References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailPharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2014)

Introduction: Patients with type 2 diabetes have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis and about one-third of cirrhotic patients ... [more ▼]

Introduction: Patients with type 2 diabetes have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis and about one-third of cirrhotic patients have diabetes. However, the use of several antidiabetic agents may be a cause for concern in the case of hepatic impairment (HI). Areas covered: An extensive literature search was performed to analyze the influence of HI on the pharmacokinetics (PK) of glucose-lowering agents and the potential consequences for clinical practice as far as the efficacy/safety balance of their use in diabetic patients with CLD is concerned. Expert opinion: Almost no PK studies have been published regarding metformin, sulfonylureas, thiazolidinediones and alpha-glucosidase inhibitors in patients with HI. Only mild changes in PK of glinides, dipeptidyl peptidase-4 inhibitors and sodium glucose cotransporters type 2 inhibitors were observed in dedicated PK studies in patients with various degrees of HI, presumably without major clinical relevance although large clinical experience is lacking. Glucagon-like peptide-1 receptor agonists have a renal excretion rather than liver metabolism. Rare anecdotal case reports of hepatotoxicity have been described with various glucose-lowering agents contrasting with numerous reassuring data. Nevertheless, caution should be recommended, especially in patients with advanced cirrhosis, including with the use of metformin. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailValidation of real-time PCR for detection of six major pathogens in seafood products
Taminiau, Bernard ULg; Korsak Koulagenko, Nicolas ULg; Lemaire et al

in Food Control (2014), 44

Seafood can pose a public health concern to consumers. It is often consumed rawand may be contaminated with several foodborne pathogens. In order to guarantee the safety of seafood, real-time polymerase ... [more ▼]

Seafood can pose a public health concern to consumers. It is often consumed rawand may be contaminated with several foodborne pathogens. In order to guarantee the safety of seafood, real-time polymerase chain reaction (PCR) protocols may be used as these enable results to be provided within 24 h. The first goal of our work was to develop real-time PCR protocols enabling the detection of six foodborne pathogens that may be present in seafood products (Campylobacter jejuni, Campylobacter coli, enterohemorrhagic Escherichia coli, Salmonella spp., Vibrio parahaemolyticus, and Vibrio vulnificus). The corresponding gene targets were: 50S/VS1, rfbE, ttr, tlh, and vvp. A multiplex PCR was also developed to detect the virulence genes of V. parahaemolyticus: tdh and trh. A total of 420 bacterial strains belonging to four different genera/strains were used in this study. Sensitivity and specificity were always 100%, except in the case of Salmonella spp., where three strains were not detected by our PCR protocols. The second objective of our work was to assess the detection limit of our real-time PCR protocols on artificially contaminated seafood products (raw shrimps, cooked shrimps, and raw mussels), purchased in public stores. Six different levels of contamination were assayed in four replicates for each matrix. The real-time PCR protocols enabled a better level of detection than the ISO methods, except for Salmonella in raw shrimps and for V. vulnificus in shrimps (raw and cooked). The estimated level of detection was between 1 and 47 cfu/25 g sample for the ISO norms and between 1 and 315 cfu/25 g sample for the realtime PCR protocols tailored in our work. The real-time PCRs developed in our work allowed for good selectivity, sensitivity, and specificity. The sensitivity on seafood products was estimated at a level of 100%, except for Salmonella (97%). In the spiking assays, the levels of detection were lower with the real-time PCR protocol than those obtained with the ISO method. This was not the case for V. vulnificus in raw and cooked shrimps and for Salmonella in raw shrimps. These real-time PCR protocols appear to be good alternative methods for surveillance of seafood products to ensure the absence of foodborne pathogens. One additional conclusion is that laboratories have to use enrichment media that are compatible with those recommended by ISO standards. This may facilitate the isolation of the pathogen if the real-time PCR protocol gives a suspect positive signal during the first step of the seafood analysis. [less ▲]

Detailed reference viewed: 36 (15 ULg)
Full Text
Peer Reviewed
See detailDouble sweep preconditioner for optimized Schwarz methods applied to the Helmholtz problem
Vion, Alexandre ULg; Geuzaine, Christophe ULg

in Journal of Computational Physics (2014), 266

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailPractice of enteral nutrition in very low birth weight and extremely low birth weight infants
SENTERRE, Thibault ULg

in World Review of Nutrition and Dietetics (2014), 110

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailA New Look at Ichthyosaur Long Bone Microanatomy and Histology: Implications for Their Adaptation to an Aquatic Life
Houssaye, Alexandra; Scheyer, Torsten; Kolb, Christian et al

in PLoS ONE (2014), 9(4), 95637

Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades ... [more ▼]

Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades. Data concerning their bone microanatomical and histological features are rather limited and suggest that ichthyosaurs display a spongious, “osteoporotic-like” bone inner structure, like extant cetaceans. However, some taxa exhibit peculiar features, suggesting that the analysis of the microanatomical and histological characteristics of various ichthyosaur long bones should match the anatomical diversity and provide information about their diverse locomotor abilities and physiology. Methodology/Principal Findings The material analyzed for this study essentially consists of mid-diaphyseal transverse sections from stylopod bones of various ichthyosaurs and of a few microtomographic (both conventional and synchrotron) data. The present contribution discusses the histological and microanatomical variation observed within ichthyosaurs and the peculiarities of some taxa (Mixosaurus, Pessopteryx). Four microanatomical types are described. If Mixosaurus sections differ from those of the other taxa analyzed, the other microanatomical types, characterized by the relative proportion of compact and loose spongiosa of periosteal and endochondral origin respectively, seem to rather especially illustrate variation along the diaphysis in taxa with similar microanatomical features. Our analysis also reveals that primary bone in all the ichthyosaur taxa sampled (to the possible exception of Mixosaurus) is spongy in origin, that cyclical growth is a common pattern among ichthyosaurs, and confirms the previous assumptions of high growth rates in ichthyosaurs. Conclusions/Significance The occurrence of two types of remodelling patterns along the diaphysis, characterized by bone mass decrease and increase respectively is described for the first time. It raises questions about the definition of the osseous microanatomical specializations bone mass increase and osteoporosis, notably based on the processes involved, and reveals the difficulty in determining the true occurrence of these osseous specializations in ichthyosaurs. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailMethods to Increase the Robustness of Finite-Volume Flow Models in Thermodynamic Systems
Quoilin, Sylvain ULg; Bell, Ian ULg; Desideri, Adriano ULg et al

in Energies (2014), 7(3), 1621-1640

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when ... [more ▼]

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when modeling 1D heat exchangers or piping, e.g., in thermodynamic cycles involving a phase change. Issues, such as chattering or stiff systems, can lead to low simulation speed, instabilities and simulation failures. In the particular case of two-phase flow models, they are usually linked to a discontinuity in the density derivative between the liquid and two-phase zones. In this work, several methods to tackle numerical problems are developed, described, implemented and compared. In addition, methods available in the literature are also implemented and compared to the proposed approaches. Results suggest that the robustness of the models can be significantly increased with these different methods, at the price of a small increase of the error in the mass and energy balances. [less ▲]

Detailed reference viewed: 44 (14 ULg)
Full Text
Peer Reviewed
See detailOutcomes of adults with active or progressive hematological malignancies at time of allogeneic stem cell transplantation : a survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Chevallier, P.; Labopin, M.; Milpied, N. et al

in Bone Marrow Transplantation (2014), 49

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective ... [more ▼]

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective study aimed to analyze the outcome of adult patients who received allo-SCT in a chemo-refractory/relapsed status. The series included 840 patients with active or progressive disease at the time of transplant. Median age was 50 years. With a median follow-up of 40 months, 3-year OS, disease-free survival (DFS), and non-relapse mortality rates were 29±2, 23±2, and 30±2%, respectively. At the last follow-up, 252 patients (30%) were still alive (of whom 201 were in CR (24%). In a Cox multivariate analysis, the use of a reduced-intensity conditioning (RIC) before allo-SCT and use of an HLA-identical sibling donor remained independently associated with a better OS (hazard ratio (HR)¼0.82; 95% confidence interval (CI), 0.69–0.98, P¼0.03; and HR¼0.79; 95% CI, 0.66–0.93, P¼0.006, respectively). Also, a diagnosis of myelodysplastic syndrome/myeloproliferative disorder, Hodgkin lymphoma and non-Hodgkin lymphoma compared with acute leukemia had a favorable impact on OS (HR¼0.55; 95% CI, 0.45–0.68, Po0.0001; HR¼0.49; 95% CI, 0.31–0.75, P¼0.001; and HR¼0.47; 95% CI, 0.35–0.63, Po0.0001, respectively). In conclusion, this study suggests that allo-SCT may be of benefit in some subgroups of patients with active or progressive hematological malignancies at the time of allo-SCT. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailType I error inflation in DIF identification with Mantel-Haenszel: an explanation and a solution
Magis, David ULg; De Boeck, Paul

in Educational & Psychological Measurement (2014), 74

It is known that sum score-based methods for the identification of differential item functioning (DIF), such as the Mantel-Haenszel (MH) approach, can be affected by Type I error inflation in the absence ... [more ▼]

It is known that sum score-based methods for the identification of differential item functioning (DIF), such as the Mantel-Haenszel (MH) approach, can be affected by Type I error inflation in the absence of any DIF effect. This may happen when the items differ in discrimination and when there is item impact. On the other hand, outlier DIF methods have been developed that are robust against this Type I error inflation, while they are still based on the MH DIF statistic. The present paper gives an explanation for why the common MH method is indeed vulnerable to the inflation effect while the outlier DIF versions are not. In a simulation study we were able to produce the Type I error inflation by inducing item impact and item differences in discrimination. At the same time and in parallel with the Type I error inflation the dispersion of the DIF statistic across items was increased. As expected, the outlier DIF methods did not seem sensitive to impact and differences in item discrimination. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailThe political choices of emigrants voting in home country elections: A socio-political analysis of the electoral behaviour of Bolivian external voters
Lafleur, Jean-Michel ULg; Sanchez-Dominguez, Maria

in Migration Studies (2014)

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this ... [more ▼]

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this question remains largely unanswered. Basing ourselves on the existing political science literature on electoral behaviour and on the migration literature on immigrants’ participation in host country politics, we isolate different hypotheses that explain emigrants’ preferences in home country politics. We then build four models of voters based on these hypotheses: the social group voter, the ideological voter, the interest-driven voter, and the transnational voter. In the second part of the paper, we verify the validity of these models using the results of a survey carried out with Bolivian emigrants who took part in the 2009 Bolivian presidential election from abroad. Overall, this article identifies the drivers of immigrant transnational political participation and contributes to current debates on social remittances. [less ▲]

Full Text
Peer Reviewed
See detailIron loss calculation in steel laminations at high frequencies
Henrotte, François; Steentjes, Simon; Hameyer, Kay et al

in IEEE Transactions on Magnetics (2014), 50(2), 333-336

Detailed reference viewed: 6 (2 ULg)
Full Text
Peer Reviewed
See detailThe role of the youth in community forestry in Gabon
Boldrini, Sylvie; Meunier, Quentin; Gillet, Pauline ULg et al

in Nature et Faune (2014), 28(1), 56-59

In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus ... [more ▼]

In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus, communities however rarely integrate the youth (between the ages of 16 to 24) who reside permanently in the village in village associations. The youth are generally excluded from the decision making process of elders. In fact, the youth that reside permanently in the village do not generally hold any diploma and have no professional qualification. Consequently, they are hardly respected by the people around them and their opinions are not taken into account. They are left out of any activity conducted by the associations unless these activities are remunerated. However, the involvement of the youth in village associations is necessary, not only to increase the work capacity, but also to ensure the perpetuation of interventions since the youth will be the first and future beneficiaries of the community forest. [less ▲]

Detailed reference viewed: 71 (20 ULg)
Full Text
Peer Reviewed
See detailBlocking lipid synthesis overcomes tumor re-growth and metastasis after anti-angiogenic therapy withdrawal.
Sounni, Nor Eddine ULg; Cimino, Jonathan ULg; BLACHER, Silvia ULg et al

in Cell Metabolism (2014), 20

The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied transcriptomic, proteomic, and metabolomic approaches ... [more ▼]

The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied transcriptomic, proteomic, and metabolomic approaches to preclinical models and provide evidence for tumor adaptation to vascular endothelial growth factor blockade through a metabolic shift toward carbohydrate and lipid metabolism in tumors. During sunitinib or sorafenib treatment, tumor growth was inhibited and tumors were hypoxic and glycolytic. In sharp contrast, treatment withdrawal led to tumor regrowth, angiogenesis restoration, moderate lactate production, and enhanced lipid synthesis. This metabolic shift was associated with a drastic increase in metastatic dissemination. Interestingly, pharmacological lipogenesis inhibition with orlistat or fatty acid synthase downregulation with shRNA inhibited tumor regrowth and metastases after sunitinib treatment withdrawal. Our data shed light on metabolic alterations that result in cancer adaptation to antiangiogenic treatments and identify key molecules involved in lipid metabolism as putative therapeutic targets. [less ▲]

Detailed reference viewed: 34 (17 ULg)
Full Text
Peer Reviewed
See detailExternal constraints on optical control strategies in molecular orientation and photofragmentation: role of zero-area fields
Sugny, Dominique; Vranckx, Stéphane; Ndong, Mamadou et al

in Journal of Modern Optics (2014), 61

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailInfluence of the surface morphology of smooth platinum electrodes for the sodium borohydride oxidation reaction
Olu, Pierre-Yves; Gilles, Bruno; Job, Nathalie ULg et al

in Electrochemistry Communications (2014), 43

Detailed reference viewed: 58 (2 ULg)
Full Text
Peer Reviewed
See detailEnhanced or Reduced Fetal Growth Induced by Embryo Transfer into Smaller or Larger Breeds Alters Post-Natal Growth and Metabolism in Pre-Weaning Horses
Peugnet, Pauline; Wimel, Laurence; Duchamp, Guy et al

in PLoS ONE (2014), 9(7), 102044

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailQuelles dynamiques d'identification organisationnelle lors de processus de modernisation? Analyse d'une administration belge.
Rondeaux, Giseline ULg

in Revue Internationale des Sciences Administratives [= RISA] (2014), 80(mars), 110-130

In the course of reform, organizational identity emerges as a prominent issue. While the process of modernizing the administration sets out to redefine this identity, how is this experienced by its ... [more ▼]

In the course of reform, organizational identity emerges as a prominent issue. While the process of modernizing the administration sets out to redefine this identity, how is this experienced by its members? What are the identity dynamics at work in terms of their perception of changes in their environment? By analysing the Copernic reform in Belgium, we inductively developed a typology of identity rationales and profiles (Rondeaux, 2006, 2007, 2008, 2010). On this basis, we conducted a questionnaire survey in a regional administration engaged in reform. Our analysis highlights the coexistence of different identity rationales and diverse perceptions of the environment, which are congruent or dissonant with them. The results underline the importance of the environment and of its perception in organizational identification processes and confirms the hypothesis of identity hybridization, providing also an empirical basis for the integrative approach of Ravasi and Schultz (2006). [less ▲]

Detailed reference viewed: 113 (32 ULg)
Full Text
Peer Reviewed
See detailGeometric ferroelectricity in fluoroperovskites
Garcia-Castro, A. C.; Spaldin, Nicola A.; Romero, A. H. et al

in Physical Review B (2014), 89

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are ... [more ▼]

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are paraelectric (Pnma phase), we find that many fluoroperovskites have a ferroelectric instability in their high-symmetry cubic structure that is of similar amplitude to that commonly found in oxide perovskites. In contrast to the oxides, however, the fluorides have nominal Born effective charges, indicating a different mechanism for the instability.We show that the instability originates from ionic size effects, and is therefore in most cases largely insensitive to pressure and strain, again in contrast to the oxide perovskites. An exception is NaMnF3, where coherent epitaxial strain matching to a substrate with equal in-plane lattice constants destabilizes the bulk Pnma structure, leading to a ferroelectric, and indeed multiferroic, ground state with an unusual polarization/strain response. [less ▲]

Detailed reference viewed: 39 (12 ULg)
Full Text
Peer Reviewed
See detailIndirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women.
Ellis, Alexandra G.; Reginster, Jean-Yves ULg; Luo, Xuemei et al

in Current medical research and opinion (2014), 30(8), 1617-1626

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on ... [more ▼]

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on evidence from randomized controlled trials (RCTs). Methods: Eight RCTs assessing vertebral fracture risk reduction with oral bisphosphonates (n = 7) or bazedoxifene (n = 1) were identified by a systematic literature review. Individual study results were pooled in a network meta-analysis (NMA) to indirectly compare treatment effects for overall PMO women and a higher-risk subgroup (FRAX >/= 20%). Three sets of NMA analyses were conducted: aggregate data (AD) from the bisphosphonate RCTs and bazedoxifene RCT for the full population or the FRAX >/=20% subgroup (NMA AD); bisphosphonate AD and bazedoxifene AD from each FRAX subgroup adjusted for baseline risk (NMA AD meta-regression); and bisphosphonate AD and bazedoxifene individual patient data (IPD) adjusted for baseline risk/FRAX (NMA AD/IPD meta-regression). Results: For the overall population, bisphosphonates had lower fracture risks versus bazedoxifene although there is considerable uncertainty in supporting one intervention over another. The relative risk reduction (RRR) for bazedoxifene was -0.23 (95% CrI: -1.11, 0.27) versus ibandronate, -0.17 (-0.76, 0.22) versus alendronate, and -0.06 (-0.62, 0.30) versus risedronate. Results from the meta-regression analyses were similar. For the FRAX >/=20% population, estimated fracture rates with bazedoxifene were lower than with bisphosphonates, but again the uncertainty limits strong interpretation. The RRR for bazedoxifene was 0.51 (-0.31, 0.83) versus ibandronate, 0.53 (-0.18, 0.83) versus alendronate, and 0.57 (-0.07, 0.85) versus risedronate. The meta-regression analyses showed comparable findings. Conclusion: The analyses only considered vertebral fractures for oral bisphosphonates versus bazedoxifene, and IPD was available only for bazedoxifene. In light of this, bazedoxifene is comparable to bisphosphonates in the overall PMO population and at least as effective as bisphosphonates for preventing vertebral fractures among higher-risk PMO patients. The findings suggest bazedoxifene performs better in higher-risk PMO than in the overall PMO. [less ▲]

Detailed reference viewed: 15 (7 ULg)
Full Text
Peer Reviewed
See detailNumerical study of shear band instability and effect of cavitation on the response of a specimen under undrained biaxial loading
Sieffert, Yannick; Buzzi, Olivier; Collin, Frédéric ULg

in International Journal of Solids and Structures (2014), 51(9), 16861696

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailMary Anning’s legacy to French vertebrate palaeontology
Vincent, Peggy; Taquet, Philippe; Fischer, Valentin ULg et al

in Geological Magazine (2014), 151(1), 7-20

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent ... [more ▼]

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent study by eminent English and French scientists. In 1820, Georges Cuvier acquired several ichthyosaur specimens found by Mary Anning, now kept or displayed in the Palaeontology Gallery of the MNHN in Paris. Four years later, Cuvier obtained a plesiosaur specimen from Mary Anning, only the second ever discovered. Cuvier was fascinated by these fossils and their study allowed him to apply his comparative anatomical method and to support his catastrophist theory. We re-examined these important specimens from an historical point of view and herein describe them taxonomically for the first time since Cuvier’s works. The Paris specimens belong to two different ichthyosaur genera (Ichthyosaurus and Leptonectes) and one plesiosaur genus (Plesiosaurus). [less ▲]

Detailed reference viewed: 152 (4 ULg)
Full Text
See detailCompte rendu : Michel FRANCARD, Wallon, picard, gaumais, champenois. Les langues régionales de Wallonie
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2014)

Detailed reference viewed: 32 (3 ULg)
Full Text
Peer Reviewed
See detailRessources naturelles, matières premières et géographie. L'exemple des ressources énergétiques et minières
Deshaies, Michel; Merenne-Schoumaker, Bernadette ULg

in BSGLg (2014), 62

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has ... [more ▼]

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has evolved over time and then analyze new research issues that emerge from a decade. Through this brief analysis, everything indicates a real expansion of fields of investigation, undoubtedly related to the new challenges and opportunities posed by resources that go far beyond the traditional field of economic geography. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detailHeart Valve Clinic: Rationale and Organization.
Lancellotti, Patrizio ULg; Rosenhek, Raphael; Pibarot, Philippe

in The Canadian journal of cardiology (2014)

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The ... [more ▼]

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The HVC is made up of a multidisciplinary team with high expertise in the diagnosis, management, treatment, and surveillance of patients with VHD. The aim of the HVC is to provide the highest quality of care to patients with VHD to improve the level of adherence to current evidence and guidelines, quality of life, and short- and long-term outcomes. The HVC also provides help in (1) informing and educating patients to motivate them to take their prescribed medications and look out for signs indicating a worsening of their disease, (2) organizing meetings for updates in knowledge for modern management of patients with VHD, and (3) disseminating protocols of contemporary and good practice in VHD. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailPAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Bajou, Khalid ULg; Herkenne, Stéphanie ULg; Thijssen, Victor L. et al

in Nature Medicine (2014), sous presse

The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor ... [more ▼]

The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor angiogenesis and growth. Loss of PAI-1 abrogated the antitumoral and antiangiogenic effects of 16K PRL. PAI-1 bound the ternary complex PAI-1-urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR), thereby exerting antiangiogenic effects. By inhibiting the antifibrinolytic activity of PAI-1, 16K PRL also protected mice against thromboembolism and promoted arterial clot lysis. Thus, by signaling through the PAI-1-uPA-uPAR complex, 16K PRL impairs tumor vascularization and growth and, by inhibiting the antifibrinolytic activity of PAI-1, promotes thrombolysis. [less ▲]

Detailed reference viewed: 24 (12 ULg)
Full Text
Peer Reviewed
See detailTo settle or to move? The interplay between two classes of cyclic lipopeptides in the biocontrol strain Pseudomonas CMR12a
D’aes, J.; Phuong Kieu, N.; Leclère, V. et al

in Environmental Microbiology (2014), In press

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailPhysicochemical characterization and in vitro assessment of the nutritive value of starch yield from corn dried at different temperatures
Malumba, P.; Odjo, S.; Boudry, Christelle ULg et al

in Stärke = Starch (2014), 66

To assess modifications induced in starch granules during high temperature drying of corn grain and their effect on the nutritive value of corn-starch, physicochemical and structural characteristics of ... [more ▼]

To assess modifications induced in starch granules during high temperature drying of corn grain and their effect on the nutritive value of corn-starch, physicochemical and structural characteristics of starch granules from corn grains dried at different temperatures have been determined. Additionally, their in vitro digestibility and fermentation patterns were investigated, using a two steps in vitro model of the pig digestive tract. High drying temperatures induced a partial gelatinization of starch granules and produced a very favorable substrate for porcine pancreatic amylase and led to an altered physical structure which affected the rate and extent of starch granules digestion by gastric and pancreatic enzymes. Starch micrographs showed that granules extracted from corn dried at 130°C were less angular, bigger, and had smoother surface than granules extracted from corn dried at lower temperature. High-temperature drying increased the digestibility of wet-milled starch granules, while the residues of starch from corn dried at lower temperature produced higher volume of gas during their in vitro fermentation, despite their more pronounced crystalline characteristic. The residues from pepsin–pancreatic digestion of overall samples analyzed showed highly degraded and pitted granules or fragmented external shells, starch from corn dried at 130°C being the most degraded. Aforementioned changes of nutritional attributes of starch granules are discussed according to the restructuration occurring within both their amorphous and crystalline phase, as well as to the changes of the granules size and purity. [less ▲]

Detailed reference viewed: 5 (4 ULg)
Full Text
Peer Reviewed
See detailShort communication: Alteration of priors for random effects in Gaussian linear mixed models
Vandenplas, Jérémie ULg; Christensen, Ole F.; Gengler, Nicolas ULg

in Journal of Dairy Science (2014), 97(9), 5880-5884

Linear mixed models, for which the prior multivariate normal distributions of random effects are assumed to have a mean equal to 0, are commonly used in animal breeding. However, some statistical analyses ... [more ▼]

Linear mixed models, for which the prior multivariate normal distributions of random effects are assumed to have a mean equal to 0, are commonly used in animal breeding. However, some statistical analyses (e.g., the consideration of a population under selection into a genomic scheme breeding, multiple-trait predictions of lactation yields, Bayesian approaches integrating external information into genetic evaluations) need to alter both the mean and (co)variance of the prior distributions and, to our knowledge, most software packages available in the animal breeding community do not permit such alterations. Therefore, the aim of this study was to propose a method to alter both the mean and (co)variance of the prior multivariate normal distributions of random effects of linear mixed models while using currently available software packages. The proposed method was tested on simulated examples with three different software packages available in animal breeding. The examples showed the possibility of the proposed method to alter both the mean and (co)variance of the prior distributions with currently available software packages through the use of an extended data file and a user supplied (co)variance matrix. [less ▲]

Detailed reference viewed: 13 (8 ULg)
Full Text
Peer Reviewed
See detailScreening for malnutrition in lung cancer patients undergoing therapy
BARTHELEMY, Nicole ULg; Streel, Sylvie ULg; Donneau, Anne-Françoise ULg et al

in Supportive Care in Cancer (2014), 22(6), 15311536

Detailed reference viewed: 20 (11 ULg)
Full Text
Peer Reviewed
See detailInterdisciplinary approaches to the phenomenology of auditory verbal hallucinations
Woods, A; Jones, N; Bernini, M et al

in Schizophrenia Bulletin (2014), 40

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailNew Amphiphilic Neamine Derivatives Active against Resistant Pseudomonas aeruginosa and Their Interactions with Lipopolysaccharides
Sautrey, Guillaume; Zimmerman, Louis; Deleu, Magali ULg et al

in Antimicrobial Agents and Chemotherapy (2014), 58(8), 4420-4430

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailThe Rank Minrelation Coefficient
Meyer, Patrick ULg

in Quality Technology & Quantitative Management (2014), 11

Detailed reference viewed: 19 (5 ULg)
Full Text
See detailA clinically novel AIP mutation in a patient with a very large, apparently sporadic somatotrope adenoma.
Salvatori, Roberto; Daly, Adrian ULg; Quinones-Hinojosa, Alfredo et al

in Endocrinology, diabetes & metabolism case reports (2014), 2014

Heterozygous germline inactivating mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene lead to pituitary adenomas that most frequently present in the setting of familial isolated ... [more ▼]

Heterozygous germline inactivating mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene lead to pituitary adenomas that most frequently present in the setting of familial isolated pituitary adenoma syndrome, usually as somatotropinomas and prolactinomas. More recently, they have been found in a significant percentage of young patients presenting with pituitary macroadenoma without any apparent family history. We describe the case of a 19-year-old man who presented with a gigantic somatotropinoma. His family history was negative. His peripheral DNA showed a heterozygous AIP mutation (p.I13N), while tumor tissue only had the mutated allele, showing loss of heterozygosity (LOH) and suggesting that the mutation caused the disease. LEARNING POINTS: AIP mutations may be observed in sporadic somatotrope adenomas occurring in young patients.LOH is a strong indicator that an AIP variant is disease causing.Somatotrope adenomas in carriers of AIP mutations are generally larger and more difficult to cure. [less ▲]

Detailed reference viewed: 5 (2 ULg)
Full Text
Peer Reviewed
See detailThe influence of equivalent contact area computation in extended node to surface contact elements
Wautelet, Gaëtan ULg; Ponthot, Jean-Philippe ULg

in Key Engineering Materials [=KEM] (2014), 618

This article aims at extending the node to surface formulation for contact problems with an area regularization as proposed by [1]. For that purpose, two methods are proposed to compute the equivalent ... [more ▼]

This article aims at extending the node to surface formulation for contact problems with an area regularization as proposed by [1]. For that purpose, two methods are proposed to compute the equivalent contact area attributed to each slave node. The first method, which is based on a geometrical approach through force equivalence, is an original extension of the one proposed in [1] for two-dimensional contact problems, i.e. plane stress and plane strain state, to the axisymmetric modelling context. The second method relies on an energy consistent way obtained through the virtual work principle and the same expression for the equivalent contact area as the one originally cited in [2] is then recovered. First, the node to surface strategy with area regularization is introduced and the aforementioned methods for the equivalent contact area are presented in detail and compared. Afterwards a consistent linearization technique is applied to achieve a quadratic convergence rate in the Newton Raphson iterative procedure used to solve the non-linear equilibrium equations of the underlying finite element model. Finally, two axisymmetric numerical examples are provided in order to compare the aforementioned equivalent contact area evaluations and to demonstrate the performance and the robustness of the consistent approach especially in the neighbourhood the revolution axis. [less ▲]

Detailed reference viewed: 22 (2 ULg)
Full Text
Peer Reviewed
See detailHuman brucellosis in North-West Ecuador : typifying of Brucella spp., sero-prevalence, and associated risk factors
Ron Roman, J.; Ron Garrido, L.; Abatih, E. et al

in Vector Borne & Zoonotic Diseases (2014), 14(2),

Detailed reference viewed: 37 (2 ULg)
See detailEvidence-based practice: fondements et réflexions sur l’apport en clinique.
Maillart, Christelle ULg; Durieux, Nancy ULg

in Langage et Pratiques (2014), 53

L’evidence-based practice ou pratique basée sur les preuves est une approche de plus en plus encouragée en logopédie au niveau international. Cet article présente les principaux composants en détaillant ... [more ▼]

L’evidence-based practice ou pratique basée sur les preuves est une approche de plus en plus encouragée en logopédie au niveau international. Cet article présente les principaux composants en détaillant la nature des preuves liées aux trois piliers de l’EBP (preuves externes, preuves internes ou préférences du patient). La démarche de l’EBP est brièvement discutée ainsi que les freins et les bénéfices attendus en clinique. [less ▲]

Detailed reference viewed: 33 (4 ULg)
Full Text
Peer Reviewed
See detailThe evaluation of vocal pitch accuracy: The case of operatic singing voices
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Music Perception (2014), 32(1), 1-10

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices ... [more ▼]

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices, which have particularly complex acoustical signals. Twenty-two music experts were asked to evaluate the vocal pitch accuracy of 14 sung performances with a pairwise comparison paradigm, in a test and a retest. In addition to the objective measurement of pitch accuracy (pitch interval deviation), several performance parameters (average tempo, fundamental frequency of the starting note) and quality parameters (energy distribution, vibrato rate and extent) were observed and compared to the judges’ perceptual rating. The results show high intra- and inter-judge reliability when rating the pitch accuracy of operatic singing voices. Surprisingly, all the parameters were significantly related to the ratings and explain 78.8% of the variability of the judges’ rating. The pitch accuracy evaluation of operatic voices is thus not based exclusively on the precision of performed music intervals but on a complex combination of performance and quality parameters. [less ▲]

Detailed reference viewed: 26 (9 ULg)
Full Text
Peer Reviewed
See detailAntioxidant Activity of Compounds Isolated from the Root Woods of Erythrina droogmansiana
Yaya, AJG; Feumba, RD; Emmanuel, T et al

in International Journal of Pharmaceutical Sciences and Drug Research (2014), 6(2), 160-163

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract ... [more ▼]

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract and isolated compounds. The phytochemical study led to the isolation of 3-(3’,4’-methelenedioxyphenyl)-2,3-epoxypropanol (1), asperphenamate (2) and three flavonoids namely genistein, diadzein and 4’,5,7-trihydroxy-8-prenylisoflavone. These compounds were characterized using their 1H NMR, 13C NMR, HMBC, HSQC, COSY, mass spectral and the literature. To evaluate antioxidant activity of crude extract and isolated compounds, the radical scavenging (DPPH) and Ferric Reducing Ability Power (FRAP) were performed using ascorbic acid as standard. Compounds 1 and 2 showed moderate radical scavenging potential with IC50 value of 3.14 and 3.31 mg/ml respectively, and moderate reducing power ability with value of 0.14±0.01 mgAAE/mg and 0.21±0.01 mgAAE/mg respectively. The more active compound was genistein (3) with IC50 value of 1.96 mg/ml for the DPPH radical scavenging potential and 0.24±0.02 mgAAE/mg for its ability to reduce iron. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailStrychnobaillonine, an Unsymmetrical Bisindole Alkaloid with an Unprecedented Skeleton from Strychnos icaja Baill. Roots
Tchinda Tiabou, Alembert ULg; Jansen, Olivia ULg; Nyemb, Jean-Noel et al

in Journal of Natural Products (2014), 77

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailIn vitro embryo production in goats: slaughterhouse and laparoscopic ovum pick up 2 (LOPU) derived oocytes have different kinetics and requirements regarding maturation 3 media
Souza-Fabjan, JM; Locatelli, Y; Duffard, N et al

in Theriogenology (2014), 81

A total of 3427 goat oocytes were used in this study in order to identify possible 24 differences during in vitro embryo production from slaughterhouse or laparoscopic ovum 25 pick up (LOPU) oocytes. In ... [more ▼]

A total of 3427 goat oocytes were used in this study in order to identify possible 24 differences during in vitro embryo production from slaughterhouse or laparoscopic ovum 25 pick up (LOPU) oocytes. In Experiment 1, one complex, one semi defined and one simplified 26 in vitro maturation (IVM) media were compared using slaughterhouse oocytes. In 27 Experiment 2, we checked the effect of oocyte origin (slaughterhouse or LOPU) on the 28 kinetics of maturation (18 vs. 22 vs. 26 h) when submitted to semi defined or simplified 29 media. In Experiment 3, we determined the differences in embryo development between 30 slaughterhouse and LOPU oocytes when submitted to both media and then to in vitro 31 fertilization (IVF) or parthenogenetic activation (PA). Embryos from all groups were vitrified 32 and their viability evaluated in vitro after thawing. In Experiment 1, no difference (P>0.05) 33 was detected among treatments for maturation rate (MII; 88% on average), cleavage (72%), 34 blastocyst from the initial number of cumulus oocyte complexes (COC; 46%) or from the 35 cleaved ones (63%), hatching rate (69%) and the total number of blastomeres (187). In 36 Experiment 2, there was no difference of MII rate between slaughterhouse oocytes cultured 37 for 18 or 22 h, whereas the MII rate increased significantly (P<0.05) between 18 and 22 h for 38 LOPU oocytes in the simplified medium. Moreover, slaughterhouse oocytes cultured in 39 simplified medium matured significantly faster than LOPU oocytes at 18 and 22 h (P<0.05). 40 In Experiment 3, cleavage rate was significantly greater (P<0.001) in all four groups of 41 embryos produced by PA than IVF. Interestingly, PA reached similar rates for slaughterhouse 42 oocytes cultured in both media, but improved (P<0.05) cleavage rate of LOPU oocytes. 43 Slaughterhouse oocytes had acceptable cleavage rate after IVF (~67%), whereas LOPU 44 oocytes displayed a lower one (~38%), in contrast to cleavage after PA. The percentage of 45 blastocysts in relation to cleaved embryos was not affected by the origin of the oocytes 46 (P>0.05). Therefore, slaughterhouse oocytes developed a greater proportion of blastocysts than LOPU ones, expressed as the percentage of total COC entering to IVM. Vitrified-thawed 48 blastocysts presented similar survival and hatching rates between the oocyte origin, media or 49 method of activation. In conclusion, slaughterhouse and LOPU derived oocytes may have 50 different IVM kinetics and require different IVM-IVF conditions. Although the IVM and IVF 51 systems still need improvements in order to enhance embryo yield, the in vitro development 52 (IVD) step is able to generate good quality embryos from LOPU derived oocytes. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailMaria Davis. El humor en las novelas de Gabriel García Márquez
Vanden Berghe, Kristine ULg

in Bulletin of Spanish Studies (2014), 91(6), 956-957

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailThe anagenetic world of spore-producing land plants
Patino Llorente, Jairo ULg; Carine, M.A.; Fernández-Palacios, J.M. et al

in New Phytologist (2014), 201

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailRecommandations europeennes concernant la therapie de resynchronisation cardiaque.
ROBINET, Sébastien ULg; DELCOUR, Alexandre ULg; Lancellotti, Patrizio ULg

in Revue medicale de Liege (2014), 69(4), 180-7

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In ... [more ▼]

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In this article, we summarize the recommendations of the European Society of Cardiology of 2013 on cardiac resynchronization therapy. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailA 3-D Semi-Implicit Method for Computing the Current Density in Bulk Superconductors
Kameni, Abelin; Boubekeur, Mohamed; Alloui, Lotfi et al

in IEEE Transactions on Magnetics (2014), 50(2), 377--380

Detailed reference viewed: 11 (6 ULg)
Full Text
Peer Reviewed
See detailRisk ranking priority of carcinogenic and/or genotoxic environmental contaminants in food in Belgium
Vromman, V; Maghuin-Rogister, Guy ULg; Vleminckx, C et al

in Food Additives & Contaminants. Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment (2014)

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailClick-Evoked Otoacoustic Emissions in Children and Adolescents with Gender Identity Disorder.
Burke, Sarah M.; Menks, Willeke M.; Cohen-Kettenis, Peggy T. et al

in Archives of sexual behavior (2014)

Click-evoked otoacoustic emissions (CEOAEs) are echo-like sounds that are produced by the inner ear in response to click-stimuli. CEOAEs generally have a higher amplitude in women compared to men and ... [more ▼]

Click-evoked otoacoustic emissions (CEOAEs) are echo-like sounds that are produced by the inner ear in response to click-stimuli. CEOAEs generally have a higher amplitude in women compared to men and neonates already show a similar sex difference in CEOAEs. Weaker responses in males are proposed to originate from elevated levels of testosterone during perinatal sexual differentiation. Therefore, CEOAEs may be used as a retrospective indicator of someone's perinatal androgen environment. Individuals diagnosed with Gender Identity Disorder (GID), according to DSM-IV-TR, are characterized by a strong identification with the other gender and discomfort about their natal sex. Although the etiology of GID is far from established, it is hypothesized that atypical levels of sex steroids during a critical period of sexual differentiation of the brain might play a role. In the present study, we compared CEOAEs in treatment-naive children and adolescents with early-onset GID (24 natal boys, 23 natal girls) and control subjects (65 boys, 62 girls). We replicated the sex difference in CEOAE response amplitude in the control group. This sex difference, however, was not present in the GID groups. Boys with GID showed stronger, more female-typical CEOAEs whereas girls with GID did not differ in emission strength compared to control girls. Based on the assumption that CEOAE amplitude can be seen as an index of relative androgen exposure, our results provide some evidence for the idea that boys with GID may have been exposed to lower amounts of androgen during early development in comparison to control boys. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailMonte-Cristo chimiste et physicien des communications : du télégraphe optique au télégraphe électrique
Durand, Pascal ULg

in Cahiers Alexandre Dumas (2014), 41

La scène du télégraphe optique, dans Le Comte de Monte-Cristo, aide à mettre en lumière la modernité du roman. Cette modernité tient pour une part à une ligne de continuité établie entre chronique ... [more ▼]

La scène du télégraphe optique, dans Le Comte de Monte-Cristo, aide à mettre en lumière la modernité du roman. Cette modernité tient pour une part à une ligne de continuité établie entre chronique judiciaire et fable romanesque, sur fond de réseau télégraphique. Elle tient plus encore au fait que cet épisode du télégraphe rend singulièrement visible l’allégorie de la communication que le roman développe à différents niveaux de sa construction narrative, allant de son incipit très sémiologique à la « voile blanche » qui signalera sur fond d’azur méditerranéen, quatorze cents pages plus loin, le départ d’un Monte-Cristo ayant recouvré son identité perdue, en passant par les deux figures successivement incarnées par son héros, dépeint en victime sacrificielle puis en expert d’une communication dont il saura jouer de tous les ressorts — rapidité de déplacement, contrôle de l’information, maîtrise des formes spéculatives et fiduciaires de l’économie, dévoiement des formes anthropologiques de l’échange social, etc. — pour l’emporter finalement sur les trois pouvoirs coalisés de la Politique (Morcerf), de la Justice (Villefort) et de la Banque (Danglars) ; tout cela orchestré par une triple métaphore du sang, de l’argent et de l’information, dont la signification réversible ne peut être séparée d’une doctrine saint-simonienne que Dumas à la fois relaie et révoque. De même que le couloir de communication établi au château d’If entre la cellule de Dantès et celle de Faria, la scène du télégraphe fait ainsi office de point de cristallisation d’une symbolique diffuse. Cette scène si cardinale, il s'agit ici de montrer qu’elle est non seulement grosse encore de tout un savoir à dimension technique autant qu’anthropologique, mais également porteuse, vers d’autres zones du roman, d’une assez étonnante préfiguration du télégraphe électrique, en cheville avec une modernité technique dont Dumas faufile les signes de façon plus ou moins cryptée dans la trame de son roman. [less ▲]

Detailed reference viewed: 234 (60 ULg)
Full Text
See detailSaint-Ghislain/Sirault : les polissoirs romains découverts en 1998, indices d'une forge spécialisée ?
Thiebaux, Aurélie ULg; Ansieau, Cécile; Henrich, Peter et al

in Chronique de l'Archéologie Wallonne (2014), 21

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailEstimation of dominance variance for live body weight in a crossbred population of pigs
Dufrasne, Marie ULg; Faux, Pierre ULg; Piedboeuf, Maureen et al

in Journal of Animal Science (2014), 92

The objective of this study was to estimate the dominance variance for repeated live BW records in a crossbred population of pigs. Data were provided by the Walloon Pig Breeding Association and included ... [more ▼]

The objective of this study was to estimate the dominance variance for repeated live BW records in a crossbred population of pigs. Data were provided by the Walloon Pig Breeding Association and included 22,197 BW records of 2,999 crossbred Piétrain × Landrace K+ pigs from 50 to 210 d of age. The BW records were standardized and adjusted to 210 d of age for analysis. Three single-trait random regression animal models were used: Model 1 without parental subclass effect, Model 2 with parental subclasses considered unrelated, and Model 3 with the complete parental dominance relationship matrix. Each model included sex, contemporary group, and heterosis as fixed effects as well as additive genetic, permanent environment, and residual as random effects. Variance components and their SE were estimated using a Gibbs sampling algorithm. Heritability tended to increase with age: from 0.50 to 0.64 for Model 1, from 0.19 to 0.42 for Model 2, and from 0.31 to 0.53 for Model 3. Permanent environmental variance tended to decrease with age and accounted for 29 to 44% of total variance with Model 1, 29 to 37% of total variance with Model 2, and 34 to 51% of total variance with Model 3. Residual variance explained <10% of total variance for the 3 models. Dominance variance was computed as 4 times the estimated parental subclass variance. Dominance variance accounted for 22 to 40% of total variance for Model 2 and 5 to 11% of total variance for Model 3, with a decrease with age for both models. Results showed that dominance effects exist for growth traits in pigs and may be reasonably large. The use of the complete dominance relationship matrix may improve the estimation of additive genetic variances and breeding values. Moreover, a dominance effect could be especially useful in selection programs for individual matings through the use of specific combining ability to maximize growth potential of crossbred progeny. [less ▲]

Detailed reference viewed: 6 (3 ULg)
Full Text
Peer Reviewed
See detailA Statistically adaptive sampling policy to the Hotelling's T2 Control Chart: Markov Chain Approach
Seif, A.; Faraz, Alireza ULg; Heuchenne, Cédric ULg et al

in Communications in Statistics : Theory & Methods (2014)

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailPhysiological and proteomic responses of different willow clones (Salix fragilis x alba) exposed to dredged sediment contaminated by heavy metals
Evlard, Aricia ULg; Sergeant, Kjell; Ferrandis, Salvador et al

in International Journal of Phytoremediation (2014), 16(11), 1148-1169

High biomass producing species are considered as tools for remediation of contaminated soils. Willows (Salix spp.) are prominent study subjects in this regard. In this study, different willow clones ... [more ▼]

High biomass producing species are considered as tools for remediation of contaminated soils. Willows (Salix spp.) are prominent study subjects in this regard. In this study, different willow clones (Salix fragilis x alba) were planted on heavy-metal polluted dredging sludge. A first objective was assessment of the biomass production for these clones. Using a Gupta statistic, four clones were identified as high biomass producers (HBP). For comparison, a group of four clones with lowest biomass production were selected (LBP). A second objective was to compare metal uptake as well as the physiological and proteomic responses of these two groups. All these complementary data's allow us to have a better picture of the health of the clones that would be used in phytoremediation programs. Cd, Zn, and Ni total uptake was higher in the HBPs but Pb total uptake was higher in LBPs. Our proteomic and physiological results showed that the LBPs were able to maintain cellular activity as much as the HBPs although the oxidative stress response was more pronounced in the LBPs. This could be due to the high Pb content found in this group although a combined effect of the other metals cannot be excluded. [less ▲]

Detailed reference viewed: 32 (0 ULg)
Full Text
Peer Reviewed
See detailEffect of the kinematic hardening in the simulations of the straightening of long rolled profiles
Bouffioux, Chantal ULg; Boman, Romain ULg; Caillet, Nicolas et al

in Key Engineering Materials [=KEM] (2014), 611-612

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are ... [more ▼]

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are straightened using a series of rollers placed alternately above and below the pieces with shifts which create a succession of bendings. The process is modeled to study the impact of the industrial parameters ( the duration of the cooling and the rollers positions), to improve the final geometry and to reduce the residual stresses.Tests are carried out on this structural steel to observe the material behavior, then material laws are chosen and parameters of these laws are defined using and inverse method. Two sets of material data are obtained: for the first one, the hardening is supposed to be isotropic, and for the second one, additional tests are performed to describe isotropic and kinematic hardenings.The cooling followed by the straightening is then simulated by the finite element with these two sets of date. The comparison of the rollers forces, the deformation and the residual stresses show the impact of the kinematic hardening on such a process where the material undergoes a sucession of the tensions and compressions. The real forces applied by the rollers,the real curvature of the interlocks at the end of the straightening process and the distribution of the residual longitudinal stresses measured on the web using the ring core method are used to validate the numerical model. [less ▲]

Detailed reference viewed: 15 (7 ULg)
Full Text
Peer Reviewed
See detailFlexible estimation in cure survival models using Bayesian P-splines
Bremhorst, Vincent; Lambert, Philippe ULg

in Computational Statistics & Data Analysis (2014)

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an ... [more ▼]

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an unknown proportion of the population under study will never experience the monitored event. The promotion time model, which has a biological motivation, is one of the survival models taking this feature into account. The promotion time model assumes that the failure time of each subject is generated by the minimum of N independent latent event times with a common distribution independent of N. An extension which allows the covariates to influence simultane- ously the probability of being cured and the latent distribution is presented. The latent distribution is estimated using a flexible Cox proportional hazard model where the logarithm of the baseline hazard function is specified using Bayesian P-splines. Introducing covariates in the latent distribution implies that the population hazard function might not have a proportional hazard structure. However, the use of P- splines provides a smooth estimation of the population hazard ratio over time. The identification issues of the model are discussed and a restricted use of the model when the follow up of the study is not sufficiently long is proposed. The accuracy of our methodology is evaluated through a simulation study and the model is illustrated on data from a Melanoma clinical trial. [less ▲]

Detailed reference viewed: 17 (4 ULg)
Full Text
Peer Reviewed
See detailNew role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline ULg; Renert, Anne-Françoise; Merville, Marie-Paule ULg et al

in Autophagy (2014)

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]

Detailed reference viewed: 95 (18 ULg)
Full Text
Peer Reviewed
See detailThe anorectic effects of alpha-lipoicacid are mediated by central AMPK and are not due to taste aversion in chicken (Gallus gallus)
Wang, Y.; Song, Z.; Everaert, Nadia ULg et al

in Physiology & Behavior (2014), 132

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailSpatial Planning as a driver of change in mobility and residential energy consumption
Dujardin, Sébastien; Marique, Anne-Françoise ULg; Teller, Jacques ULg

in Energy & Buildings (2014), 68

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning ... [more ▼]

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning decisions upon energy consumption in both residential building stock and home-to-work commuting. The analysis has been conducted on a regional scale (16,844 km2) and includes urban, peri-urban and rural settlements. Those settlements that perform well in mobility also appear to perform well in terms of building energy consumption. Even though this is not generally the case, it further reveals that some rural settlements characterized by low density show good performance in terms of energy efficiency. This permits a much more progressive approach in terms of spatial planning, whereby compact cities may be viewed as part of the solution, albeit not the whole solution. [less ▲]

Detailed reference viewed: 135 (64 ULg)
Full Text
See detailGermanistik und Sprachlandschaft in Belgien
Küpper, Achim ULg

in Newsletter des Deutschen Germanistenverbands (2014), (1), 14-16

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailAphid honeydew: An arrestant and a contact kairomone for Episyrphus balteatus (Diptera: Syrphidae) larvae and adults
Leroy, Pascal; Almohamad, Raki; Attia, Sabrine et al

in European Journal of Entomology (2014), 111(2), 237-242

Predator searching efficiency increases in response to a variety of environmental cues associated with its prey. The sugary excretion of aphids (honeydew) has been found to act as a prey-associated cue ... [more ▼]

Predator searching efficiency increases in response to a variety of environmental cues associated with its prey. The sugary excretion of aphids (honeydew) has been found to act as a prey-associated cue for many aphid natural enemies. In the present study, the honeydew excreted by Acyrthosiphon pisum (Harris) was identified as an arrestant and a contact kairomone for young larvae and adults of a common predatory hoverfly, Episyrphus balteatus (De Geer) (Diptera: Syrphidae). First and second instar larvae increased their foraging behaviour in the honeydew-treated area. When plants were sprayed with crude honeydew, the speed of movement of female E. balteatus was significantly higher than in controls, resulting in a longer period of time spent on treated plants and laying eggs. We conclude that the honeydew excreted by A. pisum induces searching behaviour and acts as and arrestant not only for adults but also for young E. balteatus larvae. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailBridging physiological and evolutionary time-scales in a gene regulatory network.
Marchand, Gwenaelle; Huynh-Thu, Vân Anh ULg; Kane, Nolan C. et al

in The New phytologist (2014)

Gene regulatory networks (GRNs) govern phenotypic adaptations and reflect the trade-offs between physiological responses and evolutionary adaptation that act at different time-scales. To identify patterns ... [more ▼]

Gene regulatory networks (GRNs) govern phenotypic adaptations and reflect the trade-offs between physiological responses and evolutionary adaptation that act at different time-scales. To identify patterns of molecular function and genetic diversity in GRNs, we studied the drought response of the common sunflower, Helianthus annuus, and how the underlying GRN is related to its evolution. We examined the responses of 32 423 expressed sequences to drought and to abscisic acid (ABA) and selected 145 co-expressed transcripts. We characterized their regulatory relationships in nine kinetic studies based on different hormones. From this, we inferred a GRN by meta-analyses of a Gaussian graphical model and a random forest algorithm and studied the genetic differentiation among populations (FST ) at nodes. We identified two main hubs in the network that transport nitrate in guard cells. This suggests that nitrate transport is a critical aspect of the sunflower physiological response to drought. We observed that differentiation of the network genes in elite sunflower cultivars is correlated with their position and connectivity. This systems biology approach combined molecular data at different time-scales and identified important physiological processes. At the evolutionary level, we propose that network topology could influence responses to human selection and possibly adaptation to dry environments. [less ▲]

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailAADOPEASE : un acronyme des compétences des soignants-éducateurs en ETP
Leclercq, Dieudonné ULg

in Education Thérapeutique du Patient [=ETP] = Therapeutic Patient Education [=TPE] (2014), 6(1), 1-10

Introduction: Competencies (functions) endorsed by TPE professional actors can be summarized in 9 (French) words, that can be easily memorized as an acronym:AADOPEASE, referring (in French) to Announcing ... [more ▼]

Introduction: Competencies (functions) endorsed by TPE professional actors can be summarized in 9 (French) words, that can be easily memorized as an acronym:AADOPEASE, referring (in French) to Announcing, Accueil (welcoming), Diagnosis (of educational needs), Objectives, Planning, Education, Apprentissage (Learning), Suivi (Coaching) and Evaluation. Objectives: This acronym is intended to facilitate the analysis of existing therapeutic education tasks and the conception of future ones, including training programs for educational care givers. Description: After conceptual precisions on terms such as competencies, capacities, situations, tasks, activities, resources, each of the AADOPEASE competencies is summarized and commented. Conclusions: In the perspective of offering a convenient bird view of a training program in TPE, the present approach, focused on objectives would offer a summary that should be completed by such a one on training and educating methods and on evaluation methods. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailGynecologic and obstetric impact of the Ehlers-Danlos syndrome: clues from scrutinizing dermal ultrastructural alterations.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Gynecology (2014), 2(1),

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective ... [more ▼]

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissue fragility. Each EDS type corresponds to a multisystemic disorder with widespread implications. Physicians evoke the EDS diagnosis in presence of some typical cutaneous signs, such as atrophic scars and frequent hematomas. Methods: To revisit the transmission electron microscopy support from skin biopsies when screening EDS in gynecology-obstetrics. Results: EDS women commonly suffer from a series of gynecologic and obstetric disorders. Dermal ultrastructural changes are keynote features suggesting some EDS types. Conclusion: Gene mutations are mostly identified in the classic and vascular EDS types, but only in sporadic cases of the hypermobile EDS type which apparently represents the most frequent type. Dermal ultrastructural changes represent relevant diagnostic clues for the practitioner. Preconception counseling about possible complications is welcome. Management requires precise diagnosis of the EDS type. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Full Text
See detailUn monde entre accélération et incertitudes
Santander, Sébastian ULg

in Interventions Economiques = Papers in Political Economy (2014)

Detailed reference viewed: 29 (5 ULg)
Full Text
Peer Reviewed
See detailForkhead pathway in the control of adult neurogenesis.
Genin, Emmanuelle C.; Caron, Nicolas ULg; Vandenbosch, Renaud ULg et al

in Stem cells (Dayton, Ohio) (2014)

Detailed reference viewed: 1 (0 ULg)
Full Text
Peer Reviewed
See detailInfluence de l'environnement et des pratiques culturales sur la productivité de Jatropha curcas L. en Afrique subsaharienne (synthèse bibliographique)
Minengu, Jean de Dieu; Mobambo, Patrick; Mergeai, Guy ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 290-300

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the ... [more ▼]

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the development of the plants was low and yields during the first years of cultivation were mostly disappointing. The low yields obtained in marginal conditions led to the belief that the cultivation of Jatropha could only be profitable in areas with fertile soils and sufficiently humid climates, which would place the plants in direct competition with food production. This article analyzes the available scientific knowledge regarding the ecological and technical factors influencing the productivity of J. curcas and suggests possible solutions for improving its performance in sub-Saharan Africa. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailQuand le savoir s'emmêle... La construction discursive de la norme chez les locuteurs non experts
Meunier, Deborah ULg; Rosier, Laurence

in Carnets du Cediscor (2014), 12

Detailed reference viewed: 30 (7 ULg)
Full Text
Peer Reviewed
See detailGas dissolution in antibubble dynamics
scheid, benoit; zawala, jan; Dorbolo, Stéphane ULg

in Soft Matter (2014), 10

Detailed reference viewed: 36 (6 ULg)
Full Text
Peer Reviewed
See detailEl sindrome tirogastrico autoinmune : sus efectos sobre los micronutrientes y la tumorigenesis gastrica
VALDES SOCIN, Hernan Gonzalo ULg; LUTTERI, Laurence ULg; Cavalier, Etienne ULg et al

in Revista Argentina de Endocrinologia y Metabolismo (2014), 51

Detailed reference viewed: 23 (2 ULg)
Full Text
Peer Reviewed
See detailAccuracy of one-step integration schemes for damped/forced linear structural dynamics
Depouhon, Alexandre ULg; Detournay, Emmanuel; Denoël, Vincent ULg

in International Journal for Numerical Methods in Engineering (2014)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailSPECT/CT workflow and imaging protocols.
Beckers, Catherine; Hustinx, Roland ULg

in European journal of nuclear medicine and molecular imaging (2014), 41

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow ... [more ▼]

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow processes and the revision of original scheduling process and imaging protocols. In addition, the imaging protocol should be adapted for each individual patient, so that performing CT is fully justified and the CT procedure is fully tailored to address the clinical issue. Such refinements often occur before the procedure is started but may be required at some intermediate stage of the procedure. Furthermore, SPECT/CT leads in many instances to a new partnership with the radiology department. This article presents practical advice and highlights the key clinical elements which need to be considered to help understand the workflow process of SPECT/CT and optimise imaging protocols. METHODS: The workflow process using SPECT/CT is complex in particular because of its bimodal character, the large spectrum of stakeholders, the multiplicity of their activities at various time points and the need for real-time decision-making. RESULTS: With help from analytical tools developed for quality assessment, the workflow process using SPECT/CT may be separated into related, but independent steps, each with its specific human and material resources to use as inputs or outputs. This helps identify factors that could contribute to failure in routine clinical practice. At each step of the process, practical aspects to optimise imaging procedure and protocols are developed. A decision-making algorithm for justifying each CT indication as well as the appropriateness of each CT protocol is the cornerstone of routine clinical practice using SPECT/CT. CONCLUSION: In conclusion, implementing hybrid SPECT/CT imaging requires new ways of working. It is highly rewarding from a clinical perspective, but it also proves to be a daily challenge in terms of management. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailLe renoncement au désir de maternité comme issue possible d’une conflictualité intrapsychique
Delli Gatti, Tamara ULg; Naziri, Despina ULg

in Dialogue : Recherches Cliniques et Sociologiques sur le Couple et la Famille (2014), 204

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailEffect of land use on pollution status and risk of fish endocrine disruption in small farmland ponds
Mandiki; Gillardin; Martens et al

in Hydrobiologia (2014), 723

Detailed reference viewed: 22 (4 ULg)
Full Text
Peer Reviewed
See detailLa culture comme objet
Badir, Sémir ULg

in Semiotica (2014), 198

La culture peut-elle être un objet d’étude à part entière ? Les sciences de la culture le donnent implicitement à penser par leur intitulé même, à l’instar de ce qu’ont poursuivi, à l’égard de leurs ... [more ▼]

La culture peut-elle être un objet d’étude à part entière ? Les sciences de la culture le donnent implicitement à penser par leur intitulé même, à l’instar de ce qu’ont poursuivi, à l’égard de leurs objets respectifs, les sciences de l’homme, de la société et de la vie. Une telle objectivation, toutefois, ne va pas de soi, les caractères définitoires de la culture — à la fois comme totalité et comme singularité — dérogent à l’objectivation scientifique ordinaire. Dans un premier temps, on commence par considérer trois tentatives d’objectivation de la culture menées en sémiotique, sous le rapport de la sémiosphère (Lotman), de l’esthésie (Rastier) et de la langue. Le crédit accordé à la troisième tentative nous invite à interroger, dans un second temps, le rapport entre langue, texte et culture à partir de la distinction théorique proposée par Hjelmslev entre analyse et fragmentation. Langue, texte et culture sont fonction d’un seul objet empirique pour lesquelles différentes focalisations sont possibles. C’est une fonction restreinte et analytique qui règle le rapport des textes à la langue ; au contraire c’est une fonction extensive, fragmentée et synthétique qui laisse voir les textes comme des œuvres insérées dans les pratiques de la culture. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailA one phase thermomechanical model for the numerical simulation of semi-solid material behavior. Application to thixoforming
Koeune, Roxane; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2014), 58

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called ... [more ▼]

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called thixotropy that can be displayed by some metallic alloys heated up to their semi-solid state. It is a particular evolutionary behavior which is characterized by a solidlike behavior at rest and a liquid flow during shearing, thus by a decrease of the viscosity and of the resistance to deformation while sheared. An original one-phase thermo-elasto-viscoplastic constitutive model has been developed. The basic idea is to extend the classical isotropic hardening and viscosity models beyond the solid state by considering two more non-dimensional internal scalar parameters. The semi-solid state is treated as a particular case, and one of the main features of the proposed constitutive model is that it remains valid over a wide range of temperatures, starting from room temperature to above the liquidus in a continuous manner, thus allowing a continuous transition between classical solid and fluid behavior. Another feature is that, after the forming step, it is possible to simulate the cooling down of the component back to room temperature using the elastic–viscoplastic model. So it is possible to estimate residual stresses, something that is definitely impossible while using a fluid-like model or a rigid viscoplastic approach. The presented model is illustrated and validated by means of representative numerical applications, as two different extrusion tests are carried out and the computed predictions are compared to experimental results. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailCompte rendu de Han BALTUSSEN, Michael ATKINSON, Michael SHARE, Ian MUELLER (trad.), Simplicius: On Aristotle Physics 1.5-9
Gavray, Marc-Antoine ULg

in International Journal of the Platonic Tradition (2014), 8(1), 115-117

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailL'électroneuromyographie dans la pathologie de la face dorsale du pied
WANG, François-Charles ULg

in Médecine et Chirurgie du Pied = Foot Medicine and Surgery (2014), (30), 86-89

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailComprehensive plasma profiling for the characterization of graft-versus-host disease biomarkers
De Bock, Muriel; BEGUIN, Yves ULg; Leprince, Pierre ULg et al

in Talanta (2014), 125

Acutegraft-versus-hostdisease(aGVHD)remainsalife-threateningcomplicationofhematopoieticstem cell transplantation(HSCT)thereforelimitingitsapplication.TooptimizethemanagementofaGVHDand reduce therapy ... [more ▼]

Acutegraft-versus-hostdisease(aGVHD)remainsalife-threateningcomplicationofhematopoieticstem cell transplantation(HSCT)thereforelimitingitsapplication.TooptimizethemanagementofaGVHDand reduce therapy-relatedtoxicity,earlyspecific markersareneeded.Themainobjectiveofthisstudywas to uncoverdiagnosticbiomarkersbycomparingplasmaproteinprofiles ofpatientsatthetimeofacute GVHDdiagnosiswiththoseofpatientsundergoingHSCTwithoutaGVHD.Additionalanalysisofsamples taken 15daysbeforeaGVHDdiagnosiswasalsoperformedtoevaluatethepotentialofournewly discoveredbiomarkersforearlydiagnosis.Togetcomplementaryinformationfromplasmasamples, we usedthreedifferentproteomicapproaches,namely2D-DIGE,SELDI-TOF-MSand2D-LC-MSE. Weidentified andconfirmed bythemeansofindependenttechniques,thedifferentialexpression of severalproteinsindicatingsignificantly increasedinflammation responseanddisturbanceinthe coagulation cascade.Thevariationoftheseproteinswasalreadyobserved15daysbeforeGVHD diagnosis, suggestingthepotentialearlydetectionofthediseasebeforesymptomsappearance. Finally,logisticregressionanalysisdeterminedacompositebiomarkerpanelcomprising fibrinogen, fragment of fibrinogenbetachain,SAA,prothrombinfragments,apolipoproteinA1andhepcidinthat optimallydiscriminatedpatientswithandwithoutGVHD.Theareaunderthereceiveroperating characteristiccurvedistinguishingthese2groupswas0.95. [less ▲]

Detailed reference viewed: 28 (13 ULg)
Full Text
Peer Reviewed
See detailBone forming agents for the management of osteoporosis
Reginster, Jean-Yves ULg; Neuprez, A.; Beaudart, Charlotte ULg et al

in Panminerva medica (2014), 56(2), 97-114

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these ... [more ▼]

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these medications provide only limited fracture reduction and may be linked to skeletal and non-skeletal long-term safety concerns. Therefore, some patients are considered candidates for bone-forming agents because they remain severely osteoporotic or because they failed antiresorptive therapy. Over the last decade, a particular interest was shown in the developmentofmedicationsabletoincreaseosteoblastsnumber,lifespan or activity, hence stimulating bone formation Peptides from the parathyroid hormone family and strontium ranelate were shown to significantly reduce fracture rates but strontium ranelate is no longer an option for treating osteoporosis because of its safety profile. New therapeutic options, including monoclonal antibodies against sclerostin seem to be promising but their role in the armamentarium of osteoporosis will depend on the results of the current phase 3 studies, assessing antifracture efficacy and long-term safety. [less ▲]

Detailed reference viewed: 23 (10 ULg)
Full Text
Peer Reviewed
See detailCusp observation at Saturn’s high-latitude magnetosphere by the Cassini spacecraft
Jasinski; Arridge; Lamy et al

in Geophysical Research Letters (2014)

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailUn complexe d’espèces d’Afzelia des forêts africaines d’intérêt économique et écologique (synthèse bibliographique)
Donkpegan, Segbedji ULg; Hardy, J. Olivier; Lejeune, Philippe ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2),

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The ... [more ▼]

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The distribution of Afzelia species in Africa suggests that the tree has made various adaptations due to ecological factors. However, on the basis of only vegetative criteria, it is difficult to distinguish species in forest inventory, and this could compromise the sustainable management approach promoted by the populations of Central African countries. We show that the genus remains generally understudied, although some of its species are considered by the IUCN as being under threat. Therefore, the ecological and genetic aspects of our investigations should prove relevant to the future cultivation of Afzelia. [less ▲]

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailMarcos, la botarga. ¿Avatar o despedida del Subcomandante?
Vanden Berghe, Kristine ULg

in Asociación para el Fomento de los Estudios Históricos en Centroamérica (2014), 60

Se evalúa hasta qué punto la despedida del Sucomandante Marcos en mayo de 2014 se inscribe en la continuación de un discurso anterior o se desvía de él.

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detailLong-term fracture rates seen with continued ibandronate treatment : pooled analysis of DIVA and MOBILE long-term extension studies
Miller, PD; Recker, RR; Harris, S et al

in Osteoporosis International (2014), 25(1), 349-357

Detailed reference viewed: 32 (3 ULg)
Full Text
Peer Reviewed
See detailMarcos, la botarga. ¿Avatar o despedida del Subcomandante?
Vanden Berghe, Kristine ULg

in Asociación para el Fomento de los Estudios Históricos en Centroamérica (2014), 60

Se evalúa hasta qué punto la despedida del Sucomandante Marcos en mayo de 2014 se inscribe en la continuación de un discurso anterior o se desvía de él.

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detailRecommendations for transoesophageal echocardiography: EACVI update 2014.
Flachskampf, Frank A.; Wouters, Patrick F.; Edvardsen, Thor et al

in European heart journal cardiovascular Imaging (2014), 15(4), 353-65

With this document, we update the recommendations for transoesophageal echocardiography (TOE) of the European Association of Cardiovascular Imaging. The document focusses on the areas of interventional ... [more ▼]

With this document, we update the recommendations for transoesophageal echocardiography (TOE) of the European Association of Cardiovascular Imaging. The document focusses on the areas of interventional TOE, in particular transcatheter aortic, mitral, and left atrial appendage interventions, as well as on the role of TOE in infective endocarditis, adult congenital heart disease, and aortic disease. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
See detailDeletion of exons 1-3 of the MEN1 gene in a large Italian family causes the loss of menin expression.
Zatelli, Maria Chiara; Tagliati, Federico; Di Ruvo, Mauro et al

in Familial cancer (2014)

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to ... [more ▼]

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to inactivating mutations of the MEN1 gene (chromosome 11q13). MEN1 mutations are mainly represented by nonsense, deletions/insertions, splice site or missense mutations that can be detected by direct sequencing of genomic DNA. However, MEN1 patients with large heterozygous deletions may escape classical genetic screening and may be misidentified as phenocopies, thereby hindering proper clinical surveillance. We employed a real-time polymerase chain reaction application, the TaqMan copy number variation assay, to evaluate a family in which we failed to identify an MEN1 mutation by direct sequencing, despite a clear clinical diagnosis of MEN1 syndrome. Using the TaqMan copy number variation assay we identified a large deletion of the MEN1 gene involving exons 1 and 2, in three affected family members, but not in the other nine family members that were to date clinically unaffected. The same genetic alteration was not found in a group of ten unaffected subjects, without family history of endocrine tumors. The MEN1 deletion was further confirmed by multiplex ligation-dependent probe amplification, which showed the deletion extended from exon 1 to exon 3. This new approach allowed us to correctly genetically diagnose three clinical MEN1 patients that were previously considered as MEN1 phenocopies. More importantly, we excluded the presence of genetic alterations in the unaffected family members. These results underline the importance of using a variety of available biotechnology approaches when pursuing a genetic diagnosis in a clinically suggestive setting of inherited endocrine cancer. [less ▲]

Detailed reference viewed: 19 (5 ULg)
Full Text
See detailUrtica jacta est : quelques mots de la quatrième édition du concours facultaire de dissertation et d'éloquence
Deprez, Christophe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 1

Ce bref compte rendu évoque la quatrième édition du concours de dissertation et d'éloquence organisé par le personnel scientifique de la Faculté de droit, de science politique et de criminologie de l ... [more ▼]

Ce bref compte rendu évoque la quatrième édition du concours de dissertation et d'éloquence organisé par le personnel scientifique de la Faculté de droit, de science politique et de criminologie de l'Universté de Liège (2013-2014). [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailThe promise of wearable activity sensors to define patient recovery.
Appelboom, Geoff; Yang, Annie H.; Christophe, Brandon R. et al

in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2014), 21

The recent emergence of mobile health - the use of mobile telecommunication and wireless devices to improve health outcomes, services, and research - has inspired a patient-centric approach to monitor ... [more ▼]

The recent emergence of mobile health - the use of mobile telecommunication and wireless devices to improve health outcomes, services, and research - has inspired a patient-centric approach to monitor health metrics. Sensors embedded in wearable devices are utilized to acquire greater self-knowledge by tracking basic parameters such as blood pressure, heart rate, and body temperature as well as data related to exercise, diet, and psychological state. To that end, recent studies on utilizing wireless fitness activity trackers to monitor and promote functional recovery in patients suggest that collecting up-to-date performance data could help patients regain functional independence and help hospitals determine the appropriate length of stay for a patient. This manuscript examines existing functional assessment scales, discusses the use of activity tracking sensors in evaluating functional independence, and explores the growing application of wireless technology in measuring and promoting functional recovery. [less ▲]

Detailed reference viewed: 26 (12 ULg)
Full Text
Peer Reviewed
See detailPlant Water Uptake in Drying Soils
Lobet, Guillaume ULg; Couvreur, Valentin; Meunier, Félicien et al

in Plant Physiology (2014), in press

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailA note on abelian returns in rotation words
Rampersad, Narad; Rigo, Michel ULg; Salimov, Pavel ULg

in Theoretical Computer Science (2014), 528

Pursuing the study started by Rigo, Salimov and Vandomme, we use elementary number-theoretic techniques to characterize rotation words having a finite set of abelian returns to all prefixes. We also make ... [more ▼]

Pursuing the study started by Rigo, Salimov and Vandomme, we use elementary number-theoretic techniques to characterize rotation words having a finite set of abelian returns to all prefixes. We also make the connection between the three gap theorem and the number of semi-abelian returns for Sturmian words, simplifying some arguments developed by Puzynina and Zamboni. [less ▲]

Detailed reference viewed: 72 (9 ULg)
Full Text
Peer Reviewed
See detailElectrochemical Co-Deposition of Phosphonate-Modified Carbon Nanotubes and Tantalum on Nitinol
Maho, Anthony ULg; Detriche, Simon; Fonder, Grégory et al

in ChemElectroChem (2014), 1(5), 896--902

Nitinol substrates are coated with thin surface films made of carbon nanotubes (CNTs) and tantalum (Ta), with the aim of fostering their osseointegration aptitudes. Exceptional mechanical and chemical ... [more ▼]

Nitinol substrates are coated with thin surface films made of carbon nanotubes (CNTs) and tantalum (Ta), with the aim of fostering their osseointegration aptitudes. Exceptional mechanical and chemical characteristics of CNTs combined with the resistance to corrosion and strong bioactive properties of tantalum allow for the generation of adherent, protective and functional layers on metallic biomaterial platforms. The composite coatings are elaborated on Nitinol through a two-step electrochemical protocol; firstly, through the electrophoretic deposition of phosphonate-modified CNTs and, secondly, with electrodeposition of Ta. As a preliminary step, phosphonate groups, acting, in addition, as specific Ta-capture entities, are introduced on the CNT sidewalls by means of diazonium derivatives, which imply no hard oxidative treatment. X-ray photoelectron spectroscopy as well as scanning and transmission electronic microscopies are used to analyse the chemical composition, structure and morphology of the different layers. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailAccuracy of asymptotic standard errors of the maximum and weighted likelihood estimators of proficiency levels with short tests
Magis, David ULg

in Applied Psychological Measurement (2014), 38

The maximum likelihood (ML) and the weighted likelihood (WL) estimators are commonly used to obtain proficiency level estimates with pre-calibrated item parameters. Both estimators have the same ... [more ▼]

The maximum likelihood (ML) and the weighted likelihood (WL) estimators are commonly used to obtain proficiency level estimates with pre-calibrated item parameters. Both estimators have the same asymptotic standard error (ASE) that can be easily derived from the expected information function of the test. However, the accuracy of this asymptotic formula is uncertain with short tests when only a few items are administered. The purpose of this paper is to compare the ASE of these estimators to their exact values, evaluated at the proficiency level estimates. The exact SE is computed by generating the full exact sample distribution of the estimators, so its practical feasibility is limited to small tests (except under the Rasch model). A simulation study was conducted to compare the ASE and the exact SE of the ML and WL estimators, to the “true” SE (i.e., computed as the exact SE with the true proficiency levels). It is concluded that with small tests, the exact SEs are less biased and return smaller root mean squared error values than the asymptotic SEs, while as expected the two estimators return similar results with longer tests. [less ▲]

Detailed reference viewed: 26 (5 ULg)
Full Text
Peer Reviewed
See detailA dynamical energy-based hysteresis model for iron loss calculation in laminated cores
Steentjes, S.; Henrotte, F.; Geuzaine, Christophe ULg et al

in International Journal of Numerical Modelling (2014), 27(3), 433-443

Detailed reference viewed: 7 (2 ULg)
Full Text
Peer Reviewed
See detailSarcopénie. Quoi de neuf en 2014 ?
Beaudart, Charlotte ULg; GILLAIN, Sophie ULg; Petermans, Jean ULg et al

in Revue Médicale de Liège (2014), 69(5-6), 251-257

Detailed reference viewed: 22 (6 ULg)