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See detailYBa2Cu3O7-δ thick films for magnetic shielding: Electrophoretic deposition from butanol-based suspension
Closset, Raphaël ULg; Kumar, Devendra; Wera, Laurent ULg et al

in Materials Letters (2014), 119

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common ... [more ▼]

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common acetone-iodine combination. Tests with several dispersing agents reveal that a branched polyethyleneimine (PEI) dispersant develops large positive surface charge on suspended YBCO particles. As a demonstration of the performance of this new suspension formulation, a 12-layer 100 μm-thick YBCO coating was deposited on an Ag tube. The superconducting transition is sharp with onset critical temperature at 92 K. The sample can shield a magnetic field of ~1.3 mT at 77 K, i.e., the best value so far for an YBCO coating on a metallic substrate. © 2013 Elsevier B.V. [less ▲]

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See detailLA RADIOTHÉRAPIE DANS LE CANCER DU RECTUM CHEZ LA PERSONNE ÂGÉE: Quel bénéfice pour le traitement ?
MARTINIVE, Philippe ULg; ALLEPAERTS, Sophie ULg; VAN DAELE, Daniel ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 47-52

Dans les années à venir, nous serons de plus en plus amenés à prendre en charge des patients âgés en oncologie. Dans ce contexte, quelles sont les évidences scientifiques à notre disposition qui nous ... [more ▼]

Dans les années à venir, nous serons de plus en plus amenés à prendre en charge des patients âgés en oncologie. Dans ce contexte, quelles sont les évidences scientifiques à notre disposition qui nous permettent de prendre en charge de façon correcte cette population oncologique âgée ? Les patients âgés présentent souvent de multiples co-morbidités pouvant interférer avec le traitement oncologique rendant d’autant plus complexe leur prise en charge. Le pic d’inci - dence du cancer du rectum se situe autour des 80 ans, loin au-dessus de l’âge moyen des patients inclus dans les études cliniques. La survie globale des patients traités pour un cancer du rectum s’est améliorée au cours de la dernière décennie, essentiellement pour des patients de moins de 75 ans. Le trai - tement du cancer du rectum nécessite une approche multidis - ciplinaire. L’évaluation gériatrique en fait partie intégrante. Elle permet de définir au mieux la stratégie thérapeutique en fonction de l’état général du patient, de son contexte neuro- psychologique, fonctionnel et social. La radiothérapie joue un rôle majeur dans le traitement du rectum. Quelle est sa place chez les personnes âgées ? Bénéficient-elles également de la radiothérapie, comme la population jeune sélectionnée dans les études contrôlées ? Quel est l’impact de ce traitement sur la qualité de vie ? Voilà des questions essentielles auxquelles nous allons tenter d’apporter une réponse [less ▲]

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See detailImpact of exercise pulmonary hypertension on postoperative outcome in primary mitral regurgitation.
Magne, Julien; Donal, Erwan; Mahjoub, Haifa et al

in Heart (British Cardiac Society) (2014)

AIMS: The management of asymptomatic patients with mitral regurgitation (MR) remains controversial. Exercise-induced pulmonary hypertension (ExPHT) was recently reported as a strong predictor of rapid ... [more ▼]

AIMS: The management of asymptomatic patients with mitral regurgitation (MR) remains controversial. Exercise-induced pulmonary hypertension (ExPHT) was recently reported as a strong predictor of rapid onset of symptoms. We hypothesised that ExPHT is a predictor of postoperative cardiovascular events in patients with primary MR. METHODS AND RESULTS: One hundred and two patients with primary MR, no or mild symptoms (New York heart association (NYHA) </=2), and no LV dysfunction/dilatation, were prospectively recruited in 3 centres and underwent exercise-stress echocardiography. The presence of ExPHT was defined as an exercise systolic pulmonary arterial pressure >60 mm Hg. All patients were closely followed up and operated on when indication for surgery was reached. Postoperative events were defined as the occurrence of atrial fibrillation (AF), stroke, cardiac-related hospitalisation or death. Among the 102 patients included, 59 developed ExPHT (58%). These patients were significantly older than those without ExPHT (p=0.01). During a mean postoperative follow-up of 50+/-23 months, 28 patients (26%) experienced a predefined cardiovascular event. Patients with ExPHT had significantly higher rate of postoperative events (39% vs 12%, p=0.005); the rate of events was still higher in these patients (32% vs 9%, p=0.013), even when excluding early postoperative AF (ie, within 48 h). Event-free survival was significantly lower in the ExPHT group (all events: 5-year: 60+/-8% vs 88+/-5%, p=0.007, events without early AF: 5-year: 67+/-7% vs 90+/-4%, p=0.02). Using Cox multivariable analysis, ExPHT remained independently associated with higher risk of postoperative events in all models (all p</=0.04). CONCLUSIONS: ExPHT is associated with increased risk of adverse cardiac events following mitral valve surgery in patients with primary MR. [less ▲]

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See detailLeptogenesis with a dynamical seesaw scale
Aristizabal Sierra, Diego ULg; Tortola, Maria; Valle, Jose et al

in Journal of Cosmology and Astroparticle Physics [= JCAP] (2014), 2014

In the simplest type-I seesaw leptogenesis scenario right-handed neutrino annihilation processes are absent. However, in the presence of new interactions these processes are possible and can affect the ... [more ▼]

In the simplest type-I seesaw leptogenesis scenario right-handed neutrino annihilation processes are absent. However, in the presence of new interactions these processes are possible and can affect the resulting B-L asymmetry in an important way. A prominent example is provided by models with spontaneous lepton number violation, where the existence of new dynamical degrees of freedom can play a crucial role. In this context, we provide a model-independent discussion of the effects of right-handed neutrino annihilations. We show that in the weak washout regime, as long as the scattering processes remain slow compared with the Hubble expansion rate throughout the relevant temperature range, the efficiency can be largely enhanced, reaching in some cases maximal values. Moreover, the B-L asymmetry yield turns out to be independent upon initial conditions, in contrast to the ''standard'' case. On the other hand, when the annihilation processes are fast, the right-handed neutrino distribution tends to a thermal one down to low temperatures, implying a drastic suppression of the efficiency which in some cases can render the B-L generation mechanism inoperative. [less ▲]

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See detailComparison of two FFPE preparation methods using label-free shotgun proteomics: Application to tissues of diverticulitis patients.
Quesada-Calvo, Florence; Bertrand, Virginie ULg; Longuespée, Rémi ULg et al

in Journal of proteomics (2014), 112C

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic ... [more ▼]

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic biomarkers. However, the critical step in this field is the ability to obtain an efficient and repeatable extraction using the limited quantities of material available for research in hospital biobanks. This work describes the evaluation of the peptide/protein extraction using FFPE sections treated by the following two methods before shotgun proteomic analysis: a commercial solution (FFPE-FASP) (filter aided sample preparation) and an antigen retrieval-derived protocol (On Slice AR). Their efficiencies and repeatabilities are compared using data-independent differential quantitative label-free analysis. FFPE-FASP was shown to be globally better both qualitatively and quantitatively than On Slice AR. FFPE-FASP was tested on several samples, and differential analysis was used to compare the tissues of diverticulitis patients (healthy and inflammatory tissues). In this differential proteomic analysis using retrospective clinical FFPE material, FFPE-FASP was reproducible and provided a high number of confident protein identifications, highlighting potential protein biomarkers. BIOLOGICAL SIGNIFICANCE: In clinical proteomics, FFPE is an important resource for retrospective analysis and for the discovery of biomarkers. The challenge for FFPE shotgun proteomic analysis is preparation by an efficient and reproducible protocol, which includes protein extraction and digestion. In this study, we analyzed two different methods and evaluated their repeatabilities and efficiencies. We illustrated the reproducibility of the most efficient method, FFPE-FASP, by a pilot study on diverticulitis tissue and on FFPE samples amount accessible in hospital biobanks. These data showed that FFPE is suitable for use in clinical proteomics, especially when the FFPE-FASP method is combined with label-free shotgun proteomics as described in the workflow presented in this work. [less ▲]

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See detailRessources naturelles, matières premières et géographie. L'exemple des ressources énergétiques et minières
Deshaies, Michel; Merenne-Schoumaker, Bernadette ULg

in BSGLg (2014), 62

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has ... [more ▼]

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has evolved over time and then analyze new research issues that emerge from a decade. Through this brief analysis, everything indicates a real expansion of fields of investigation, undoubtedly related to the new challenges and opportunities posed by resources that go far beyond the traditional field of economic geography. [less ▲]

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See detailAssessing the potential of an algorithm based on mean climatic data to predict wheat yield
Dumont, Benjamin ULg; Leemans, Vincent ULg; Ferrandis, Salvador et al

in Precision Agriculture (2014)

The real-time non-invasive determination of crop biomass and yield prediction is one of the major challenges in agriculture. An interesting approach lies in using process-based crop yield models in ... [more ▼]

The real-time non-invasive determination of crop biomass and yield prediction is one of the major challenges in agriculture. An interesting approach lies in using process-based crop yield models in combination with real-time monitoring of the input climatic data of these models, but unknown future weather remains the main obstacle to reliable yield prediction. Since accurate weather forecasts can be made only a short time in advance, much information can be derived from analyzing past weather data. This paper presents a methodology that addresses the problem of unknown future weather by using a daily mean climatic database, based exclusively on available past measurements. It involves building climate matrix ensembles, combining different time ranges of projected mean climate data and real measured weather data originating from the historical database or from real-time measurements performed in the field. Used as an input for the STICS crop model, the datasets thus computed were used to perform statistical within-season biomass and yield prediction. This work demonstrated that a reliable predictive delay of 3-4 weeks could be obtained. In combination with a local micrometeorological station that monitors climate data in real-time, the approach also enabled us to (i) predict potential yield at the local level, (ii) detect stress occurrence and (iii) quantify yield loss (or gain) drawing on real monitored climatic conditions of the previous few days. [less ▲]

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See detailNi fantôme ni zombie. L'émergence de la conscience subjective dans le flux des expériences
Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(3), 1-28

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See detailLa Radiothérapie: le parcours du patient, de l’information au traitement
LENNERTS, Eric ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 3-8

La radiothérapie fait partie intégrante de l’arsenal thérapeutique en oncologie et on estime que deux tiers des patients cancéreux vont bénéficier d’une radiothérapie à un moment ou un autre de leur prise ... [more ▼]

La radiothérapie fait partie intégrante de l’arsenal thérapeutique en oncologie et on estime que deux tiers des patients cancéreux vont bénéficier d’une radiothérapie à un moment ou un autre de leur prise en charge. Le parcours d’un patient en radiothérapie est pourtant souvent méconnu du corps médical et le but de cet article est de retracer celui- ci. De la prise de décision de réaliser de la radiothérapie en concertation multidisciplinaire à la délivrance des rayons par les accélérateurs linéaires, il y a la première rencontre avec le radiothérapeute, la simulation, la délimitation des volumes et la planification du traitement. La mise en route d’un trai - tement de radiothérapie demande du temps et beaucoup de précision à chaque étape. Les technologies évoluent constam - ment et la recherche en matière d’amélioration du traitement est une priorité. Le but est d’arriver à adapter individuelle - ment le traitement de radiothérapie. [less ▲]

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See detailNeuronal and psychological underpinnings of pathological gambling
Singer, Bryan F.; Anselme, Patrick ULg; Robinson, Mike J.F. et al

in Frontiers in Behavioral Neuroscience (2014), 8, 230

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See detailFacies characterization of organic-rich mudstones from the Chokier Formation (lower Namurian), south Belgium
Nyhuis, Christian; Rippen, Daniel; Denayer, Julien ULg

in Geologica Belgica (2014), 17(3-4), 311-322

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See detailHead Trauma and Distal Anterior Cerebral Artery Aneurysm: Potential Role of an Adhesion to the Falx
Scholtes, Félix ULg; HENROTEAUX, Adrienne ULg; OTTO, Bernard ULg et al

in Journal of Neurological Surgery. Part A, Central European Neurosurgery (2014), [Epub ahead of print]

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See detailUn complexe d’espèces d’Afzelia des forêts africaines d’intérêt économique et écologique (synthèse bibliographique)
Donkpegan, Segbedji ULg; Hardy, J. Olivier; Lejeune, Philippe ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2),

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The ... [more ▼]

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The distribution of Afzelia species in Africa suggests that the tree has made various adaptations due to ecological factors. However, on the basis of only vegetative criteria, it is difficult to distinguish species in forest inventory, and this could compromise the sustainable management approach promoted by the populations of Central African countries. We show that the genus remains generally understudied, although some of its species are considered by the IUCN as being under threat. Therefore, the ecological and genetic aspects of our investigations should prove relevant to the future cultivation of Afzelia. [less ▲]

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See detailGlobal comparison of light use efficiency models for simulating terrestrial vegetation gross primary production based on the LaThuile database
Yuan, W.; Cai, W.; Xia, J. et al

in Agricultural and Forest Meteorology (2014), 192-193

Simulating gross primary productivity (GPP) of terrestrial ecosystems has been a major challenge in quantifying the global carbon cycle. Many different light use efficiency (LUE) models have been ... [more ▼]

Simulating gross primary productivity (GPP) of terrestrial ecosystems has been a major challenge in quantifying the global carbon cycle. Many different light use efficiency (LUE) models have been developed recently, but our understanding of the relative merits of different models remains limited. Using CO2 flux measurements from multiple eddy covariance sites, we here compared and assessed major algorithms and performance of seven LUE models (CASA, CFix, CFlux, EC-LUE, MODIS, VPM and VPRM). Comparison between simulated GPP and estimated GPP from flux measurements showed that model performance differed substantially among ecosystem types. In general, most models performed better in capturing the temporal changes and magnitude of GPP in deciduous broadleaf forests and mixed forests than in evergreen broadleaf forests and shrublands. Six of the seven LUE models significantly underestimated GPP during cloudy days because the impacts of diffuse radiation on light use efficiency were ignored in the models. CFlux and EC-LUE exhibited the lowest root mean square error among all models at 80% and 75% of the sites, respectively. Moreover, these two models showed better performance than others in simulating interannual variability of GPP. Two pairwise comparisons revealed that the seven models differed substantially in algorithms describing the environmental regulations, particularly water stress, on GPP. This analysis highlights the need to improve representation of the impacts of diffuse radiation and water stress in the LUE models. © 2014 Elsevier B.V. [less ▲]

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See detailBrentano's "Descriptive" Realism
Seron, Denis ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(4), 1-14

Brentano’s metaphysical position in Psychology from an Empirical Standpoint is usually assumed to be metaphysical realism. I propose an alternative interpretation, according to which Brentano was at that ... [more ▼]

Brentano’s metaphysical position in Psychology from an Empirical Standpoint is usually assumed to be metaphysical realism. I propose an alternative interpretation, according to which Brentano was at that time, as well as later, a full-fledged phenomenalist. However, his phenomenalism is markedly different from standard phenomenalism in that it does not deny that the physicist’s judgments are really about the objective world. The aim of the theory of intentionality, I argue, is to allow for extra-phenomenal aboutness within a phenomenalist framework. [less ▲]

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See detailCarotid artery and aortic stiffness evaluation in aortic stenosis.
Weisz, Sara Hana; Magne, Julien ULg; Dulgheru, Raluca et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2014), 27(4), 385-92

BACKGROUND: In aortic stenosis (AS), the combination of risk factors can progressively lead to an increased arterial rigidity, which can be evaluated by the carotid artery and aortic stiffness (beta index ... [more ▼]

BACKGROUND: In aortic stenosis (AS), the combination of risk factors can progressively lead to an increased arterial rigidity, which can be evaluated by the carotid artery and aortic stiffness (beta index). The aim of this study was to investigate the relationship between carotid and aortic beta index, left ventricular (LV) function, plasma brain natriuretic peptide (BNP) level, and symptoms in patients with AS. METHODS: Comprehensive echocardiography including Doppler tissue imaging of the mitral annulus was performed in 53 patients with AS (aortic valve area < 1.2 cm(2)) and preserved LV ejection fractions (>/=50%). Carotid beta index was automatically derived from ultrasound wall tracking of the right carotid artery. The mitral E/e' ratio was used to estimate LV filling pressures. RESULTS: Carotid beta index was higher in women than in men and was significantly correlated with age (P < .0001), diastolic arterial pressure (P = .046), pulse pressure (P = .006), and systemic arterial compliance (P = .001). Interestingly, carotid beta index was significantly correlated with E/e' ratio (P < .0001) and plasma BNP level (P = .011). In multivariate regression analysis, carotid beta index was an independent predictor of E/e' ratio (P < .0001) and of BNP level (P = .02). Moreover, carotid beta index was significantly higher in symptomatic patients (P = .009). Aortic beta index was significantly correlated with carotid beta index (P < .0001), E/e' ratio (P = .004), and BNP (P < .001) and was significantly higher in symptomatic patients (P = .037). CONCLUSIONS: In patients with moderate to severe AS and preserved LV ejection fractions, the presence of increased carotid artery and aortic stiffness, assessed using carotid and aortic beta index, is independently associated with elevated LV filling pressures, BNP level, and symptoms. [less ▲]

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See detailGenotype x Climate interactions for protein yield using four European Holstein Populations
Hammami, Hedi ULg; Carabaño, Maria-Jesus; Logar, Betka et al

in Proceedings of the 10th World Congress on Genetics Applied to Livestock Production (2014)

Reaction norm models were applied to investigate genetic variation in heat tolerance of Holsteins across environments using long term protein milk yield test-day records and weather variables as proxy of ... [more ▼]

Reaction norm models were applied to investigate genetic variation in heat tolerance of Holsteins across environments using long term protein milk yield test-day records and weather variables as proxy of climate change. Data represented four European regions characterized by different management systems and environments. Daily protein yield changed across the trajectory of temperature humidity index (THI) for all studied populations, pointing out negative associations between warm conditions and cow performance. For most regions, additive genetic variances for daily protein yield decrease when THI increases. Antagonistic relationships between level and intercept were relatively limited for Slovenia compared to the three other regions. Rank correlations of estimated breeding values for three proposed heat tolerance measures ranged from 0.56 (Spain and Slovenia) to 0.81 (Walloon Region of Belgium and Luxembourg), indicating a possibility of genotype by environment (G x E) for some pairs of regions. [less ▲]

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See detailRegenerative orthopaedics: in vitro, in vivo ... in silico.
Geris, Liesbet ULg

in International orthopaedics (2014), 38(9), 1771-8

In silico, defined in analogy to in vitro and in vivo as those studies that are performed on a computer, is an essential step in problem-solving and product development in classical engineering fields ... [more ▼]

In silico, defined in analogy to in vitro and in vivo as those studies that are performed on a computer, is an essential step in problem-solving and product development in classical engineering fields. The use of in silico models is now slowly easing its way into medicine. In silico models are already used in orthopaedics for the planning of complicated surgeries, personalised implant design and the analysis of gait measurements. However, these in silico models often lack the simulation of the response of the biological system over time. In silico models focusing on the response of the biological systems are in full development. This review starts with an introduction into in silico models of orthopaedic processes. Special attention is paid to the classification of models according to their spatiotemporal scale (gene/protein to population) and the information they were built on (data vs hypotheses). Subsequently, the review focuses on the in silico models used in regenerative orthopaedics research. Contributions of in silico models to an enhanced understanding and optimisation of four key elements-cells, carriers, culture and clinics-are illustrated. Finally, a number of challenges are identified, related to the computational aspects but also to the integration of in silico tools into clinical practice. [less ▲]

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See detailCouvin/Couvin : Trou de l'Abîme
Miller, Rebecca ULg; Cattelain, Pierre; Otte, Marcel ULg et al

in Chronique de l'Archéologie Wallonne (2014), 21

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See detailDioxins and polychlorinated biphenyls contamination in poultry liver related to food safety - A review
Ghimpeteanu, Oana-Margarita; Militaru, Manuella; Scippo, Marie-Louise ULg

in Food Control (2014), 38

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated ... [more ▼]

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants with high chemical stability; they are lipophilic compounds and they are not destroyed by microbial, photochemical, chemical or thermal degradation. Dioxins and PCBs are ubiquitous environmental contaminants, which are present in all marine plant and animals, birds, mammals and humans and bioaccumulate through the food chain. In the last years, there has been concern regarding food contamination with different chemical substances and their effect on food safety. More particularly, at the end of the 20th and the beginning of the 21st century, there were a series of incidents related to dioxin and PCBs, which directly affected human or contaminated the soil and accumulated in feed and then in food products, such as poultry liver. It was shown in case of dioxin incident that tetra and penta-chlorinated congeners (the most toxic ones) accumulates selectively in poultry livers. Maximal concentrations have been fixed in the European legislation for dioxins and PCBs in food from animal origin, in order to protect the consumer. Data about background poultry liver contamination are scarce and the few available show levels below the legal limit for dioxins, but data are still lacking for DL-PCBs. [less ▲]

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See detailGigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation.
Trivellin, Giampaolo; Daly, Adrian ULg; Faucz, Fabio R. et al

in The New England journal of medicine (2014)

Background Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. Methods We performed ... [more ▼]

Background Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. Methods We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. Results We observed microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism; of these samples, 4 were obtained from members of two unrelated kindreds, and 9 were from patients with sporadic cases. All the patients had disease onset during early childhood. Of the patients with gigantism who did not carry an Xq26.3 microduplication, none presented before the age of 5 years. Genomic characterization of the Xq26.3 region suggests that the microduplications are generated during chromosome replication and that they contain four protein-coding genes. Only one of these genes, GPR101, which encodes a G-protein-coupled receptor, was overexpressed in patients' pituitary lesions. We identified a recurrent GPR101 mutation (p.E308D) in 11 of 248 patients with acromegaly, with the mutation found mostly in tumors. When the mutation was transfected into rat GH3 cells, it led to increased release of growth hormone and proliferation of growth hormone-producing cells. Conclusions We describe a pediatric disorder (which we have termed X-linked acrogigantism [X-LAG]) that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. We also found a recurrent mutation in GPR101 in some adults with acromegaly. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.). [less ▲]

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See detailCell invasion in the spheroid sprouting assay: a spatial organisation analysis adaptable to cell behaviour.
Blacher, Silvia ULg; Erpicum, Charlotte ULg; Lenoir, Benedicte et al

in PLoS ONE (2014), 9(5), 97019

The endothelial cell spheroid assay provides a suitable in vitro model to study (lymph) angiogenesis and test pro- and anti-(lymph) angiogenic factors or drugs. Usually, the extent of cell invasion ... [more ▼]

The endothelial cell spheroid assay provides a suitable in vitro model to study (lymph) angiogenesis and test pro- and anti-(lymph) angiogenic factors or drugs. Usually, the extent of cell invasion, observed through optical microscopy, is measured. The present study proposes the spatial distribution of migrated cells as a new descriptor of the (lymph) angiogenic response. The utility of this novel method rests with its capacity to locally characterise spheroid structure, allowing not only the investigation of single and collective cell invasion but also the evolution of the spheroid core itself. Moreover, the proposed method can be applied to 2D-projected spheroid images obtained by optical microscopy, as well as to 3D images acquired by confocal microscopy. To validate the proposed methodology, endothelial cell invasion was evaluated under different experimental conditions. The results were compared with widely used global parameters. The comparison shows that our method prevents local spheroid modifications from being overlooked and leading to the possible misinterpretation of results. [less ▲]

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See detailEuroEcho-Imaging 2013: highlights.
Lancellotti, Patrizio ULg; Magne, Julien ULg; Cosyns, Bernard et al

in European Heart Journal - Cardiovascular Imaging (2014), 15(5), 483-488

The annual meeting of the European Association of Echocardiography (EuroEcho-Imaging) was held in Istanbul, Turkey. In the present paper, we present a summary of the 'Highlights' session.

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See detailIncrease in dimethylsulfide (DMS) emissions due to eutrophication of coastal waters offsets their reduction due to ocean acidification
Gypens, N; Borges, Alberto ULg

in Frontiers in Marine Science - Marine Ecosystem Ecology (2014), 1(4),

Available information from manipulative experiments suggested that the emission of dimethylsulfide (DMS) would decrease in response to the accumulation of anthropogenic CO2 in the ocean (ocean ... [more ▼]

Available information from manipulative experiments suggested that the emission of dimethylsulfide (DMS) would decrease in response to the accumulation of anthropogenic CO2 in the ocean (ocean acidification). However, in coastal environments, the carbonate chemistry of surface waters was also strongly modified by eutrophication and related changes in biological activity (increased primary production and change in phytoplankton dominance) during the last 50 years. Here, we tested the hypothesis that DMS emissions in marine coastal environments also strongly responded to eutrophication in addition to ocean acidification at decadal timescales. We used the R-MIRO-BIOGAS model in the eutrophied Southern Bight of the North Sea characterized by intense blooms of Phaeocystis that are high producers of dimethylsulfoniopropionate (DMSP), the precursor of DMS. We showed that, for the period from 1951 to 2007, eutrophication actually led to an increase of DMS emissions much stronger than the response of DMS emissions to ocean acidification. [less ▲]

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See detailOrganization of microbeads in Leidenfrost droplet
Maquet, Laurent ULg; Colinet, Pierre; Dorbolo, Stéphane ULg

in Soft Matter (2014), 10

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See detailThe sensitive period for male-to-female sex reversal begins at the embryonic stage in the Nile tilapia and is associated with the sexual genotype
Gennotte, Vincent ULg; Mélard, Charles ULg; D'Cotta, Helena et al

in Molecular Reproduction and Development (2014)

In this study, we sought to determine the mechanism of early sex reversal in a teleost by applying 4 hr feminization treatments to XY (17α-ethynylestradiol 2000 mg L-1) and YY (6500 mg L-1) Nile tilapia ... [more ▼]

In this study, we sought to determine the mechanism of early sex reversal in a teleost by applying 4 hr feminization treatments to XY (17α-ethynylestradiol 2000 mg L-1) and YY (6500 mg L-1) Nile tilapia embryos on the first day post-fertilization (dpf). We then searched for changes in the expression profiles of some sex-differentiating genes in the brain (cyp19a1b, foxl2, and amh) and in sex steroids (testosterone, 17β-estradiol, and 11-ketotestosterone) concentrations during embryogenesis and gonad differentiation. No sex reversal was observed in YY individuals, whereas sex reversal rates in XY progeny ranged from 0-60%. These results, together with the clearance profile of 17α-ethynylestradiol, confirmed the existence of an early sensitive period for sex determination that encompasses embryonic and larval development and is active prior to any sign of gonad differentiation. Estrogen treatment induced elevated expression of cyp19a1b and higher testosterone and 17β-estradiol concentrations at 4 dpf in both XY and YY individuals. foxl2 and amh were repressed at 4 dpf and their expression levels were not different between treated and control groups at 14 dpf, suggesting that foxl2 did not control cyp19a1b in the brains of tilapia embryos. Increased cyp19a1b expression in treated embryos could reflect early brain sexualization, although this difference alone cannot account for the observed sex reversal as the treatment was ineffective in YY individuals. The differential sensitivity of XY and YY genotypes to embryonic induced-feminization suggests that a sex determinant on the sex chromosomes, such as a Y repressor or an X activator, may influence sex reversal during the first steps of tilapia embryogenesis. [less ▲]

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See detailOrganochlorines in harbour porpoises (Phocoena phocoena) stranded along the southern North Sea between 2010 and 2013.
Mahfouz, Celine; Henry, Francoise; Jauniaux, Thierry ULg et al

in Environmental Science. Processes & Impacts (2014), 16(12), 2774-81

7 polychlorinated biphenyls (PCBs), 6 dichlorodiphenyltrichloroethanes (DDXs) and 8 polybrominated diphenyl ethers (PBDEs) were measured in the blubber of 20 harbour porpoises stranded on the coasts of ... [more ▼]

7 polychlorinated biphenyls (PCBs), 6 dichlorodiphenyltrichloroethanes (DDXs) and 8 polybrominated diphenyl ethers (PBDEs) were measured in the blubber of 20 harbour porpoises stranded on the coasts of the southern North Sea between 2010 and 2013. The results showed that porpoises that died from infectious diseases displayed significantly higher levels of PCBs in their blubber compared to healthy porpoises that died from physical trauma. summation operator7CBs and summation operatorDDXs were higher in juvenile porpoises compared to adult females. Except for three individuals, PBDE concentrations were below the limit of quantification in the blubber samples treated. In general, levels of PCBs and DDXs obtained in the blubber of porpoises from this study were in the same order of magnitude or even lower than those obtained in the blubber of porpoises stranded along the North East Atlantic Ocean and the Black Sea over the period 1987 and 2013. The results of the present study suggest that even if the status of marine pollution has been improved, a continuous long-term contamination by toxic organochlorines over many generations may be observed. [less ▲]

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See detailComment comprendre l’influence au sein de groupes d’adolescents ? Le conflit socio-cognitif en appui de la théorie de l’apprentissage social
Mathys, Cécile ULg; Vitaro, Frank; Born, Michel ULg

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2014), 46(2), 289-230

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See detailImpact of anisotropy and viscosity to model the mechanical behavior of Ti-6Al-4V alloy
Tuninetti Vásquez, Victor ULg; Habraken, Anne ULg

in Materials Science and Engineering: A (2014)

This paper compares the predictions of an isotropic-thermo-elasto-viscoplastic approach and of an anisotropic-thermo-elastoplastic one with experimental results representative of the mechanical behavior ... [more ▼]

This paper compares the predictions of an isotropic-thermo-elasto-viscoplastic approach and of an anisotropic-thermo-elastoplastic one with experimental results representative of the mechanical behavior of Ti-6Al-4V at moderate temperatures and low strain rates. The first model is the well known Norton-Hoff viscoplastic constitutive law with isotropic von Mises yield locus identified by using monotonic tension tests performed at strain rates from 10-3 s-1 to 10-1 s-1 and at temperatures up to 400°C. The second model is a thermo-elasto-plastic one defined by the orthotropic yield criterion CPB06. It takes into account the anisotropy and the strength differential (SD) effect in tension-compression of Ti-6Al-4V at RT, 150°C and 400°C. The identification of the SD effect is done by using tension and compression tests and the anisotropy behavior is identified by using shear, plane strain, tension and compression tests performed in three orthogonal material directions. The accuracy of the load and displacements predictions of the two macroscopic constitutive models are compared to experimental results obtained from tests performed on specimens with multiaxial loadings and large strain at several temperatures. [less ▲]

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See detailInitial uncertainty in Pavlovian reward prediction persistently elevates incentive salience and extends sign-tracking to normally unattractive cues
Robinson, Mike J.F.; Anselme, Patrick ULg; Fischer, Adam M. et al

in Behavioural Brain Research (2014), 266(1), 119-130

Uncertainty is a component of many gambling games and may play a role in incentive motivation and cue attraction. Uncertainty can increase the attractiveness for predictors of reward in the Pavlovian ... [more ▼]

Uncertainty is a component of many gambling games and may play a role in incentive motivation and cue attraction. Uncertainty can increase the attractiveness for predictors of reward in the Pavlovian procedure of autoshaping, visible as enhanced sign-tracking (or approach and nibbles) by rats of a metal lever whose sudden appearance acts as a conditioned stimulus (CS+) to predict sucrose pellets as an unconditioned stimulus (UCS). Here we examined how reward uncertainty might enhance incentive salience as sign-tracking both in intensity and by broadening the range of attractive CS+s. We also examined whether initially-induced uncertainty enhancements of CS+ attraction can endure beyond uncertainty itself, and persist even when Pavlovian prediction becomes 100% certain. Our results show that uncertainty can broaden incentive salience attribution to make CS cues attractive that would otherwise not be (either because they are too distal from reward or too risky to normally attract sign-tracking). In addition, uncertainty enhancement of CS+ incentive salience, once induced by initial exposure, persisted even when Pavlovian CS-UCS correlations later rose toward 100% certainty in prediction. Persistence suggests an enduring incentive motivation enhancement potentially relevant to gambling, which in some ways resembles incentive-sensitization. Higher motivation to uncertain CS+s leads to more potent attraction to these cues when they predict the delivery of uncertain rewards. In humans, those cues might possibly include the sights and sounds associated with gambling, which contribute a major component of the play immersion experienced by problematic gamblers. [less ▲]

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See detailThe retirement of the migrant labor force: pension portability and beyond
Jousten, Alain ULg

in CESifo Economic Studies (2014)

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – ... [more ▼]

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – system sustainability or distributive characteristics. The present paper provides a fresh look at the nexus between these two literatures. It discusses the impact of the European social security coordination mechanisms on individual decision-making and on the functioning of social security systems – with a focus on retirement. The paper argues that such effects are non-negligible and are likely to have major policy consequences. [less ▲]

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See detailEarly neuropsychological detection of Alzheimer's disease
Bastin, Christine ULg; Salmon, Eric ULg

in European Journal of Clinical Nutrition (2014), 68

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See detailCharacterization of Black locust (Robinia pseudoacacia L.) heartwood extractives: identification of resveratrol and piceatannol
Sergent, Thérèse; Kohnen, Stéphane; Jourez, Benoît ULg et al

in Wood Science and technology (2014)

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less ... [more ▼]

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less durability against fungi decay, which could be attributed to lower extractive content. In order to elucidate this idea, extractives from mature and juvenile heartwoods of black locust trees were investigated. Results showed that extractive and phenolic contents were higher in mature than in juvenile heartwoods. The identification of phenolic compounds by UPLC–DAD–MS/MS revealed, for the first time, the presence of resveratrol and piceatannol. These two stilbenes as well as the flavonoid dihydrorobinetin were present at the highest level in mature heartwood, and as they are known antifungals, they could account for the great durability of mature heartwood. The stilbenes were detected in significant amounts particularly in mature heartwood where piceatannol reached a level tenfold higher than that reported for Japanese knotweed roots, the primary natural source of these stilbenes, whereas resveratrol level was comparable with reported values. As resveratrol and piceatannol receive increasing demand for nutraceutical, cosmetic and, possibly, pharmaceutical purposes, due to their beneficial health effects, this study underlines the use of R. pseudoacacia as a promising sustainable and economical source of resveratrol and piceatannol. [less ▲]

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See detailLes vergetures, leurs couleurs et leur mécanobiologie.
FRANCHIMONT, Claudine ULg; Peters, S.; Hermanns, J.F. et al

in Revue Médicale de Liège (2014), 69

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See detailPlanatophyton gen. nov., a late Early or Middle Devonian euphyllophyte from Xinjiang, North-West China
Gerrienne, Philippe ULg; Meyer-Berthaud; Yang, N. et al

in Review of Palaeobotany and Palynology (2014)

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See detailReview of Postcolonial Ecologies: Literatures of the Environment edited by Elizabeth DeLoughrey and George B. Handley
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2014), 88(1-2), 182-184

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See detailThe voluntary Code of conduct on invasive alien plants in Belgium: results and lessons learned from the AlterIAS LIFE+ project
Halford, Mathieu ULg; Heemers, L.; van Wesemael, D. et al

in EPPO Bulletin (2014), 44(2), 1-11

Voluntary approaches have been recently used in the horticultural sector to deal with the introduction and spread of invasive alien plants. In Belgium, the first Code of conduct has been developed within ... [more ▼]

Voluntary approaches have been recently used in the horticultural sector to deal with the introduction and spread of invasive alien plants. In Belgium, the first Code of conduct has been developed within the frame of the AlterIAS project, a LIFE+ “Information & Communication” project aiming at raising the awareness of horticulture professionals and gardeners on the invasive plants issue. The Belgian Code was prepared in consultation with representatives from the ornamental sector, public authorities and the scientific community. The Code was promoted throughout the country with a specific communication campaign entitled “Plant different”. Thanks to communication efforts, a positive dynamic of involvement was observed over time. Surveys were performed to assess the changes of attitudes and the perception of the Code by the target audience of the project. Positive results were achieved for horticulture professionals. However, the Code will require more time to be widely adopted by the ornamental sector in Belgium. [less ▲]

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See detailDisease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer.
Andre, Fabrice; Neven, Patrick; Marinsek, Nina et al

in Current medical research and opinion (2014)

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of ... [more ▼]

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of hormonal therapy (HT), and only recommend chemotherapy for patients with extensive visceral involvement or rapidly progressive disease. This study evaluated actual physician-reported treatments for advanced BC in Europe. Methods: We conducted a retrospective chart review of 355 postmenopausal women with HR+, HER2- advanced BC who progressed on >/=1 line of HT (adjuvant or advanced) and completed >/=1 line of chemotherapy (advanced). Treatment choice was evaluated for each line of therapy. Results: Of 355 patients, 111 (31%) received first-line chemotherapy, whereas 218 (61%) and 26 (7%) switched from HT to chemotherapy in second and third line, respectively. More patients receiving first-line HT had bone metastases (73% vs 27% chemotherapy). Patients treated with first-line chemotherapy had more brain (12% vs 3% HT) or extensive liver (13% vs 6% HT) metastases. Subgroup analysis of 188 patients who received first-line HT and had de novo advanced BC or relapsed/recurrent disease more than 1 year after adjuvant therapy found that the majority (89%; n = 167) of these patients switched to chemotherapy in second line. However, among these 167 patients, 27% had no significant changes in metastases between first and second line. Among the 73% of patients who had significant changes in metastases, 20% had no brain metastases or extensive visceral disease. Conclusions: Our study suggests that the guideline-recommended use of multiple HT lines is open to interpretation and that optimal treatment for European postmenopausal women with HR+, HER2- advanced BC who responded to HT may not be achieved. [less ▲]

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See detailGeometric ferroelectricity in fluoroperovskites
Garcia-Castro, A. C.; Spaldin, Nicola A.; Romero, A. H. et al

in Physical Review B (2014), 89

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are ... [more ▼]

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are paraelectric (Pnma phase), we find that many fluoroperovskites have a ferroelectric instability in their high-symmetry cubic structure that is of similar amplitude to that commonly found in oxide perovskites. In contrast to the oxides, however, the fluorides have nominal Born effective charges, indicating a different mechanism for the instability.We show that the instability originates from ionic size effects, and is therefore in most cases largely insensitive to pressure and strain, again in contrast to the oxide perovskites. An exception is NaMnF3, where coherent epitaxial strain matching to a substrate with equal in-plane lattice constants destabilizes the bulk Pnma structure, leading to a ferroelectric, and indeed multiferroic, ground state with an unusual polarization/strain response. [less ▲]

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See detailRecommandations europeennes concernant la therapie de resynchronisation cardiaque.
ROBINET, Sébastien ULg; DELCOUR, Alexandre ULg; Lancellotti, Patrizio ULg

in Revue medicale de Liege (2014), 69(4), 180-7

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In ... [more ▼]

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In this article, we summarize the recommendations of the European Society of Cardiology of 2013 on cardiac resynchronization therapy. [less ▲]

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See detailThe quantified patient: a patient participatory culture.
Appelboom, Geoff; LoPresti, Melissa; Reginster, Jean-Yves ULg et al

in Current medical research and opinion (2014)

Abstract The Quantified Self Movement, which aims to improve various aspects of life and health through recording and reviewing daily activities and biometrics, is a new and upcoming practice of self ... [more ▼]

Abstract The Quantified Self Movement, which aims to improve various aspects of life and health through recording and reviewing daily activities and biometrics, is a new and upcoming practice of self monitoring that holds much promise. Now, the most underutilized resource in ambulatory health care, the patient, can participate like never before, and the patient's Quantified Self can be directly monitored and remotely accessed by health care professionals. [less ▲]

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See detailPréface
Reginster, Jean-Yves ULg

in Best Practice & Research. Clinical Endocrinology & Metabolism (2014), 28

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See detailWomen's skin throughout lifetime.
PIERARD, Gérald ULg; CHARLIER, Corinne ULg; Delvenne, Philippe ULg et al

in BioMed Research International (2014), 2014

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See detailFragmentation and isomerization due to field heating in traveling wave ion mobility
Morsa, Denis ULg; Gabelica, Valérie ULg; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2014), 25(6), 1384-1393

During their travel inside a traveling wave ion mobility cell (TW IMS), ions are susceptible to heating because of the presence of high intensity electric fields. Here, we report effective temperatures T ... [more ▼]

During their travel inside a traveling wave ion mobility cell (TW IMS), ions are susceptible to heating because of the presence of high intensity electric fields. Here, we report effective temperatures T eff,vib obtained at the injection and inside the mobility cell of a SYNAPT G2 HDMS spectrometer for different probe ions: benzylpyridinium ions and leucine enkephalin. Using standard parameter sets, we obtained a temperature of ~800 K at injection and 728 ± 2 K into the IMS cell for p-methoxybenzylpyridinium. We found that T eff,vib inside the cell was dependent on the separation parameters and on the nature of the analyte. While the mean energy of the Boltzmann distributions increases with ion size, the corresponding temperature decreases because of increasing numbers of vibrational normal modes. We also investigated conformational rearrangements of 7+ ions of cytochrome c and reveal isomerization of the most compact structure, therefore highlighting the effects of weak heating on the gas-phase structure of biologically relevant ions. [less ▲]

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See detailFhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.
Joannes, Audrey; Grelet, Simon; Duca, Laurent et al

in Molecular Cancer Research (2014), 12(5), 775-83

In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently decreased or lost. Fhit status has recently been shown to be associated with elevated in vitro and in vivo ... [more ▼]

In many cancers, including lung carcinomas, Fragile histidine triad (Fhit) is frequently decreased or lost. Fhit status has recently been shown to be associated with elevated in vitro and in vivo invasiveness in lung cancer. Tumor cell invasion is facilitated by epithelial-mesenchymal transition (EMT), a process by which tumor cells lose their epithelial features to acquire a mesenchymal cell-like phenotype. In this study, the mechanism underlying Fhit-regulated EMT was deciphered. Using Slug knockdown, pharmacologic inhibitors PD98059, PP1, and gefitinib as well as an anti-EGFR antibody, it was demonstrated that Fhit silencing in bronchial cells induced overexpression of two primary EMT-associated targets, MMP-9 and vimentin, to regulate cell invasion dependent on an EGFR/Src/ERK/Slug signaling pathway. Moreover, ectopic expression of Fhit in Fhit-deficient lung cancer cells downregulated this pathway. Finally, an inverse correlation was observed between Fhit and phospho-EGFR levels in a cohort of human squamous cell lung carcinoma specimens. These results demonstrate a Fhit-dependent mechanism in the control of EMT-regulated EGFR signaling. IMPLICATIONS: This study adds new insight into the regulatory mechanism of EMT, a process known to increase resistance to conventional and targeted therapies in lung cancer. [less ▲]

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See detailCR de Anna Drzewicka, "Volez oïr…". Études sur la littérature française du Moyen Âge, Articles des années 1974-2008
Henrard, Nadine ULg

in Bulletin Bibliographique de la Société Rencesvals (2014), 2013-2014(45), 208-212

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See detailDrug-Drug Interactions with Sodium-Glucose Cotransporters Type 2 (SGLT2) Inhibitors, New Oral Glucose-Lowering Agents for the Management of Type 2 Diabetes Mellitus.
Scheen, André ULg

in Clinical pharmacokinetics (2014)

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. They are proposed as a novel ... [more ▼]

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. They are proposed as a novel approach for the management of type 2 diabetes mellitus. They have proven their efficacy in reducing glycated haemoglobin, without inducing hypoglycaemia, as monotherapy or in combination with various other glucose-lowering agents, with the add-on value of promoting some weight loss and lowering arterial blood pressure. As they may be used concomitantly with many other drugs, we review the potential drug-drug interactions (DDIs) regarding the three leaders in the class (dapagliglozin, canagliflozin and empagliflozin). Most of the available studies were performed in healthy volunteers and have assessed the pharmacokinetic interferences with a single administration of the SGLT2 inhibitor. The exposure [assessed by peak plasma concentrations (C max) and area under the concentration-time curve (AUC)] to each SGLT2 inhibitor tested was not significantly influenced by the concomitant administration of other glucose-lowering agents or cardiovascular agents commonly used in patients with type 2 diabetes. Reciprocally, these medications did not influence the pharmacokinetic parameters of dapagliflozin, canagliflozin or empagliflozin. Some modest changes were not considered as clinically relevant. However, drugs that could specifically interfere with the metabolic pathways of SGLT2 inhibitors [rifampicin, inhibitors or inducers of uridine diphosphate-glucuronosyltransferase (UGT)] may result in significant changes in the exposure of SGLT2 inhibitors, as shown for dapagliflozin and canagliflozin. Potential DDIs in patients with type 2 diabetes receiving chronic treatment with an SGLT2 inhibitor deserve further attention, especially in individuals treated with several medications or in more fragile patients with hepatic and/or renal impairment. [less ▲]

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See detailAvaliação da Qualidade de Vida Infantil: O Inventário Sistémico de Qualidade de Vida para Crianças
Fonseca, Marta; Missotten, Pierre ULg; Etienne, Anne-Marie ULg et al

in Psicologia, Reflexão e Crítica = Psychology, Reflection and Criticism (2014), 27(2),

Introduction: Children’s quality of life evaluation has specific methodological aspects. Objective: To examine the psychometric properties of the Portuguese version of the Child Quality of Life Systemic ... [more ▼]

Introduction: Children’s quality of life evaluation has specific methodological aspects. Objective: To examine the psychometric properties of the Portuguese version of the Child Quality of Life Systemic Inventory (CQLSI), which is based on an innovative conceptual and methodological approach to quality of life self-assessment, namely by being interactive and playful, having a psychometry which operates several scores and allowing an analysis of each domain of life. Methods: 120 Portuguese children, from 8 to 12 years old. Results: Internal consistency of the four scores of the CQLSI (State, Goal, Rank and Gap) is satisfactory; all scores have their own specificity. Data show convergent validity. On the other hand, no satisfactory factorial structure was found. Conclusion: Feasibility and psychometric adequacy of the CQLSI Portuguese version seems demonstrated. [less ▲]

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See detailRecension: "Invloed van het Europese recht op het Belgisch privaatrecht"
Kohl, Benoît ULg

in Droit de la Consommation = Consumentenrecht [= DCCR] (2014), (102), 139-142

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See detailComparison of three 15N methods to correct for microbial contamination when assessing in situ protein degradability of fresh forages
Kamoun, M.; Ammar, H.; Thewis, André ULg et al

in Journal of Animal Science (2014), 92(11), 5053-5062

The use of stable15N as a marker to determine microbial contamination in nylon bag incubation residues to estimate protein degradability was investigated. Three methods using15N were compared:15N-labeled ... [more ▼]

The use of stable15N as a marker to determine microbial contamination in nylon bag incubation residues to estimate protein degradability was investigated. Three methods using15N were compared:15N-labeled forage (dilution method, LF),15N enrichment of rumen solids-associated bacteria (SAB), and 15N enrichment of rumen liquid-associated bacteria (LAB). Herbage from forages differing in protein and fiber contents (early-cut Italian ryegrass, late-cut Italian ryegrass, and red clover) were freeze-dried and ground and then incubated in situ in the rumen of 3 steers for 3, 6, 12, 24, and 48 h using the nylon bag technique. The15N-labeled forages were obtained by fertilizing the plots where herbage was grown with15NH4 15NO3. Unlabeled forages (obtained from plots fertilized with NH4NO3) were incubated at the same time that (15NH4)2SO4 was continuously infused into the rumen of the steers, and then pellets of labeled SAB and LAB were isolated by differential centrifugation of samples of ruminal contents. The proportion of bacterial N in the incubation residues increased from 0.09 and 0.45 g bacterial N/g total N at 3 h of incubation to 0.37 and 0.85 g bacterial N/g total N at 48 h of incubation for early-cut and late-cut ryegrass, respectively. There were differences (P < 0.001) between uncorrected N degradability values and those corrected for microbial contamination with all of the methods. Apparent N degradability of the low-N, high-fiber forage (latecut ryegrass) was 0.51, whereas the corrected values were 0.85, 0.84, and 0.77 for the LF, SAB, and LAB methods, respectively. With early-cut ryegrass and red clover, the differences between uncorrected and corrected values ranged between 6% and 13%, with small differences among the labeling methods. Generally, methods using labeled forage or labeled SAB and LAB provided similar corrected degradability values. The accuracy in estimating the extent of degradation of protein in the rumen from in situ disappearance curves is improved when values are corrected for microbial contamination of the bag residue. [less ▲]

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See detailAnalysis of collagen preservation in bones recovered in archaeological contexts using NIR Hyperspectral Imaging
Vincke, Damien; Miller, Rebecca ULg; Stassart, Edith ULg et al

in Talanta (2014), 125

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen ... [more ▼]

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen preservation in bones recovered from archaeological contexts. This preliminary study has allowed the evaluation of the potential of the method using bone samples from the Early Upper Palaeolithic, Mesolithic and Neolithic periods at the site of Trou Al'Wesse in Belgium. NIR-HCI, combined with chemometric tools, has identified specific spectral bands characteristic of collagen. A chemometric model has been built using Partial Least Squares Discriminant Analysis (PLS-DA) to identify bones with and without collagen. This enables the evaluation of the degree of collagen preservation and homogeneity in bones within and between different strata, which has direct implications for archaeological applications (e.g., taphonomic analyses, assemblage integrity) and sample selection for sub- sequent analyses requiring collagen. Two archaeological applications are presented: comparison between sub-layers in an Early Upper Palaeolithic unit, and evaluation of the range of variability in collagen preservation within a single Holocene stratum. [less ▲]

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See detailSex Differences in Abdominal Aortic Aneurysm: the Role of Sex Hormones.
Makrygiannis, Georgios ULg; Courtois, Audrey ULg; Drion, Pierre ULg et al

in Annals of vascular surgery (2014)

Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in males, whereas women have a greater risk of rupture and more frequently ... [more ▼]

Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in males, whereas women have a greater risk of rupture and more frequently have concomitant thoracic aortic aneurysms. Moreover, women are diagnosed with AAA about 10 years later and seem to be protected by female sex hormones. In this MEDLINE-based review of literature we examined human and animal, in vivo and in vitro studies, to further deepen our understanding of the sexual dimorphism of AAA. We focus on the role of sex hormones during the formation and growth of AAA. Endogenous estrogens and exogenous 17beta-estradiol were found to exert favorable actions protecting from AAA in animal models, whereas exogenous hormone replacement therapy in humans had inconclusive results. Androgens, known to have detrimental effects in the vasculature, in sufficient levels maintain the integrity of the aortic wall through their anabolic actions and act differentially in males and females, whereas lower levels of testosterone have been associated with AAA in humans. In conclusion, sex differences remain an important area of AAA research, but further studies especially in humans are needed. Furthermore, differential molecular mechanisms of sex hormones constitute a potential therapeutic target for AAA. [less ▲]

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See detailLes sons de contact de l'ombrine côtière - Umbrina cirrosa (Linné, 1758)
Lagardère, Jean-Paul; Parmentier, Eric ULg

in Bulletin de la Société de Borda (2014), 514

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See detailRéserve contractile dans l’insuffisance mitrale primaire asymptomatique
PIERARD, Luc ULg; MAGNE, Julien; DULGHERU, Raluca Elena ULg et al

in Revue Médicale de Liège (2014), 69(S2), 8-11

Résumé : L’étude rapportée avait pour but de quantifier la réserve contractile ventriculaire gauche (VG) et d’évaluer son utilité pour la stratification du risque chez les patients asymptomatiques avec ... [more ▼]

Résumé : L’étude rapportée avait pour but de quantifier la réserve contractile ventriculaire gauche (VG) et d’évaluer son utilité pour la stratification du risque chez les patients asymptomatiques avec insuffisance mitrale (IM) primaire. Une échocardiographie au repos et à l’effort, incluant le suivi des marqueurs acoustiques, a été effectuée chez 115 patients consécutifs, présentant une IM primaire modérée ou sévère.La réserve contractile du VG est définie comme une augmentation induite par l’effort de la fraction d’éjection VG ≥ 4% ou de la déformation longitudinale VG ≥ 2%. La réserve contractile VG est absente dans approximativement la moitié de la population. Cette absence est un facteur prédictif indépendant d’événement cardiaque, s’il est évalué par les changements induits par l’effort de la fonction longitudinale VG, mais pas ceux de la fraction d’éjection VG. [less ▲]

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See detailTraining Modifies Innate Immune Responses in Blood Monocytes and in Pulmonary Alveolar Macrophages
Frellstedt, Linda ULg; Waldschmidt, Ingrid; Gosset, Philippe et al

in American Journal of Respiratory Cell and Molecular Biology (2014), 51(1), 135-142

In humans, strenuous exercise causes increased susceptibility to respiratory infections associated with down-regulated expression of Toll-like receptors (TLRs), co-stimulatory and antigen-presenting ... [more ▼]

In humans, strenuous exercise causes increased susceptibility to respiratory infections associated with down-regulated expression of Toll-like receptors (TLRs), co-stimulatory and antigen-presenting molecules. Lower airway diseases are also a common problem in sport and racing horses. Because the innate immunity plays an essential role in lung defense mechanisms, we aimed to assess the effect of acute exercise and training on innate immune responses in two different compartments. Blood monocytes and pulmonary alveolar macrophages (PAM) were collected from horses in an untrained, moderately and intensively trained as well as deconditioned state before and after a strenuous exercise test (SET). The cells were analysed for TLR mRNA expression by real-time PCR in vitro and the cytokine production after in vitro stimulation with TLR ligands was measured by ELISA. Our results showed that training, but not acute exercise, modified the innate immune responses in both compartments. The mRNA expression of TLR3 was down-regulated by training in both cell types, whereas the expression of TLR4 was up-regulated in monocytes. Monocytes treated with lipopolysaccharide (LPS) and a synthetic diacylated lipoprotein (FSL) showed increased cytokine secretion in trained and deconditioned subjects indicating the activation of cells at the systemic level. The production of TNF-alpha and IFN-beta in non-stimulated and stimulated PAM was decreased in trained and deconditioned horses and might therefore explain the increased susceptibility to respiratory infections. Our study reports a dissociation between the systemic and the lung response to training that is probably implicated in the systemic inflammation and in the pulmonary susceptibility to infection. [less ▲]

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See detailGynecologic and obstetric impact of the Ehlers-Danlos syndrome: clues from scrutinizing dermal ultrastructural alterations.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Gynecology (2014), 2(1),

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective ... [more ▼]

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissue fragility. Each EDS type corresponds to a multisystemic disorder with widespread implications. Physicians evoke the EDS diagnosis in presence of some typical cutaneous signs, such as atrophic scars and frequent hematomas. Methods: To revisit the transmission electron microscopy support from skin biopsies when screening EDS in gynecology-obstetrics. Results: EDS women commonly suffer from a series of gynecologic and obstetric disorders. Dermal ultrastructural changes are keynote features suggesting some EDS types. Conclusion: Gene mutations are mostly identified in the classic and vascular EDS types, but only in sporadic cases of the hypermobile EDS type which apparently represents the most frequent type. Dermal ultrastructural changes represent relevant diagnostic clues for the practitioner. Preconception counseling about possible complications is welcome. Management requires precise diagnosis of the EDS type. [less ▲]

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See detailDorsomedial prefrontal metabolism and unawareness of current characteristics of personality traits in Alzheimer’s disease
Jedidi, Haroun ULg; Feyers, Dorothée ULg; Collette, Fabienne ULg et al

in Social Cognitive and Affective Neuroscience (2014)

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while ... [more ▼]

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while unawareness of current characteristics of personality traits has rarely been considered. We used a well-established questionnaire-based method in a group of 37 AD patients and in healthy controls to probe self- and hetero-evaluation of patients’ personality and we calculated differential scores between each participant’s and his/her relative’s judgments. A brain-behavior correlation was performed using FDG-PET images. The behavioral data showed that AD patients presented with anosognosia for current characteristics of their personality and their anosognosia was primarily explained by impaired third perspective taking. The brain-behavior correlation analysis revealed a negative relationship between anosognosia for current characteristics of personality and dorsomedial prefrontal cortex (dMPFC) activity. Behavioral and neuroimaging data are consistent with the view that impairment of different functions subserved by the dMPFC (self-evaluation, inferences regarding complex enduring dispositions of self and others, confrontation of perspectives in interpersonal scripts) plays a role in anosognosia for current characteristics of personality in AD patients. [less ▲]

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See detailLong-term fracture rates seen with continued ibandronate treatment : pooled analysis of DIVA and MOBILE long-term extension studies
Miller, PD; Recker, RR; Harris, S et al

in Osteoporosis International (2014), 25(1), 349-357

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See detailPure and Pseudo-pure Fluid Thermophysical Property Evaluation and the Open-Source Thermophysical Property Library CoolProp
Bell, Ian ULg; Wronski, Jorrit; Quoilin, Sylvain ULg et al

in Industrial & Engineering Chemistry Research (2014), 53

Article Pure and Pseudo-pure Fluid Thermophysical Property Evaluation and the Open-Source Thermophysical Property Library CoolProp ACS ActiveView PDFHi-Res Print, Annotate, Reference QuickView PDF [2027 ... [more ▼]

Article Pure and Pseudo-pure Fluid Thermophysical Property Evaluation and the Open-Source Thermophysical Property Library CoolProp ACS ActiveView PDFHi-Res Print, Annotate, Reference QuickView PDF [2027 KB] PDF w/ Links[457 KB] Full Text HTML Abstract Supporting Info -> Figures Reference QuickView Add to ACS ChemWorx Ian H. Bell *†, Jorrit Wronski *‡, Sylvain Quoilin *†, and Vincent Lemort *† † Energy Systems Research Unit, University of Liège, Liège, Belgium ‡ Department of Mechanical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark Ind. Eng. Chem. Res., 2014, 53 (6), pp 2498–2508 DOI: 10.1021/ie4033999 Publication Date (Web): January 13, 2014 Copyright © 2014 American Chemical Society OpenURL UNIV DE LIEGE *E-mail: ian.bell@ulg.ac.be., *E-mail: jowr@mek.dtu.dk., *E-mail: squoilin@ulg.ac.be., *E-mail: vincent.lemort@ulg.ac.be. ACS AuthorChoice Abstract Over the last few decades, researchers have developed a number of empirical and theoretical models for the correlation and prediction of the thermophysical properties of pure fluids and mixtures treated as pseudo-pure fluids. In this paper, a survey of all the state-of-the-art formulations of thermophysical properties is presented. The most-accurate thermodynamic properties are obtained from multiparameter Helmholtz-energy-explicit-type formulations. For the transport properties, a wider range of methods has been employed, including the extended corresponding states method. All of the thermophysical property correlations described here have been implemented into CoolProp, an open-source thermophysical property library. This library is written in C++, with wrappers available for the majority of programming languages and platforms of technical interest. As of publication, 110 pure and pseudo-pure fluids are included in the library, as well as properties of 40 incompressible fluids and humid air. The source code for the CoolProp library is included as an electronic annex. [less ▲]

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See detailPhysical and biological controls on DMS,P dynamics in ice-shelf influenced fast ice during a winter-spring and a spring-summer transitions
Carnat, G.; Zhou, Jiayun ULg; Papakyriakou, T. et al

in Journal of Geophysical Research. Oceans (2014), 119

We report the seasonal and vertical variations of dimethylsulphide (DMS) and its precursor dimethylsulfoniopropionate (DMSP) in fast ice at Cape Evans, McMurdo Sound (Antarctica) during the spring-summer ... [more ▼]

We report the seasonal and vertical variations of dimethylsulphide (DMS) and its precursor dimethylsulfoniopropionate (DMSP) in fast ice at Cape Evans, McMurdo Sound (Antarctica) during the spring-summer transition in 2011 and winter-spring transition in 2012. We compare the variations of DMS,P observed to the seasonal evolution of the ice algal biomass and of the physical properties of the ice cover, with emphasis on the ice texture and brine dynamics. Isolated DMS and DMSP maxima were found during both seasonal episodes in interior ice and corresponded to the occurrence of platelet crystals in the ice texture. We show that platelet crystals formation corresponded in time and depth to the incorporation of dinoflagellates (strong DMSP producers) in the ice cover. We also show that platelet crystals could modify the environmental stresses on algal cells and perturb the vertical redistribution of DMS,P concentrations. We show that during the winter-spring transition in 2012, the DMS,P profiles were strongly influenced by the development and decline of a diatom dominated bloom in the bottom ice, with DMSP variations remarkably following chl a variations. During the spring-summer transition in 2011, the increase in brine volume fraction (influencing ice permeability) on warming was shown to trigger (1) an important release of DMS to the under-ice water through brine convection (2) a vertical redistribution of DMSP across the ice [less ▲]

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See detailStrategies for Using the Sheep Ovarian Cortex as a Model in Reproductive Medicine
Fransolet, Maïté ULg; Labied, Soraya ULg; Henry, Laurie ULg et al

in PLoS ONE (2014), 9(3), 91073

Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity ... [more ▼]

Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity on the experimental results. Design: Histological study. Setting: Academic research center. Animals: Five- to nine-month-old ewes. Interventions: Freshly sampled whole sheep ovaries were collected and prepared for histological analysis. Main Outcome Measure(s): The follicular densities and distributions were determined for hematoxylin and eosin sections. A mathematical model was derived based on the follicle counts and Monte-Carlo simulations. Results: Heterogeneous distributions and densities of primordial follicles were identified 1) for distinct areas of the same ovarian cortex, 2) between the ovaries of the same animal and 3) across different ewes. A mathematical model based on the analysis of 37,153 primordial follicles from 8 different ovaries facilitated the estimation of the number of cortical biopsies and sections that had to be analyzed to overcome such heterogeneity. Conclusion: The influence of physiological follicular heterogeneity on experimental and clinical results can be overcome when a definite number of cortical pieces and sections are taken into consideration. [less ▲]

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See detailLe point de rosée en berne et la couche cornée hivernale.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; Delvenne, Philippe ULg

in Revue Médicale de Liège (2014), 69(2), 68-71

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed ... [more ▼]

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy. Keywords : Stratum corneum - Dew point [less ▲]

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See detailKluge, Adorno et l’indomptable Leni Peickert
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Cahiers du GRM (2014), 5

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See detailFunctionalization of carbon xerogels for the preparation of palladium supported catalysts applied in sugar transformations
Mager, Nathalie; Meyer, Nathalie; Léonard, Alexandre ULg et al

in Applied Catalysis B : Environmental (2014), 148-149

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See detailAtlantic-Pacific seesaw and its role in outgassing CO2 during Heinrich events
Menviel, L.; England, M.H.; Meissner, K.J. et al

in Paleoceanography (2014), 29

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See detailRating Network Paths for Locality-Aware Overlay Construction and Routing
Du, Wei; Liao, Yongjun ULg; Tao, Narisu et al

in IEEE/ACM Transactions on Networking (2014)

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse ... [more ▼]

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse-grained ratings are appealing in that they are not only informative but also cheap to obtain. Motivated by this insight, we firstly address the scalable acquisition of path ratings by statistical inference. By observing similarities to recommender systems, we examine the applicability of solutions to recommender system and show that our inference problem can be solved by a class of matrix factorization techniques. A technical contribution is an active and progressive inference framework that not only improves the accuracy by selectively measuring more informative paths but also speeds up the convergence for available bandwidth by incorporating its measurement methodology. Then, we investigate the usability of rating-based network measurement and inference in applications. A case study is performed on whether locality awareness can be achieved for overlay networks of Pastry and BitTorrent using inferred ratings. We show that such coarse-grained knowledge can improve the performance of peer selection and that finer granularities do not always lead to larger improvements. [less ▲]

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See detailGenome encyclopaedia of type strains of the genus Bifidobacterium
Milani, Christian; Lugli, Gabriele; Duranti, Sabrina et al

in Applied and Environmental Microbiology (2014)

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See detailMary Anning’s legacy to French vertebrate palaeontology
Vincent, Peggy; Taquet, Philippe; Fischer, Valentin ULg et al

in Geological Magazine (2014), 151(1), 7-20

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent ... [more ▼]

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent study by eminent English and French scientists. In 1820, Georges Cuvier acquired several ichthyosaur specimens found by Mary Anning, now kept or displayed in the Palaeontology Gallery of the MNHN in Paris. Four years later, Cuvier obtained a plesiosaur specimen from Mary Anning, only the second ever discovered. Cuvier was fascinated by these fossils and their study allowed him to apply his comparative anatomical method and to support his catastrophist theory. We re-examined these important specimens from an historical point of view and herein describe them taxonomically for the first time since Cuvier’s works. The Paris specimens belong to two different ichthyosaur genera (Ichthyosaurus and Leptonectes) and one plesiosaur genus (Plesiosaurus). [less ▲]

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See detailLinear electro-optic effect in multiferroic BiFeO3 thin films
Sando, D.; Hermet, Patrick ULg; Allibe, J. et al

in Physical Review B (2014), 89

Multiferroics are materials with coexisting magnetic and ferroelectric orders, which show potential for electrically controlled spintronic devices. A common application of ferroelectrics is in electro ... [more ▼]

Multiferroics are materials with coexisting magnetic and ferroelectric orders, which show potential for electrically controlled spintronic devices. A common application of ferroelectrics is in electro-optical modulators exploiting their electric-field-dependent optical indices. The coupling of optical and magnetic degrees of freedom is attractive for designing multifunctional devices, but to date the electro-optical response of multiferroics has hardly been explored. Here we report a joint experimental and theoretical study of this effect in multiferroic BiFeO3 thin films. We confirm the large birefringence present in single crystals and determine the electro-optic coefficients r13 and r33. We present approaches to increase the obtained coefficients, for instance, by using tetragonal-like BiFeO3, and expand the potential of multiferroics to optical applications. [less ▲]

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See detailRC31, a strong and healthy Research Committee
Martiniello, Marco ULg

in RC-31 Newsletter: ISA International Sociological Association/Research Commitee on Sociology of Migration (2014), (Spring),

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See detailComparative genomics to investigate the evolutionary development of the genus Bifidobacterium
Lugli, Gabriele; Milani, Christian; Turroni, Francesca et al

in Applied and Environmental Microbiology (2014)

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See detailÉtat des lieux des flux céréaliers en Wallonie selon différentes filières d’utilisation
Delcour, Alice ULg; Van Stappen, Florence; Gheysens, Stéphanie et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 181-192

Survey on cereal resources in Wallonia according to their different uses. Survey on cereal resources in Wallonia according to their different uses. More than 60% of the arable cropped area in Wallonia is ... [more ▼]

Survey on cereal resources in Wallonia according to their different uses. Survey on cereal resources in Wallonia according to their different uses. More than 60% of the arable cropped area in Wallonia is dedicated to cereals. Cereal chains were initially aimed at ensuring food security but are now progressively oriented towards new non-food uses. Walloon cereal chains are now having to face up to new global challenges: to ensure the competitiveness and sustainability of vegetal and animal chains, to match society's expectations and to meet the biomass needs for energy uses and bio-based products. Within this framework, this research aims to evaluate the environmental and socio-economic sustainability of future scenarios of current and potential food and non-food uses for Walloon cereals. This paper, the first in a series of two, presents the current picture of Walloon cereal crops and their uses. Various steps are analyzed: production, collection, wholesale and processing. Four main uses characterize cereal processing: the so-called "4Fs", representing Food (human food uses), Feed (animal feed uses), Fuel (energy uses) and Fiber (material uses). Data collected from stakeholders in the Walloon cereal chain enabled us to assess cereal flows for the "4Fs", drawing a qualitative and a quantitative picture of Walloon cereal resources including the key elements of the cereal chains. This approach serves as a basis for a prospective exercise, described in a companion paper, which develops potential uses for Walloon cereal resources at the 2030 horizon. [less ▲]

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See detailBrominated and phosphorus flame retardants in White-tailed Eagle Haliaeetus albicilla nestlings: Bioaccumulation and associations with dietary proxies (δ13C, δ15N and δ34S)
Eulaers, Igor; Jaspers, Veerle; Halley, Duncan et al

in Science of the Total Environment (2014), 478

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation ... [more ▼]

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation potential, and toxicity have been made. We investigated the accumulation of BFRs and PFRs, and their associations with dietary proxies (δ13C, δ15N and δ34S), in plasma and feathers of White-tailed Eagle Haliaeetus albicilla nestlings from Trøndelag, Norway. In addition to accumulation of a wide range of polybrominated diphenyl ether (PBDE) congeners in both plasma and feathers, all non-PBDE BFRs and PFRs could be measured in feathers, while in plasma only two of six PFRs, i.e. tris-(2-chloroisopropyl) phosphate (TCIPP) and tris-(2,3-dichloropropyl) phosphate (TDCPP) were detected. PFR concentrations in feathers (0.95-3,000 ng g-1) were much higher than selected organochlorines (OCs), such as polychlorinated biphenyl 153 (CB 153; 2.3-15 ng g-1) and dichlorodiphenyldichloroethylene (p,p’-DDE; 2.3-21 ng g-1), PBDEs (0.03-2.3 ng g-1) and non-PBDE BFRs (0.03-1.5 ng g-1). Non-significant associations of PFR concentrations in feathers with those in plasma (P≥0.74), and their similarity to reported atmospheric PFR concentrations, may suggest atmospheric PFR deposition on feathers. Most OCs and PBDEs, as well as tris(chloroethyl) phosphate (TCEP), tris(phenyl) phosphate (TPHP) and tri-(2-butoxyethyl) phosphate (TBOEP) were associated to δ15N and/or δ13C (all P≤0.02). Besides δ15N enrichment, δ34S was depleted in nestlings from fjords, inherently close to an urbanised centre. As such, both may have been a spatial proxy for anthropogenic disturbance, possible confounding their use as dietary proxy. [less ▲]

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See detailExtraction by three processes of arabinoxylans from wheat bran and characterization of the fractions obtained
Aguedo, Mario ULg; Fougnies, Christian; DERMIENCE, Michael ULg et al

in Carbohydrate Polymers (2014), 105

Arabinoxylans (AXs) were extracted from destarched wheat bran (DWB) according to different processes, with a view to their production at industrial scale. Two fractions (F3a and F3b, respectively purified ... [more ▼]

Arabinoxylans (AXs) were extracted from destarched wheat bran (DWB) according to different processes, with a view to their production at industrial scale. Two fractions (F3a and F3b, respectively purified on 10 kDa and 100 kDa ultrafiltration membranes) were obtained with low yields by treating DWB with an endoxylanase and this process left a solid residue exhausted in enzyme-extractable AXs (EDWB). F1 and F2 AX fractions were obtained by treatment with sodium hydroxide of respectively DWB and EDWB. The fraction F4 resulted from a hydrothermal treatment of EDWB in a pressure reactor, followed by ethanol precipitation. The different AX fractions were characterized and compared for the composition in monosaccharides, for the contents in fats and in ferulic, phytic and uronic acids, for the molecular mass distribution and the degrees of methylation and acetylation. The alkaline extractions gave one desesterified AX population with molecular mass (MM) higher than 670 kDa and arabinose/xylose ratios (Ara/Xyl) around 1. The enzyme and thermal treatments yielded AXs with two main populations in size-exclusion chromatography (the largest one at 5-12.5 kDa and a second one at 140-160 kDa), having overall Ara/Xyl of respectively 0.7 and 0.5 for both processes. These data bring information about the influence of the process on the characteristics of AX fractions obtained from pretreated wheat bran. Here are also reported processes that enabled to recover enzyme-unextractable AXs from DWB, including an original and up-scalable hydrothermal extraction. Phytate contents of isolated AXs are described for the first time. [less ▲]

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See detailSix leviers pour améliorer l'apprentissage des étudiants du supérieur
Poumay, Marianne ULg

in Revue Internationale de Pédagogie de l'Enseignement Supérieur (2014), 30(1),

Sur base de rapports rédigés par des centaines d’enseignants de l’ULg mais aussi sous l’influence de quelques auteurs en pédagogie universitaire, cet article présente six leviers de l’innovation ... [more ▼]

Sur base de rapports rédigés par des centaines d’enseignants de l’ULg mais aussi sous l’influence de quelques auteurs en pédagogie universitaire, cet article présente six leviers de l’innovation pédagogique dans le supérieur. Nous analysons ensuite une innovation – l’introduction de l’outil « GIC » dans un programme d’orthophonie de l’ULg – au regard de ces six leviers et mentionnons les régulations d’ordre pédagogique et d’ordre organisationnel envisagées pour l’année académique prochaine, de même que quelques pistes de recherche. Une conclusion rappelle le rôle de ces leviers, dont la prise en compte n’est pas une garantie de succès de l’innovation mais plutôt un moteur de changement au sein d’un cours ou d’un programme, gardant le cap sur l’apprentissage de l’étudiant. [less ▲]

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See detailINDICATIONS D’UN TRAITEMENT DE RADIOTHERAPIE LOCALE APRES PROSTATECTOMIE RADICALE
HERMESSE, Johanne ULg; WERENNE, Xavier ULg; PHILIPPI, Sven ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 29-31

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See detailMesozoic marine reptile palaeobiogeography in response to drifting plates
Bardet, Nathalie; Falconnet, Jocelyn; Fischer, Valentin ULg et al

in Gondwana Research (2014)

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically ... [more ▼]

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically, and most were the largest top-predators of the marine ecosystems of their time. The main groups were Ichthyosauria, Sauropterygia, Thalattosauria, and several lineages of Testudinata, Crocodyliformes, Rhynchocephalia and Squamata. Here we show that the palaeobiogeographical distribution of these marine reptiles closely followed the break-up of the supercontinent Pangaea and that they globally used the main marine corridors created by this break-up to disperse. Most Mesozoic marine reptile clades exhibit a cosmopolitan, or at least pandemic, distribution very early in their evolutionary history. The acquisition of morphological adaptations to a fully aquatic life, combined to special thermophysiological characteristics, are probably responsible for these animals to become efficient long-distance open-marine cruisers. Generally, Early Triassic taxa were near-shore animals mainly linked to the Tethys or Panthalassa coastlines. By the end of the Triassic and during the Jurassic, the break-up of Pangaea resulted in the formation of large marine corridors connecting the Tethys to the North Atlantic and Pacific realms, a trend increasing on during the Cretaceous with the expansion of the Atlantic Ocean and the break-up of the southern Gondwana, allowing open-sea marine reptiles to spread out over large distances. However, if large faunal interchanges were possible at a global scale following a dispersal model, some provinces, such as the Mediterranean Tethys, were characterized by a peculiar faunal identity, illustrating an absence of migration with time despite the apparent lack of barriers. So, if Continental Drift enabled global circulations and faunal interchanges via dispersals among Mesozoic marine reptiles, others parameters, such as ecological and biological constraints, probably also played a role in the local endemic distribution of some of these marine groups, as they do today. [less ▲]

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See detailSearch for ReCQL4 mutations in 39 patients genotyped for suspected Rothmund-Thomson/Baller-Gerold syndromes.
Piard, J.; Aral, B.; Vabres, P. et al

in Clinical genetics (2014)

Three overlapping conditions, namely Rothmund-Thomson (RTS), Baller-Gerold (BGS) and RAPADILINO syndromes, have been attributed to RECQL4 mutations. Differential diagnoses depend on the clinical ... [more ▼]

Three overlapping conditions, namely Rothmund-Thomson (RTS), Baller-Gerold (BGS) and RAPADILINO syndromes, have been attributed to RECQL4 mutations. Differential diagnoses depend on the clinical presentation, but the numbers of known genes remain low, leading to the widespread prescription of RECQL4 sequencing. The aim of our study was therefore to determine the best clinical indicators for the presence of RECQL4 mutations in a series of 39 patients referred for RECQL4 molecular analysis and belonging to the RTS (27 cases) and BGS (12 cases) spectrum. One or two deleterious RECQL4 mutations were found in 10/27 patients referred for RTS diagnosis. Clinical and molecular reevaluation led to a different diagnosis in 7/17 negative cases, including Clericuzio-type poikiloderma with neutropenia, hereditary sclerosing poikiloderma, and craniosynostosis/anal anomalies/porokeratosis. No RECQL4 mutations were found in the BGS group without poikiloderma, confirming that RECQL4 sequencing was not indicated in this phenotype. One chromosomal abnormality and one TWIST mutation was found in this cohort. This study highlights the search for differential diagnoses before the prescription of RECQL4 sequencing in this clinically heterogeneous group. The combination of clinically defined subgroups and next-generation sequencing will hopefully bring to light new molecular bases of syndromes with poikiloderma, as well as BGS without poikiloderma. [less ▲]

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See detailOn the observability of the quark orbital angular momentum distribution
Courtoy, Aurore ULg; Goldstein, Gary R.; Hernandez, J. Osvaldo Gonzalez et al

in Physics Letters B (2014), 731(0), 141-147

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See detailHybridization capture using short PCR products enriches small genomes by capturing flanking sequences (CapFlank)
Tsangaras, K.; Wales, N.; Sicheritz-Pontén, T. et al

in PLoS ONE (2014), 9(10),

Solution hybridization capture methods utilize biotinylated oligonucleotides as baits to enrich homologous sequences from next generation sequencing (NGS) libraries. Coupled with NGS, the method generates ... [more ▼]

Solution hybridization capture methods utilize biotinylated oligonucleotides as baits to enrich homologous sequences from next generation sequencing (NGS) libraries. Coupled with NGS, the method generates kilo to gigabases of high confidence consensus targeted sequence. However, in many experiments, a non-negligible fraction of the resulting sequence reads are not homologous to the bait. We demonstrate that during capture, the bait-hybridized library molecules add additional flanking library sequences iteratively, such that baits limited to targeting relatively short regions (e.g. few hundred nucleotides) can result in enrichment across entire mitochondrial and bacterial genomes. Our findings suggest that some of the off-target sequences derived in capture experiments are non-randomly enriched, and that CapFlank will facilitate targeted enrichment of large contiguous sequences with minimal prior target sequence information. [less ▲]

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See detailHeroin-assisted Tx superior to methadone for heroin addiction
Ansseau, Marc ULg

in Medscape medical news (2014)

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See detailEffect of the kinematic hardening in the simulations of the straightening of long rolled profiles
Bouffioux, Chantal ULg; Boman, Romain ULg; Caillet, Nicolas et al

in Key Engineering Materials [=KEM] (2014), 611-612

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are ... [more ▼]

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are straightened using a series of rollers placed alternately above and below the pieces with shifts which create a succession of bendings. The process is modeled to study the impact of the industrial parameters ( the duration of the cooling and the rollers positions), to improve the final geometry and to reduce the residual stresses.Tests are carried out on this structural steel to observe the material behavior, then material laws are chosen and parameters of these laws are defined using and inverse method. Two sets of material data are obtained: for the first one, the hardening is supposed to be isotropic, and for the second one, additional tests are performed to describe isotropic and kinematic hardenings.The cooling followed by the straightening is then simulated by the finite element with these two sets of date. The comparison of the rollers forces, the deformation and the residual stresses show the impact of the kinematic hardening on such a process where the material undergoes a sucession of the tensions and compressions. The real forces applied by the rollers,the real curvature of the interlocks at the end of the straightening process and the distribution of the residual longitudinal stresses measured on the web using the ring core method are used to validate the numerical model. [less ▲]

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See detailThe tumbling spin state of (99942) Apophis
Pravec, P; Scheirich, P; Ďurech, J et al

in Icarus (2014), 233

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See detailPlant defense stimulation by natural isolates of Bacillus depends on efficient surfactin production
Cawoy, Hélène ULg; Mariutto, Martin; Henry, Guillaume et al

in Molecular Plant-Microbe Interactions [=MPMI] (2014), 27

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See detailPrognosis and therapy of tumor-related versus non-tumor-related status epilepticus: a systematic review and meta-analysis.
Arik, Yunus; Leijten, Frans Ss; Seute, Tatjana et al

in BMC neurology (2014), 14

BACKGROUND: Status epilepticus (SE) is a medical emergency with high mortality rates. Of all SE's, 7% are caused by a brain tumor. Clinical guidelines on the management of SE do not make a distinction ... [more ▼]

BACKGROUND: Status epilepticus (SE) is a medical emergency with high mortality rates. Of all SE's, 7% are caused by a brain tumor. Clinical guidelines on the management of SE do not make a distinction between tumor-related SE and SE due to other causes. However, pathophysiological research points towards specific mechanisms of epilepsy in brain tumors. We investigated whether clinical features support a distinct profile of tumor-related SE by looking at measures of severity and response to treatment. METHODS: Systematic review of the literature and meta-analysis of studies on adult SE that report separate data for tumor-related SE and non-tumor-related SE on the following outcomes: short-term mortality, long-term morbidity, duration of SE, and efficacy of anticonvulsant intervention. RESULTS: Fourteen studies on outcome of SE were included. Tumor-related SE was associated with higher mortality than non-tumor-related SE (17.2% versus 11.2%, RR 1.53, 95%-CI 1.24-1.90). After exclusion of patients with hypoxic-ischemic encephalopathy (a group with a known poor prognosis) from the non-tumor-group, the difference in mortality increased (17.2% versus 6.6%; RR 2.78, 95%-CI 2.21 - 3.47). Regarding long-term morbidity and duration of SE there were insufficient data. We did not find studies that systematically compared effects of therapy for SE between tumor- and non-tumor-related SE. CONCLUSIONS: Based on - mostly retrospective - available studies, short-term mortality seems higher in tumor-related SE than in SE due to other causes. Further studies on the outcome and efficacy of different therapeutic regimens in tumor-related SE are needed, to clarify whether tumor-related SE should be regarded as a distinct clinical entity. [less ▲]

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See detailChâteau fort d’Ecaussinnes-Lalaing (Hainaut) : de nouveaux matériaux pour une chronologie du bâti
Maggi, Christophe ULg; Blain, Sophie ULg; Bavay, Gérard et al

in Bulletin de la Commission royale des Monuments, Sites et Fouilles (2014), 25

Situé dans le Hainaut, dominant le vallon de la Senette, le château-fort d’Écaussinnes a fait l’objet de diverses monographies. Pourtant, bien des études du bâti restent à faire, dans la foulée de la plus ... [more ▼]

Situé dans le Hainaut, dominant le vallon de la Senette, le château-fort d’Écaussinnes a fait l’objet de diverses monographies. Pourtant, bien des études du bâti restent à faire, dans la foulée de la plus récente que l’on doit à Philippe Sosnowska. En mars 2012, une étude typologique et dendrochronologique des charpentes, à l’occasion de travaux de restauration aux toitures, apporte quelques éléments nouveaux. L’analyse porte sur les charpentes de toiture de la chapelle et des ailes ouest et nord. Elle a été demandée par les architectes Paul Delaisse et Michel Micciche dans le cadre de la restauration des toitures. [less ▲]

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See detailHost-habitat location by the parasitoid, Nasonia vitripennis Walker (Hymenoptera: Pteromalidae).
Frederickx, Christine ULg; Dekeirsschieter, Jessica ULg; Verheggen, François ULg et al

in Journal of Forensic Sciences (2014), 59

This study investigated the role of odorant cues used during host-habitat location by the generalist parasitoid, Nasonia vitripennis Walker. N vitripennis is a common parasitoid of Dipteran pupae found in ... [more ▼]

This study investigated the role of odorant cues used during host-habitat location by the generalist parasitoid, Nasonia vitripennis Walker. N vitripennis is a common parasitoid of Dipteran pupae found in association with decaying carrion. Behavioral assays were used to investigate the host-habitat searching behavior under different scenarios. First, we demonstrated N. vitripennis to be significantly attracted toward odorant cues associated with decaying meat. The biological activity of nine of the volatile molecules constituting the odor of decaying meat were tested on the searching behavior of parasitoid females through two complementary chemoecological approaches: electronantennography (EAG) and olfactometry bioassays. Butanoic acid and butan-1-ol elicited high olfactory responses, but no attraction was induced by these two chemicals. Behavioral assays showed that, among the VOCs tested, methyldisulfanylmethane (DMDS) was the only volatile chemical to induce attraction in N. vitripennis. [less ▲]

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See detailEvidence for an own-age bias in age estimation from voices in older persons
Moyse, Evelyne ULg; Beaufort, Aline ULg; Brédart, Serge ULg

in European Journal of Ageing (2014)

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the ... [more ▼]

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the occurrence of an own age effect on age estimation from voices has never been examined earlier using an experimental design in which the age of participants (young vs. old) and the age of voice stimuli (young vs. old) were crossed. Results revealed an own-age bias in older adults only. In comparison with younger adults, older participants showed age estimation abilities that are preserved for voices from their own age group and impaired for younger voices. This own age bias was absent in younger participants. [less ▲]

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See detailDoping-dependent band structure of LaAlO3/SrTiO3 interfaces by soft x-ray polarization-controlled resonant angle-resolved photoemission
Cancellieri, C.; Reinle-Schmitt, M.L.; Kobayashi, M. et al

in Physical Review B (2014), 89

Polarization-controlled synchrotron radiation was used to map the electronic structure of buried conducting interfaces of LaAlO3/SrTiO3 in a resonant angle-resolved photoemission experiment. A strong ... [more ▼]

Polarization-controlled synchrotron radiation was used to map the electronic structure of buried conducting interfaces of LaAlO3/SrTiO3 in a resonant angle-resolved photoemission experiment. A strong polarization dependence of the Fermi surface and band dispersions is demonstrated, highlighting different Ti 3d orbitals involved in two-dimensional (2D) conduction. Measurements on samples with different doping levels reveal different band occupancies and Fermi-surface areas.The photoemission results are directly compared with advanced first-principles calculations, carried out for different 3d-band filling levels connected with the 2D mobile carrier concentrations obtained from transport measurements, with indication of charge localization at the interface. [less ▲]

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See detailImmunosuppresseurs dans la prévention de la réaction du greffon contre l'hôte : rapport de la SFGM-TC
Belaiche, S.; Yafour, N.; Balcaen, S. et al

in Pathologie Biologie (2014), 62

In the attempt to harmonize dinical practîces between different French transplantation centers, the Frenell Society of Bane Marrow Transplantation and Cell Therapy (SFGM-TC) set up the fourth annual ... [more ▼]

In the attempt to harmonize dinical practîces between different French transplantation centers, the Frenell Society of Bane Marrow Transplantation and Cell Therapy (SFGM-TC) set up the fourth annual series of workshops which brought together practitioners from all member centers and taak place in September 2013 in Lille. Here we report our recommendatÎons regarding the use of immunosuppressive treatment in the prevention of graft versus hast disease: repOlt by the SFGM-TC. [less ▲]

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See detailMonitoring of osteoporosis therapy
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Best Practice & Research. Clinical Endocrinology & Metabolism (2014), 28

Over the past two decades, major advances have been made in the number and range of agents available for the treatment of osteoporosis, all with proven anti-fracture efficacy. Unfortunately, compliance ... [more ▼]

Over the past two decades, major advances have been made in the number and range of agents available for the treatment of osteoporosis, all with proven anti-fracture efficacy. Unfortunately, compliance with these treatments is not optimal, and a number of patients could be considered as non-responders. Consequently, monitoring anti-osteoporotic therapy could be part of successful osteoporosis management. Currently, no formal well-accepted clinical practice guidelines are available for monitoring anti-osteoporosis therapies. Changes in bone mineral density and bone turnover markers, while on therapy, have potential value in monitoring treatment but their assessment and, consequently, their benefits could be limited by metrological and clinical issues. Moreover, their effectiveness is probably drug dependant. Recommendation for the standardisation of the methodology when analysing the potential relevance of tools for the monitoring of osteoporosis therapy is needed. [less ▲]

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See detailPlanting teak, Tectona grandis L.f., in smallholder farming systems in Southern Benin
Aoudji, Augustin K. N.; Adégbidi, Anselme; Ganglo, Jean C. et al

in Bois et Forêts des Tropiques (2014), (1er trimestre 2014/n° 319), 7-17

This article used the farming system framework to characterise smallholder plantings of teak, Tectona grandis L.f., in southern Benin. The intention of this study was to show the policy line best suited ... [more ▼]

This article used the farming system framework to characterise smallholder plantings of teak, Tectona grandis L.f., in southern Benin. The intention of this study was to show the policy line best suited to capturing the potential of smallholder forestry. The specific question addressed was as follows: how do smallholder farmers manage to integrate tree growing on their farms? Empirical assessments were based on a sample of 221 farmers selected through a cluster sampling procedure in five municipalities in the Atlantic district. Data were collected from face-to-face interviews based on a standardised questionnaire. A multivariate approach associating cluster analysis and Principal Component Analysis (PCA) was used to build a typology of teak planting systems. This was based on production objectives, the teak plantation area, overall farm size and the contribution of family labour to timber production. The study enabled to identify three planting systems related to different strategies for integrating teak planting on smallholdings. These planting systems were classified as “small - labour dominant” (33.48% of the sample), “medium - capital dominant” (37.56%), and “large - capital dominant” (28.96%). The farmers specialised in pole-wood production to supply urban demand for cheap construction timber in the region. The first three motivations for growing teak were to earn income, to satisfy household timber needs and to secure title to the land; however, the ranking of the last two motivations was reversed among farmers in the “large - capital dominant” planting system. Secure land tenure and the existence of a domestic market outlet are essential to successful development of on-farm tree growing. [less ▲]

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See detailFirst Clarkforkian equivalent land mammal age in the latest Paleocene basal Sparnacian facies of Europe: Fauna, flora, paleoenvironment and (bio)stratigraphy
Smith, T.; Quesnel, F.; De Plöeg, G. et al

in PLoS ONE (2014), 9(1),

The Paleocene-Eocene Thermal Maximum (PETM) is correlated with the first occurrences of earliest modern mammals in the Northern Hemisphere. The latest Paleocene Clarkforkian North American Land Mammal Age ... [more ▼]

The Paleocene-Eocene Thermal Maximum (PETM) is correlated with the first occurrences of earliest modern mammals in the Northern Hemisphere. The latest Paleocene Clarkforkian North American Land Mammal Age, that has yielded rodents and carnivorans, is the only exception to this rule. However, until now no pre-PETM localities have yielded modern mammals in Europe or Asia. We report the first Clarkforkian equivalent Land Mammal Age in the latest Paleocene deposits of the basal Sparnacian facies at Rivecourt, in the north-central part of the Paris Basin. The new terrestrial vertebrate and macroflora assemblages are analyzed through a multidisciplinary study including sedimentologic, stratigraphic, isotopic, and palynological aspects in order to reconstruct the paleoenvironment and to evaluate biochronologic and paleogeographic implications. The mammals are moderately diverse and not abundant, contrary to turtles and champsosaurs. The macroflora is exceptional in preservation and diversity with numerous angiosperms represented by flowers, fruits, seeds and wood preserved as lignite material, revealing an abundance of Arecaceae, Betulaceae, Icacinaceae, Menispermaceae, Vitaceae and probably Cornaceae. Results indicate a Late Paleocene age based on carbon isotope data, palynology and vertebrate occurrences such as the choristoderan Champsosaurus, the arctocyonid Arctocyon , and the plesiadapid Plesiadapis tricuspidens. However, several mammal species compare better with the earliest Eocene. Among these, the particular louisinid Teilhardimys musculus, also recorded from the latest Paleocene of the Spanish Pyrenees, suggests a younger age than the typical MP6 reference level. Nevertheless, the most important aspect of the Rivecourt fauna is the presence of dental remains of a rodent and a "miacid" carnivoran, attesting to the presence of two modern mammalian orders in the latest Paleocene of Europe. Interestingly, these two groups are also the only modern groups recorded from the latest Paleocene of North America, making Rivecourt the first direct equivalent to the Clarkforkian Land Mammal Age outside of North America. © 2014 Smith et al. [less ▲]

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