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See detailThe European Commission’s geo-blocking proposals and the future of EU e-commerce regulation
Van Cleynenbreugel, Pieter ULg

in Masaryk University Journal of Law and Technology (2017), 11(1), 39-62

As part of its Digital Single Market strategy, the European Commission envisages to take action aimed at eradicating the practice of blocking one’s website to persons established or residing in a ... [more ▼]

As part of its Digital Single Market strategy, the European Commission envisages to take action aimed at eradicating the practice of blocking one’s website to persons established or residing in a particular EU Member State. To that extent, a 2015 pro-posal for a regulation on the portability of online streaming services and a 2016 pro-posal for a regulation on geo-blocking outside the audio-visual context have been presented, the scope of which will be analysed in this paper. Although the proposed Regulations would tackle topical problems in EU e commerce and thus offer a necessary step forward in enhancing cross-border trade in the European Union, their envisaged regulatory approach raises important con-cerns from enforcement and rules’ circumvention points of view. Taking stock of those two concerns, the paper will reflect upon ways to mitigate their detrimental effects. Arguing that the geo-blocking proposals already contain the basic tools for such mitigation, the paper advocates the adoption of a more stream-lined EU competition law and e-commerce regulation enforcement strategy, comple-mented by a “technologically more pro-active” EU law interpretation stance to e-commerce at the EU level. [less ▲]

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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailEcho-Doppler estimation of left ventricular filling pressure: results of the multicentre EACVI Euro-Filling study
Lancellotti, Patrizio ULg; Galderisi, M; Edvardsen, T et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims: The present Euro-Filling report aimed at comparing the diagnostic accuracy of the 2009 and 2016 echocardiographic grading algorithms for predicting invasively measured left ventricular filling ... [more ▼]

Aims: The present Euro-Filling report aimed at comparing the diagnostic accuracy of the 2009 and 2016 echocardiographic grading algorithms for predicting invasively measured left ventricular filling pressure (LVFP). Method and results: A total of 159 patients who underwent simultaneous evaluation of echo estimates of LVFP and invasive measurements of LV end-diastolic pressure (LVEDP) were enrolled at nine EACVI centres. Thirty-nine (25%) patients had a reduced LV ejection fraction (<50%), 77 (64%) were in NYHA ≥ II, and 85 (53%) had coronary artery disease. Sixty-four (40%) patients had elevated LVEDP (≥15 mmHg). Taken individually, all echocardiographic Doppler estimates of LVFP (E/A, E/e', left atrial volume, tricuspid regurgitation jet velocity) were marginally correlated with LVEDP. By using the 2016 recommendations, 65% of patients with normal non-invasive estimate of LVFP had normal LVEDP, while 79% of those with elevated non-invasive LVFP had elevated invasive LVEDP. By using 2009 recommendations, 68% of the patients with normal non-invasive LVFP had normal LVEDP, while 55% of those with elevated non-invasive LVFP had elevated LVEDP. The 2016 recommendations (sensitivity 75%, specificity 74%, positive predictive value 39%, negative predictive value 93%, AUC 0.78) identified slightly better patients with elevated invasive LVEDP (≥ 15 mmHg) as compared with the 2009 recommendations (sensitivity 43%, specificity 75%, positive predictive value 49%, negative predictive value 71%, AUC 0.68). Conclusion: The present Euro-Filling study demonstrates that the new 2016 recommendations for assessing LVFP non-invasively are fairly reliable and clinically useful, as well as superior to the 2009 recommendations in estimating invasive LVEDP. [less ▲]

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See detailEffects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study
Gaul, Charly; MAGIS, Delphine ULg; Liebler, Eric et al

in Journal of Headache and Pain (2017), 18

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve ... [more ▼]

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study. Findings: After a 2-week baseline phase, 97 patients with chronic cluster headache entered a 4-week randomised phase to receive nVNS + SoC (n = 48) or SoC alone (n = 49). All 92 patients who continued into a 4-week extension phase received nVNS + SoC. Compared with SoC alone, nVNS + SoC led to a significantly lower mean weekly attack frequency by week 2 of the randomised phase; the attack frequency remained significantly lower in the nVNS + SoC group through week 3 of the extension phase (P < 0.02). Attack frequencies in the nVNS + SoC group were significantly lower at all study time points than they were at baseline (P < 0.05). Response rates were significantly greater with nVNS + SoC than with SoC alone when response was defined as attack frequency reductions of ≥25%, ≥50%, and ≥75% from baseline (≥25% and ≥50%, P < 0.001; ≥75%, P = 0.009). The 100% response rate was 8% with nVNS + SoC and 0% with SoC alone. Conclusions: Prophylactic nVNS led to rapid, significant, and sustained reductions in chronic cluster headache attack frequency within 2 weeks after its addition to SoC and was associated with significantly higher ≥25%, ≥50%, and ≥75% response rates than SoC alone. The rapid decrease in weekly attack frequency justifies a 4-week trial period to identify responders to nVNS, with a high degree of confidence, among patients with chronic cluster headache. [less ▲]

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See detailOn the role of secondary pions in spallation targets
Cugnon, Joseph ULg; Mancusi, Davide; Lo Meo, Sergio et al

in European Physics Journal A (2017), 53

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See detailPsychopathologie phénoménologique : Apports contemporains et défis futurs
Englebert, Jérôme ULg

in Neurone (2017), 22(7),

Cet article retrace l’historique de la psychopathologie phénoménologique, née il y a 100 ans, et fait la synthèse des apports de la phénoménologie à la psychopathologie. Il a pour objectif, d’une part, de ... [more ▼]

Cet article retrace l’historique de la psychopathologie phénoménologique, née il y a 100 ans, et fait la synthèse des apports de la phénoménologie à la psychopathologie. Il a pour objectif, d’une part, de présenter l’un des apports récents de la psychopathologie phénoménologique à la connaissance d’une maladie mentale incontournable, à savoir la schizophrénie et, d’autre part, de souligner les défis et d’esquisser les perspectives et projets que cette discipline renaissante semble susciter. [less ▲]

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See detailCardiopulmonary exercise testing is a better outcome predictor than exercise echocardiography in asymptomatic aortic stenosis.
Domanski, Olivia; Richardson, Marjorie; Coisne, Augustin et al

in International Journal of Cardiology (2017), 227

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship ... [more ▼]

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship between peak VO2 and AS severity criteria derived from rest and supine exercise echocardiography (SEE) has never been explored. OBJECTIVES: We aimed to determine whether low peak VO2 (<85% of predicted value) is associated with severity parameters in SEE, and poor clinical outcome. METHODS: Fifty one asymptomatic patients (mean age of 54+/-21years) with moderate to severe aortic stenosis (Vmax>3m/s) and left ventricle ejection fraction>50% prospectively underwent resting and SEE and cardiopulmonary exercise testing (CPX). RESULTS: Peak VO2 was lower than expected (21.9+/-7.4mL/kg/min), i.e. <85% of predicted value in 57% patients, secondary to cardiac limitation in most of them (69%). In multiple regression analysis, age, BMI and female gender were the only independent determinants of peak VO2. Interestingly no parameter derived from SEE was associated with peak VO2. After 21+/-7month follow-up, no patient died, 20 underwent cardiac surgery. Peak VO2<85% of predicted value was associated with lower event free survival compared to normal peak VO2 (57%+/-11% vs 93+/-6%, p=0.036) whereas no exercise echocardiographic parameter could predict such events. Peak VO2>/=85% had a negative predictive value of 97%. CONCLUSION: CPX detects a high proportion of false asymptomatic AS patients with poorer outcome that cannot be predicted by SEE markers of AS severity. Assessment of aerobic capacity should be part of current approach within a "watchful waiting" strategy. [less ▲]

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See detailImplications of the calcium-sensing receptor in ischemia/reperfusion.
Paquot, Francois ULg; Huart, Justine; Defraigne, Jean-Olivier ULg et al

in Acta Cardiologica (2017), 72(2), 125-131

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) which was first isolated from bovine parathyroid glands. Its complex structure has been well characterized, which helped to ... [more ▼]

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) which was first isolated from bovine parathyroid glands. Its complex structure has been well characterized, which helped to better understand its function. The CaSR activity can be modulated by various ligands, either activators (also called "calcimimetics") or inhibitors (or "calcilytics"). The main role of the CaSR concerns Ca2+ homeostasis. In bone, intestine and kidney, the CaSR acts as a sensor for extracellular ionized Ca2+ concentration ([Ca2+]e) to keep it stable. Such a homeostatic function is well illustrated by human inherited diseases caused by mutations in CASR gene, characterized by Ca2+ balance disturbances. Interestingly, the CaSR is also expressed in numerous tissues which are not directly involved in Ca2+ regulation. There, the CaSR has been implicated in regulatory pathways, including cell proliferation, differentiation and apoptosis. Moreover, recent observations suggest that the CaSR may be involved in ischaemia/reperfusion (I/R) cascades. In cardiomyocytes, the expression and activation of the CaSR are significantly induced at the time of I/R, which induces apoptotic pathways. Likewise, the activation of the CaSR in I/R in brain, liver and kidney has been associated with increased cell death and aggravated structural and functional damage. The present review summarizes these observations and hypothesizes a novel therapeutic option targeting the CaSR in I/R. [less ▲]

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See detailInterpreting ‘grief’ in Senegal: language, emotions and cross-cultural translation in a francophone African context
Ruth, Evans; Jane; Fatou, Kebe et al

in Mortality (2017)

This article reflects on the profound complexities of translating and interpreting ‘grief’, and emotions and responses to death more broadly, in multilingual, cross-cultural contexts. Drawing on ... [more ▼]

This article reflects on the profound complexities of translating and interpreting ‘grief’, and emotions and responses to death more broadly, in multilingual, cross-cultural contexts. Drawing on qualitative research conducted in urban Senegal, West Africa, we discuss the exchange of meanings surrounding grief and death through language, including the process of translation, in its broadest sense, between multiple languages (Wolof, French, English). Our experiences demonstrate the crucial importance of involving interpreters and field researchers throughout the research process, to gain fundamental insight into the cultural nuances of indigenous languages and how these are translated and potentially re-framed in the process. We reflect on our iterative process of discussing emerging interpretations with participants in follow-up workshops and with our interpreter. This approach helped shed light on language use surrounding ‘grief’ and how this is bound up with wider socio-cultural norms which make particular emotions surrounding death and experiences/meanings of death and bereavement possible and ‘speak-able’. Our research calls for greater recognition in death and bereavement studies of the cultural specificity of conceptual frameworks developed in minority European socio-linguistic contexts and demonstrates the need for greater engagement with theoretical, empirical and methodological insights gained in diverse cultural contexts in the Majority world. [less ▲]

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See detailPharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the Chondroitin versus Celecoxib versus placebo trial (CONCEPT)
Reginster, Jean-Yves ULg; Dudler, J; Blicharski, T et al

in Annals of the Rheumatic Diseases (2017), 0n line

Objectives : Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. Methods: A prospective ... [more ▼]

Objectives : Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. Methods: A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing changes in pain on a Visual Analogue Scale (VAS) and in the Lequesne Index (LI) as coprimary endpoints. Minimal-Clinically Important Improvement (MCII), Patient-Acceptable Symptoms State (PASS) were used as secondary endpoints. Results: 604 patients (knee osteoarthritis) diagnosed according to American College of Rheumalogy (ACR) criteria, recruited in five European countries and followed for 182 days. CS and celecoxib showed a greater significant reduction in pain and LI than placebo. In the intention-to-treat (ITT) population, pain reduction in VAS at day 182 in the CS group (−42.6 mm) and in celecoxib group (−39.5 mm) was significantly greater than the placebo group (−33.3 mm) (p=0.001 for CS and p=0.009 for celecoxib), while no difference observed between CS and celecoxib. Similar trend for the LI, as reduction in this metric in the CS group (−4.7) and celecoxib group (−4.6) was significantly greater than the placebo group (−3.7) (p=0.023 for CS and p=0.015 for celecoxib), no difference was observed between CS and celecoxib. Both secondary endpoints (MCII and PASS) at day 182 improved significantly in the CS and celecoxib groups. All treatments demonstrated excellent safety profiles. Conclusion: A 800 mg/day pharmaceutical-grade CS is superior to placebo and similar to celecoxib in reducing pain and improving function over 6 months in symptomatic knee osteoarthritis (OA) patients. This formulation of CS should be considered a first-line treatment in the medical management of knee OA. [less ▲]

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See detailContrasted terrace systems of the lower Moulouya river as indicator of crustal deformation in NE Morocco
Rixhon, Gilles; Bartz, Melanie; El Ouahabi, Meriam ULg et al

in Journal of African Earth Sciences (2017)

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See detail1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases
Sevaille, Laurent; Gavara, Laurent; Bebrone, Carine et al

in ChemMedChem (2017), 12

Metallo-β-lactamases (MBLs) cause resistance of Gram-negative bacteria to β-lactam antibiotics and are of serious concern, because they can inactivate the last-resort carbapenems and because MBL ... [more ▼]

Metallo-β-lactamases (MBLs) cause resistance of Gram-negative bacteria to β-lactam antibiotics and are of serious concern, because they can inactivate the last-resort carbapenems and because MBL inhibitors of clinical value are still lacking. We previously identified the original binding mode of 4-amino-2,4-dihydro-5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione (compound IIIA) within the dizinc active site of the L1 MBL. Herein we present the crystallographic structure of a complex of L1 with the corresponding non-amino compound IIIB (1,2-dihydro-5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione). Unexpectedly, the binding mode of IIIB was similar but reverse to that of IIIA. The 3 D structures suggested that the triazole-thione scaffold was suitable to bind to the catalytic site of dizinc metalloenzymes. On the basis of these results, we synthesized 54 analogues of IIIA or IIIB. Nineteen showed IC50 values in the micromolar range toward at least one of five representative MBLs (i.e., L1, VIM-4, VIM-2, NDM-1, and IMP-1). Five of these exhibited a significant inhibition of at least four enzymes, including NDM-1, VIM-2, and IMP-1. Active compounds mainly featured either halogen or bulky bicyclic aryl substituents. Finally, some compounds were also tested on several microbial dinuclear zinc-dependent hydrolases belonging to the MBL-fold superfamily (i.e., endonucleases and glyoxalase II) to explore their activity toward structurally similar but functionally distinct enzymes. Whereas the bacterial tRNases were not inhibited, the best IC50 values toward plasmodial glyoxalase II were in the 10 μm range. [less ▲]

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See detailComputational methods in manufacturing
Ponthot, Jean-Philippe ULg; Feulvarch, Eric; Drapier, Sylvain et al

in International Journal of Material Forming (2017), 10

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See detailRational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy
Donal, E; Delgado, V; Magne, J et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several ... [more ▼]

Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. METHODS: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging. [less ▲]

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See detailNanomedicine as a potent strategy in melanoma tumor microenvironment
Pautu, Vincent ULg; Leonetti, Daniela; Lepeltier, Elise et al

in Pharmacological Research (2017)

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See detailBetween Atlantic and Mediterranean: Changes in technology during the Late Glacial in Western Europe and the climate hypothesis
Naudinot, Nicolas; Tomasso, Antonin ULg; Messager, Erwann et al

in Quaternary International (2017), 52

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See detailBehavioral fever in ectothermic vertebrates.
Rakus, Krzysztof; Ronsmans, Maygane; Vanderplasschen, Alain ULg

in Developmental & Comparative Immunology (2017), 66

Fever is an evolutionary conserved defense mechanism which is present in both endothermic and ectothermic vertebrates. Ectotherms in response to infection can increase their body temperature by moving to ... [more ▼]

Fever is an evolutionary conserved defense mechanism which is present in both endothermic and ectothermic vertebrates. Ectotherms in response to infection can increase their body temperature by moving to warmer places. This process is known as behavioral fever. In this review, we summarize the current knowledge on the mechanisms of induction of fever in mammals. We further discuss the evolutionary conserved mechanisms existing between fever of mammals and behavioral fever of ectothermic vertebrates. Finally, the experimental evidences supporting an adaptive value of behavioral fever expressed by ectothermic vertebrates are summarized. [less ▲]

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See detailConstant 2-labellings and an application to (r,a,b)-covering codes
Vandomme, Elise ULg; Gravier, Sylvain

in Discussiones Mathematicae Graph Theory (2017), 37(4), 891-918

We introduce the concept of constant 2-labelling of a vertex-weighted graph and show how it can be used to obtain perfect weighted coverings. Roughly speaking, a constant 2-labelling of a vertex-weighted ... [more ▼]

We introduce the concept of constant 2-labelling of a vertex-weighted graph and show how it can be used to obtain perfect weighted coverings. Roughly speaking, a constant 2-labelling of a vertex-weighted graph is a black and white colouring of its vertex set which preserves the sum of the weights of black vertices under some automorphisms. We study constant 2-labellings on four types of vertex-weighted cycles. Our results on cycles allow us to determine (r, a, b)-codes in Z^2 whenever |a−b|>4, r>1 and we give the precise values of a and b. This is a refinement of Axenovich’s theorem proved in 2003. [less ▲]

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See detailPlasma effects on atomic data for the K-vacancy states of highly charged iron ions
Deprince, J.; Fritzsche, S.; Kallman, T.R. et al

in AIP Conference Proceedings (2017), 1811

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See detailImproved pressure contour analysis for estimating cardiac stroke volume using pulse wave velocity measurement.
Kamoi, Shun; Pretty, Christopher; Balmer, Joel et al

in BioMedical Engineering OnLine (2017), 16(1), 51

BACKGROUND: Pressure contour analysis is commonly used to estimate cardiac performance for patients suffering from cardiovascular dysfunction in the intensive care unit. However, the existing techniques ... [more ▼]

BACKGROUND: Pressure contour analysis is commonly used to estimate cardiac performance for patients suffering from cardiovascular dysfunction in the intensive care unit. However, the existing techniques for continuous estimation of stroke volume (SV) from pressure measurement can be unreliable during hemodynamic instability, which is inevitable for patients requiring significant treatment. For this reason, pressure contour methods must be improved to capture changes in vascular properties and thus provide accurate conversion from pressure to flow. METHODS: This paper presents a novel pressure contour method utilizing pulse wave velocity (PWV) measurement to capture vascular properties. A three-element Windkessel model combined with the reservoir-wave concept are used to decompose the pressure contour into components related to storage and flow. The model parameters are identified beat-to-beat from the water-hammer equation using measured PWV, wave component of the pressure, and an estimate of subject-specific aortic dimension. SV is then calculated by converting pressure to flow using identified model parameters. The accuracy of this novel method is investigated using data from porcine experiments (N = 4 Pietrain pigs, 20-24.5 kg), where hemodynamic properties were significantly altered using dobutamine, fluid administration, and mechanical ventilation. In the experiment, left ventricular volume was measured using admittance catheter, and aortic pressure waveforms were measured at two locations, the aortic arch and abdominal aorta. RESULTS: Bland-Altman analysis comparing gold-standard SV measured by the admittance catheter and estimated SV from the novel method showed average limits of agreement of +/-26% across significant hemodynamic alterations. This result shows the method is capable of estimating clinically acceptable absolute SV values according to Critchely and Critchely. CONCLUSION: The novel pressure contour method presented can accurately estimate and track SV even when hemodynamic properties are significantly altered. Integrating PWV measurements into pressure contour analysis improves identification of beat-to-beat changes in Windkessel model parameters, and thus, provides accurate estimate of blood flow from measured pressure contour. The method has great potential for overcoming weaknesses associated with current pressure contour methods for estimating SV. [less ▲]

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See detailOn the numerical simulation of sheet metal blanking process
Canales Cardenas, Cristian ULg; Bussetta, Philippe; Ponthot, Jean-Philippe ULg

in International Journal of Material Forming (2017), 10

The use of the blanking process has been widely spread in mass production industries. In this technique, the quality of the final product is directly related to the setting parameters of the process and ... [more ▼]

The use of the blanking process has been widely spread in mass production industries. In this technique, the quality of the final product is directly related to the setting parameters of the process and the material response of the sheet. In the present work, a general framework based on the finite element method for the simulation of the sheet metal blanking process is presented. The proposed approach properly addresses all the numerical challenges related to blanking. First, an extension of elasto-viscoplastic constitutive equations for the large strain regime is used to take into account the material strain-rate sensitivity. Then, the inertial effects coming from high velocity operations are considered by means of an implicit time integration scheme. Moreover, the frictional contact interactions are simulated with the classical Coulomb law and an energetically consistent formulation of area regularization. Finally, ductile fracture is modeled thanks to the element deletion method coupled with a fracture criterion. The blanking process is then simulated for different setting parameters. The accuracy of this approach is evaluated by comparing the numerical predictions to experimental results for both quasi-static and dynamic conditions. Good agreement is found between experimental and numerical results for all cases. [less ▲]

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See detailQuadratic reformulations of nonlinear binary optimization problems
Anthony, Martin; Boros, Endre; Crama, Yves ULg et al

in Mathematical Programming (2017), 162

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these ... [more ▼]

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these problems when the objective function is a quadratic polynomial. However, no similarly efficient methods are available for the higher degree case. Since high degree objectives are becoming increasingly important in certain application areas, such as computer vision, various techniques have been recently developed to reduce the general case to the quadratic one, at the cost of increasing the number of variables. In this paper we initiate a systematic study of these quadratization approaches. We provide tight lower and upper bounds on the number of auxiliary variables needed in the worst-case for general objective functions, for bounded-degree functions, and for a restricted class of quadratizations. Our upper bounds are constructive, thus yielding new quadratization procedures. Finally, we completely characterize all ``minimal'' quadratizations of negative monomials. [less ▲]

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See detailOsteoporosis in Frail Patients: A Consensus Paper of the Belgian Bone Club.
Gielen, E.; Bergmann, P.; Bruyère, Olivier ULg et al

in Calcified Tissue International (2017), 101(2), 111-31

In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia ... [more ▼]

In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia nervosa, patients on dialysis, cancer patients, persons with sarcopenia, and the oldest old. All these conditions may indeed induce bone loss that is superimposed on physiological bone loss and often remains under-recognized and under-treated. This is of particular concern because of the major burden of osteoporotic fractures in terms of morbidity, mortality, and economic cost. Therefore, there is an urgent need to appreciate bone loss associated with these conditions, as this may improve diagnosis and management of bone loss and fracture risk in clinical practice. [less ▲]

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See detailAlpha-lipoic acid impairs body weight gain of young broiler chicks via modulating peripheral AMPK.
Wang, Yufeng; Everaert, Nadia ULg; Song, Zhigang et al

in Comparative Biochemistry and Physiology Part A : Molecular & Integrative Physiology (2017), 211

In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was ... [more ▼]

In mammals, the AMP-activated protein kinase (AMPK) pathways in the central and peripheral tissues coordinately integrate inputs from multiple sources to regulate energy balance. The present study was aimed to explore the potential role of hepatic AMPK in the energy homeostasis of broiler chickens. Diets with 0, 0.05% or 0.1% alpha-lipoic acid (alpha-LA), a known AMPK inhibitor were provided to broiler chicks for 7days. As a result, alpha-LA supplementation decreased the relative growth rate of broiler chicks. Hepatic AMPKalpha2 mRNA levels were significantly upregulated by dietary alpha-LA, in concert with the increased phosphorylated AMPKalpha protein levels. In addition, hepatic FAS mRNA levels together with the malonyl-CoA to total CoA ester ratio were reduced by alpha-LA supplementation. Moreover, the hepatic phosphorylated glycogen synthase levels were increased resulting in a markedly decreased hepatic glycogen content. In conclusion, dietary alpha-LA supplementation decreased the in vivo hepatic glycogenesis and lipogenesis via stimulating hepatic AMPKalpha mRNA levels and the phosphorylated gene product. The stimulatory effect of alpha-LA on hepatic AMPK mRNA and pAMPKalpha protein levels together with our previous observations regarding its inhibitory effect on hypothalamic AMPK may have altered the energy balance and hence impaired body weight gain of broiler chicks. [less ▲]

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See detailDistinction between urine crystals by automated urine analyzer SediMAX conTRUST is specific but lacks of sensitivity.
Castiglione, Vincent ULg; CAVALIER, Etienne ULg; Diop, Coumba Souley ULg et al

in Clinical Chemistry & Laboratory Medicine (2017)

Urine crystals are commonly encountered but few papers have been published about it while it is useful for patient’s follow-up, particularly the stone-formers. For the first time to our knowledge, we have ... [more ▼]

Urine crystals are commonly encountered but few papers have been published about it while it is useful for patient’s follow-up, particularly the stone-formers. For the first time to our knowledge, we have assessed the performance of an automated urine analyzer to identify and distinguish several types of crystals in a very large cohort of samples. We share in this report the results of method comparison of the SediMAX conTRUST with the polarized light microscopy which is the gold standard. We showed that the distinction between crystals and other urine elements was accurate. Negative predictive value was very good, but the positive predictive value was poor for most of crystals. The discrimination of different types of crystals between them by the automated urine analyzer still requires improvement to decrease reviewing rate and help clinician. [less ▲]

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See detailMolecular mechanisms, current management and next generation therapy in myeloma bone disease.
Heusschen, Roy ULg; Muller, Joséphine ULg; Duray, Elodie ULg et al

in Leukemia & Lymphoma (2017)

Multiple myeloma (MM) bone disease is a major cause of morbidity and mortality in MM patients and persists even in patients in remission. This bone disease is caused by an uncoupling of bone remodeling ... [more ▼]

Multiple myeloma (MM) bone disease is a major cause of morbidity and mortality in MM patients and persists even in patients in remission. This bone disease is caused by an uncoupling of bone remodeling, with increased osteoclast and decreased osteoblast activity and formation, culminating in lytic bone destruction. Bisphosphonates are the current standard of care but new therapies are needed. As the molecular mechanisms controlling MM bone disease are increasingly well understood, new therapeutic targets are extensively explored in the preclinical setting and initial clinical trials with novel compounds now show promising results. In this review, we will provide a comprehensive overview of the biology of MM bone disease, summarize its current clinical management and discuss preclinical and clinical data on next generation therapies. [less ▲]

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See detailLes intercommunales et les impôts sur les revenus : une valse fiscale à deux temps
Garroy, Sabine ULg

in ASBL Actualités (2017)

En 2014 et 2015, le régime fiscal des intercommunales a été revu de manière substantielle. Nous nous proposons, après une première section consacrée au cadre légal dans lequel cette réforme s’inscrit (I ... [more ▼]

En 2014 et 2015, le régime fiscal des intercommunales a été revu de manière substantielle. Nous nous proposons, après une première section consacrée au cadre légal dans lequel cette réforme s’inscrit (I), de décrire les grandes lignes de cette réforme suivant le rythme d’une valse à deux temps (II) ainsi que de livrer un bref commentaire de la circulaire administrative 10/2016 à l’occasion duquel nous nous interrogerons sur les éventuelles implications de cette réforme sur des personnes morales relevant du droit privé, les associations sans but lucratif (ci-après : ASBL) notamment (III). [less ▲]

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See detailThe use of oxytocin to improve feeding and social skills in infants with Prader-Willi syndrome
Tauber, Maïthé; Boulanouar, Kader; Gwenaelle, Diene et al

in Pediatrics (2017), 139(2),

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults ... [more ▼]

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults. Animal data demonstrated that early treatment with OXT restores sucking after birth. Our aim is to reproduce these data in infants with PWS. METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 infants in each step) who received 4 IU of OXT either every other day, daily, or twice daily. We investigated the tolerance and the effects on feeding and social skills and changes in circulating ghrelin and brain connectivity by functional MRI. RESULTS: No adverse events were reported. No dose effect was observed. Sucking assessed by the Neonatal Oral-Motor Scale was abnormal in all infants at baseline and normalized in 88% after treatment. The scores of Neonatal Oral-Motor Scale and videofluoroscopy of swallowing significantly decreased from 16 to 9 (P < .001) and from 18 to 12.5 (P < .001), respectively. Significant improvements in Clinical Global Impression scale scores, social withdrawal behavior, and mother–infant interactions were observed. We documented a significant increase in acylated ghrelin and connectivity of the right superior orbitofrontal network that correlated with changes in sucking and behavior. CONCLUSIONS: OXT is well tolerated in infants with PWS and improves feeding and social skills. These results open perspectives for early treatment in neurodevelopment diseases with feeding problems. [less ▲]

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See detailDevelopment and validation of a fast SFC method for the analysis of flavonoids in plant extracts.
Huang, Yang; Feng, Ying; Tang, Guangyun et al

in Journal of Pharmaceutical & Biomedical Analysis (2017), 140

Flavonoids from plants always show a wide range of biological activities. In the present study, a rapid and highly efficient supercritical fluid chromatography (SFC) method was developed for the ... [more ▼]

Flavonoids from plants always show a wide range of biological activities. In the present study, a rapid and highly efficient supercritical fluid chromatography (SFC) method was developed for the separation of 12 flavonoids. After careful optimization, the 12 flavonoids were baseline separated on a ZORBAX RX-SIL column using gradient elution. A 0.1% phosphoric acid solution in methanol was found to be the most suitable polar mobile phase component for the separation of flavonoids. From the viewpoint of retention and resolution, a backpressure of 200bar and a temperature of 40 degrees C were shown to give the best results. Compared with a previously developed reverse phase liquid chromatography method, the SFC method could provide flavonoid separations that were about three times faster, while maintaining good peak shape and comparable peak efficiency. This SFC method was validated and applied to the analysis of five flavonoids (kaempferol, luteolin, quercetin, luteoloside, buddleoside) present in Chrysanthemum morifolium Ramat. from different cultivars (Chuju, Gongju, Hangju, Boju). The results indicated a good repeatability and sensitivity for the quantification of the five analytes with RSDs for overall precision lower than 3%. The limits of detection ranged from 0.73 to 2.34mug/mL, while the limits of quantification were between 2.19 and 5.86mug/mL. The method showed that SFC could be employed as a useful tool for the quality assessment of Traditional Chinese medicines (TCMs) containing flavonoids as active components. [less ▲]

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See detailContribution of past and future self-defining event networks to personal identity
Demblon, Julie; D'Argembeau, Arnaud ULg

in Memory (2017), 25

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See detailFifth European Dirofilaria and Angiostrongylus Days (FiEDAD) 2016
Simón, F.; Kartashev, V.; González-Miguel, J. et al

in Parasites & Vectors (2017), 10(1), 5

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See detailIntroduction de la section "Récits de pratique"
Simons, Germain ULg; Beckers, Jacqueline ULg; De Croix, Séverine et al

in Didactiques en Pratique (2017), 3

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See detailThe three-dimensional rectangular Multiple Bin Size Bin Packing Problem with transportation constraints: A case study in the field of air transportation
Paquay, Célia ULg

in 4OR : Quarterly Journal of the Belgian, French and Italian Operations Research Societies (2017)

Ph. D Thesis summary see other reference on ORBI

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See detailNew crystallographic data and formula revision of phuralumite, Al2[(UO2)3(PO4)2O(OH)](OH)3(H2O)9
Dal Bo, Fabrice ULg; Hatert, Frédéric ULg; Philippo, S

in Journal of Geosciences (2017), 62

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See detailEditorial
Simons, Germain ULg; Beckers, Jacqueline ULg; De Croix, Séverine et al

in Didactiques en Pratique (2017), 3

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See detailCrossing the dividing surface of transition state theory. IV. Dynamical regularity and dimensionality reduction as as key features of reactive trajectories
Lorquet, Jean-Claude ULg

in The Journal of Chemical Physics (2017), 146

The atom-diatom interaction is studied by classical mechanics using Jacobi coordinates (R, r, θ). Reactivity criteria that go beyond the simple requirement of transition state theory (i.e., PR* > 0) are ... [more ▼]

The atom-diatom interaction is studied by classical mechanics using Jacobi coordinates (R, r, θ). Reactivity criteria that go beyond the simple requirement of transition state theory (i.e., PR* > 0) are derived in terms of specific initial conditions. Trajectories that exactly fulfill these conditions cross the conventional dividing surface used in transition state theory (i.e., the plane in configuration space passing through a saddle point of the potential energy surface and perpendicular to the reaction coordinate) only once. Furthermore, they are observed to be strikingly similar and to form a tightly-packed bundle of perfectly collimated trajectories in the two-dimensional (R, r) configuration space, although their angular motion is highly specific for each one. Particular attention is paid to symmetrical transition states (i.e., either collinear or T-shaped with C2v symmetry) for which decoupling between angular and radial coordinates is observed, as a result of selection rules that reduce to zero Coriolis couplings between modes that belong to different irreducible representations. Liapunov exponents are equal to zero and Hamilton's characteristic function is planar in that part of configuration space that is visited by reactive trajectories. Detailed consideration is given to the concept of average reactive trajectory, which starts right from the saddle point and which is shown to be free of curvature-induced Coriolis coupling. The reaction path Hamiltonian model, together with a symmetry-based separation of the angular degree of freedom, provide an appropriate framework that leads to the formulation of an effective two-dimensional Hamiltonian. The success of the adiabatic approximation in this model is due to the symmetry of the transition state, not to a separation of time scales. Adjacent trajectories, i.e., those that do not exactly fulfill the reactivity conditions have similar characteristics, but the quality of the approximation is lower. At higher energies, these characteristics persist, but to a lesser degree. Recrossings of the dividing surface then become much more frequent and the phase space volume of initial conditions that generate recrossing-free trajectories decreases. Altogether, one ends up with an additional illustration of the concept of reactive cylinder (or conduit) in phase space that reactive trajectories must follow. Reactivity is associated with dynamical regularity and dimensionality reduction, whatever the shape of the potential energy surface, no matter how strong its anharmonicity, and whatever the curvature of its reaction path. Both simplifying features persist during the entire reactive process, up to complete separation of fragments. The ergodicity assumption commonly assumed in statistical theories is inappropriate for reactive trajectories. [less ▲]

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See detailGlobal longitudinal strain predicts outcome after MitraClip implantation for secondary mitral regurgitation
Citro, R; Baldi, C; Lancellotti, Patrizio ULg et al

in Journal of Cardiovascular Medicine (Hagerstown, Md.) (2017)

AIM: The aim of this study was to assess preoperative determinants, prevalence, and prognostic impact of left ventricular (LV) reverse remodeling (LVRR) in patients with secondary mitral regurgitation ... [more ▼]

AIM: The aim of this study was to assess preoperative determinants, prevalence, and prognostic impact of left ventricular (LV) reverse remodeling (LVRR) in patients with secondary mitral regurgitation (SMR), undergoing MitraClip implantation (MCi). METHODS: From March 2012 to January 2015, a total of 41 consecutive patients with moderate-to-severe SMR treated successfully with MCi were enrolled. All patients underwent clinical and echocardiographic follow-up after MCi. Global longitudinal strain (GLS) was obtained using two dimensional speckle tracking analysis. A reduction in LV end-systolic volume more than 10% compared with baseline was considered as a marker of LVRR. Patients were divided into two groups according to the presence or absence of LVRR. Cardiac events were defined as the occurrence of cardiac death, rehospitalization for worsening heart failure, and mitral valve surgery. RESULTS: On univariable analysis, EuroSCORE II and GLS were associated with LVRR. On multivariable logistic regression analysis, GLS was the only independent correlate of LVRR (P = 0.004). A receiver operating characteristic curve identified a cutoff value for GLS of -9.25% (P < 0.001) associated with LVRR, with a sensitivity and specificity of 81 and 74%, respectively. New York Heart Failure Association class more than 2 after MCi, absence of LVRR after MCi, and preoperative GLS more than -9.25% were significantly correlated with adverse cardiac events at long-term follow-up. On multivariable logistic regression analysis, GLS was the only independent predictor of composite adverse cardiac events at 2-year follow-up. CONCLUSION: A worse preoperative GLS predicts no LVRR and is associated with adverse long-term outcome after successful MCi for SMR. [less ▲]

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See detailImpacts of the Hara Biosphere Reserve on Livelihood and Welfare in Persian Gulf
Dehghani Pour, Milad; Motiee, Naser; Akbar Barati, Ali et al

in Ecological Economics (2017), 141(November 2017), 7686

Despite the importance of biosphere reserves in Iran's livelihood and welfare, the economic significance of Hara Biosphere Reserve has never been comprehensively studied. This study examines the current ... [more ▼]

Despite the importance of biosphere reserves in Iran's livelihood and welfare, the economic significance of Hara Biosphere Reserve has never been comprehensively studied. This study examines the current importance of Hara Biosphere Reserve (HBR) in local livelihood and welfare. Using a household survey, data were collected through a questionnaire, key informant interviews and direct observations. Two hundred and forty-four households were randomly selected from 10 villages through proportional sampling. Results showed that non-environmental income was the first driver of the total income, poverty alleviation and narrowing income inequality gap. Park income was the second. The results also showed that excluding park income from total income would significantly increase headcount poverty, widen the poverty gap, and raise the Gini coefficient. Wealthier households had the greatest absolute income from the environment, including forest, fishing and fodder. However, the poorest group had smallest absolute income from these sources. Thus, the study demonstrated that wealthier households are responsible for the overharvesting of environmental resources. Interestingly, the study showed that wealthier households are more dependent on profitable environmental incomes sources while the poorest are more dependent on non-profitable ones. [less ▲]

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See detailUnderstanding the causes and consequences of past marine carbon cycling variability through models
Hülse, Dominik; Arndt, Sandra; Wilson, Jamie D. et al

in Earth-Science Reviews (2017), 171

On geological time-scales, the production and degree of recycling of biogenic carbon in the marine realm and ultimately its removal to sediments, exerts a dominant control on atmospheric CO2 and hence ... [more ▼]

On geological time-scales, the production and degree of recycling of biogenic carbon in the marine realm and ultimately its removal to sediments, exerts a dominant control on atmospheric CO2 and hence variability in climate. This is a highly complex system involving a myriad of inter-connected biological, chemical, and physical processes. For this reason alone, linking observations, often highly abstracted in the form of proxies, to the primary processes involved and ultimately to explanatory hypotheses for specific geological events and transitions, is challenging. The past few decades have seen a progressive improvement in theoretical and process-based understanding of the various components that make up the marine carbon cycle and, hand-in-hand with this, the development of numerical model representations of the complete system. Models have also been designed and/or adapted with paleoclimate questions in mind and applied to quantitatively explore the role of the marine carbon cycle in both perturbations and long-term geologic evolutionary trends in global climate, and possible feedbacks between them. However, we must ask whether paleoclimate models incorporate sufficiently appropriate representations of the dynamics and sensitivities of the marine carbon cycle, and indeed, whether in the geological context, we really know what these dynamics are. Here we provide a comprehensive overview of how marine carbon cycling and the biological carbon pump is treated in available paleoclimate models, with the aim of critically evaluating their ability to help interpret past marine carbon cycle and climate dynamics. To this end, we first provide an overview of commonly used paleoclimate models and some of their associated paleo-applications, drawing from a wide range of global carbon cycle box models and Earth system Models of Intermediate Complexity (EMICs). Secondly, we review and evaluate the three dominant processes involved in the cycling of organic and inorganic carbon in the marine system and how they are represented in models, namely: biological productivity at the ocean surface, remineralisation/dissolution of particulate carbon within the water column, and the benthic-pelagic coupling at the seafloor. We generate and employ illustrative examples using the model GENIE to show how different parameterisations of water-column and sediment processes can lead to significantly different model projections. Our compilation reveals the prevalence of static parametrisations of marine carbon cycling among existing paleoclimate models, which are commonly empirically derived from present-day observations. Although such approaches tend to represent carbon transfer in the modern ocean well, they are potentially compromised in their ability to reflect the true degree of freedom and strength of feedbacks with respect to past climate events, particularly those characterised by environmental boundary conditions that differ fundamentally from today. Finally, we discuss the importance of using models of different complexities and how questions of model uncertainty may start to be addressed. [less ▲]

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See detailDepth-speci c Fluctuations of gene expression and protein abundance modulate the photophysiology in the seagrass Posidonia oceanica
Procaccini, Gabriele; Ruocco, Miriam; Marin-Guirao, Lazaro et al

in Scientific Reports (2017), 7(42890), 1-14

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light ... [more ▼]

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light environment, at contrasting depths. We assessed changes in photophysiological parameters, leaf respiration, pigments, and protein and mRNA expression levels. The results show that the diel oscillations of P. oceanica photophysiological and respiratory responses were related to transcripts and proteins expression of the genes involved in those processes and that there was a response asynchrony between shallow and deep plants probably caused by the strong di erences in the light environment. The photochemical pathway of energy use was more e ective in shallow plants due to higher light availability, but these plants needed more investment in photoprotection and photorepair, requiring higher translation and protein synthesis than deep plants. The genetic di erentiation between deep and shallow stands suggests the existence of locally adapted genotypes to contrasting light environments. The depth-speci c diel rhythms of photosynthetic and respiratory processes, from molecular to physiological levels, must be considered in the management and conservation of these key coastal ecosystems. [less ▲]

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See detailIntroduction de la section "Varia"
Simons, Germain ULg; Beckers, Jacqueline ULg; De Croix, Séverine et al

in Didactiques en Pratique (2017), 3

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See detailCopper adsorption from wasterwater using bone charcoal
Ghrab, Sana; Benzina, Mourad; Lambert, Stéphanie ULg

in Advances in Materials Physics and Chemistry (2017), 7

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See detailEquivalent to Represent Inertial and Primary Frequency Control Effects of an External System
Weckesser, Johannes ULg; Van Cutsem, Thierry ULg

in IET Generation, Transmission & Distribution (2017)

This paper presents a novel equivalent, which is suitable for simulation of inertial and primary frequency control effects. In the model reduction procedure, dynamic power injectors are used to replace ... [more ▼]

This paper presents a novel equivalent, which is suitable for simulation of inertial and primary frequency control effects. In the model reduction procedure, dynamic power injectors are used to replace the external system and to mimic its dynamic behavior. The parameters of the equivalents are tuned with a simple approach presented in this paper. The effectiveness of the proposed method is demonstrated on a modified version of the ENTSO-E Dynamic Study Model. The results show that the system frequency response of the unreduced system is retained and a speedup of the simulations of around 4.0 is achieved. [less ▲]

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See detailAdaptation response surfaces for managing wheat under perturbed climate and CO2 in a Mediterranean environment
Ruiz-Ramos, M.; Ferrise, R.; Rodríguez, A. et al

in Agricultural Systems (2017)

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See detailNew directions in hypnosis research: strategies for advancing the cognitive and clinical neuroscience of hypnosis
Jensen, Mark P; Jamieson, Graham A; Lutz, Antoine et al

in Neuroscience of Consciousness (2017), 3(1), 1-14

In August of 2015, the International Society of Hypnosis and Confederation Francophone d’hypnose et Therapies Breves co-sponsored a 1-day meeting among hypnosis researchers, just before the International ... [more ▼]

In August of 2015, the International Society of Hypnosis and Confederation Francophone d’hypnose et Therapies Breves co-sponsored a 1-day meeting among hypnosis researchers, just before the International Congress of Hypnosis in Paris, France. One of the goals of the meeting was to discuss the state-of-the- science of hypnosis research from the purview of clinical and cognitive neuroscience. The purpose of this article is to summarize the key issues that were raised during the discussions, including the points of agreement and disagreement among the participants (all of whom are authors on this article). Here we first briefly summarize what we view as (i) the most important research findings and developments in the field during the past two decades and (ii) the most salient challenges facing contemporary hypnosis research. Next, we summarize our discussion concerning directions for future hypnosis research and collaborative endeavors that could expand upon recent advances, ad- dress emerging challenges, and facilitate a reemergence of hypnosis research as a vital field within cognitive and clinical neuroscience. [less ▲]

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See detailAntimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica
Ledoux, Allison ULg; St-Gelais, Alexis; Cieckiewicz, Ewa ULg et al

in Journal of Natural Products (2017), 80(6), 1750-1757

Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1−3, and named Poupartone A−C. The ... [more ▼]

Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1−3, and named Poupartone A−C. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data analysis and MS, whereas calculated and experimental ECD spectra were used to define the absolute configurations. These compounds were active against 3D7 and W2 Plasmodium falciparum strains with IC50 values between 0.55 and 1.81 μM. In vitro cytotoxicity against WI38 human fibroblasts and the human cervical cancer cell line HeLa (WST-1 assay) showed that these compounds were also cytotoxic, but no hemolytic activity was observed for the extract and pure compounds. An in vivo antimalarial assay was performed on the major cyclohexenone using P. berghei-infected mice at a dose of 15 mg/kg/day ip. The assay revealed growth inhibition of 59.1 and 69.5% at days 5 and 7 postinfection, respectively, although some toxicity was observed. Zebrafish larvae were used as a model to determine the type of toxicity, and the results showed cardiac toxicity. The methanol extract was also studied, and it displayed moderate antiplasmodial properties in vitro. This extract contained the known flavonoids, quercetin, 3′-O-hydroxysulfonylquercetin, quercitrin, and isoquercitrin as well as ellagic acid, which showed high to low activity against the 3D7 P. falciparum strain. [less ▲]

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See detailComputing flooding of crossroads with obstacles using a 2D numerical model (Discussion)
Bruwier, Martin ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Research (2017), 55(5), 737-741

Based on an operational 2D shallow-water model, the Authors computed subcritical dividing flow at a three-branch crossroad, considering obstacles located at different positions. The numerical predictions ... [more ▼]

Based on an operational 2D shallow-water model, the Authors computed subcritical dividing flow at a three-branch crossroad, considering obstacles located at different positions. The numerical predictions were compared to observations from Mignot et al. (2013). Two issues are addressed here, related respectively to the efficiency and relevance of the turbulence model, and to the representation of the obstacles in operational flood models. [less ▲]

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See detailBiomarkers Predicting Bone Turnover in the Setting of CKD.
Evenepoel, Pieter; Cavalier, Etienne ULg; D'Haese, Patrick C.

in Current Osteoporosis Reports (2017)

PURPOSE OF THE REVIEW: Impaired bone quality contributes to the increased fracture risk in chronic kidney disease patients. Both low and high turnover bone disease may compromise bone quality. The ... [more ▼]

PURPOSE OF THE REVIEW: Impaired bone quality contributes to the increased fracture risk in chronic kidney disease patients. Both low and high turnover bone disease may compromise bone quality. The question arises whether bone biomarkers may be additive or replace bone histormorphometry for diagnosing the extremes of bone turnover. RECENT FINDINGS: Studies exploring the performance of established and emerging bone biomarkers against histomorphometric assessment of bone turnover are limited and overall yield inconclusive results as to their diagnostic utility. Bone biomarkers, although promising, currently fail to meet the needed diagnostic accuracy to replace bone histomorphometry and thus are not yet ready for clinical use. Bone biomarkers have not only several advantages, but also important limitations such as high biological variability, retention with kidney disease, preanalytical issues, and interassay variability. These important issues must be considered when developing and evaluating bone biomarkers. There is an urgent need for harmonization and standardization of available assays and additional bone biopsy studies. [less ▲]

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See detailMRI follow-up is unnecessary in patients with macroprolactinomas and long-term normal prolactin levels on dopamine agonist treatment.
Eroukhmanoff, J.; Tejedor, I.; Potorac, Iulia ULg et al

in European Journal of Endocrinology (2017), 176(3), 323-328

OBJECTIVE: Both antitumor and antisecretory efficacies of dopamine agonists (DA) make them the first-line treatment of macroprolactinomas. However, there is no guideline for MRI follow-up once prolactin ... [more ▼]

OBJECTIVE: Both antitumor and antisecretory efficacies of dopamine agonists (DA) make them the first-line treatment of macroprolactinomas. However, there is no guideline for MRI follow-up once prolactin is controlled. The aim of our study was to determine whether a regular MRI follow-up was necessary in patients with long-term normal prolactin levels under DA. PATIENTS AND METHODS: We conducted a retrospective multicenter study (Marseille, Paris La Pitie Salpetriere and Nancy, France; Liege, Belgium) including patients with macroprolactinomas (largest diameter: >10 mm and baseline prolactin level: >100 ng/mL) treated by dopamine agonists, and regularly followed (pituitary MRI and prolactin levels) during at least 48 months once normal prolactin level was obtained. RESULTS: In total, 115 patients were included (63 men and 52 women; mean age at diagnosis: 36.3 years). Mean baseline prolactin level was 2224 +/- 6839 ng/mL. No significant increase of tumor volume was observed during the follow-up. Of the 21 patients (18%) who presented asymptomatic hemorrhagic changes of the macroprolactinoma on MRI, 2 had a tumor increase (2 and 7 mm in the largest size). Both were treated by cabergoline (1 mg/week) with normal prolactin levels obtained for 6 and 24 months. For both patients, no further growth was observed on MRI during follow-up at the same dose of cabergoline. CONCLUSION: No significant increase of tumor size was observed in our patients with controlled prolactin levels on DA. MRI follow-up thus appears unnecessary in patients with biologically controlled macroprolactinomas. [less ▲]

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See detailNeomelodica Music: Formal, Informal and Criminal Dimensions of Naples’ Marginalised Entertainment Industry.
Mazzola, Alessandro ULg

in The European Review of Organised Crime (2017), 1(4), 84-105

Neapolitan neomelodica music is popular among listeners in Southern Italy and abroad. Its contents and aesthetic qualities are depicted as a sign of cultural degradation or as an expression of the ... [more ▼]

Neapolitan neomelodica music is popular among listeners in Southern Italy and abroad. Its contents and aesthetic qualities are depicted as a sign of cultural degradation or as an expression of the criminal culture characterising, as the cliché would have it, Naples’ marginalised underclass. The dominant paradigm in journalistic and criminological analyses describes its scene as mostly unprofessional and largely embedded in a mafia-run entertainment circuit through which Camorra members reinforce their popular consensus and economic domination over local communities. The aim of this article is to deconstruct this dominant view by using an ethnographic approach to analyse several case studies of neomelodica music. The pre-existing literature mostly criticises moral and cultural aspects of the phenomenon, while the public debate tends to misinterpretate and underestimate the real dimensions of neomelodica music as a professionally organised and structured cultural business. The unrecognised status of neomelodica music complicates a more articulated view of its political-economic modes of functioning and on the role played by dominant criminal actors in the field. This article concludes that, rather than being a product of an endogenous degenerate local political economy, the informal and illicit aspects of the neomelodica business can be read as the consequence of its marginalisation in the Italian cultural landscape and entertainment industry.The aim of this article is to deconstruct this dominant view by using an ethnographic approach to analyse several case studies of neomelodica music. The pre-existing literature mostly criticises moral and cultural aspects of the phenomenon, while the public debate tends to misinterpretate and underestimate the real dimensions of neomelodica music as a professionally organised and structured cultural business. The unrecognised status of neomelodica music complicates a more articulated view of its political-economic modes of functioning and on the role played by dominant criminal actors in the field. This article concludes that, rather than being a product of an endogenous degenerate local political economy, the informal and illicit aspects of the neomelodica business can be read as the consequence of its marginalisation in the Italian cultural landscape and entertainment industry. [less ▲]

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See detailAntihypertensive and vasorelaxant effects of aqueous extract of Artemisia campestris L. from Eastern Morocco.
Dib, Ikram; Tits, Monique ULg; Angenot, Luc ULg et al

in Journal of Ethnopharmacology (2017), 206

ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia campestris L. (Asteraceae) has many traditional uses, among which treatment of diabetes and hypertension. AIM OF THE STUDY: This study was conducted in order to ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia campestris L. (Asteraceae) has many traditional uses, among which treatment of diabetes and hypertension. AIM OF THE STUDY: This study was conducted in order to confirm the antihypertensive and hypotensive effects of A. campestris L. aqueous extract (AcAE) and to explore the underlying mechanism of action of its vasorelaxant effect, besides the acute toxicity. Also, the chemical composition of AcAE was investigated. MATERIAL AND METHODS: the chemical content of AcAE was determined by using HPLC and NMR techniques. The antihypertensive effect was assessed indirectly by tail-cuff method on L-NAME induced hypertensive rats, while the hypotensive action was monitored intravenously by invasive method on normotensive rats. The vasorelaxant effect and vascular mechanism of action were studied in the presence of antagonists and blockers on aorta isolated from normotensive rats. On the other side, the acute toxicity was studied by oral feeding of extract to the mice. RESULTS: The global phytochemical profile of AcAE reveals the presence of several polyphenols as main components. A. campestris L. infusion was characterized by mono- and di-cinnamoyl compounds, with 3,5-dicaffeoylquinic (isochlorogenic A) acid being the main compound, followed by 5-caffeoylquinic (chlorogenic) acid. Vicenin-2 (apigenin 6,8-di-C-glucoside) appeared to be the most abundant compound among flavonoids. The daily treatment with AcAE at 150mg/Kg/day prevented the installation of hypertension on L-NAME hypertensive rats, and reduced SBP from 172mmHg up to 144mmHg. At the dose 40mg/Kg, AcAE provoked reduction of systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP), without affecting the heart rate. Also, AcAE (10-2-2mg/ml) relaxed the precontracted aorta by 95.8 +/- 1.3%. The denudation and preincubation of aorta with atropine, calmidazolium, L-NAME, hydroxycobalamin, ODQ, 8-RP-Br-PET-cGMP, thapsigargin and verapamil attenuated the vasorelaxant response, while the pre-treatment with 4-AP, TEA, glibenclamide and BaCl2 did not alter this effect. The oral administration of AcAE (0-6g/Kg) reveals no mortality or toxicity. CONCLUSIONS: our study proved that AcAE possess an important antihypertensive, hypotensive and vasorelaxant effect, which is mediated via calmodulin-NO-cGC-PKG pathway, and via inhibition of calcium influx through voltage-operated calcium channels and activation of intracellular calcium mobilization into sarcoplasmic reticulum. Therefore, our findings give first evidence about the traditional use of A. campestris L. as antihypertensive plant. [less ▲]

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See detailNo post-no core approach to restore severely damaged posterior teeth: An up to 10-year retrospective study of documented endocrown cases
BELLEFLAMME, Marcia ULg; Geerts, Sabine ULg; LOUWETTE, Marie ULg et al

in Journal of Dentistry (2017)

Objectives The objectives of the present study were to (1) retrospectively evaluate documented cases of ceramic and composite endocrowns performed using immediate dentin sealing (IDS); (2) correlate ... [more ▼]

Objectives The objectives of the present study were to (1) retrospectively evaluate documented cases of ceramic and composite endocrowns performed using immediate dentin sealing (IDS); (2) correlate failures with clinical parameters such as tooth preparation characteristics and occlusal parameters. Methods 99 documented cases of endocrowns were evaluated after a mean observation period of 44.7 ± 34.6 months. A classification of restorations was established in function of the level of damage of residual tooth tissues after preparation, from 1 to 3. Evaluation was performed according to FDI criteria and endodontic outcomes were analyzed. Occlusal risk factors were examined and fractographic analysis was performed in case of fracture. Results 48.4% of patients were shown to present occlusal risk factors. 75.8% of restorations were Class 3 endocrowns. 56.6% were performed on molars, 41.4% on premolars and 2.0% on canines. 84.8% were performed in lithium-disilicate glass-ceramic and 12.1% in Polymer-Infiltrated Ceramic Network (PICN) material. The survival and success rates of endocrowns were 99.0% and 89.9% respectively, while the 10-year Kaplan-Meier estimated survival and success rates were 98.8% and 54.9% respectively. Ten failures were detected: periodontal disease (n = 3), endocrown debonding (n = 2), minor chipping (n = 2), caries recurrence (n = 2) and major fractures (n = 1). Due to the reduced amount of failures, no statistical correlation could be established with clinical parameters. Conclusions Endocrowns were shown to constitute a reliable approach to restore severely damaged molars and premolars, even in the presence of extensive coronal tissue loss or occlusal risk factors, such as bruxism or unfavorable occlusal relationships. Clinical significance Practitioners should consider the endocrown instead of the post and core approach to restore severely damaged non-vital posterior teeth. This minimally invasive solution reduces the risk of catastrophic failures and is easily performed. The use of IDS procedure and lithium-disilicate glass-ceramic as prosthesis material gave very good results. [less ▲]

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See detailDeciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme
Barroca, M.; Santos, G.; Johansson, B. et al

in Enzyme and Microbial Technology (2017), 96

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See detailSpatial and temporal control of populations, branching ratios, and electronic coherences in LiH by a single one-cycle infrared pulse
Nikodem, Astrid ULg; Levine, R. D.; Remacle, Françoise ULg

in Physical Review. A : General Physics (2017), 95(5), 053404

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See detailAssessment of the Potential Role of Streptomyces in Cave Moonmilk Formation
Maciejewska, Marta; Adam, Delphine; Naomé, Aymeric ULg et al

in Frontiers in Microbiology (2017), 8

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See detailIdentification of sprinkling storage facilities for windblown timber using a GIS-based modeling approach
Riguelle, Simon ULg; Jourez, Benoît ULg; Hebert, Jacques ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21(2),

After catastrophic storm events, the storage of windblown timber is an effective measure for mitigating economic losses in the forest sector by preventing wood decay, protecting stands from secondary ... [more ▼]

After catastrophic storm events, the storage of windblown timber is an effective measure for mitigating economic losses in the forest sector by preventing wood decay, protecting stands from secondary damage, and regulating the timber supply in the middle and long term. In this study, we first propose a GIS-based methodology for identifying suitable sprinkling storage terminals in Wallonia (Belgium). In addition, we suggest an approach for building a coherent regional network as well as methods for selecting and activating terminals within this network after a storm, depending on the severity and distribution of the damage. The GIS-based approach was used to crosscheck technical requirements related to sprinkling storage according to operational and environmental constraints in the Ardenne, which is the most forested sub-region of Wallonia. A three-step process was employed to identify suitable areas. Nine procurement areas were also delineated according to the regional forest inventory plots as a reference for choosing the terminals that should be included in the regional network and activated after the storm. We generated and evaluated 96 scenarios. In the second step, a network of 30 terminals was suggested, which corresponded to a storage capacity of 4 million m³. This network could facilitate the flexibility in the strategic management of storage after huge storms. The procurement area approach also helps addressing routing and transportation issues in a simple way. The GIS approach facilitates the selection of sprinkling storage terminals, but field validation and enhanced collaboration between public and private landowners and forest owners would still be needed. [less ▲]

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See detailDonnées nouvelles sur quelques espèces minérales de Vielsalm et Salmchâteau (Province de Luxembourg, Belgique)
Blondieau, M; Puccio, S; Compère, Philippe ULg et al

in Bulletin de la Société Royale des Sciences de Liège (2017), 86

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See detailThe diplomacy of practitioners: for an ecology of practices about the problem of the coexistence of wind farms and red kites
Melard, François ULg; Stassart, Pierre M ULg

in Environmental Education Research (2017)

Gathering information, comparing points of view, and designing actions in and about problematic situations are no longer purely academic activities. Learning about complex state of a airs is becoming an ... [more ▼]

Gathering information, comparing points of view, and designing actions in and about problematic situations are no longer purely academic activities. Learning about complex state of a airs is becoming an increasingly widely- distributed necessity and practice, including within civil society. We propose to give rst-hand information – as practitioners and members of a citizens’ wind energy co-operative in Belgium – about the problematic and highly controversial coexistence between wind farms and red kite (Milvus milvus). Will be reported the implementation of a community-based management scheme involving active, original practices of collaboration between citizens with local knowledge and skills and experts or scientists in order to produce research and intervention questions, methods, and results that are claimed to be more sustainable. The sustainability challenges are to design and set up in context a local space for collaboration and learning that departs from traditional public regulatory procedures (i.e. impact studies, public information meetings, etc.). However, the outcomes of this collaborative approach remain fragile. We shall argue in this regard that both the Transdisciplinary Environmental Research and the art of diplomacy may be central to the emergence of re exive governance within transition processes that strive to be sustainable. [less ▲]

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See detailTaxonomic significance of variation in sexual condition in Pelekium Mitt. and related genera (Thuidiaceae)
Norhazrina, N.; Patiño, J.; Hedenäs, L. et al

in Journal of Bryology (2017), 39

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See detailTrace metals in PG1159 stars and the first identification of metal line forbidden components in astrophysical sources
Werner, K.; Hoyer, D.; Rauch, T. et al

in Astronomical Society of the Pacific Conference Series (2017), 509

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See detailDes ressources publiques pour les opérateurs privés d'emploi. Les coulisses de l'accompagnement des chômeurs en Belgique francophone
Remy, Céline ULg

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2017), 28

Dans cet article, nous nous intéressons à la prise en charge des chômeurs par les opérateurs privés d’emploi. Les services publics de l’emploi doivent partager le marché de l’accompagnement des demandeurs ... [more ▼]

Dans cet article, nous nous intéressons à la prise en charge des chômeurs par les opérateurs privés d’emploi. Les services publics de l’emploi doivent partager le marché de l’accompagnement des demandeurs d’emploi avec des prestataires de service qui ont, désormais, pour mission d’organiser l’accompagnement et la formation des chômeurs. Des collaborations naissent entre acteurs privés et publiques sous la forme de « partenariats publics-privés », dans une relation de « délégation » de la mission du service public. Cette gestion « mixte » du marché de l’emploi pose question au niveau de la gestion des ressources publiques par les acteurs privés. Notre enquête, réalisée en Belgique francophone, propose de regarder les effets de cette gestion à travers les défis que pose le marché de l’accompagnement des chômeurs. Les résultats mettent en évidence le développement par les acteurs privés de stratégies « clandestines » pour contourner les problèmes rencontrés lors de la collaboration. Nous verrons dans quelle mesure celles-ci ont un effet sur le parcours d’insertion des demandeurs d’emploi ainsi que la manière dont les agents des services partenariats des services publics de l’emploi gèrent ses stratégies. [less ▲]

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See detailAuroral streamer and its role in driving wave-like pre-onset aurora
Yao, Zhonghua ULg; Pu, Z. Y.; Rae, I. J. et al

in Geoscience Letters (2017), 4(1), 8

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See detailParadoxal agriculture or the art of producing more while using less
Mergeai, Guy ULg

in Tropicultura (2017), 35(2), 71-72

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See detailWhen farmers learn through dialog with their practices: A proposal for a theory of action for agricultural trajectories
Brédart, David ULg; Stassart, Pierre M ULg

in Journal of Rural Studies (2017), 53(C), 1-13

Using pragmatic sociology, we studied feed autonomy in mixed livestock-crop farming in the western region of Belgium (Hainaut Province). In this paper we first describe feed autonomy as an innovation ... [more ▼]

Using pragmatic sociology, we studied feed autonomy in mixed livestock-crop farming in the western region of Belgium (Hainaut Province). In this paper we first describe feed autonomy as an innovation structured around the withdrawal of soybeans and corn from cattle rations. In so doing, we approach feed autonomy as an opportunity for farmers to change their relationships with the soil, plants, animals, and other human beings and reconnect harmful situations to their courses of action. We then show (1) how this withdrawal is accompanied by adaptation in breeding practices (through reconfigurations of cognitive processes and practices) and (2) how events that interrupt the farmer's normal course of action require the farmers to develop their attentiveness to, i.e., their abilities to heed various elements to allow for variability and guide their actions. We therefore propose a theory of action in which learning is the result of surprises, of what destabilizes the farmer and raises doubt in her/his mind about her/his practices. To do that, we take inspiration from John Dewey's work and his notion of experience. Our results question the conceptualization of the trajectory that represents the process of change as a series of sequences with the event as a trigger. Indeed, we understand change to be a constant process of adjusting goals and means that is punctuated by events that become events only when attention is given to them. So, the event itself is no longer the trigger, and understanding adaptation in a trajectory's direction hinges more on the attention that is paid to the event. [less ▲]

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See detailLouis van Bodeghem et le choeur de la cathédrale Saint-Lambert de Liège en 1527
Joly, Emmanuel ULg

in Bulletin Monumental (2017), 175(1), 55-58

En 1526 et 1527, Louis van Bodeghem, le maître maçon de Marguerite d'Autriche, régente des Pays-Bas, se rend à deux reprises à Liège pour élaborer un projet de reconstruction du choeur de la cathédrale ... [more ▼]

En 1526 et 1527, Louis van Bodeghem, le maître maçon de Marguerite d'Autriche, régente des Pays-Bas, se rend à deux reprises à Liège pour élaborer un projet de reconstruction du choeur de la cathédrale Saint-Lambert. [less ▲]

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See detailThoracic endovascular aortic repair (TEVAR) in proximal (type A) aortic dissection: Ready for a broader application?
Nienaber, Christoph A.; Sakalihasan, Natzi ULg; Clough, Rachel E. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2017)

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role ... [more ▼]

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role in managing proximal aortic pathologies is unknown-this is important because in proximal (Stanford type A) aortic dissections, 10% to 30% are not accepted for surgery and 30% to 50% are technically amenable for TEVAR. We describe our case series of type A aortic dissections treated by using TEVAR. METHODS: Between year 2009 and 2016, 12 patients with acute, subacute, or chronic type A aortic dissection with the proximal entry tear located between the coronaries and brachiocephalic artery were treated with TEVAR at 3 centers. Various stent-graft configurations were used to seal the proximal entry tear in the ascending aorta under rapid pacing. RESULTS: A total of 12 patients (9 male, 3 female), mean age 81 +/- 7 years, EuroSCORE II 9.1 +/- 4.5, underwent TEVAR for the treatment of type A aortic dissection. Procedural success was achieved in 11 of 12 patients (91.7%). There was 1 minor stroke and 1 intraprocedural death. No additional deaths were reported at 30 days. At 36 months, there were 4 further deaths (all from nonaortic causes). The mean survival of these 4 deceased was 23 months (range 15-36 months). Follow-up computed tomography demonstrated favorable aortic remodeling. CONCLUSIONS: TEVAR is feasible and reveals promising early results in selected patients with type A aortic dissection who are poor candidates for surgical repair. The current iteration of stent-graft technology, however, needs to be adapted to features specific to the ascending aorta. [less ▲]

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See detailThe particle finite element method for the numerical simulation of bird strike
Cerquaglia, Marco Lucio ULg; Deliège, Geoffrey ULg; Boman, Romain ULg et al

in International Journal of Impact Engineering (2017)

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See detailResponse of Jupiter's auroras to conditions in the interplanetary medium as measured by the Hubble Space Telescope and Juno
Nichols, J. D.; Badman, S. V.; Bagenal, F. et al

in Geophysical Research Letters (2017)

We present the first comparison of Jupiter's auroral morphology with an extended, continuous and complete set of near-Jupiter interplanetary data, revealing the response of Jupiter's auroras to the ... [more ▼]

We present the first comparison of Jupiter's auroral morphology with an extended, continuous and complete set of near-Jupiter interplanetary data, revealing the response of Jupiter's auroras to the interplanetary conditions. We show that for ∼1-3 days following compression region onset the planet's main emission brightened. A duskside poleward region also brightened during compressions, as well as during shallow rarefaction conditions at the start of the program. The power emitted from the noon active region did not exhibit dependence on any interplanetary parameter, though the morphology typically differed between rarefactions and compressions. The auroras equatorward of the main emission brightened over ∼10 days following an interval of increased volcanic activity on Io. These results show that the dependence of Jupiter's magnetosphere and auroras on the interplanetary conditions are more diverse than previously thought. [less ▲]

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See detailRe: Prediction of delivery time in second stage of labor using transperineal ultrasound.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULg et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017), 49(5), 663-664

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See detailImpact of the type of dialysis membranes on the circulating concentration of markers of vitamin D metabolism.
Cavalier, Etienne ULg; Torres, Pablo U.; Dubois, Bernard E. et al

in International Journal of Artificial Organs (2017)

INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to ... [more ▼]

INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to-patient inconsistency can be observed in response to the treatment. In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage. MATERIAL AND METHODS: Alb (Cobas), VDBP (R&D) and 25(OH)D (liquid chromatography-tandem mass spectrometry) were measured in 75 patients before and after a 4-hour dialysis session. Ten dialysis membranes were used: FX10, FX80, FX800, BK-2.1F, BG-2.1U, Rexeed 15 A, Rexeed 21 A, TS 1.8 SL and TS 2.1 SL manque la ELISIO 21H. Accordingly, 13 patients were dialyzed with membranes possessing high adsorption and high cut-off properties (BK), 17 with membranes possessing high adsorption but usual cut-off properties (BG) and all the remaining 45 patients with polysufone (PS) membranes with usual adsorptive and cut-off properties. Among these 45 patients treated with PS, we compared those treated by classical dialysis (HD) (n = 14) and hemodiafiltration (HDF) (n = 31). Results were corrected for total extracellular volume to take into consideration the hemoconcentration after dialysis. RESULTS: The 3 analytes showed a decreased concentration after the dialysis session. The decrease of ALB, VDBP and 25(OH)D was similar with the adsorptive (BG) and PS membranes. However, patients treated with adsorptive and high cut-off membrane (BK) presented a significantly higher decrease values of Alb (-9.6%[-15.1; -7.5]), of VDBP (-20.6%[-36.6; -17.2] and 25(OH)D (-17%[-27.3; -12.3]) compared to other membranes (BG and PS).When we limited our study to PS membranes, we did not observe any significant difference between the HD or HDF modalities in the decrease for any of the studied parameters. CONCLUSIONS: A significant loss of Alb, VDBP and 25(OH)D occurs after a dialysis session. This loss is significantly more important when patients are dialyzed with high adsorption and high cut-off dialysis membranes. [less ▲]

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See detailExploring the effects of seismicity on landslides and catchment sediment yield: An Italian case study
Vanmaercke, Matthias ULg; Ardizzone, F.; Rossi, M. et al

in Geomorphology (2017), 278

Recent studies showed that contemporary average catchment sediment yields (SY, [t km− 2 y− 1]) at regional and continental scales are often strongly correlated to spatial patterns of seismic activity ... [more ▼]

Recent studies showed that contemporary average catchment sediment yields (SY, [t km− 2 y− 1]) at regional and continental scales are often strongly correlated to spatial patterns of seismic activity. Nonetheless, we currently have little insights into the mechanisms that explain these correlations. We investigated how spatial patterns of SY in Italy are linked to patterns of seismic activity. For a dataset of 103 Italian catchments with average SY measured over a period of years to decades, we extracted tectonic and none-tectonic variables that potentially explain observed differences in SY. These include proxies for vertical uplift rates and cumulative seismic moments (CSM) associated with historic earthquakes of different ranges of magnitude. Results showed that also across Italy, SY is significantly correlated to seismicity. However, SY showed much stronger correlations with proxies of seismicity relating to small but frequent earthquakes (2 ≤ Mw < 4) than with proxies relating to tectonic uplift or large, potentially landslide-triggering earthquakes (Mw ≥ 4). Analyses of a dataset of about 500,000 landslides across Italy showed very comparable trends: spatial patterns of landslides within similar lithological units generally show a significant positive correlation with CSM of weak but frequent seismicity and generally not with CSM of large earthquakes. These results suggest that, on a decadal time scale and at a regional/continental spatial scale, frequent but relatively weak seismicity may exert a more important geomorphic impact than large earthquake events or tectonic uplift. © 2016 Elsevier B.V. [less ▲]

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See detailInternational endorsement of the ESCEO algorithm for management of knee osteoarthritis in clinical practice
Bruyère, Olivier ULg; Cooper, Cyrus; Cutolo, Maurizio et al

in Seminars in Arthritis & Rheumatism (2017), (Online First),

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See detailSex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure.
van Hemmen, J.; Saris, I. M. J.; Cohen-Kettenis, P. T. et al

in Cerebral cortex (New York, N.Y. : 1991) (2017)

Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the ... [more ▼]

Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extended WM regions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation of WM microstructure, although sex chromosome genes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role. [less ▲]

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See detailDes traces de lithalses sur des replats de la retombée nord de la crête de la Vecquée
Marion, Jean-Marc ULg; Lamberty, Pauline ULg; Ghiette, Pascal et al

in Hautes Fagnes (2017), 83(305 (1° trimestre 2017)), 9-13

Pissart (2009, 2014) produced a map showing the distribution of "fish tanks", traces of lithalses, in Eastern Belgium (Hautes Fagnes) and he insisted on a close relationships with the systematic presence ... [more ▼]

Pissart (2009, 2014) produced a map showing the distribution of "fish tanks", traces of lithalses, in Eastern Belgium (Hautes Fagnes) and he insisted on a close relationships with the systematic presence in the subsoil of the Upper Cambrian rocks (former Revinian), namely: quartzites, quartzophyllades and phyllades. He made of this lithological aspect a fundamental factor, as well as the periglacial climatic conditions, to justify the formation of lithalses in Eastern Belgium. He points out one exception in the Elsenborn military camp, where the Lower Devonian sandstones and silty shales are exposed. The researchs that led to the realization of this map were carried out on the aerial photos made available to researchers and the public, from the 1950s, by the Military Geographical Institute (IGM). In 2015, the Walloon Public Service, through its "WalOnMap" site, has launched digital terrain models generated by LIDAR (Laser Detection and Ranging) images, including the "2013-2014 (Hillshade)" model, which only gives the relief of the ground, irrespective of the vegetation cover, and offers, by this advantage, a potential for prospecting. This one is clearly superior to that of the above-mentioned aerial photos. [less ▲]

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See detailPrevalence of concomitant bone and muscle wasting in elderly women from the SarcoPhAge cohort: preliminary results
Locquet, Médéa ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in Journal of Frailty & Aging (2017), 6(1), 18-23

Background: Recent studies suggest that bone and muscle wasting are closely interconnected. Objective: The aim was of this study is to assess the prevalence of osteoporosis in a population of women ... [more ▼]

Background: Recent studies suggest that bone and muscle wasting are closely interconnected. Objective: The aim was of this study is to assess the prevalence of osteoporosis in a population of women diagnosed with sarcopenia. Participants, setting and design: We analyzed cross-sectional data of women, aged 65 years and above, for whom bone mineral density was available at the time of inclusion in the SarcoPhAge (Sarcopenia and Physical impairment with advancing Age) cohort, an ongoing prospective study with the aim to assess consequences of sarcopenia. Measurements: Muscle strength was evaluated with a hydraulic hand-dynamometer, appendicular lean mass and bone mineral density by Dual-Energy X-Ray Absorptiometry and physical performance by the Short Physical Performance Battery test (SPPB). Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People definition, i.e. a low muscle mass plus either low muscle strength or low physical performance. A bone mineral density T-score equal to or below -2.5SD at the lumbar spine, at the total hip or at the femoral neck was used to define osteoporosis (World Health Organization definition). Results: A total of 126 women aged 74.38±6.32 years were included. Among them, 26 were assessed with sarcopenia (20.6%) and 34 (27.0%) with osteoporosis. There were more osteoporotic women among sarcopenic subjects (46.1%) than among non-sarcopenic subjects (22.0%) (p-value=0.011). A significant lower appendicular lean mass index was observed in osteoporotic women (p-value=0.025). We also observed, in osteoporotic subjects, a lower muscle strength (p-value=0.023). Numerical values of bone mineral density were lower in the sarcopenic population but the differences did not reach the level of statistical significance. Conclusion: Our study demonstrated that muscle mass and strength are lower in patients with osteoporosis. Prospective changes in bone and muscle mass will be investigated during the follow-up of our cohort. [less ▲]

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See detailDétection de l’érosion dans un bassin versant agricole par comparaison d’images multidates acquises par drone
Lisein, Jonahtan; Pineux, Nathalie; Pierrot-Deseilligny, Marc et al

in Revue française de Photogrammétrie et de Télédétection (2017), 213-214(janvier-avril), 133-141

L’émergence des drones comme outils de cartographie rapide, de par leur capacité à répondre à des besoins très spécifiques, offre de nombreuses opportunités aux scientifiques. Par ailleurs, les récentes ... [more ▼]

L’émergence des drones comme outils de cartographie rapide, de par leur capacité à répondre à des besoins très spécifiques, offre de nombreuses opportunités aux scientifiques. Par ailleurs, les récentes évolutions des techniques de photogrammétrie et de vision par ordinateur permettent, à partir de prises de vues aériennes stéréoscopiques, de fournir aux géomorphologues et aux hydrologues des données topographiques à haute résolution (Tarolli, 2014). En effet, les algorithmes d’orientation externe (structure from motion en anglais, Snavely et al. (2008)) permettent la détermination automatique de la position et de l’orientation des prises de vue d’une collection d’images se recouvrant. La corrélation dense automatique permet ensuite, depuis un bloc d’images orientées, de modéliser finement le relief. L’utilisation en géomorphologie de drones pour la modélisation du relief en est encore à ses premiers souffles, mais montre un potentiel très intéressant. La précision des mesures photogrammétriques rivalise en effet avec les relevés LiDAR, pour un coût d’acquisition significativement moins élevé. Cette recherche se focalise sur deux objectifs. Le premier est de déterminer si la précision des mesures photogrammétriques issues d’images acquises avec un mini-drone permet la détection de changement de relief très fin via la comparaison d’acquisitions multi-dates. Le deuxième objectif, plus spécifique, est de déterminer la manière la plus optimale de paramétrer la compensation par faisceaux avec points d’appui au sein de la suite photogrammétrique open-source MICMAC. [less ▲]

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See detailThe Tourist on the farm: a 'muddled' image
Dubois, Charline ULg; Cawley, Mary; Schmitz, Serge ULg

in Tourism Management (2017), 59

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better ... [more ▼]

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better understanding of agritourism, based on evidence in Wallonia (Belgium) and Luxembourg. It does so by studying the image held by four groups of actors: (i) farmers who provide ‘agritourist’ experiences; (ii) promotional organisations; and tourists who both (iii) have and (iv) have not engaged in agritourism. Agritourism is a muddled concept between realities and stakeholder expectations but opportunities exist for targeting particular niche interests. [less ▲]

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See detailVentilation distribution assessed with electrical impedance tomography and the influence of tidal volume, recruitment and positive end-expiratory pressure in isoflurane-anesthetized dogs.
Ambrosio, Aline M.; Carvalho-Kamakura, Tatiana P. A.; Ida, Keila ULg et al

in Veterinary Anaesthesia & Analgesia (2017), 44(2), 254-263

OBJECTIVE: To examine the intrapulmonary gas distribution of low and high tidal volumes (VT) and to investigate whether this is altered by an alveolar recruitment maneuver (ARM) and 5 cmH2O positive end ... [more ▼]

OBJECTIVE: To examine the intrapulmonary gas distribution of low and high tidal volumes (VT) and to investigate whether this is altered by an alveolar recruitment maneuver (ARM) and 5 cmH2O positive end-expiratory pressure (PEEP) during anesthesia. STUDY DESIGN: Prospective randomized clinical study. ANIMALS: Fourteen client-owned bitches weighing 26 +/- 7 kg undergoing elective ovariohysterectomy. METHODS: Isoflurane-anesthetized dogs in dorsal recumbency were ventilated with 0 cmH2O PEEP and pressure-controlled ventilation by adjusting the peak inspiratory pressure (PIP) to achieve a low (7 mL kg-1; n = 7) or a high (12 mL kg-1; n = 7) VT. Ninety minutes after induction (T90), an ARM (PIP 20 cmH2O for 10 seconds, twice with a 10 second interval) was performed followed by the application of 5 cmH2O PEEP for 35 minutes (RM35). The vertical (ventral=0%; dorsal=100%) and horizontal (right=0%; left=100%) center of ventilation (CoV), four regions of interest (ROI) (ventral, central-ventral, central-dorsal, dorsal) identified in electrical impedance tomography images, and cardiopulmonary data were analyzed using two-way repeated measures anova. RESULTS: The low VT was centered in more ventral (nondependent) areas compared with high VT at T90 (CoV: 38.8 +/- 2.5% versus 44.6 +/- 7.2%; p = 0.0325). The ARM and PEEP shifted the CoV towards dorsal (dependent) areas only during high VT (50.5 +/- 7.9% versus 41.1 +/- 2.8% during low VT, p = 0.0108), which was more distributed to the central-dorsal ROI compared with low VT (p = 0.0046). The horizontal CoV was centrally distributed and cardiovascular variables remained unchanged throughout regardless of the VT, ARM, and PEEP. CONCLUSIONS AND CLINICAL RELEVANCE: Both low and high VT were poorly distributed to dorsal dependent regions, where ventilation was improved following the current ARM and PEEP only during high VT. Studies on the role of high VT on pulmonary complications are required. [less ▲]

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See detailLes nouveautés portées par la loi du 17 juin 2016 relative aux marchés publics, en particulier dans les secteurs spéciaux
Cariat, Nicolas; Vrancken, Martin ULg

in Revue du Droit des Industries de Réseau (2017), 1

La contribution offre un bref compte-rendu du nouveau régime mis en place par la loi du 17 juin 2016 relative aux marchés publics, transposant les directives 2014/24 et 2014/25, singulièrement dans les ... [more ▼]

La contribution offre un bref compte-rendu du nouveau régime mis en place par la loi du 17 juin 2016 relative aux marchés publics, transposant les directives 2014/24 et 2014/25, singulièrement dans les secteurs spéciaux. [less ▲]

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See detailPractical identifiability analysis of a minimal cardiovascular system model.
Pironet, Antoine; Docherty, Paul D.; Dauby, Pierre ULg et al

in Computer Methods & Programs in Biomedicine (2017)

BACKGROUND AND OBJECTIVE: Parameters of mathematical models of the cardiovascular system can be used to monitor cardiovascular state, such as total stressed blood volume status, vessel elastance and ... [more ▼]

BACKGROUND AND OBJECTIVE: Parameters of mathematical models of the cardiovascular system can be used to monitor cardiovascular state, such as total stressed blood volume status, vessel elastance and resistance. To do so, the model parameters have to be estimated from data collected at the patient's bedside. This work considers a seven-parameter model of the cardiovascular system and investigates whether these parameters can be uniquely determined using indices derived from measurements of arterial and venous pressures, and stroke volume. METHODS: An error vector defined the residuals between the simulated and reference values of the seven clinically available haemodynamic indices. The sensitivity of this error vector to each model parameter was analysed, as well as the collinearity between parameters. To assess practical identifiability of the model parameters, profile-likelihood curves were constructed for each parameter. RESULTS: Four of the seven model parameters were found to be practically identifiable from the selected data. The remaining three parameters were practically non-identifiable. Among these non-identifiable parameters, one could be decreased as much as possible. The other two non-identifiable parameters were inversely correlated, which prevented their precise estimation. CONCLUSIONS: This work presented the practical identifiability analysis of a seven-parameter cardiovascular system model, from limited clinical data. The analysis showed that three of the seven parameters were practically non-identifiable, thus limiting the use of the model as a monitoring tool. Slight changes in the time-varying function modeling cardiac contraction and use of larger values for the reference range of venous pressure made the model fully practically identifiable. [less ▲]

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See detailSources and fate of antimicrobials in integrated fish-pig and non-integrated tilapia farms
Li, Kang; Liu, Liping; Zhan et al

in Science of the Total Environment (2017), 595

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See detailNew Minerals, Nomenclature and Classification (CNMNC), Newsletter 35. New minerals and nomenclature modifications approved in 2016 and 2017
Halenius, U; Hatert, Frédéric ULg; Pasero, M et al

in European Journal of Mineralogy (2017), 29

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See detailFacies discrimination with electrical resistivity tomography using a probabilistic methodology: Effect of sensitivity and regularization
Hermans, Thomas ULg; Irving, James

in Near Surface Geophysics (2017), 15

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution ... [more ▼]

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution of facies. However, inverted ERT images tend to be grossly smoothed versions of reality because of the regularization of the inverse problem. In this study, we use a probabilistic methodology based upon co-located measurements to assess the utility of ERT to identify hydrofacies in alluvial aquifers. With this methodology, ERT images are interpreted in terms of the probability of belonging to pre-defined hydrofacies. We first analyze through a synthetic study the ability of ERT to discriminate between different facies. As ERT data suffer from a loss of sensitivity with depth, we find that low sensitivity regions are more affected by misclassification. To counteract this effect, we adapt the probabilistic framework to include the spatially varying data sensitivity. We then apply our learning to a field case. For the latter, we consider two different regularization procedures. In contrast to the data sensitivity which affects the facies probability to a limited amount, the regularization can affect the probability maps more considerably because it has a strong influence on the spatial distribution of inverted resistivity. We find that a regularization strategy based on the most realistic prior information tends to offer the most reliable discrimination of facies. Our results confirm the ability of ERT surveys, when properly designed, to detect facies variations in alluvial aquifers. The method can be easily extended to other contexts. [less ▲]

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See detailVers de nouvelles conceptions intégrées du fonctionnement de la mémoire
Bastin, Christine ULg

in Revue de Neuropsychologie (2017), 9(2), 74-76

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See detailAnalogical reasoning in children with specific language impairment: Evidence from a scene analogy task
Krzemien, Magali ULg; Jemel, Boutheina; Maillart, Christelle ULg

in Clinical Linguistics & Phonetics (2017)

Analogical reasoning is a human ability that maps systems of relations. It develops along with relational knowledge, working memory and executive functions such as inhibition. It also maintains a mutual ... [more ▼]

Analogical reasoning is a human ability that maps systems of relations. It develops along with relational knowledge, working memory and executive functions such as inhibition. It also maintains a mutual influence on language development. Some authors have taken a greater interest in the analogical reasoning ability of children with language disorders, specifically those with specific language impairment (SLI). These children apparently have weaker analogical reasoning abilities than their aged-matched peers without language disorders. Following cognitive theories of language acquisition, this deficit could be one of the causes of language disorders in SLI, especially those concerning productivity. To confirm this deficit and its link to language disorders, we use a scene analogy task to evaluate the analogical performance of SLI children and compare them to controls of the same age and linguistic abilities. Results show that children with SLI perform worse than age-matched peers, but similar to language-matched peers. They are more influenced by increased task difficulty. The association between language disorders and analogical reasoning in SLI can be confirmed. The hypothesis of limited processing capacity in SLI is also being considered. [less ▲]

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See detailDesign sensitivity analysis for shape optimization based on the Lie derivative
Kuci, Erin ULg; Henrotte, François ULg; Duysinx, Pierre ULg et al

in Computer Methods in Applied Mechanics & Engineering (2017)

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed ... [more ▼]

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed from differential geometry, shows that sensitivity of a performance function (i.e. any function of the solution of the problem) with respect to a given design variable can be represented mathematically as a Lie derivative, i.e. the derivative of that performance function along a flow representing the continuous shape modification of the geometrical model induced by the variation of the considered design variable. Theoretical formulae to express sensitivity analytically are demonstrated in detail in the paper, and applied to a nonlinear magnetostatic and a linear elastic problem, following both the direct and the adjoint approaches. Following the analytical approach, one linear system of which only the right-hand side needs be evaluated (the system matrix being known already) has to be solved for each of the design variables in the direct approach, or for each performance functions in the adjoint approach. A substantial gain in computation time is obtained this way compared to a finite difference evaluation of sensitivity, which requires solving a second nonlinear system for each design variable. This is the main motivation of the analytical approach. There is some freedom in the definition of the auxiliary flow that represents the shape modification. We present a method that makes benefit of this freedom to express sensitivity locally as a volume integral over a single layer of finite elements connected to both sides of the surfaces undergoing shape modification. All sensitivity calculations are checked with a finite difference in order to validate the analytic approach. Convergence is analyzed in 2D and 3D, with first and second order finite elements. [less ▲]

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See detailCooking Has Variable Effects on the Fermentability in the Large Intestine of the Fraction of Meats, Grain Legumes, and Insects That Is Resistant to Digestion in the Small Intestine in an in Vitro Model of the Pig’s Gastrointestinal Tract
POELAERT, Christine ULg; Despret, Xavier; Sindic, Marianne ULg et al

in Journal of Agricultural and Food Chemistry (2017), 65

This study aimed to evaluate the fermentation in the large intestine of indigestible dietary protein sources from animal, insect, and plant origin using an in vitro model of the pig’s gastrointestinal ... [more ▼]

This study aimed to evaluate the fermentation in the large intestine of indigestible dietary protein sources from animal, insect, and plant origin using an in vitro model of the pig’s gastrointestinal tract. Protein sources were used raw and after a cooking treatment. Results showed that the category of the ingredient (meats, insects, or grain legumes) exerts a stronger impact on enzymatic digestibility, fermentation patterns, and bacterial metabolites such as short-chain fatty acids (SCFA) and hydrogen sulfide (H2S) than the cooking treatment. The digestibility and the fermentation characteristics of insects were more affected by the cooking procedure than the other categories. Per gram of consumed food, ingredients from animal origin, namely, meats and insects, were associated with fewer fermentation end-products (gas, H2S, SCFA) than ingredients from plant origin, which is related to their higher small intestinal digestibility. [less ▲]

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See detailLa délimitation du champ des activités exclusivement sociales dans la jurisprudence de la Cour de justice de l’Union européenne : essai de clarification
Detienne, Quentin ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2017), (1), 331-364

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See detailLes genres médiatiques de l'anticipation: des usages comiques du futur
Stienon, Valérie ULg

in Médias19 (2017)

La petite presse multiplie les usages comiques de la prédiction, tantôt en empruntant ses effets à l’almanach, tantôt en traitant au second degré les marronniers trop familiers, tantôt encore en ... [more ▼]

La petite presse multiplie les usages comiques de la prédiction, tantôt en empruntant ses effets à l’almanach, tantôt en traitant au second degré les marronniers trop familiers, tantôt encore en infléchissant vers la prospective le principe de la revue de fin d’année. Il est fréquent que les petits journaux satiriques feignent d’imaginer les événements à venir sous la forme de « prédictions pour l’année » et de « coups d’œil prophétiques ». Si de telles éphémérides parodiques ne bénéficient pas de la stabilité d’une rubrique spécifique, elles sont toutefois appelées, au siècle suivant, à prendre l’ampleur de numéros complets qui témoignent d’une postérité intéressante (Illustration, Lectures pour tous, VU, Sciences et voyages) et d’une créativité iconotextuelle qui peut aller jusqu’au faux reportage photographique d’anticipation. Cet article propose de cerner dans sa variété une microforme médiatique inhérente à la modernité de la petite presse. D’une part, sa discursivité porte sur des données socioculturelles présentées comme remarquables et novatrices, censées incarner la quintessence de leur époque tout entière tendue vers l’avenir. D’autre part, sa poétique affiche une temporalité méta-médiatique renvoyant aux fonctions rituelles et référentielles du périodique. [less ▲]

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See detailThe Roles of Spinochromes in Four Shallow Water Tropical Sea Urchins and Their Potential as Bioactive Pharmacological Agents.
Brasseur, Lola; Hennebert, Elise; Fievez, Laurence ULg et al

in Marine Drugs (2017), 15(6),

Spinochromes are principally known to be involved in sea urchin pigmentation as well as for their potentially interesting pharmacological properties. To assess their biological role in sea urchin ... [more ▼]

Spinochromes are principally known to be involved in sea urchin pigmentation as well as for their potentially interesting pharmacological properties. To assess their biological role in sea urchin physiology, experiments are undertaken on crude extracts from four species and on four isolated spinochromes in order to test their antibacterial, antioxidant, inflammatory and cytotoxic activities. First, the antibacterial assays show that the use of crude extracts as representatives of antibacterial effects of spinochromes are inaccurate. The assays on purified spinochromes showed a decrease in the growth of four strains with an intensity depending on the spinochromes/bacteria system, revealing the participation of spinochromes in the defense system against microorganisms. Secondly, in the 2,2-diphenyl-1-picrylhydrazyl antioxidant assays, spinochromes show an enhanced activity compared to the positive control. This latter observation suggests their involvement in ultraviolet radiation protection. Third, spinochromes present a pro-inflammatory effect on lipopolysaccharide-stimulated macrophages, highlighting their possible implication in the sea urchin immune system. Finally, cytotoxicity assays based on Trypan blue exclusion, performed in view of their possible future applications as drugs, show a weak cytotoxicity of these compounds against human cells. In conclusion, all results confirm the implication of spinochromes in sea urchin defense mechanisms against their external environment and reveal their potential for pharmacological and agronomical industries. [less ▲]

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See detail3D electrical resistivity tomography of karstified formations using cross-line measurements
Van Hoorde, Maurits; Hermans, Thomas ULg; Dumont, Gaël ULg et al

in Engineering Geology (2017), 220

The acquisition of a full 3D survey on a large area of investigation is difficult, and from a practitioner’s point of view, very costly. In high-resolution 3D surveys, the number of electrodes increases ... [more ▼]

The acquisition of a full 3D survey on a large area of investigation is difficult, and from a practitioner’s point of view, very costly. In high-resolution 3D surveys, the number of electrodes increases rapidly and the total number of electrode combinations becomes very large. In this paper, we propose an innovative 3D acquisition procedure based on the roll-along technique. It makes use of 2D parallel lines with additional cross-line measurements. However, in order to increase the number of directions represented in the data, we propose to use cross-line measurements in several directions. Those cross-line measurements are based on dipole-dipole configurations as commonly used in cross-borehole surveys. We illustrate the method by investigating the subsurface geometry in a karstic environment for a future wind turbine project. We first test our methodology with a numerical benchmark using a synthetic model. Then, we validate it through a field case application to image the 3D geometry of karst features and the top of unaltered bedrock in limestone formations. We analyze the importance of cross-line measuring and analyze their capability for accurate subsurface imaging. The comparison with standard parallel 2D surveys clearly highlighted the added value of the cross-lines measurements to detect those structures. It provides crucial insight in subsurface geometry for the positioning of the future wind turbine foundation. The developed method can provide a useful tool in the design of 3D ERT survey to optimize the amount of information collected within a limited time frame. [less ▲]

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See detailOn a group theoretic generalization of the Morse-Hedlund theorem
Charlier, Emilie ULg; Puzynina, Svetlana; Zamboni, Luca

in Proceedings of the American Mathematical Society (2017), 145(8), 33813394

In their 1938 seminal paper on symbolic dynamics, Morse and Hedlund proved that every aperiodic infinite word contains at least n+ 1 distinct factors of each length n. They further showed that an infinite ... [more ▼]

In their 1938 seminal paper on symbolic dynamics, Morse and Hedlund proved that every aperiodic infinite word contains at least n+ 1 distinct factors of each length n. They further showed that an infinite word has exactly n+ 1 distinct factors of each length n if and only if it is binary, aperiodic and balanced, i.e., it is a Sturmian word. In this paper we obtain a broad generalization of the Morse-Hedlund theorem via group actions. [less ▲]

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See detailTwo new species in the Micarea prasina group from Western Europe
van den Boom, Pieter P. G.; Brand, A. Maarten; Coppins, Brian J. et al

in Lichenologist (2017), 49(1), 13-25

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