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See detailComment améliorer la réussite à l’examen d’anatomie en 1re année de bachelier en médecine? Étude de l’impact d’une activité intégrée dans un dispositif hybride de formation
Ernst, Denise ULg; Van de Poël, Jean-François ULg; Verpoorten, Dominique ULg et al

in Revue Internationale des Technologies en Pédagogie Universitaire = International Journal of Technologies in Higher Education (2015), 11(3), 51-67

The course of “Introduction to Human Anatomy” is part of the curriculum delivered to the undergraduated students (Freshman year) at the Faculty of Medecine of the University of Liege. The course is taught ... [more ▼]

The course of “Introduction to Human Anatomy” is part of the curriculum delivered to the undergraduated students (Freshman year) at the Faculty of Medecine of the University of Liege. The course is taught in a blending learning mode combining traditional intructor-led and e-learning activities. The MCQ 2 test is one of the three components of the final written exam (which consists of 3 MCQtests). This test requires students to recognize and identify the organ’s orientation in cross-sections represented in different spatial views. In our study, we tried to evaluate how the online training exercises provided by the instructors team for that particular ability was appreciated by students and if students benefited from this type of online activities to improve their examination results for MCQ 2 test. Further in our research, we asked student about their perceptions of coherence between the aims, methods and evaluation of our entire system. Then this perception has been compared with the overall score of the exam to look for the present of correlation elements. We observed that the MCQ 2 test results are significantly better for students who practiced the new online exercises and for students having seen the value of this activity. The perception of consistency or coherence between the objectives, methods and assessment is not correlated to the overall score of the student. As conclusion, we can declare that the new learning scenario proposed positively enriches the learning environment for students. It can be easily scaled up for important groups and accessed at any time by users. It focusses on specific objectives, is directly linked to the examination system of the course (MCQ 2) and also allows developing a competence expertise related to their future medical profession. [less ▲]

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See detailA ‘nodeless’ dual superelement formulation for structural and multibody dynamics application to reduction of contact problems
Géradin, Michel ULg; Rixen, Daniel

in International Journal for Numerical Methods in Engineering (2015)

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See detailEctopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.
Xu, Xuewen; Ectors, Fabien ULg; Davis, Erica E. et al

in PloS one (2015), 10(10), 0140594

The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype ... [more ▼]

The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype. +Mat/CLPGPat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep. [less ▲]

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See detailShear banding modelling in cross-anisotropic rocks
Pardoen, Benoît ULg; Seyedi, D.M.; Collin, Frédéric ULg

in International Journal of Solids and Structures (2015), 72

Sedimentary geomaterials such as rocks frequently exhibit cross-anisotropic properties and their behaviour depends on the direction of loading with respect to their microstructure. As far as material ... [more ▼]

Sedimentary geomaterials such as rocks frequently exhibit cross-anisotropic properties and their behaviour depends on the direction of loading with respect to their microstructure. As far as material rupture is concerned, localised deformation in shear band mode appears generally before cracks and material failure. The influence of cross-anisotropy on the shear strain localisation remains an important issue and is investigated in the present study. To do so, a constitutive elastoplastic cross-anisotropic model that includes anisotropy both on the elastic and plastic characteristics is defined. For the plastic part of the model, the anisotropy of a strength parameter is introduced with a microstructure fabric tensor. Then, the fractures are modelled with finite element methods by considering the development of shear strain localisation bands and an enriched model is used to properly reproduce the shear banding. The cross-anisotropy influence on shear banding is studied through numerical applications of small and large-scale geotechnical problems that engender fractures. The two considered applications are a plane-strain biaxial compression test and an underground gallery excavation. The numerical results provide information about the influence of cross-anisotropy on the appearance and development of shear bands. It has been noticed, among other observations, that the material strength vary with the loading direction and that the development and the shape of the excavation fractured zone that develops around a gallery is strongly influenced by the material anisotropy. [less ▲]

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See detailDirect exoplanet detection and characterization using the ANDROMEDA method: Performance on VLT/NaCo data
Cantalloube, F.; Mouillet, D.; Mugnier, L. M. et al

in Astronomy and Astrophysics (2015), 582

Context. The direct detection of exoplanets with high-contrast imaging requires advanced data processing methods to disentangle potential planetary signals from bright quasi-static speckles. Among them ... [more ▼]

Context. The direct detection of exoplanets with high-contrast imaging requires advanced data processing methods to disentangle potential planetary signals from bright quasi-static speckles. Among them, angular differential imaging (ADI) permits potential planetary signals with a known rotation rate to be separated from instrumental speckles that are either statics or slowly variable. The method presented in this paper, called ANDROMEDA for ANgular Differential OptiMal Exoplanet Detection Algorithm is based on a maximum likelihood approach to ADI and is used to estimate the position and the flux of any point source present in the field of view. Aims. In order to optimize and experimentally validate this previously proposed method, we applied ANDROMEDA to real VLT/NaCo data. In addition to its pure detection capability, we investigated the possibility of defining simple and efficient criteria for automatic point source extraction able to support the processing of large surveys. Methods. To assess the performance of the method, we applied ANDROMEDA on VLT/NaCo data of TYC-8979-1683-1 which is surrounded by numerous bright stars and on which we added synthetic planets of known position and flux in the field. In order to accommodate the real data properties, it was necessary to develop additional pre-processing and post-processing steps to the initially proposed algorithm. We then investigated its skill in the challenging case of a well-known target, $\beta$ Pictoris, whose companion is close to the detection limit and we compared our results to those obtained by another method based on principal component analysis (PCA). Results. Application on VLT/NaCo data demonstrates the ability of ANDROMEDA to automatically detect and characterize point sources present in the image field. We end up with a robust method bringing consistent results with a sensitivity similar to the recently published algorithms, with only two parameters to be fine tuned. Moreover, the companion flux estimates are not biased by the algorithm parameters and do not require a posteriori corrections. Conclusions. ANDROMEDA is an attractive alternative to current standard image processing methods that can be readily applied to on-sky data. [less ▲]

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See detailGuided group purchases of energy renovation services and works in deprived urban neighbourhoods
Ruelle, Christine ULg; Teller, Jacques ULg

in Energy Efficiency (2015)

The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this ... [more ▼]

The energy retrofitting of housings is progressing very slowly in Wallonia (Belgium) despite individual fiscal measures and subsidies offered by public authorities to support households engaging in this process. This paper explores the use of a method called ‘Guided Group Purchases’ (GPPs), i.e. an approach combining support, guidance and group purchasing of energy renovation services and works, as a possible method to accelerate the retrofitting of the existing housing stock. It reports on an action research experiment conducted in the context of the Interreg project ‘SUN’ (Sustainable Urban Neighbourhoods). The results of this experiment are quite promising. Within a few months, some 80 energy retrofitting interventions (energy audits or insulation works) were implemented in one neighbourhood of the city of Liège. Our evaluation of the experiment showed that the prospect of achieving cost reductions was one of the main initial expectations of participants to the GGPs. Still the participants rather insisted on other benefits after taking part to the initiative. These benefits were mostly related to the guidance they received, to the facilitation with contractors and to the social dynamics generated by the initiative. Several weaknesses were also identified by participants, like the lack of follow-up during and after the works. Our evaluation also highlighted that the main landlords did not participate in the initiative and that the influence of GGPs on costs was limited to specific types of interventions. Despite observed limitations and possible improvements, such a neighbourhood-based approach certainly constitutes a promising avenue for public authorities to support and accelerate the energy retrofitting of private residential buildings in urban neighbourhoods. [less ▲]

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See detailA lysine cluster in domain II of Bacillus subtilis PBP4a plays a role in the membrane attachment of this C1-PBP
Vanden Broeck, Arnaud; Van Der Heiden, Edwige ULg; Sauvage, Eric ULg et al

in PLoS ONE (2015)

In PBP4a, a Bacillus subtilis class-C1 penicillin-binding protein (PBP), four clustered lysine (K) residues, K86, K114, K119, and K265, protrude from domain II. Replacement of these amino acids with ... [more ▼]

In PBP4a, a Bacillus subtilis class-C1 penicillin-binding protein (PBP), four clustered lysine (K) residues, K86, K114, K119, and K265, protrude from domain II. Replacement of these amino acids with glutamine (Q) residues by site-directed mutagenesis yielded Mut4KQ PBP4a. When produced in Escherichia coli without its predicted Sec-signal peptide, wildtype (WT) PBP4a was found mainly associated with the host cytoplasmic membrane, whereas Mut4KQ PBP4a remained largely unbound. After purification, the capacities of the two proteins to bind to B. subtilis membranes were compared. The results were similar to those obtained in E. coli: in vitro, a much higher percentage of WT PBP4a than of Mut4KQ PBP4a was found to interact with B. subtilis membranes. Immunodetection of PBP4a in B. subtilis membrane extracts revealed that a processed form of this PBP (as indicated by its size) associates with the B. subtilis cytoplasmic membrane. In the absence of any amphiphilic peptide in PBP4a, the crown of positive charges on the surface of domain II is likely responsible for the cellular localization of this PBP and its attachment to the cytoplasmic membrane. [less ▲]

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See detailData Product Specification Proposal for Architectural Heritage Documentation with Photogrammetric Techniques: A Case Study in Brazil
Campos, Mariana; Tommaselli, Antonio; Ivanova, Ivana et al

in Remote Sensing (2015), 7(10), 13337-13363

Photogrammetric documentation can provide a sound database for the needs of architectural heritage preservation. However, the major part of photogrammetric documentation production is not used for ... [more ▼]

Photogrammetric documentation can provide a sound database for the needs of architectural heritage preservation. However, the major part of photogrammetric documentation production is not used for subsequent architectural heritage projects, due to lack of knowledge of photogrammetric documentation accuracy. In addition, there are only a few studies with rigorous analysis of the requirements for photogrammetric documentation of architectural heritage. In particular, requirements focusing on the geometry of the models generated by fully digital photogrammetric processes are missing. Considering these needs, this paper presents a procedure for architectural heritage documentation with photogrammetric techniques based on a previous review of existing standards of architectural heritage documentation. The data product specification proposed was elaborated conforming to ISO 19131 recommendations. We present the procedure with two case studies in the context of Brazilian architectural heritage documentation. Quality analysis of the produced models were performed considering ISO 19157 elements, such as positional accuracy, logical consistency and completeness, meeting the requirements. Our results confirm that the proposed requirements for photogrammetric documentation are viable. [less ▲]

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See detailParameter estimation and inference in dynamic systems described by linear partial differential equations
Frasso, Gianluca ULg; Jeager, Jonathan; Lambert, Philippe ULg

in AStA Advances in Statistical Analysis (2015)

Differential equations (DEs) are commonly used to describe dynamic sys- tems evolving in one (ordinary differential equations or ODEs) or in more than one dimensions (partial differential equations or ... [more ▼]

Differential equations (DEs) are commonly used to describe dynamic sys- tems evolving in one (ordinary differential equations or ODEs) or in more than one dimensions (partial differential equations or PDEs). In real data applications, the para- meters involved in the DE models are usually unknown and need to be estimated from the available measurements together with the state function. In this paper, we present frequentist and Bayesian approaches for the joint estimation of the parameters and of the state functions involved in linear PDEs. We also propose two strategies to include state (initial and/or boundary) conditions in the estimation procedure. We evaluate the performances of the proposed strategy through simulated examples and a real data analysis involving (known and necessary) state conditions. [less ▲]

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See detailWhy is later age at retirement beneficial for cognition? Results from a French population-based study
Grotz, Catherine ULg; Meillon, Céline; Amieva, Hélène et al

in Journal of Nutrition, Health & Aging (2015)

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See detailEffect of Metals, Metalloids and Metallic Nanoparticles on Microalgae Growth and Industrial Product Biosynthesis: A Review
Miazek, Krystian ULg; Iwanek, Waldemar; Remacle, Claire ULg et al

in International Journal of Molecular Sciences (2015), 16

Microalgae are a source of numerous compounds that can be used in many branches of industry. Synthesis of such compounds in microalgal cells can be amplified under stress conditions. Exposure to various ... [more ▼]

Microalgae are a source of numerous compounds that can be used in many branches of industry. Synthesis of such compounds in microalgal cells can be amplified under stress conditions. Exposure to various metals can be one of methods applied to induce cell stress and synthesis of target products in microalgae cultures. In this review, the potential of producing diverse biocompounds (pigments, lipids, exopolymers, peptides, phytohormones, arsenoorganics, nanoparticles) from microalgae cultures upon exposure to various metals, is evaluated. Additionally, different methods to alter microalgae response towards metals and metal stress are described. Finally, possibilities to sustain high growth rates and productivity of microalgal cultures in the presence of metals are discussed. [less ▲]

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See detailRÉGIME ALIMENTAIRE ET STRATÉGIE TROPHIQUE SAISONNIÈRE DE LA LOUTRE D’EUROPE, LUTRA LUTRA, DANS LE MOYEN ATLAS (MAROC)
Libois, Roland ULg; Fareh, Mostafa; Brahimi, Amina et al

in Revue d'Ecologie (La Terre et la Vie) (2015), 70(4), 314-327

To learn more about the adaptability and predation behaviour of the European Otter (Lutra lutra) in semi-arid regions, its diet has been studied in Wadi Beth, a typical river of Middle Atlas (Morocco ... [more ▼]

To learn more about the adaptability and predation behaviour of the European Otter (Lutra lutra) in semi-arid regions, its diet has been studied in Wadi Beth, a typical river of Middle Atlas (Morocco), from its source areas (Azrou) to El Kansera hill reservoir dam. Fecal samples (spraints) were systematically collected from six locations during two annual cycles, a collection per season campaign. The study reveals that the otter’s diet is classic (dominant fish), very typical and characteristic of aquatic ecosystems in arid Mediterranean climate, which is reflected in particular by the singular presence of prey like reptiles. Prey species richness totals more than 18 species. Moreover, the frequency of occurrence and relative abundance of taxa consumed were calculated from 2444 identified prey. Fish represent more than 75 % of the prey (relative abundance) with a very large predominance of 3 species of barbels. The anuran amphibians constitute 15 % of the prey. The rest is accounted for, according their respective importance, by insects, ophidians, a chelonian (Mauremys leprosa), birds, crustaceans and finally small mammals. Over time, the diet changed: in autumn 2010, cichlids, introduced into the river, appeared in the prey consumed. The proportion of prey types abruptly changed: perciforms, rare in spring and summer 2010 (less than 4 % of the prey) increased sevenfold in autumn 2010 (27 %) and then declined in the spring and more in summer 2011. In summer 2011, the proportion of barbels dropped, drastically offset by salmonids and, even more, by amphibians. In summer, the proportion of amphibians and ophidians becomes more important. Site variations are linked to local conditions: presence of ponds, nature of the bottom, slope, speed and flow of the water, etc. Finally, small-sized fish (salmonids and barbels) dominate the diet: 80 % are less than 10 cm. [less ▲]

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See detailThe onset, evolution and magnetic braking of vortex lattice instabilities in nanostructured superconducting films
Adami, Obaïd-Allah ULg; Jelic, Zeljko ULg; Xue, Cun et al

in Physical Review. B : Condensed Matter (2015), 92

In 1976 Larkin and Ovchinnikov [Sov. Phys. JETP 41, 960 (1976)] predicted that vortex matter in superconductors driven by an electrical current can undergo an abrupt dynamic transition from a flux-flow ... [more ▼]

In 1976 Larkin and Ovchinnikov [Sov. Phys. JETP 41, 960 (1976)] predicted that vortex matter in superconductors driven by an electrical current can undergo an abrupt dynamic transition from a flux-flow regime to a more dissipative state at suficiently high vortex velocities. Typically this transition manifests itself as a large voltage jump at a particular current density, so-called instability current density J, which is smaller than the depairing current. By tuning the effective pinning strength in Al fi lms, using an artifi cial periodic pinning array of triangular holes, we show that a unique and well defi ned instability current density exists if the pinning is strong, whereas a series of multiple voltage transitions appear in the relatively weaker pinning regime. This behavior is consistent with time-dependent Ginzburg-Landau simulations, where the multiple-step transition can be unambiguously attributed to the progressive development of vortex chains and subsequently phase-slip lines. In addition, we explore experimentally the magnetic braking e ffects, caused by a thick Cu layer deposited on top of the superconductor, on the instabilities and the vortex ratchet effect. [less ▲]

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See detailAntioxidant phenolic extracts obtained from secondary Tunisian date varieties (Phoenix dactylifera L.) by hydrothermal treatments
Mrabet, Abdessalem ULg; Jiménez-Araujo, Ana; Fernández-Bolaños, Juan et al

in Food Chemistry (2015), 196(2016), 917-924

Three common non-commercial Tunisian date varieties were treated by two thermal systems, obtaining a liquid fraction which was characterized and its antioxidant capacity determined. The concentration of ... [more ▼]

Three common non-commercial Tunisian date varieties were treated by two thermal systems, obtaining a liquid fraction which was characterized and its antioxidant capacity determined. The concentration of total phenols in the three varieties (Smeti, Garen Gazel, and Eguwa) was increased by steam explosion treatment up to 5311, 4680, and 3832 mg/kg of fresh dates, and their antioxidant activity up to 62.5, 46.5 and 43.1 mmol Trolox®/kg of fresh date, respectively. Both thermal treatments increased the content of phenolic acids. Additionally, a long scale study was carried out in a pilot plant, with steam treatment at 140 °C and 160 °C for 30 min. The liquid phase was extracted and fractionated chromatographically using adsorbent or ionic resins. The phenolic profiles were determined for each fraction, yielding fractions with interesting antioxidant activities with EC50 values of up to 0.08 mg/L or values of TEAC of 0.67 mmol Trolox®/g of extract. [less ▲]

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See detailZigzag antiferromagnetic quantum ground state in monoclinic honeycomb lattice antimonates A3Ni2SbO6 (A=Li, Na)
Zvereva, E.A.; Stratan, M.I.; Ovchenkov, Y.A. et al

in Physical Review. B: Condensed Matter and Materials Physics (2015), 92

We present a comprehensive experimental and theoretical study of the electronic and magnetic properties of two quasi-two-dimensional (2D) honeycomb-lattice monoclinic compounds A3Ni2SbO6 (A=Li, Na ... [more ▼]

We present a comprehensive experimental and theoretical study of the electronic and magnetic properties of two quasi-two-dimensional (2D) honeycomb-lattice monoclinic compounds A3Ni2SbO6 (A=Li, Na). Magnetic susceptibility and specific heat data are consistent with the onset of antiferromagnetic (AFM) long range order at low temperatures with Néel temperatures ~ 14 and 16 K for Li3Ni2SbO6 and Na3Ni2SbO6, respectively. The effective magnetic moments of 4.3 Bohr magnetons/f.u. (Li3Ni2SbO6) and 4.4 Bohr magnetons/f.u. (Na3Ni2SbO6) indicate that Ni2+ is in a high-spin configuration (S=1). The temperature dependence of the inverse magnetic susceptibility follows the Curie-Weiss law in the high-temperature region and shows positive values of the Weiss temperature ~ 8 K (Li3Ni2SbO6) and ~12 K (Na3Ni2SbO6) pointing to the presence of non-negligible ferromagnetic interactions, although the system orders AFM at low temperatures. In addition, the magnetization curves reveal a field-induced (spin-flop type) transition below TN that can be related to the magnetocrystalline anisotropy in these systems. These observations are in agreement with density functional theory calculations, which show that both antiferromagnetic and ferromagnetic intralayer spin exchange couplings between Ni2+ ions are present in the honeycomb planes supporting a zigzag antiferromagnetic ground state. Based on our experimental measurements and theoretical calculations we propose magnetic phase diagrams for the two compounds. [less ▲]

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See detailKIC 4768731: a bright long-period roAp star in the Kepler field
Smalley, B.; Niemczura, E.; Murphy, S. J. et al

in Monthly Notices of the Royal Astronomical Society (2015), 452

We report the identification of 61.45 d[SUP]-1[/SUP] (711.2 μHz) oscillations, with amplitudes of 62.6 μmag, in KIC 4768731 (HD 225914) using Kepler photometry. This relatively bright (V = 9.17 ... [more ▼]

We report the identification of 61.45 d[SUP]-1[/SUP] (711.2 μHz) oscillations, with amplitudes of 62.6 μmag, in KIC 4768731 (HD 225914) using Kepler photometry. This relatively bright (V = 9.17) chemically peculiar star with spectral type A5 Vp SrCr(Eu) has previously been found to exhibit rotational modulation with a period of 5.21 d. Fourier analysis reveals a simple dipole pulsator with an amplitude that has remained stable over a 4-yr time span, but with a frequency that is variable. Analysis of high-resolution spectra yields stellar parameters of T[SUB]eff[/SUB] = 8100 ± 200 K, log g = 4.0 ± 0.2, [Fe/H] = +0.31 ± 0.24 and v sin i = 14.8 ± 1.6 km s[SUP]-1[/SUP]. Line profile variations caused by rotation are also evident. Lines of Sr, Cr, Eu, Mg and Si are strongest when the star is brightest, while Y and Ba vary in antiphase with the other elements. The abundances of rare earth elements are only modestly enhanced compared to other roAp stars of similar T[SUB]eff[/SUB] and log g. Radial velocities in the literature suggest a significant change over the past 30 yr, but the radial velocities presented here show no significant change over a period of 4 yr. [less ▲]

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See detailThe far-ultraviolet main auroral emission at Jupiter – Part 2: Vertical emission profile
Bonfond, Bertrand ULg; Gustin, Jacques ULg; Gérard, Jean-Claude ULg et al

in Annales Geophysicae (2015), 33

The aurorae at Jupiter are made up of many different features associated with a variety of generation mechanisms. The main auroral emission, also known as the main oval, is the most prominent of them as ... [more ▼]

The aurorae at Jupiter are made up of many different features associated with a variety of generation mechanisms. The main auroral emission, also known as the main oval, is the most prominent of them as it accounts for approximately half of the total power emitted by the aurorae in the ultraviolet range. The energy of the precipitating electrons is a crucial parameter to characterize the processes at play which give rise to these auroral emissions, and the altitude of the emissions directly depends on this energy. Here we make use of far-UV (FUV) images acquired with the Advanced Camera for Surveys on board the Hubble Space Telescope and spectra acquired with the Space Telescope Imaging Spectrograph to measure the vertical profile of the main emissions. The altitude of the brightness peak as seen above the limb is ~ 400 km, which is significantly higher than the 250 km measured in the post-dusk sector by Galileo in the visible domain. However, a detailed analysis of the effect of hydrocarbon absorption, including both simulations and FUV spectral observations, indicates that FUV apparent vertical profiles should be considered with caution, as these observations are not incompatible with an emission peak located at 250 km. The analysis also calls for spectral observations to be carried out with an optimized geometry in order to remove observational ambiguities. [less ▲]

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See detailThe far-ultraviolet main auroral emission at Jupiter – Part 1: Dawn–dusk brightness asymmetries
Bonfond, Bertrand ULg; Gustin, Jacques ULg; Gérard, Jean-Claude ULg et al

in Annales Geophysicae (2015), 33

The main auroral emission at Jupiter generally appears as a quasi-closed curtain centered around the magnetic pole. This auroral feature, which accounts for approximately half of the total power emitted ... [more ▼]

The main auroral emission at Jupiter generally appears as a quasi-closed curtain centered around the magnetic pole. This auroral feature, which accounts for approximately half of the total power emitted by the aurorae in the ultraviolet range, is related to corotation enforcement currents in the middle magnetosphere. Early models for these currents assumed axisymmetry, but significant local time variability is obvious on any image of the Jovian aurorae. Here we use far-UV images from the Hubble Space Telescope to further characterize these variations on a statistical basis. We show that the dusk side sector is ~ 3 times brighter than the dawn side in the southern hemisphere and ~ 1.1 brighter in the northern hemisphere, where the magnetic anomaly complicates the interpretation of the measurements. We suggest that such an asymmetry between the dawn and the dusk sectors could be the result of a partial ring current in the nightside magnetosphere. [less ▲]

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See detailEvidence for two spatially separated UV continuum emitting regions in the Cloverleaf broad absorption line quasar
Sluse, Dominique ULg; Hutsemekers, Damien ULg; Anguita, T. et al

in Astronomy and Astrophysics (2015), 582

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing ... [more ▼]

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing in gravitationally lensed quasars is one of the few techniques that can test this model, yielding to the measurement of the size and of temperature profile of the accretion disc. We present spectroscopic observations of the gravitationally lensed broad absorption line quasar H1413+117, which reveal partial microlensing of the continuum emission that appears to originate from two separated regions: a microlensed region, corresponding the compact accretion disc; and a non-microlensed region, more extended and contributing to at least 30% of the total UV-continuum flux. Because this extended continuum is occulted by the broad absorption line clouds, it is not associated with the host galaxy, but rather with light scattered in the neighbourhood of the central engine. We measure the amplitude of microlensing of the compact continuum over the rest-frame wavelength range 1000-7000 Å. Following a Bayesian scheme, we confront our measurements to microlensing simulations of an accretion disc with a temperature varying as T ∝ R[SUP]-1/ν[/SUP]. We find a most likely source half-light radius of R[SUB]1/2[/SUB] = 0.61 × 10[SUP]16[/SUP]cm (i.e., 0.002 pc) at 0.18 μm, and a most-likely index of ν = 0.4. The standard disc (ν = 4/3) model is not ruled out by our data, and is found within the 95% confidence interval associated with our measurements. We demonstrate that, for H1413+117, the existence of an extended continuum in addition to the disc emission only has a small impact on the inferred disc parameters, and is unlikely to solve the tension between the microlensing source size and standard disc sizes, as previously reported in the literature. Based on observations made with ESO Telescopes at the Paranal Observatory (Chile). ESO program ID: 386.B-0337.Appendices A and B are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201526832/olm">http://www.aanda.org</A> [less ▲]

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See detailTests of the Planetary Hypothesis for PTFO 8-8695b
Yu, Liang; Winn, Joshua N.; Gillon, Michaël ULg et al

in Astrophysical Journal (2015), 812

The T Tauri star PTFO 8-8695 exhibits periodic fading events that have been interpreted as the transits of a giant planet on a precessing orbit. Here we present three tests of the planet hypothesis. First ... [more ▼]

The T Tauri star PTFO 8-8695 exhibits periodic fading events that have been interpreted as the transits of a giant planet on a precessing orbit. Here we present three tests of the planet hypothesis. First, we sought evidence for the secular changes in light-curve morphology that are predicted to be a consequence of orbital precession. We observed 28 fading events spread over several years and did not see the expected changes. Instead, we found that the fading events are not strictly periodic. Second, we attempted to detect the planet's radiation, based on infrared observations spanning the predicted times of occultations. We ruled out a signal of the expected amplitude. Third, we attempted to detect the Rossiter-McLaughlin effect by performing high-resolution spectroscopy throughout a fading event. No effect was seen at the expected level, ruling out most (but not all) possible orientations for the hypothetical planetary orbit. Our spectroscopy also revealed strong, time-variable, high-velocity Hα and Ca H & K emission features. All these observations cast doubt on the planetary hypothesis, and suggest instead that the fading events represent starspots, eclipses by circumstellar dust, or occultations of an accretion hotspot. [less ▲]

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See detailHalomethyl-cobalt(bis-acetylacetonate) for the controlled synthesis of functional polymers
Demarteau, Jérémy ULg; Kermagoret, Anthony; German, Ian et al

in Chemical Communications (2015), 51(76), 14334-14337

Novel organocobalt complexes featuring weak C–CoL2 bonds (L = acetylacetonate) are prepared and used as sources of halomethyl radicals. They permit the precision synthesis of a-halide functionalized and ... [more ▼]

Novel organocobalt complexes featuring weak C–CoL2 bonds (L = acetylacetonate) are prepared and used as sources of halomethyl radicals. They permit the precision synthesis of a-halide functionalized and telechelic polymers in organic media or in water. Substitution of halide by azide allows derivatization of polymers using the CuAAC click reaction. [less ▲]

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See detailThe K2-ESPRINT Project I: Discovery of the Disintegrating Rocky Planet K2-22b with a Cometary Head and Leading Tail
Sanchis-Ojeda, R.; Rappaport, S.; Pallé, E. et al

in Astrophysical Journal (2015), 812(2), 112

We present the discovery of a transiting exoplanet candidate in the K2 Field-1 with an orbital period of 9.1457 hr: K2-22b. The highly variable transit depths, ranging from ∼0% to 1.3%, are suggestive of ... [more ▼]

We present the discovery of a transiting exoplanet candidate in the K2 Field-1 with an orbital period of 9.1457 hr: K2-22b. The highly variable transit depths, ranging from ∼0% to 1.3%, are suggestive of a planet that is disintegrating via the emission of dusty effluents. We characterize the host star as an M-dwarf with Teff ≃ 3800 K. We have obtained ground-based transit measurements with several 1-m class telescopes and with the GTC. These observations (1) improve the transit ephemeris; (2) confirm the variable nature of the transit depths; (3) indicate variations in the transit shapes; and (4) demonstrate clearly that at least on one occasion the transit depths were significantly wavelength dependent. The latter three effects tend to indicate extinction of starlight by dust rather than by any combination of solid bodies. The K2 observations yield a folded light curve with lower time resolution but with substantially better statistical precision compared with the ground-based observations. We detect a significant “bump” just after the transit egress, and a less significant bump just prior to transit ingress. We interpret these bumps in the context of a planet that is not only likely streaming a dust tail behind it, but also has a more prominent leading dust trail that precedes it. This effect is modeled in terms of dust grains that can escape to beyond the planet's Hill sphere and effectively undergo “Roche lobe overflow,” even though the planet's surface is likely underfilling its Roche lobe by a factor of 2. [less ▲]

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See detailStroboscopic phenomena in superconductors with dynamic pinning landscape
Jelic, Zeljko ULg; Milosevic, Milorad; Van de Vondel, Joris et al

in Scientific Reports (2015), 5

Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain ... [more ▼]

Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain without dissipation. In case of spatially periodic pinning, a clear enhancement of the superconducting critical current arises when commensurability between the vortex configurations and the pinning landscape occurs. With recent achievements in (ultrafast) optics and nanoengineered plasmonics it has become possible to exploit the interaction of light with superconductivity, and create not only spatially periodic imprints on the superconducting condensate, but also temporally periodic ones. Here we show that in the latter case, temporal matching phenomena develop, caused by stroboscopic commensurability between the characteristic frequency of the vortex motion under applied current and the frequency of the dynamic pinning. The matching resonances persist in a broad parameter space, including magnetic field, driving current, or material purity, giving rise to unusual features such as externally variable resistance/impedance and Shapiro steps in current-voltage characteristics. All features are tunable by the frequency of the dynamic pinning landscape. These findings open further exploration avenues for using flashing, spatially engineered, and/or mobile excitations on superconductors, permitting us to achieve advanced functionalities. [less ▲]

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See detailKepler's first view of O-star variability: K2 data of five O stars in Campaign 0 as a proof of concept for O-star asteroseismology
Buysschaert, B.; Aerts, C.; Bloemen, S. et al

in Monthly Notices of the Royal Astronomical Society (2015), 453

We present high-precision photometric light curves of five O-type stars observed with the refurbished Kepler satellite during its Campaign 0. For one of the stars, we also assembled high-resolution ground ... [more ▼]

We present high-precision photometric light curves of five O-type stars observed with the refurbished Kepler satellite during its Campaign 0. For one of the stars, we also assembled high-resolution ground-based spectroscopy with the HERMES spectrograph attached to the 1.2 m Mercator telescope. The stars EPIC 202060097 (O9.5V) and EPIC 202060098 (O7V) exhibit monoperiodic variability due to rotational modulation with an amplitude of 5.6 and 9.3 mmag and a rotation period of 2.63 and 5.03 d, respectively. EPIC 202060091 (O9V) and EPIC 202060093 (O9V:pe) reveal variability at low frequency but the cause is unclear. EPIC 202060092 (O9V:p) is discovered to be a spectroscopic binary with at least one multiperiodic β Cep-type pulsator whose detected mode frequencies occur in the range [0.11, 6.99] d[SUP]-1[/SUP] and have amplitudes between 0.8 and 2.0 mmag. Its pulsation spectrum is shown to be fully compatible with the ones predicted by core-hydrogen burning O-star models. Despite the short duration of some 33 d and the limited data quality with a precision near 100 μmag of these first K2 data, the diversity of possible causes for O-star variability already revealed from campaigns of similar duration by the MOST and CoRoT satellites is confirmed with Kepler. We provide an overview of O-star space photometry and give arguments why future K2 monitoring during Campaigns 11 and 13 at short cadence, accompanied by time-resolved high-precision high-resolution spectroscopy, opens up the possibility of in-depth O-star seismology. [less ▲]

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See detailSpectral Variations of Of?p Oblique Magnetic Rotator Candidates in the Magellanic Clouds
Walborn, Nolan R.; Morrell, Nidia I.; Nazé, Yaël ULg et al

in Astronomical Journal (The) (2015), 150

Optical spectroscopic monitoring has been conducted of two O stars in the SMC and one in the LMC, the spectral characteristics of which place them in the Of?p category, which has been established in the ... [more ▼]

Optical spectroscopic monitoring has been conducted of two O stars in the SMC and one in the LMC, the spectral characteristics of which place them in the Of?p category, which has been established in the Galaxy to consist of oblique magnetic rotators. All of these Magellanic stars show systematic spectral variations typical of the Of?p class, further strengthening their magnetic candidacy to the point of virtual certainty. The spectral variations are related to photometric variations derived from Optical Gravitational Lensing Experiment data by Nazé et al. in a parallel study, which yields rotational periods for two of them. Now circular spectropolarimetry is required to measure their fields, and ultraviolet spectroscopy to further characterize their low-metallicity, magnetically confined winds, in support of hydrodynamical analyses. [less ▲]

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See detailThe Subaru Coronagraphic Extreme Adaptive Optics System: Enabling High-Contrast Imaging on Solar-System Scales
Jovanovic, N.; Martinache, F.; Guyon, O. et al

in Publications of the Astronomical Society of the Pacific (2015), 127

The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is a multipurpose high-contrast imaging platform designed for the discovery and detailed characterization of exoplanetary systems and ... [more ▼]

The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is a multipurpose high-contrast imaging platform designed for the discovery and detailed characterization of exoplanetary systems and serves as a testbed for high-contrast imaging technologies for ELTs. It is a multiband instrument which makes use of light from 600 to 2500 nm, allowing for coronagraphic direct exoplanet imaging of the inner 3λ/D from the stellar host. Wavefront sensing and control are key to the operation of SCExAO. A partial correction of low-order modes is provided by Subaru's facility adaptive optics system with the final correction, including high-order modes, implemented downstream by a combination of a visible pyramid wavefront sensor and a 2000-element deformable mirror. The well-corrected NIR (y-K bands) wavefronts can then be injected into any of the available coronagraphs, including but not limited to the phase-induced amplitude apodization and the vector vortex coronagraphs, both of which offer an inner working angle as low as 1λ/D. Noncommon path, low-order aberrations are sensed with a coronagraphic low-order wavefront sensor in the infrared (IR). Low noise, high frame rate NIR detectors allow for active speckle nulling and coherent differential imaging, while the HAWAII 2RG detector in the HiCIAO imager and/or the CHARIS integral field spectrograph (from mid-2016) can take deeper exposures and/or perform angular, spectral, and polarimetric differential imaging. Science in the visible is provided by two interferometric modules: VAMPIRES and FIRST, which enable subdiffraction limited imaging in the visible region with polarimetric and spectroscopic capabilities respectively. We describe the instrument in detail and present preliminary results both on-sky and in the laboratory. [less ▲]

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See detailHunting for Planets in the HL Tau Disk
Testi, L.; Skemer, A.; Henning, Th et al

in Astrophysical Journal Letters (2015), 812

Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet ... [more ▼]

Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet formation, probably in a gravitationally unstable disk. To test this scenario, we searched for young planets by means of direct imaging in the L‧ band using the Large Binocular Telescope Interferometer mid-infrared camera. At the location of two prominent dips in the dust distribution at ˜70 AU (˜0.″5) from the central star, we reach a contrast level of ˜7.5 mag. We did not detect any point sources at the location of the rings. Using evolutionary models we derive upper limits of ˜10-15 M[SUB]Jup[/SUB] at ≤0.5-1 Ma for the possible planets. With these sensitivity limits we should have been able to detect companions sufficiently massive to open full gaps in the disk. The structures detected at millimeter wavelengths could be gaps in the distributions of large grains on the disk midplane caused by planets not massive enough to fully open the gaps. Future ALMA observations of the molecular gas density profile and kinematics as well as higher contrast infrared observations may be able to provide a definitive answer. [less ▲]

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See detailPrediction of Allogeneic Hematopoietic Stem-Cell Transplantation Mortality 100 Days After Transplantation Using a Machine Learning Algorithm: A European Group for Blood and Marrow Transplantation Acute Leukemia Working Party Retrospective Data Mining Study
SHOUVAL, Roni; LABOPIN, Myriam; BONDI, Ori et al

in Journal of Clinical Oncology (2015), 33(28), 3144-3152

Purpose: Allogeneic hematopoietic stem-cell transplantation (HSCT) is potentiallu curative for acute leukemia (AL), but carries considerable risk. Machine learning algorithms, which are part of the data ... [more ▼]

Purpose: Allogeneic hematopoietic stem-cell transplantation (HSCT) is potentiallu curative for acute leukemia (AL), but carries considerable risk. Machine learning algorithms, which are part of the data mining (DM) approach, may serve for transplantation-related mortality risk prediction. Patients and Methods: This work is a retrospective DM study on a cohort of 28,236 adult HSCT recipients from the AL registry of the European Group for Blood and Marrow Transplantation. The primary objective was prediction of overall mortality (OM) at 100 days after HSCT. Secondary objectives were estimation of nonrelapse mortality, leukemia-free survival, and overall survival at 2 years. Donor, recipient, and procedural characteristics were alalyzed. The alternating decision tree machine learning algorithm was applied for model development on 70 % of the data set and validated on the remaining data. [less ▲]

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See detailLe coût de l'énergie verte en Wallonie 2003-2012
Boccard, Nicolas; Gautier, Axel ULg

in Reflets et Perspectives de la Vie Economique (2015), LIV(1-2), 71-85

In 2003, the Walloon region has installed a tradable green certificate mechanism to support the production of ‘green’ electricity. In this paper, we estimate that the total cost of the mechanism amounts ... [more ▼]

In 2003, the Walloon region has installed a tradable green certificate mechanism to support the production of ‘green’ electricity. In this paper, we estimate that the total cost of the mechanism amounts to 1,871 billion € for the period 2003-2012, corresponding to a support of 107 €/MWh produced, with important differences between production technologies, the solar photovoltaic receiving up to 588 €/MWh. International comparisons indicate that the Walloon mechanism is particularly generous. We also show that the induced carbon savings are extremely costly with an implicit price of avoided CO2 of 425 € per ton. [less ▲]

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See detailMarchés énergétiques en transition : le cas de la Belgique
Agrell, Per; Gautier, Axel ULg

in Reflets et Perspectives de la Vie Economique (2015), LIV(1-2), 5-6

Foreword by Per Agrell and Axel Gautier

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See detailStructure and functioning of the Heart Team: primum non nocere.
Stefanini, Giulio G.; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2015), 48(4), 529-30

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See detailPre-return-to-work medical consultation for low back pain workers. Good practice recommendations based on systematic review and expert consensus
PETIT, Audrey; ROZENBERG, Sylvie; FASSIER, Jean-Baptiste et al

in Annals of Physical and Rehabilitation Medicine (2015), 58(5), 298-304

Objectives The pre-return-to-work medical consultation during sick leave for low back pain (LBP) aims at assessing the worker's ability to resume working without risk for his/her health, and anticipating ... [more ▼]

Objectives The pre-return-to-work medical consultation during sick leave for low back pain (LBP) aims at assessing the worker's ability to resume working without risk for his/her health, and anticipating any difficulties inherent to returning to work and job retention. This article summarizes the good practices guidelines proposed by the French Society of Occupational Medicine (SFMT) and the French National Health Authority (HAS), and published in October 2013. Methods Good practices guidelines developed by a multidisciplinary and independent task force (24 experts) and peer review committee (50 experts) based on a literature review from 1990 to 2012, according to the HAS methodology. Results According to the labour regulations, workers can request a medical consultation with their occupational physician at any time. The pre-return-to-work consultation precedes the effective return-to-work and can be requested by the employee regardless of their sick leave duration. It must be scheduled early enough to: (i) deliver reassuring information regarding risks to the lower back and managing LBP; (ii) evaluate prognostic factors of chronicity and prolonged disability in relations to LBP and its physical, social and occupational consequences in order to implement the necessary conditions for returning to work; (iii) support and promote staying at work by taking into account all medical, social and occupational aspects of the situation and ensure proper coordination between the different actors. Conclusion A better understanding of the pre-return-to-work consultation would improve collaboration and coordination of actions to facilitate resuming work and job retention for patients with LBP [less ▲]

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See detailGeometrical validity of curvilinear pyramidal finite elements
Johnen, Amaury ULg; Geuzaine, Christophe ULg

in Journal of Computational Physics (2015), 299

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See detailBrain stimulation in patients with disorders of consciousness
Thibaut, Aurore ULg; Laureys, Steven ULg

in Principles and Practice of Clinical Research (2015), 1(3),

Background and Aim: There is a long history of brain stimulation in medical science, and it was tested for years trying to treat several neurological diseases. On the other hand, the treatment choices for ... [more ▼]

Background and Aim: There is a long history of brain stimulation in medical science, and it was tested for years trying to treat several neurological diseases. On the other hand, the treatment choices for patients with severe brain injury resulting in disorders of consciousness (DOC) are still limited and research in this field remains challenging. In the current literature, only a few techniques of brain stimulation were studied in this population of patients. This review describes noninvasive techniques, namely transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), which permit to stimulate the brain through the scalp, as well as the current status of deep brain stimulation (DBS) as treatment for patients with DOC. For each technique (i.e. TMS, tDCS and DBS) a systematic search on Pubmed was performed including the term “vegetative state” or “minimally conscious state” or “disorders of consciousness” and 16 articles matched the criteria. Conclusion: Currently, repetitive TMS (rTMS) and tDCS studies have shown encouraging results, with transient improvements of behavioral signs of consciousness in patients in minimally conscious state (MCS). DBS showed more impressive and extensive behavioral improvement after the implantation of an electrical stimulator in the thalamus. However, this procedure is riskier and the number of patients who can benefit from this intervention is limited. All these therapeutic approaches are still in their infancy. In the years to follow, controlled clinical studies on potential treatments for patients with DOC should multiply and therapeutic measures should be more accessible, controlled and effective. [less ▲]

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See detailPreliminary assessment for the use of VORIS as a tool for rapid lava flow simulation at Goma Volcano Observatory, Democratic Republic of the Congo
Syavulisembo, A. M.; Havenith, Hans-Balder ULg; Smets, B et al

in Natural Hazards & Earth System Sciences (2015)

Assessment and management of volcanic risk are important scientific, economic, and political issues, especially in densely populated areas threatened by volcanoes. The Virunga volcanic province in the ... [more ▼]

Assessment and management of volcanic risk are important scientific, economic, and political issues, especially in densely populated areas threatened by volcanoes. The Virunga volcanic province in the Democratic Republic of the Congo, with over 1 million inhabitants, has to cope permanently with the threat posed by the active Nyamulagira and Nyiragongo volcanoes. During the past century, Nyamulagira erupted at intervals of 1–4 years – mostly in the form of lava flows – at least 30 times. Its summit and flank eruptions lasted for periods of a few days up to more than 2 years, and produced lava flows sometimes reaching distances of over 20 km from the volcano. Though most of the lava flows did not reach urban areas, only impacting the forests of the endangered Virunga National Park, some of them related to distal flank eruptions affected villages and roads. In order to identify a useful tool for lava flow hazard assessment at Goma Volcano Observatory (GVO), we tested VORIS 2.0.1 (Felpeto et al., 2007), a freely available software (http://www.gvb-csic.es) based on a probabilistic model that considers topography as the main parameter controlling the lava flow propagation. We tested different parameters and digital elevation models (DEM) – SRTM1, SRTM3, and ASTER GDEM – to evaluate the sensitivity of the models to changes in input parameters of VORIS 2.0.1. Simulations were tested against the known lava flows and topography from the 2010 Nyamulagira eruption. The results obtained show that VORIS 2.0.1 is a quick, easy-to-use tool for simulating lava-flow eruptions and replicates to a high degree of accuracy the eruptions tested when input parameters are appropriately chosen. In practice, these results will be used by GVO to calibrate VORIS for lava flow path forecasting during new eruptions, hence contributing to a better volcanic crisis management. [less ▲]

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See detailGlobal capacity announcement of electrical distribution systems: A pragmatic approach
Cornélusse, Bertrand ULg; Vangulick, David; Glavic, Mevludin ULg et al

in Sustainable Energy, Grids and Networks (2015), 4

We propose a pragmatic procedure to facilitate the connection process of Distributed Generation (DG) with reference to the European regulatory framework where Distribution System Operators (DSOs) are ... [more ▼]

We propose a pragmatic procedure to facilitate the connection process of Distributed Generation (DG) with reference to the European regulatory framework where Distribution System Operators (DSOs) are, except in specific cases, not allowed to own their generation. The procedure is termed Global Capacity ANnouncement (GCAN) and is intended to compute the estimates of maximum generation connection amount at appropriate substations in a distribution system, to help generation connection decisions. The pragmatism of the proposed procedure stems from its reliance on the tools that are routinely used in distribution systems planning and operation, and their use such that the possibilities of network sterilization are avoided. The tools involved include: long-term load forecasting, long-term planning of network extension/reinforcement, network reconfiguration, and power flow. Network sterilizing substations are identified through repeated power flow computations. The proposed procedure is supported by results using an artificially created 5-bus test system, the IEEE 33-bus test system, and a part of real-life distribution system of ORES (a Belgian DSO serving a large portion of the Walloon region in Belgium). [less ▲]

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See detailLymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.
Fernandes, Monica T.; Ghezzo, Marinella N.; Silveira, Andre B. et al

in British journal of haematology (2015)

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we ... [more ▼]

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we show that the genes encoding lymphotoxin (LT)-alpha and LTbeta (LTA, LTB) are expressed in T-ALL patient samples, mostly of the TAL/LMO molecular subtype, and in the TEL-JAK2 transgenic mouse model of cortical/mature T-ALL (Lta, Ltb). In these mice, expression of Lta and Ltb is elevated in early stage T-ALL. Surface LTalpha1 beta2 protein is expressed in primary mouse T-ALL cells, but only in the absence of microenvironmental LTbetaR interaction. Indeed, surface LT expression is suppressed in leukaemic cells contacting Ltbr-expressing but not Ltbr-deficient stromal cells, both in vitro and in vivo, thus indicating that dynamic surface LT expression in leukaemic cells depends on interaction with its receptor. Supporting the notion that LT signalling plays a role in T-ALL, inactivation of Ltbr results in a significant delay in TEL-JAK2-induced leukaemia onset. Moreover, young asymptomatic TEL-JAK2;Ltbr-/- mice present markedly less leukaemic thymocytes than age-matched TEL-JAK2;Ltbr+/+ mice and interference with LTbetaR function at this early stage delayed T-ALL development. We conclude that LT expression by T-ALL cells activates LTbetaR signalling in thymic stromal cells, thus promoting leukaemogenesis. [less ▲]

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See detailPhotorefractive holographic camera for monitoring deformations of MEMS
Georges, Marc ULg; Thizy, Cédric ULg

in Journal of Micro/Nanolithography, MEMS, and MOEMS (2015), 14(4), 041301

We present the development of a holographic interferometer based on dynamic hologram recording with photorefractive crystals of the sillenite family and which is adapted for the observation of MEMS. A ... [more ▼]

We present the development of a holographic interferometer based on dynamic hologram recording with photorefractive crystals of the sillenite family and which is adapted for the observation of MEMS. A compact portable system was already presented in the past and used in various metrology and nondestructive applications on large scattering objects. It was emphasized the great versatility of the instrument which allows high resolution measurements. Here we show the development and achievement of an optical module which can be easily interfaced on the basic instrument, allowing small specular objects observation. Results of deformation of electrically actuated MEMS are shown. [less ▲]

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See detailLes souvenirs définissant le soi dans le trouble dépressif majeur unipolaire : Pourquoi les évoquer durant l’entretien clinique ?
Wagener, Aurélie ULg; Boulanger, Marie ULg; PITCHOT, William ULg et al

in Acta Psychiatrica Belgica (2015), 116(2), 27-34

Unipolar depressed patients can experience a loss of sense of self-continuity. Self-defining memories which are particular autobiographical memories may consist in psychological interventions aiming at ... [more ▼]

Unipolar depressed patients can experience a loss of sense of self-continuity. Self-defining memories which are particular autobiographical memories may consist in psychological interventions aiming at reestablishing the sense of self-continuity. Working on self-defining memories may also help dealing with other psychological difficulties. This article presents the self-defining memories, their characteristics and different psychological interventions which aim is to enhance the quality of these memories. [less ▲]

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See detailDescribing many-body bosonic waveguide scattering with the truncated Wigner method
Dujardin, Julien ULg; Engl, Thomas; Urbina, Juan Diego et al

in Annalen der Physik (2015), 527

We consider quasi-stationary scattering of interacting bosonic matter waves in one-dimensional waveguides, as they arise in guided atom lasers. We show how the truncated Wigner (tW) method, which ... [more ▼]

We consider quasi-stationary scattering of interacting bosonic matter waves in one-dimensional waveguides, as they arise in guided atom lasers. We show how the truncated Wigner (tW) method, which corresponds to the semiclassical description of the bosonic many-body system on the level of the diagonal approximation, can be utilized in order to describe such many-body bosonic scattering processes. Special emphasis is put on the discretization of space at the exact quantum level, in order to properly implement the semiclassical approximation and the tW method, as well as on the discussion of the results to be obtained in the continuous limit. [less ▲]

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See detailRepenser la tarifaction de l'énergie
Gautier, Axel ULg

in Reflets et Perspectives de la Vie Economique (2015), LIV(1-2), 175-184

The distribution tariff is for historical reasons connected to the consumption level. Maintaining a tariff per KWh is in our view problematic for two reasons. First, it induces inefficient consumption or ... [more ▼]

The distribution tariff is for historical reasons connected to the consumption level. Maintaining a tariff per KWh is in our view problematic for two reasons. First, it induces inefficient consumption or production choices by consumers. Second, because of scale economies, a decrease in energy consumption leads to both a cost and a revenue decline with the latter being stronger than the former, thereby necessitating an increase in the tariff to compensate for the revenue losses and reinforcing the first effect. The distribution tariff should therefore be re-designed and de-connected, at least partially, from the consumption level. [less ▲]

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See detailNouveaux traitements conservateurs des tendinopathies chroniques
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Revue Médicale de Liège (2015), 70(10), 507-510

The pathophysiological mechanisms of tendinopathies integrate various intrinsic and extrinsic factors. Classic «passive» therapeutics have a limited action. Because of a better pathophysiological ... [more ▼]

The pathophysiological mechanisms of tendinopathies integrate various intrinsic and extrinsic factors. Classic «passive» therapeutics have a limited action. Because of a better pathophysiological understanding of tendinopathies, more recent treatments (injections of various compounds, infiltrations of platelet-rich plasma, stem cells) would lead to a longterm healing. In case of failure of conservative managements and depending on the anatomical site, a surgical approach may be considered. [less ▲]

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See detailPropriété coopérative et acceptabilité sociale de l’éolien terrestre
Bauwens, Thomas ULg

in Reflets et Perspectives de la Vie Economique (2015), LIV(1-2), 59-70

Onshore wind power development in Belgium has provoked considerable opposition at the local level. To cope with this issue, wind power cooperatives seem to present important assets. This article explores ... [more ▼]

Onshore wind power development in Belgium has provoked considerable opposition at the local level. To cope with this issue, wind power cooperatives seem to present important assets. This article explores the reasons why these organizations are likely to enhance social acceptability of this technology. Then it confronts these normative assumptions with empirical data. The results of this analysis confirm the positive effect of cooperative ownership on the social acceptability of onshore wind turbines. [less ▲]

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See detailComment je traite... la reconstruction du nez
RENWART, Ludovic ULg; NIZET, Jean-Luc ULg

in Revue Médicale de Liège (2015), 70(10), 481-485

Les pertes de substance sont une pathologie fréquente en chirurgie plastique, principalement après l'exérèse de cancer de la peau. Les résultats de la reconstruction nasale doivent répondre à des ... [more ▼]

Les pertes de substance sont une pathologie fréquente en chirurgie plastique, principalement après l'exérèse de cancer de la peau. Les résultats de la reconstruction nasale doivent répondre à des exigences esthétiques et fonctionnelles élevées. Une analyse minutieuse de la perte de substance est impérative pour évaluer les déficits anatomiques et esthétiques. Toute perte osseuse, cartilagineuse ou de la muqueuse doit être restaurée. Les lambeaux locaux permettent de couvrir les pertes de substances limitées. Le lambeau frontal est le lambeau de référence pour les plaies complexes. [less ▲]

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See detailLes Mots des Maths : Trapèze
Dupont, Pascal ULg

in Losanges (2015), 30

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See detailL’ÉTUDE CLINIQUE DU MOIS TECOS : confirmation de la sécurité cardiovasculaire de la sitagliptine
SCHEEN, André ULg; PAQUOT, Nicolas ULg

in Revue Médicale de Liège (2015), 70

Summary : The cardiovascular safety of sitagliptin has been evaluated in TECOS («Trial Evaluating Cardiovascular Outcomes with Sitagliptin»). TECOS recruited patients with type 2 diabetes and a history of ... [more ▼]

Summary : The cardiovascular safety of sitagliptin has been evaluated in TECOS («Trial Evaluating Cardiovascular Outcomes with Sitagliptin»). TECOS recruited patients with type 2 diabetes and a history of cardiovascular disease who received, as add-on to their usual therapy, either sitagliptin (n = 7.257) or placebo (n = 7.266), with a median follow-up of 3 years. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95 % confidence interval, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95 % CI, 0.83 to 1.20; P=0.98). The cardiovascular safety of sitagliptin, which was already shown in meta-analyses of phase II-III randomised controlled trials and in observational cohort studies in real life, is now confirmed in the landmark prospective cardiovascular outcome study TECOS. [less ▲]

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See detailAnalyse exploratoire des liens entre l’interaction entraîneur-joueuses, les représentaitons mutuelles de l’entraînement et la performance sportive
Rémy, Elodie; Manfredini, Tiber ULg; Cloes, Marc ULg

in Bulletin de Psychologie (2015), 68(5), 355-366

The coach-athlete relationship is well documented in the literature. Based on an original research model, the study is focused on three female basketball clubs of the 1st regional division in Wallonia ... [more ▼]

The coach-athlete relationship is well documented in the literature. Based on an original research model, the study is focused on three female basketball clubs of the 1st regional division in Wallonia. Combining interviews, participant observation, focus groups, and perception questionnaires, it appears that the relational dynamics of the three sites differs considerably: ‘Back to back’, ‘Above-below’, ‘Inside’. In each case, the coach-players relationship does not seem suitable to the optimal use of the available resources, in order to reach a sport performance in agreement. Courses of actions are suggested for provoking some improvement of the situations. [less ▲]

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See detailHeritability of milk fat composition is considerably lower for Meuse-Rhine-Yssel compared to Holstein Friesian cattle
Maurice-Van Eijndhoven, Myrthe; Veerkamp, Roel; Soyeurt, Hélène ULg et al

in Livestock Science (2015), 180

The aim of this paper is to identify differences in genetic variation of fatty acid (FA) composition in milk in different breeds. Data used included Meuse-Rhine-Yssel (MRY) and Holstein Friesian (HF ... [more ▼]

The aim of this paper is to identify differences in genetic variation of fatty acid (FA) composition in milk in different breeds. Data used included Meuse-Rhine-Yssel (MRY) and Holstein Friesian (HF) cattle breeds which were raised in the Netherlands. Both populations participated in the same milk recording system, but differed in selection history, where in the MRY there has been relatively very little emphasis on selection for high-input high-output production systems compared to HF. Differences in genetic variation were investigated by estimating breed specific additive genetic variances and heritabilities for FA contents in milk of MRY and HF. Mid Infrared Spectrometry spectra were used to predict total fat percentage and detailed FA contents in milk (14 individual FA and 14 groups of FA in g of fat/dL of milk). The dataset for MRY contained 2916 records from 2049 registered cows having at least 50% genes of MRY origin and the dataset used for HF contained 155,319 records from 96,315 registered cows having at least 50% genes of HF origin. Variance components of individual FA content in milk for the different breeds were estimated using a single trait animal model. Additive genetic variances for FA produced through de novo synthesis (short chain FA, C12:0, C14:0, and partly C16:0), C14:1 c-9 and C16:1 c-9 were significantly higher (. P<0.001) for HF compared to MRY. Heritabilities of the individual FA, C4:0 to C18:0, for HF ranged from 0.28 to 0.52 and for MRY from 0.17 to 0.34. Heritabilities of the individual C18 unsaturated FA for HF ranged from 0.11 to 0.34 and for MRY from 0.10 to 0.26. Although the mean content in milk for the FA C18:2 c-9, t-11 was low in both breeds, the additive genetic variance in our dataset was significantly higher for MRY (P<0.05) compared to HF. Heritabilities of the groups of FA for HF ranged from 0.19 to 0.53 and for MRY from 0.11 to 0.28. For the majority of the FA, the additive genetic variances for HF were significantly higher compared to MRY, except for most of the poly-unsaturated FA. The results for the poly-unsaturated FA, however, may be affected by the lower accuracy of the predictions for these FA. In conclusion, our results show that the HF breed has substantially larger genetic variance for most FA compared to MRY. © 2015 Elsevier B.V. [less ▲]

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See detailLatex, un peu, beaucoup (9. Figures & tables)
Dupont, Pascal ULg

in Losanges (2015), 30

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See detailHigh reactive oxygen species in fibrotic and non-fibrotic skin of Patients with diffuse cutaneous systemic sclerosis
BOURJI, Khalil; MEYER, Alain; CHATELUS, Emmanuel et al

in Free Radical Biology & Medicine (2015), 87

Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil the pathogenic ... [more ▼]

Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil the pathogenic mechanisms of SSc, they are still unclear. High levels of Reactive Oxygen Species (ROS) in affected patients have been shown, and ROS are suggested to play a role in fibrosis pathogenesis. In this study we evaluate ROS levels in non-fibrotic and fibrotic skin of patients with SSc and we compare them with those obtained from healthy controls. Patients and Methods We enrolled 9 SSc patients fulfilling the EULAR/ACR classification criteria and 7 healthy controls. Patients included were 4 men and 5 women with mean age of 46 ±10 yrs. Controls were matched by sex and age. All patients were affected by diffuse cutaneous form of SSc and the ANA pattern anti-Scl70. Mean disease duration was 7.5±5 yrs. Skin involvement was evaluated by modified Rodnan Skin Score (mRSS). Skin samples (4 mm punch biopsy) were taken from fibrotic skin and non-fibrotic skin of patients and from healthy controls as well. To detect ROS, specimens were analyzed immediately after sampling by electron paramagnetic resonance spectroscopy. Blood samples have been drawn from all patients and controls to assess oxidative stress biomarkers. Results ROS levels (expressed as median and range, unit of measurement was nmol/l/min/mg of dry weight) were 24.7 (10.9– 47.0) in fibrotic skin, 18.7 (7.3–34.0) in non-fibrotic skin and 7.7 (3.5–13.6) in healthy controls skin. ROS levels in Fibrotic and Non-fibrotic skin of SSc patients were significantly higher than in Healthy Controls (p=0.002 and p=0.009, respectively). ROS levels in fibrotic skin were raised in comparison to non-fibrotic skin, when samples related to each patient were compared (p=0.01). ROS levels in fibrotic skin were correlated with forced vital capacity (r= -0.75, p=0.02) and erythrocyte sedimentation rate (r=0.70, p=0.04). All other clinical and lab parameters showed no significant correlation. When compared to controls, blood from SSc patients showed lower ascorbate (vitamin C) levels (8 [3.8-9.8] vs. 10.5 [9-19.1] mg/L, p=0.004) and higher lipid peroxides (873.5 [342-1973] vs. 422 [105-576] μmol/L, p=0.004). Conclusion Our results indicate the presence of high oxidative stress both in non-fibrotic skin and fibrotic skin of SSc patients, but with higher tendency in the latter. Raised ROS levels in non-fibrotic skin of SSc patients might be a hint of early involvement in skin fibrogenesis. However, a longitudinal prospective study is necessary for such proof. [less ▲]

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See detailLe médicament du mois. Humalog® 200 U/ml KwikPenTM
SCHEEN, André ULg

in Revue Médicale de Liège (2015), 70

Summary : Insulin lispro (Humalog®) was the first short-acting insulin analogue to be indicated for the treatment of diabetes mellitus requiring insulin therapy. After subcutaneous injection, insulin ... [more ▼]

Summary : Insulin lispro (Humalog®) was the first short-acting insulin analogue to be indicated for the treatment of diabetes mellitus requiring insulin therapy. After subcutaneous injection, insulin lispro has a more favourable pharmacokinetics/pharmacodynamics profile than human insulin, characterized by a faster resorption and a more rapid and less prolonged glucose-lowering activity. These properties allow a better control of postprandial hyperglycaemia and a reduction of the risk of delayed hypoglycaemia, especially at night. The patient’s quality of life is also improved because insulin lispro can be injected within the 15 minutes before meal and even possibly after meal when the amount of food intake is unpredictable. Already commercialized as Humalog® 100 U/ml, insulin lispro is now also available as Humalog® 200 U/ml. A pharmacokinetics/pharmacodynamics study confirmed the bioequivalence of the two formulations, based upon the analysis of both plasma free insulin concentrations and glucose infusion rates to maintain normoglycaemia. Humalog® 200 U/ml is available in a novel disposable 3 ml pen (KwikPenTM), with lower glide force and injection volume; thus this new pen is more convenient for the patient compared with the current pen used to inject Humalog® 100 U/ml. The new formulation Humalog® 200 U/ml is indicated in Europe for adult patients with type 1 or type 2 diabetes who require more than 20 units of prandial insulin per day to cover their meals. [less ▲]

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See detailDésobéissance et non-respect des normes juridiques
Garcia Villegas, Mauricio; Lejeune, Aude ULg

in Droit et Société (2015), 91

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See detailA stop-gain in the laminin, alpha 3 gene causes recessive junctional epidermolysis bullosa in Belgian Blue cattle
Sartelet, Arnaud ULg; Harland, Chad ULg; Tamma, Nico ULg et al

in Animal Genetics (2015), 46(5), 566-570

Four newborn purebred Belgian Blue calves presenting a severe form of epidermolysis bullosa were recently referred to our heredo-surveillance platform. SNP array genotyping followed by autozygosity ... [more ▼]

Four newborn purebred Belgian Blue calves presenting a severe form of epidermolysis bullosa were recently referred to our heredo-surveillance platform. SNP array genotyping followed by autozygosity mapping located the causative gene in a 8.3-Mb interval on bovine chromosome 24. Combining information from (i) whole-genome sequencing of an affected calf, (ii) transcriptomic data from a panel of tissues and (iii) a list of functionally ranked positional candidates pinpointed a private G to A nucleotide substitution in the LAMA3 gene that creates a premature stop codon (p.Arg2609*) in exon 60, truncating 22% of the corresponding protein. The LAMA3 gene encodes the alpha 3 subunit of the heterotrimeric laminin-332, a key constituent of the lamina lucida that is part of the skin basement membrane connecting epidermis and dermis layers. Homozygous loss-of-function mutations in this gene are known to cause severe junctional epidermolysis bullosa in human, mice, horse, sheep and dog. Overall, our data strongly support the causality of the identified gene and mutation. [less ▲]

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See detailPrise en charge des patients lombalgiques : les mots du thérapeute aussi importants que ses mains
Demoulin, Christophe ULg; Roussel, Nathalie; Marty, M. et al

in Axxon Exclusif (2015)

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See detailLa cécidomyie orange: repérer les blés qui lui résistent
Chavalle, Sandrine ULg; De Proft, Michel; Jacquemin, Guillaume

in Phytoma : La Défense des Végétaux (2015), 685

Mise au point d’une méthode d’évaluation en conditions contrôlées de la résistance variétale du blé tendre d’hiver à la cécidomyie orange du blé, Sitodiplosis mosellana (Géhin).

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See detailHighlights of the 13th International Conference on Malignant Lymphoma
BONNET, Christophe ULg; BOSLY, A.

in Belgian Journal of Hematology (2015), 6(4), 173-178

A lot of interesting data were presented at the 13th International Conference on Malignant Lymphoma in Lugano, Switzerland. The authors summarise below those presentations/abstracts they found relevant ... [more ▼]

A lot of interesting data were presented at the 13th International Conference on Malignant Lymphoma in Lugano, Switzerland. The authors summarise below those presentations/abstracts they found relevant for daily practice, either now or in the near future. [less ▲]

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See detailSynthesis of aliphatic polyamide bearing fluorinated groups from ε-caprolactam and modified cyclic lysine
Tunc, Deniz; Bouchekiv, Hassen; Améduri, Bruno et al

in European Polymer Journal (2015), 71

Aliphatic polyamide (PA) bearing fluorinated groups was synthesized in bulk with perfluorobutyryl-substituted α-amino-ε-caprolactam and ε-caprolactam by anionic ring-opening polymerization (AROP). The ... [more ▼]

Aliphatic polyamide (PA) bearing fluorinated groups was synthesized in bulk with perfluorobutyryl-substituted α-amino-ε-caprolactam and ε-caprolactam by anionic ring-opening polymerization (AROP). The fluorinated monomer was obtained by condensation between cyclic lysine (i.e. α-amino-ε-caprolactam) and perfluorobutyrylchloride. The effect of the fluorinated monomer fraction onto the AROP of ε-caprolactam was monitored by the exothermicity of this polymerization versus time. The properties and characteristics of the resulting polymers were studied by with differential scanning calorimetry, thermogravimetry, magic angle spining NMR, FT-IR, and contact angle measurements. Polyamides bearing fluorinated groups exhibited better thermal stability than polyamide 6 (PA6) as well as a higher hydrophobic surface character as evidenced by surface tension measurements. The glass transition temperature of polyamide 6 was 53 °C and rose to 58 °C for a PA bearing fluorinated moieties, while fluorinated monomer insertion induced a decrease of the melting points from 216 to 198 °C. These copolymers displayed a maximum degradation temperature of 390 °C as compared to the 310 °C for PA6, and their surface energies decreased from 49.4 mN.cm-1 (PA6 value) to 44.1 mN.cm-1. [less ▲]

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See detailTemporal variability of urinary concentrations of phthalate metabolites, parabens and benzophenone-3 in a belgian adult population
DEWALQUE, Lucas ULg; PIRARD, Catherine ULg; Vandepaer, Sarah et al

in Environmental Research (2015), 142

In the present study, we investigated the temporal within-person variability of the exposure biomarker for phthalates, parabens and benzophenone-3 (BP3) in 32 Belgian adults, each providing 11 urine spots ... [more ▼]

In the present study, we investigated the temporal within-person variability of the exposure biomarker for phthalates, parabens and benzophenone-3 (BP3) in 32 Belgian adults, each providing 11 urine spots during 4 months. We calculated the intraclass coefficient correlation (ICC), the sensitivity and the specificity to assess the temporal reproducibility and to investigate the predictive ability of the spot measurements for these classes of chemicals. Additionally, we explored the temporal variability of the estimation of the cumulative risk of exposure to phthalates (hazard index; HI). We observed fair ICC ranging from 0.55 to 0.68 for parabens, monoethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP) and BP3, but lower ICC, from 0.20 to 0.49, for monobenzyl phthalate (MBzP), mono-n-butyl phthalate (MnBP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxo-hexyl phthalate (5-oxo-MEHP) and mono-2-ethyl-5-hydroxy-hexyl phthalate (5-OH-MEHP). The ICC estimated for HI (0.49) reflected a moderate reproducibility. The measurements in spot samples were moderate to good predictor of the 4-month level of exposure for parabens, MEP, MnBP, MiBP, BP3 and HI (sensitivity ranging from 0.67 to 0.77), but lower predictor for MEHP, 5-oxo-MEHP, 5-OH-MEHP and MBzP (sensitivity ranging from 0.58 to 0.63). The sensitivity could be increased when several spot urinary levels were averaged to predict the long-term level of exposure. Globally, our results indicate that a single spot measurement seems to correctly represent the long-term exposure for parabens, BP3, MEP, MiBP and HI. Additional spot samples seemed to be needed for the proper exposure assessment of the other target compounds. [less ▲]

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See detailLa désobéissance au droit: approche sociologique comparée
Garcia Villegas, Mauricio; Lejeune, Aude ULg

in Droit et Société (2015), 91

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See detailReviews, opinions and insights for future clinical trials: an overview of PPCR journal
Thibaut, Aurore ULg

in Principles and Practice of Clinical Research (2015), 1(3),

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See detailQuelle définition du concept de tangente ? Pour quelles raisons ?
Balhan, Kevin ULg; Krysinska, Marysa; Schneider-Gilot, Marguerite ULg

in Repères : Revue des Instituts de Recherche sur l'Enseignement des Mathématiques (2015), 101(Octobre 2015), 5-32

Dans le présent article, nous présentons un parcours didactique visant à faire évoluer chez les élèves le concept de tangente, de leur connaissance antérieure de tangente à un cercle comme droite ne ... [more ▼]

Dans le présent article, nous présentons un parcours didactique visant à faire évoluer chez les élèves le concept de tangente, de leur connaissance antérieure de tangente à un cercle comme droite ne coupant la courbe qu’en un seul point jusqu’à une définition formalisée au sein d’un cours d’analyse. Nous montrons ainsi qu’une définition d’un objet mathématique n’est ni définitive, ni une simple description de l’objet. Le choix d’une définition au détriment d’une autre doit se faire à la lumière d’un projet plus global relatif à l’institution à laquelle elle appartient. [less ▲]

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See detailRating Network Paths for Locality-Aware Overlay Construction and Routing
Du, Wei; Liao, Yongjun ULg; Tao, Narisu et al

in IEEE/ACM Transactions on Networking (2015), 23(5), 1661-1673

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse ... [more ▼]

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse-grained ratings are appealing in that they are not only informative but also cheap to obtain. Motivated by this insight, we firstly address the scalable acquisition of path ratings by statistical inference. By observing similarities to recommender systems, we examine the applicability of solutions to recommender system and show that our inference problem can be solved by a class of matrix factorization techniques. A technical contribution is an active and progressive inference framework that not only improves the accuracy by selectively measuring more informative paths but also speeds up the convergence for available bandwidth by incorporating its measurement methodology. Then, we investigate the usability of rating-based network measurement and inference in applications. A case study is performed on whether locality awareness can be achieved for overlay networks of Pastry and BitTorrent using inferred ratings. We show that such coarse-grained knowledge can improve the performance of peer selection and that finer granularities do not always lead to larger improvements. [less ▲]

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See detailFunctional identity explains carbon sequestration in a 77-year-old experimental tropical plantation
Bauters, Marijn; Ampoorter, Evy; Huygen, Dries et al

in Ecosphere (2015), 6(10),

Planting forests is an important practice for climate change mitigation, especially in the tropics where the carbon (C) sequestration potential is high. Successful implementation of this mitigation ... [more ▼]

Planting forests is an important practice for climate change mitigation, especially in the tropics where the carbon (C) sequestration potential is high. Successful implementation of this mitigation practice requires knowledge of the role of species identity and diversity on carbon accrual of plantations. Despite this need, solid data on the long-term development of forest plantations are still very scarce. Monospecific and two species mixture plots of a 77-year-old tree diversity experiment in Yangambi in the Congo basin were fully inventoried. We calculated above-ground C stocks using allometric equations, and soil C stocks by analyzing soil samples at multiple depths. Linear mixed effects models were used to analyze the effect of taxonomic and functional identity and diversity on the aboveground and soil carbon stocks. A high variability in aboveground C stocks across tree species combinations was observed. Apart from a species identity effect, the proportion of planted species in the total stand basal area (BApl) and effective species richness were identified as compositional parameters with a significant effect on the aboveground carbon (AGC), with BApl being more important. Both AGC and BApl were coupled to the functional identity of the planted species; the planting of short-lived pioneers led to low AGC. We found no clear benefits, but also no drawbacks, for AGC of two species mixture plots over monospecific plots or including nitrogen fixing species in the plantation scheme. However, the latter was the only compositional parameter with a significant positive effect on the soil carbon stock up to 1 m depth. We conclude that the different plantation configurations gave rise to a wide range in carbon stocks. This was predominantly caused by large differences in AGC sequestration over the past 77 years. Altogether, short-lived pioneer species had a low BApl resulting in low carbon sequestration, while partial shade tolerant species achieved the highest AGC stocks. Tolerating spontaneous ingrowth during the plantation development can further increase the AGC stock, given that the appropriate functional type is planted. [less ▲]

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See detailКомпетентностный подход как основа содержательного обновления образовательных программ высшего профессонального образования в современной России
Duran, Tatyana ULg

in Актуальные проблемы современного образования: опыт и инновации: материалы научно-практической конференции (2015)

L’article justifie que le passage à la troisième génération de normes éducatives de l’Etat a été effectué sur la base des principes du processus de Bologne. Les nouveaux standards éducatifs sont fondés ... [more ▼]

L’article justifie que le passage à la troisième génération de normes éducatives de l’Etat a été effectué sur la base des principes du processus de Bologne. Les nouveaux standards éducatifs sont fondés sur une approche en termes de compétences. Les nouvelles normes éducatives affirment l’approche par compétences comme une approche dominante par rapport à l’organisation du processus de l’éducation et à l’évaluation des résultats. [less ▲]

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See detailCompte rendu de P. Funke, M. Haake, Greek Federal States and Their Sanctuaries
Pirenne-Delforge, Vinciane ULg

in Bryn Mawr Classical Review [=BMCR] (2015)

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See detailEyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
Vanvinckenroye, Amaury ULg; Vandewalle, Gilles ULg; Phillips, Christophe ULg et al

in Neural Plasticity (2015)

Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by ... [more ▼]

Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscillations shape cortical function in time and space. On a much longer time scale, brain function also depends on prior sleep-wake history and circadian processes. However,much remains to be established on how the brain operates at the neuronal level in humans during sleep and wakefulness. A key limitation of human neuroscience is the difficulty in isolating neuronal excitation/inhibition drive in vivo. Therefore, computational models are noninvasive approaches of choice to indirectly access hidden neuronal states. In this review, we present a physiologically driven in silico approach, Dynamic Causal Modelling (DCM), as a means to comprehend brain function under different experimental paradigms. Importantly, DCM has allowed for the understanding of how brain dynamics underscore brain plasticity, cognition, and different states of consciousness. In a broader perspective, noninvasive computational approaches, such as DCM, may help to puzzle out the spatial and temporal dynamics of human brain function at different behavioural states. [less ▲]

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See detailFrom parents to siblings and peers: The wonderful story of social development.
Roskam, Isabelle; Stievenart, Marie ULg; Meunier, Jean-Christophe

in SAGE Open (2015)

The objective of the current research was to test the hypotheses arising from the epigenetic view of social development and from the wider perspective offered by the social network model with three ... [more ▼]

The objective of the current research was to test the hypotheses arising from the epigenetic view of social development and from the wider perspective offered by the social network model with three interactional systems, that is, child–parent, child–sibling, and child–peer. They were tested in two prospective longitudinal studies using a multi-informant and multimethod strategy. Study 1 was conducted among 83 children and their parents and Study 2 among 190 children. Attachment security with parents was assessed when the children were 4 years of age, relationships with siblings at 5 years of age, and relationships with peers at 6 years of age. Attachment to parent was found to explain a limited part of variations in later social relationships with siblings and peers. The sibling interactional system had a consistent and enduring effect on later peer relationships. With regard to the two theoretical backgrounds under consideration, neither was able to account for equivocal findings displayed in the two studies as well as in previous research. The wonderful story of social development seems to be a very complex process for which new models are needed. [less ▲]

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See detailComme un air de rentrée
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2015), 58

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See detailEnzymatic functionalization of a nanobody using protein insertion technology
Crasson, Oscar ULg; Rhazi, Noureddine; Jacquin, Olivier et al

in Protein Engineering, Design & Selection (2015), 28(10), 451-460

Antibody-based products constitute one of the most attractive biological molecules for diagnostic, medical imagery and therapeutic purposes with very few side effects. Their development has be- come a ... [more ▼]

Antibody-based products constitute one of the most attractive biological molecules for diagnostic, medical imagery and therapeutic purposes with very few side effects. Their development has be- come a major priority of biotech and pharmaceutical industries. Recently, a growing number of modified antibody-based products have emerged including fragments, multi-specific and conjugate antibodies. In this study, using protein engineering, we have functionalized the anti-hen egg-white lysozyme (HEWL) camelid VHH antibody fragment (cAb-Lys3), by insertion into a solvent-exposed loop of the Bacillus licheniformis β-lactamase BlaP. We showed that the generated hybrid protein conserved its enzymatic activity while the displayed nanobody retains its ability to inhibit HEWL with a nanomolar affinity range. Then, we successfully implemented the functionalized cAb-Lys3 in enzyme-linked immunosorbent assay, potentiometric biosensor and drug screening assays. The hybrid protein was also expressed on the surface of phage particles and, in this context, was able to interact specifically with HEWL while the β-lactamase activity was used to monitor phage interactions. Finally, using thrombin-cleavage sites surrounding the permissive insertion site in the β-lactamase, we reported an expression system in which the nanobody can be easily separated from its carrier protein. Altogether, our study shows that insertion into the BlaP β-lactamase consti- tutes a suitable technology to functionalize nanobodies and allowsthe creation of versatile tools that can be used in innovative biotechnological assays. [less ▲]

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See detailUsing kernels and ecological niche modeling to delineate conservation areas in an endangered patch-breeding phenotype
Denoël, Mathieu ULg; Ficetola, Francesco

in Ecological Applications (2015), 25(7), 1922-1931

Efficient delineation of conservation areas is a great challenge in maintaining biodiversity. Kernel density estimators (KDEs) are a powerful tool in this perspective, but they have not been applied at ... [more ▼]

Efficient delineation of conservation areas is a great challenge in maintaining biodiversity. Kernel density estimators (KDEs) are a powerful tool in this perspective, but they have not been applied at the population level on patch-distributed organisms. This would be particularly worthy for species that need broad habitats beyond those where they can be sampled; such as terrestrial lands for pond-breeding amphibians. The aim of this study was to compare different approaches for the identification of suitable areas for conservation: KDE, ecological niche modelling, and a combination of KDE and niche models. Paedomorphosis was chosen as a model system because this is an important form of intraspecific variation that is present in numerous taxa, but geographically localized within species and globally endangered. 277 ponds were sampled in one of the hotspots of paedomorphosis to determine the abundance and distribution of paedomorphs (i.e. individuals retaining gills at the adult stage) of the palmate newt (Lissotriton helveticus), with emphasis on the connections between the most valuable populations. KDEs gave insights into the surface areas required to balance the maintenance of certain number of connected ponds and the respective number of disjoint areas in which the whole population is divided. The inclusion of barriers in the models helped in accurately designing the limits of the areas to protect. Alone, habitat models were not able to successfully delineate the area to protect, but the integration between terrestrial suitable areas or barriers and KDE allowed an objective identification of areas required for conservation. Overall, the best performance was observed by the KDE integrating ecological barriers, and by the combination between KDE and niche modelling. In a broader perspective, KDEs are thus a pertinent tool in providing quantitative spatial measurements to delineate conservation areas based on patch-abundance data with a specific focus to connectivity. [less ▲]

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See detailA classification of barycentrically associative polynomial functions
Marichal, Jean-Luc; Mathonet, Pierre ULg; Tomaschek, Jörg

in Aequationes Mathematicae (2015), 89(5), 1281-1291

We describe the class of polynomial functions which are barycentrically associative over an infinite commutative integral domain.

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See detailIdentifying codes in vertex-transitive graphs and strongly regular graphs
Gravier, Sylvain; Parreau, Aline; Rottey, Sara et al

in Electronic Journal of Combinatorics (2015), 22(4), 46

We consider the problem of computing identifying codes of graphs and its fractional relaxation. The ratio between the size of optimal integer and fractional solutions is between 1 and 2ln(|V|)+1 where V ... [more ▼]

We consider the problem of computing identifying codes of graphs and its fractional relaxation. The ratio between the size of optimal integer and fractional solutions is between 1 and 2ln(|V|)+1 where V is the set of vertices of the graph. We focus on vertex-transitive graphs for which we can compute the exact fractional solution. There are known examples of vertex-transitive graphs that reach both bounds. We exhibit infinite families of vertex-transitive graphs with integer and fractional identifying codes of order |V|^α with α∈{14,13,25}. These families are generalized quadrangles (strongly regular graphs based on finite geometries). They also provide examples for metric dimension of graphs. [less ▲]

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See detailL’immunisation des normes législatives par le choix du constituant
Bouhon, Frédéric ULg

in Revue de la Faculté de Droit de l'Université de Liège (2015), 2015/3

Cet article commente l'arrêt n° 81/2015 de la Cour constitutionnelle et se focalise sur la notion de 'choix du constituant' à laquelle la Cour se réfère dans cet arrêt et dans d'autres qui l'ont précédé.

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See detailSequential decision-making approach for quadrangular mesh generation
Johnen, Amaury ULg; Ernst, Damien ULg; Geuzaine, Christophe ULg

in Engineering with Computers (2015), 31(4), 729-735

A new indirect quadrangular mesh generation algorithm which relies on sequential decision-making techniques to search for optimal triangle recombinations is presented. In contrast to the state-of-art ... [more ▼]

A new indirect quadrangular mesh generation algorithm which relies on sequential decision-making techniques to search for optimal triangle recombinations is presented. In contrast to the state-of-art Blossom-quad algorithm, this new algorithm is a good candidate for addressing the 3D problem of recombining tetrahedra into hexahedra. [less ▲]

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See detailA performance indicator for structures under natural fire
Gernay, Thomas ULg; Franssen, Jean-Marc ULg

in Engineering Structures (2015), 100

Fires in buildings are characterized by a heating phase followed by a cooling phase, yet the effects of the latter on structures are not well covered in the current approaches to structural fire ... [more ▼]

Fires in buildings are characterized by a heating phase followed by a cooling phase, yet the effects of the latter on structures are not well covered in the current approaches to structural fire engineering. Indeed the actual requirement of non-occurrence of structural failure at peak temperature does not guarantee against a delayed failure during or after the cooling phase of a fire, which puts at risk the fire brigades and people proceeding to a building inspection after a fire. Therefore there is an urgent need to better comprehend and characterize the materials and structures behavior under decreasing temperatures. Sensitivity to delayed failure of a structural component depends on its typology and constituting materials. In particular, two structural components with the same Fire Resistance rating (R) under standardized fire may exhibit very distinct behavior under natural fire, one of them being more prone to delayed failure than the other. With the aim of quantifying this effect, a new indicator is proposed that characterizes the performance of structures under natural fire conditions. The paper presents the methodology to derive this new indicator as well as results for different typologies of structural components. Parametric analyses highlight the prime influence of constitutive material and thermal inertia of the element on the post-peak behavior. Used in conjunction with the Fire Resistance rating, it is shown how the new indicator carries additional and significant information for classifying structural systems in terms of their fire performance and propensity to delayed failure. [less ▲]

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See detailFalciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review
Mvumbi, Dieudonné; Kayembe, Jean-Marie; Situakibanza, Hippolyte et al

in Malaria Journal (2015), 14

Background: Malaria cases were estimated to 207 million in 2013. One of the problems of malaria control is the emergence and spread of Plasmodium falciparum strains that become resistant to almost all ... [more ▼]

Background: Malaria cases were estimated to 207 million in 2013. One of the problems of malaria control is the emergence and spread of Plasmodium falciparum strains that become resistant to almost all drugs available. Monitoring drug resistance is essential for early detection and subsequent prevention of the spread of drug resistance by timely changes of treatment policy. This review was performed to gather all data available on P. falciparum molecular resistance in DR Congo, as baseline for future assessments. Methods: The search for this review was undertaken using the electronic databases PubMed and Google Scholar using the terms “malaria”, “Congo”, “resistance”, “molecular”, “antimalarial”, “efficacy”. Articles were classified based on year of collecting, year of publication, sample size and characteristics, molecular markers analysed and polymorphisms detected. Results: Thirteen articles were included and five genes have been analysed in these studies: pfcrt, pfdhps, pfdhfr, pfmdr1 and K13-propeller. The majority of studies included were not representative of the whole country. Conclusion: This systematic review demonstrates the lack of molecular resistance studies in DRC. Only 13 studies were identified in almost 15 years. The MOH must implement a national surveillance system for monitoring malaria drug resistance and this surveillance should be conducted frequently and country-representative. [less ▲]

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See detailGreenhouse gas emissions from livestock production in rural area of Algeria, the case of Chemini (Kabylie)
Moula, Nassim ULg; Salhi, A.; Touazi, L. et al

in Livestock Research for Rural Development (2015), 27(10),

The Algerian agricultural sector faces the challenge to meet the food needs of its population despite low agricultural capacity, resulting in increasing pressure on natural resources. This paper aims to ... [more ▼]

The Algerian agricultural sector faces the challenge to meet the food needs of its population despite low agricultural capacity, resulting in increasing pressure on natural resources. This paper aims to inventory the greenhouse gas (GHG) emissions related to livestock sector in the rural area of Chemini (province of Bejaia), taking into account the emissions due to enteric fermentation, in the form of methane, and manure management, in the form of methane and nitrous oxide. Emissions intensity, expressed in CO2- equivalents (CO2-eq) per kg of edible protein, was included in the study. Ruminants contribute to 94% of livestock GHG emissions and to 53% of protein production, with a large share due to cattle. The main part of emissions is related to enteric fermentation. High-producing cattle present the lowest emission intensity of the ruminant category with 24 kg CO2-eq per kg protein. Chickens produce 2.7% of livestock related emissions but provide 47% of animal protein. It results in low emission intensities whereas important difference is noticed between backyard and industrialized systems (around 21 versus 1 kg CO2-eq per kg protein, respectively). Improvement of animal performance should contribute to mitigate the environmental impact of livestock production in Algeria. [less ▲]

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See detailcompte rendu de : Claudio Faustinelli, Dall’inganno di Ulisse all’arco di Apollo. Sul testo e l’interpretazione di Lucil. 836 M.
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2015), 84

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See detailÉcologie et gestion des espèces multi-usages du genre Erythrophleum (Fabaceae-Caesalpinioideae) en Afrique (synthèse bibliographique)
Gorel, Anaïs ULg; Fayolle, Adeline; Doucet, Jean-Louis ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19

Littérature. Erythrophleum ivorense, E. suaveolens, E. africanum et E. lasianthum diffèrent morphologiquement et sont présentes dans des aires climatiques distinctes. Elles sont héliophiles non pionnières ... [more ▼]

Littérature. Erythrophleum ivorense, E. suaveolens, E. africanum et E. lasianthum diffèrent morphologiquement et sont présentes dans des aires climatiques distinctes. Elles sont héliophiles non pionnières (E. ivorense et E. suaveolens) ou pionnières (E. africanum). La dispersion primaire est ballochore. Les graines présentent une période de dormance et peuvent rester plusieurs années dans le sol. La phénologie est régulière et annuelle. La croissance annuelle moyenne varie entre les espèces, de la plus élevée pour E. ivorense (0,65 cm par an) à la plus faible pour E. africanum (0,16 cm par an). Elles sont largement utilisées dans la médecine traditionnelle. Seules E. ivorense et E. suaveolens sont exploitées pour le bois d’oeuvre et soumises à des normes d’exploitation et des tests sylvicoles. Conclusions. Les données sur l’écologie des espèces du genre Erythrophleum sont globalement mieux renseignées pour E. ivorense et E. suaveolens en raison de leur importance économique. Cette synthèse a permis de mettre en évidence certains manques de connaissances notamment sur la phénologie (relation avec le climat, périodes de fructifications), les diamètres minimums de fructification et les mécanismes de levée de dormance naturelle des graines. Remédier à ces lacunes contribuerait notablement à améliorer les méthodes de gestion des populations de ces espèces. [less ▲]

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See detailLe séisme luxembourgeois du 13 avril 1733: nouvelles recherches.
Knuts, Elisabeth ULg

in Ciel et Terre (2015), 131

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See detailWaldenström's macroglobulinaemia: Belgian Hematology Society guidelines
VAN HENDE, V.; BRON, D.; VAN DEN NESTE, E. et al

in Belgian Journal of Hematology (2015), 6(4), 142-151

Waldenström’s macroglobulinaemia is a B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with demonstration of an IgM monoclonal gammopathy in the blood. This ... [more ▼]

Waldenström’s macroglobulinaemia is a B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with demonstration of an IgM monoclonal gammopathy in the blood. This condition belongs to the lymphoplasmacytic lymphomas as defined by the World Health Organization classification (ICD-0 code 9671/3). Approximately one-fourth of patients are asymptomatic. Clinical features of the symptomatic patients are diverse and may relate to overall disease burden (such as peripheral blood cytopaenias, organomegaly and constitutional symptoms) or may be directly attributable to the IgM paraprotein. The latter include hyperviscosity syndrome, amyloidosis, peripheral neuropathy and cold haemagglutinin. Therapeutic options have traditionally involved alkylating agents, nucleoside analogues, and rituximab, either as single therapy or in combination. However, emerging new data on combination therapy as well as novel agents have shown encouraging results. This report provides the Belgian Hematology Society guidelines according to recent clinical studies. [less ▲]

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See detailAnalytical model for composite joints under sagging moment
Bennacer, M.A.; Berouai, A; Kriker, A et al

in Engineering Structures (2015), 101

Nowadays, modern codes and standards such as the (Eurocode 4, 2004) deal with the characterisation of steel–concrete composite joints in building structures, mainly under hogging bending moments in the ... [more ▼]

Nowadays, modern codes and standards such as the (Eurocode 4, 2004) deal with the characterisation of steel–concrete composite joints in building structures, mainly under hogging bending moments in the beam. However, in sway composite frames or when the composite structure is subjected to an accidental/exceptional event such as earthquake or column loss, the beam-to-column joint may be subjected to sagging bending moment, a loading situation which is not yet covered by the codes. This paper deals with the behaviour of composite beam-to-column external joints under sagging bending moments, mainly focusing on the specific joint component “concrete slab in compression”. Indeed, if reference is made to Eurocodes, the method recommended to characterise structural joints is the component method and the “concrete slab in compression” component has been identified as the missing component to be able to apply this method to composite joints subjected to sagging bending moment. In this article, the finite element method is used to model the slab using VecTor 2 software. Through the performed numerical simulations, the behaviour of the slab is studied in detail and an analytical model is proposed. With the proposed model, it is possible to characterise the concrete slab in compression component and so, to apply the component method to predict the mechanical properties of composite joints subjected to sagging bending moment. [less ▲]

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See detailLa forma diagrammatica tra matematica e arti
Dondero, Maria Giulia ULg

in Rivista Italiana di Filosofia del Linguaggio (2015), numéro spécial

This paper aims to compare the theory of diagram presented in Peirce’s philosophy of mathematics and the reflections on the work of art formulated by Henry Van Lier and René Thom. The Peircean Theory of ... [more ▼]

This paper aims to compare the theory of diagram presented in Peirce’s philosophy of mathematics and the reflections on the work of art formulated by Henry Van Lier and René Thom. The Peircean Theory of diagram states that a diagram is a configuration characterized as a totality (form) that is necessary and at the same time dynamic and experimental. In his lectures about the relation between the local and the global in art (Apologie du logos, 1990), Thom traces a theory of forms that can be compared to the conception of diagram in Peirce’s semiotics. For Thom, beauty is the result of strategies of framing and of composing parts in a dynamic totality. Van Lier’s develops the idea of a perfect totality characterized by a syntax of traits that are at the right place and that couldn’t be organized in any other way, without which the work of art would have no efficacy. For my part, I explore these conceptions of a necessary totality in the arts (aesthetic necessity) and in mathematical diagrams (the demonstration through perceptual forms) in order to describe the differences and the similarities between the theories and the domains of application. [less ▲]

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See detailWIND-STORM: A Decision Support System for the Strategic Management of Windthrow Crises by the Forest Community
Riguelle, Simon ULg; Hebert, Jacques ULg; Jourez, Benoît ULg

in Forests (2015), 6

Storms are one of the most damaging agents for European forests and can cause huge and long-term economic impacts on the forest sector. Recent events and research have contributed to a better ... [more ▼]

Storms are one of the most damaging agents for European forests and can cause huge and long-term economic impacts on the forest sector. Recent events and research have contributed to a better understanding and management of destructive storms, but public authorities still lack appropriate decision-support tools for evaluating their strategic decisions in the aftermath of a storm. This paper presents a decision support system (DSS) that compares changes in the dynamics of the regional forest-based sector after storm events under various crisis management options. First, the development and implementation of a regional forest model is addressed; then, the potential application of the model-based DSS WIND-STORM is illustrated. The results of simulated scenarios reveal that this DSS type is useful for designing a cost-effective regional strategy for storm-damage management in the context of scarce public resources and that public strategies must encompass the whole forest-based sector to be efficient. Additional benefits of such a DSS is to bring together decision-makers and forest stakeholders for a common objective and therefore to enhance participatory approaches to crisis management. [less ▲]

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See detailEuler–Lagrange approach to model heterogeneities in stirred tank bioreactors – Comparison to experimental flow characterization and particle tracking
Delafosse, Angélique ULg; Calvo, Sébastien ULg; Collignon, Marie-Laure ULg et al

in Chemical Engineering Science (2015), 134

The aim of this work is the validation of an Euler–Lagrange modeling approach coupling a CFD-based compartment model (Eulerian approach) and a stochastic model based on a Continuous-Time Markov Chain ... [more ▼]

The aim of this work is the validation of an Euler–Lagrange modeling approach coupling a CFD-based compartment model (Eulerian approach) and a stochastic model based on a Continuous-Time Markov Chain (Lagrangian approach). The turbulent flow structure and the mixing process in a bioreactor stirred by an axial Mixel TT impeller is characterized by PIV and tracer experiments. Comparison between experimental and numerical data shows that the CFD-based compartment model is able to reproduce accurately the spatial heterogeneities inside the bioreactor. The trajectory of a small tracer particle which perfectly follows the fluid flow is measured by optical trajectography. It is then simulated by a stochastic model which is either based on an homogeneous or on an inhomogeneous Continuous Time Markov Chain (CTMC). Comparison of residence and circulation time distributions in three zones defined inside the bioreactor shows that the inhomogeneous CTMC model predicts with an excellent accuracy the particle trajectories inside the bioreactor. The modeling approach proposed here could be an useful tool to design scale-down bioreactors in order to reproduce at lab-scale the stress levels encountered in large-scale production bioreactors and to characterize and compare different bioreactor configurations. [less ▲]

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See detailMy Friend is a WWI Soldier: A Semiopragmatic Approach to Docufictions on Social Networks
Dondero, Maria Giulia ULg; Bouko, Catherine

in Punctum. International Journal of Semiotics (2015), 1(1), 94-107

At the beginning of the twentieth-first century, notable for the triumph of both fiction and a taste for reality (Veyrat-Masson 2008), interactive documentary-dramas appeared on social networks. These ... [more ▼]

At the beginning of the twentieth-first century, notable for the triumph of both fiction and a taste for reality (Veyrat-Masson 2008), interactive documentary-dramas appeared on social networks. These Internet-based audiovisual productions invite semiotics to reconsider its tools in order to grasp their complex, hybrid nature, above and beyond the binary opposition of reality and fiction. After considering the semiotic systems which characterize social networks and condition enunciation (Van Dijck, 2013), we proceed to examine the Léon Vivien, Louis Castel and Little Suzon documentary-dramas from a semio-pragmatic point of view. We will examine the relationship between reality, fiction and realism on the basis of the semiopragmatic models developed by Hanot (2002) and Jost (2001) in order to analyse these audiovisual productions on four levels: profilmic, plastic, iconic and diegetic. By adapting these models to Internet, we will be able to identify the authenticating and fictional strategies employed in such online productions to make the archive images waver between the status of index and icon. [less ▲]

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See detailHyporeactivity of Alveolar Macrophages and Higher Respiratory Cell Permissivity Characterize DBA/2J Mice Infected by Influenza A Virus Hyporeactivity of Alveolar Macrophages and Higher Respiratory Cell Permissivity Characterize DBA/2J Mice Infected by Influenza A Virus.
Casanova Bustos, Tomas Ronaldo ULg; Van de Paar, Els; Desmecht, Daniel ULg et al

in JOURNAL OF INTERFERON & CYTOKINE RESEARCH (2015), 35(10), 808-820

Influenza A virus remains a major public health problem. Mouse models have been widely used to study influenza infection in mammals. DBA/2J and C57BL/6J represent extremes in terms of susceptibility to ... [more ▼]

Influenza A virus remains a major public health problem. Mouse models have been widely used to study influenza infection in mammals. DBA/2J and C57BL/6J represent extremes in terms of susceptibility to influenza A infection among inbred laboratory mouse strains. Several studies focused specifically on the factors responsible for the susceptibility of DBA/2J or the resistance of C57BL/6J and resulted in impressive lists of candidate genes or factors over- or underexpressed in one of the strains. We adopted a different phenotypical approach to identify the critical steps of the infection process accounting for the differences between DBA/2J and C57BL/6J strains. We concluded that both a dysfunction of alveolar macrophages and an increased permissivity of respiratory cells rendered DBA/2J more susceptible to influenza infection. [less ▲]

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See detailMultifractality of quantum wave functions in the presence of perturbations
Dubertrand, Rémy ULg; Garcia-Mata, Ignacio; Georgeot, Bertrand et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2015), 92

We present a comprehensive study of the destruction of quantum multifractality in the presence of perturbations. We study diverse representative models displaying multifractality, including a ... [more ▼]

We present a comprehensive study of the destruction of quantum multifractality in the presence of perturbations. We study diverse representative models displaying multifractality, including a pseudointegrable system, the Anderson model, and a random matrix model. We apply several types of natural perturbations which can be relevant for experimental implementations. We construct an analytical theory for certain cases and perform extensive large-scale numerical simulations in other cases. The data are analyzed through refined methods including double scaling analysis. Our results confirm the recent conjecture that multifractality breaks down following two scenarios. In the first one, multifractality is preserved unchanged below a certain characteristic length which decreases with perturbation strength. In the second one, multifractality is affected at all scales and disappears uniformly for a strong-enough perturbation. Our refined analysis shows that subtle variants of these scenarios can be present in certain cases. This study could guide experimental implementations in order to observe quantum multifractality in real systems. [less ▲]

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See detailDouble hydrophilic polyphosphoester containing copolymers as efficient templating agents for calcium carbonate microparticles
Ergül, Zeynep ULg; Debuigne, Antoine ULg; Calvignac, Brice et al

in Journal of Materials Chemistry B (2015), 3(36), 7227-7236

The use of calcium carbonate (CaCO3) microparticles is becoming more and more attractive in many fields especially in biomedical applications in which the fine tuning of the size, morphology and ... [more ▼]

The use of calcium carbonate (CaCO3) microparticles is becoming more and more attractive in many fields especially in biomedical applications in which the fine tuning of the size, morphology and crystalline form of the CaCO3 particles is crucial. Although some structuring compounds, like hyaluronic acid, give satisfying results, the control of the particle structure still has to be improved. To this end, we evaluated the CaCO3 structuring capacity of novel well-defined double hydrophilic block copolymers composed of poly(ethylene oxide) and a polyphosphoester segment with an affinity for calcium like poly(phosphotriester)s bearing pendent carboxylic acids or poly(phosphodiester)s with a negatively charged oxygen atom on each repeating monomer unit. These copolymers were synthesized by a combination of organocatalyzed ring opening polymerization, thiol–yne click chemistry and protection/deprotection methods. The formulation of CaCO3 particles was then performed in the presence of these block copolymers (i) by the classical chemical pathway involving CaCl2 and Na2CO3 and (ii) by a process based on supercritical carbon dioxide (scCO2) technology in which CO32− ions are generated in aqueous media and react with Ca2+ ions. Porous CaCO3 microspheres composed of vaterite nanocrystals were obtained. Moreover, a clear dependence of the particle size on the structure of the templating agent was emphasized. In this work, we show that the use of the supercritical process and the substitution of hyaluronic acid for a carboxylic acid containing copolymer decreases the size of the CaCO3 particles by a factor of 6 (∼1.5 μm) while preventing their aggregation. [less ▲]

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See detailFluorescent reporter libraries as useful tools for optimizing microbial cell factories: a review of the current methods and applications
Delvigne, Frank ULg; Pêcheux, Hélène; Tarayre, Cédric ULg

in Frontiers in Bioengineering and Biotechnology (2015), 3

The use of genetically encoded fluorescent reporters allows speeding up the initial optimization steps of microbial bioprocesses. These reporters can be used for determining the expression level of a ... [more ▼]

The use of genetically encoded fluorescent reporters allows speeding up the initial optimization steps of microbial bioprocesses. These reporters can be used for determining the expression level of a particular promoter, not only the synthesis of a specific protein but also the content of intracellular metabolites. The level of protein/metabolite is thus proportional to a fluorescence signal. By this way, mean expression profiles of protein/ metabolites can be determined non-invasively at a high-throughput rate, allowing the rapid identification of the best producers. Actually, different kinds of reporter systems are available, as well as specific cultivation devices allowing the on-line recording of the fluorescent signal. Cell-to-cell variability is another important phenomenon that can be integrated into the screening procedures for the selection of more efficient microbial cell factories. [less ▲]

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See detailAcetylene (C2H2) and hydrogen cyanide (HCN) from IASI satellite observations: global distributions, validation, and comparison with model
Duflot, V.; Wespes, C.; Clarisse, L. et al

in Atmospheric Chemistry and Physics (2015), 15

We present global distributions of C2H2 and hydrogen cyanide (HCN) total columns derived from the Infrared Atmospheric Sounding Interferometer (IASI) for the years 2008–2010. These distributions are ... [more ▼]

We present global distributions of C2H2 and hydrogen cyanide (HCN) total columns derived from the Infrared Atmospheric Sounding Interferometer (IASI) for the years 2008–2010. These distributions are obtained with a fast method allowing to retrieve C2H2 abundance globally with a 5% precision and HCN abundance in the tropical (subtropical) belt with a 10% (25 %) precision. IASI data are compared for validation purposes with ground-based Fourier transform infrared (FTIR) spectrometer measurements at four selected stations. We show that there is an overall agreement between the ground-based and space measurements with correlation coefficients for daily mean measurements ranging from 0.28 to 0.81, depending on the site. Global C2H2 and subtropical HCN abundances retrieved from IASI spectra show the expected seasonality linked to variations in the anthropogenic emissions and seasonal biomass burning activity, as well as exceptional events, and are in good agreement with previous spaceborne studies. Total columns simulated by the Model for Ozone and Related Chemical Tracers, version 4 (MOZART-4) are compared to the ground-based FTIR measurements at the four selected stations. The model is able to capture the seasonality in the two species in most of the cases, with correlation coefficients for daily mean measurements ranging from 0.50 to 0.86, depending on the site. IASI measurements are also compared to the distributions from MOZART-4. Seasonal cycles observed from satellite data are reasonably well reproduced by the model with correlation coefficients ranging from -0.31 to 0.93 for C2H2 daily means, and from 0.09 to 0.86 for HCN daily means, depending on the considered region. However, the anthropogenic (biomass burning) emissions used in the model seem to be overestimated (underestimated), and a negative global mean bias of 1% (16 %) of the model relative to the satellite observations was found for C2H2 (HCN). [less ▲]

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See detailAccretion Kinematics through the Warped Transition Disk in HD142527 from Resolved CO(6-5) Observations
Casassus, S.; Marino, S.; Pérez et al

in Astrophysical Journal (2015)

The finding of residual gas in the large central cavity of the HD 142527 disk motivates questions regarding the origin of its non-Keplerian kinematics and possible connections with planet formation. We ... [more ▼]

The finding of residual gas in the large central cavity of the HD 142527 disk motivates questions regarding the origin of its non-Keplerian kinematics and possible connections with planet formation. We aim to understand the physical structure that underlies the intra-cavity gaseous flows, guided by new molecular-line data in CO(6–5) with unprecedented angular resolutions. Given the warped structure inferred from the identification of scattered-light shadows cast on the outer disk, the kinematics are consistent, to first order, with axisymmetric accretion onto the inner disk occurring at all azimuths. A steady-state accretion profile, fixed at the stellar accretion rate, explains the depth of the cavity as traced in CO isotopologues. The abrupt warp and evidence for near free-fall radial flows in HD 142527 resemble theoretical models for disk tearing, which could be driven by the reported low-mass companion, whose orbit may be contained in the plane of the inner disk. The companion's high inclination with respect to the massive outer disk could drive Kozai oscillations over long timescales; high-eccentricity periods may perhaps account for the large cavity. While shadowing by the tilted disk could imprint an azimuthal modulation in the molecular-line maps, further observations are required to ascertain the significance of azimuthal structure in the density field inside the cavity of HD 142527. [less ▲]

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See detailInfluence of the macromolecular surfactant features and reactivity on morphology and surface properties of emulsion-templated porous polymers
Mathieu, Kevin ULg; Jérôme, Christine ULg; Debuigne, Antoine ULg

in Macromolecules (2015), 48(18), 6489-6498

This work investigates key parameters of a straightfor- ward macromolecular surfactant-assisted functionalization strategy of porous polymers produced by high internal phase emulsion (HIPE) polymerization ... [more ▼]

This work investigates key parameters of a straightfor- ward macromolecular surfactant-assisted functionalization strategy of porous polymers produced by high internal phase emulsion (HIPE) polymerization. For that purpose, a series of well-defined amphiphilic poly(ethylene oxide)-b-poly(styrene) (PEO-b-PS) copolymers with various compositions and molar masses were synthesized by radical addition−fragmentation chain transfer (RAFT) polymerization and used as macromolecular surfactants for the emulsion-templated polymerization of styrene/divinylbenzene (S/DVB). The morphology of the resulting foams, referred to as polyHIPEs, was found dependent on the PS block length and concentration of the block copolymer surfactant in the emulsion. Moreover, we determined the lowest PS block length required for preserving the anchoring of the copolymer at the surface by physical entanglement within the S/DVB cross-linked matrix leading to a PEO-coated porous material. The functionalization of the porous monoliths with PEO was evidenced by sessile drop shape analyses and water uptake experiments. The chemical anchoring of the PEO-b-PS at the surface of polyHIPEs was also explored by interfacial initiation of the HIPE polymerization from a PEO-b-PS-RAFT macroinitiator leading to porous structures with permanent PEO coatings. In this case, copolymerizing DVB with acrylate instead of styrene improved the interconnectivity of the porous monoliths. [less ▲]

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See detailCurrent status of fasciolosis in Vietnam: an update and perspectives
Bui Thi, Dung ULg; Pham, Ngoc Doanh; Saegerman, Claude ULg et al

in Journal of Helminthology (2015)

Vietnam is recognized as endemic for fasciolosis. However, most of the available publications have not been published in international journals. This review is based on national and international ... [more ▼]

Vietnam is recognized as endemic for fasciolosis. However, most of the available publications have not been published in international journals. This review is based on national and international Vietnamese publications and highlights the current status of fasciolosis in Vietnam. It also provides some information available in neighboring countries. Updated data on responsible species, distribution, transmission and control aspects, are summarized. The Central region of Vietnam is reported as being highly endemic for fasciolosis with a high number of human patients (more than 20.000 in 2011). Fasciola gigantica is reported as the main species in Vietnam. However, hybrids between F. gigantica and F. hepatica were identified. Both human and animals are infected by the ingestion of raw vegetables and possibly contaminated drinking water. Three lymnaeid snail species (Austropeplea viridis, Radix auricularia, Radix rubiginosa) may act as intermediate host of Fasciola spp. However due to the likely misidentification of snail species and cercariae during the previous decade the critical analysis of published data is difficult. A better understanding of transmission aspects of fasciolosis would allow the implementation of preventive measures of this important neglected zoonotic disease. [less ▲]

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See detailMultimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model
NCHIMI LONGANG, Alain ULg; Courtois, Audrey ULg; EL HACHEMI, Mounia ULg et al

in European Radiology (2015), online

Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction ... [more ▼]

Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results All of the following significantly increased with time post-induction (p < 0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. [less ▲]

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