References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailDevelopmental defects in zebrafish for classification of EGF pathway inhibitors.
Pruvot, Benoist ULg; Curé, Yoann ULg; Djiotsa, Joachim et al

in Toxicology and Applied Pharmacology (2014), 274

Detailed reference viewed: 23 (7 ULg)
Full Text
Peer Reviewed
See detailFaire cohabiter les objets sans domicile fixe. Chisholm et les logiques meinongiennes
Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(6), 85-111

Detailed reference viewed: 20 (0 ULg)
Full Text
Peer Reviewed
See detailThe EU and the shifts of power in the international order: challenges and responses
Santander, Sébastian ULg

in European Foreign Affairs Review (2014), 19(1), 65-82

This article revisits the debate about the place of Europe on the international stage. Faced with the growing power of emerging countries, what place can the European Union (EU) hope to occupy? In other ... [more ▼]

This article revisits the debate about the place of Europe on the international stage. Faced with the growing power of emerging countries, what place can the European Union (EU) hope to occupy? In other words, is the world in the process of developing outside Europe, or is Europe positioning itself as one of the principal centres of the international order? In attempting to answer this vast and complex question, the article will examine three points.The first will look at the distribution of global power through the rise of emerging powers. Second, it will examine Europe in the light of changes affecting the international order. There are opposing interpretations.The vision of a Europe in decline is contrasted with arguments that present the Union of twenty-eight Member States as one of the leading poles of the new, emerging international order.The exaggerated nature of these visions persuaded us to favour a third way – that of a European player with relative influence, but ‘under construction’. [less ▲]

Detailed reference viewed: 29 (4 ULg)
Full Text
Peer Reviewed
See detailIntense pulsed light in infantile hemangiomas.
PAQUET, Philippe ULg; Caucanas, Marie; FRANCHIMONT, Claudine ULg et al

in Open Access Journal of Science and Technology (2014), 2

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of ... [more ▼]

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of well-suited beta-blockers, as well as noncoherent light and laser therapies. The aim of this work was to revisit the effect of intense pulsed light (IPL) therapy on infantile hemangioma. Information was collected from the peer-reviewed literature and illustrated by personal cases. When applied early in the evolution of infantile hemangiomas, IPL treatment stops the growth phase and induces regression with minimal cosmetic adverse effects and psychological damage. Initiating an adequate treatment is important because damage due to hemangiomas can be diminished by a timely and adequate approach. Beta-blockers have revolutionized the therapeutic strategy of infantile hemangiomas. The flash light therapy (IPL) represents an alternative therapy for some patients. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailChemical and biological evaluation of the nutritive value of Algerian green seaweed Ulva lactuca using in vitro gas production technique fior ruminant animals
Zitouni, Hind; Arhab, Rabah; Boudry, Christelle ULg et al

in International Journal of Advanced Research (2014), 2(4), 916-925

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to ... [more ▼]

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to vetch-oat hay (control), using in vitro gas production technique. Seaweed and control were incubated with rumen liquor taken from fistulated and non lactating cows. Gas production was recorded at: 2, 4, 6, 8, 12, 24, 48 and 72h. The in vitro rumen fermentation parameters were measured after 24h and 72h of fermentation. Proteins degradability was investigated by the enzymatic technique using a protease extracted from Streptomyces griseus. The results showed a wide variation between the chemical components of seaweed and conventional fodder used as control. The main constituents in Ulva lactuca were ashes (39.1% DM), fibers (22.8 % DM) and proteins (15.3% DM). The gas production profile of seaweed during 72h of incubation showed a slow and low gas production. Cumulative gas production obtained after 24h for seaweed (42 ml/g OM) was significantly lower than control (128.4 ml/g OM) (P<0.001). pH, ammonia, volatile fatty acids (VFAs), apparent digestibility of dry matter (DDM), organic matter digestibility (OMD) and metabolizable energy (ME) were significantly different between seaweed and vetch-oat hay (6.86, 290.1 mg/ml, 1.25 mmol/g DM, 38.3%, 29.2%, 3.81MJ/Kg DM respectively for seaweed). Protein degradability measurement indicates the weak hydrolysis of seaweed crude protein which is beneficial for ruminants. This study showed that the use of Ulva lactuca as non conventional feed in ruminant nutrition can be considered under certain conditions. [less ▲]

Detailed reference viewed: 28 (1 ULg)
Full Text
Peer Reviewed
See detailObservation <–> Text(e) <–> Culture. Introduction
Badir, Sémir ULg

in Semiotica (2014), 198

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailThe value of disturbance-tolerant cercopithecine monkeys as seed dispersers in degraded habitats
Albert, Aurélie; McConkey, Kim; Savini, Tommaso ULg et al

in Biological Conservation (2014), 170

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailCoherent Backscattering in Fock Space: A Signature of Quantum Many-Body Interference in Interacting Bosonic Systems
Engl, Thomas; Dujardin, Julien ULg; Argüelles, Arturo et al

in Physical Review Letters (2014), 112

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with ... [more ▼]

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with respect to variations of external parameters even though it represents a dynamical manifestation of the delicate superposition principle in Fock space. It is a genuine quantum many-body effect that lies beyond the reach of any mean-field approach. Using a semiclassical approach based on interfering paths in Fock space, we calculate the magnitude of the backscattering peak and its dependence on gauge fields that break time-reversal invariance. We confirm our predictions by comparing them to exact quantum evolution probabilities in Bose-Hubbard models, and discuss their relevance in the context of many-body thermalization. [less ▲]

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailEssai de synthèse de rôles de l'élevage pastoral au Sahel et en Afrique de l'Ouest
Laouali, Abdoulkadri ULg; Yamba, Boubacar; Chabi Toko, Roukayath et al

in Annales de l'Université Abdou Moumouni de Niamey, Série B Lettres et Sciences Humaines (2014), Numéro spécial

Throughout the world, livestock plays an important role in socio-economic life and dietary balance of the population especially in the Sahel and West Africa countries characterized by extensive pastoral ... [more ▼]

Throughout the world, livestock plays an important role in socio-economic life and dietary balance of the population especially in the Sahel and West Africa countries characterized by extensive pastoral farming. Across the literature, this activity appears to be subjected to various controversies including its contribution to the degradation of the environment; greenhouse gas emissions; its low economic performance; etc. This article attempts to state the debate through a literature review showing the importance of pastoral livestock in the economics of the Sahel and West Africa countries as well as in household alimentation and the fight against poverty. Also, it noticed the importance and efficiency of pastoral practice in a precariously natural environment such as the Sahel area [less ▲]

Detailed reference viewed: 30 (4 ULg)
Full Text
Peer Reviewed
See detailRecommadantions européennes concernant la thérapie de resynchronisation cardiaque
ROBINET, Sébastien ULg; DELCOUR, Alexandre ULg; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2014), 69(4), 180-187

La thérapie de resynchronisation cardiaque (CRT) est l'une des plus grandes avancées thérapeutiques depuis ces 25 dernières années dans le domaine de l'insuffisance cardiaque. Elle est applicable chez ... [more ▼]

La thérapie de resynchronisation cardiaque (CRT) est l'une des plus grandes avancées thérapeutiques depuis ces 25 dernières années dans le domaine de l'insuffisance cardiaque. Elle est applicable chez plus de 25-30% des patients décompensés cardiaques symptomatiques. Dans cet article, nous détaillons les recommandations de la Société Européenne de Cardiologie 2013 concernant la thérapie de resynchronisation cardiaque. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Peer Reviewed
See detailInteractions of lipases with milk fat globule membrane monolayers using a Langmuir film balance
Danthine, Sabine ULg; Blecker, Christophe ULg

in International Dairy Journal (2014), 35(1), 81-87

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailReproductive ecology of Coula edulis Baill., source of a valuable non-timber forest product
Moupela, Christian ULg; Doucet, Jean-Louis ULg; Daïnou, Kasso ULg et al

in Tropical Ecology (2014), 55(3), 327-338

The reproductive ecology of Coula edulis (Olacaceae), source of a highly valuable non-timber product for African populations, has been investigated on a large tree sample size in a Gabonese forest for a 3 ... [more ▼]

The reproductive ecology of Coula edulis (Olacaceae), source of a highly valuable non-timber product for African populations, has been investigated on a large tree sample size in a Gabonese forest for a 3-year period, in order to propose options for its domestication. Reproduction is annual and the minimum tree diameter for flowering was 10.6 cm while the diameter for regular fructification was 23 cm. The annual diameter increment (ADI; mean = 0.22 cm year-1) was affected by crown exposure, but not by initial tree diameter or fruit production. Tree diameter influenced fruiting frequency and fruit production. There was a strong correlation between fruit production of 2011 and 2012 (Pearson's r = 0.85; P < 0.001), suggesting a high heritability of that trait. Phenotypical selection should be performed prior to any propagation activity. Moreover, as most of C. edulis fruits were sterile (64 %), we propose that sylvicultural strategies should be based on vegetative propagation. [less ▲]

Detailed reference viewed: 80 (55 ULg)
Full Text
Peer Reviewed
See detailThe Dimethylsulfide Cycle in the Eutrophied Southern North Sea: A Model Study Integrating Phytoplankton and Bacterial Processes
Gypens, N; Borges, Alberto ULg; Speeckaert, Gaëlle ULg et al

in Plos One (2014), 9(1)(e85862 DOI: 10.1371/journal.pone.0085862),

We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical ... [more ▼]

We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical processes (including DMS air-sea exchange). This module was integrated in the MIRO ecological model and applied in a 0D frame in the Southern North Sea (SNS). The DMS(P) module is built on parameterizations derived from available knowledge on DMS(P) sources, transformations and sinks, and provides an explicit representation of bacterial activity in contrast to most of existing models that only include phytoplankton process (and abiotic transformations). The model is tested in a highly productive coastal ecosystem (the Belgian coastal zone, BCZ) dominated by diatoms and the Haptophyceae Phaeocystis, respectively low and high DMSP producers. On an annual basis, the particulate DMSP (DMSPp) production simulated in 1989 is mainly related to Phaeocystis colonies (78%) rather than diatoms (13%) and nanoflagellates (9%). Accordingly, sensitivity analysis shows that the model responds more to changes in the sulfur:carbon (S:C) quota and lyase yield of Phaeocystis. DMS originates equally from phytoplankton and bacterial DMSP-lyase activity and only 3% of the DMS is emitted to the atmosphere. Model analysis demonstrates the sensitivity of DMS emission towards the atmosphere to the description and parameterization of biological processes emphasizing the need of adequately representing in models both phytoplankton and bacterial processes affecting DMS(P) dynamics. This is particularly important in eutrophied coastal environments such as the SNS dominated by high non-diatom blooms and where empirical models developed from data-sets biased towards open ocean conditions do not satisfactorily predict the timing and amplitude of the DMS seasonal cycle. In order to predict future feedbacks of DMS emissions on climate, it is needed to account for hotspots of DMS emissions from coastal environments that, if eutrophied, are dominated not only by diatoms. [less ▲]

Detailed reference viewed: 3 (1 ULg)
Full Text
Peer Reviewed
See detailA new Lower Cretaceous ichthyosaur from Russia reveals skull shape conservatism within Ophthalmosaurinae
Fischer, Valentin ULg; Arkhangelsky, Maxim; Uspensky, Gleb et al

in Geological Magazine (2014), 151(1), 60-70

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late ... [more ▼]

Ophthalmosaurinae is a recently recognized clade of derived ichthyosaurs (marine reptiles) ranging from the Bajocian (Middle Jurassic) to the late Albian (late Early Cretaceous). Whereas the Middle-Late Jurassic ophthalmosaurine Ophthalmosaurus is often regarded as a hyperspecialized deep diver, very little is known about the anatomy, evolutionary history, and ecology of Cretaceous ophthalmosaurines because of the scarcity of the fossils and the lack of well-preserved skull material. Here, we describe the skull of a new basal ophthalmosaurine ichthyosaur, Leninia stellans gen. et sp. nov., from the lower Aptian of western Russia, and compare the ocular characteristics of ophthalmosaurids. Leninia is recovered as a basal ophthalmosaurine; it possesses unique traits such as star-shaped frontal–parietal sutures as well as features previously thought to be unique to Ophthalmosaurus such as a supratemporal–stapes contact. A large sclerotic aperture – significantly bigger than in platypterygiine ophthalmosaurids and similar to that of the largest-eyed modern animals (giant and colossal squids) – and reduced dentition appear widespread within ophthalmosaurines. This conservatism suggests ophthalmosaurine ophthalmosaurids occupied similar ecological niche(s) throughout their long evolutionary history. [less ▲]

Detailed reference viewed: 144 (10 ULg)
Peer Reviewed
See detailThe Role of Memory Traces Quality in Directed Forgetting: A Comparison of Young and Older Participants
Collette, Fabienne ULg; Grandjean, Julien; Lorant, Caroline ULg et al

in Psychologica Belgica (2014), 54(4), 310-327

The presence of a reduced directed-forgetting (DF) effect in normal aging has been frequently observed with the item method. These results were interpreted as age-related difficulties in inhibiting the ... [more ▼]

The presence of a reduced directed-forgetting (DF) effect in normal aging has been frequently observed with the item method. These results were interpreted as age-related difficulties in inhibiting the processing of irrelevant information. However, since the performance of older adults is usually lower on items to remember, the age effect on DF abilities could also be interpreted as reflecting memory problems. Consequently, the present study aimed at investigating the influence of memory traces quality on the magnitude of the DF effects in normal aging. We predicted that increasing the quality of memory traces (by increasing presentation times at encoding) would be associated with attenuated DF effects in older participants due to the increased difficulty of inhibiting highly activated memory traces. A classical item-method DF paradigm was administered to 48 young and 48 older participants under short and long encoding conditions. Memory performance for information to memorize and to suppress was assessed with recall and recognition procedures, as well as with a Remember/Know/Guess (RKG) paradigm. The results indicated that, when memory traces are equated between groups, DF effects observed with the recall, recognition and RKG procedures are of similar amplitude in both groups (all ps>0.05). This suggests that the decreased DF effect previously observed in older adults might not actually depend on their inhibitory abilities but may rather reflect quantitative and qualitative differences in episodic memory functioning. [less ▲]

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging. Part I.
Edvardsen, Thor; Plein, Sven; Saraste, Antti et al

in European heart journal cardiovascular Imaging (2014), 15(7), 730-735

The new multimodality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here, we summarize the most important studies from the journal's second year in ... [more ▼]

The new multimodality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here, we summarize the most important studies from the journal's second year in two articles. Part I of the review will focus on studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging, and Part II will focus on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailVibronic Valence and Rydberg Transitions in Geminal Chloro-Fluoro-Ethene (1,1-C2H2FCl). A Spectroscopic and Quantum Chemical Investigation.
Locht, Robert ULg; Dehareng, Dominique ULg; Leyh, Bernard ULg

in Molecular Physics (2014), 112(11), 1520-1539

The vacuum UV photoabsorption spectrum of 1,1-C2H2FCl has been examined in detail between 5 eV and 15 eV photon energy by using synchrotron radiation dispersed by three different monochromators. Quantum ... [more ▼]

The vacuum UV photoabsorption spectrum of 1,1-C2H2FCl has been examined in detail between 5 eV and 15 eV photon energy by using synchrotron radiation dispersed by three different monochromators. Quantum chemical calculations are performed to help in the analysis of the valence/Rydberg transitions region centered at 7.05 eV including the 3a”(pi)→pi* and the 3a” (pi*)→3s Rydberg transitions. Interactions between states involving transitions to the 3s, 4d and sigma* orbitals are identified. A vibrational analysis is proposed for the structures belonging to these transitions. For the pi(3a”)→pi* transition, one vibrational progression is observed with ω3=1410±50 cm-1 and its lowest excitation energy is determined at about 6.398±0.003 eV. The pi(3a”)→3s Rydberg transition is characterized by a single progression with ω3= 1410±80 cm-1 likely starting at about 6.45 eV. These vibrations are ascribed to the C=C stretching motion. The abundant structure observed in the spectrum between 7.8 eV and 10.5 eV has been analyzed in terms of vibronic transitions to ns (δ= 0.97), np (δ= 0.63 and 0.40) and nd (δ= 0.13 and -0.11) Rydberg states which belong to series converging to the 1,1-C2H2FCl+( 2A”) ionic ground state. The analysis of the vibrational structure of the individual Rydberg states has been attempted leading to average values of the wavenumbers ω3= 1 420±20 cm-1, ω7= 720±50 cm-1 and ω9= 390±50 cm-1. Between 10.5 eV and 12.5 eV nine other Rydberg states converging to the 1,1-C2H2FCl+ ( 2A') first excited state were analyzed by the same way. The vibrational structure of these Rydberg states results from the excitation of one vibrational normal mode ν7 with an average value of ω7= 520±20 cm-1 which is assigned to the C-Cl stretching vibration as inferred from quantum chemical calculations. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailDeterminants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.
Voilliot, Damien; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014)

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the ... [more ▼]

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. METHODS AND RESULTS: We prospectively enrolled 63 patients with SSc (age 54+/-3years, 76% female) followed in CHU Sart-Tilman in Liege. All patients underwent graded semi-supine exercise echocardiography. Systolic pulmonary arterial pressure (sPAP) was derived from the peak velocity of the tricuspid regurgitation jet and adding the estimation of right atrial pressure, both at rest and during exercise. Resting pulmonary arterial hypertension (PH) was defined as sPAP >35mmHg and EIPH as sPAP >50mmHg during exercise. The following formulas were used: mean PAP (mPAP)=0.61xsPAP+2, left atrial pressure (LAP)=1.9+1.24xleft ventricular (LV) E/e' and pulmonary vascular resistance (PVR)=(mPAP-LAP)/LV cardiac output (CO) and slope of mPAP-LVCO relationship=changes in mPAP/changes in LVCO. Resting PH was present in 3 patients (7%) and 21 patients developed EIPH (47%). Patients with EIPH had higher resting LAP (10.3+/-2.2 versus 8.8+/-2.3mmHg; p=0.03), resting PVR (2.6+/-0.8 vs. 1.4+/-1.1Woods units; p=0.004), exercise LAP (13.3+/-2.3 vs. 9+/-1.7mmHg; p<0.0001), exercise PVR (3.6+/-0.7 vs. 2.1+/-0.9 Woods units; p=0.02) and slope of mPAP-LVCO (5.8+/-2.4 vs. 2.9+/-2.1mmHg/L/min; p<0.0001). After adjustment for age and gender, exercise LAP (beta=3.1+/-0.8; p=0.001) and exercise PVR (beta=7.9+/-1.7; p=0.0001) were independent determinants of exercise sPAP. CONCLUSION: EIPH is frequent in SSc patients and is mainly related to both increased exercise LV filling pressure and exercise PVR. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailRating Network Paths for Locality-Aware Overlay Construction and Routing
Du, Wei; Liao, Yongjun ULg; Tao, Narisu et al

in IEEE/ACM Transactions on Networking (2014)

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse ... [more ▼]

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse-grained ratings are appealing in that they are not only informative but also cheap to obtain. Motivated by this insight, we firstly address the scalable acquisition of path ratings by statistical inference. By observing similarities to recommender systems, we examine the applicability of solutions to recommender system and show that our inference problem can be solved by a class of matrix factorization techniques. A technical contribution is an active and progressive inference framework that not only improves the accuracy by selectively measuring more informative paths but also speeds up the convergence for available bandwidth by incorporating its measurement methodology. Then, we investigate the usability of rating-based network measurement and inference in applications. A case study is performed on whether locality awareness can be achieved for overlay networks of Pastry and BitTorrent using inferred ratings. We show that such coarse-grained knowledge can improve the performance of peer selection and that finer granularities do not always lead to larger improvements. [less ▲]

Detailed reference viewed: 16 (4 ULg)
Full Text
Peer Reviewed
See detailEffect of fuel and kiln type on the polycyclic aromatic hydrocarbon (PAH) levels in smoked shrimp, a Beninese food condiment
Kpoclou, Euloge; Anihouvi, Victor; Azokpota, Paulin et al

in Food Additives & Contaminants. Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment (2014), 31(7), 1212-1218

Detailed reference viewed: 21 (14 ULg)
Full Text
Peer Reviewed
See detailLe « trouble » de l’éjaculation précoce : Le critère d’une minute maximum de pénétration en question
Kempeneers, Philippe ULg; Desseilles, Martin ULg

in Sexologies : Revue Européenne de Santé Sexuelle = European Journal of Sexual Health (2014), 23

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio ... [more ▼]

The current trend is to reserve the diagnosis of premature ejaculation (PE) for cases where penetration lasts for about one minute or less. The rationale is that the aetiology is primarily bio-constitutional, and that long-term pharmacological treatment is the only viable option. However, the literature contains little scientific evidence to support this argument. In fact, a good number of individuals who suffer from overly rapid ejaculation present with penetration duration exceeding one minute, and even severe forms of PE have responded favourably to psycho-sexological treatment. Moreover, although certain biological variables are known to influence ejaculation latency time, nothing indicates that they play an exclusive role of psychosocial etiological factors in severe PE. Therefore, it would be ‘premature’ to base a PE diagnosis on a maximum penetration duration of one minute, which should instead be considered a severity gradient. Given that desired criteria for penetration duration often exceed biological norms, it would be inappropriate to propose that only the most severe forms of PE have constitutional origins. In any case, the constitution is relatively flexible, and can respond to adaptive learning. An adaptive learning approach would undoubtedly be more difficult to apply in severe cases, but not impossible. The issue of whether to use pharmacological versus psycho-sexological treatment could be side-stepped by moving beyond the single criterion of ejaculation latency. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailStructural, magnetic and magneto-transport properties of monovalent doped manganite Pr0.55K0.05Sr0.4MnO3
Thaljaoui, R.; Boujelben, W.; Pękała, M. et al

in Journal of Alloys and Compounds (2014), 611(0), 427-432

Pr0.55K0.05Sr0.4MnO3 sample have been synthesized using the conventional solid state reaction. Rietveld refinements of the X-ray diffraction patterns at room temperature confirm that the sample is single ... [more ▼]

Pr0.55K0.05Sr0.4MnO3 sample have been synthesized using the conventional solid state reaction. Rietveld refinements of the X-ray diffraction patterns at room temperature confirm that the sample is single phase and crystallizes in the orthorhombic structure with Pnma space group; the crystallite size is around 70 nm. The SEM images show that grain size spreads around 1000–1200 nm. DTA analysis does not reveal any clear transition in temperature range studied. The low-temperature DSC indicates that Curie temperature is around 297 K. Magnetization measurements in a magnetic applied field of 0.01 T exhibit a paramagnetic–ferromagnetic transition at the Curie temperature TC = 303 K. A magnetic entropy change under an applied magnetic field of 2 T is found to be 2.26 J kg−1 K−1, resulting in a large relative cooling power around 70 J/kg. Electrical resistivity measurements reveal a transition from semiconductor to metallic phase. The thermal conductivity is found to be higher than that reported for undoped and Na doped manganites reported by Thaljaoui et al. (2013). [less ▲]

Detailed reference viewed: 15 (8 ULg)
Full Text
Peer Reviewed
See detailAUTOMATISATION DE LA DÉTECTION DES CRATÈRES LUNAIRES SUR DES IMAGES ET MNT PLANÉTAIRES
Renson, Pierre; Poncelet, Nadia; Vandeloise, Yannick et al

in Bulletin de la Société Géographique de Liège (2014), 61

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images ... [more ▼]

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images and DTM). In this context, the automation of the process is essential because the craters represent a landing risk and landmarks for visual navigation. It is also the key challenge because it is difficult to develop high level automatic processing comparable to the thinking carried out in a traditional visual interpretation. Our method automatically establishes a semantic diagnosis based on the combination of crater descriptors computed on the planetary products used. Finally, this application is part of a decision support tool and an assessment system of landing and mission survival risks. It also aims to feed a landmarks database for automatic visual navigation of a lunar landing spacecraft. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailMitochondrial encephalomyopathy with cytochrome c oxidase deficiency caused by a novel mutation in the MTCO1 gene.
Debray, François-Guillaume ULg; Seneca, Sara; Gonce, Michel et al

in Mitochondrion (2014)

Cytochrome c oxidase (COX) deficiency is one of the most common respiratory chain deficiencies. A woman was presented at the age of 18y with acute loss of consciousness, non-convulsive status epilepticus ... [more ▼]

Cytochrome c oxidase (COX) deficiency is one of the most common respiratory chain deficiencies. A woman was presented at the age of 18y with acute loss of consciousness, non-convulsive status epilepticus, slow neurological deterioration, transient cortical blindness, exercise intolerance, muscle weakness, hearing loss, cataract and cognitive decline. Muscle biopsy revealed ragged-red fibers, COX negative fibers and a significant decreased activity of complex IV in a homogenate. Using next generation massive parallel sequencing of the mtDNA, a novel heteroplasmic mutation was identified in MTCO1, m.7402delC, causing frameshift and a premature termination codon. Single fiber PCR showed co-segregation of high mutant load in COX negative fibers. Mutation in mitochondrially encoded complex IV subunits should be considered in mitochondrial encephalomyopathies and COX negative fibers after the common mtDNA mutations have been excluded. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailIdentification of 1-methyloctyl butanoate as the major sex pheromone component from females of the saddle gall midge, Haplodiplosis marginata (Diptera: Cecidomyiidae)
Censier, Florence ULg; Fischer, Christophe ULg; Pascal, Laurent et al

in Chemoecology (2014)

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective monitoring tool of saddle gall midge flights is needed in order to understand the enigmatic population dynamics of this pest, and to design an integrated management strategy. Therefore, volatile compounds emitted by females (alkan-2-ols and alk-2-yl butanoates) were identified, and the chirality of the emitted esters was determined to be the R absolute configuration. In field-trapping experiments, racemic non-2-yl butanoate attracted substantial numbers of H. marginata males. Thus, this compound will be useful in baited traps for monitoring seasonal flight patterns, and improving integrated management of the saddle gall midge in agricultural systems. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailSystème à tous les étages
Badir, Sémir ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2014), 4/2013

Detailed reference viewed: 8 (0 ULg)
Full Text
See detailUn monde entre accélération et incertitudes
Santander, Sébastian ULg

in Interventions Economiques = Papers in Political Economy (2014)

Detailed reference viewed: 27 (5 ULg)
Full Text
Peer Reviewed
See detailLA RADIOTHÉRAPIE MODERNE PRÉ- OU POSTOPERATOIRE POUR LES SARCOMES DES TISSUS MOUS DES MEMBRES
COUCKE, Philippe ULg; JANVARY, Zsolt Levente ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 53-57

Les sarcomes des tissus mous sont des cancers rares qui nécessitent une approche multidisciplinaire, au niveau diagnostique et en ce qui concerne le traitement et le suivi. La chirurgie (exérèse tumorale ... [more ▼]

Les sarcomes des tissus mous sont des cancers rares qui nécessitent une approche multidisciplinaire, au niveau diagnostique et en ce qui concerne le traitement et le suivi. La chirurgie (exérèse tumorale large en marges saines) est la base du traitement. Le risque de récidive étant élevé pour cer - tains sous-groupes de patients, une radiothérapie adjuvante est le plus souvent préconisée. Classiquement, ce traitement était donné en postopératoire, mais une radiothérapie pré - opératoire, dite «néo-adjuvante», offre un certain nombre d’avantages. Nous discutons également l’adaptation de la radiothérapie à la chirurgie et vice versa, ainsi que le parcours classique d’un patient traité pour un sarcome des tissus mous. Finalement, quelques évolutions techniques futures sont briè - vement présentées. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailNew role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline ULg; Renert, Anne-Françoise; Merville, Marie-Paule ULg et al

in Autophagy (2014)

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]

Detailed reference viewed: 95 (18 ULg)
Full Text
Peer Reviewed
See detailRobot-assisted laparoscopy for deep infiltrating endometriosis: international multicentric retrospective study.
Collinet, Pierre; Leguevaque, Pierre; Neme, Rosa Maria et al

in Surgical Endoscopy (2014), sous presse

BACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April ... [more ▼]

BACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April 2012, 164 women with stage 4 endometriosis who underwent robot-assisted laparoscopy (da Vinci Intuitive Surgical System) were included by to eight international participating clinical centers. This study evaluated the procedures performed, the duration of the intervention, the complications, the recurrence, and the impact on fertility. RESULTS: The average operative time was 180 min. The main complications were laparotomy (n = 1, 0.6 %), sutured bowel injury (n = 2, 1.2 %), transfusion for a 2,300-ml bleed (n = 1), prolonged urinary catheterization (n = 1, 0.6 %), ureter-bladder anastomotic leak (n = 1, 0.6 %), and ureteral fistula after ureterolysis (n = 2, 1.2 %). The reoperation rate was 1.8 % (n = 3). The mean follow-up period was 10.2 months. A full recovery was experienced by 86.7 % (98/113) of the patients. After surgery, 41.2 % (42/102) of the patients had a desire for pregnancy, and 28.2 % (11/39) of them became pregnant. CONCLUSION: This study analyzed the largest series of robot-assisted laparoscopies for deep infiltrating endometriosis published in the literature. No increase in surgical time, blood loss, or intra- or postoperative complications was observed. The interest in robot-assisted laparoscopy for deep infiltrating endometriosis seems to be promising. [less ▲]

Detailed reference viewed: 14 (5 ULg)
Full Text
Peer Reviewed
See detailmiRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization.
Valencia, Karmele; Luis-Ravelo, Diego; Bovy, Nicolas ULg et al

in Molecular oncology (2014), 8(3), 689-703

Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a ... [more ▼]

Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a process which entails reciprocal exchange of soluble signals between tumor cells and their osseous microenvironment. Recent evidence indicates that tumor-intrinsic miRNAs are pleiotropic regulators of gene expression. But they are also frequently released in exosome-like vesicles (ELV). Yet the functional relevance of the transference of tumor-derived ELV and their miRNA cargo to the extracellular milieu during osseous colonization is unknown. Comparative transcriptomic profiling using an in vivo murine model of bone metastasis identified a repressed miRNA signature associated with high prometastatic activity. Forced expression of single miRNAs identified miR-192 that markedly appeased osseous metastasis in vivo, as shown by X-ray, bioluminescence imaging and microCT scans. Histological examination of metastatic lesions revealed impaired tumor-induced angiogenesis in vivo, an effect that was associated in vitro with decreased hallmarks of angiogenesis. Isolation and characterization of ELV by flow cytometry, Western blot analysis, transmission electron microscopy and nanoparticle tracking analysis revealed the ELV cargo enrichment in miR-192. Consistent with these findings, fluorescent labeled miR-192-enriched-ELV showed the in vitro transfer and release of miR-192 in target endothelial cells and abrogation of the angiogenic program by repression of proangiogenic IL-8, ICAM and CXCL1. Moreover, in vivo infusion of fluorescent labeled ELV efficiently targeted cells of the osseous compartment. Furthermore, treatment with miR-192 enriched ELV in a model of in vivo bone metastasis pre-conditioned osseous milieu and impaired tumor-induced angiogenesis, thereby reducing the metastatic burden and tumor colonization. Changes in the miRNA-cargo content within ELV represent a novel mechanism heavily influencing bone metastatic colonization, which is most likely relevant in other target organs. Mechanistic mimicry of this phenomenon by synthetic nanoparticles could eventually emerge as a novel therapeutic approach. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailMary Anning’s legacy to French vertebrate palaeontology
Vincent, Peggy; Taquet, Philippe; Fischer, Valentin ULg et al

in Geological Magazine (2014), 151(1), 7-20

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent ... [more ▼]

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent study by eminent English and French scientists. In 1820, Georges Cuvier acquired several ichthyosaur specimens found by Mary Anning, now kept or displayed in the Palaeontology Gallery of the MNHN in Paris. Four years later, Cuvier obtained a plesiosaur specimen from Mary Anning, only the second ever discovered. Cuvier was fascinated by these fossils and their study allowed him to apply his comparative anatomical method and to support his catastrophist theory. We re-examined these important specimens from an historical point of view and herein describe them taxonomically for the first time since Cuvier’s works. The Paris specimens belong to two different ichthyosaur genera (Ichthyosaurus and Leptonectes) and one plesiosaur genus (Plesiosaurus). [less ▲]

Detailed reference viewed: 151 (4 ULg)
Full Text
Peer Reviewed
See detailIsocinétisme et douleurs musculaires d’apparition retardée
Hody, Stéphanie ULg; ROGISTER, Bernard ULg; Leprince, Pierre ULg et al

in Movement & Sport Sciences - Science & Motricité (2014)

The curative and preventive efficiency of the isokinetic exercise, especially of the eccentric contraction, has been well demonstrated. However, intense or unusual eccentric exercise is known to induce ... [more ▼]

The curative and preventive efficiency of the isokinetic exercise, especially of the eccentric contraction, has been well demonstrated. However, intense or unusual eccentric exercise is known to induce muscle damage associated with delayed-onset muscle soreness (DOMS) and prolonged functional deficits. These negative consequences can frequently disturb the progress of re-education or training programmes. Since they can affect athletic performance and increase the risk of musculo-skeletal injuries, the structuro-functional alterations associated with DOMS may also be problematic in athletes. Therefore, to optimize the benefits of the eccentric work while avoiding muscle damage and occurrence of DOMS should represent a major objective for the practitioners. To date, the only systematic intervention that brings muscle protection against DOMS consists of performing repeated eccentric sessions at submaximal intensity. Besides its clinical use, isokinetic constitutes an interesting model to generate and investigate the DOMS phenomenon. The original association of eccentric injuring protocols with new emerging techniques of molecular biology appears to be a promising strategy to better understand the cellular and molecular mechanisms underlying exercise-induced muscle damage. Such data would provide better guidelines for prevention or treatment practice. [less ▲]

Detailed reference viewed: 36 (12 ULg)
Full Text
Peer Reviewed
See detailPlatelet reactivity and cardiovascular events after percutaneous coronary intervention in patients with stable coronary artery disease: the Stent Thrombosis In Belgium (STIB) trial
LEGRAND, Victor ULg; CUISSET, T; CHENU, P et al

in EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2014), 10

PR measured before PCI in stable patients undergoing elective PCI who are preloaded with 500 mg of aspirin and 600 mg of clopidogrel is not predictive of periprocedural myocardial injury or adverse ... [more ▼]

PR measured before PCI in stable patients undergoing elective PCI who are preloaded with 500 mg of aspirin and 600 mg of clopidogrel is not predictive of periprocedural myocardial injury or adverse ischaemic complications up to 30 days. [less ▲]

Detailed reference viewed: 3 (1 ULg)
Full Text
Peer Reviewed
See detailLes effets du vieillissement normal et pathologique sur la cognition
Collette, Fabienne ULg; Salmon, Eric ULg

in Revue Médicale de Liège (2014), 69(5-6), 265-269

Des troubles cognitifs touchant principalement le fonctionnement exécutif et mnésique sont observés lors du vieillissement normal et de la maladie d’Alzheimer, et sont associés à des changements au niveau ... [more ▼]

Des troubles cognitifs touchant principalement le fonctionnement exécutif et mnésique sont observés lors du vieillissement normal et de la maladie d’Alzheimer, et sont associés à des changements au niveau de l’activité cérébrale. Il apparait toutefois que différents facteurs sont susceptibles de retarder la survenue des troubles cognitifs, tels que la stimulation mentale ou la pratique d’une activité physique. De même, les prises en charge cognitives permettent d’améliorer le fonctionnement au quotidien des patients présentant une maladie d’Alzheimer (MA). Identifier les facteurs et techniques qui contribuent à maintenir une vitalité cognitive et/ou à contrer les effets de la MA permettront d’optimiser la qualité de vie des seniors. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailLikelihood based inference for semi-competing risks
Heuchenne, Cédric ULg; Laurent, Stéphane ULg; Legrand, Catherine et al

in Communications in Statistics : Simulation & Computation (2014), 43(5), 1112-1132

Detailed reference viewed: 51 (5 ULg)
Full Text
Peer Reviewed
See detailJupiter's Magnetotail
Krupp, Norbert; Kronberg, Elena; Radioti, Aikaterini ULg

in AGU Monograph (2014)

Detailed reference viewed: 13 (4 ULg)
Full Text
Peer Reviewed
See detailMapping Diasporic Subjectivities
Munos, Delphine ULg; Pandurang, Mala

in South Asian Diaspora (2014), 6(1),

The last two decades have witnessed a growing interest in theorizing literary narratives that address the South Asian diasporic experience. By and large, however, what has emerged is an academic consensus ... [more ▼]

The last two decades have witnessed a growing interest in theorizing literary narratives that address the South Asian diasporic experience. By and large, however, what has emerged is an academic consensus which accords an ever-greater visibility to mainstream diasporic voices from North America, U.K., some parts of Africa and of the Caribbean, at the expense of narratives dealing with South Asian diasporic communities that are based in other locations. Also, such critical consensus valorizes certain class-streamed patterns of migration over others, with the result of homogenizing the diversity of today’s South Asian diaspora. This special issue explores literary representations of the migrant experiences of those underrepresented South Asian communities based in locations such as South America, East Europe, the Gulf, West Africa and East Asia. [less ▲]

Detailed reference viewed: 30 (6 ULg)
Full Text
Peer Reviewed
See detailUpdate of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance Certification Exam.
Petersen, Steffen E.; Almeida, Ana G.; Alpendurada, Francisco et al

in European heart journal cardiovascular Imaging (2014), 15(7), 728-729

An updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The ... [more ▼]

An updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The syllabus lists key elements of knowledge in CMR. It represents a framework for the development of training curricula and provides expected knowledge-based learning outcomes to the CMR trainees, in particular those intending to demonstrate CMR knowledge in the European CMR exam, a core requirement in the CMR certification process. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailA combinatorial branch-and-bound algorithm for box search
Mathieu, Sébastien ULg; Louveaux, Quentin ULg

in Discrete Optimization (2014), 13

Considering a set of points in a multi-dimensional space with an associated real value for each point, we want to find the box with the maximum sum of the values of the included points. This problem has ... [more ▼]

Considering a set of points in a multi-dimensional space with an associated real value for each point, we want to find the box with the maximum sum of the values of the included points. This problem has applications in data mining and can be formulated as a mixed-integer linear program. We propose a branch-and-bound algorithm where the bounding is obtained by combinatorial arguments instead of the traditional linear relaxation. Computational experiments show that this approach competes with current state of the art mixed-integer solvers. The algorithm proposed in this paper may be seen as a simple and dependence-free method to solve the box search problem. [less ▲]

Detailed reference viewed: 35 (16 ULg)
Full Text
Peer Reviewed
See detailEverolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial.
Andre, Fabrice; O'Regan, Ruth; Ozguroglu, Mustafa et al

in The lancet oncology (2014)

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to ... [more ▼]

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited women with HER2-positive, trastuzumab-resistant, advanced breast carcinoma who had previously received taxane therapy. Eligible patients were randomly assigned (1:1) using a central patient screening and randomisation system to daily everolimus (5 mg/day) plus weekly trastuzumab (2 mg/kg) and vinorelbine (25 mg/m2) or to placebo plus trastuzumab plus vinorelbine, in 3-week cycles, stratified by previous lapatinib use. The primary endpoint was progression-free survival (PFS) by local assessment in the intention-to-treat population. We report the final analysis for PFS; overall survival follow-up is still in progress. This trial is registered with ClinicalTrials.gov, number NCT01007942. FINDINGS: Between Oct 26, 2009, and May 23, 2012, 569 patients were randomly assigned to everolimus (n=284) or placebo (n=285). Median follow-up at the time of analysis was 20.2 months (IQR 15.0-27.1). Median PFS was 7.00 months (95% CI 6.74-8.18) with everolimus and 5.78 months (5.49-6.90) with placebo (hazard ratio 0.78 [95% CI 0.65-0.95]; p=0.0067). The most common grade 3-4 adverse events were neutropenia (204 [73%] of 280 patients in the everolimus group vs 175 [62%] of 282 patients in the placebo group), leucopenia (106 [38%] vs 82 [29%]), anaemia (53 [19%] vs 17 [6%]), febrile neutropenia (44 [16%] vs ten [4%]), stomatitis (37 [13%] vs four [1%]), and fatigue (34 [12%] vs 11 [4%]). Serious adverse events were reported in 117 (42%) patients in the everolimus group and 55 (20%) in the placebo group; two on-treatment deaths due to adverse events occurred in each group. INTERPRETATION: The addition of everolimus to trastuzumab plus vinorelbine significantly prolongs PFS in patients with trastuzumab-resistant and taxane-pretreated, HER2-positive, advanced breast cancer. The clinical benefit should be considered in the context of the adverse event profile in this population. FUNDING: Novartis Pharmaceuticals Corporation. [less ▲]

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailImpact of the invasive Asian clam, Corbicula spp., on a large river ecosytem
Pigneur, Lise-Marie; Falisse, Elodie; Roland, Kathleen et al

in Freshwater Biology (2014), 59(3), 573-583

During the past recent decades, Asiatic clams (Corbicula spp.) have spread spectacularly in several large European rivers. In the River Meuse, a transnational lowland river, an important chlorophyll a ... [more ▼]

During the past recent decades, Asiatic clams (Corbicula spp.) have spread spectacularly in several large European rivers. In the River Meuse, a transnational lowland river, an important chlorophyll a decline has been recorded since the mid-2000s, which seems to be related to the invasion by these exotic bivalves. This study aimed at verifying that hypothesis, using clam density data from field surveys, water quality monitoring data, and a simulation model. Estimated Corbicula densities were between 50 and 900 individuals m-2, depending on the site. Using a maximum filtration rate per clam body mass of 0.086 m3 g C-1 day-1 at 20°C derived from the literature, we ran simulations with a non-stationary model to estimate the impact of the exotic bivalve on the river plankton and water quality. In the stretches where the invasive clams developed best, comparison with a clam-free scenario allowed estimating a 70 % phytoplankton biomass loss due to their filtration, leading to a 61 % loss of annual primary productivity. Model simulations also showed that zooplankton may have suffered as much as 75 % loss in terms of biomass. The simulations also point to substantial effects of the invasive Corbicula on the river oxygen budget and on nutrient cycling. We expect that, in the heavily regulated sectors of the river, the loss of planktonic production due to the invasive filter-feeders will negatively affect other suspension feeders and alter ecosystem function and productivity. [less ▲]

Detailed reference viewed: 27 (4 ULg)
Full Text
Peer Reviewed
See detailLearning from our European imaging colleagues.
Weissman, Neil J.; Lancellotti, Patrizio ULg

in JACC. Cardiovascular imaging (2014), 7(6), 639-40

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailWhat factors determine Belgian general practitioners' approaches to detecting and managing substance abuse? A qualitative study based on the I-Change Model.
Ketterer, Frédéric ULg; Symons, Linda; Lambrechts, Marie-Claire et al

in BMC Family Practice (2014), 15(1), 119

BACKGROUND: General practitioners (GPs) are considered to play a major role in detecting and managing substance abuse. However, little is known about how or why they decide to manage it. This study ... [more ▼]

BACKGROUND: General practitioners (GPs) are considered to play a major role in detecting and managing substance abuse. However, little is known about how or why they decide to manage it. This study investigated the factors that influence GP behaviours with regard to the abuse of alcohol, illegal drugs, hypnotics, and tranquilisers among working Belgians. METHODS: Twenty Belgian GPs were interviewed. De Vries' Integrated Change Model was used to guide the interviews and qualitative data analyses. RESULTS: GPs perceived higher levels of substance abuse in urban locations and among lower socioeconomic groups. Guidelines, if they existed, were primarily used in Flanders. Specific training was unevenly applied but considered useful. GPs who accepted abuse management cited strong interpersonal skills and available multidisciplinary networks as facilitators.GPs relied on their clinical common sense to detect abuse or initiate management. Specific patients' situations and their social, psychological, or professional dysfunctions were cited as cues to action.GPs were strongly influenced by their personal representations of abuse, which included the balance between their professional responsibilities toward their patients and the patients' responsibilities in managing their own health as well the GPs' abilities to cope with unsatisfying patient outcomes without reaching professional exhaustion. GPs perceived substance abuse along a continuum ranging from a chronic disease (whose management was part of their responsibility) to a moral failing of untrustworthy people. Alcohol and cannabis were more socially acceptable than other drugs. Personal experiences of emotional burdens (including those regarding substance abuse) increased feelings of empathy or rejection toward patients.Multidisciplinary practices and professional experiences were cited as important factors with regard to engaging GPs in substance abuse management. Time constraints and personal investments were cited as important barriers.Satisfaction with treatment was rare. CONCLUSIONS: Motivational factors, including subjective beliefs not supported by the literature, were central in deciding whether to manage cases of substance abuse. A lack of theoretical knowledge and training were secondary to personal attitudes and motivation. Personal development, emotional health, self-awareness, and self-care should be taught to and fostered among GPs to help them maintain a patient-centred focus. Health authorities should support collaborative care. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailAnalysis of the global atmospheric methane budget using ECHAM-MOZ simulations for present-day, pre-industrial time and the Last Glacial Maximum
Basu, A.; Schultz, M. G.; Schröder, S. et al

in Atmospheric Chemistry & Physics Discussions (2014), 14

Atmospheric methane concentrations increased considerably from pre-industrial (PI) to present times largely due to anthropogenic emissions. However, firn and ice core records also document a notable rise ... [more ▼]

Atmospheric methane concentrations increased considerably from pre-industrial (PI) to present times largely due to anthropogenic emissions. However, firn and ice core records also document a notable rise of methane levels between the Last Glacial Maximum (LGM) and the pre-industrial era, the exact cause of which is not entirely clear. This study investigates these changes by analyzing the methane sources and sinks at each of these climatic periods. Wetlands are the largest natural source of methane and play a key role in determining methane budget changes in particular in the absence of anthropogenic sources. Here, a simple wetland parameterization suitable for coarse-scale climate simulations over long periods is introduced, which is derived from a high- resolution map of surface slopes together with various soil hydrology parameters from the CARAIB vegetation model. This parameterization was implemented in the chem- istry general circulation model ECHAM5-MOZ and multi-year time slices were run for LGM, PI and present-day (PD) climate conditions. Global wetland emissions from our parameterization are 72 Tg yr [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailThe role of the youth in community forestry in Gabon
Boldrini, Sylvie; Meunier, Quentin; Gillet, Pauline ULg et al

in Nature et Faune (2014), 28(1), 56-59

In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus ... [more ▼]

In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus, communities however rarely integrate the youth (between the ages of 16 to 24) who reside permanently in the village in village associations. The youth are generally excluded from the decision making process of elders. In fact, the youth that reside permanently in the village do not generally hold any diploma and have no professional qualification. Consequently, they are hardly respected by the people around them and their opinions are not taken into account. They are left out of any activity conducted by the associations unless these activities are remunerated. However, the involvement of the youth in village associations is necessary, not only to increase the work capacity, but also to ensure the perpetuation of interventions since the youth will be the first and future beneficiaries of the community forest. [less ▲]

Detailed reference viewed: 70 (20 ULg)
Full Text
Peer Reviewed
See detailNi fantôme ni zombie. L'émergence de la conscience subjective dans le flux des expériences
Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(3), 1-28

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailRelationships between rapid changes in local aromatase activity and estradiol concentrations in male and female quail brain.
Dickens, M. J.; de Bournonville, C.; Balthazart, Jacques ULg et al

in Hormones and behavior (2014), 65(2), 154-164

Estradiol-17beta (E2) synthesized in the brain plays a critical role in the activation of sexual behavior in many vertebrate species. Because E2 concentrations depend on aromatization of testosterone ... [more ▼]

Estradiol-17beta (E2) synthesized in the brain plays a critical role in the activation of sexual behavior in many vertebrate species. Because E2 concentrations depend on aromatization of testosterone, changes in aromatase enzymatic activity (AA) are often utilized as a proxy to describe E2 concentrations. Utilizing two types of stimuli (sexual interactions and acute restraint stress) that have been demonstrated to reliably alter AA within minutes in opposite directions (sexual interactions=decrease, stress=increase), we tested in Japanese quail whether rapid changes in AA are paralleled by changes in E2 concentrations in discrete brain areas. In males, E2 in the pooled medial preoptic nucleus/medial portion of the bed nucleus of the stria terminalis (POM/BST) positively correlated with AA following sexual interactions. However, following acute stress, E2 decreased significantly (approximately 2-fold) in the male POM/BST despite a significant increase in AA. In females, AA positively correlated with E2 in both the POM/BST and mediobasal hypothalamus supporting a role for local, as opposed to ovarian, production regulating brain E2 concentrations. In addition, correlations of individual E2 in POM/BST and measurements of female sexual behavior suggested a role for local E2 synthesis in female receptivity. These data demonstrate that local E2 in the male brain changes in response to stimuli on a time course suggestive of potential non-genomic effects on brain and behavior. Overall, this study highlights the complex mechanisms regulating local E2 concentrations including rapid stimulus-driven changes in production and stress-induced changes in catabolism. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailLE MÉDICAMENT DU MOIS L’acétate d’ulipristal (Esmya®) : un modulateur sélectif des récepteurs à la progestérone, nouveau traitement de la fibromatose utérine
Nisolle, Michelle ULg; CLOSON, François ULg; FIRQUET, Anne ULg et al

in Revue Médicale de Liège (2014), 69(4), 220-225

Ulipristal acetate (Esmya®) : a selective modulator of progesterone receptors, new treatment of uterine fibromatosis Summary : Uterine fibromatosis is a frequent benign gynaecological disease causing ... [more ▼]

Ulipristal acetate (Esmya®) : a selective modulator of progesterone receptors, new treatment of uterine fibromatosis Summary : Uterine fibromatosis is a frequent benign gynaecological disease causing heavy menstrual bleeding and in some cases anaemia. Until now, medical treatment aimed to obtain amenorrhea by administration of progestins or Gn-RH agonists. By inducing hypo-oestrogenism, a reduction of myoma size is observed with Gn-RH agonists but after cessation of the treatment, initial myoma size is noted. The impact of progesterone in myoma growth is nowadays demonstrated and use of selective modulators of progesterone receptors represents a new medical approach of this disease. [less ▲]

Detailed reference viewed: 52 (12 ULg)
Full Text
Peer Reviewed
See detailDouble Objective Economic Statistical Design of the VPT2 Control Chart: Wald’s identity approach
Faraz, Alireza ULg; Heuchenne, Cédric ULg; Saniga, Erwin et al

in Journal of Statistical Computation & Simulation (2014), 84

Recent studies have shown that applying the control chart by using a variable parameters (VP) scheme yields more rapid detection of assignable causes than the classical method of taking fixed sample sizes ... [more ▼]

Recent studies have shown that applying the control chart by using a variable parameters (VP) scheme yields more rapid detection of assignable causes than the classical method of taking fixed sample sizes at fixed intervals of time. In this paper, the problem of economical statistical design of the VP T2 control chart is considered as a double-objective minimization problem with the statistical objective adjusted average time to signal and the economic objective expected cost per hour. Then we strive to find the Pareto-optimal designs in which the two objectives are met simultaneously by using a multi-objective Genetic Algorithm or GA. Through an illustrative example, we show that relatively large benefits accrue to the VP method relative to the classical policy; further another advantage of our approach is to provide a list of alternative solutions that can be explored graphically. This then ensures flexibility and adaptability, an important attribute of contemporary control chart design. [less ▲]

Detailed reference viewed: 54 (10 ULg)
Full Text
Peer Reviewed
See detailDorsomedial prefrontal metabolism and unawareness of current characteristics of personality traits in Alzheimer’s disease
Jedidi, Haroun ULg; Feyers, Dorothée ULg; Collette, Fabienne ULg et al

in Social Cognitive and Affective Neuroscience (2014)

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while ... [more ▼]

Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while unawareness of current characteristics of personality traits has rarely been considered. We used a well-established questionnaire-based method in a group of 37 AD patients and in healthy controls to probe self- and hetero-evaluation of patients’ personality and we calculated differential scores between each participant’s and his/her relative’s judgments. A brain-behavior correlation was performed using FDG-PET images. The behavioral data showed that AD patients presented with anosognosia for current characteristics of their personality and their anosognosia was primarily explained by impaired third perspective taking. The brain-behavior correlation analysis revealed a negative relationship between anosognosia for current characteristics of personality and dorsomedial prefrontal cortex (dMPFC) activity. Behavioral and neuroimaging data are consistent with the view that impairment of different functions subserved by the dMPFC (self-evaluation, inferences regarding complex enduring dispositions of self and others, confrontation of perspectives in interpersonal scripts) plays a role in anosognosia for current characteristics of personality in AD patients. [less ▲]

Detailed reference viewed: 34 (15 ULg)
Full Text
Peer Reviewed
See detailField veterinary survey on clinical and economic impact of Schmallenberg virus in Belgium
Martinelle, Ludovic ULg; Dal Pozzo, Fabiana ULg; Gauthier, B et al

in Transboundary and Emerging Diseases (2014), 61(3), 285-288

Detailed reference viewed: 43 (11 ULg)
Full Text
Peer Reviewed
See detailSpread of hatch and delayed feed access affect post hatch performance of female broiler chicks up to day 5.
Wang, Y.; Li, Yue; Willems, E. et al

in Animal (2014)

It is not rare that newly hatched chicks remain without feed for about 24 to 48 h before they are placed on farms due to a series of logistic operations. Furthermore, the spread in hatching time can also ... [more ▼]

It is not rare that newly hatched chicks remain without feed for about 24 to 48 h before they are placed on farms due to a series of logistic operations. Furthermore, the spread in hatching time can also mount up to 30 to 48 h for late v. early hatchers. In other words, the practice is a complex combination of spread of hatch and delayed feed access. The present study was aimed to investigate the combined effects of hatching time with a delay in feed access of 48 h, starting from their hatch-time (biological age). When chicks had access to feed immediately after hatch, late hatchers had a higher feed intake and relative growth rate up to day 5 compared with their early hatched counterparts. Feed deprivation during the first 48 h resulted in retarded early growth rate, which was further aggravated by an impaired feed intake after refeeding. In addition, the differential effects of hatching time on relative growth rate and feed intake observed in immediately fed chicks were eliminated by the 48 h feed delay. The yolk utilization after hatch was faster for the late hatchers up to biological day 2 regardless of the feeding treatments. Hatching muscle glycogen content was higher in the late hatchers compared with that of their early counterparts at hatch and at biological day 2 independent of feeding treatment. Moreover, the liver glycogen content of the late hatchers was also higher at hatch. For the immediately fed chicks, the proportional breast muscle weight of the late hatchers was higher at biological day 2 and 5. For the starved chicks, on the other hand, this effect was only observed after they had access to feed (biological day 5). The different plasma T3 levels at hatch may have contributed to the different post hatch performance. It is concluded that the spread of hatch influenced post hatch performance, especially appetite and growth at least until day 5. Moreover, the delay in feed access interacted with the hatching time and caused adverse effects on the post hatch performance. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailRomosozumab in Postmenopausal Women with Low Bone Mineral Density.
McClung, Michael R.; Grauer, Andreas; Boonen, Steven et al

in The New England journal of medicine (2014), 370

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. Methods In a phase 2, multicenter ... [more ▼]

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. Methods In a phase 2, multicenter, international, randomized, placebo-controlled, parallel-group, eight-group study, we evaluated the efficacy and safety of romosozumab over a 12-month period in 419 postmenopausal women, 55 to 85 years of age, who had low bone mineral density (a T score of -2.0 or less at the lumbar spine, total hip, or femoral neck and -3.5 or more at each of the three sites). Participants were randomly assigned to receive subcutaneous romosozumab monthly (at a dose of 70 mg, 140 mg, or 210 mg) or every 3 months (140 mg or 210 mg), subcutaneous placebo, or an open-label active comparator - oral alendronate (70 mg weekly) or subcutaneous teriparatide (20 mug daily). The primary end point was the percentage change from baseline in bone mineral density at the lumbar spine at 12 months. Secondary end points included percentage changes in bone mineral density at other sites and in markers of bone turnover. Results All dose levels of romosozumab were associated with significant increases in bone mineral density at the lumbar spine, including an increase of 11.3% with the 210-mg monthly dose, as compared with a decrease of 0.1% with placebo and increases of 4.1% with alendronate and 7.1% with teriparatide. Romosozumab was also associated with large increases in bone mineral density at the total hip and femoral neck, as well as transitory increases in bone-formation markers and sustained decreases in a bone-resorption marker. Except for mild, generally nonrecurring injection-site reactions with romosozumab, adverse events were similar among groups. Conclusions In postmenopausal women with low bone mass, romosozumab was associated with increased bone mineral density and bone formation and with decreased bone resorption. (Funded by Amgen and UCB Pharma; ClinicalTrials.gov number, NCT00896532 .). [less ▲]

Detailed reference viewed: 35 (6 ULg)
Full Text
Peer Reviewed
See detailEtude de la dynamique des populations d'insectes sur la culture du riz NERICA dans les conditions du Masuku, Sud-Est du Gabon (Franceville)
ONDO OVONO, Paul; GATARASI, Thaddée; OBAME MINKO, Daniel et al

in International Journal of Biological and Chemical Sciences (2014)

La dynamique des populations d’insectes sur la culture du riz a été étudiée durant toutes les phases de croissance. L’essai a été installé sur les parcelles pédagogiques de l’Institut National Supérieur ... [more ▼]

La dynamique des populations d’insectes sur la culture du riz a été étudiée durant toutes les phases de croissance. L’essai a été installé sur les parcelles pédagogiques de l’Institut National Supérieur d’Agronomie et de Biotechnologies à Franceville. Il s’inscrit dans le cadre de la poursuite des travaux d’évaluation de l’adaptabilité de nouvelles variétés de riz de type NERICA, introduites dans la province du Haut –Ogooué au Sud-Est du Gabon. L’objectif de la présente étude est de collecter des informations concernant les insectes susceptibles de s’attaquer au riz et de sélectionner les variétés NERICA qui résistent le mieux aux attaques. Chacune des six variétés de type NERICA (1, 4, 11, 12, 14 et 17) a été semée en utilisant un dispositif en blocs complètement randomisés avec trois répétitions, en 2010 et 2011. La collecte des insectes volants a été effectuée au moyen de pièges aériens et du filet entomologique. Au sol, la capture s’est faite au moyen de pièges. Les larves d’insectes foreurs des tiges, les chenilles et les pucerons des racines ont été capturés à la main. Au total, 46 familles appartenant à 9 ordres ont été recensées donc 29 renferment des espèces nuisibles et définies comme ravageuses du riz. Les 17 autres familles sont classées comme insectes utiles. Les stades de tallage, d’initiation paniculaire et d’épiaison ont été en général les plus visités par les différentes familles d’insectes. Les variétés NERICA 1 et NERICA 11 ont présenté les plus faibles taux d’infestation et de dégâts. Par ailleurs, la perte en biomasse a été considérable chez toutes les variétés. [less ▲]

Detailed reference viewed: 37 (3 ULg)
Full Text
Peer Reviewed
See detailA propos de l'encéphalopathie du nouveau-né
Battisti, Oreste ULg; Beguin, Yves ULg

in Percentile (2014)

editorial sur l'hypoxie périnatale et les cellules souches.

Detailed reference viewed: 36 (3 ULg)
Full Text
Peer Reviewed
See detailA Review of the Current Status of Laparoscopic and Robot-assisted Sacrocolpopexy for Pelvic Organ Prolapse.
Lee, Richard K.; Mottrie, Alexandre; Payne, Christopher K. et al

in European urology (2014), 65(6), 1128-1137

CONTEXT: Abdominal sacrocolpopexy (ASC) represents the superior treatment for apical pelvic organ prolapse (POP) but is associated with increased length of stay, analgesic requirement, and cost compared ... [more ▼]

CONTEXT: Abdominal sacrocolpopexy (ASC) represents the superior treatment for apical pelvic organ prolapse (POP) but is associated with increased length of stay, analgesic requirement, and cost compared with transvaginal procedures. Laparoscopic sacrocolpopexy (LSC) and robot-assisted sacrocolpopexy (RSC) may offer shorter postoperative recovery while maintaining equivalent rates of cure. OBJECTIVE: This review evaluates the literature on LSC and RSC for clinical outcomes and complications. EVIDENCE ACQUISITION: A PubMed search of the available literature from 1966 to 2013 on LSC and RSC with a follow-up of at least 12 mo was performed. A total of 256 articles were screened, 69 articles selected, and outcomes from 26 presented. A review, not meta-analysis, was conducted due to the quality of the articles. EVIDENCE SYNTHESIS: LSC has become a mature technique with results from 11 patient series encompassing 1221 patients with a mean follow-up of 26 mo. Mean operative time was 124min (range: 55-185) with a 3% (range: 0-11%) conversion rate. Objective cure was achieved in 91% of patients, with similar satisfaction rates (92%). Six patient series encompassing 363 patients treated with RSC with a mean follow-up of 28 mo have been reported. Mean operative time was 202min (range: 161-288) with a 1% (range: 0-4%) conversion rate. Objective cure rate was 94%, with a 95% subjective success rate. Overall, early outcomes and complication rates for both LSC and RSC appeared comparable with open ASC. CONCLUSIONS: LSC and RSC provide excellent short- to medium-term reconstructive outcomes for patients with POP. RSC is more expensive than LSC. Further studies are required to better understand the clinical performance of RSC versus LSC and confirm long-term efficacy. PATIENT SUMMARY: Laparoscopic and robot-assisted sacrocolpopexy represent attractive minimally invasive alternatives to abdominal sacrocolpopexy. They may offer reduced patient morbidity but are associated with higher costs. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailProtection of winter wheat against orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae): efficacy of insecticides and cultivar resistance
Chavalle, Sandrine; Censier, Florence ULg; De Proft, Michel et al

in Pest Management Science (2014)

BACKGROUND: In 2012 and 2013, Sitodiplosis mosellana (Géhin) flights occurred during the susceptible phase of wheat development in Belgium. The protection against this midge afforded by various ... [more ▼]

BACKGROUND: In 2012 and 2013, Sitodiplosis mosellana (Géhin) flights occurred during the susceptible phase of wheat development in Belgium. The protection against this midge afforded by various insecticides was assessed in infested fields on four winter wheat cultivars (susceptible or resistant, and early or late heading). RESULTS: The insecticides sprayed at the right time reduced the number of larvae in the ears by 44-96%, depending on the product. For Julius, the cultivar (cv.) most exposed to S. mosellana in 2013, the mean yield gain resulting from insecticide use was 1,558 kg ha-1 (18%). In the same year, insecticide use resulted in a yield gain of 780 kg ha-1 (8%) for the cv. Lear, despite its resistance to this pest. The link between yield and number of larvae counted in the ears was a logarithmic relationship, suggesting an important reduction in yield caused either by the damage inflicted by young larvae which died at the start of their development or by the activation of costly reactions in plants. CONCLUSION: The study showed that, in cases of severe attack, the timely application of insecticide treatments can protect wheat against S. mosellana and that even resistant cultivars can benefit from these treatments. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailDeltaNp63 isoform-mediated beta-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma.
Suarez-Carmona, Meggy ULg; Hubert, Pascale ULg; Gonzalez, Arnaud ULg et al

in Oncotarget (2014), sous presse

Beside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype ... [more ▼]

Beside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype in tumorigenesis is still confusing. Constitutively produced or induced in inflammatory conditions, human beta-defensins (HbetaDs) are cationic peptides involved in host defenses against bacteria, viruses and fungi. Here, we investigated both the role of p63 proteins in the regulation of HbetaDs and the implication of these antimicrobial peptides in tumor (lymph)angiogenesis. Thus, in contrast to TAp63 isotypes, we observed that DeltaNp63 proteins (alpha, beta, gamma) induce HbetaD1, 2 and 4 expression. Similar results were observed in cancer tissues and cell lines. We next demonstrated that DeltaNp63-overexpressing SCC are associated with both a poor prognosis and a high tumor vascularisation and lymphangiogenesis. Moreover, we showed that HbetaDs exert a chemotactic activity for (lymphatic) endothelial cells in a CCR6-dependent manner. The ability of HbetaDs to enhance (lymph)angiogenesis in vivo was also evaluated. We observed that HbetaDs increase the vessel number and induce a significant increase in relative vascular area compared to negative control. Taken together, the results of this study suggest that DeltaNp63-regulated HbetaD could promote tumor (lymph)angiogenesis in SCC microenvironment. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailComplex dynamics of a nonlinear aerospace structure: experimental identification and modal interactions
Noël, Jean-Philippe ULg; Renson, Ludovic ULg; Kerschen, Gaëtan ULg

in Journal of Sound & Vibration (2014), 333

Nonlinear system identification is a challenging task in view of the complexity and wide variety of nonlinear phenomena. The present paper addresses the identification of a real-life aerospace structure ... [more ▼]

Nonlinear system identification is a challenging task in view of the complexity and wide variety of nonlinear phenomena. The present paper addresses the identification of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. The complete identification procedure, from nonlinearity detection and characterization to parameter estimation, is carried out based upon experimental data. The combined use of various analysis techniques, such as the wavelet transform and the restoring force surface method, brings different perspectives to the dynamics. Specifically, the structure is shown to exhibit particularly interesting nonlinear behaviors, including jumps, modal interactions, force relaxation and chattering during impacts on the mechanical stops. [less ▲]

Detailed reference viewed: 43 (15 ULg)
Full Text
Peer Reviewed
See detailEvidence for an own-age bias in age estimation from voices in older persons
Moyse, Evelyne ULg; Beaufort, Aline ULg; Brédart, Serge ULg

in European Journal of Ageing (2014)

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the ... [more ▼]

Previous studies have investigated the effect of ageing on age estimation from faces as well as the occur- rence of an own-age bias in such age estimation from faces. To the best of our knowledge, the occurrence of an own age effect on age estimation from voices has never been examined earlier using an experimental design in which the age of participants (young vs. old) and the age of voice stimuli (young vs. old) were crossed. Results revealed an own-age bias in older adults only. In comparison with younger adults, older participants showed age estimation abilities that are preserved for voices from their own age group and impaired for younger voices. This own age bias was absent in younger participants. [less ▲]

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detaildivand-1.0: n-dimensional variational data analysis for ocean observations
Barth, Alexander ULg; Beckers, Jean-Marie ULg; Troupin, Charles ULg et al

in Geoscientific Model Development (2014), 7

A tool for multidimensional variational analysis (divand) is presented. It allows the interpolation and analysis of observations on curvilinear orthogonal grids in an arbitrary high dimensional space by ... [more ▼]

A tool for multidimensional variational analysis (divand) is presented. It allows the interpolation and analysis of observations on curvilinear orthogonal grids in an arbitrary high dimensional space by minimizing a cost function. This cost function penalizes the deviation from the observations, the deviation from a first guess and abruptly varying fields based on a given correlation length (potentially varying in space and time). Additional constraints can be added to this cost function such as an advection constraint which forces the analysed field to align with the ocean current. The method decouples naturally disconnected areas based on topography and topology. This is useful in oceanography where disconnected water masses often have different physical properties. Individual elements of the a priori and a posteriori error covariance matrix can also be computed, in particular expected error variances of the analysis. A multidimensional approach (as opposed to stacking 2-dimensional analysis) has the benefit of providing a smooth analysis in all dimensions, although the computational cost is increased. Primal (problem solved in the grid space) and dual formulations (problem solved in the observational space) are implemented using either direct solvers (based on Cholesky factorization) or iterative solvers (conjugate gradient method). In most applications the primal formulation with the direct solver is the fastest, especially if an a posteriori error estimate is needed. However, for correlated observation errors the dual formulation with an iterative solver is more efficient. The method is tested by using pseudo observations from a global model. The distribution of the observations is based on the position of the ARGO floats. The benefit of the 3-dimensional analysis (longitude, latitude and time) compared to 2-dimensional analysis (longitude and latitude) and the role of the advection constraint are highlighted. The tool divand is free software, and is distributed under the terms of the GPL license (http://modb.oce.ulg.ac.be/mediawiki/index.php/divand). [less ▲]

Detailed reference viewed: 99 (10 ULg)
Full Text
Peer Reviewed
See detailUse of Time- and Frequency-Domain Approaches for Damage Detection in Civil Engineering Structures
Nguyen, Viet Ha; Mahowald, Jean; Maas, Stefan et al

in Shock and Vibration (2014), 2014

The aim of this paper is to apply both time- and frequency-domain-based approaches on real-life civil engineering structures and to assess their capability for damage detection. The methodology is based ... [more ▼]

The aim of this paper is to apply both time- and frequency-domain-based approaches on real-life civil engineering structures and to assess their capability for damage detection. The methodology is based on Principal Component Analysis of the Hankel matrix built from output-only measurements and of Frequency Response Functions. Damage detection is performed using the concept of subspace angles between a current (possibly damaged state) and a reference (undamaged) state. The first structure is the Champangshiehl Bridge located in Luxembourg. Several damage levels were intentionally created by cutting a growing number of prestressed tendons and vibration data were acquired by the University of Luxembourg for each damaged state. The second example consists in reinforced and prestressed concrete panels. Successive damages were introduced in the panels by loading heavy weights and by cutting steel wires. The illustrations show different consequences in damage identification by the considered techniques. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailCardiovascular safety of strontium ranelate: real-life assessment in clinical practice.
Donneau, Anne-Françoise ULg; Reginster, Jean-Yves ULg

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Detailed reference viewed: 23 (14 ULg)
Full Text
Peer Reviewed
See detailVitamin D status and bone mineral density changes during alendronate treatment in postmenopausal osteoporosis.
Roux, Christian; Binkley, Neil; Boonen, Steven et al

in Calcified tissue international (2014), 94(2), 153-7

Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed ... [more ▼]

Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by 6 months and increasing spine and hip bone mineral density (BMD) after 1 year than SC. This post hoc analysis examined the relationship between BMD gain and 25(OH)D in women in SC receiving alendronate (SC/ALN, n = 134, 52% of the SC group) and in the ALN/D group (n = 257). At baseline, participants were of mean age 73 years and 72% were Caucasian, with a mean 25(OH)D of 14.9 ng/mL. In the SC/ALN group, most received vitamin D, although intake of vitamin D varied extensively (51% received <400 mug/day). In this group, end-of-study 25(OH)D correlated positively with mean percent increases from baseline in lumbar spine and femoral neck BMD [Pearson correlation coefficients (95% CI) = 0.23 (0.02-0.41) and 0.24 (0.03-0.41), respectively]. Baseline 25(OH)D correlated with increases in only lumbar spine BMD [Pearson correlation coefficient (95% CI) = 0.22 (0.01-0.40)]. No correlations between mean BMD change and 25(OH)D were seen with ALN/D. In conclusion, in postmenopausal women with osteoporosis and low 25(OH)D receiving alendronate and a wide range of vitamin D doses, the increase in lumbar spine and femoral neck BMD was positively correlated with serum 25(OH)D achieved by the end of the study and, to some extent, with 25(OH)D concentrations at baseline. The degree of success of alendronate therapy for osteoporosis may depend on the vitamin D status of patients. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailVaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.
Gutierrez, Geronimo; Rodriguez, Sabrina M.; De Brogniez, Alix ULg et al

in Viruses (2014), 6(6), 2416-2427

Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly ... [more ▼]

Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailMagnetocaloric effect of monovalent K doped manganites Pr0.6Sr0.4−xKxMnO3 (x=0 to 0.2)
Thaljaoui, R.; Boujelben, W.; Pękała, M. et al

in Journal of Magnetism and Magnetic Materials (2014), 352(0), 6-12

Magnetic and magnetocaloric properties are reported for polycrystalline monovalent potassium doped manganites Pr0.6Sr0.4−xKxMnO3 (x=0, 0.05, 0.1, 0.15 and 0.2) crystallized in orthorhombic structure with ... [more ▼]

Magnetic and magnetocaloric properties are reported for polycrystalline monovalent potassium doped manganites Pr0.6Sr0.4−xKxMnO3 (x=0, 0.05, 0.1, 0.15 and 0.2) crystallized in orthorhombic structure with Pnma space group. The increasing K content shifts the paramagnetic to ferromagnetic transition temperature from 310 K for x=0 to 269 K for x=0.2. The magnetic entropy change under magnetic field variation of 2 T is found to be 1.95, 3.09, 2.89, 3.05 and 3.2 J/kgK for x varying from 0 to 0.2, respectively. The highest relative cooling power of 102 J/kg is observed for the undoped sample. The sensitivity of magnetic entropy change to magnetic field is estimated by a local N(T) exponent exhibiting the characteristic temperature variation. Phenomenological universal curves of entropy change and Arrott plots confirm the second order phase transition. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailLe point de rosée en berne et la couche cornée hivernale.
PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg; Delvenne, Philippe ULg

in Revue Médicale de Liège (2014), 69(2), 68-71

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed ... [more ▼]

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy. Keywords : Stratum corneum - Dew point [less ▲]

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detailCusp observation at Saturn’s high-latitude magnetosphere by the Cassini spacecraft
Jasinski; Arridge; Lamy et al

in Geophysical Research Letters (2014)

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailFunctionalization of carbon xerogels for the preparation of palladium supported catalysts applied in sugar transformations
Mager, Nathalie; Meyer, Nathalie; Léonard, Alexandre ULg et al

in Applied Catalysis B : Environmental (2014), 148-149

Detailed reference viewed: 40 (5 ULg)
Full Text
See detailEnergies et minerais.Des ressources sous tension
Merenne-Schoumaker, Bernadette ULg

in La Documentation Photographique (2014), 8089

Les ressources non renouvelables sont sans conteste une clé de lecture de notre monde contemporain, de ses tensions et de ses défis. Ces ressources sont « sous tension » car leur demande est en forte ... [more ▼]

Les ressources non renouvelables sont sans conteste une clé de lecture de notre monde contemporain, de ses tensions et de ses défis. Ces ressources sont « sous tension » car leur demande est en forte croissance. Leur géopolitique ne cesse d’évoluer. Ainsi, le pétrole et le gaz de schiste américains bouleversent les équilibres mondiaux, alors que le charbon fait un retour en force. L’enjeu est aussi environnemental et sociétal. [less ▲]

Detailed reference viewed: 60 (5 ULg)
Full Text
Peer Reviewed
See detailThe tumbling spin state of (99942) Apophis
Pravec, P; Scheirich, P; Ďurech, J et al

in Icarus (2014), 233

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailDUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
Amand, Mathieu ULg; Erpicum, Charlotte ULg; BAJOU, Khalid ULg et al

in Molecular Cancer (2014)

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies ... [more ▼]

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, DUSP3 is implicated in human cancer. It has been alternatively described as having tumor suppressive and oncogenic properties. Thus, the available data suggest that DUSP3 plays complex and contradictory roles in tumorigenesis that could be cell type-dependent. Since most of these studies were performed using recombinant proteins or in cell-transfection based assays, the physiological function of DUSP3 has remained elusive. Results Using immunohistochemistry on human cervical sections, we observed a strong expression of DUSP3 in endothelial cells (EC) suggesting a contribution for this phosphatase to EC functions. DUSP3 downregulation, using RNA interference, in human EC reduced significantly in vitro tube formation on Matrigel and spheroid angiogenic sprouting. However, this defect was not associated with an altered phosphorylation of the documented in vitro DUSP3 substrates, ERK1/2, JNK1/2 and EGFR but was associated with an increased PKC phosphorylation. To investigate the physiological function of DUSP3, we generated Dusp3-deficient mice by homologous recombination. The obtained DUSP3-/- mice were healthy, fertile, with no spontaneous phenotype and no vascular defect. However, DUSP3 deficiency prevented neo-vascularization of transplanted b-FGF containing Matrigel and LLC xenograft tumors as evidenced by hemoglobin (Hb) and FITC-dextran quantifications. Furthermore, we found that DUSP3 is required for b-FGF-induced microvessel outgrowth in the aortic ring assay. Conclusions All together, our data identify DUSP3 as a new important player in angiogenesis. [less ▲]

Detailed reference viewed: 22 (9 ULg)
Full Text
Peer Reviewed
See detailSpatial Planning as a driver of change in mobility and residential energy consumption
Dujardin, Sébastien; Marique, Anne-Françoise ULg; Teller, Jacques ULg

in Energy & Buildings (2014), 68

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning ... [more ▼]

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning decisions upon energy consumption in both residential building stock and home-to-work commuting. The analysis has been conducted on a regional scale (16,844 km2) and includes urban, peri-urban and rural settlements. Those settlements that perform well in mobility also appear to perform well in terms of building energy consumption. Even though this is not generally the case, it further reveals that some rural settlements characterized by low density show good performance in terms of energy efficiency. This permits a much more progressive approach in terms of spatial planning, whereby compact cities may be viewed as part of the solution, albeit not the whole solution. [less ▲]

Detailed reference viewed: 129 (58 ULg)
Full Text
Peer Reviewed
See detailWeighing Elephants with Kitchen Scales. The relevance of traditional performance measurement tools for social enterprises
Mouchamps, Hugues ULg

in International Journal of Productivity & Performance Management (2014), 63(6), 727-745

Purpose – The purpose of this paper is to analyze whether the use of current performance tools is consistent with the specific features of social enterprises. Design/methodology/approach – In a first ... [more ▼]

Purpose – The purpose of this paper is to analyze whether the use of current performance tools is consistent with the specific features of social enterprises. Design/methodology/approach – In a first phase, the main performance tools are divided into strategic planning tools, reporting tools and economic optimization techniques. In a second phase, 15 criteria emerge from a literature review to characterize the specific features of social enterprises. These criteria are brought together into an analytical framework, which makes it possible to analyze the relevance of each performance tool in relation to the specific features of social enterprises. Findings – What comes out of the analysis is that the tools globally fail to account for the specific features of social enterprises. That none of them met more than half of the criteria suggests the need for new performance tools based on strong theoretical bases. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailFirst Principles Explanation of the Positive Seebeck Coefficient of Lithium
Xu, Bin ULg; Verstraete, Matthieu ULg

in Physical Review Letters (2014), 112

Detailed reference viewed: 23 (3 ULg)
Full Text
Peer Reviewed
See detailA Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish
Genon, Sarah ULg; Bastin, Christine ULg; Angel, Lucie et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 54

Detailed reference viewed: 52 (11 ULg)
Full Text
Peer Reviewed
See detailAdequate iron chelation therapy for at least six months improves survival in transfusion-dependent patients wih lower risk myelodysplastic syndromes
Delforge, Michel; Selleslag, Dominik; BEGUIN, Yves ULg et al

in Leukemia Research (2014), 38

Background: Most patients with myelodysplastic syndromes (MDS) require transfusions at the risk of ironoverload and associated organ damage, and death. Emerging evidence indicates that iron chelation ther ... [more ▼]

Background: Most patients with myelodysplastic syndromes (MDS) require transfusions at the risk of ironoverload and associated organ damage, and death. Emerging evidence indicates that iron chelation ther-apy (ICT) could reduce mortality and improve survival in transfusion-dependent MDS patients, especiallythose classified as International Prognostic Scoring System (IPSS) Low or Intermediate-1 (Low/Int-1).Methods: Follow-up of a retrospective study. Sample included 127 Low/Int-1 MDS patients from 28 centersin Belgium. Statistical analysis stratified by duration (≥6 versus <6 months) and quality of chelation (adequate versus weak). Results: Crude chelation rate was 63% but 88% among patients with serum ferritin ≥1000 g/L. Of the 80chelated patients, 70% were chelated adequately mainly with deferasirox (26%) or deferasirox followingdeferoxamine (39%). Mortality was 70% among non-chelated, 40% among chelated, 32% among patientschelated ≥6 m, and 30% among patients chelated adequately; with a trend toward reduced cardiacmortality in chelated patients. Overall, median overall survival (OS) was 10.2 years for chelated and 3.1years for non-chelated patients (p < 0.001). For patients chelated ≥6 m or patients classified as adequatelychelated, median OS was 10.5 years. Mortality increased as a function of average monthly transfusionintensity (HR = 1.08, p = 0.04) but was lower in patients receiving adequate chelation or chelation ≥6 m(HR = 0.24, p < 0.001). Conclusion: Six or more months of adequate ICT is associated with markedly better overall survival. Thissuggests a possible survival benefit of ICT in transfusion-dependent patients with lower-risk MDS. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailQuelles dynamiques d'identification organisationnelle lors de processus de modernisation? Analyse d'une administration belge.
Rondeaux, Giseline ULg

in Revue Internationale des Sciences Administratives [= RISA] (2014), 80(mars), 110-130

In the course of reform, organizational identity emerges as a prominent issue. While the process of modernizing the administration sets out to redefine this identity, how is this experienced by its ... [more ▼]

In the course of reform, organizational identity emerges as a prominent issue. While the process of modernizing the administration sets out to redefine this identity, how is this experienced by its members? What are the identity dynamics at work in terms of their perception of changes in their environment? By analysing the Copernic reform in Belgium, we inductively developed a typology of identity rationales and profiles (Rondeaux, 2006, 2007, 2008, 2010). On this basis, we conducted a questionnaire survey in a regional administration engaged in reform. Our analysis highlights the coexistence of different identity rationales and diverse perceptions of the environment, which are congruent or dissonant with them. The results underline the importance of the environment and of its perception in organizational identification processes and confirms the hypothesis of identity hybridization, providing also an empirical basis for the integrative approach of Ravasi and Schultz (2006). [less ▲]

Detailed reference viewed: 111 (31 ULg)
Full Text
Peer Reviewed
See detailOutcomes of adults with active or progressive hematological malignancies at time of allogeneic stem cell transplantation : a survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Chevallier, P.; Labopin, M.; Milpied, N. et al

in Bone Marrow Transplantation (2014), 49

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective ... [more ▼]

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective study aimed to analyze the outcome of adult patients who received allo-SCT in a chemo-refractory/relapsed status. The series included 840 patients with active or progressive disease at the time of transplant. Median age was 50 years. With a median follow-up of 40 months, 3-year OS, disease-free survival (DFS), and non-relapse mortality rates were 29±2, 23±2, and 30±2%, respectively. At the last follow-up, 252 patients (30%) were still alive (of whom 201 were in CR (24%). In a Cox multivariate analysis, the use of a reduced-intensity conditioning (RIC) before allo-SCT and use of an HLA-identical sibling donor remained independently associated with a better OS (hazard ratio (HR)¼0.82; 95% confidence interval (CI), 0.69–0.98, P¼0.03; and HR¼0.79; 95% CI, 0.66–0.93, P¼0.006, respectively). Also, a diagnosis of myelodysplastic syndrome/myeloproliferative disorder, Hodgkin lymphoma and non-Hodgkin lymphoma compared with acute leukemia had a favorable impact on OS (HR¼0.55; 95% CI, 0.45–0.68, Po0.0001; HR¼0.49; 95% CI, 0.31–0.75, P¼0.001; and HR¼0.47; 95% CI, 0.35–0.63, Po0.0001, respectively). In conclusion, this study suggests that allo-SCT may be of benefit in some subgroups of patients with active or progressive hematological malignancies at the time of allo-SCT. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailÉtat des lieux des flux céréaliers en Wallonie selon différentes filières d’utilisation
Delcour, Alice ULg; Van Stappen, Florence; Gheysens, Stéphanie et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 181-192

Survey on cereal resources in Wallonia according to their different uses. Survey on cereal resources in Wallonia according to their different uses. More than 60% of the arable cropped area in Wallonia is ... [more ▼]

Survey on cereal resources in Wallonia according to their different uses. Survey on cereal resources in Wallonia according to their different uses. More than 60% of the arable cropped area in Wallonia is dedicated to cereals. Cereal chains were initially aimed at ensuring food security but are now progressively oriented towards new non-food uses. Walloon cereal chains are now having to face up to new global challenges: to ensure the competitiveness and sustainability of vegetal and animal chains, to match society's expectations and to meet the biomass needs for energy uses and bio-based products. Within this framework, this research aims to evaluate the environmental and socio-economic sustainability of future scenarios of current and potential food and non-food uses for Walloon cereals. This paper, the first in a series of two, presents the current picture of Walloon cereal crops and their uses. Various steps are analyzed: production, collection, wholesale and processing. Four main uses characterize cereal processing: the so-called "4Fs", representing Food (human food uses), Feed (animal feed uses), Fuel (energy uses) and Fiber (material uses). Data collected from stakeholders in the Walloon cereal chain enabled us to assess cereal flows for the "4Fs", drawing a qualitative and a quantitative picture of Walloon cereal resources including the key elements of the cereal chains. This approach serves as a basis for a prospective exercise, described in a companion paper, which develops potential uses for Walloon cereal resources at the 2030 horizon. [less ▲]

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailRC31, a strong and healthy Research Committee
Martiniello, Marco ULg

in RC-31 Newsletter: ISA International Sociological Association/Research Commitee on Sociology of Migration (2014), (Spring),

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detaildeltaPlotR: An R package for differential item functioning analysis with Angoff's Delta Plot
Magis, David ULg; Facon, Bruno

in Journal of Statistical Software (2014), 59(1), 1-19

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by ... [more ▼]

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by proposing an optimal threshold selection and by considering several item purification processes. Moreover, to support practical DIF analyses with the delta plot and these improvements, the R package deltaPlotR was also developed. The purpose of this paper is twofold: to outline the delta plot by describing the original method and its recent improvements in a user-oriented way, and to illustrate the structure and performances of the deltaPlotR package. A real data set about language skill assessment is being analyzed as an illustrative example. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailCurrent systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system
Ciais, P.; Dolman, A. J.; Bombelli, A. et al

in Biogeosciences (2014), 11(13), 3547--3602

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify ... [more ▼]

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires transformational advances from the existing sparse, exploratory framework towards a dense, robust, and sustained system in all components: anthropogenic emissions, the atmosphere, the ocean, and the terrestrial biosphere. The paper is addressed to scientists, policymakers, and funding agencies who need to have a global picture of the current state of the (diverse) carbon observations.We identify the current state of carbon observations, and the needs and notional requirements for a global integrated carbon observation system that can be built in the next decade. A key conclusion is the substantial expansion of the ground-based observation networks required to reach the high spatial resolution for CO2 and CH4 fluxes, and for carbon stocks for addressing policy-relevant objectives, and attributing flux changes to underlying processes in each region. In order to establish flux and stock diagnostics over areas such as the southern oceans, tropical forests, and the Arctic, in situ observations will have to be complemented with remote-sensing measurements. Remote sensing offers the advantage of dense spatial coverage and frequent revisit. A key challenge is to bring remote-sensing measurements to a level of long-term consistency and accuracy so that they can be efficiently combined in models to reduce uncertainties, in synergy with groundbased data. Bringing tight observational constraints on fossil fuel and land use change emissions will be the biggest challenge for deployment of a policy-relevant integrated carbon observation system. This will require in situ and remotely sensed data at much higher resolution and density than currently achieved for natural fluxes, although over a small land area (cities, industrial sites, power plants), as well as the inclusion of fossil fuel CO2 proxy measurements such as radiocarbon in CO2 and carbon-fuel combustion tracers. Additionally, a policy-relevant carbon monitoring system should also provide mechanisms for reconciling regional top-down (atmosphere-based) and bottom-up (surface-based) flux estimates across the range of spatial and temporal scales relevant to mitigation policies. In addition, uncertainties for each observation data-stream should be assessed. The success of the system will rely on long-term commitments to monitoring, on improved international collaboration to fill gaps in the current observations, on sustained efforts to improve access to the different data streams and make databases interoperable, and on the calibration of each component of the system to agreed-upon international scales. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailEpidemiology of Visceral Leishmaniasis in Algeria: An Update
Adel, A; Boughoufalah, A; Saegerman, Claude ULg et al

in PLoS ONE (2014), 9(6), 99207

Detailed reference viewed: 22 (11 ULg)
Full Text
Peer Reviewed
See detailErratum: Characterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogels (Microporous and Mesoporous Materials (2014) 184 (97-104))
Haghgoo, M.; Yousefi, A. A.; Zohouriaan Mehr, M. J. et al

in Microporous and Mesoporous Materials (2014), 195

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailStrategies for Using the Sheep Ovarian Cortex as a Model in Reproductive Medicine
Fransolet, Maïté ULg; Labied, Soraya ULg; Henry, Laurie ULg et al

in PLoS ONE (2014), 9(3), 91073

Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity ... [more ▼]

Objective: To evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity on the experimental results. Design: Histological study. Setting: Academic research center. Animals: Five- to nine-month-old ewes. Interventions: Freshly sampled whole sheep ovaries were collected and prepared for histological analysis. Main Outcome Measure(s): The follicular densities and distributions were determined for hematoxylin and eosin sections. A mathematical model was derived based on the follicle counts and Monte-Carlo simulations. Results: Heterogeneous distributions and densities of primordial follicles were identified 1) for distinct areas of the same ovarian cortex, 2) between the ovaries of the same animal and 3) across different ewes. A mathematical model based on the analysis of 37,153 primordial follicles from 8 different ovaries facilitated the estimation of the number of cortical biopsies and sections that had to be analyzed to overcome such heterogeneity. Conclusion: The influence of physiological follicular heterogeneity on experimental and clinical results can be overcome when a definite number of cortical pieces and sections are taken into consideration. [less ▲]

Detailed reference viewed: 11 (5 ULg)
Full Text
Peer Reviewed
See detailHeroin-assisted Tx superior to methadone for heroin addiction
Ansseau, Marc ULg

in Medscape medical news (2014)

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailExternal constraints on optical control strategies in molecular orientation and photofragmentation: role of zero-area fields
Sugny, Dominique; Vranckx, Stéphane; Ndong, Mamadou et al

in Journal of Modern Optics (2014), 61

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailSix leviers pour améliorer l'apprentissage des étudiants du supérieur
Poumay, Marianne ULg

in Revue Internationale de Pédagogie de l'Enseignement Supérieur (2014), 30(1),

Sur base de rapports rédigés par des centaines d’enseignants de l’ULg mais aussi sous l’influence de quelques auteurs en pédagogie universitaire, cet article présente six leviers de l’innovation ... [more ▼]

Sur base de rapports rédigés par des centaines d’enseignants de l’ULg mais aussi sous l’influence de quelques auteurs en pédagogie universitaire, cet article présente six leviers de l’innovation pédagogique dans le supérieur. Nous analysons ensuite une innovation – l’introduction de l’outil « GIC » dans un programme d’orthophonie de l’ULg – au regard de ces six leviers et mentionnons les régulations d’ordre pédagogique et d’ordre organisationnel envisagées pour l’année académique prochaine, de même que quelques pistes de recherche. Une conclusion rappelle le rôle de ces leviers, dont la prise en compte n’est pas une garantie de succès de l’innovation mais plutôt un moteur de changement au sein d’un cours ou d’un programme, gardant le cap sur l’apprentissage de l’étudiant. [less ▲]

Detailed reference viewed: 431 (37 ULg)
Full Text
Peer Reviewed
See detailRuptured subscapular artery aneurysm and subclavian artery occlusion in a patient with type 1 neurofibromatosis: a case report
MOREAU, Antoine; JOSKIN, Julien ULg; KREUTZ, Julie ULg et al

in Journal of Medical Case Reports (2014), 8

INTRODUCTION: Collateral muscular artery aneurysm is exceedingly rare. We report the first case of subscapular artery aneurysm in a patient with type 1 neurofibromatosis and ipsilateral chronic subclavian ... [more ▼]

INTRODUCTION: Collateral muscular artery aneurysm is exceedingly rare. We report the first case of subscapular artery aneurysm in a patient with type 1 neurofibromatosis and ipsilateral chronic subclavian artery occlusion. CASE PRESENTATION: A 74-year-old Caucasian woman with a medical history of type 1 neurofibromatosis, presented a sudden left pectoral mass, later diagnosed as a ruptured aneurysm of the left subscapular artery. It was caused by a chronic occlusion of the left subclavian artery, diagnosed on angiographies prior to embolization. CONCLUSIONS: Collateral artery aneurysm in the event of a mainstream muscular artery chronic occlusion may occur in type 1 neurofibromatosis. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
See detailVie et intériorité dans La Vie d'Adèle - le parti pris de l'extériorité
Hagelstein, Maud ULg; Janvier, Antoine ULg

in Cahiers du GRM (2014), 5

(Introduction) Mais pourquoi « la vie » d’Adèle ? À l’évidence, Kechiche ne nous en montre qu’une période limitée. Pourquoi alors La Vie d’Adèle, et pas : L’adolescence d’Adèle, La passion d’Adèle, Adèle ... [more ▼]

(Introduction) Mais pourquoi « la vie » d’Adèle ? À l’évidence, Kechiche ne nous en montre qu’une période limitée. Pourquoi alors La Vie d’Adèle, et pas : L’adolescence d’Adèle, La passion d’Adèle, Adèle et Emma, ou Les amours d’Adèle ? Le spectateur est prévenu depuis longtemps, on le lui a assez dit : le film met en scène l’histoire d’une adolescente qui cherche sa vérité intime. Et quoi de plus intime qu’une passion amoureuse ? Kechiche ne manque pas d’exposer au regards les séquences les plus privées d’une telle passion, dans de longues scènes qui ont tant fait parler d’elles. Le cadre interprétatif est là, tout prêt : Adèle éprouve les aléas de la recherche incertaine de soi ; elle fait l’épreuve de ce rite initiatique des sociétés modernes qui est en même temps le moment privilégié d’expérimentation et de construction du sujet. La Vie d’Adèle, Bildungsroman d’une jeune lilloise du 21ème siècle testant différentes configurations amoureuses avant d’approcher la vérité de son désir : d’abord un garçon, puis une copine de lycée, puis Emma, puis d’autres aventures, et pour finir, peut-être, un jeune homme. Sauf que cette « formation » ne débouche sur aucune forme subjective achevée. Adèle se cherche-t-elle vraiment ? Et surtout : est-ce là le sujet réel du film (au double sens du terme : aussi bien le thème choisi par le cinéaste que la subjectivité autour de laquelle tourne La Vie d’Adèle) ? [less ▲]

Detailed reference viewed: 19 (3 ULg)