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See detailUncertain altruism and the provision of long term care
Cremer, Helmuth; Gahvari, Firouz; Pestieau, Pierre ULiege

in Journal of Public Economics (2017), 151

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See detailPercevoir et reconnaître des symboles : La théorie de la représentation iconique de Dominic Lopes
Hagelstein, Maud ULiege

in Bulletin d'Analyse Phénoménologique (2017)

In his works on the epistemological value of images (Understanding Pictures — 1996), Dominic Lopes (Department of Philosophy — University of British Columbia) develops an analytical aesthetics primarily ... [more ▼]

In his works on the epistemological value of images (Understanding Pictures — 1996), Dominic Lopes (Department of Philosophy — University of British Columbia) develops an analytical aesthetics primarily concerned with iconic representation. His analysis distinguishes two models of iconic representation comprehension. In the first model, inspired by perceptual approaches like that of Richard Wollheim, the process of image recognition is rooted in perception (to sum it up: perceptualism embraces the idea of « likeness » between the image and what it represents). One of this model’s shortcomings, however, is that it too readily assumes that perception can be a natural, straightforward process. Indeed, iconic representation can not be understood through perception alone, as vision is of course influenced by cultural and, most of all, cognitive processes. A representative model thus needs to account for the ways in which iconic recognition differs from ordinary visual recognition. In the second model, which build off of symbolic approaches like that of Nelson Goodman, iconic representation works the same way as other types of symbols, particularly linguistic ones. Thus, this approach considers the similarities between images and language (representations which are both affected by processes of denotation and predication). However, we all know how strongly image theoreticians have been resisting the linguistic paradigm (iconic turn topic): some worry about overlooking the image’s semantic density in favor of its « simple » descriptive quality. Lopes finds a path between these two models by developing a « theory of aspect recognition », which incorporates perceptive elements into a symbolic structure. According to Lopes, if we agree that images belong to symbolic systems of denotation, then « they might be symbols for which the reference is dependent on the carrying out of perceptive aptitudes », a claim which my talk will explore. I will also discuss how Lopes’ theory accounts for skills acquisition (the capacity to recognize) through images, and shows how images help these skills progressively develop. [less ▲]

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See detailEvidence for a latitudinal diversity gradient in liverworts and hornworts
Wang, J.; Vanderpoorten, Alain ULiege; Hagborg, A. et al

in Journal of Biogeography (2017), 44

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See detailCRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens
Collonnier, Cécile; Epert, Aline; Mara, Kostlend et al

in Plant Biotechnology Journal (2017), 15

The ability to address the CRISPR-Cas9 nuclease complex to any target DNA using customizable single-guide RNAs has now permitted genome engineering in many species. Here, we report its first successful ... [more ▼]

The ability to address the CRISPR-Cas9 nuclease complex to any target DNA using customizable single-guide RNAs has now permitted genome engineering in many species. Here, we report its first successful use in a nonvascular plant, the moss Physcomitrella patens. Single-guide RNAs (sgRNAs) were designed to target an endogenous reporter gene, PpAPT, whose inactivation confers resistance to 2-fluoroadenine. Transformation of moss protoplasts with these sgRNAs and the Cas9 coding sequence from Streptococcus pyogenes triggered mutagenesis at the PpAPT target in about 2% of the regenerated plants. Mainly, deletions were observed, most of them resulting from alternative end-joining (alt-EJ)-driven repair. We further demonstrate that, in the presence of a donor DNA sharing sequence homology with the PpAPT gene, most transgene integration events occur by homology-driven repair (HDR) at the target locus but also that Cas9- induced double-strand breaks are repaired with almost equal frequencies by mutagenic illegitimate recombination. Finally, we establish that a significant fraction of HDR-mediated gene targeting events (30%) is still possible in the absence of PpRAD51 protein, indicating that CRISPR-induced HDR is only partially mediated by the classical homologous recombination pathway. [less ▲]

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See detailA (re)investigation of Middle Kingdom speech captions in wrestling scenes
Motte, Aurore ULiege

in Journal of Egyptian Archaeology (2017), 103(1),

This paper studies the Reden und Rufe present in Middle Kingdom wrestling scenes found in the tombs of Senbi (Meir), Neheri I (Deir el-Bersha), and Khety (Beni Hassan). Based on a systematic study, some ... [more ▼]

This paper studies the Reden und Rufe present in Middle Kingdom wrestling scenes found in the tombs of Senbi (Meir), Neheri I (Deir el-Bersha), and Khety (Beni Hassan). Based on a systematic study, some improvements are suggested to previous translations. After offering commentaries and translation(s) for each speech, the relationship between these scenes and those in Old Kingdom tombs is considered, and distinctive features highlighted. [less ▲]

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See detailRisk assessment for small farmers exposed to plant protection products in the Niger River valley
Massalatchi Illyassou, Karimoun; Adamou, R.; Schiffers, Bruno ULiege

in Communications in Agricultural and Applied Biological Sciences (2017), 81

Plant protection products play a very important role in agriculture. However, their misuse can have serious negative impacts both on human health and environment. A study was carried out to identify the ... [more ▼]

Plant protection products play a very important role in agriculture. However, their misuse can have serious negative impacts both on human health and environment. A study was carried out to identify the plant protection products used in the Niger River valley and to observe the local pesticide management practices. Ten active substances were identified as the most used chemicals by farmers. Their toxicological properties were characterized and their respective Potential Dermal Exposures (PDE) was evaluated in order to assess the risk level for the local small growers. The UK Predictive Operator Exposure Model was used to quantify the PDE during mixing/loading and application according to the local practices. The survey shows that the most common active substances are organophosphate or pyrethroids insecticides. In addition, some other prohibited and counterfeit pesticides cocktails are also used. All active substances used in Niger River valley are highly toxic. When sprayed without personal protective equipment (PPE) they could induce significant harmful impacts on the human health after exposure. The predictive exposure levels vary from 0.0013 mg/kg bw/day to 0.4125 mg/kg bw/day, several times higher the Acceptable Operator Exposure Level (AOEL) for all actives substances. The survey also revealed that 76% of operators do not use any PPE during mixing/loading or spraying. Other bad practices observed in study area can increase the exposure of operators. Moreover, local consumers could also be exposed through intake of pesticide residues on harvested products. [less ▲]

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See detailCorrelations Between Cloud Point and Compositional Properties of Palm Oil and Liquid Fractions from Dry Fractionation
Danthine, Sabine ULiege; Lefebure, Emilie; Blecker, Christophe ULiege et al

in Journal of the American Oil Chemists' Society (2017), 94(6), 841-853

Dry fractionation of palm oil can be conducted as a multi-step process; this gives rise to new softer and harder fractions having multitudes of applications in fat foods. This work focuses on the liquid ... [more ▼]

Dry fractionation of palm oil can be conducted as a multi-step process; this gives rise to new softer and harder fractions having multitudes of applications in fat foods. This work focuses on the liquid fractions obtained following a triple-step fractionation; the cloud point was measured on a set of 125 palm oil, olein, super olein and top olein samples, with the intention to correlate this value to the compositional properties. The Mettler cloud point, the diacylglycerol content, some selected single or groups of triacylglycerols and the iodine value (in total, 11 variables per sample) were measured and entered in a statistical model. A principal component analysis (PCA) was first carried out from which different sub-groups were highlighted. In each sub-group, various regressions (simple linear, simple non-linear and multiple linear) were applied and 28 significant equations were derived. Out of these, one multiple linear regression involving the iodine value, the UUU and PPP contents showed the best correlation with the Mettler cloud point. This equation was selected to predict the cloud point since it was further successfully validated by using a set of 25 other independent samples. A partial least square (PLS) regression was tested and also considered adequate to predict the cloud point. [less ▲]

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See detailAntihypertensive and vasorelaxant effects of aqueous extract of Artemisia campestris L. from Eastern Morocco.
Dib, Ikram; Tits, Monique ULiege; Angenot, Luc ULiege et al

in Journal of Ethnopharmacology (2017), 206

ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia campestris L. (Asteraceae) has many traditional uses, among which treatment of diabetes and hypertension. AIM OF THE STUDY: This study was conducted in order to ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia campestris L. (Asteraceae) has many traditional uses, among which treatment of diabetes and hypertension. AIM OF THE STUDY: This study was conducted in order to confirm the antihypertensive and hypotensive effects of A. campestris L. aqueous extract (AcAE) and to explore the underlying mechanism of action of its vasorelaxant effect, besides the acute toxicity. Also, the chemical composition of AcAE was investigated. MATERIAL AND METHODS: the chemical content of AcAE was determined by using HPLC and NMR techniques. The antihypertensive effect was assessed indirectly by tail-cuff method on L-NAME induced hypertensive rats, while the hypotensive action was monitored intravenously by invasive method on normotensive rats. The vasorelaxant effect and vascular mechanism of action were studied in the presence of antagonists and blockers on aorta isolated from normotensive rats. On the other side, the acute toxicity was studied by oral feeding of extract to the mice. RESULTS: The global phytochemical profile of AcAE reveals the presence of several polyphenols as main components. A. campestris L. infusion was characterized by mono- and di-cinnamoyl compounds, with 3,5-dicaffeoylquinic (isochlorogenic A) acid being the main compound, followed by 5-caffeoylquinic (chlorogenic) acid. Vicenin-2 (apigenin 6,8-di-C-glucoside) appeared to be the most abundant compound among flavonoids. The daily treatment with AcAE at 150mg/Kg/day prevented the installation of hypertension on L-NAME hypertensive rats, and reduced SBP from 172mmHg up to 144mmHg. At the dose 40mg/Kg, AcAE provoked reduction of systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP), without affecting the heart rate. Also, AcAE (10-2-2mg/ml) relaxed the precontracted aorta by 95.8 +/- 1.3%. The denudation and preincubation of aorta with atropine, calmidazolium, L-NAME, hydroxycobalamin, ODQ, 8-RP-Br-PET-cGMP, thapsigargin and verapamil attenuated the vasorelaxant response, while the pre-treatment with 4-AP, TEA, glibenclamide and BaCl2 did not alter this effect. The oral administration of AcAE (0-6g/Kg) reveals no mortality or toxicity. CONCLUSIONS: our study proved that AcAE possess an important antihypertensive, hypotensive and vasorelaxant effect, which is mediated via calmodulin-NO-cGC-PKG pathway, and via inhibition of calcium influx through voltage-operated calcium channels and activation of intracellular calcium mobilization into sarcoplasmic reticulum. Therefore, our findings give first evidence about the traditional use of A. campestris L. as antihypertensive plant. [less ▲]

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See detailAge-dependent reference intervals for estimated and measured glomerular filtration rate
Pottel, Hans; DELANAYE, Pierre ULiege; WEEKERS, Laurent ULiege et al

in Clinical Kidney Journal (2017), 10(4), 545-551

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See detailDisease Note. First Report of Persimmon Cryptic Virus in Spain
Ruiz-Garcia, A-B; Chamberland, N.; Martinez, C. et al

in Journal of Plant Pathology [=JPP] (2017), 99(1),

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See detailEvaluation of the spatial and economic effectiveness of industrial land policies in Northwest Europe
Vandermeer, Marie-Caroline; Halleux, Jean-Marie ULiege

in European Planning Studies (2017)

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e ... [more ▼]

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e. that industrial land policy plays a key role in the creation of growth and new jobs. The article begins with a reflection on the literature, which stresses the need to develop knowledge on industrial land policies. To help fill this research gap, we have developed an exploratory piece of research on the theme of their spatial and economic effectiveness, on the basis of statistical analyses dedicated to seven countries. As regards spatial effectiveness, the results underline significant national differentials in terms of land consumption on the one hand, while highlighting the economic sprawl that affects France and Belgium on the other hand. As regards economic effectiveness, our results show that the impact of the development of economic estates on growth depends largely on regional contexts. In particular, the “intermediate regions” in western Germany stand out as belonging to a specific context where land policies seem particularly effective from an economic standpoint. By contrast, the economic effectiveness of industrial land policies requires readjustments in most “predominantly rural regions, close to a city”. [less ▲]

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See detailRap, antiracisme et identités locales en région liégeoise
Martiniello, Marco ULiege

in Hommes et Migrations (2017), n°1317-1318

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See detailUmbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukemia
Nikolajeva, Olga; Rocha, Vanderson; Danby, Robert et al

in Biology of Blood and Marrow Transplantation (2017)

Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are ... [more ▼]

Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes. We analyzed, retrospectively, the impact of CBU CMV serostatus on relapse incidence (RI) and 2-year nonrelapse mortality (NRM) of single-unit CBU transplantation for acute leukemia. Data from 1177 de novo acute leukemia pediatric and adult patients transplanted within European Group for Blood and Marrow Transplantation centers between 2000 and 2012 were analyzed. CBUs were provided by the European Cord Blood Banks. The median follow-up time for live patients was 59.9 months. The recipients of CMV-seropositive and -seronegative CBUs showed a comparable RI (33% versus 35%, respectively, P = .6) and 2-year cumulative incidence of NRM (31% versus 32%, respectively, P = .5). We conclude that CBU CMV serostatus did not influence RI and NRM in de novo acute leukemia patients after allo-UCBT and should not be included as a criteria for cord blood choice. [less ▲]

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See detailPreterm Infant Growth Velocity Calculations: A Systematic Review
Fenton, Tanis; Chan, Hilton; Madhu, Aiswarya et al

in Pediatrics (2017), 139(3), 1-10

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See detailMixed surfactant systems of sucrose esters and lecithin as a synergistic approach for oil structuring
Bin Sintang, M Dona; Danthine, Sabine ULiege; Patel, Ashok R et al

in Journal of Colloid and Interface Science (2017), 504

In order to modify the self-assembly of sucrose esters (SEs) in sunflower oil, we added sunflower lecithin (SFL) as co-surfactant. It is hypothesized that SFL modifies the selfassembly of SEs by ... [more ▼]

In order to modify the self-assembly of sucrose esters (SEs) in sunflower oil, we added sunflower lecithin (SFL) as co-surfactant. It is hypothesized that SFL modifies the selfassembly of SEs by interrupting the extensive hydrogen bonding between SEs monomers. The addition of SFL into SEs induced gelation of the mixed surfactant system oleogels at all studied ratios. The 7:3 SEs:SFL combination showed enhanced rheological properties compared to the other studied ratios, which suggests better molecular ordering induced by SFL. The modifications might have been caused by interference in the hydrogen bonding, connecting the polar heads of SEs molecules in the presence of SFL. This effect was confirmed by thermal behavior and small angle x-ray diffraction (SAXD) analysis. From the crystallization and melting analyses, it was shown that the peak temperature, shape and enthalpy decreased as the SFL ratio increases. Meanwhile, the bi-component oleogels exhibited new peaks in the SAXD profile, which imply a self-assembly modification. The microscopic study through polarized and electrons revealed a change in the structure. Therefore, it can be concluded that a synergistic effect between SEs and SFL, more particularly at 7:3 ratio, towards sunflower oil structuring could be obtained. These findings shed light for greater applications of SEs as structuring and carrier agent in foods and pharmaceutical. [less ▲]

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See detailPest regulation and support of natural enemies in agriculture: Experimental evidence of within field wildflower strips
Hatt, Séverin ULiege; Chevalier Mendes Lopes, Thomas ULiege; Boeraeve, Fanny ULiege et al

in Ecological Engineering (2017), 98

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for ... [more ▼]

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for today’sagriculture. The aim of this study was to assess whether the two strategies of complicating the search ofhost plants by pests by increasing plant diversity, and of supporting their natural enemies by managinghabitats, could be combined simultaneously at the field scale to restore biological pest control and reducechemical insecticide use. In Gembloux (Belgium), wildflower strips (WFS) were sown within wheat cropsin which pests (i.e., aphids), their predators (i.e. aphidophagous hoverflies, lacewings and ladybeetles)and parasitoid wasps were monitored for 10 weeks in the period of May through July 2015 as indicatorsof the ES of pest control. Aphids were significantly reduced and adult hoverflies favoured in wheat inbetween WFS, compared to monoculture wheat plots. No significant differences were observed for adultlacewings, ladybeetles and parasitoids. In all treatments, very few lacewing and ladybeetle larvae wereobserved on wheat tillers. The abundance of hoverfly larvae was positively correlated with the aphid den-sity on tillers in between WFS, showing that increasing food provisions by multiplying habitats withinfields, and not only along margins, can help supporting aphidophagous hoverflies in crops. By enhancingthe ecosystem services of biological pest control, this study shows that increasing both plant diversityand managing habitats for natural enemies may reduce aphid populations, hence insecticide use. Futureresearch should continue this vein of work by quantifying the link between agricultural practices and thedelivery of ecosystem services in order to guide future measures of agricultural policies. [less ▲]

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See detailUpgrading opportunities in agricultural value chains: Lessons from the analysis of the consumption of processed pineapple products in southern Benin
Aoudji, Augustin K.N.; Avocevou-Ayisso, Carole; Adégbidi, Anselme et al

in African Journal of Science, Technology, Innovation and Development (2017), 2017

This study analyzed the consumption of processed pineapple products in southern Benin. The low processing of agricultural products does not enable sub-Saharan Africa to exploit the potential of ... [more ▼]

This study analyzed the consumption of processed pineapple products in southern Benin. The low processing of agricultural products does not enable sub-Saharan Africa to exploit the potential of agriculture for development. The objective of this paper was to identify upgrading opportunities in Benin’s pineapple value chain. A survey was carried out from December 2012 to February 2013 among 250 respondents randomly selected in five cities in southern Benin; and data were collected based on structured interviews. Dried pineapple, jam, syrup, juice, and cocktail were the processed pineapple products available on the market. Beverages, especially the juice, were the main processed pineapple products. The motivations driving the purchase of processed pineapple beverages by consumers were: competitive price and interest in local, natural and therapeutic beverages. The results indicate there is a margin for the value chain to upgrade products and services, and increase the price of pineapple-based products while staying competitive. A strong marketing and advertisement campaign is essential to support wider knowledge of processed pineapple products by consumers. Product traceability is a prerequisite for export in regional and international markets. This makes the certification of the value chain a critical issue. A joint action of value chain stakeholders is needed to exploit these opportunities. [less ▲]

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See detailRoad and intermodal transport performance: the impact of operational costs and air pollution external costs
Mostert, Martine ULiege; Caris, An; Limbourg, Sabine ULiege

in Research in Transportation Business & Management (2017)

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that ... [more ▼]

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that are not necessarily taken into account in public transportation policies and in private transportation decisions of companies and individuals. This leads to inefficient transportation systems where the social equilibrium is not reached. Intermodal transport is promoted by the European Commission to reduce these negative externalities. The objective of this paper is to analyze at a strategic level the effect on modal split between road, intermodal rail and intermodal inland waterway transport of several economic or environmental policies. An intermodal allocation model is applied to the Belgian case in order to identify the modal split changes between the single minimization of costs (operational or health-related external) and the introduction of additional road taxes. [less ▲]

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See detailBiogeochemical protocols and diagnostics for the CMIP6 Ocean Model Intercomparison Project (OMIP)
Orr, J. C.; Najjar, R. G.; Aumont, O. et al

in Geoscientific Model Development [=GMD] (2017), 10(6), 2169-2199

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See detailDual-Specificity Phosphatase Deletion Protects Female, but Not Male, Mice from Endotoxemia- and Polymicrobial-Induced Septic Shock
Vandereyken, Maud; Singh, Pratibha; Wathieu, Caroline ULiege et al

in Journal of Immunology (2017)

Dual-specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly known physiological functions and for which only a few substrates are known. Using DUSP3-deficient mice, we recently reported that ... [more ▼]

Dual-specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly known physiological functions and for which only a few substrates are known. Using DUSP3-deficient mice, we recently reported that DUSP3 deficiency confers resistance to endotoxin- and polymicrobial-induced septic shock. We showed that this protection was macrophage dependent. In this study, we further investigated the role of DUSP3 in sepsis tolerance and showed that the resistance is sex dependent. Using adoptive-transfer experiments and ovariectomized mice, we highlighted the role of female sex hormones in the phenotype. Indeed, in ovariectomized female and male mice, the dominance of M2-like macrophages observed in DUSP32/2 female mice was reduced, suggesting a role for this cell subset in sepsis tolerance. At the molecular level, DUSP3 deletion was associated with estrogen dependent decreased phosphorylation of ERK1/2 and Akt in peritoneal macrophages stimulated ex vivo by LPS. Our results demonstrate that estrogens may modulate M2-like responses during endotoxemia in a DUSP3-dependent manner. [less ▲]

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See detailHow do we understand smart cities? An evolutionary perspective
Kummitha, Rama; Crutzen, Nathalie ULiege

in Cities : The International Journal of Urban Policy and Planning (2017), 67

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See detailEchocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study
Sugimoto, T; DULGHERU, Raluca Elena ULiege; BERNARD, Anne-Catherine ULiege et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A ... [more ▼]

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean were −16.7% in men and −17.8% in women for longitudinal strain, −22.3% and −23.6% for circumferential strain, 20.6% and 21.5% for radial strain, and 2.2 degrees and 1.9 degrees for twist, respectively. In multivariable analysis, longitudinal strain decreased with age whereas the opposite occurred with circumferential and radial strain. Male gender was associated with lower strain for longitudinal, circumferential, and radial strain. Inter-vendor differences were observed for circumferential and radial strain despite the use of vendor-independent software. Importantly, no intervendor differences were noted in longitudinal strain. Conclusion The NORRE study provides contemporary, applicable 2D echocardiographic reference ranges for LV longitudinal, radial, and circumferential strain. Our data highlight the importance of age- and gender-specific reference values for LV strain. [less ▲]

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See detailVers de nouvelles pistes diagnostiques et thérapeutiques pour l'arthrose chez l'homme
Boulocher, Caroline; Henrotin, Yves ULiege

in Le nouveau praticien vétérinaire canine/féline (2017), 14(65), 7-10

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See detailTrace metals in PG1159 stars and the first identification of metal line forbidden components in astrophysical sources
Werner, K.; Hoyer, D.; Rauch, T. et al

in Astronomical Society of the Pacific Conference Series (2017), 509

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See detailQuality of life assessment in musculo-skeletal health
Beaudart, Charlotte ULiege; Biver, Emmanuel; Bruyère, Olivier ULiege et al

in Aging Clinical and Experimental Research (2017), (Online First),

Musculoskeletal disorders affect morbidity, quality of life and mortality, and represent an increasing economic and societal burden in the context of population aging and increased life expectancy ... [more ▼]

Musculoskeletal disorders affect morbidity, quality of life and mortality, and represent an increasing economic and societal burden in the context of population aging and increased life expectancy. Improvement of quality of life should be one of the priorities of any interventions to prevent and treat musculoskeletal disorders in the ageing population. Two main approaches, namely generic and disease-specific instruments, can be applied to measure health-related quality of life. Among the generic tools available in scientific literature, the short form 36 questionnaire (SF-36) and the Euroqol five item questionnaire (EQ-5D) are two of the most popular questionnaires used to quantify the health related quality of life in people with musculoskeletal disorders. However, because generic tools may not always be able to detect subtle effects of a specific condition on quality of life, a specific tool is highly valuable. Specific tools improve the ability to clinically characterize quality of life in subjects with a specific musculoskeletal disorder, as well as the capacity to assess changes over time in the QoL of these subjects. The recent development of specific tools should help to validate preventive and therapeutic interventions in this field. [less ▲]

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See detailHigh-throughput strategies for the discovery and engineering of enzymes for biocatalysis
Jacques, Philippe ULiege; Béchet, M.; Bigan, M. et al

in Bioprocess and Biosystems Engineering (2017), 40(2),

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See detailRethinking the Memorable Panel from Pierre Sterckx to Olivier Josso Hamel
Crucifix, Benoît ULiege

in European Comic Art (2017), 10(2), 24-47

Going back to the origins of the ‘case mémorable’ in the pages of Les Cahiers de la bande dessinée, this article revisits the debates between Pierre Sterckx and Benoît Peeters, articulated around a ... [more ▼]

Going back to the origins of the ‘case mémorable’ in the pages of Les Cahiers de la bande dessinée, this article revisits the debates between Pierre Sterckx and Benoît Peeters, articulated around a conceptual tension between linear and tabular, about the relationship between single panels and narrative. It proposes that the ‘remembered panel’ pinpoints important issues about the recirculation of single images, isolated from their contexts, and the discourse of memory that becomes associated with it. A close-reading of Olivier Josso Hamel’s Au travail, in which the cartoonist redraws his own set of remembered panels, further calls for a reconsideration of Sterckx’s concept in the light of a creative practice that intimately engages with the memory of such panels in a complex relationship to their original narratives. [less ▲]

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See detailObservations of asymmetric turbulent stirring in inner and marginal seas using satellite imagery
Karimova, Svetlana ULiege

in International Journal of Remote Sensing (2017), 38(6), 1642-1664

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale ... [more ▼]

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale cyclonic and anticyclonic eddies in a number of inner and marginal marine basins, namely in the Baltic, Black, North, and Western Mediterranean Seas. As research material, over 9700 eddy manifestations in the thermal infrared, visible-range, and radar satellite imagery were used. The analysis performed showed that in all the seas the typical and average values of the diameter of anticyclonic eddies were greater than those of cyclonic eddies. The main factor that defines the ratio between anticyclonic and cyclonic eddies in the basins under consideration was discovered to be the intensity of their surface currents. Thus, in the presence of a strong jet flow at the scales of about 2–4 baroclinic Rossby radii the cyclonic eddy dominance typical for smaller eddies was replaced by the anticyclonic one. If strong jet streams were missing, as that typical of the Baltic Sea, cyclonic eddies were prevailing over the entire spectrum of eddy diameters. [less ▲]

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See detailTroubles du comportement alimentaire et régulation émotionnelle
Englebert, Jérôme ULiege

in Psychosomatique Relationnelle (2017), 7

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See detailAlcohol-cue exposure decreases response inhibition towards alcohol-related stimuli in detoxified alcohol-dependent patients
Kreusch, Fanny; Billieux, Joël; Quertemont, Etienne ULiege

in Psychiatry Research (2017), 249

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol ... [more ▼]

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol relapse. The aim of the present study is to investigate whether the induction of a craving state, using an alcohol cue exposure paradigm, influences response inhibition towards both neutral stimuli and alcohol-related stimuli in alcohol-dependent patients. Thirty-one detoxified alcohol-dependent patients were exposed to either their preferred alcoholic beverage or to a glass of water. They then performed a modified stop signal task, which used alcohol-related words, neutral words and non-words, and a lexical decision as the Go response. The alcohol-cue exposure group reported significantly higher alcohol craving and showed higher percentages of commission errors towards alcohol-related words than the control group. All participants, but especially those of the alcohol-cue exposure group, showed also shorter reaction times when alcohol words were used as targets in go trials. The induction of alcohol craving in detoxified alcohol-dependent patients increases the motivational salience value of alcohol stimuli, leading them to automatically approach alcohol-related cues and therefore impairing response inhibition towards those stimuli. [less ▲]

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See detailComparison of clinical effects of epidural levobupivacaine morphine versus bupivacaine morphine in dogs undergoing elective pelvic limb surgery
Cerasoli, Ilaria; Tutunaru, Alexandru-Cosmin ULiege; Cenani, Alessia et al

in Veterinary Anaesthesia & Analgesia (2017)

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See detailOn Sustainable Aquaculture
Tran Thi Nang, Thu; Lebailly, Philippe ULiege

in Oceanography & Fisheries (2017), 1(3), 001-002

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See detailA comparative test of ixodid tick identification by a network of European researchers.
Estrada Pena, Agustin; D'amico, G; Palomar, Ag et al

in Ticks and Tick-borne Diseases (2017), 8(4), 540-546

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See detailLooking beyond general metrics for model comparison – lessons from an international model intercomparison study
de Boer-Euser, Tanja; Bouaziz, Laurène; De Niel, Jan et al

in Hydrology and Earth System Sciences (2017), 21

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for ... [more ▼]

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for international cooperation, they do often not lead to very clear new insights regarding the relevance of the modelled processes. We hypothesise that this is partly caused by model complexity and the comparison methods used, which focus too much on a good overall performance instead of focusing on specific events. In this study, we use an approach that focuses on the evaluation of specific events and characteristics. Eight international research groups calibrated their hourly model on the Ourthe catchment in Belgium and carried out a validation in time for the Ourthe catchment and a validation in space for nested and neighbouring catchments. The same protocol was followed for each model and an ensemble of best performing parameter sets was selected. Although the models showed similar performances based on general metrics (i.e. Nash–Sutcliffe Efficiency), clear differences could be observed for specific events. The results illustrate the relevance of including a very quick flow reservoir preceding the root zone storage to model peaks during low flows and including a slow reservoir in parallel with the fast reservoir to model the recession for the Ourthe catchment. This intercomparison enhanced the understanding of the hydrological functioning of the catchment and, above all, helped to evaluate each model against a set of alternative models. [less ▲]

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See detailMiddle Ordovician acritarchs and problematic organic-walled microfossils from the Saq-Hanadir transitional beds in the QSIM-801 well, Saudi Arabia
Le Hérissé, A.; Guidat, C.; Not, F. et al

in Revue de Micropaléontologie (2017), 60

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See detailSex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure.
van Hemmen, J.; Saris, I. M. J.; Cohen-Kettenis, P. T. et al

in Cerebral cortex (New York, N.Y. : 1991) (2017)

Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the ... [more ▼]

Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extended WM regions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation of WM microstructure, although sex chromosome genes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role. [less ▲]

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See detailThe clinical relevance of imatinib plasma trough concentrations in chronic myeloid leukemia. A Belgian study
Van Obbergh, F; Knoops, L; Devos, T et al

in Clinical Biochemistry (2017), 50

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice ... [more ▼]

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice. Forty-one patients, with 47 imatinib plasma measurements, were analyzed during treatment with imatinib given at a fixed 400mg daily dose. A significant inverse relationship of imatinib concentration with the patients' weight was observed (Pearson's test: p=0.02,R2=0.1). More interestingly, patientswith poor response (switched to another tyrosine kinase inhibitor because of imatinib failure, or because of disease progression after an initial response) displayed a significantly lower mean imatinib concentration as compared to patients maintained on imatinib (822 ng/mL vs 1099 ng/mL; Student's t-test, p=0.04). Failure or disease progression occurred more often in patients in the lowest quartile of imatinib concentrations compared to patients in the highest quartile (p = 0.02, logrank test). No correlation could be established with other biological or clinical parameter, including complete cytogenic response and majormolecular response. In conclusion: in patients treatedwith imatinib at a fixed daily dose of 400 mg, imatinib plasma concentrations decreased with increasing body weight and were lower in patients switched to another tyrosine kinase inhibitor due to imatinib failure. Systematic determination of imatinib plasma trough levels should be encouraged in such patients. [less ▲]

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See detailRelevant Animal Models in Dermatophyte Research
Cambier, Ludivine ULiege; Heinen, Marie-Pierre ULiege; Mignon, Bernard ULiege

in Mycopathologia (2017), 182(1), 229-240

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See detailHow inclusive is inclusive recycling? Recyclers’ perspectives on a cross-sector partnership in Santiago de Chile
Giovannini, Michela; Huybrechts, Benjamin ULiege

in Local Environment (2017)

Inclusive recycling is the inspiring slogan of a project relying on a cross- sector (public–private–civil society) partnership implemented in Latin America with the objective to improve the socioeconomic ... [more ▼]

Inclusive recycling is the inspiring slogan of a project relying on a cross- sector (public–private–civil society) partnership implemented in Latin America with the objective to improve the socioeconomic conditions of recyclers. Through a qualitative study in Santiago de Chile, this paper seeks to understand how inclusive inclusive recycling is, by assessing how organised recyclers perceive the goals, the process, and the outcomes of this project. The main findings converge in observing a general low inclusion of recyclers, but they also enable to decompose the notion of inclusion into three dimensions: “inclusive goals” refers to the extent to which the goals of the recyclers are taken into account when designing the collaboration project; “inclusive process” refers to the extent to which recyclers are involved in the process of implementing the project; and “inclusive outcomes” refers to the capacity of the partnership to acknowledge the achievements of recyclers organisations before (and during) the project and to take into account the ongoing local dynamics when evaluating the project. These findings contribute to better understand the position and challenges of recyclers in this type of partnership and more generally to shed light on the potential power imbalance in waste management cross-sector partnerships. [less ▲]

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See detailGenomewide association of piglet responses to infection with one of two porcine reproductive and respiratory syndrome virus isolates.
Waide, E. H.; Tuggle, C. K.; Serao, N. V. L. et al

in Journal of Animal Science (2017), 95(1), 16-38

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease in the swine industry. Identification of host genetic factors that enable selection for improved performance during PRRS virus ... [more ▼]

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease in the swine industry. Identification of host genetic factors that enable selection for improved performance during PRRS virus (PRRSV) infection would reduce the impact of this disease on animal welfare and production efficiency. We conducted genomewide association study (GWAS) analyses of data from 13 trials of approximately 200 commercial crossbred nursery-age piglets that were experimentally infected with 1 of 2 type 2 isolates of PRRSV (NVSL 97-7985 [NVSL] and KS2006-72109 [KS06]). Phenotypes analyzed were viral load (VL) in blood during the first 21 d after infection (dpi) and weight gain (WG) from 0 to 42 dpi. We accounted for the previously identified QTL in the region on SSC4 in our models to increase power to identify additional regions. Many regions identified by single-SNP analyses were not identified using Bayes-B, but both analyses identified the same regions on SSC3 and SSC5 to be associated with VL in the KS06 trials and on SSC6 in the NVSL trials ( < 5 x 10); for WG, regions on SSC5 and SSC17 were associated in the NVSL trials ( < 3 x 10). No regions were identified with either method for WG in the KS06 trials. Except for the region on SSC4, which was associated with VL for both isolates (but only with WG for NVSL), identified regions did not overlap between the 2 PRRSV isolate data sets, despite high estimates of the genetic correlation between isolates for traits based on these data. We also identified genomic regions whose associations with VL or WG interacted with either PRRSV isolate or with genotype at the SSC4 QTL. Gene ontology (GO) annotation terms for genes located near moderately associated SNP ( < 0.003) were enriched for multiple immunologically (VL) and metabolism- (WG) related GO terms. The biological relevance of these regions suggests that, although it may increase the number of false positives, the use of single-SNP analyses and a relaxed threshold also increased the identification of true positives. In conclusion, although only the SSC4 QTL was associated with response to both PRRSV isolates, genes near associated SNP were enriched for the same GO terms across PRRSV isolates, suggesting that host responses to these 2 isolates are affected by the actions of many genes that function together in similar biological processes. [less ▲]

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See detailLes nouveautés portées par la loi du 17 juin 2016 relative aux marchés publics, en particulier dans les secteurs spéciaux
Cariat, Nicolas; Vrancken, Martin ULiege

in Revue du Droit des Industries de Réseau (2017), 1

La contribution offre un bref compte-rendu du nouveau régime mis en place par la loi du 17 juin 2016 relative aux marchés publics, transposant les directives 2014/24 et 2014/25, singulièrement dans les ... [more ▼]

La contribution offre un bref compte-rendu du nouveau régime mis en place par la loi du 17 juin 2016 relative aux marchés publics, transposant les directives 2014/24 et 2014/25, singulièrement dans les secteurs spéciaux. [less ▲]

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See detailINPP5E Preserves Genomic Stability through Regulation of Mitosis
Sierra Potchanant, EA; Cerabona, D; Sater, ZA et al

in Molecular and Cellular Biology (2017), 37(6), 500-516

The partially understood phosphoinositide signaling cascade regulates multiple aspects of cellular metabolism. Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is ... [more ▼]

The partially understood phosphoinositide signaling cascade regulates multiple aspects of cellular metabolism. Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in the developmental disorders Joubert and MORM syndromes, is essential for the function of the primary cilium and maintenance of phosphoinositide balance in nondividing cells. Here, we report that INPP5E further contributes to cellular homeostasis by regulating cell division. We found that silencing or genetic knockout of INPP5E in human and murine cells impairs the spindle assembly checkpoint, centrosome and spindle function, and maintenance of chromosomal integrity. Consistent with a cell cycle regulatory role, we found that INPP5E expression is cell cycle dependent, peaking at mitotic entry. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit. Our findings identify the previously unknown, essential role of INPP5E in mitosis and prevention of aneuploidy, providing a new perspective on the function of this phosphoinositide phosphatase in health and development. [less ▲]

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See detailPhase-change materials and rigidity
Piarristeguy, A.; Pradel, A.; Raty, Jean-Yves ULiege

in MRS Bulletin (2017), 42(1), 45-49

Rigidity theory is an extraordinary tool to understand glasses. This article demonstrates how this model can help in understanding the link between structure, dynamics, and subtler properties such as ... [more ▼]

Rigidity theory is an extraordinary tool to understand glasses. This article demonstrates how this model can help in understanding the link between structure, dynamics, and subtler properties such as drift and aging, in particular, in phase-change materials (PCMs). First, a map of flexible/rigid regions in the Ge-(Sb)-Te system is drawn on the basis of atomistic structures modeled either by ab initio or reverse Monte Carlo techniques. A clear link between the flexible/rigid nature of the glass and its aging behavior is shown through resistivity drift as a function of composition measurements in amorphous GexTe100-x. In the particular case of amorphous GeTe, application of rigidity theory indicates that the average number of mechanical constraints decreases during aging, making the glass less stressed-rigid. Finally, the stability of PCMs also depends on the topology of the materials. The increasing number of constraints in GeTe when doped with C or N results in increased stability of the PCM. © 2017 Materials Research Society. [less ▲]

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See detailFluvial archives, a valuable record of vertical crustal deformation
Demoulin, Alain ULiege; Mather, Anne; Whittaker, Alexander

in Quaternary Science Reviews (2017)

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature ... [more ▼]

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature of crustal deformation and its history. In recent decades, geomorphic analysis of rivers has proved powerful in elucidating the tectonic evolution of actively uplifting and eroding orogens. Here, we review the main recent developments that have improved and expanded qualitative and quantitative information about vertical tectonic motions (the effects of horizontal deformation are not addressed). Channel long profiles have received considerable attention in the literature, and we briefly introduce basic aspects of the behaviour of bedrock rivers from field and numerical modelling perspectives, before describing the various metrics that have been proposed to identify the information on crustal deformation contained within their steady-state characteristics. Then, we review the literature dealing with the transient response of rivers to tectonic perturbation, through the production of knickpoints propagating through the drainage network. Inverse modelling of river profiles for uplift in time and space is also shown to be very effective in reconstructing regional tectonic histories. Finally, we present a synthetic morphometric approach for deducing the tectonic record of fluvial landscapes. As well as the erosional imprint of tectonic forcing, sedimentary deposits, such as fluvial terrace staircases, are also considered as a classical component of tectonic geomorphology. We show that these studies have recently benefited from rapid advances in dating techniques, allowing more reliable reconstruction of incision histories and estimation of incision rates. The combination of progress in the understanding of transient river profiles and larger, more rigorous data sets of terrace ages has led to improved understanding of river erosion and the implications for terrace profile correlation, i.e., extrapolation of local data to entire profiles. Finally, planform changes in fluvial systems are considered at the channel scale in alluvial rivers and regional level in terms of drainage reorganisation. Examples are given of how numerical modelling can efficiently combine with topographic data to shed new light on the (dis)equilibrium state of drainage systems across regional drainage divides. [less ▲]

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See detailLegal Mobilization Within the Bureaucracy: Disability Rights and the Implementation of Antidiscrimination Law in Sweden
Lejeune, Aude ULiege

in Law and Policy (2017)

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social ... [more ▼]

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social movements' demands or is a field of contention for those demands. Focusing on how disability bureaucrats and activists mobilize antidiscrimination law in Sweden, this article shows that two main factors shape legal mobilization within the bureaucracy and alter the state's ability to become a legal mobilization actor: (1) the institutional relationships between social movement organizations and government agencies; and (2) the profiles and careers of bureaucrats and activists. It concludes by suggesting several lines for further research on law and social movements in nonpluralist countries. [less ▲]

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See detailNumerical simulation of a discontinuous gallery lining's behavior, and its interaction with rock
Salehnia, Fatemeh ULiege; Sillen, Xavier; Li, XiangLing et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2017)

Deep excavation in some geological media needs lining of the gallery. This could limit the extent of the so-called excavation damaged zone and the resulting convergence of the material due to tunneling ... [more ▼]

Deep excavation in some geological media needs lining of the gallery. This could limit the extent of the so-called excavation damaged zone and the resulting convergence of the material due to tunneling. Boom clay, the reference potential host rock in Belgium for disposal of high-level radioactive waste, is one of these media for which lining of the gallery walls is essential. A correct simulation of the lining behavior in the course of the excavation process, where the rock comes into contact with the lining, and in the long term, remains a significant challenge in analysis of the whole coupled phenomena of rock in interaction with the lining. This study aims to numerically model the lining behavior. The main objective is to develop a model that could realistically simulate the behavior of a discontinuous lining made of concrete segments. We propose to numerically analyze the response of the blocks in contact with each other and in interaction with rock, with the use of zero-thickness interface elements. To validate the developed model and a proposed approach, a particular analysis compares the obtained results with the available in situ measurements. This study then discusses the deficiency of the simplistic model that considers a continuous lining. In addition, regarding the contact mechanism on the interface between the rock and the lining, the obtained results demonstrate an interesting relation between the contact phenomena and the shear banding within the rock around the gallery. [less ▲]

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See detailProtean proteases: at the cutting edge of lung diseases.
Taggart, Clifford; Mall, Marcus A.; Lalmanach, Gilles et al

in European Respiratory Journal (2017), 49(2),

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and ... [more ▼]

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and it is now evident that proteases are critical pleiotropic actors orchestrating pathophysiological processes. Recent findings evidenced that the net proteolytic activity also relies upon interconnections between different protease and protease inhibitor families in the protease web.In this review, we provide an overview of these novel concepts with a particular focus on pulmonary pathophysiology. We describe the emerging roles of several protease families including cysteine and serine proteases.The complexity of the protease web is exemplified in the light of multidimensional regulation of serine protease activity by matrix metalloproteases through cognate serine protease inhibitor processing. Finally, we will highlight how deregulated protease activity during pulmonary pathogenesis may be exploited for diagnosis/prognosis purposes, and utilised as a therapeutic tool using nanotechnologies.Considering proteases as part of an integrative biology perspective may pave the way for the development of new therapeutic targets to treat pulmonary diseases related to intrinsic protease deregulation. [less ▲]

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See detailArt Nouveau in Liège : From Avant-garde to a new Eclectism
Charlier, Sébastien ULiege

in Coupdefouet (2017), 28

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See detailDiet effects on bumblebee health
Roger, N.; Michez, D.; Wattiez, R. et al

in Journal of Insect Physiology (2017), 96

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as ... [more ▼]

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as the ability of an organism to mount an immune response, either in cellular, humoral or behavioural forms. In insects, immune capacity can be affected by a variety of factors including pesticides, genetic diversity or diet. Here we focus on an important species of domesticated pollinator, Bombus terrestris, and the potential impact of a poor pollen diet (low nutritional content and toxic) on its health. We investigate three responses at both colony and individual levels: behavioural, humoral and cellular. Our results show that poor pollen diets decrease larval and pupal masses and increase larval ejection as well as adult constitutive immunity (i.e., prophenoloxidase assays). The susceptibility of bumblebees to disease and infection might therefore be greater after a nutritive stress. These findings raise the importance of available plant hosts, especially floral plant species providing pollen with suitable nutritive quality (i.e., nutrient pollen content) for bumblebees. © 2016 Elsevier Ltd [less ▲]

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See detailDiagnostics : les nouveautés sur les biomarqueurs de l'arthrose chez le chien
Boulocher, Caroline; Henrotin, Yves ULiege

in Le nouveau praticien vétérinaire canine/féline (2017), 14(65), 58-61

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See detailRationalising vitamin B6 biofortification in crop plants.
Fudge, Jared; Mangel, Nathalie; Gruissem, Wilhelm et al

in Current Opinion in Biotechnology (2017), 44

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are ... [more ▼]

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are established in all kingdoms. Human vitamin B6 dietary insufficiency or genetic defects in B6 vitamer interconversion result in various neurological and inflammatory pathologies with several populations at-risk or marginal for vitamin B6 status. Three (rice, wheat and cassava) of the world's top five staple crops do not meet the recommended dietary allowance for vitamin B6, when consumed as a major proportion of the diet. In addition, controlled enhancement of the appropriate B6 vitamer in crops has the potential to confer stress resistance. Thus, crop biofortification strategies represent an opportunity to reduce the risk of deficiency in populations with limited diet diversity and quality, as well as improving stress tolerance. [less ▲]

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See detailInvited review: Phenotypes to genetically reduce greenhouse gas emissions in dairying
de Haas, Yvette; Pszczola, Marcin; Soyeurt, Hélène ULiege et al

in Journal of Dairy Science (2017), 100(2), 855-870

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See detailIncreased expression of bacterial amoA during an N2O emission peak in an agricultural field
Theodorakopoulos, Nicolas ULiege; Lognoul, Margaux ULiege; Degrune, Florine ULiege et al

in Agriculture, Ecosystems & Environment (2017), 236

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak ... [more ▼]

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak on a maize crop after a natural rainfall. The peak occurred rapidly after the rainfall began. Spatial and temporal variability in N2O emission was observed between chambers. An analysis of N-cycle gene transcript levels revealed an increase in bacterial amoA gene transcripts (but not in archaeal amoA transcripts), correlating strongly with N2O emission. This suggests the involvement of nitrification enzymes, despite a high water-filled pore space (80%). Reverse transcription of bacterial 16S rRNA followed by partial sequencing of the resulting cDNAs revealed few rainfall-induced changes in the potentially active bacterial community, and notably no significant change in the relative abundance of 16S rRNAs from the nitrifier genus Nitrosospira. Expression of the amoA gene appears as a possible proxy for monitoring the N2O emission peak. To our knowledge, this is the first experiment to evaluate the expression of N-cycle genes during an N2O emission peak on an agricultural field. [less ▲]

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See detailThe impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: an EADC study
Bosco, P.; Redolfi, A.; Bocchetta, M. et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2017)

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See detailMicrostructural and functional correlates of glutamate concentration in the posterior cingulate cortex.
Arrubla Martinez, Jorge Andres ULiege; Farrher, Ezequiel; Strippelmann, Johanna et al

in Journal of Neuroscience Research (2017)

Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers ... [more ▼]

Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers in which glutamate levels were measured in the posterior cingulate cortex (PCC) using 1H magnetic resonance spectroscopy at 3T. The advantages of simultaneous electroencephalography and magnetic resonance imaging (EEG-MRI) were exploited and the subjects were measured in the same session and under the same physiological conditions. Diffusion tensor imaging (DTI), functional MRI (fMRI) and EEG were measured in order to investigate the functional and microstructural correlates of glutamate. The concentration of glutamate (institute units) was calculated and those values were tested for correlation with the metrics of resting state fMRI, DTI, and EEG electrical sources. Our results showed that the concentration of glutamate in the PCC had a significant negative correlation with the tissue mean diffusivity in the same area. The analysis of resting state networks did not show any relationship between the concentration of glutamate and the intrinsic activity of the resting state networks. The concentration of glutamate showed a positive correlation with the electrical generators of alpha-1 frequency and a negative correlation with the generators of alpha-2 and beta-1 electrical generators. (c) 2017 Wiley Periodicals, Inc. [less ▲]

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See detailComputed tomography and ultrasound to determine fetal head station.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULiege et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017), 49(2), 279-280

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See detailVulnerability evaluation of millet and sorghum cropping system to climate change and adoption of new technologies in Mali
Sissoko, Penda ULiege; Aune, Jens B.; Senneväg, Gry et al

in Asian Journal of Science and Technology (2017), 8(1), 4176-4182

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi ... [more ▼]

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi-structured interviews (ISS) using questionnaires addressed to the chiefs of family farm (FAE) were used for the collection of data. The descriptive statistics and matrices were realized for the data analysis using the following softwares: EXCEL and SPSS20.The results of the surveys conducted in 2014 among 360 farms in Sahelian and Sudano-Sahelian areas, shows that agricultural producers are aware of the main factors affecting the productivity of their cropping system and food security of agricultural holdings. Rainfall variability, characterized by failure and irregularity of rains is the main constraint of cropping systems based on millet and sorghum as stated by 97% of surveyed producers, followed by soil poverty 81%, and the lack of agricultural equipment 47%. The impacts of these factors at the farms level are translated by a decrease in the crops yields and on the frequency of the shortages in foodstuffs which are observed by 98% of the farms every year and more than 50% every 3 years. To reduce vulnerabilities, practices and innovations were adopted by farms as strategies. The main concern fertilizer micro dosing technics, seed soaking, improved varieties, organic and mineral fertilization, soils and water management technics, mechanical sowing, and agro forestry were adopted as strategies. [less ▲]

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See detailFocus sur les lymphocytes T dans la maladie du greffon contre l'hôte après allogreffe de cellules soucges hématopoïétiques: implications pour de nouvelles stratégies de prévention
Vrancken, L; Delens, Loïc ULiege; BEGUIN, Yves ULiege et al

in Oncol. Hematol. (2017), 11

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches ... [more ▼]

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches hématopoïétiques. Bien que la physiopathologie de celle-ci ne reste que partiellement élucidée à ce jour, il est classiquement admis que les lymphocytes T (LT) jouent un rôle important dans son processus biologique. Les progrès récents de l’immunologie des LT dans la GVHa ont permis de diversifier les pistes visant à prévenir la survenue de cette complication post-greffe. Plusieurs approches sont en cours d’exploration dans des essais cliniques avec des résultats encourageant tels que la manipulation ex vivo des LT avant leur transfert chez le patient afin de leur faire exprimer des gènes suicide, l’élimination in vivo des LT proliférant directement après la greffe, l’inhibition de l’activation des LT en interférant avec les voies de signalisation en aval du TCR ou celles induites par les cytokines, l’induction de l’anergie des LT en bloquant les signaux de costimulation, le blocage de l’adressage des LT vers les organes lymphoïdes secondaires et les tissus cibles, la promotion de l’immunotolérance par la perfusion de lymphocytes T régulateurs ou par l’utilisation d’agents favorisant leur différenciation et leurs fonctions in vivo et la modulation de l’expression génique des cellules immunitaires par des modulateurs épigénétiques. Outre la prévention de la GVHa, le défi des nouvelles stratégies consiste également à ne pas compromettre l’effet bénéfique de la greffe contre la tumeur ni la reconstitution des défenses anti-infectieuses. [less ▲]

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See detailPolyurethane coatings in 20th century outdoor painted sculptures. Part II: Comparative study of four systems by means of Py-GC/MS
Defeyt, Catherine ULiege; Schilling, Michael; Langenbacher, Julia et al

in Heritage Science (2017), 5(15),

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to ... [more ▼]

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to coat sculptures intended for an outdoor setting. However, the PU class includes various systems, such as two package solvent-borne, two package water-borne, one package water-borne and fluoropolymer polyurethanes, which possess very different properties. 115 reference samples of PU coatings were investigated by means of Py-GC/MS, in order to outline the differences and the similarities existing, in terms of composition, between the major PU systems used for creating as well as for conserving modern painted outdoor sculptures. The Py- GC/MS study of an extended number of reference samples showed that the composition of equivalent PU systems strongly varies depending on the product line and the manufacturer. Furthermore the comparison of all the produced pyrograms allowed defining characteristic marker compounds helpful to discriminate specific PU paint systems. [less ▲]

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See detailAntiplasmodial activity of Heinsia crinita (Rubiaceae) and identification of new iridoids.
Tshisekedi Tshibangu, P.; Mutwale Kapepula, P.; Kabongo Kapinga, M. J. et al

in Journal of Ethnopharmacology (2017), 196

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in the Democratic Republic of the Congo (DRC) as a remedy against malaria. Investigations were conducted on crude extracts of leaves, fruits and stem barks in view to validate their use and to determine which plant part possesses the best antiplasmodial properties. MATERIALS AND METHODS: Different plant parts were extracted with methanol, ethanol and dichloromethane. Based on the preliminary assays, the dichloromethane extract of the stem bark was subjected to fractionation using preparative HPLC system and column chromatography. This step led to the isolation of two new iridoids which had their structures elucidated by NMR, UV, MS and FT-IR spectroscopic techniques. Extracts and pure compounds were tested in vitro against the 3D7 strain of Plasmodium falciparum. The inhibition of the parasite growth was evaluated in vitro by colorimetric method (p-LDH assay) and their cytotoxicity evaluated in vitro against the human non-cancer fibroblast cell line (WI38) through WST1 assay. The in vivo antiplasmodial activity was assessed by the inhibition of Plasmodium berghei growth in infected mice treated with the ethanol extract of H. crinita stem bark at the concentrations of 200 and 300mg/Kg/day per os, using a protocol based on the 4-d suppressive test of Peters and compared to a non-treated negative control group of mice (growth =100%). Finally the antioxidant activity of the same extract was evaluated using ABTS, DPPH and cell-based assays. RESULTS: A moderate in vitro antiplasmodial activity was observed for the dichloromethane extract of the stem bark of H. crinita (IC50 =29.2+/-1.39microg/mL) and for the two new iridoids, lamalbide 6, 7, 8- triacetate (IC50 =16.39+/-0.43microg/mL) as well as for its aglycone lamiridosin 6, 7, 8-triacetate (IC50 =0.44.56+/-1.12microg/mL). The ethanolic stem bark extract (200 and 300mg/kg/day, oral route) showed a moderate in vivo antimalarial activity in Plasmodium berghei-infected mice with 27.84+/-2.75% and 48.54+/-3.76% of inhibition of the parasite growth, respectively (p<0.01).). This extract displayed high cellular antioxidant activity using dichlorofluorescein-diacetate (DCFDA) on HL-60 monocytes. These crude extracts and pure compounds tested at the higher concentration of 100microg/mL did not show any cytotoxicity against WI38 cells. CONCLUSIONS: The results showed that H. crinita extracts possess antimalarial activity and contain some unusual iridoids with moderate antiplasmodial activity, therefore justifying to some extent its traditional use by the local population in DRC for this purpose. This is the first report of the isolation and antiplasmodial activity of these two new iridoids. [less ▲]

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See detailObjective assessment of visual pursuit in patients with disorders of consciousness: an exploratory study.
Wannez, Sarah ULiege; Hoyoux, Thomas; Langohr, Thomas et al

in Journal of Neurology (2017)

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See detailHeterogeneous incidence and propagation of spreading depolarizations.
Kaufmann, Dan; Theriot, Jeremy; Zyuzin, Jekaterina et al

in Journal of Cerebral Blood Flow & Metabolism (2017)

Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically ... [more ▼]

Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically, apparently not respecting the anatomic, synaptic, functional, or vascular architecture of the brain. However, there is evidence that spreading depolar- izations are not truly concentric, isotropic, or homogeneous, either in space or in time. Here we present evidence from KCl-induced spreading depolarizations, in mouse and rat, in vivo and in vitro, showing the great variability that these depolarizations can exhibit. This variability can help inform the mechanistic understanding of spreading depolarizations, and it has implications for their phenomenology in neurologic disease. [less ▲]

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See detailTransdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.
Sergeant, Camille; Jublanc, Christel; Leclercq, Delphine et al

in American Journal of Surgical Pathology (2017)

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a ... [more ▼]

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed. [less ▲]

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See detailScreening for the metabolic syndrome in subjects with migraine
Streel, Sylvie ULiege; Donneau, Anne-Françoise ULiege; Dardenne, Nadia ULiege et al

in Cephalalgia : An International Journal of Headache (2017)

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See detailTargeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases.
Garcia-Caballero, Melissa; Paupert, Jenny; Blacher, Silvia ULiege et al

in Journal of Hematology & Oncology (2017), 10(1), 122

BACKGROUND: Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic ... [more ▼]

BACKGROUND: Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic vessels (lymphangiogenesis) in primary tumors facilitates tumor cell dissemination to regional lymph nodes and correlates with distant metastases. Lymphangiogenesis has thus emerged as a suitable therapeutic target to block metastases, but no anti-lymphangiogenic compounds have been approved for clinical use to date. Therefore, new or improved therapies blocking lymphatic metastases are urgently required. METHODS: We established murine breast tumors to assess the effect of AD0157 on tumor growth, lymphangiogenesis, and lymphatic dissemination. Then, a battery of in vivo (mouse corneal neovascularization and ear sponges), ex vivo (mouse lymphatic rings and rat mesentery explants), and in vitro (proliferation, tubulogenesis, wound-healing, Boyden chambers, and spheroids) assays was used to give insight into the lymphangiogenic steps affected by AD0157. Finally, we investigated the molecular pathways controlled by this drug. RESULTS: AD0157 was found to inhibit the growth of human breast cancer xenografts in mice, to strongly reduce tumor-associated lymphangiogenesis and to block metastatic dissemination to both lymph nodes and distant organs. The high anti-lymphangiogenic potency of AD0157 was further supported by its inhibitory activity at low micromolar range in two in vivo pathological models and in two ex vivo assays. In addition, AD0157 inhibited lymphatic endothelial cell proliferation, migration and invasion, cellular sprouting, and tube formation. Mechanistically, this compound induced apoptosis in lymphatic endothelial cells and decreased VEGFR-3/-2, ERK1/2, and Akt phosphorylations. CONCLUSIONS: These findings demonstrate the suitability of AD0157 to suppress tumor-associated lymphangiogenesis. Beyond discovering a new potent anti-lymphangiogenic drug that is worth considering in future clinical settings, our study supports the interest of designing anti-lymphangiogenic therapies to avoid distant metastatic processes. [less ▲]

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See detailSimultaneous analysis of nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry.
Huang, Yang; Zhang, Tingting; Zhao, Yumei et al

in Journal of Pharmaceutical & Biomedical Analysis (2017)

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ... [more ▼]

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ginseng extracts. Few analytical methods have been developed so far to simultaneously analyze these three classes of compounds with different polarities present in ginseng extracts. In the present study, a simple and efficient analytical method was successfully developed for the simultaneous separation of 17 nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry (SFC-MS). The effect of various experimental factors on the separation performance, such as the column type, temperature and backpressure, the type of modifier and additive, and the concentration of make-up solvent were systematically investigated. Under the selected conditions, the developed method was successfully applied to the quality evaluation of 14 batches of ginseng extracts from different origins. The results obtained for the different batches indicate that this method could be employed for the quality assessment of ginseng extracts. [less ▲]

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See detailPostembryonic development of appendicular and axial skeletons in Labeo parvus (Cyprinidae)
Lederoun, Djiman; Montchowui, Elie; Lalèyè, Philippe et al

in Cybium (2017), 41(1), 3-10

The axial and appendicular skeletons in Labeo parvus (Cyprinidae) were investigated from hatching to 29 days post-hatch (dph) in cleared and stained specimens. The cartilaginous axial caudal skeleton of L ... [more ▼]

The axial and appendicular skeletons in Labeo parvus (Cyprinidae) were investigated from hatching to 29 days post-hatch (dph) in cleared and stained specimens. The cartilaginous axial caudal skeleton of L. parvus develops like in other cyprinids. The first cartilaginous elements, namely hypurals I and II, appeared 6 dph before notochord flexion. Ossification of the complex begins with that of caudal rays on day 10, next the vertebral bodies, and then all the hypurals on day 14. Dorsal fin development is quite comparable to that of the anal fin. Cartilaginous structures (proximal and distal pterygiophores) appear on day 14 in both fins. Ossification of both fins starts with the rays on day 14, then with the anterior pterygiophores on day 19. Examination of the axial skeleton shows that cartilaginous structures, namely basidorsals and basiventrals, arise on day 14 while ossification begins with the anterior vertebral structures on day 10. [less ▲]

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See detailAltered functional brain connectivity in patients with visually induced dizziness
Van Ombergen, Angelique; Heine, Lizette ULiege; Jillings, Steven et al

in NeuroImage (2017), 14

Background: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience ... [more ▼]

Background: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience dizziness, discomfort, disorientation and postural unsteadiness. The underlying pathophysiology of VID is still poorly understood. Objective: The aimof the current explorative study was to gain a first insight in the underlying neural aspects of VID. Methods:We included 10 VID patients and 10 healthymatched controls, all ofwhich underwent a resting state fMRI scan session. Changes in functional connectivitywere explored bymeans of the intrinsic connectivity contrast (ICC). Seed-based analysis was subsequently performed in visual and vestibular seeds. Results: We found a decreased functional connectivity in the right central operculum (superior temporal gyrus), as well as increased functional connectivity in the occipital pole in VID patients as compared to controls in a hypothesis-free analysis. A weaker functional connectivity between the thalamus and most of the right putamen was measured in VID patients in comparison to controls in a seed-based analysis. Furthermore, also by means of a seed-based analysis, a decreased functional connectivity between the visual associative area and the left parahippocampal gyrus was found in VID patients. Additionally,we found increased functional connectivity between thalamus and occipital and cerebellar areas in the VID patients, as well as between the associative visual cortex and both middle frontal gyrus and precuneus. Conclusions:We found alterations in the visual and vestibular cortical network in VID patients that could underlie the typical VID symptoms such as a worsening of their vestibular symptoms when being exposed to challenging visual stimuli. These preliminary findings provide the first insights into the underlying functional brain connectivity in VID patients. Future studies should extend these findings by employing larger sample sizes, by investigating specific task-based paradigms in these patients and by exploring the implications for treatment. [less ▲]

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See detailA Weak Local Irregularity Property in Sν Spaces
Clausel, Marianne; Nicolay, Samuel ULiege

in Mediterranean Journal of Mathematics (2017), 14(3), 102

It has been shown that, from the prevalence point of view, elements of the Sν spaces are almost surely multifractal, while the Hölder exponent at almost every point is almost surely equal to the maximum ... [more ▼]

It has been shown that, from the prevalence point of view, elements of the Sν spaces are almost surely multifractal, while the Hölder exponent at almost every point is almost surely equal to the maximum Hölder exponent. We show here that typical elements of Sν are very irregular by proving that they almost surely satisfy a weak irregularity property: there exists a local irregularity exponent which is constant for almost every element of Sν and equal to the lowest Hölder exponent. [less ▲]

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See detailFirst report of the bee louse Braula schmitzi (Diptera: Braulidae) in apiaries of the “Los Chillos” Valley, Province of Pichincha, Ecuador
Zapata-Carvajal, N; Cherrez-Neacato, A; Martin-Solano, S et al

in Journal of Apicultural Research (2017)

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See detailOrganic Farming and Small-Scale Farmers: Main Opportunities and Challenges
Jouzi, Zeynab; Azadi, Hossein ULiege; Taheri, Fatemeh et al

in Ecological Economics (2017), 132(February 2017), 144-154

Producing enough food to meet the needs of a growing population has always been the greatest concern of food policy-makers around the world. Given the increasing attention to organic farming (OF), we ... [more ▼]

Producing enough food to meet the needs of a growing population has always been the greatest concern of food policy-makers around the world. Given the increasing attention to organic farming (OF), we conducted this study to investigate the main opportunities and challenges of the food production system of small-scale farmers in developing countries with an emphasis on their livelihoods. The study showed that the most significant advantages of OF are environmental protection and a higher resilience to environmental changes, increasing farmers' income and reducing external input cost, enhancing social capacity and increasing employment opportunities. A s well as enhancing food security primarily by increasing the food purchasing power of local people. However, the main challenges of this food production system include lower yields in comparison to conventional systems, difficulties with soil nutrient management, certification and market barriers, and the educational and research needs of small-holders. The paper concludes that even though OF might present some significant challenges to small-scale farmers, it could/should still be considered as a part of the solution and means of improving their livelihoods. [less ▲]

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See detailEpithelial-Mesenchymal Plasticity and Circulating Tumor Cells: Travel Companions to Metastases
Francart, Marie-Emilie ULiege; Lambert, Justine ULiege; Vanwynsberghe, Aline ULiege et al

in Developmental Dynamics : An Official Publication of the American Association of Anatomists (2017)

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See detailL'ethnicité et ses frontières. Deuxième édition revue et mise à jour.
Martiniello, Marco ULiege

in Ethnic and Racial Studies (2017)

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See detailThe CXCL12/CXCR4 pathway or the autocrine proliferative loop of the glioblastoma stem cells
Rogister, Bernard ULiege

in Translational Cancer Research (2017), 6(Suppl 2), 388-390

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See detailHigh resolution (1 km) positive degree-day modelling of Greenland ice sheet surface mass balance, 1870–2012 using reanalysis data
Wilton, D.; Jowett, A.; Hanna, E. et al

in Journal of Glaciology (2017), 63

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature ... [more ▼]

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature parameterization as compared with a previous version and is run at 1 km rather than 5 km resolution. The improvements lead overall to higher SMB with the same forcing data. We also compare our model with results from two regional climate models (RCMs). While there is good qualitative agreement between our PDD model and the RCMs, it usually results in lower precipitation and lower runoff but approximately equivalent SMB: mean 1979–2012 SMB (± standard deviation), in Gt a−1, is 382 ± 78 in the PDD model, compared with 379 ± 101 and 425 ± 90 for the RCMs. Comparison with in situ SMB observations suggests that the RCMs may be more accurate than PDD at local level, in some areas, although the latter generally compares well. Dividing the GrIS into seven drainage basins we show that SMB has decreased sharply in all regions since 2000. Finally we show correlation between runoff close to two calving glaciers and either calving front retreat or calving flux, this being most noticeable from the mid-1990s. [less ▲]

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See detailResponsible research and innovation as a travesty of technology assessment?
Delvenne, Pierre ULiege

in Journal of Responsible Innovation (2017)

The relation between technology assessment (TA) and responsible research and innovation (RRI) is a very topical (and controversial) issue, as TA is clearly enveloped in broader science, technology and ... [more ▼]

The relation between technology assessment (TA) and responsible research and innovation (RRI) is a very topical (and controversial) issue, as TA is clearly enveloped in broader science, technology and innovation (STI) processes, such as the EU-wide shift towards RRI. In this short response to van Lente et al.’s [Van Lente, Harro, Tsjalling Swierstra, and Pierre-Benoit̂ Joly. 2017. “Responsible Innovation as a Critique of Technology Assessment.” Journal of Responsible Innovation] essay, I first stress that this contribution has several merits; for example, it points to pervasive challenges for TA communities, such as the issue of including normative concerns when assessing innovations, it opens these challenges to debate, without shying away from engaging TA communities. However, I disagree with the authors’ claim that RRI would be ‘a next step of TA’ or even a ‘form of TA’. In my essay, I explain why I believe RRI is different from TA and why, rather than a critique of TA, RRI could instead lead to a travesty of TA, threatening the vitality and the uniqueness of TA institutions in the long-term. Under the spell of RRI, TA risks being reduced to a role of mere provider of ex-ante impact assessments. I conclude that following the money attached to RRI has a price that TA institutions should carefully, critically and reflexively consider before they pay. [less ▲]

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See detailMultiple myeloma bone disease: from mechanisms to next generation therapy
Heusschen, Roy ULiege; Muller, Joséphine ULiege; WITHOFS, Nadia ULiege et al

in Belgian Journal of Hematology (2017), 8

Multiple myeloma bone disease is a major cause of morbidity and mortality in multiple myeloma patients and persists even in patients in remission. Multiple myeloma bone disease is caused by an uncoupling ... [more ▼]

Multiple myeloma bone disease is a major cause of morbidity and mortality in multiple myeloma patients and persists even in patients in remission. Multiple myeloma bone disease is caused by an uncoupling of bone remodelling, with increased osteoclast activity and decreased osteoblast activity, culminating in lytic bone destruction. Bisphosphonates are the current standard-of-care but new therapies are needed. As the molecular mechanisms controlling multiple myeloma bone disease are increasingly understood, new therapeutic targets are extensively explored in the preclinical setting and initial clinical trials with novel compounds show promising results. In this review, we provide a comprehensive overview of the biology of multiple myeloma bone disease, summarise its current clinical management and discuss preclinical and clinical data on next generation therapies. [less ▲]

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See detailFifth European Dirofilaria and Angiostrongylus Days (FiEDAD) 2016
Simón, F.; Kartashev, V.; González-Miguel, J. et al

in Parasites & Vectors (2017), 10(1), 5

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See detailInfrared observations of Jovian aurora from Juno's first orbits: Main oval and satellite footprints
Mura, A.; Adriani, A.; Altieri, F. et al

in Geophysical Research Letters (2017), 44(11), 5308-5316

The Jovian Infrared Auroral Mapper (JIRAM) is an imager/spectrometer on board NASA/Juno mission for the study of the Jovian aurorae. The first results of JIRAM's imager channel observations of the H3 ... [more ▼]

The Jovian Infrared Auroral Mapper (JIRAM) is an imager/spectrometer on board NASA/Juno mission for the study of the Jovian aurorae. The first results of JIRAM's imager channel observations of the H3 + infrared emission, collected around the first Juno perijove, provide excellent spatial and temporal distribution of the Jovian aurorae, and show the morphology of the main ovals, the polar regions, and the footprints of Io, Europa and Ganymede. The extended Io “tail” persists for ~3 h after the passage of the satellite flux tube. Multi-arc structures of varied spatial extent appear in both main auroral ovals. Inside the main ovals, intense, localized emissions are observed. In the southern aurora, an evident circular region of strong depletion of H3 + emissions is partially surrounded by an intense emission arc. The southern aurora is brighter than the north one in these observations. Similar, probably conjugate emission patterns are distinguishable in both polar regions. ©2017. American Geophysical Union. All Rights Reserved. [less ▲]

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See detailChitosan : a promising polymer for cartilage repair and viscosupplementation
Comblain, Fanny ULiege; Rocasalbas, Guillem; Gautier, Sandrine et al

in Bio-medical Materials & Engineering (2017)

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See detailA distinctive marginal marine palynological assemblage from the Pridoli of Northwestern Saudi Arabia
Breuer, P.; Le Hérissé, A.; Paris, F. et al

in Revue de Micropaléontologie (2017), 60

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See detailChemical composition of essential oils and hydrosols of three Eucalyptus species from Senegal: Eucalyptus alba Renv, Eucalyptus camaldulensis Dehnh and Eucalyptus tereticornis Hook
Barka Ndiaye, El Hadji; Talla Gueye, Momar; Ndiaye, Ibrahima et al

in American Journal of Essential Oils and Natural Products (2017), 5(1), 1-7

The leaves of three eucalyptus species Eucalyptus Alba, Eucalyptus camaldulensis and ucalyptus tereticornis were collected in Kaolack (Senegal) and were extracted by steam distillation after 3, 7, 14 and ... [more ▼]

The leaves of three eucalyptus species Eucalyptus Alba, Eucalyptus camaldulensis and ucalyptus tereticornis were collected in Kaolack (Senegal) and were extracted by steam distillation after 3, 7, 14 and 21 days of drying. The volatile components of aqueous distillates (hydrosols) were obtained by liquid–liquid extraction using n-hexane. The different extracts were analyzed by gas chromatography coupled to a flame ionization detector (GC-FID) and by gas chromatography coupled to a mass spectrometer (GC-MS). Essential oils yields obtained range from 0.3 to 1.6%. E. camaldulensis had the higher yield. Forty four compounds were characterized in E. camaldulensis essential oils. These lasts were dominated by 1.8-cineole (47.54 to 52.47%), limonene (16.5 to 19.1%), α-pinene (7.3 to 11.2%) and p-cymene (6.0 to 8.8%). Fifty compounds were identified in E. Alba oils with 1.8-cineole (36.0-38.3%) α-pinene (19.0-26.4%), limonene (5.7- 8.3%), trans-pinocarveol (3.5 -5.0%) β-pinene (1.9 to 4.6%) as major compounds. In E. tereticornis oils, fifty two compounds were identified. Their composition were dominated by p-cymene (42.49 to 48.51%) followed by 1.8-cineole (21.3- 24.5%), limonene (4.8- 5.9%) and α-pinene (1.9 to 6.7%). The analyzed hydrosols were composed by oxygenated molecules whose major part was found in oils. As essential oils, all corresponding hydrosols hade high rate of 1.8-cineole. E. alba hydrosol contains mainly 1.8-cineole (39.1%), trans-pinocarveol (19.3%), pinocarvone (6.8%). E. camaldulensis hydrosol was dominated by 1.8-cineole (52.6%), α-terpineol (6.6%), cis-p-mentha-1-(7)-8-dien-2ol (5.1%). The major compounds of E. tereticornis hydrolat were: 1.8-cineole (30.7%), α-terpineol (8.8%), trans-pinocarveol (7.6%), carvacrol (7.0%). The results showed that although 1.8-cineole was the main component of the hydrosols of all eucalyptus species, but its relative content was higher in E. camaldulensis. [less ▲]

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See detailFrom skeletal muscle to stem cells: an innovative and minimally-invasive process for multiple species
Ceusters, Justine ULiege; Lejeune, Jean-Philippe ULiege; Sandersen, Charlotte ULiege et al

in Scientific Reports (2017), 7(696),

Bone marrow and adipose tissue represent the two most commonly exploited sources of adult mesenchymal stem cells for musculoskeletal applications. Unfortunately the sampling of bone marrow and fat tissue ... [more ▼]

Bone marrow and adipose tissue represent the two most commonly exploited sources of adult mesenchymal stem cells for musculoskeletal applications. Unfortunately the sampling of bone marrow and fat tissue is invasive and does not always lead to a sufficient number of cells. The present study describes a novel sampling method based on microbiopsy of skeletal muscle in man, pigs, dogs and horses. The process includes explant of the sample, Percoll density gradient for isolation and subsequent culture of the cells. We further characterized the cells and identified their clonogenic and immunomodulatory capacities, their immune-phenotyping behavior and their capability to differentiate into chondroblasts, osteoblasts and adipocytes. In conclusion, this report describes a novel and easy-to-use technique of skeletal muscle-derived mesenchymal stem cell harvest, culture, characterization. This technique is transposable to a multitude of different animal species. [less ▲]

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See detailNine facultative endosymbionts in aphids. A review
Guo, Jianqing ULiege; Hatt, Séverin ULiege; He, Kanglai et al

in Journal of Asia-Pacific Entomology (2017), 20

Aphids are frequently engaged in mutualistic associations with endosymbionts. Symbionts are bacterial or fungal microorganisms that can be obligate or facultative to aphids. Research showed facultative ... [more ▼]

Aphids are frequently engaged in mutualistic associations with endosymbionts. Symbionts are bacterial or fungal microorganisms that can be obligate or facultative to aphids. Research showed facultative (or secondary) symbionts have numerous effects on their host aphids such as resistance to heat shock, parasitoids and fungus etc., which may consequently promote a co-evolution between symbionts and hosts. However, this symbiotic relation may be affected by several factors, such as the ability of symbionts to spread from aphids to others within and across populations, and the cost of infections for hosts. Moreover, aphid-symbionts interactions may be affected by aphid living environment such as its host plant, the presence of natural enemies or the temperature. Here we firstly described the functions of nine facultative symbionts (Serratia symbiotica, Hamiltonella defensa, Regiella insecticola, Rickettsia, Rickettsiella, PAXS (pea aphid X-type symbiont), Spiroplasma, Wolbachia and Arsenophonus) studied in aphids one by one, and discussed the associations between these symbionts and aphids, plants and environment. We aim to have a better knowledge of the roles the facultative symbionts play in aphid biology, ecology and evolution, which we believe can provide new inspirations for aphid control. [less ▲]

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See detailRisks for All-Cause Mortality: Stratified by Age, Estimated Glomerular Filtration Rate and Albuminuria.
Warnock, DG; DELANAYE, Pierre ULiege; Glassock, RJ

in Nephron (2017), 136(4), 292-297

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See detailPeur de l'intimité dans la relation amoureuse adolescente : L'implication de l'attachement parental et de l'attachement romantique
Courtain, Audrey ULiege; Glowacz, Fabienne ULiege

in Annales Médico-Psychologiques (2017), 175(4),

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment ... [more ▼]

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment and the internal working models related to it, while being colored by the emerging romantic attachment and its brand new internal working models. Attachments are deeply shaped by a dynamic interaction whereby the self tries to figure out how to reach security and autonomy still taking the other into account. This considered, intimacy also implies a dynamic feature: on the one hand, closeness and sharing of feelings and/or experiences, and on the other hand, individuality and maintaining of one’s ego. However, just like attachments may be insecure, a fear of intimacy cannot be underestimated during dating. Eventually, bearing in mind the societal and cultural components of attachment and intimacy, gendered explanations cannot be ignored, especially during adolescence. Objectives: Three hypotheses are being tested. First, the continuity from parental to romantic attachment is postulated, meaning that a secure, preoccupied or dismissing attachment to parents might lead to a subsequent secure, preoccupied or dismissing attachment to romantic partners. Second, the influence of parental attachment on the fear of intimacy during teen dating is questioned. The difficult dynamic of closeness/individuality might be explained by the parental attachment’s patterns. Third, the impact of romantic attachment on the fear of intimacy during teen dating is assessed. Also, dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship are studied and put in perspective with the romantic attachment. Materials and methods: The initial sample is made of 283 Belgian students (61% girls) from different teaching systems, aged of 16-22 years old (mean age : 17.43), and 232 of them had already had a dating experience by this time. They were questioned about dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship. Two questionnaires were also self-administered: the Behavioral Systems Questionnaire (assessing attachment) and the Fear of Intimacy Scale. Statistical analyses such as Pearson Chi², Anova and Post-Hoc LSD were carried out. Results: First, we cannot see any continuity between parental and romantic attachment. Second, dismissing attachment to parents fosters the fear on intimacy, compared to secure profiles; this is especially true for dismissing girls. Third, dismissing and preoccupied attachments to romantic partners foster the fear of intimacy, compared to secure profiles; this is especially true for dismissing and even more for preoccupied boys. Also, preoccupied attachment to romantic partners fosters the multiplication of datings, compared to secure; this is especially true for preoccupied and even more for dismissing girls. Finally, there is no effect of romantic attachment on the age of the first dating experience or on the longest lasting relationship. Conclusion: Parental and romantic attachments are involved in the fear of intimacy experienced by adolescents during dating. Still, attachment styles’ influence seems different for girls and boys, and highlights the need to distinguish girls’ from boys’ teen dating experiences. [less ▲]

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See detailFactors controlling spatial and temporal patterns of multiple pesticide compounds in groundwater (Hesbaye chalk aquifer, Belgium)
Hakoun, Vivien; Orban, Philippe ULiege; Dassargues, Alain ULiege et al

in Environmental Pollution (2017)

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To ... [more ▼]

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To uncover which factors govern pesticide compound concentrations in a chalk aquifer, we develop a methodology based on time series analyses, uni- and multivariate statistics accounting for concentrations below detection limits. The methodology is applied to long records (1996–2013) of a restricted compound (bentazone), three banned compounds (atrazine, diuron and simazine) and two metabolites (deethylatrazine (DEA) and 2,6–dichlorobenzamide (BAM)) sampled in the Hesbaye chalk aquifer in Belgium. In the confined area, all compounds had non-detects fractions >80%. By contrast, maximum concentrations exceeded EU’s drinking-water standard (100 ngL-1) in the unconfined area. This contrast confirms that recent recharge and polluted water did not reach the confined area, yet. Multivariate analyses based on variables representative of the hydrogeological setting revealed higher diuron and simazine concentrations in the southeast of the unconfined area, where urban activities dominate land use and where the aquifer lacks protection from a less permeable layer of hardened chalk. At individual sites, positive correlations (up to τ =0,48 for bentazone) between pesticide compound concentrations and multi-annual groundwater level fluctuations confirm occurrences of remobilization. A downward temporal trend of atrazine concentrations likely reflects decreasing use of this compound over the last 28 years. However, the lack of a break in concentrations time series and maximum concentrations of atrazine, simazine, DEA and BAM exceeding EU’s standard post-ban years provide evidence of persistence. Contrasting upward trends in bentazone concentrations show that a time lag is required for restriction measures to be efficient. These results shed light on factors governing pesticide compound concentrations in chalk aquifers. The developed methodology is not restricted to chalk aquifers, it could be transposed to study other pollutants with concentrations below detection limits. Several factors govern pesticide compounds concentrations in the chalk: hydrogeological setting, land use, groundwater level fluctuations and persistence. [less ▲]

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See detailPerformance-Based Financing in the heath sector in low- and middle-income countries: Is there anything whereof it may be said, See, this is new?
Paul, Elisabeth ULiege; Renmans, Dimitri

in International Journal of Health Planning and Management (2017)

Whereas performance‐based financing (PBF) is nowdeveloping fast in the health sector in low‐ and middle‐income countries and is presented an innovative approach—concomitantly, subject to a separate ... [more ▼]

Whereas performance‐based financing (PBF) is nowdeveloping fast in the health sector in low‐ and middle‐income countries and is presented an innovative approach—concomitantly, subject to a separate research stream—it sharesmany features of the “managing for results” (MfR) and performance‐based budgeting (PBB) currents that have existed for decades. In this paper, we first argue that PBF as currently developed in the health sector in low‐ and middle‐income countries shares many features and thus can be viewed as an avatar of MfR andmore precisely PBB. Secondly,we drawlessons fromthe literature on MfR and PBB so as to (1) better apprehend PBF conceptually and (2) avoid pitfalls and better design PBF schemes in practice. We argue that the lessons from the theoretical and empirical literature on MfR and PBB offer interesting insights to feed into a “theory of change” of PBF, enabling to analyse critical aspects and better design PBF schemes. Moreover, it is hoped that just like MfR processes have been demonstrated as having the potential to boost individual performance not only through links with financial incentives but also through acting on other sources of motivation, one can demonstrate more accurately by which mechanisms the various elements of the PBF package can help improve health sector results. [less ▲]

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See detailLe colloque Francarbi à Bruxelles : le principe du contradictoire en arbitrage
Caprasse, Olivier ULiege

in Journal des Tribunaux (2017)

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See detailQue peut la doctrine en droit des sociétés (et ailleurs)?
Thirion, Nicolas ULiege

in Revue Pratique des Sociétés - Tijdschrift voor Rechtspersoon en Vennootschap (2017), 1

A quelle condition la doctrine peut-elle relever d'une démarche proprement scientifique? Telle est la question qu'abord cet éditorial.

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See detailSedation of Patients With Disorders of Consciousness During Neuroimaging: Effects on Resting State Functional Brain Connectivity.
KIRSCH, Murielle ULiege; Guldenmund, Pieter; Bahri, Mohamed Ali ULiege et al

in Anesthesia and Analgesia (2017), 124(2),

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See detailApplication of a 3D unsteady surface panel method with flow separation model to horizontal axis wind turbines
Prasad, Chandra Shekhar; Dimitriadis, Grigorios ULiege

in Journal of Wind Engineering & Industrial Aerodynamics (2017), 166

This work describes the development and application of a 3D unsteady surface panel method with a separation model to the problem of simulating the flow around the blades of a horizontal axis wind turbine ... [more ▼]

This work describes the development and application of a 3D unsteady surface panel method with a separation model to the problem of simulating the flow around the blades of a horizontal axis wind turbine. The present method is intended as a design tool to capture the 3D time-dependent characteristics of both attached and separated flow conditions and is an extension of previous 2D approaches. Flow separation is modelled using a loose coupling procedure between the inviscid panel method and a quasi-3D viscous boundary layer solution. A separated wake is shed at the predicted separation points and propagated at the local flow velocity, just like the trailing edge wake. The methodology is demonstrated on the NREL phase-VI wind turbine test case and the model predictions are compared to experimental measurements. [less ▲]

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See detailEvaluation d'un itinéraire clinique pour collectomie gauche en chirurgie abdominale
Mattart, Laurine; Stevens, Marie; Magis, David ULiege et al

in Revue Médicale de Liège (2017), 72(1), 45-50

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne ... [more ▼]

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne nécessitant une résection du côlon gauche par laparoscopie a été incluse dans cet IC entre 2009 et 2015. Nous nous sommes intéressés à l’observance du protocole de l’IC ainsi qu’aux taux de complications et de ré-hospitalisations dans les 30 jours post-opératoires. Nous avons constaté, après comparaison avec un groupe témoin historique, que l’adhésion au protocole IC a été d’emblée excellente (> 80 %) tout au long de la durée de l’étude. Il n’y a pas eu de modification du taux de ré-hospitalisations et le taux de lâchage de suture a été réduit. Bien que la diminution de la durée de séjour n’était pas l’objectif premier lors de la mise en place de cet IC, elle s’est significativement réduite passant, en moyenne, de 8 à 4 jours. En conclusion, l’introduction d’un IC, pour autant qu’il soit bien préparé et rassemble dans le même objectif l’ensemble des acteurs de soins, est directement bénéfique pour le patient et la qualité de sa prise en charge. [less ▲]

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See detailBeyond stuttering: Speech disfluencies in normally fluent French-speaking children at age 4
Leclercq, Anne-Lise ULiege; Suaire, Pauline; Moyse, Astrid

in Clinical Linguistics & Phonetics (2017)

The aim of this study was to establish normative data on the speech disfluencies of normally fluent French-speaking children at age 4, an age at which stuttering has begun in 95% of children who stutter ... [more ▼]

The aim of this study was to establish normative data on the speech disfluencies of normally fluent French-speaking children at age 4, an age at which stuttering has begun in 95% of children who stutter (Yairi & Ambrose, 2013). Fifty monolingual French-speaking children who do not stutter participated in the study. Analyses of a conversational speech sample comprising 250–550 words revealed an average of 10% total disfluencies, 2% stuttering-like disfluencies and around 8% non-stuttered disfluencies. Possible explanations for these high speech disfluency frequencies are discussed, including explanations linked to French in particular. The results shed light on the importance of normative data specific to each language. [less ▲]

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