however, the proximal events driving immune dysregulation have remained undefined. OBJECTIVE: We sought to investigate the role of regulatory T (Treg) cells in the pathophysiology of experimental FHL. METHODS: Because mutation in perforin is a common cause of FHL, we used an experimental FHL mouse model in which disease in perforin-deficient mice is triggered by lymphocytic choriomeningitis virus (LCMV). We assessed Treg and CD8(+) T-cell homeostasis and activation during the changing systemic conditions in the mice. In addition, human blood samples were collected and analyzed during the HLH episode. RESULTS: We found no primary Treg cell defects in perforin-deficient mice. However, Treg cell numbers collapsed after LCMV inoculation. The collapse of Treg cell numbers in LCMV-triggered perforin-deficient, but not wild-type, mice was accompanied by the combination of lower IL-2 secretion by conventional CD4(+) T cells, increased IL-2 consumption by activated CD8(+) T cells, and secretion of competitive soluble CD25. Moreover low Treg cell numbers were observed in untreated patients experiencing HLH flares. CONCLUSION: These results demonstrate that excessive CD8(+) T-cell activation rewires the IL-2 homeostatic network away from Treg cell maintenance and toward feed-forward inflammation. These results also provide a potential mechanistic pathway for the progression of infectious inflammation to persistent inflammation in patients with HLH. [less ▲]

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See detailLa correction de l’expression écrite en langue étrangère et son exploitation pédagogique. Expliciter l’implicite ?
Noiroux, Kevin ULg; Simons, Germain ULg

in Les cahiers de l’Association des chercheurs et enseignants didacticiens des langues étrangères (acedle) (2016)

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See detailThe on-pump/off-pump saga: an enduring conundrum.
Sousa Uva, Miguel; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(4), 1042-3

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See detailSuitability of soils and river deposits from Marrakech for the manufacturing of earthenware
El Boudour El Idrissi, Hicham ULg; Daoudi, Lahcen; El Ouahabi, Meriam ULg et al

in Applied Clay Science (2016), 129

This paper investigates the suitability of clayey materials originating from semi-arid soil and river sediments, used by potters in the Agafay region for the manufacture of ceramic products. The clay ... [more ▼]

This paper investigates the suitability of clayey materials originating from semi-arid soil and river sediments, used by potters in the Agafay region for the manufacture of ceramic products. The clay samples were subjected to particle-size analysis, X-ray diffraction and X-ray fluorescence to investigate their physical, mineralogical and chemical characteristics respectively. The physical behaviour of the intermediate products was studied at the shaping and drying stages of the ceramics manufacturing process through the Atterberg limits and the plot of the Bigot curve respectively. The final product characteristics were determined through porosity tests, flexural and compressive strengths tests. Based on results obtained, the raw materials turn out to be suitable characteristics for the manufacture of earthenware products. The application of the suggested recommendations is worthy for the improvement of the products based on such raw materials. [less ▲]

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See detailInvestigation of a suitable in vitro dissolution test for itraconazole-based solid dispersions
Thiry, Justine ULg; Broze, Guy ULg; Pestieau, Aude ULg et al

in European Journal of Pharmaceutical Sciences (2016)

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See detailMaximum Entropy Kernels for System Identification
Carli, Francesca Paola ULg; Chen, Tianshi; Ljung, Lennart

in IEEE Transactions on Automatic Control (2016)

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See detailReflectometry with an open-source Software GNSS Receiver. Use Cases with Carrier Phase Altimetry.
Lestarquit, Laurent; Peyrezabes, Mathieu; Darrozes, José et al

in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2016)

An open-source GNSS software receiver allows to have full access to the signal processing and to make add-ons to the source code in order to obtain the desired GNSS reflectometry processing. The direct ... [more ▼]

An open-source GNSS software receiver allows to have full access to the signal processing and to make add-ons to the source code in order to obtain the desired GNSS reflectometry processing. The direct signal is processed in the standard way, its tracking loops replica are tapped to have a robust processing of the reflected signal in a master-slave configuration, with the very same carrier replica used to correlate the reflected signal. Additionally, the data bit sign is wiped off, which allows to extend the coherent integration time (CIT) well beyond the usual 20 milliseconds limit on the reflected way. This allows having a straightforward and accurate measurement of the Amplitude Ratio and Differential Carrier Phase between the direct and reflected signal. The possible applications are precise carrier phase altimetry and any application requiring signal amplitude ratio, or reflected signal Delay Map, with single or dual polarization, this includes code altimetry, humidity, biomass, soil roughness, ocean surface wind and wave height, snow and ice characteristics retrieval. This software is intended to be used as a research tool. It has been tested for carrier phase altimetry on real data sets collected in rather calm water conditions: at the 60 meter Cordouan Lighthouse, and during a 600 meter high ATR42 flight over a lake. In both case, continuous carrier phase measurement with a centimeter level precision were obtained when extending the CIT up to 500 ms. Increasing the CIT beyond 20 ms is the key to improve carrier phase altimetry robustness. [less ▲]

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See detailTypus melancholicus et mélancolie: synthèse théorique à partir d'un cas clinique
Englebert, Jérôme ULg; Stanghellini, Giovanni

in Encéphale (L') (2016), 42(1), 105-111

Objective: The objective of this paper is to propose, starting from the description of a clinical emblematic case, a theoretical synthesis of the work of phenomenological psychopathology dedicated to ... [more ▼]

Objective: The objective of this paper is to propose, starting from the description of a clinical emblematic case, a theoretical synthesis of the work of phenomenological psychopathology dedicated to melancholia and typus melancholicus (TM), a clinical concept that describes the premorbid personality vulnerable to major depression (“melancholia” for the psychopathological tradition). Method: This is phenomenological analysis of a case study of melancolia, of its premorbid personality and pathogenic triggering situation. We adopt two main phenomenological keys to understanding the develpment of melancholia : role-identity theory and desynchronization theory. The former understands melancholia as a disorder of identity triggered by the loss of the social role with which one has previously over-identifed. The latter sees melancholia as the effect of the desynchronisation from the social environment that further develops into an inhibition of the conative–affective dynamics of life. We present the case of Jonas (64 years old), whose mother (94 years old) recently died. Before his mother’s death, Jonas’ life was entirely orchestrated by the caring for his mother and synchronized in time with this (e.g., he used to go to her house every 4 hours, took all his meals with her, etc.). Jonas, in addition to being hyper-synchronized and hyper-syntonic, fulfills all diagnostic criteria for TM, including “orderliness”, “conscientiousness”, “hyper/heteronomia” and “intolerance of ambiguity”. TM’s attach a disproportioned importance to their social roles (or external representations of identity) at the expense of their own ego-identity. Results: The passage from pre-morbid personality to melancholia is triggered by the death of Jonas’ mother that entails a profound depersonalization. Desynchronization and role loss cause Jonas fall into this severe depersonalization, whose core feature is the feeling of the loss of feeling. Conclusions: This original contribution demonstrates a clinical case can contribute to the construction and refinement of theoretical and conceptual frameworks (like princeps Tellenbach's studies). Over-synchronized tempo and over-identification with social role are emblematically in this case the two sides of the same coin. A parallelism can be established between synchronization (with the mother) and respect for the role at the expense of own identity. The clinical case of Jonas highlights a conceptual bridge between the model of melancholia as loss of social role and the model of melancholia as desynchronization. [less ▲]

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See detailAmide proton transfer (APT) imaging of brain tumors at 7 T: The role of tissue water T -Relaxation properties.
Khlebnikov, Vitaliy; Polders, Daniel; Hendrikse, Jeroen et al

in Magnetic resonance in medicine (2016)

PURPOSE: To provide insight into the effect of water T1 relaxation (T1wat ) on amide proton transfer (APT) contrast in tumors. Three different metrics of APT contrast-magnetization transfer ratio (MTRRex ... [more ▼]

PURPOSE: To provide insight into the effect of water T1 relaxation (T1wat ) on amide proton transfer (APT) contrast in tumors. Three different metrics of APT contrast-magnetization transfer ratio (MTRRex ), relaxation-compensated MTRRex (AREX), and traditional asymmetry (MTRasym )-were compared in normal and tumor tissues in a variety of intracranial tumors at 7 Tesla (T). METHODS: Six consented intracranial tumor patients were scanned using a low-power, three-dimensional (3D) APT imaging sequence. MTRRex and MTRasym were calculated in the region of 3 to 4 ppm. AREX was calculated by T1wat correction of MTRRex . Tumor tissue masks, which classify different tumor tissues, were drawn by an experienced neuroradiologist. ROI-averaged tumor tissue analysis was done for MTRRex , AREX, and MTRasym . RESULTS: MTRRex and MTRasym were slightly elevated in tumor-associated structures. Both metrics were positively correlated to T1wat . The correlation coefficient (R) was determined to be 0.88 (P < 0.05) and 0.92 (P << 0.05) for MTRRex and MTRasym , respectively. After T1wat correction (R = -0.21, P = 0.69), no difference between normal and tumor tissues was found for AREX. CONCLUSIONS: The strong correlation of MTRRex and MTRasym with T1wat and the absence thereof in AREX suggests that much of APT contrast in tumors for the low-power, 3D-acquisition scheme at 7 T originates from the inherent tissue water T1 -relaxation properties. Magn Reson Med, 2016. (c) 2016 Wiley Periodicals, Inc. [less ▲]

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See detailComment je traite ....... Le delirium chez le patient âgé
CHRISTELBACH, Sophie ULg; ALLEPAERTS, Sophie ULg; PETERMANS, Jean ULg

in Revue Médicale de Liège (2016)

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See detailMitochondrial function is altered in horse atypical myopathy
Lemieux, Hélène; BOEMER, François ULg; van Galen, Gaby et al

in Mitochondrion (2016), 30

Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus. The hallmark of atypical ... [more ▼]

Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus. The hallmark of atypical myopathy consists of a severe alteration in the energy metabolism including a severe impairment in muscle mitochondrial respiration that could contribute to its high death rate [less ▲]

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See detailEffects of planting methods and tuber weights on growth and yield of yam cultivars (Dioscorea rotundata Poir.) in Gabon
ONDO OVONO, Paul; Kevers, Claire ULg; Dommes, Jacques ULg

in International Research Journal of Agricultural Science and soil Science (2016), 6

A study was conducted to investigate the influence of planting methods and tuber weight on growth and yield of local yam cultivars obtained by the minisett technique from white yam (D. rotundata) in Gabon ... [more ▼]

A study was conducted to investigate the influence of planting methods and tuber weight on growth and yield of local yam cultivars obtained by the minisett technique from white yam (D. rotundata) in Gabon. Trials were carried out in 2014 and 2015 at the experimental ground of the Higher National Institute of Agronomy and Biotechnology, under natural conditions of lightness, temperature and relative humidity. Twenty- four weeks old mini tubers obtained from local cultivar MVA of D. rotundata were harvested, weighed and categorized ( 40-80 g; 100-150 g; 200-300 g), and three planting methods (horizontal, oblique and vertical), arranged in ridges constituted the main factors. The experiment was laid out in Randomized Completely Block Design with eighteen treatments and two replications. Data pertaining to sprouting were recorded for 30, 60, 90 and 180 DAP, for tuber length (cm), tuber weight (Kg) and number of tubers per plant 270 DAP. Significant differences among tuber weight in all variables tested were observed. The larger tubers had better sprouting ability than the rest of the tuber weight. The methods of planting had no effects on yield and its components but they affect the depth and spread of tubers. Vertical planting produced deeper but more compactly arranged tubers while horizontal planting produced tubers which were shallower but more widespread. Slanting was intermediate for both depth and spread. The number and weight of tubers obtained from mini tubers planted out according to slanting method were significantly different (P< 0.05) from other planting methods. The production of seedlings from mini tuber is an improvement of traditional production of seed yam. Mini tubers must have at least 100-300 g and they should be planted slanting or vertically. [less ▲]

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See detailConvective drying of cherry tomato: Study of skin effect
Khama, Reda; Aissani, F.; Alkama, R. et al

in Journal of Engineering Science and Technology (2016), 11(3), 443-457

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See detailBiotic homogenization can decrease landscape-scale forest multifunctionality
van der Plas, Fons; Manning, Pete; Soliveres, Santiago et al

in Proceedings of the National Academy of Sciences (2016), 113(13), 3557-62

Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of ... [more ▼]

Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of biodiversity in driving ecosystem multifunctionality at landscape scales remains unresolved. We used a comprehensive pan-European dataset, including 16 ecosystem functions measured in 209 forest plots across six European countries, and performed simulations to investigate how local plot-scale richness of tree species (α-diversity) and their turnover between plots (β-diversity) are related to landscape-scale multifunctionality. After accounting for variation in environmental conditions, we found that relationships between α-diversity and landscape-scale multifunctionality varied from positive to negative depending on the multifunctionality metric used. In contrast, when significant, relationships between β-diversity and landscape-scale multifunctionality were always positive, because a high spatial turnover in species composition was closely related to a high spatial turnover in functions that were supported at high levels. Our findings have major implications for forest management and indicate that biotic homogenization can have previously unrecognized and negative consequences for large-scale ecosystem multifunctionality. [less ▲]

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See detailCompte-rendu de l'ouvrage Cluny. Les moines et la société au premier age féodal
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

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See detailProjecting the self into the future in individuals with schizophrenia: a preliminary cross-sectional study.
Raffard, Stephane; Bortolon, Catherine; D'Argembeau, Arnaud ULg et al

in Memory (2016), 24(6), 826-837

The ability to project oneself into the future contributes to development and maintenance of a coherent sense of identity. If recent research has revealed that schizophrenia is associated with ... [more ▼]

The ability to project oneself into the future contributes to development and maintenance of a coherent sense of identity. If recent research has revealed that schizophrenia is associated with difficulties envisioning the future, little is known about patients' future self-representations. In this study, 27 participants with schizophrenia and 26 healthy controls were asked to simulate mental representations of plausible and highly significant future events (self-defining future projections, SDFPs) that they anticipate to happen in their personal future. Main results showed that schizophrenia patients had difficulties in reflecting on the broader meaning and implications of imagined future events. In addition, and contrary to our hypothesis, a large majority of SDFPs in schizophrenia patients were positive events, including achievements, relationship, and leisure contents. Interestingly, patients and controls did not differ on the perceived probability that these events will occur in the future. Our results suggest that schizophrenia patients have an exaggerated positive perception of their future selves. Together, these findings lend support to the idea that past and future self-defining representations have both similar and distinct characteristics in schizophrenia. [less ▲]

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See detailInfluence of promoters on the production of fengycin in Bacillus spp.
Yasseen, Y.; Gancel, F.; Drider, D. et al

in Research in Microbiology (2016), 167

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See detailIn vitro screening of mare's milk antimicrobial effect and antiproliverative activity.
Guri, Anilda; Paligot, Michèle; Crevecoeur, Sébastien ULg et al

in FEMS Microbiology Letters (2016)

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See detailMeningitis and orchitis in a hare (Lepus Europaeus) infected with Francisella tularensis
Grégoire, Fabien; Cassart, Dominique ULg; Desmecht, Daniel ULg et al

in Veterinary Records Case Reports (2016), 4(e000306),

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See detailInterobserver agreement for the ATS/ERS/JRS/ALAT criteria for a UIP pattern on CT.
Walsh, Simon L. F.; Calandriello, Lucio; Sverzellati, Nicola et al

in Thorax (2016), 71(1), 45-51

OBJECTIVES: To establish the level of observer variation for the current ATS/ERS/JRS/ALAT criteria for a diagnosis of usual interstitial pneumonia (UIP) on CT among a large group of thoracic radiologists ... [more ▼]

OBJECTIVES: To establish the level of observer variation for the current ATS/ERS/JRS/ALAT criteria for a diagnosis of usual interstitial pneumonia (UIP) on CT among a large group of thoracic radiologists of varying levels of experience. MATERIALS AND METHODS: 112 observers (96 of whom were thoracic radiologists) categorised CTs of 150 consecutive patients with fibrotic lung disease using the ATS/ERS/JRS/ALAT CT criteria for a UIP pattern (3 categories--UIP, possibly UIP and inconsistent with UIP). The presence of honeycombing, traction bronchiectasis and emphysema was also scored using a 3-point scale (definitely present, possibly present, absent). Observer agreement for the UIP categorisation and for the 3 CT patterns in the entAUe observer group and in subgroups stratified by observer experience, were evaluated. RESULTS: Interobserver agreement across the diagnosis category scores among the 112 observers was moderate, ranging from 0.48 (IQR 0.18) for general radiologists to 0.52 (IQR 0.20) for thoracic radiologists of 10-20 years' experience. A binary score for UIP versus possible or inconsistent with UIP was examined. Observer agreement for this binary score was only moderate. No significant differences in agreement levels were identified when the CTs were stratified according to multidisciplinary team (MDT) diagnosis or patient age or when observers were categorised according to experience. Observer agreement for each of honeycombing, traction bronchiectasis and emphysema were 0.59+/-0.12, 0.42+/-0.15 and 0.43+/-0.18, respectively. CONCLUSIONS: Interobserver agreement for the current ATS/ERS/JRS/ALAT CT criteria for UIP is only moderate among thoracic radiologists, AUrespective of theAU experience, and did not vary with patient age or the MDT diagnosis. [less ▲]

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See detailReview of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014
Comblain, Fanny ULg; Serisier, Samuel; Barthelemy, Nicolas ULg et al

in Journal of Veterinary Pharmacology & Therapeutics (2016), 39

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See detailTemperature and moisture storage in crop-based materials: Modelling a straw bale wall subject to a thermal shock
Dubois, Samuel ULg; Evrard, Arnaud ULg; Blecker, Christophe ULg et al

in Jounal of Building Physics (2016)

Modelling the hygrothermal behaviour of crop-based insulation products is essential to assess their impact on the energy performance of the building, predict indoor climate conditions, and prevent any ... [more ▼]

Modelling the hygrothermal behaviour of crop-based insulation products is essential to assess their impact on the energy performance of the building, predict indoor climate conditions, and prevent any risk of unexpected degradation. Traditionally, transient numerical models that predict internal conditions of construction materials consider that the variation of moisture storage with temperature is negligible although the sorp- tion behaviour is known to be temperature dependent. This paper investigates this par- ticular effect for crop-based materials and uses a refinement of standard mathematical representations. For this purpose, the effects of a thermal shock on the evolution of hygrothermal conditions inside a straw-bale wall are studied with several versions of a flexible research model. The latter is capable of incorporating the temperature depen- dency of the sorption curve with both a physically-based and an empirical description. A large climate chamber is used to gather experimental data and is able to host a full- size straw bale prefabricated panel. Internal conditions of straw bales are obtained with proper sensors bars. Results show that when large temperature gradients occur in a crop-based material, a model that considers temperature effect on moisture storage enhances greatly the prediction of internal conditions. [less ▲]

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See detailPositive Operations on Wastewater Sludge Drying: Comparison of Back-Mixing and Sawdust Addition
Li, Jie; Plougonven, Erwan ULg; Fraikin, Laurent ULg et al

in Energy & Fuels (2016), 30(4), 3014-3019

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See detailBox search for the data mining of the key parameters of an industrial process
Louveaux, Quentin ULg; Mathei, Axel; Mathieu, Sébastien ULg

in Intelligent Data Analysis (2016), 20(6),

To increase their competitiveness, many industrial companies monitor their production process, collecting large amount of measurements. This paper describes a technique using this data to improve the ... [more ▼]

To increase their competitiveness, many industrial companies monitor their production process, collecting large amount of measurements. This paper describes a technique using this data to improve the performance of a monitored process. In particular we wish to find a set of rules, i.e. intervals on a reduced number of parameters, for which an output value is maximized. The model-free optimization problem to solve is to find a box, restricted on a limited amount of dimensions, with the maximum mean value of the included points. This article compares a machine learning-based heuristic to the solution computed by a mixed-integer linear program on real-life databases from steel and glass manufacturing. Computational results show that the heuristic obtains comparable solutions to the mixed integer linear approach. However, the exact approach is computationally too expensive to tackle real life databases. Results show that the restriction of five process parameters, on these databases, may improve the quality of the process by 50%. [less ▲]

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See detailFirst-Principles Study of the Thermoelectric Properties of SrRuO3
Miao, Naihua; Xu, Bin ULg; Bristowe, Nicholas ULg et al

in Journal of Physical Chemistry (2016), 120

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See detailVers un modèle d’apprentissage réflexif. Recueil de traces d’apprentissage formulées dans les log books des stagiaires en médecine
Vierset, Viviane ULg

in Approches Inductives : Travail Intellectuel et Construction des Connaissances (2016)

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See detailExperimental study of an oil-free steam piston expander for micro-combined heat and power systems
Bouvier, Jean-Louis; Lemort, Vincent ULg; Michaux, Ghislain et al

in Applied Energy (2016), 1 69

This paper presents an experimental study conducted on an oil-free steam piston expander for micro combined heat and power systems. This expander can produce electrical power (between 740 and 2400 W) with ... [more ▼]

This paper presents an experimental study conducted on an oil-free steam piston expander for micro combined heat and power systems. This expander can produce electrical power (between 740 and 2400 W) with a significant range of supply temperature (between 260 and 340 C) and pressure (between 20 and 34 bar). The expander electrical power output exhibits a fast dynamic response to a change of working or supply fluid conditions. The reached expander overall isentropic efficiency (including electrical generator efficiency) was between 19% and 40%. An empirical model has been developed in order to conduct a sensitivity analysis of the system by varying working variables such as supply and exhaust pressures, rotational speed and supply temperature. The parameters of this model have been identified using experimental results. The sensitivity analysis showed a limited increase of the electrical power output with a rotational speed until 900 rpm and a reduction of the power output for values beyond 900 rpm. It also highlighted the significant positive impact of the supply pressure on the electrical power output and the negative impact of the superheating on the expander overall isentropic efficiency. The obtained results are useful for the future control of the expander integrated into a Rankine cycle. Since the fluid at the expander exhaust is steam at a pressure close to 1 bar, it is possible to produce heat at a temperature close to 80 C, which is sufficient for most domestic applications (heating or direct hot water production). [less ▲]

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See detailNew Insight on the Performance of Equity Long/short Investment Styles
Fays, Boris ULg; Hübner, Georges ULg; Lambert, Marie ULg

in Bankers, Markets, Investors (2016), 140(January-February), 34-45

Long-short equity strategies have recently generated exceptional performance raising a set of concerns about the strategies’ propensity to deliver alpha or beta. This paper revisits the performance of ... [more ▼]

Long-short equity strategies have recently generated exceptional performance raising a set of concerns about the strategies’ propensity to deliver alpha or beta. This paper revisits the performance of equity long-short hedge funds across investments styles. We first categorize individual hedge funds with regard to their size and/or value factor investing along the generalization of Sharpe (1992) style analysis. Style weights on size and value factors are used to split the equity long-short universe in 5x5 hedge fund style portfolios. To analyze the performance of each style, we consider two sets of innovative factors. First, we apply sequential Fama-French model of Lambert, Fays and Hübner (2015). Besides, to captures downside and extreme risk embedded in hedge fund strategies we augment the model with the co-skewness and co-kurtosis factors developed by Lambert and Hübner (2013). Under this framework, we perform cross-sectional performance analyses of individual hedge funds as well as time-series analysis on the hedge fund style broad category. Our contributions are threefold; first, our alternative framework significantly improves the explanatory power of the multi-factor model in the context of long-short equity funds, second, considering higher-moment factors aim to capture part of the abnormal return of the downside and extreme risk exposures taken by a fund manager, and finally, long-short equity hedge funds are, to some extent, less exposed to small capitalisation stocks than expected and instead rather prefer higher momentum levels in their strategies. [less ▲]

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See detailImpact of injection solvent composition on protein identification incolumn-switching chip-liquid chromatography/mass spectrometry
Houbart, Virginie ULg; COBRAIVILLE, Gaël ULg; Nys, Gwenaël ULg et al

in Journal of Chromatography. A (2016), 1445

In shotgun proteomics, the gold standard technique is reversed-phase liquid chromatography coupledto mass spectrometry. Many researches have been carried out to study the effects on identification per ... [more ▼]

In shotgun proteomics, the gold standard technique is reversed-phase liquid chromatography coupledto mass spectrometry. Many researches have been carried out to study the effects on identification per-formances of chromatographic parameters such as the stationary phase and column dimensions, mobilephase composition and flow rate, as well as the gradient slope and length. However, little attention isusually paid to the injection solvent composition.In this study, we investigated the effect of the injection solvent on protein identification parameters(number of distinct peptides, amino acid coverage and MS/MS search score) as well as sensitivity. Trypticpeptides from six different proteins, covering a wide range of physicochemical properties, were employedas training set. Design of experiments was employed as a tool to highlight the factors related to thecomposition of the injection solvent that significantly influenced the obtained results. Optimal resultsfor the training set were applied to analysis of more complex samples. The experiments pointed outoptimising the composition of the injection solvent had a strong beneficial effect on all the consideredresponses. On the basis of these results, an approach to determine optimal conditions was proposed tomaximise the protein identification performances and detection sensitivity. [less ▲]

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See detailLes conséquences de la philosophie
Longo, Giuseppe; Cavazzini, Andrea ULg

in Glass Bead (2016)

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See detailImpact of feeding and housing on the development ofosteochondrosis in foals—A longitudinal study
Mendoza García, Luis ULg; Lejeune, Jean-Philippe ULg; Caudron, Isabelle ULg et al

in Preventive Veterinary Medicine (2016), 127

Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of ... [more ▼]

Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of osteochondral fragments in the articulation, fissures or subchondral bone cysts in the growth cartilage. Occurrence of osteochondrosis is influenced by a complex interaction of different factors. Among these, the effect of the housing and the feeding of the foals during their first months of life, have been described as risk factors for the development of osteochondrosis. The aim of this study was to investigate the evolution of OCD lesions with a longitudinal study in 204 young foals from 6 to 18 months in comparison to the type of feeding and the type of housing conditions. These factors and OCD status were obtained by a questionnaire and radiological examination, respectively. This allowed dividing the foals into four groups according to the initial OCD status and the evolution of the condition. As a result, we found that foals fed with concentrates show a higher probability to develop OCD lesions (p = 0.06), while foals not receiving concentrates, had a higher probability to heal from existing OCD lesions (p = 0.001). This study supports the theory that management factors such as feeding or housing may influence the evolution of the osteochondrosis disease. [less ▲]

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See detailÂgisme et surestimation des difficultés cognitives des personnes âgées: une revue de la question
Marquet, Manon ULg; Missotten, Pierre ULg; Adam, Stéphane ULg

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2016), 14(2), 177-186

Stigmatization related to age (i.e., ageism) is a widespread phenomenon in the modern industrial societies where older people are perceived as cognitively incompetent. Therefore negative stereotypes about ... [more ▼]

Stigmatization related to age (i.e., ageism) is a widespread phenomenon in the modern industrial societies where older people are perceived as cognitively incompetent. Therefore negative stereotypes about age-related cognitive decline may have a detrimental influence on older adults on their cognitive performance. The aim of the present review is to understand how stereotypes can influence the performance of the elderly on cognitive tests. We first describe the stereotype threat phenomenon by providing an overview of situations likely to produce stereotype threat, as well as contextual and personal characteristics that moderate its effects. Possible mechanisms underlying these influences on cognitive performance are also presented. Secondly, we address self-stereotyping, which explains long-term negative effects of stereotypes and their unconscious influence on older adults’ cognitive performance. However, some age stereotypes have also positive effects on aged people, as shown by some studies describing such beneficial effects of positive stereotypes on cognitive performance. Finally we try to understand why negative age stereotyping has a much stronger influence on important behavioral outcomes among older adults than does positive age stereotyping. Given all these results, we examine how negative age stereotypes may impact older adults’ cognitive performance in real-world settings such as during a cognitive assessment. [less ▲]

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See detailBovine Staphylococcus aureus: Subtyping, evolution, and zoonotic transfer.
Boss, R.; Cosandey, A.; Luini, M. et al

in Journal of dairy science (2016), 99(1), 515-28

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that ... [more ▼]

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that Staph. aureus isolated from bovine intramammary infections are genetically heterogeneous, with Staph. aureus genotype B (GTB) and GTC being the most prominent genotypes. Furthermore, Staph. aureus GTB was found to be contagious, whereas Staph. aureus GTC and all the remaining genotypes were involved in individual cow disease. In addition to RS-PCR, other methods for subtyping Staph. aureus are known, including spa typing and multilocus sequence typing (MLST). They are based on sequencing the spa and various housekeeping genes, respectively. The aim of the present study was to compare the 3 analytic methods using 456 strains of Staph. aureus isolated from milk of bovine intramammary infections and bulk tanks obtained from 12 European countries. Furthermore, the phylogeny of animal Staph. aureus was inferred and the zoonotic transfer of Staph. aureus between cattle and humans was studied. The analyzed strains could be grouped into 6 genotypic clusters, with CLB, CLC, and CLR being the most prominent ones. Comparing the 3 subtyping methods, RS-PCR showed the highest resolution, followed by spa typing and MLST. We found associations among the methods but in many cases they were unsatisfactory except for CLB and CLC. Cluster CLB was positive for clonal complex (CC)8 in 99% of the cases and typically positive for t2953; it is the cattle-adapted form of CC8. Cluster CLC was always positive for tbl 2645 and typically positive for CC705. For CLR and the remaining subtypes, links among the 3 methods were generally poor. Bovine Staph. aureus is highly clonal and a few clones predominate. Animal Staph. aureus always evolve from human strains, such that every human strain may be the ancestor of a novel animal-adapted strain. The zoonotic transfer of IMI- and milk-associated strains of Staph. aureus between cattle and humans seems to be very limited and different hosts are not considered as a source for mutual, spontaneous infections. Spillover events, however, may happen. [less ▲]

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See detailStructural analysis of ruthenium–arene complexes using ion mobility mass spectrometry, collision-induced dissociation, and DFT
Cserwinska, Izabella; Far, Johann ULg; Kune, Christopher ULg et al

in Dalton Transactions (2016), 45

Ion mobility mass spectrometry (IM-MS) and collision-induced dissociation (CID) techniques were used to investigate the influence of the phosphine ligand on the physicochemical properties of [RuCl2(p ... [more ▼]

Ion mobility mass spectrometry (IM-MS) and collision-induced dissociation (CID) techniques were used to investigate the influence of the phosphine ligand on the physicochemical properties of [RuCl2(p-cymene)(PCy3)] (1), [RuCl2(p-cymene)-(PPh3)] (2), and [RuCl2(p-cymene)(PTA)] (3) in the gas phase (PTA is 1,3,5-triaza-7-phosphaadamantane). Electrospray ionization of complexes 1 and 2 led to the corresponding [RuCl(p-cymene)(PR3)]+ ions via the dissociation of a chlorido ligand, whereas RAPTA-C (3) afforded two molecular ions by in-source oxidation ([RuIIICl2(p-cymene)(PTA)]+) or protonation ([RuCl2(p-cymene)(PTA+H)]+). Control experiments showed that the balance between these two ionization paths was strongly influenced by the nature of the solvent used for infusion. Collision cross sections (CCSs) of the four molecular ions accurately reflected the variations of steric bulk inferred from the Tolman steric parameters (θ) of the phosphine ligands. Moreover, DFT calculations combined with a model based on the kinetic theory of gases (the trajectory method of the IMoS software) afforded reliable CCS predictions. The almost two times higher dipole moment of [RuCl2(p-cymene)-(PTA+H)]+ (μ = 13.75 D) compared to [RuIIICl2(p-cymene)(PTA)]+ (μ = 7.18 D) was held responsible for increased ion-induced dipole interactions with a polarizable drift gas such as N2. Further experiments with He and CO2 confirmed that increasing the polarizability of the buffer gas improved the separation between the two molecular ions derived from complex 3. The fragmentation patterns of complexes 1–3 were determined by CID. The sequence of collision voltages at which 50% of a precursor ion dissociates (V50) recorded for the molecular ions derived from compounds 1–3 was in good agreement with simple electronic considerations based on the donor strength of the phosphine ligand. Thus, the CCS and V50 parameters used to determine the shape and stability of ionic species in the gas phase are complementary to the Tolman steric and electronic parameters (θ and TEP) commonly used by organometallic chemists in condensed phases. [less ▲]

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See detailĐánh giá tiềm năng sử dụng phụ phẩm ngành rượu cồn để sản xuất thức ăn chăn nuôi tại Việt Nam
Tu Viet, Phu; Pham Kim, Dang; Nguyen Cong, Oanh ULg et al

in Journal of Science and Development (2016), 14(1), 36-45

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high ... [more ▼]

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high feed price due to the dependence on imported raw materials (estimated at 65-70%). The total value of imported raw materials for animal feed production in 2013 was estimated at $ 4.1 billion. Worldwide, by-products from alcohol industry has been studied and processed into main raw materials (DDG and DDGS) for animal feed production. Meanwhile in our country, these by-products are used in its raw form in livestock feeding or used for other purposes with low economic benefit. The objective of this study was to evaluate the potential uses of the by-products from alcohol industry to produce animal feed and increase the added value for these products. The main methods used in this study were Value Chain Analysis (VCA) and SWOT analysis. Results of the study showed the different value chains of the alcohol industry as well as opportunities for the use of by-products for the production of animal feed. The results also indicate the difficulties and challenges of these application. [less ▲]

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See detailGenome Sequences of Four Strains of Mycobacterium avium subsp. hominissuis, Isolated from Swine and Humans, Differing in Virulence in a Murine Intranasal Infection Model
Bruffaerts; Vluggen, C; Duytschaever, L et al

in Genome Announcements (2016), 4(3),

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See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (deuxième partie)
Léonard, Laura ULg; Caprasse, Olivier; Dieux, Xavier et al

in Revue Critique de Jurisprudence Belge [= RCJB] (2016), (2),

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See detailIdentification of nonlinear normal modes of engineering structures under broadband forcing
Noël, Jean-Philippe ULg; Renson, Ludovic ULg; Grappasonni, Chiara ULg et al

in Mechanical Systems & Signal Processing (2016)

The objective of the present paper is to develop a two-step methodology integrating system identification and numerical continuation for the experimental extraction of nonlinear normal modes (NNMs) under ... [more ▼]

The objective of the present paper is to develop a two-step methodology integrating system identification and numerical continuation for the experimental extraction of nonlinear normal modes (NNMs) under broadband forcing. The first step processes acquired input and output data to derive an experimental state-space model of the structure. The second step converts this state-space model into a model in modal space from which NNMs are computed using shooting and pseudo-arclength continuation. The method is demonstrated using noisy synthetic data simulated on a cantilever beam with a hardening-softening nonlinearity at its free end. [less ▲]

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See detailFlow cytometry community fingerprinting and amplicon sequencing for the assessment of landfill leachate cellulolytic bioaugmentation
Kinet, Romain ULg; Dzaomuho, Phidias; Baert, Jonathan ULg et al

in Bioresource Technology (2016)

Flow cytometry (FCM) is a high throughput single cell technology that is actually becoming widely used for studying phenotypic and genotypic diversity among microbial communities. This technology is ... [more ▼]

Flow cytometry (FCM) is a high throughput single cell technology that is actually becoming widely used for studying phenotypic and genotypic diversity among microbial communities. This technology is considered in this work for the assessment of a bioaugmentation treatment in order to enhance cellulolytic potential of landfill leachate. The experimental results reveal the relevant increase of leachate cellulolytic potential due to bioaugmentation. Cytometric monitoring of microbial dynamics along these assays is then realized. The Flow FP package is used to establish microbial samples fingerprint from initial 2D cytometry histograms. This procedure allows highlighting microbial communities' variation along the assays. Cytometric and 16S rRNA gene sequencing fingerprinting methods are then compared. The two approaches give same evidence about microbial dynamics throughout digestion assay. There are however a lack of significant correlation between cytometric and amplicon sequencing fingerprint at genus or species level. Same phenotypical profiles of microbiota during assays matched to several 16S rRNA gene sequencing ones. Flow cytometry fingerprinting can thus be considered as a promising routine on-site method suitable for the detection of stability/variation/disturbance of complex microbial communities involved in bioprocesses. [less ▲]

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See detailPyoverdine and histicorrugatin-mediated iron acquisition in Pseudomonas thivervalensis
Matthijs, Sandra; Brandt, Nathalie; Ongena, Marc ULg et al

in Biometals (2016), 29(3), 467-485

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See detailTreacher Collins syndrome: a clinical and molecular study based on a large series of patients.
Vincent, Marie; Genevieve, David; Ostertag, Agnes et al

in Genetics in medicine : official journal of the American College of Medical Genetics (2016), 18(1), 49-56

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically ... [more ▼]

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically characterized by bilateral mandibular and malar hypoplasia, downward-slanting palpebral fissures, and microtia. To date, three genes have been identified in TCS:,TCOF1, POLR1D, and POLR1C. METHODS: We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS. Phenotype-genotype correlations were investigated for 19 clinical features, between TCOF1 and POLR1D, and the type of mutation or its localization in the TCOF1 gene. RESULTS: We identified 92/146 patients (63%) with a molecular anomaly within TCOF1, 9/146 (6%) within POLR1D, and none within POLR1C. Among the atypical negative patients (with intellectual disability and/or microcephaly), we identified four patients carrying a mutation in EFTUD2 and two patients with 5q32 deletion encompassing TCOF1 and CAMK2A in particular. Congenital cardiac defects occurred more frequently among patients with TCOF1 mutation (7/92, 8%) than reported in the literature. CONCLUSION: Even though TCOF1 and POLR1D were associated with extreme clinical variability, we found no phenotype-genotype correlation. In cases with a typical phenotype of TCS, 6/146 (4%) remained with an unidentified molecular defect.Genet Med 18 1, 49-56. [less ▲]

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See detailPersistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease.
Gonzalez Aguilera, B.; Syrios, P.; Gadisseur, R et al

in Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2016)

Phantom hCG refers to persistent mild elevations of hCG, leading physicians to unnecessary treatments whereas neither a true hCG nor a trophoblastic disease is present. We report the case of a 23-year-old ... [more ▼]

Phantom hCG refers to persistent mild elevations of hCG, leading physicians to unnecessary treatments whereas neither a true hCG nor a trophoblastic disease is present. We report the case of a 23-year-old woman with persistent low levels of serum hCG detected one month after miscarriage. As choriocarcinoma was suspected, a chemotherapy trial of methotrexate was prescribed, without any hCG reduction. Subsequently, laparoscopy ruled out a trophoblastic residue and the patient was referred to the Endocrine Unit for further investigations. While low levels of hCG were still detected in serum, no hCG was detected in the urine. In addition, when serum was processed in a HBT tube for revealing heterophilic antibodies, hCG was no longer detected. Such finding indicated the presence of phantom hCG due to heterophilic mouse antibodies interaction. This case raises the need of clinico-biological discussion to avoid inappropriate therapeutic decisions. Based on this case experience and after review of the literature, we suggest that current gynecological protocols for the diagnosis and treatment of trophoblastic disease should consider the inclusion of urinary hCG and/or a test for serum heterophilic antibodies when appropriate. [less ▲]

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See detailComment j'explore le malaise du nourrisson
Zambelli, Laura ULg; Battisti, Oreste ULg

in Revue Médicale de Liège (2016), 71

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See detailPolyphasic characterization of 10 selected ecologically relevant filamentous cyanobacterial strains from the South Shetland Islands, Maritime Antarctica
Jancusova, Miroslava; Kovacik, Lubomir; Pereira, Antonio Batista et al

in FEMS Microbiology Ecology (2016), 92(7), 100

The evolutionary relationships of 10 Antarctic cyanobacterial strains of the order Oscillatoriales isolated from King George and Deception Islands, South Shetland Islands were studied by a polyphasic ... [more ▼]

The evolutionary relationships of 10 Antarctic cyanobacterial strains of the order Oscillatoriales isolated from King George and Deception Islands, South Shetland Islands were studied by a polyphasic approach (morphology, 16S rRNA and internal transcribed spacer sequences). The studied taxa are characteristic of coastal Antarctic biotopes, where they form distinct populations and ecologically delimited communities. They were isolated from terrestrial habitats: microbial mats in seepages; crusts on soil, rocks, bones and mosses; mud, sometimes close to bird colonies; and from guano. Based on major phenotypic features, the strains were divided into four distinct morphotypes: Leptolyngbya borchgrevinkii (A), Leptolyngbya frigida (B), Microcoleus sp. (C) and Wilmottia murrayi (D). This morphological identification was in agreement with the phylogenetic relationships. For the first time, the 16S rRNA gene sequence of a strain corresponding to the L. borchgrevinkii morphotype was determined. Morphotype B is most related to sequences assigned to L. frigida isolated from microbial mats of coastal lakes in East Antarctica. Morphotype C belongs to a cluster including strains with morphotypes corresponding to Microcoleus attenuatus, Microcoleus favosus and Microcoleus sp., which are from Antarctica and other continents. Morphotype D is grouped with sequences assigned to W. murrayi mostly isolated from Antarctica. [less ▲]

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See detailAn age-calibrated definition of chronic kidney disease: Rationale and benefits.
DELANAYE, Pierre ULg; Glassock, Richard; Pottel, H et al

in Clinical Biochemist. Reviews (2016), 37(1),

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See detailSmall-Angle Scattering Analysis of Empty or Loaded Hierarchical Porous Materials
Gommes, Cédric ULg; Prieto, Gonzalo; de Jongh, Petra

in Journal of Physical Chemistry C (2016), 120(3), 14881506

Small-angle scattering of x-rays (SAXS) or neutrons (SANS) is one of the few experimental methods that can in principle be used for the in situ study at the mesoscopic scale of physicochemical phenomena ... [more ▼]

Small-angle scattering of x-rays (SAXS) or neutrons (SANS) is one of the few experimental methods that can in principle be used for the in situ study at the mesoscopic scale of physicochemical phenomena occurring inside nanoporous solids. However, the potential of the method is often limited by the lack of suitable data analysis methods to convert scattering data into real-space structural information. This is notably the case for most porous materials of practical interest, which exhibit a hierarchical structure with micro, meso, and macropores, with often a secondary material confined in the pores, such as in supported catalysts, as well as fuel-cell and battery materials. In the present contribution, we propose a general analysis of x-ray scattering by this type of material. Assuming that each structural level is statistically independent from the others and has a distinct characteristic length scale, compact mathematical expressions are derived for the scattering of the entire hierarchical structure. The results are particularised to the SAXS analysis of SBA-15 ordered mesoporous silica loaded with copper nitrate as well as to supported catalysts obtained after heat treatment of that material. The SAXS data analysis shows that the nitrate fills both the micro and mesopores of the material, while the metallic copper obtained after heat treatment is found only in the mesopores. Moreover, the mesoscopic-scale spatial distribution of the metal depends on the heat treatment, in line with earlier electron tomography studies. The main ideas underlying the SAXS data analysis were presented in an recent Communication [Gommes et al., Angew. Chem. Intl. Ed. 54 (2015) 11804-11808]. Here we generalise the approach and we provide a comprehensive discussion of how any level in a hierarchical structure contributes to its overall scattering pattern. The results, as well as the general modelling methodology, will be of interest to anyone interested in the quantitative analysis of small-angle scattering data of empty or loaded porous solids, and more generally of any type of hierarchical material. [less ▲]

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See detailCombining microCT-based characterization with empirical modelling as a robust screening approach for the design of optimized CaP-containing scaffolds for progenitor cell-mediated bone formation.
Kerckhofs, G.; Chai, Y. C.; Luyten, F. P. et al

in Acta Biomaterialia (2016), 35

Biomaterials are a key ingredient to the success of bone tissue engineering (TE), which focuses on the healing of bone defects by combining scaffolds with cells and/or growth factors. Due to the widely ... [more ▼]

Biomaterials are a key ingredient to the success of bone tissue engineering (TE), which focuses on the healing of bone defects by combining scaffolds with cells and/or growth factors. Due to the widely variable material characteristics and patient-specificities, however, current bone TE strategies still suffer from low repeatability and lack of robustness, which hamper clinical translation. Hence, optimal TE construct (i.e. cells and scaffold) characteristics are still under debate. This study aimed to reduce the material-specific variability for cell-based construct design, avoiding trial-and-error, by combining microCT characterization and empirical modelling as an innovative and robust screening approach. Via microCT characterization we have built a quantitative construct library of morphological and compositional properties of six CE approved CaP-based scaffolds (CopiOs(R), BioOss, Integra Mozaik, chronOS Vivify, MBCP and ReproBone), and of their bone forming capacity and in vivo scaffold degradation when combined with human periosteal derived cells (hPDCs). The empirical model, based on the construct library, allowed identification of the construct characteristics driving optimized bone formation, i.e. (a) the percentage of beta-TCP and dibasic calcium phosphate, (b) the concavity of the CaP structure, (c) the average CaP structure thickness and (d) the seeded cell amount (taking into account the seeding efficiency). Additionally, the model allowed to quantitatively predict the bone forming response of different hPDC-CaP scaffold combinations, thus providing input for a more robust design of optimized constructs and avoiding trial-and error. This could improve and facilitate clinical translation. STATEMENT OF SIGNIFICANCE: Biomaterials that support regenerative processes are a key ingredient for successful bone tissue engineering (TE). However, the optimal scaffold structure is still under debate. In this study, we have provided a useful innovative approach for robust screening of potential biomaterials or constructs (i.e. scaffolds seeded with cells and/or growth factors) by combining microCT characterization with empirical modelling. This novel approach leads to a better insight in the scaffold parameters influencing progenitor cell-mediated bone formation. Additionally, it serves as input for more controlled and robust design of optimized CaP-containing bone TE scaffolds. Hence, this novel approach could improve and facilitate clinical translation. [less ▲]

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See detailA molecular approach for the rapid, selective and sensitive detection of Exophiala jeanselmei in environmental samples: development and performance assessment of a real-time PCR assay.
Libert, X.; Chasseur, C.; Packeu, A. et al

in Applied Microbiology and Biotechnology (2016), 100(3), 1377-1392

Exophiala jeanselmei is an opportunistic pathogenic black yeast growing in humid environments such as water reservoirs of air-conditioning systems. Because this fungal contaminant could be vaporized into ... [more ▼]

Exophiala jeanselmei is an opportunistic pathogenic black yeast growing in humid environments such as water reservoirs of air-conditioning systems. Because this fungal contaminant could be vaporized into the air and subsequently cause health problems, its monitoring is recommended. Currently, this monitoring is based on culture and microscopic identification which are complex, sometimes ambiguous and time-demanding, i.e., up to 21 days. Therefore, molecular, culture-independent methods could be more advantageous for the monitoring of E. jeanselmei. In this study, we developed a SYBR(R)green real-time PCR assay based on the internal transcribed spacer 2 from the 18S ribosomal DNA complex for the specific detection of E. jeanselmei. The selectivity (100 %), PCR efficiency (95.5 %), dynamic range and repeatability of this qPCR assay were subsequently evaluated. The limit of detection for this qPCR assay was determined to be 1 copy of genomic DNA of E. jeanselmei. Finally, water samples collected from cooling reservoirs were analyzed using this qPCR assay to deliver a proof of concept for the molecular detection of E. jeanselmei in environmental samples. The results obtained by molecular analysis were compared with those of classical methods (i.e., culture and microscopic identification) used in routine analysis and were 100 % matching. This comparison demonstrated that this SYBR(R)green qPCR assay can be used as a molecular alternative for monitoring and routine investigation of samples contaminated by E. jeanselmei, while eliminating the need for culturing and thereby considerably decreasing the required analysis time to 2 days. [less ▲]

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See detailLa empresa social en Bélgica: diversidad de fuentes, modelos y campos
Huybrechts, Benjamin ULg

in Revista de la Academia (2016), 21

Este artículo está estructurado como sigue: la primera sección introductoria revisa las principales raíces históricas que han conduci- do a la emergencia de una diversidad de modelos relacionados con la ... [more ▼]

Este artículo está estructurado como sigue: la primera sección introductoria revisa las principales raíces históricas que han conduci- do a la emergencia de una diversidad de modelos relacionados con la empresa social y a la economía social en Bélgica. Enseguida, la segunda sección esboza los principales aspectos de esos modelos en relación a sus formas legales, tipos de misión social a las que se orientan, dinámicas de gobierno y recursos. En la tercera sección, esos modelos son ilustrados in diferentes campos de actividad, tanto establecidos como emergentes. Finalmente, la cuarta sección propone un análisis transversal de los principales tendencias y desafíos que enfrenta el desarrollo y coexisten- cia de los diferentes modelos. [less ▲]

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See detailLe syndrome thyro-gastrique auto-immun : actualités cliniques et thérapeutiques
VALDES SOCIN, Hernan Gonzalo ULg; SID, Sélim ULg; LUTTERI, Laurence ULg et al

in Vaisseaux, Coeur, Poumons (2016), 21(4), 11-15

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See detailAdding mucins to an in vitro batch fermentation model of the large intestine induces changes in microbial population isolated from porcine feces depending on the substrate
Tran, Thi Hanh Tham ULg; Boudry, Christelle ULg; Everaert, Nadia ULg et al

in FEMS Microbiology Ecology (2016), 92(2), 13

Adding mucus to in vitro fermentation models of the large intestine showed that some genera, namely lactobacilli, are dependent on host-microbiota interactions and that they rely on mucosa layers to ... [more ▼]

Adding mucus to in vitro fermentation models of the large intestine showed that some genera, namely lactobacilli, are dependent on host-microbiota interactions and that they rely on mucosa layers to increase their activity. This study investigates whether this dependence on mucus is substrate-dependent and to which extend other genera are impacted by the presence of mucus. Inulin and cellulose were fermented in vitro by a fecal inoculum from pig in the presence or not of mucin-beads in order to compare fermentation patterns and bacterial communities. Mucins increased final gas production with inulin and shifted short-chain fatty acids molar ratios (P<0.001). QPCR analyses revealed that Lactobacillus spp. and Bifidobacterium spp. decreased with mucins, but Bacteroides spp. increased when inulin was fermented. A more in-depth community analysis indicated that the mucins increased Proteobacteria (0.55 vs. 0.25 %, P=0.013), Verrucomicrobia (5.25 vs. 0.03 %, P=0.032), Ruminococcaceae, Bacteroidaceae, and Akkermansia spp.. Proteobacteria (5.67 vs. 0.55 %, P<0.001) and Lachnospiraceae (33 vs. 10.4 %) were promoted in the mucuscompared to the broth, while Ruminococcaceae decreased. The introduction of mucins affected many microbial genera and fermentation patterns, but from PCA results, the impact of mucus was independent from the fermentation substrate. [less ▲]

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See detailLes droits fondamentaux, au coeur de la pluralité des sources et de la pluralité des juges: vers une "dématérialisation" des droits fondamentaux?
Rosoux, Géraldine ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016)

L'article contient un résumé de la thèse de doctorat de l'auteur, publiée chez Bruylant en 2015.

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See detailInvolvement of Executive Functions in Children’s Metamemory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2016), 30(1), 70-80

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were ... [more ▼]

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were assessed based on the performance of a group of 100 children (aged 4, 6, 9 and 11 years) on a battery of executive tasks. At the same time, the influence of variables such as intelligence, vocabulary and parental education level was also investigated. Results of mediation analyses reveal that the relation between children’s age and internal strategy knowledge was partially mediated by working memory skills but that executive functions did not mediate the impact of chronological age on children’s knowledge of external strategies or of memory functioning. Additionally, verbal fluency predicted internal and external strategy knowledge. Implications for general learning theories in childhood are discussed [less ▲]

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See detailAn investigation of structural dimension variation in electrostatically-coupled MEMS resonator pairs using mode-localization
Wood, Graham; Chun, Zhao; Pu, Suan et al

in IEEE Sensors Journal (2016)

If a pair of MEMS resonators are electrostatically coupled together, the vibration amplitude ratios at the resonant frequencies of the resulting coupled system are sensitive to stiffness perturbation. An ... [more ▼]

If a pair of MEMS resonators are electrostatically coupled together, the vibration amplitude ratios at the resonant frequencies of the resulting coupled system are sensitive to stiffness perturbation. An imbalance between the two resonators causes the confinement of vibration energy when the system is resonating, an effect known as mode-localization. The degree of localization can be determined by extracting the amplitude ratio of the resonators through capacitive transduction. In this paper, we have fabricated MEMS devices, using a dicing-free silicon-on-insulator process, consisting of pairs of closely spaced microresonators. Each resonator consists of a clamped-clamped beam with a wider section in the middle, which is the location of the electrostatic coupling, instituted through the DC biasing of the resonators. Several devices have been fabricated, with the length of the anchor beams being varied, which influences the frequency of resonance. Stiffness imbalance between the resonators has been introduced through electrostatic spring softening, with the sensitivity of the amplitude ratio of the resonant mode shape being greater for the higher frequency, shorter anchor devices. The sensitivities of the devices in this study have been found to be 9 times greater than state-of-the-art two-degree-of-freedom mode-localized sensors. [less ▲]

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See detailLes Alarmes de Mars de Jean d'Auton. Édition et commentaire
Dumont, Jonathan ULg

in Annuaire - Bulletin de la Société de l'Histoire de France (2016), 551

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See detailGlucose Control in the ICU: A Continuing Story.
Preiser, Jean-Charles; Chase, J. Geoffrey; Hovorka, Roman et al

in Journal of diabetes science and technology (2016)

In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing ... [more ▼]

In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing authorities and to enable comparisons across studies and devices. Adequately powered, good quality, randomized, controlled studies are needed to assess the impact of different CGM devices on the quality of glucose control, workload, and costs. The additional effects of continuing glucose control on the general floor after the ICU stay also need to be investigated. Current algorithms need to be adapted and validated for CGM, including effects on glucose variability and workload. Improved collaboration within the industry needs to be encouraged because no single company produces all the necessary components for an automated closed-loop system. Combining glucose measurement with measurement of other variables in 1 sensor may help make this approach more financially viable. [less ▲]

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See detailFDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy.
LOVINFOSSE, Pierre ULg; Janvary, Zsolt Levente; COUCKE, Philippe ULg et al

in European journal of nuclear medicine and molecular imaging (2016)

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume ... [more ▼]

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume or heterogeneity could predict the outcome in patients with non-small cell lung cancers (NSCLC) treated by stereotactic body radiation therapy (SBRT). METHODS: Sixty-three patients with NSCLC treated by SBRT underwent a 18F-FDG PET/CT before treatment. Maximum and mean standard uptake value (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), as well as 13 global, local and regional textural features were analysed. The predictive value of these parameters, along with clinical features, was assessed using univariate and multivariate analysis for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Cutoff values were obtained using logistic regression analysis, and survivals were compared using Kaplan-Meier analysis. RESULTS: The median follow-up period was 27.1 months for the entire cohort and 32.1 months for the surviving patients. At the end of the study, 25 patients had local and/or distant recurrence including 12 who died because of the cancer progression. None of the clinical variables was predictive of the outcome, except age, which was associated with DFS (HR 1.1, P = 0.002). None of the 18F-FDG PET/CT or clinical parameters, except gender, were associated with OS. The univariate analysis showed that only dissimilarity (D) was associated with DSS (HR = 0.822, P = 0.037), and that several metabolic measurements were associated with DFS. In multivariate analysis, only dissimilarity was significantly associated with DSS (HR = 0.822, P = 0.037) and with DFS (HR = 0.834, P < 0.01). CONCLUSION: The textural feature dissimilarity measured on the baseline 18F-FDG PET/CT appears to be a strong independent predictor of the outcome in patients with NSCLC treated by SBRT. This may help selecting patients who may benefit from closer monitoring and therapeutic optimization. [less ▲]

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See detailPoplar-root-knot nematode interaction: a model for perennial woody species
Baldacci-Cresp, Fabien; Sacre, Pierre-Yves ULg; Twyffels, Laure et al

in Molecular Plant-Microbe Interactions [=MPMI] (2016), 29(7), 560-572

Plant root-knot nematode interaction studies are performed on several host plant models. However, even though root-knot nematodes interact with trees, no perennial woody model has been explored so far. We ... [more ▼]

Plant root-knot nematode interaction studies are performed on several host plant models. However, even though root-knot nematodes interact with trees, no perennial woody model has been explored so far. We show here that poplar (Populus tremula x Populus alba) grown in vitro is susceptible to Meloidogyne incognita as this nematode is able to penetrate, to induce feeding sites and to reproduce in poplar roots. As analyzed by Raman spectromicroscopy, the cell walls of the giant cells, with typical characteristics of transfer cell walls, were not lignified and were composed mainly of pectin and cellulose. To better depict the poplar-nematode interaction at the molecular level, a quantitative RT-PCR analysis was performed to study changes in poplar gene expression in galls compared to non-infected roots. Three marker genes, reported for other plant hosts, including expansin A, histone 3.1 and asparagine synthase, were conserved for poplar-nematode interaction. In addition, the down-regulation of four genes coding for enzymes of the lignin biosynthesis pathway was evidenced in galls, suggesting a modification in lignin composition within galls developed in poplar roots. Together, this study shows that poplar is a suitable model host for specific traits of tree-nematode interaction. [less ▲]

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See detailBetween Street Vendors, Singing Slaves, and Envy
Vanesse, Sylvain ULg

in Chronika (2016), 6

When the well-known “House of the Ephebe” was excavated in Pompeii, a statuary group composed of four bronze figurines was found. Those small statues are now known as “Placentarii”, namely “pastry cooks.” ... [more ▼]

When the well-known “House of the Ephebe” was excavated in Pompeii, a statuary group composed of four bronze figurines was found. Those small statues are now known as “Placentarii”, namely “pastry cooks.” They were given this name because they were thought selling their products placed on a plate, shouting to attract the clients. This interpretation explains the particular hand gesture of those men, touching their throat. This theory seems very conceivable and is generally accepted by a large scientific majority. However, some iconographic elements don’t fit with this hypothesis. Indeed, how do we explain the nakedness of those four men, their thinness, their weird facial features and their disproportionate phalluses? Other figurines – terracotta, bronzes, amulets, mosaics – depicted with the same specific features were found among the archaeological material from the Mediterranean basin. There is –nearly– no question that those objects are representations of the Envy personified, also known as Phthonos, or of an envious person (phthoneros). Would it be possible to see in those four bronzes not –only– pastry cooks, but an embodiment of Envy, filled with apotropaic value? A fresh perspective –literary and archaeological– will help and issue a clarification about this new theory. [less ▲]

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See detailCapitalizing in fine milk composition for breeding and management of dairy cows
Gengler, Nicolas ULg; Soyeurt, Hélène ULg; Dehareng, Fréderic et al

in Journal of Dairy Science (2016), 99

The challenge of managing and breeding dairy cows is permanently adapting to changing production circumstances under socio-economic constraints. If managing and breeding address different timeframes of ... [more ▼]

The challenge of managing and breeding dairy cows is permanently adapting to changing production circumstances under socio-economic constraints. If managing and breeding address different timeframes of action, both need relevant phenotypes that allow for precise monitoring of the status of the cows, and their health, behavior, and well-being as well as their environmental impact and the quality of their products (i.e., milk and subsequently dairy products). Milk composition has been identified as an important source of information because it could reflect, at least partially, all these elements. Major conventional milk components such as fat, protein, urea, and lactose contents are routinely predicted by mid-infrared (MIR) spectrometry and have been widely used for these purposes. But, milk composition is much more complex and other nonconventional milk components, potentially predicted by MIR, might be informative. Such new milk-based phenotypes should be considered given that they are cheap, rapidly obtained, usable on a large scale, robust, and reliable. In a first approach, new phenotypes can be predicted from MIR spectra using techniques based on classical prediction equations. This method was used successfully for many novel traits (e.g., fatty acids, lactoferrin, minerals, milk technological properties, citrate) that can be then useful for management and breeding purposes. An innovation was to consider the longitudinal nature of the relationship between the trait of interest and the MIR spectra (e.g., to predict methane from MIR). By avoiding intermediate steps, prediction errors can be minimized when traits of interest (e.g., methane, energy balance, ketosis) are predicted directly from MIR spectra. In a second approach, research is ongoing to detect and exploit patterns in an innovative manner, by comparing observed with expected MIR spectra directly (e.g., pregnancy). All of these traits can then be used to define best practices, adjust feeding and health management, improve animal welfare, improve milk quality, and mitigate environmental impact. Under the condition that MIR data are available on a large scale, phenotypes for these traits will allow genetic and genomic evaluations. Introduction of novel traits into the breeding objectives will need additional research to clarify socio-economic weights and genetic correlations with other traits of interest. [less ▲]

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See detailVirtual Issue celebrating the 100th volume of the Journal of Animal Physiology and Animal Nutrition
Fascetti, A. J.; Everaert, Nadia ULg

in Journal of Animal Physiology and Animal Nutrition (2016), 100(1), 1-2

[No abstract available]

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See detailDSIMA: A testbed for the quantitative analysis of interaction models within distribution networks
Mathieu, Sébastien ULg; Louveaux, Quentin ULg; Ernst, Damien ULg et al

in Sustainable Energy, Grids and Networks (2016), 5

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in ... [more ▼]

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in which the distribution system operator, the transmission system operator, producers and retailers make their decisions based on mixed-integer linear programs. This testbed helps to highlight the characteristics of an interaction model, the benefits for the agents and eases the detection of unwanted or abusive behaviors which decreases the welfare. The testbed is implemented in Python and the optimization problems are encoded in the modeling language ZIMPL. A web interface is coupled with an instance generator using macroscopic parameters of the system such as the total power production. This testbed is, therefore, well suited to test the implemented interaction models on various scenarios and to extend the implementation to other models. Five interaction models developed with industrial partners are simulated over a year on a 75-bus test system. Simulations show that interaction models relying on active network management, as they have been developed, lead to substantial welfare even though they suffer from a lack of coordination between the DSO and the TSO. A conservative interaction model restricting grid users to an access range that is computed ahead of time to prevent any congestion, avoids shedding distributed generation but considerably restrains the amount of distributed production. [less ▲]

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See detailNetworks of prospective thoughts: the organisational role of emotion and its impact on well-being
Demblon, Julie ULg; D'Argembeau, Arnaud ULg

in Cognition & Emotion (2016), 30

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully ... [more ▼]

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully understood. Here, we investigated the organisational role of emotion by using cues of different valence for eliciting event networks. We found that manipulating the emotional valence of cues influenced the characteristics of events within networks, and that members of a network were more similar to each other on affective components than they were to members of other networks. Furthermore, a substantial proportion of events within networks were part of thematic clusters and cluster membership significantly modulated the impact of represented events on current well-being, in part through an intensification of the emotion felt when thinking about these events. These findings demonstrate that emotion contributes to the organisation of future thoughts in networks that can affect people’s well-being. [less ▲]

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See detailAggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome.
Naves, Luciana A.; Daly, Adrian Francis ULg; Dias, Luiz Augusto et al

in Endocrine (2016)

X-linked acro-gigantism (X-LAG) syndrome is a newly described disease caused by microduplications on chromosome Xq26.3 leading to copy number gain of GPR101. We describe the clinical progress of a ... [more ▼]

X-linked acro-gigantism (X-LAG) syndrome is a newly described disease caused by microduplications on chromosome Xq26.3 leading to copy number gain of GPR101. We describe the clinical progress of a sporadic male X-LAG syndrome patient with an Xq26.3 microduplication, highlighting the aggressive natural history of pituitary tumor growth in the absence of treatment. The patient first presented elsewhere aged 5 years 8 months with a history of excessive growth for >2 years. His height was 163 cm, his weight was 36 kg, and he had markedly elevated GH and IGF-1. MRI showed a non-invasive sellar mass measuring 32.5 x 23.9 x 29.1 mm. Treatment was declined and the family was lost to follow-up. At the age of 10 years and 7 months, he presented again with headaches, seizures, and visual disturbance. His height had increased to 197 cm. MRI showed an invasive mass measuring 56.2 x 58.1 x 45.0 mm, with compression of optic chiasma, bilateral cavernous sinus invasion, and hydrocephalus. His thyrotrope, corticotrope, and gonadotrope axes were deficient. Surgery, somatostatin analogs, and cabergoline did not control vertical growth and pegvisomant was added, although vertical growth continues (currently 207 cm at 11 years 7 months of age). X-LAG syndrome is a new genomic disorder in which early-onset pituitary tumorigenesis can lead to marked overgrowth and gigantism. This case illustrates the aggressive nature of tumor evolution and the challenging clinical management in X-LAG syndrome. [less ▲]

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See detailDistributions and Sea-to-air Fluxes of Nitrous Oxide in the South China Sea and the West Philippines Sea
Tseng, Hsiao-Chun; Chen, Chen-Tung Arthur; Borges, Alberto ULg et al

in Deep-Sea Research Part I, Oceanographic Research Papers (2016), 115

Abstract Approximately 600 water samples from the South China Sea (SCS) and 250 water samples from the West Philippines Sea (WPS) were collected during seven cruises from August 2003 to July 2007 to ... [more ▼]

Abstract Approximately 600 water samples from the South China Sea (SCS) and 250 water samples from the West Philippines Sea (WPS) were collected during seven cruises from August 2003 to July 2007 to determine nitrous oxide (N2O) distributions between the surface and a maximum depth of 4250 m. In the SCS, the average surface \{N2O\} concentration exceeded the atmospheric equilibrium concentration (on average 132 ± 23%); however in the WPS, the surface \{N2O\} concentration was lower than the atmospheric equilibrium concentration (on average 90 ± 22%). The \{N2O\} concentration reached a maximum (~23 nmol L−1) in the \{WPS\} at 800–1000 m, and (~28 nmol L−1) at a shallower depth of around 600–800 m in the SCS, owing to vertical mixing and intensive upwelling in the SCS. In the SCS, the surface \{N2O\} concentration was 7.59 ± 1.32 nmol L−1 and the calculated sea-to-air flux was 5.5 ± 3.9 μmol m−2 d−1. The surface \{N2O\} concentration in the WPS, 5.19 ± 1.26 nmol L−1, was lower than that in the SCS. [less ▲]

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See detailThe design of performance monitoring systems in healthcare organizations : a stakeholder perspective
Rouhana, Rima; Van Caillie, Didier ULg

in Journal Medical Libanais = Lebanese Medical Journal (2016), 64/1

Monitoring the hospital’s performance is evolving over time in search of more efficiency by integrating additional levels of care, reducing costs and keeping stuff up-to-date. To fulfill these three ... [more ▼]

Monitoring the hospital’s performance is evolving over time in search of more efficiency by integrating additional levels of care, reducing costs and keeping stuff up-to-date. To fulfill these three potentially divergent aspects and to monitor performance, healthcare administrators are using dissimilar management control tools. To explain why, we suggest to go beyond traditional contingent factors to assess the role of the different stakeholders (governments, patients, authorities, personnel and administrators) that are at the heart of any healthcare organization. So, the main interest of our empirical study is to appraise how healthcare managers can foster strategic “alignment” in chaotic environments. To investigate this subject, we rely first on seminal studies to appraise the role of the main healthcare players and their influence on some organizational attributes (essentially size, lifecycle, structure, climate and technology in use). We then consider the managerial awareness and the perception of a suitable management control system (MCS) to promote a strategy-focused organization. Our methodology is based on a qualitative approach of twenty-two case studies, lead in two heterogeneous environments (Belgium and Lebanon). This method allows to illustrate, for each healthcare player, its positioning within the healthcare systems. Thus, we define how its role, its perception and its responsiveness manipulate the organization’s internal climate and shape the design of the performance monitoring systems. Our findings are expected to add knowledge on the reasons of the choice of adequate management systems, within three different healthcare organizational structures: university, general/university and general hospitals. [less ▲]

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See detailRadio-frequency magnetron sputtering: a versatile tool for CdSe quantum dots depositions with controlled properties
Dahi, Abdellatif; Colson, Pierre ULg; Jamin, Claire et al

in Journal of Material and Environmental Sciences (2016), 7(7), 2277-2287

CdSe nanoparticles are of great interest for many applications. However, their size, shape, and aggregation are still difficult to control by the conventional synthesis methods. Here, we report on the ... [more ▼]

CdSe nanoparticles are of great interest for many applications. However, their size, shape, and aggregation are still difficult to control by the conventional synthesis methods. Here, we report on the synthesis of CdSe quantum dots (QDs), with an average diameter less than 10 nm, using radio-frequency magnetron sputtering (RFMS) on glass and silicon substrates at 25 °C. First, results show that a target-substrate distance of 13.5 cm and a chamber pressure of 2.2 .10-1 mbar were required to deposit a CdSe QDs layer on the substrates. The morphology and optical properties of CdSe QDs were then studied as a function of RF power and deposition time. The size of CdSe QDs increases with increasing both the RF power and the deposition time. UV-visible spectroscopy shows that the CdSe QDs layer deposited on the glass-substrate by RFMS has almost the same optical properties as the one obtained from commercial CdSe QDs solutions. In both cases, a shift of the characteristic absorption band of CdSe QDs towards the higher wavenumbers is observed with the QDs size increase. AFM confirms the success of CdSe QDs layer deposition by RFMS: CdSe QDs with a mean diameter of 7.5 ± 2 nm were observed for a RF power of 14 W, a chamber pressure of 2.2 .10-1 mbar, a target-substrate distance of 13.5 cm and a deposition time of 7.5 min (optimal values). With these parameters, the coverage of the substrate by the nano-objects is estimated at 25-30 % of the overall surface. [less ▲]

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See detailDu meurtre commis pour faciliter le vol : considérations critiques
Jacques, Elodie ULg

in Revue de Droit Pénal et de Criminologie (2016)

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See detailUse of a multivariate moving window PCA for the untargeted detection of contaminants in agro-food products, as exemplified by the detection of melamine levels in milk using vibrational spectroscopy.
Fernandez Pierna, Juan A; Vincke, Damien; Baeten, Vincent et al

in Chemometrics and Intelligent Laboratory Systems (2016)

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See detailThe Changing Landscape of Smoldering Multiple Myeloma: A European Perspective
CAERS, Jo ULg; de Larrea, Carlos; Leleu, Xavier et al

in Oncologist (2016), 21

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating ... [more ▼]

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with highrisk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention, although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group asMM, and thus will require optimalMMtreatment, based on biomarkers that identify patients with a.80% risk of progression. The number of these redefined patients is small (∼10%), but important to unravel, because their risk of progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-highrisk SMM are now considered as MMand may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation needs to be undertaken. For the greater majority ofSMMpatients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. [less ▲]

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See detailMechanoreceptors in the anterior horn of the equine medial meniscus: an immunohistochemical approach
Nemery, Elodie ULg; Gabriel, Annick ULg; Grulke, Sigrid ULg et al

in Anatomia, Histologia, Embryologia (2016), 45

Lameness due to stifle and especially meniscal lesions is frequent in equine species. In humans, mechanoreceptors involved in proprioceptive function are well studied. Given the high incidence of meniscal ... [more ▼]

Lameness due to stifle and especially meniscal lesions is frequent in equine species. In humans, mechanoreceptors involved in proprioceptive function are well studied. Given the high incidence of meniscal injuries in horses, and the lack of information concerning them in equine menisci, our objective was to study these corpuscles in six healthy anterior horns of the equine medial meniscus, which is the most common localisation reported for equine meniscal injuries. Immunohistochemical stainings were performed using antibodies against high molecular weight neurofilaments and glial fibrillary acidic proteins. From a purely fundamental point of view, our work highlights for the first time the presence of Ruffini, Pacini and Golgi corpuscles in equine meniscus. They were found, isolated or in clusters and always located at the vicinity of blood vessels, at the level of the anterior horn of the equine medial meniscus. This morphological approach could serve as a basis for clinical studies, to evaluate the impact of these corpuscles on the poor sportive prognosis in equine meniscal tears. [less ▲]

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See detailSurfactant-assisted ultrasonic spray pyrolysis of hematite mesoporous thin films
Henrist, Catherine ULg; Toussaint, Caroline ULg; De Vroede, Jordan et al

in Microporous and Mesoporous Materials (2016), 221

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal ... [more ▼]

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal goethiteto-hematite phase transition. In a previous work, it has been reported that with very careful calcination steps, it is possible to prepare mesoporous hematite films with the spin-coating technique. However, with less conventional techniques such as surfactant-assisted ultrasonic spray pyrolysis, the deposition usually leads to non-porous oxide films or to films with interstitial porosity. In this work, we demonstrate for the first time the proof-of-concept of block-copolymer templating of hematite thin films by the ultrasonic spray pyrolysis technique. Despite the fast thermal decomposition during spray deposition, a regular, monodisperse packing of spherical pores is observed after deposition on pre-heated substrates (250 C) and after a careful post-annealing step at 470 C. Moreover, with the use of a silica scaffold, we successfully preserved porosity up to a temperature as high as 800 C. These films are highly crystalline and they are composed by randomly oriented nanocrystallites with sizes as small as 25 nm. Furthermore, we show that the crystallization evolution with temperature is influenced by the presence of the templating agent and also by the preparation technique. [less ▲]

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See detailDementia-specific quality of life instruments: a conceptual analysis
Missotten, Pierre ULg; Dupuis, Gilles; Adam, Stéphane ULg

in International Psychogeriatrics (2016), 28(8), 1245-1262

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the ... [more ▼]

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the conceptual frameworks of the dementia-specific QoL instruments, to identify their evolution over time and to provide elements of reflection on the QoL concept in dementia and its evaluation. Method: An electronic search was conducted on PsycINFO and MEDLINE databases, from January 1985 to June 2015 using a combination of key words that include quality of life, dementia and review. Result: The analysis of the conceptual frameworks of the eighteen selected dementia-specific QoL tools shows a great diversity in: (1) the QoL definitions (e.g. health-related QoL definitions, QoL definitions based on Lawton’s work or similar to this latter); (2) the theoretical QoL models (e.g. Lawton’ work and modified Lawton, adaptation, personhood); (3) the domains and dimensions; (4) the way to construct the instrument (e.g. development based on literature, opinion of the experts) and (5) the items’ formulation (e.g. use of criterion of intensity or frequency). Conclusion: There are different conceptual frameworks in the dementia-specific QoL measures with improvements over time (e.g. inclusion of interesting concepts such as adaptation, taking into account the views of patients themselves). Each of the conceptual parameters (definitions, models, domains and dimensions) is discussed to identify the scales that are conceptually the strongest. Through their review, recommendations for future instrument refinement and development are discussed and a new QoL definition is proposed. [less ▲]

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See detailRisk factors and effect of selective removal on retroviral infections prevalence in Belgian stray cats.
Garigliany, Mutien-Marie ULg; Jolly, Sandra ULg; Dive, M. et al

in The Veterinary record (2016), 178(2), 45

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in ... [more ▼]

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in 302 stray cats captured during a trap-neuter-release programme in a mixed urban-rural area from Belgium, from 2010 to 2012. The impact of selective removal of FIV-positive cats on the apparent prevalence in the remaining population over this three-year period was also assessed. The seroprevalences over three years were 18.8 per cent for FIV and 0.7 per cent for FeLV. For FIV, the seroprevalence decreased significantly from the first year of the programme (2010; 30.5 per cent) to the last (2012; 13.1 per cent). Sex (male) and age (adult and old cats) were risk factors, while the year of sampling (years 2011 and 2012) was a protective factor. Age, sex and location were the most relevant predictors of FIV status. The data presented in this study revealed a very high FIV seroprevalence in Belgian stray cats, while FeLV was almost absent. The selective removal of positive cats had a drastic effect on the FIV seroprevalence in the remaining cat population. [less ▲]

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See detailPhenolic profile, antibacterial and cytotoxic properties of second grade date extract from Tunisian cultivars (Phoenix dactylifera L.)
Kchaou, Wissal; Abbès, Fatma; Ben Mansour, Riadh et al

in Food Chemistry (2016), (194), 1048-1055

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic ... [more ▼]

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic content was analyzed by HPLC. Antimicrobial activity was evaluated by the agar disk diffusion method, and in vitro cytotoxic activity was examined by cell proliferation assay. The results revealed that second grade dates presented three benzoic acids, five cinnamic acids and two flavonoids, with the predominance of q-coumaric acid (1998.80 lg/100 g). The antimicrobial activities showed that the date extracts were active against Gram (+) and Gram (-) bacteria, showing marked activity against Escherichia coli with an inhibition zone of 25 mm. Cytotoxicity assays showed that the date extracts were able to inhibit the proliferation of HeLa cell lines. The results confirmed that the date extracts were rich in biologically active compounds that are highly valued in the functional food and nutraceutical industries. [less ▲]

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See detailExperimental Neospora caninum infection modifies trophoblast cell populations and plasma pregnancy-associated glycoprotein 1 and 2 dynamics in pregnant dairy heifers.
Mur-Novales, R.; Serrano-Perez, B.; Garcia-Ispierto, I. et al

in Veterinary parasitology (2016), 216

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast ... [more ▼]

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast cells, are used for pregnancy diagnosis and as a marker of foetal-placental well-being, while PAG-2, produced by both mono- and binucleate trophoblast cells, may serve as an indicator of abortion risk. In prior work, natural N. caninum infection was found to modify plasma PAG-1 and PAG-2 patterns. The present study examines PAG-1 and PAG-2 dynamics and trophoblast cell populations following experimental infection with N. caninum. The study population was comprised of 17 N. caninum seronegative Holstein-Friesian heifers. On day 110 of gestation, 6 heifers were inoculated intravenously with 10(7) taquyzoites of N. canimum. Plasma samples for PAG-1 and PAG-2 determinations were collected on days 0, 7, 14, 21 and 42 post infection. During the study course, pregnancy was normally expressed in all controls while three infected heifers lost their foetuses. All heifers were euthanised on day 42 post infection and placentome samples from the 14 non-aborting heifers were collected to examine trophoblast cell populations. Plasma PAG-1 and PAG-2 concentrations in non-infected heifers increased until the day of euthanasia while non-aborting infected heifers showed a temporary fall in PAG-1 (P<0.004) and PAG-2 (P<0.002) concentrations from 7 to 14 days post infection (dpi). The two dams aborting at 14 and 21 dpi and a third dam with a mummified foetus upon euthanasia showed dramatic PAG-1 and PAG-2 reductions from 14 dpi to undetectable levels upon euthanasia. A stereological study of placentomes revealed significantly higher relative proportions of mono- (P=0.035) and binucleate (P=0.029) trophoblast cells at 42 dpi in non-infected heifers than infected non-aborting heifers. According to our findings, following experimental N. caninum infection on day 110 of gestation, non-aborting heifers showed a brief reversible drop in plasma PAG-1 and 2 concentrations two weeks later and reduced proportions of bi- and mono-nucleate trophoblast cells 42 days after infection. In aborting dams, dramatically reduced PAG levels were related to severe placental damage and a non-viable pregnancy. [less ▲]

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See detailPHYTOCHEMICAL ANALYSIS OF FUMARIA OFFICINALIS L. (FUMARIACEAE)
Paltinean, Ramona; Toiu, Anca; Wauters, Jean-Noël ULg et al

in Farmacia (2016), 64(3), 409-413

The present study describes the investigation of active compounds from several samples of Fumaria officinalis L. (Fumariaceae). The identification of the isoquinoline alkaloids (allocryptopine ... [more ▼]

The present study describes the investigation of active compounds from several samples of Fumaria officinalis L. (Fumariaceae). The identification of the isoquinoline alkaloids (allocryptopine, chelidonine, protopine, bicuculline, sanguinarine, cheleritrine, stylopine and hydrastine) was performed by comparison with reference standards using an HPLC-DAD method, and their quantification by LC-DAD and spectrophotometric methods. The presence of polyphenolic compounds was simultaneously assessed by HPLC. Protopine and sanguinarine were identified in all extracts. The major alkaloids were protopine and chelidonine (258.3 mg/100 g and respectively 94.13 mg/100 g). The spectrophotometric determinations of alkaloids showed minor differences between commercial samples and those harvested from spontaneous flora. The concentration of isoquinoline alkaloids expressed in chelidonine was between 0.69 and 0.76% in all samples. The pattern of phenol carboxylic acids showed the presence of cynarin, chlorogenic, isochlorogenic and ferulic acids. The flavonoids isovitexin, rutin, isoquercitrin and quercitrin were found in all assessed samples of Fumaria officinalis aerial parts. [less ▲]

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See detailUse of the potential probiotic strain Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers.
Saint-Cyr, Manuel Jimmy; Haddad, Nabila; Taminiau, Bernard ULg et al

in International Journal of Food Microbiology (2016)

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler ... [more ▼]

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler chicken will lower the risk to consumers. The aim of this project was to evaluate the ability of Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers and to investigate the mechanisms that could be involved. Thirty broilers artificially contaminated with C. jejuni were treated by oral gavage with MRS broth or a bacterial suspension (107CFU) of Lb. salivarius SMXD51 (SMXD51) in MRS broth. At 14 and 35days of age, Campylobacter and Lb. salivarius loads were assessed in cecal contents. The impact of the treatment on the avian gut microbiota at day 35 was also evaluated. At day 14, the comparison between the control and treated groups showed a significant reduction (P<0.05) of 0.82 log. After 35days, a significant reduction (P<0.001) of 2.81 log in Campylobacter loads was observed and 73% of chickens treated with the culture exhibited Campylobacter loads below 7log10CFU/g. Taxonomic analysis revealed that SMXD51 treatment induced significant changes (P<0.05) in a limited number of bacterial genera of the avian gut microbiota and partially limited the impact of Campylobacter on Anaerotruncus sp. decrease and Subdoligranulum sp. increase. Thus, SMXD51 exhibits an anti-Campylobacter activity in vivo and can partially prevent the impact of Campylobacter on the avian gut microbiota. [less ▲]

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See detailPhysical, functional and structural characterization of the cell wall fractions from baker's yeast Saccharomyces cerevisiae
Borchani, C.; Fonteyn, F.; Jamin, G. et al

in Food Chemistry (2016), 194

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast ... [more ▼]

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast cell wall fractionation process involving enzymatic treatments (savinase and lipolase enzymes) affected most of the physical and functional characteristics of extracted fractions. Thus, the fractionation process showed that β-D-glucan fraction F4 had significantly higher swelling power and fat binding capacity compared to other fractions (F1, F2 and F3). It also exhibited a viscosity of 652.12 mPa s and a high degree of brightness of extracted β-D-glucan fraction. Moreover, the fractionation process seemed to have an effect on structural and thermal properties of extracted fractions. Overall, results showed that yeast β-D-glucan had good potential for use as a prebiotic ingredient in food, as well as medicinal and pharmaceutical products. © 2015, Elsevier Ltd. All rights reserved. [less ▲]

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See detailRoyseux: a palaeobiodiversity hotspot in the Late Viséan (Carboniferous) of Belgium
Denayer, Julien ULg; Aretz, Markus; Poty, Edouard et al

in Geologica Belgica (2016), 19(1-2), 7-20

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See detailThe CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity
Jourdan, Samuel ULg; Francis, Isolde; Kim, Min et al

in Scientific Reports (2016)

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See detailComparative study of output metrics for A MEMS resonant sensor consisting of three weakly coupled resonators
Zhao, Chun; Wood, Graham; Xie, J.B. et al

in Journal of Microelectromechanical Systems (2016)

Abstract—This paper systematically investigates the characteristics of different output metrics for a weakly coupled three degree-of-freedom microelectromechanical systems resonant sensor. The key figures ... [more ▼]

Abstract—This paper systematically investigates the characteristics of different output metrics for a weakly coupled three degree-of-freedom microelectromechanical systems resonant sensor. The key figures-of-merit examined are sensitivity and linear range. The four main output metrics investigated are mode frequency shift, amplitude difference, amplitude ratio, and eigenstate shift. It is shown from theoretical considerations, equivalent RLC circuit model simulations and electrical measurements, that there is a strong tradeoff between sensitivity and linear range. For instance, the amplitude difference has the best sensitivity but the worst linear range, whereas frequency shift has the widest linear range but the lowest sensitivity. We also show that using the vibrational amplitude ratio as an output metric provides the best balance between sensitivity and linear range. [less ▲]

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See detailCrystallization and polymorphic behavior of enzymatically produced sunflower oil based cocoa butter equivalents
Kadiva, Sheida; De Clercq, Nathalie; Danthine, Sabine ULg et al

in European Journal of Lipid Science and Technology [=EJLST] (2016), 118

A multi-methodological approach was used to study the isothermal crystallization of cocoa butter (CB) in the presence of sunflower oil based cocoa butter equivalents (CBEs). pNMR, DSC, oscillatory ... [more ▼]

A multi-methodological approach was used to study the isothermal crystallization of cocoa butter (CB) in the presence of sunflower oil based cocoa butter equivalents (CBEs). pNMR, DSC, oscillatory rheology, XRD, and PLM were used for this purpose. All the techniques confirmed that at 20°C isothermal crystallization of all the blends is a two-step process with formation of α crystals in the first step and formation of β’ crystals in the second step. The blends with high amount of CBEs contained more high-melting triacylglycerols (TAGs) and diacylglycerol (DAG) in compare with CB acting as seed crystals enhancing the formation of a- crystals in the first crystallization step. Therefore, the induction time of the first crystallization step was inversely related to the amount of CBE. In contrast, the subsequent polymorphic transition was delayed by the presence of the CBE due to their low-melting TAGs. However, adding up to 5% CBE did not change the Foubert’s parameters for isothermal crystallization significantly. All the blends (except 5% HOSO CBE), had a mediated β’ crystallization. Picturing of the microstructure showed that for the CB and the blends up to 50% large microstructures, indicative of the bV polymorph developed during storage. At 100%, a dense network of spherulites was formed at the beginning of the crystallization period, but upon further storage, no large morphological changes were observed. Practical applications: In recent years, the production of CB has been delayed owing to its cultivation difficulty and low yield due to pest attack, while the world cocoa prices have increased with rising demand and higher chocolate consumption. Therefore, there is a need to develop low-priced and appropriate alternatives to CB. Accordingly, in this study two sunflower oil based CBEs were produced with fatty acid mixtures in the presence of immobilized 1,3-regiospecific lipase. The results from this study could help the fats and oils industries to extend their knowledge on the crystallization and polymorphic behavior of two enzymatically produced sunflower oil based CBEs. [less ▲]

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See detailCompte-rendu de l'ouvrage de J. Commaille: A quoi nous sert le droit?
Lejeune, Aude ULg

in Droit et Société (2016)

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See detailCircadian regulation of human cortical excitability
LY, Julien ULg; Gaggioni, Giulia ULg; Chellappa, Sarah et al

in Nature Communications (2016)

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See detailBarley (Hordeum distichon L.) roots synthesise volatile aldehydes with a strong age-dependent pattern and release (E)- non-2-enal and (E,Z)-nona-2,6-dienal after mechanical injury
Delory, Benjamin M.; Delaplace, Pierre ULg; du Jardin, Patrick ULg et al

in Plant Physiology and Biochemistry (2016), 104

In the context of chemical ecology, the analysis of the temporal production pattern of volatile organic compounds (VOCs) in root tissues and the emission rate measurement of root-emitted VOCs are of major ... [more ▼]

In the context of chemical ecology, the analysis of the temporal production pattern of volatile organic compounds (VOCs) in root tissues and the emission rate measurement of root-emitted VOCs are of major importance for setting up experiments to study the implication of these compounds in biotic interactions. Such analyses, however, remain challenging because of the belowground location of plant root systems. In this context, this study describes the evolution of the root VOC production pattern of barley (Hordeum distichon L.) at five developmental stages from germination to the end of tillering and evaluates the emission of the identified VOCs in an artificial soil. VOCs produced by crushed root tissues and released by unexcavated root systems were analysed using dynamic sampling devices coupled to a gas chromatography-mass spectrometry methodology (synchronous SCAN/SIM). The results showed that, at each analysed developmental stage, crushed barley roots produced mainly four volatile aldehydes: hexanal; (E)-hex-2-enal; (E)-non-2-enal; and (E,Z)-nona-2,6-dienal. Higher total and individual VOC concentrations were measured in 3-day-old seminal roots compared with older phenological stages. For each developmental stage, the lipoxygenase (LOX) activity was greater for linoleic acid than α-linolenic acid and the greatest LOX activities using linoleic and α- linolenic acids as substrates were measured in 7- and 3-day-old roots, respectively. The analysis of VOCs released by barley roots into the soil showed that (E)-non-2- enal and (E,Z)-nona-2,6-dienal were the only VOCs emitted in quantifiable amounts by mechanically injured roots. [less ▲]

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See detailRugose corals across the Devonian-Carboniferous boundary in NW Turkey
Denayer, Julien ULg

in Acta Palaeontologica Polonica (2016), 61(1), 51-70

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See detailElectromechanical Sigma-Delta Modulators (EMSDM) force feedback interfaces for capacitive MEMS inertial sensors: a review
Chen, Fang; Li, Xinxin; Kraft, Michael ULg

in IEEE Sensors Journal (2016)

Analog-to-digital converters (ADC) based on sigma-delta modulators (SDM) are a popular choice for high resolution conversion from the analog to the digital domain. With relatively small modifications they ... [more ▼]

Analog-to-digital converters (ADC) based on sigma-delta modulators (SDM) are a popular choice for high resolution conversion from the analog to the digital domain. With relatively small modifications they also can be used as electromechanical SDM (EM-SDM) force feedback interfaces for capacitive micro-electromechanical systems (MEMS) inertial sensors. Such interfaces are able to combine the benefits of force feedback and analog to digital conversion at relatively modest circuit cost. This paper provides a comprehensive review of EM-SDM interfaces for capacitive MEMS inertial sensors. The principle and design methodology of EM-SDM interfaces are introduced. A classification of EM-SDMaccelerometers and gyroscopes is presented, and a detailed analysis of different EM-SDMarchitectures is given. The most representative EM-SDM inertial sensors systems are discussed and compared with regard to their performance characteristics. In particular, the properties of various discrete and continuous-time techniques and a system parameter optimization methodology are illustrated through specific examples. Finally, current challenges and future development trends of EM-SDM interfaces for inertial sensors have been identified. [less ▲]

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See detailThe transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.
Rambout, Xavier ULg; Detiffe, Cecile; Bruyr, Jonathan et al

in Nature Structural & Molecular Biology (2016)

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical ... [more ▼]

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical transcription factors whose previously described functions are confined to the control of mRNA synthesis. Here, we report that ERG also regulates gene expression by affecting mRNA stability and identify the molecular mechanisms underlying this function in human cells. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. Transcriptome-wide mRNA stability analysis revealed that ERG controls the degradation of a subset of mRNAs highly connected to Aurora signaling, whose decay during S phase is necessary for mitotic progression. Our data indicate that control of gene expression by mammalian transcription factors may follow a more complex scheme than previously anticipated, integrating mRNA synthesis and degradation. [less ▲]

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See detailFluorodeoxyglucose F Positron Emission Tomography Coupled With Computed Tomography in Suspected Acute Renal Allograft Rejection.
Lovinfosse, P.; Weekers, L.; Bonvoisin, C. et al

in American Journal of Transplantation (2016)

Management of kidney transplant recipients (KTRs) with suspected acute rejection (AR) ultimately relies on kidney biopsy; however, noninvasive tests predicting nonrejection would help avoid unnecessary ... [more ▼]

Management of kidney transplant recipients (KTRs) with suspected acute rejection (AR) ultimately relies on kidney biopsy; however, noninvasive tests predicting nonrejection would help avoid unnecessary biopsy. AR involves recruitment of leukocytes avid for fluorodeoxyglucose F18 (18 F-FDG), thus 18 F-FDG positron emission tomography (PET) coupled with computed tomography (CT) may noninvasively distinguish nonrejection from AR. From January 2013 to February 2015, we prospectively performed 32 18 F-FDG PET/CT scans in 31 adult KTRs with suspected AR who underwent transplant biopsy. Biopsies were categorized into four groups: normal (n = 8), borderline (n = 10), AR (n = 8), or other (n = 6, including 3 with polyoma BK nephropathy). Estimated GFR was comparable in all groups. PET/CT was performed 201 +/- 18 minutes after administration of 3.2 +/- 0.2 MBq/kg of 18 F-FDG, before any immunosuppression change. Mean standard uptake values (SUVs) of both upper and lower renal poles were measured. Mean SUVs reached 1.5 +/- 0.2, 1.6 +/- 0.3, 2.9 +/- 0.8, and 2.2 +/- 1.2 for the normal, borderline, AR, and other groups, respectively. One-way analysis of variance demonstrated a significant difference of mean SUVs among groups. A positive correlation between mean SUV and acute composite Banff score was found, with r2 = 0.49. The area under the receiver operating characteristic curve was 0.93, with 100% sensitivity and 50% specificity using a mean SUV threshold of 1.6. In conclusion, 18 F-FDG PET/CT may help noninvasively prevent avoidable transplant biopsies in KTRs with suspected AR. [less ▲]

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See detailUn volvulus du sigmoïde: le rôle du radiologue
DEQUIEDT, C; MILICEVIC, Mladen ULg

in Revue Médicale de Liège (2016), 71(5), 252-255

Le volvulus du sigmoïde est la troisième cause d'obstruction colique après le carcinome et la diverticulite (1) dans nos contrées et deviendra une cause encore plus importante dans le futur étant donné sa ... [more ▼]

Le volvulus du sigmoïde est la troisième cause d'obstruction colique après le carcinome et la diverticulite (1) dans nos contrées et deviendra une cause encore plus importante dans le futur étant donné sa prévalence chez les personnes âgées et/ou institutionnalisées. De plus, c’est la première cause d’obstruction intestinale chez la femme enceinte. Étant donné sa clinique peu spécifique, le clinicien doit faire appel aux examens complémentaires et surtout radiographiques pour le diagnostic (2). Le rôle du radiologue est donc primordial dans le diagnostic et pour certains cas dans la thérapeutique du volvulus du sigmoïde. Ceci n’est pas anodin étant donné la morbi/mortalité importante de cette pathologie. Nous vous rapportons ici le cas typique d’un patient de 60 ans se présentant aux urgences pour des vomissements et le ballonnement depuis quelques jours. [less ▲]

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See detailNitrous oxide and methane seasonal variability in the epilimnion of a large tropical meromictic lake (Lake Kivu, East-Africa)
Roland, Fleur ULg; Darchambeau, François ULg; Morana, Cédric et al

in Aquatic Sciences (2016)

We report a data-set of monthly vertical profiles obtained from January 2012 to October 2013, from the surface to 70 m depth of nitrous oxide (N2O) and dissolved methane (CH4) in Lake Kivu, a large and ... [more ▼]

We report a data-set of monthly vertical profiles obtained from January 2012 to October 2013, from the surface to 70 m depth of nitrous oxide (N2O) and dissolved methane (CH4) in Lake Kivu, a large and deep meromictic tropical lake (East Africa). Vertical variations of N2O were modest, with ranges of 6--9 and 0--16 nmol L−1 in surface and bottom waters, respectively, and occasionally peaks of N2O (up to 58 nmol L−1) were observed at the oxic-anoxic interface. On the contrary, steep vertical gradients of CH4 were observed with values changing several orders of magnitude from surface (19--103 nmol L−1) to 70 m (113,000--520,000 nmol L−1). Seasonal variations of CH4 were caused by annual cycles of mixing and stratification, during the dry and rainy seasons, respectively. This mixing allowed the establishment of a thick oxic layer (maximum 65 m deep), leading to decreased CH4 concentrations (minimum of 8 nmol L−1), presumably due to bacterial CH4 oxidation. During the stratification period, the oxic mixed layer was thinner (minimum 25 m deep), and an increase of CH4 concentrations in surface waters was observed (maximum of 103 nmol L−1), probably due to a lower integrated CH4 oxidation on the water column. Lake Kivu seasonally alternated between a source and a sink for atmospheric N2O, but on an annual scale was a small source of N2O to the atmosphere (on average 0.43 \textmumol m−2 day−1), while it was a small source of CH4 to the atmosphere throughout the year (on average 86 \textmumol m−2 day−1). Vertical and seasonal variations of N2O are discussed in terms of nitrification and denitrification, although from the present data-set it is not possible to unambiguously identify the main drivers of N2O production. [less ▲]

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