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See detailDevelopment and validation of a morphologic obstructive sleep apnea prediction score: The DES-OSA score
Deflandre, E.; Degey, S.; Brichant, Jean-Francois ULg et al

in Anesthesia and Analgesia (2016), 122(2), 363-372

BACKGROUND: Obstructive sleep apnea (OSA) is a common and underdiagnosed entity that favors perioperative morbidity. Several anatomical characteristics predispose to OSA. We developed a new clinical score ... [more ▼]

BACKGROUND: Obstructive sleep apnea (OSA) is a common and underdiagnosed entity that favors perioperative morbidity. Several anatomical characteristics predispose to OSA. We developed a new clinical score that would detect OSA based on the patient's morphologic characteristics only. METHODS: Patients (n = 149) scheduled for an overnight polysomnography were included. Their morphologic metrics were compared, and combinations of them were tested for their ability to predict at least mild, moderate-to-severe, or severe OSA, as defined by an apnea-hypopnea index (AHI) >5, >15, or >30 events/h. This ability was calculated using Cohen κ coefficient and prediction probability. RESULTS: The score with best prediction abilities (DES-OSA score) considered 5 variables: Mallampati score, distance between the thyroid and the chin, body mass index, neck circumference, and sex. Those variables were weighted by 1, 2, or 3 points. DES-OSA score >5, 6, and 7 were associated with increased probability of an AHI >5, >15, or >30 events/h, respectively, and those thresholds had the best Cohen κ coefficient, sensitivities, and specificities. Receiver operating characteristic curve analysis revealed that the area under the curve was 0.832 (95% confidence interval [CI], 0.762-0.902), 0.805 (95% CI, 0.734-0.876), and 0.834 (95% CI, 0.757-0.911) for DES-OSA at predicting an AHI >5, >15, and >30 events/h, respectively. With the aforementioned thresholds, corresponding sensitivities (95% CI) were 82.7% (74.5-88.7), 77.1% (66.9-84.9), and 75% (61.0-85.1), and specificities (95% CI) were 72.4% (54.0-85.4), 73.2% (60.3-83.1), and 76.9% (67.2-84.4). Validation of DES-OSA performance in an independent sample yielded highly similar results. CONCLUSIONS: DES-OSA is a simple score for detecting OSA patients. Its originality relies on its morphologic nature. Derived from a European population, it may prove useful in a preoperative setting, but it has still to be compared with other screening tools in a general surgical population and in other ethnic groups. © 2016 International Anesthesia Research Society. [less ▲]

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See detailOsdR of Streptomyces coelicolor and the Dormancy Regulator DevR of Mycobacterium tuberculosis Control Overlapping Regulons
Urem, Mia; van Rossum, Teunke; Bucca, Giselda et al

in mSystems (2016)

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See detailSevere Prolonged Cough as Presenting Manifestation of FIP1L1-PDGFRA+ Chronic Eosinophilic Leukaemia: A Widely Ignored Association.
Roufosse, Florence; Heimann, Pierre; LAMBERT, Frédéric ULg et al

in Respiration; international review of thoracic diseases (2016)

Chronic eosinophilic leukaemia associated with the FIP1L1-PDGFRA fusion gene (F/P+ CEL) is a rare cause of marked persistent hypereosinophilia, arising almost exclusively in male patients. Clinical ... [more ▼]

Chronic eosinophilic leukaemia associated with the FIP1L1-PDGFRA fusion gene (F/P+ CEL) is a rare cause of marked persistent hypereosinophilia, arising almost exclusively in male patients. Clinical presentations are heterogeneous with a higher incidence of eosinophil-mediated cardiomyopathy than in other hypereosinophilic syndrome variants. Features of chronic myeloproliferative disease are often present, including splenomegaly and elevated serum vitamin B12 levels. The diagnosis is made by fluorescence in situ hybridization (FISH) showing the deletion of the CHIC2 locus and/or RT-PCR showing the FIP1L1-PDGFRA fusion transcript. Treatment with imatinib mesylate, a tyrosine kinase inhibitor, results in rapid and complete resolution of hypereosinophilia and associated symptoms, except for those related to sub-endocardial fibrosis that may be irreversible. We report the case of a male patient in whom isolated intractable cough remained the only clinical manifestation of F/P+ CEL for 4 years. Furthermore, eosinophil autofluorescence, an as yet unreported artefact in this setting, precluded the detection of the CHIC2 deletion and further delayed diagnosis, underlining that both FISH and RT-PCR should be performed when this disease is suspected. [less ▲]

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See detailReview of Véronique Maisier’s Violence in Caribbean Literature: Stories of Stones and Blood
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2016), 90(3&4),

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See detailPhénoménologie et grammaire
Leclercq, Bruno ULg; Gauvry, Charlotte ULg

in Bulletin d'Analyse Phénoménologique (2016), 12(2),

Dans le prolongement des travaux sur l’analyticité formelle de Bernard Bolzano, la phénoménologie naissante se caractérise par une attention à la structuration du sens selon des principes purement formels ... [more ▼]

Dans le prolongement des travaux sur l’analyticité formelle de Bernard Bolzano, la phénoménologie naissante se caractérise par une attention à la structuration du sens selon des principes purement formels qui conditionnent la possibilité même de la signification. Husserl par excellence, dans la quatrième Recherche Logique, dégage l’idée d’une grammaire pure régissant les conditions du sens possible (par opposition au non-sens) avant même qu'intervienne la question logique de la consistance (par opposition au contresens). Ce niveau grammatical s’articule autour de catégories de la signification (matière nominale, matière adjectivale, ...) et des lois de leur combinaison, catégories et lois qui peuvent être dégagées par des tests de substituabilité « salva significatione ». Cette idée d’une structure purement grammaticale des significations est aussi explorée par d’autres disciples de Brentano comme Anton Marty, lequel prend part au débat sur la possibilité des « propositions sans sujets » dès ses articles de 1884-1896. Or cette approche formelle de la grammaire qui a réglé l’émergence de la phénoménologie ne va pas sans poser de questions. L’enjeu du numéro est d’interroger le type de formalisme qui est en jeu à l’origine de la phénoménologie pour en préciser les sens et en tester la longévité. La question se pose tout d’abord de savoir si l’hypothèse d’une légalité purement grammaticale est pertinente et quels rapports elle entretiendrait avec 1) la légalité spécifiquement linguistique liée à l'expression de ces significations dans telle ou telle langue ou même dans le langage en général. Les catégories de signification et les lois de leur combinaison précèdent-elles tout langage ? 2) la légalité ontologique qui est celle des objets pensés à travers ces significations. Les objets imposent-ils leur structure aux significations à travers lesquelles on les pense ou, au contraire, les significations imposent-elles leur structure aux objets pensés à travers elles ? 3) la légalité phénoménale qui régit plus particulièrement l'expérience sensible (synthèses passives, etc.). 4) Par ailleurs, on peut se demander si cette légalité grammaticale dégagée par Husserl est purement syntaxique (c’est-à-dire qu’elle se définirait essentiellement par opposition aux combinaisons de signification insensées parce que syntaxiquement mal formées comme « vert est ou ») ou si elle est également sémantique (c’est-à-dire qu’elle se définirait également par opposition aux combinaisons de signification insensées parce qu’absurdes comme « le nombre 2 est vert »). [less ▲]

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See detailA Text Structure Indicator and two Topological Methods: New Ways for Studying Latin Historic Narratives
Longrée, Dominique ULg; Mellet, Sylvie

in DSH: Digital Scholarship in the Humanities (2016)

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See detailCentral nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice.
Jurczyszyn, Artur; Grzasko, Norbert; Gozzetti, Alessandro et al

in American journal of hematology (2016), 91(6), 575-80

The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of ... [more ▼]

The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate and multivariate analyses were performed to identify prognostic factors for survival. The median time from MM diagnosis to CNS MM diagnosis was 3 years. Thirty-eight patients (22%) were diagnosed with CNS involvement at the time of initial MM diagnosis and 134 (78%) at relapse/progression. Upon diagnosis of CNS MM, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated and treated patients had median OS of 2 and 8 months, respectively (P < 0.001). At least one previous line of therapy for MM before the diagnosis of CNS disease and >1 cytogenetic abnormality detected by FISH were independently associated with worse OS. The median OS for patients with 0, 1 and 2 of these risk factors were 25 months, 5.5 months and 2 months, respectively (P < 0.001). Neurological manifestations, not considered chemotherapy-related, observed at any time after initial diagnosis of MM should raise a suspicion of CNS involvement. Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy. Am. J. Hematol. 91:575-580, 2016. (c) 2016 Wiley Periodicals, Inc. [less ▲]

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See detailEvaluation of anode (electro)catalytic materials for the direct borohydride fuel cell: methods and benchmarks
Olu, Pierre-Yves ULg; Job, Nathalie ULg; Chatenet, Marian

in Journal of Power Sources (2016), 327

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See detailEnjeux de la représentation et de la participation politique des émigrés dans leur pays d’origine : Vers une citoyenneté politique externe ?
Lafleur, Jean-Michel ULg

in Social Science Information Studies (2016)

Following years of disinterest or hostility, many sending states are now trying to create or strengthen linkages with citizens residing abroad. To this end, states are adopting new policies and creating ... [more ▼]

Following years of disinterest or hostility, many sending states are now trying to create or strengthen linkages with citizens residing abroad. To this end, states are adopting new policies and creating new institutions dedicated to emigrants. In the past three decades, a majority of states worldwide has adopted external voting legislation that enables citizens abroad to vote (and in certain cases be represented) in the home country without having to return. In this article, I question the emergence of such policies and discuss their impact on immigrant political participation in their country of residence. [less ▲]

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See detailThe network model of depression as a basis for new therapeutic strategies for treating major depressive disorder in Parkinson’s disease
D'Ostilio, Kevin ULg; Garraux, Gaëtan ULg

in Frontiers in Human Neuroscience (2016), 10(161),

The high prevalence of major depressive disorder in people with Parkinson's disease, its negative impact on health-related quality of life and the low response rate to conventional pharmacological ... [more ▼]

The high prevalence of major depressive disorder in people with Parkinson's disease, its negative impact on health-related quality of life and the low response rate to conventional pharmacological therapies call to seek innovative treatments. Here, we review the new approaches for treating major depressive disorder in patients with Parkinson's disease within the framework of the network model of depression. According to this model, major depressive disorder reflects maladaptive neuronal plasticity. Non-invasive brain stimulation using high frequency repetitive transcranial magnetic stimulation over the prefrontal cortex has been proposed as a feasible and effective strategy with minimal risk. The neurobiological basis of its therapeutic effect may involve neuroplastic modifications in limbic and cognitive networks. However, the way this networks reorganize might be strongly influenced by the environment. To address this issue, we propose a combined strategy that includes non-invasive brain stimulation together with cognitive and behavioral interventions. [less ▲]

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See detailDifferential Acute Impacts of Sleeve Gastrectomy, Roux-en-Y Gastric Bypass Surgery and Matched Caloric Restriction Diet on Insulin Secretion, Insulin Effectiveness and Non-Esterified Fatty Acid Levels Among Patients with Type 2 Diabetes.
Thomas, Felicity Louise ULg; Smith, Greg C.; Lu, Jun et al

in Obesity surgery (2016)

BACKGROUND: Bariatric surgery is an increasingly common option for control of type 2 diabetes (T2D) and obesity. Mechanisms underlying rapid improvement of T2D after different types of bariatric surgery ... [more ▼]

BACKGROUND: Bariatric surgery is an increasingly common option for control of type 2 diabetes (T2D) and obesity. Mechanisms underlying rapid improvement of T2D after different types of bariatric surgery are not clear. Caloric deprivation and altered levels of non-esterified fatty acid (NEFA) have been proposed. This study examines how sleeve gastrectomy (SG), Roux-en-Y gastric bypass (GBP) or matched hypocaloric diet (DT) achieves improvements in T2D by characterising components of the glucose metabolism and NEFA levels before and 3 days after each intervention. METHODS: Plasma samples at five time points during oral glucose tolerance test (OGTT) from subjects with T2D undergoing GBP (N = 11) or SG (N = 12) were analysed for C-peptide, insulin and glucose before surgery and 3-day post-intervention or after DT (N = 5). Fasting palmitic, linoleic, oleic and stearic acid were measured. C-peptide measurements were used to model insulin secretion rate (ISR) using deconvolution. RESULTS: Subjects who underwent GBP surgery experienced the greatest improvement in glycaemia (median reduction in blood glucose (BG) from basal by 29 % [IQR -57, -18]) and the greatest reduction in all NEFA measured. SG achieved improvement in glycaemia with lower ISR and reduction in all but palmitoleic acid. DT subjects achieved improvement in glycaemia with an increase in ISR, 105 % [IQR, 20, 220] and stearic acid. CONCLUSIONS: GBP, SG and DT each improve glucose metabolism through different effects on pancreatic beta cell function, insulin sensitivity and free fatty acids. [less ▲]

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See detailGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa et al

in Autophagy (2016), 12(1), 1-222

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See detailPleiotropic Control by Testosterone of a Learned Vocal Behavior and Its Underlying Neuroplasticity(1,2,3).
Alward, Beau A.; Madison, Farrah N.; Parker, Shannon E. et al

in eNeuro (2016), 3(1),

Steroid hormones coordinate multiple aspects of behavior and physiology. The same hormone often regulates different aspects of a single behavior and its underlying neuroplasticity. This pleiotropic ... [more ▼]

Steroid hormones coordinate multiple aspects of behavior and physiology. The same hormone often regulates different aspects of a single behavior and its underlying neuroplasticity. This pleiotropic regulation of behavior and physiology is not well understood. Here, we investigated the orchestration by testosterone (T) of birdsong and its neural substrate, the song control system. Male canaries were castrated and received stereotaxic implants filled with T in select brain areas. Implanting T solely in the medial preoptic nucleus (POM) increased the motivation to sing, but did not enhance aspects of song quality such as acoustic structure and stereotypy. In birds implanted with T solely in HVC (proper name), a key sensorimotor region of the song control system, little or no song was observed, similar to castrates that received no T implants of any sort. However, implanting T in HVC and POM simultaneously rescued all measures of song quality. Song amplitude, though, was still lower than what was observed in birds receiving peripheral T treatment. T in POM enhanced HVC volume bilaterally, likely due to activity-dependent changes resulting from an enhanced song rate. T directly in HVC, without increasing song rate, enhanced HVC volume on the ipsilateral side only. T in HVC enhanced the incorporation and recruitment of new neurons into this nucleus, while singing activity can independently influence the incorporation of new neurons into HVC. These results have broad implications for how steroid hormones integrate across different brain regions to coordinate complex social behaviors. [less ▲]

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See detailTranscriptome of the freshwater amphipod Gammarus pulex hepatopancreas
Gismondi, Eric ULg; Thomé, Jean-Pierre ULg

in Genomics Data (2016), 8

So far, ecotoxicological studies used biomarkers of exposure or of effects in order to investigate the impacts of contaminated areas on biota (Peakall, 1994 [6]). However, although these results are ... [more ▼]

So far, ecotoxicological studies used biomarkers of exposure or of effects in order to investigate the impacts of contaminated areas on biota (Peakall, 1994 [6]). However, although these results are important in the ecotoxicological risk assessment, biomarkers are very specific and only provide information on the biological processes or physiological pathways targeted by the biomarkers experimenters choose to test (Monsinjon and Knigge, 2007 [5]). In recent years, proteomics have become a major tool in ecotoxicology, as they provide a global insight into the mechanism of action of pollutants without the need of hypothesis testing or any preconception on the biological processes likely impacted (Gismondi et al., 2015; Trapp et al., 2015 [7]; Truebano, 2016 [8]). However, the analysis of proteomic results is often limited due to the lack of database, especially for non-model organisms, such as Gammarus sp, commonly used as biological model in ecotoxicology (Sornom et al., 2012 [11]; Vellinger et al., 2013 [9]; Gismondi and Thomé, 2014 [1]; Lebrun et al., 2014 [3]). Here, we performed Illumina HiSeq sequencing to total RNA isolated from the hepatopancreas (i.e. detoxification tissue) of Gammarus pulex males and females coming from uncontaminated river and contaminated river (e.g. PCB, benzo(a)pyrene). Approximately 290Mpaired-end readswere assembled, filtered and sorted into 39,801 contigswhose 10.878 were similar of proteins available in databases. The assembled contigs could represent a reference hepatopancreas transcriptome for G. pulex, and constitute an important resource for future investigations on the impacts of pollutants on invertebrate biota, since itwould improve the understanding of the mechanisms of action involved in toxicity. In addition, the hepatopancreas transcriptome will also allow the identification of new potential biomarkers for the ecotoxicological risk assessments. Assembled contigswere deposited in the European Nucleotide Archive under the BioProject number PRJEB13055, with accession numbers FJVI01000001-FJVI01039801. [less ▲]

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See detailScreening for GPR101 defects in pediatric pituitary corticotropinomas.
Trivellin, Giampaolo; Correa, Ricardo R.; Batsis, Maria et al

in Endocrine-related cancer (2016), 23(5), 357-365

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been ... [more ▼]

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage of cases are still unknown. We investigated the orphan G protein-coupled receptor GPR101, a gene known to be involved in somatotropinomas, for its possible involvement in corticotropinomas. We performed GPR101 sequencing, expression analyses by RT-qPCR and immunostaining, and functional studies (cell proliferation, pituitary hormones secretion, and cAMP measurement) in a series of patients with sporadic CD secondary to ACTH-secreting adenomas in whom we had peripheral and tumor DNA (N=36). No increased GPR101 expression was observed in tumors compared to normal pituitary (NP) tissues, nor did we find a correlation between GPR101 and ACTH expression levels. Sequence analysis revealed a very rare germline heterozygous GPR101 variant (p.G31S) in one patient with CD. Overexpression of the p.G31S variant did not lead to increased growth and proliferation, although modest effects on cAMP signaling were seen. GPR101 is not overexpressed in ACTH-secreting tumors compared to NPs. A rare germline GPR101 variant was found in one patient with CD but in vitro studies did not support a consistent pathogenic effect. GPR101 is unlikely to be involved in the pathogenesis of CD. [less ▲]

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See detailLaissez-nous entrer dans la maison des morts » [A propos du négationnisme du génocide des Tutsis au Rwanda]
Fierens, Jacques ULg; Fierens, Marie

in Témoigner. Entre histoire et mémoire. Revue internationale de la Fondation Auschwitz (2016), 122(avril 20016), 99-111

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See detailFrontières, souverainisme et vacuité
Gemenne, François ULg

in La Revue Nouvelle (2016), 4

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See detailPas d'obstacle constitutionnel pour les sanctions administratives communales
Michiels, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), (2016/1), 79-99

Le législateur, lors de l’instauration du système des sanctions administratives communales, a entendu combattre les incivilités. Cette notiond’«incivilité» vise des comportements dans l’espace public qui ... [more ▼]

Le législateur, lors de l’instauration du système des sanctions administratives communales, a entendu combattre les incivilités. Cette notiond’«incivilité» vise des comportements dans l’espace public qui s’écartent de ce qui est convenable dans la vie en société. En veillant à définir les «incivilités» comme les formes les plus légères de trouble de l’ordre public, de la sécurité, de la santé et de la propreté, qui sont dégradants ou incommodants et qui dépassent les contraintes normales de la vie sociale, le législateur a satisfait aux exigences du principe de légalité.Le droit à une bonne administration de la justice tel qu’il est garanti par l’article 6 de la Convention européenne des droits de l’homme, n’exclut pas qu’une sanction administrative soit infligée par un fonctionnaire, à condition qu’un juge indépendant et impartial puisse exercer un contrôle de pleine juridic-tion sur cette décision administrative. [less ▲]

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See detailEffect of Traveler’s Nationality on Daily Travel Time Expenditure Using Zero-Inflated Negative Binomial Regression Models: Results from Belgian National Household Travel Survey
Eftekhar, Hamed ULg; Creemers, Lieve; Cools, Mario ULg

in Transportation Research Record: Journal of the Transportation Research Board (2016), 2565

In this study, data stemming from the 2010 Belgian National Household Travel Survey were used to assess the effect of a traveler’s nationality on daily travel time expenditure. Negative binomial (zero ... [more ▼]

In this study, data stemming from the 2010 Belgian National Household Travel Survey were used to assess the effect of a traveler’s nationality on daily travel time expenditure. Negative binomial (zero-inflated) models were estimated to isolate the effect of nationality after other contributing factors such as sociodemographics, residential characteristics, transport options, and temporal characteristics were controlled for. The results indicate that even if one controls for a series of other influencing factors, nationality plays a significant role in differences in travel time expenditure. This finding is especially relevant in the development of policy packages that are targeted at social inequalities. From a methodological perspective, methodological options—two weighting schemes and two bootstrap solutions—were presented to provide sufficient support for the conclusions. To generalize the results in further studies, an oversampling of travelers of different nationalities is strongly recommended. Future research should focus more on the underlying psychological constructs of why ethnic and cultural differences persist even if one accounts for other determinants. [less ▲]

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See detailP.Bour. 1 (P.Sorb. inv. 826 = MP³ 2643) : reconstruction codicologique
Carlig, Nathan ULg

in Zeitschrift für Papyrologie und Epigraphik (2016), 198

Based on the autopsy of the 11 folios of P.Bour. 1, the article identifies the original form of this school book, that is a series of 4 biniones, of which only the 1st and the 3rd are entirely kept. The ... [more ▼]

Based on the autopsy of the 11 folios of P.Bour. 1, the article identifies the original form of this school book, that is a series of 4 biniones, of which only the 1st and the 3rd are entirely kept. The survey was pursued with the study of rests of binding and of the state os preservation of each folio. [less ▲]

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See detailA pilot double-blind, randomized, placebo-controlled trial of the efficacy of trace elements in the treatment of endometriosis-related pain: study design and methodology
OBERWEIS, Didier; MANDELENAT, Patrick; Nisolle, Michelle ULg

in Nutrition and Dietary Supplements (2016), 8

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various ... [more ▼]

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various distressing symptoms, particularly pelvic pain, which adversely affect patients’ quality of life. It is an estrogen-dependent disease. There is evidence both in animals and in humans that metal ions can activate the estrogen receptors. They are defined as a variety of xenoestrogens, called metalloestrogens, which could act as endocrine disruptors. Therefore, it could be considered to act on this gynecological disorder using food supplements containing trace elements (ie, nutripuncture). The assumption is that they could modulate estrogen receptors and thus influence the tropism and the survival of cells involved in endometriosis. By a modulation of the antioxidant system, they might also interact with various parameters influencing tissue biochemistry. The objective of this article is to describe and discuss the design and methodology of an ongoing double-blind, randomized, placebo-controlled study aiming to evaluate the efficacy of metal trace elements on the reduction of pain and improvement of quality of life, in patients with a revised American Fertility Society Score Stages II–IV endometriosis, combined or not with adenomyosis, during a treatment period of 4 months. Trace elements or placebo is proposed in the absence of any other treatment or as an add-on to current therapies, such as sexual hormones, nonsteroidal anti-inflammatory drugs, and surgery. A placebo run-in period of one menstrual cycle or 30 days for women in amenorrhea has been scheduled to eliminate the patients who are responding too much to the placebo. After a 1:1 ratio randomization on Day 0, the treatment with trace elements or placebo will last for 4 monts (120 days). [less ▲]

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See detailPositive Operations on Wastewater Sludge Drying: Comparison of Back-Mixing and Sawdust Addition
Li, Jie; Plougonven, Erwan ULg; Fraikin, Laurent ULg et al

in Energy & Fuels (2016), 30(4), 3014-3019

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See detailReal-time Recordings of Migrating Cortical Neurons from GFP and Cre Recombinase Expressing Mice.
Tielens, Sylvia ULg; Godin, Juliette D.; Nguyen, Laurent ULg

in Current protocols in neuroscience (2016), 74

The cerebral cortex is one of the most intricate regions of the brain that requires elaborate cell migration patterns for its development. Experimental observations show that projection neurons migrate ... [more ▼]

The cerebral cortex is one of the most intricate regions of the brain that requires elaborate cell migration patterns for its development. Experimental observations show that projection neurons migrate radially within the cortical wall, whereas interneurons migrate along multiple tangential paths to reach the developing cortex. Tight regulation of the cell migration processes ensures proper positioning and functional integration of neurons to specific cerebral cortical circuits. Disruption of neuronal migration often leads to cortical dysfunction and/or malformation associated with neurological disorders. Unveiling the molecular control of neuron migration is thus fundamental to understanding the physiological or pathological development of the cerebral cortex. In this unit, protocols allowing detailed analysis of patterns of migration of both interneurons and projection neurons under different experimental conditions (i.e., loss or gain of function) are presented. [less ▲]

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See detailL’adaptation du pervers et du psychopathe : compréhension phénoménologique et éthologique
Englebert, Jérôme ULg

in PSN. Psychiatrie, Sciences Humaines, Neurosciences (2016), 16

Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have ... [more ▼]

Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have to note that there are moments of mismatch and maladjustment. These ‘‘perverse moments’’ are very important to be observed and regarded as a pathognomonic symptomatology. The specificity of the perverse functioning should be viewed as a continuum of adaptation along which an individual may pass from ‘‘hyperadaptation’’ on the one hand, to moments of failures and mis-adapting on the other hand. Then, we propose a comparison between the binswangerian conception of mania and the psychopathic functioning. The maniac has a fundamental crisis of the ‘‘ego’’, which the psychopath does not have. A second finding of our investigations concerns emotions and the dimension of the adaptive psychopathic disorder. The last point we discuss is about the concepts of empathy and sympathy. Finally, a significant part of this paper is to propose a differentiation concerning adaptive behaviour: one is more social (the pervert); the other is more solitary (the psychopath). [less ▲]

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See detailPredictions of Pinning
Paruch, Patrycja; Ghosez, Philippe ULg

in Nature (2016), 534

A multiscale model has been implemented that provides accurate predictions of the behaviour of ferroelectric materials in electric fields, and might aid efforts to design devices such as sensors and ... [more ▼]

A multiscale model has been implemented that provides accurate predictions of the behaviour of ferroelectric materials in electric fields, and might aid efforts to design devices such as sensors and digital memory. [less ▲]

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See detailLong-term analysis of rainfall and temperature data in Burkina Faso (1950–2013)
De Longueville, Florence; Hountondji, Yvon-Carmen; Kindo, Issa et al

in International Journal of Climatology (2016)

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See detailIs the Sørensen test valid to assess muscle fatigue of the trunk extensor muscles?
Demoulin, Christophe ULg; Boyer, Mathieu; Duchateau, Jacques et al

in Journal of Back and Musculoskeletal Rehabilitation (2016), 00

BACKGROUND: Very few studies have quantified the degree of fatigue characterized by the decline in the maximal voluntary contraction (MVC) force of the trunk extensors induced by the widely used Sørensen ... [more ▼]

BACKGROUND: Very few studies have quantified the degree of fatigue characterized by the decline in the maximal voluntary contraction (MVC) force of the trunk extensors induced by the widely used Sørensen test. OBJECTIVE: Measure the degree of fatigue of the trunk extensor muscles induced by the Sørensen test. METHODS: Eighty young healthy subjects were randomly divided into a control group (CG) and an experimental group (EG), each including 50% of the two genders. The EG performed an isometric MVC of the trunk extensors (pre-fatigue test) followed by the Sørensen test, the latter being immediately followed by another MVC (post-fatigue test). The CG performed only the preand post-fatigue tests without any exertion in between. RESULTS: The comparison of the pre- and post-fatigue tests revealed a significant (P <0.05) decrease in MVC force normalized by body mass (−13%) in the EG, whereas a small increase occurred in the CG (+2.7%, P = 0.001). CONCLUSIONS: This study shows that the Sørensen test performed until failure in a young healthy population results in a reduced ability of the trunk extensor muscles to generate maximal force, and indicates that this test is valid for the assessment of fatigue in trunk extensor muscles. [less ▲]

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See detailUse of donor milk in the neonatal intensive care unit
de halleux, Virginie; Pieltain, Catherine; SENTERRE, Thibault ULg et al

in Seminars in Fetal & Neonatal Medicine (2016)

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See detailMode of Delivery: A Modifiable Risk Factor for Subsequent Stress Urinary Incontinence?
Waltregny, David ULg

in European Urology (2016), 70(1), 159-60

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See detailDe la perversion au pervers ; du sexuel à l’adaptatif
Englebert, Jérôme ULg

in Psychosomatique Relationnelle (2016), 6

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See detailContraception hormonale chez l'adolescente avec thrombophilie biologique
Minon, Jean-Marc; Vasbien, Myriam; DRESSE, Marie-Françoise ULg et al

in Belgian Journal of Paediatrics (2016), 18(2), 173-176

Venous thromboembolism among pill users is rare but is a serious complication. Women with inherited thrombophilia are at increased risk when taking combined oral contraceptives. It is also truth for the ... [more ▼]

Venous thromboembolism among pill users is rare but is a serious complication. Women with inherited thrombophilia are at increased risk when taking combined oral contraceptives. It is also truth for the contraceptive patch and vaginal ring. Hence, the adolescents with a know biological thrombophilia should not take htis type of hormonal conraception. However, some of these thrombophilia should not preclude use of estrogen containing contraception. Actually, if thrombophilia testing can be justified in asymptomtic patient at high risk, it is sometimes performed as screening in adolescent before estrogen-containnig contraception use ( non recommended). In these situations and considering the venous thrombosis as a multicausal disease, the choice of contraceptive methods is argued on the base of family history and other personnal risk factors of venous thrombosis. [less ▲]

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See detailGlucosinolate profiles by HPLC-DAD, phenolic compositions and antioxidant activity of Eruca vesicaria longirostris: Impact of plant part and origin
Bouacida, Saoussen; Koubaier, Hayet Ben Haj; Snoussi, Ahmed et al

in Mediterranean Journal of Chemistry (2016), 5(5), 528-539

The glucosinolate profiles, phenol and flavonoid contents and the antioxidant activity of Eruca vesicaria longirostris were studied for different organs and origins. Eleven desulpho-glucosinolates (DS ... [more ▼]

The glucosinolate profiles, phenol and flavonoid contents and the antioxidant activity of Eruca vesicaria longirostris were studied for different organs and origins. Eleven desulpho-glucosinolates (DS-GLSs) were isolated and quantified by lipid chromatography- DAD. Similarity between profiles was obtained. Total DS-GLS content, expressed as sinigrin equivalents (SE) revealed a certain variabilily ranging between (76.07-45.61), (27.01-13.53), (4.52 -18.01), (9.39-3.37) and (1.16-13.99) μmol /g DW for seeds, flowers, leaves, roots and stems, respectively. [less ▲]

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See detailEndocrine activity of mycotoxins and mycotoxin mixtures
Demaegdt; Daminet; Evrard et al

in Food & Chemical Toxicology (2016), 96

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See detailCOMMENT JE TRAITE ... une colique néphrétique.
Lavergne, O.; Bonnet, Quentin; Thomas, Alexandre et al

in Revue Médicale de Liège (2016), 71(5), 220-6

Renal colic (RC) represents nearly 2% of emergency department admissions. RC is defined by the occurrence of back pain which may radiate towards the abdomen and external genitals. In adults, the ... [more ▼]

Renal colic (RC) represents nearly 2% of emergency department admissions. RC is defined by the occurrence of back pain which may radiate towards the abdomen and external genitals. In adults, the obstruction is caused by a urinary stone in 80% of cases. The 20 % of non-stone related RCs are due either to an intrinsic obstruction (pyeloureteral junction stenosis, ureteral tumor, ...) or an extrinsic compression (pelvic tumor, lymphadenopathy ...). In over 90% of cases, an RC does not require hospitalization and is treated with medication. In contrast, complicated renal colic (CRC) requires hospitalization with specialized care. Obstructive pyelonephritis (OPN) is a form of CRC and the diagnosis should be considered in a clinical presentation of "renal colic" with acute pyelonephritis. This is a true emergency requiring surgical drainage of the upper urinary tract upstream of the obstacle, as well as antibiotic therapy. It must be kept in mind that some clinical presentations may be atypical, especially in the elderly, which can delay the diagnosis and, thus, the management. The gold standard for diagnosis is CT urography. [less ▲]

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See detailSafety in Long Term Radioactive Waste Management: Insight and Oversight
Schröder, Jantine; Rossignol, Nicolas ULg; Van Oudheusden, Michiel ULg

in Safety Science (2016), 85

High-level, long-lived radioactive waste remains hazardous for periods that go well beyond our human conception of time (many thousands of years). Because active safety measures are considered unreliable ... [more ▼]

High-level, long-lived radioactive waste remains hazardous for periods that go well beyond our human conception of time (many thousands of years). Because active safety measures are considered unreliable, unjustifiable and simply impossible over such long time spans, experts worldwide recommend geological disposal as the preferred strategy for long-term radioactive waste management, to a large extent due to its promise of delivering ‘passive safety’. Passive safety refers to the repository being safe ‘by itself’, i.e. unmediated by human actors and actions. Safety is thus approached technically and delineated as an intrinsic property of the disposal system. As such, the notion of 'passive safety' entails a system simplification that allows for approaching safety in a more calculable and predictable manner than would be the case for 'active safety'. In this article, we describe and analyze the ambiguity of this seemingly straightforward approach to safety. Drawing on constructivist insights from safety science and science and technology studies, we propose a more integrated sociotechnical vision that transcends the active versus passive safety division. The notion of 'oversight', as it is currently starting to surface in international radioactive waste management discourses, will be used as a sensitizing concept, offering potential to elaborate such an integrated vision. [less ▲]

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See detailLa couverture santé universelle dans les pays à revenus faibles et intermédiaires : analyses économiques
Paul, Elisabeth ULg; Bodson, Oriane ULg; Ridde, Valéry et al

in Reflets et Perspectives de la Vie Economique (2016), 1

Les pays à revenu faible et intermédiaire sont confrontés à des besoins de financement élevés pour assurer une couverture santé universelle (CSU) permettant à chacun d'avoir accès à des services de santé ... [more ▼]

Les pays à revenu faible et intermédiaire sont confrontés à des besoins de financement élevés pour assurer une couverture santé universelle (CSU) permettant à chacun d'avoir accès à des services de santé de qualité sans encourir de difficultés financières. Cet article tente de montrer comment l'analyse économique peut être mobilisée pour identifier des stratégies utiles pour tendre vers la CSU. Trois axes complémentaires où l'analyse économique a une plus-value sont présentés : i) la mobilisation des ressources et l'équité verticale ; ii) l'amélioration de l'efficacité dans l'allocation des ressources et l'équité horizontale ; iii) la gestion opérationnelle des ressources, en particulier à travers le financement basé sur les résultats (efficience). Pour chacun, nous présentons un bref état des lieux de l'état des connaissances et évoquons quelques perspectives de recherche. [less ▲]

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See detailOrbitally induced hierarchy of exchange interactions in zigzag antiferromagnetic state of honeycomb silver delafossite Ag3Co2SbO6
Zvereva, E.A.; Stratan, M.I.; Ushakov, A.V. et al

in Dalton Transactions (2016)

We report the revised crystal structure, static and dynamic magnetic properties of quasi-two dimensional honeycomb lattice silver delafossite Ag3Co2SbO6. The magnetic susceptibility and specific heat data ... [more ▼]

We report the revised crystal structure, static and dynamic magnetic properties of quasi-two dimensional honeycomb lattice silver delafossite Ag3Co2SbO6. The magnetic susceptibility and specific heat data are consistent with the onset of antiferromagnetic long range order at low temperatures with Néel temperature TN ~ 21.2 K. In addition, the magnetization curves revealed a field-induced (spin-flop type) transition below TN in moderate magnetic fields. The GGA+U calculations show the importance of the orbital degrees of freedom, which maintain a hierarchy of exchange interaction in the system. The strongest antiferromagnetic exchange coupling was found in the shortest Co-Co pairs and is due to direct and superexchange interaction between the half-filled xz+yz orbitals pointing directly to each other. The other four out of six nearest neighbor exchanges within the cobalt hexagon are suppressed, since for these bonds active half-filled orbitals turned out to be parallel and do not overlap. The electron spin resonance (ESR) spectra reveal a broad absorption line attributed to Co2+ ion in octahedral coordination with average effective g-factor g=2.40±0.05 at room temperature and show strong divergence of ESR parameters below ~ 150 K, which implies an extended region of short-range correlations. Based on the results of magnetic and thermodynamic studies in applied fields, we propose the magnetic phase diagram for the new honeycomb-lattice delafossite. [less ▲]

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See detailClassification of riparian forest species and health condition using multi-temporal and hyperspatial imagery from unmanned aerial system
Michez, Adrien ULg; Piégay, Hervé; Lisein, Jonathan ULg et al

in Environmental Monitoring and Assessment (2016), 188(3),

Riparian forests are critically endangered many anthropogenic pressures and natural hazards. The importance of riparian zones has been acknowledged by European Directives, involving multi-scale monitoring ... [more ▼]

Riparian forests are critically endangered many anthropogenic pressures and natural hazards. The importance of riparian zones has been acknowledged by European Directives, involving multi-scale monitoring. The use of this very high resolution and hyperspatial imagery in a multi-temporal approach is an emerging topic. The trend is reinforced by the recent and rapid growth of the use of the unmanned aerial system (UAS), which has prompted the development of innovative methodology. Our study proposes a methodological framework to explore how a set of multi-temporal images acquired during a vegetative period can differentiate some of the deciduous riparian forest species and their health conditions. More specifically, the developed approach intends to identify, through a process of variable selection, which variables derived from UAS imagery and which scale of image analysis are the most relevant to our objectives. The methodological framework is applied to two study sites to describe the riparian forest through two fundamental characteristics: the species composition and the health condition. These characteristics were selected not only because of their use as proxies for the riparian zone ecological integrity but also because of their use for river management. The comparison of various scales of image analysis identified the smallest OBIA objects (ca. 1 m²) as the most relevant scale. Variables derived from spectral information (bands ratio's) were identified as the most appropriate, followed by variables related to the vertical structure of the forest. Classification results show good overall accuracies for the species composition of the riparian forest (five classes, 79.5 and 84.1 % for Site 1 and Site 2). The classification scenario regarding the health condition of the black alders of the Site 1 performed the best (90.6 %). The quality of the classification models developed with a UAS-based, cost-effective, and semi-automatic approach competes successfully with those developed using more expensive imagery, such as multispectral and hyperspectral airborne imagery. The high overall accuracy results obtained by the classification of the diseased alders open the door to applications dedicated to monitoring of the health conditions of riparian forest. Our methodological framework will allow UAS users to manage large imagery metrics datasets derived from those dense time series. [less ▲]

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See detailThe Uptake of 18F-FDG by Renal Allograft in Kidney Transplant Recipients Is Not Influenced by Renal Function.
Jadoul, Alexandre; Lovinfosse, Pierre; Weekers, Laurent et al

in Clinical Nuclear Medicine (2016), 41(9), 683-7

PURPOSE OF THE REPORT: F-FDG PET/CT has been recently proposed as a noninvasive tool for the diagnosis of renal allograft acute rejection (AR) in kidney transplant recipients (KTRs). Still, the influence ... [more ▼]

PURPOSE OF THE REPORT: F-FDG PET/CT has been recently proposed as a noninvasive tool for the diagnosis of renal allograft acute rejection (AR) in kidney transplant recipients (KTRs). Still, the influence of kidney function on F-FDG uptake by renal grafts remains unknown. PATIENTS AND METHODS: We retrospectively identified all KTRs who underwent at least one F-FDG PET/CT. Kidney transplant recipients with documented pyelonephritis or AR were excluded. Estimated glomerular filtration rate (eGFR) was assessed using chronic kidney disease (CKD)-EPI equation. Mean standardized uptake values (SUVmean) of renal graft cortex and aorta were measured in 4 and 1 volumes of interest, respectively. Spearman rank correlation coefficient (rho) and analysis of variance (ANOVA) were performed. RESULTS: Eighty-two KTRs underwent F-FDG PET/CT for tumor staging (n = 46), suspected infection (n = 11), or fever of unknown origin (n = 25). Mean eGFR was 50 +/- 19 mL/min per 1.73 m, including CKD stage 1 (n = 3), stage 2 (n = 21), stage 3a (n = 20), stage 3b (n = 29), and stage 4 (n = 9). Mean kidney and aorta SUVmean were 1.8 +/- 0.2 and 1.7 +/- 0.3, respectively. No significant correlation was observed between eGFR and kidney SUVmean (rho, 0.119; P, 0.28) or aorta SUVmean (rho, -0.144; P, 0.20). ANOVA showed no difference of kidney (P, 0.62) and aorta (P, 0.85) SUVmean between CKD groups. Mean coefficient of variation (on the basis of kidney SUVmean of >3 consecutive F-FDG PET/CT in 15 patients with no significant change of eGFR) reached 13.1%. CONCLUSIONS: The uptake of F-FDG by renal allografts within an hour postinjection is not significantly impacted by CKD. [less ▲]

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See detailChemoautotrophy and anoxygenic photosynthesis within the water column of a large meromictic tropical lake (Lake Kivu, East Africa)
Morana, Cédric; Roland, Fleur ULg; Crowe, Sean A. et al

in Limnology and Oceanography (2016)

We quantified chemoautotrophic and anoxygenic photosynthetic microbial production in the water column of Lake Kivu, a permanently stratified tropical lake situated amidst volcanic activity, and aimed to ... [more ▼]

We quantified chemoautotrophic and anoxygenic photosynthetic microbial production in the water column of Lake Kivu, a permanently stratified tropical lake situated amidst volcanic activity, and aimed to identify the microorganisms involved in these processes through the analysis of their phospholipid fatty acid (PLFA) content and stable isotope (13C) labelling of PLFA in a set of incubation experiments. Data demonstrate the existence of a biogeochemically active chemoautotrophic bacterial community in the redoxcline of Lake Kivu (50–70 m). PLFA data indicate that the bacterial communities are structured vertically in the water column, with a large dissimilarity between the oxic and anoxic waters. Maximum volumetric dark CO2 fixation rates measured in Lake Kivu were in the same range as values reported from H2S-rich marine redoxclines, such as the Black and Baltic Seas, and the Cariaco Basin. Similarly, maximal chemoautotrophic activities in Lake Kivu were observed in sulfidic waters, just below the oxycline. Anoxygenic photosynthetic production was never observed in the main basin of Lake Kivu. However, anoxygenic phototrophs largely dominated CO2 fixation in the illuminated redoxcline of Kabuno Bay, a shallower ferruginous sub-basin. Overall, this study supports the idea that chemoautotrophs and/or anoxygenic photoautotrophs might play an important role in the flow of carbon and energy in permanently stratified tropical ecosystems. In Lake Kivu, these processes significantly contribute to organic matter biosynthesis and exert an indirect control on oxygenic photoautotrophs by shortcircuiting the vertical transport of nutrients to the illuminated and oxygenated surface waters. [less ▲]

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See detailWhat mediates postoperative risk in obstructive sleep apnea: airway obstruction, nocturnal hypoxia or both ?
DEFLANDRE, Eric; BONHOMME, Vincent ULg; BRICHANT, Jean-François ULg et al

in Canadian Journal of Anaesthesia = Journal Canadien d'Anesthésie (2016)

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See detailScientific Problems Addressed by the Spektr-UV Space Project (World Space Observatory—Ultraviolet)
Boyarchuk, A.A.; others; Gérard, Jean-Claude ULg et al

in Astronomy Reports (2016), 60(1), 1-42

The article presents a review of scientific problems and methods of ultraviolet astronomy, focusing on perspective scientific problems (directions) whose solution requires UV space observatories. These ... [more ▼]

The article presents a review of scientific problems and methods of ultraviolet astronomy, focusing on perspective scientific problems (directions) whose solution requires UV space observatories. These include reionization and the history of star formation in the Universe, searches for dark baryonic matter, physical and chemical processes in the interstellar medium and protoplanetary disks, the physics of accretion and outflows in astrophysical objects, from Active Galactic Nuclei to close binary stars, stellar activity (for both low-mass and high-mass stars), and processes occurring in the atmospheres of both planets in the solar system and exoplanets. Technological progress in UV astronomy achieved in recent years is also considered. The well advanced, international, Russian-led Spektr-UV (World Space Observatory—Ultraviolet) project is described in more detail. This project is directed at creating a major space observatory operational in the ultraviolet (115–310 nm). This observatory will provide an effective, and possibly the only, powerful means of observing in this spectral range over the next ten years, and will be an powerful tool for resolving many topical scientific problems. [less ▲]

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See detailThe Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Cao, Martine ULg; Royce, Darlene B.; Risingsong, Renee et al

in Cancer prevention research (Philadelphia, Pa.) (2016), 9(1), 105-14

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both ... [more ▼]

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both drugs are useful for prevention of lung cancer in A/J mice. These molecules markedly reduced tumor number, tumor size, and total tumor burden, when chronically administered to A/J mice that had been initiated with the mutagenic carcinogen, vinyl carbamate. Moreover, LG100268 synergized with the histone deacetylase inhibitor, vorinostat, for prevention of experimental lung cancer and enhanced the effect of carboplatin/paclitaxel for treatment of experimental lung cancer. Both rexinoids diminished the percentage of high-grade, highly malignant adenocarcinomas found at autopsy. In cell culture studies, the rexinoids exhibited potent anti-inflammatory properties at nanoMolar concentrations. These drugs suppressed the ability of lipopolysaccharide to stimulate the synthesis and secretion of nitric oxide and inflammatory cytokines and chemokines, such as IL6, IL1beta, CXCL2, and CSF3, in macrophage-like RAW264.7 cells. The present results suggest that LG100268, LG101506, or a related rexinoid may have useful clinical applications in the field of oncology. Cancer Prev Res; 9(1); 105-14. (c)2015 AACR. [less ▲]

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See detailStratigraphy and depositional environments of the Late Famennian (Late Devonian) of Southern Belgium and characterization of the Strud locality
Denayer, Julien ULg; Prestianni, Cyrille; Gueriau, Pierre et al

in Geological Magazine (2016), 153(1), 112-127

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods ... [more ▼]

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods. The Strud locality has yielded a diverse flora and fauna including seed-plants, tetrapods, various placoderm, actinopterygian, acanthodian and sarcopterygian fishes, crustaceans (anostracans, notostracans, conchostracans and decapods) and a putative complete insect. This fossil assemblage is one of the oldest continental – probably fresh-water – ecosystems with a considerable vertebrate and invertebrate diversity. The study of the palaeoenvironment of the Strud locality is crucial because it records one of the earliest and most important phases of tetrapod evolution that took place after their emergence but before their terrestrialization. It raises the question of environmental and ecological conditions for the Devonian aquatic ecosystem and the selection pressures occurring at the onset of tetrapod terrestrialization. The present study characterized the fluvial facies of the Upper Famennian sedimentary rocks of Strud and the surrounding areas. The exceptional preservation of arthropods and plants in the main fossiliferous layers is explained by rapid burial in the fine-grained sediment of the quiet and confined flood plain environment. Newly investigated fossiliferous sections in the Meuse–Samson area led to the description and correlation of key sections (Strud, Wierde and Jausse sections, complemented by the less continuous Haltinne, Huy and Coutisse sections). Moreover, the investigated sections allowed a review of the age of the fossiliferous horizon, which is now definitely considered to be Late Famennian in age. [less ▲]

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See detailLes droits fondamentaux, au coeur de la pluralité des sources et de la pluralité des juges: vers une "dématérialisation" des droits fondamentaux?
Rosoux, Géraldine ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016)

L'article contient un résumé de la thèse de doctorat de l'auteur, publiée chez Bruylant en 2015.

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See detailRotation of melting ice disks due to melt fluid flow
Dorbolo, Stéphane ULg; adami, nicolas; Dubois, Charles ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2016)

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See detailLife cycle assessment of hybrid vehicles recycling: Comparison of three business lines of dismantling
Belboom, Sandra ULg; Lewis, Grégory; Bareel, Pierre-François et al

in Waste Management (2016), 50

This paper undertakes an environmental evaluation of hybrid vehicles recycling, using industrial data from Comet Traitement SA in Belgium. Three business lines have been modelled and analysed. The first ... [more ▼]

This paper undertakes an environmental evaluation of hybrid vehicles recycling, using industrial data from Comet Traitement SA in Belgium. Three business lines have been modelled and analysed. The first one is relative to the business as usual with a dismantling to recover batteries and engines followed by shredding and post shredding treatments. The second one considers, in addition, the removal of electronic control units (ECU) before shredding followed by same steps than in the first line and the last one is relative to the additional removal of big plastic parts before shredding and business as usual post shredding treatments. Results show non-significant environmental benefits when ECU or large parts of plastics are recovered before shredding. Improvements in terms of environmental benefits are lower than the uncertainty of the results. Indeed, the performing usual process for end-of-life vehicles (ELV) treatment reaches 97% of the ELV which is valorised in terms of metal and energy recoveries. Post shredding treatment units include metals, plastics and energy recovery of residues. Comet business as usual route for ELV valorisation is in accordance with the requirements of the European directive and recommendations for further improvement with dismantling of other parts (ECU or plastics) before shredding are non-relevant in this case. [less ▲]

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See detailHigh serum sclerostin levels are associated with a better outcome in haemodialysis patients
Jean, Guillaume; Chazot, Charles; Bresson, Eric et al

in Nephron. Clinical Practice (2016)

Sclerostin is an osteocyte hormone that de- creases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chron- ic kidney disease and ... [more ▼]

Sclerostin is an osteocyte hormone that de- creases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chron- ic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. Aim: To assess the correlation of serum sclerostin levels with VC, bone mineral density (BMD), and survival rate in HD patients. Methods: A cross-sectional study was conducted in prevalent HD patients to correlate serum sclerostin tertiles with the Kauppila aortic calcification score, BMD scores and survival rate. Results: We studied 207 patients who had a mean serum sclerostin level of 1.9 ± 0.7 ng/ml. Compared to patients in the 1st tertile of serum sclerostin levels (0.6–1.53 ng/ml), patients in the 3rd tertile (2.2–4.6 ng/ml) were significantly older (73.7 ± 12 vs. 64.7 ± 18 years), more frequently of the male gender (74 vs. 48%), had lower serum bone-specific alkaline phosphatases values (14 ± 9 vs. 20.4 ± 13 µg/l), were less frequently treated with alfacalcidol, displayed lower aortic calcification scores (9.5 ± 5 vs. 12.5 ± 7/24) and had higher BMD scores. Furthermore, patients of the 3rd tertile displayed a lower mortality rate compared to tertile 1 using multivariable adjusted Cox mod- el (hazard ratio 0.5, 95% CI 0.25–0.93, p = 0.03). The main fac- tors associated with VC score were age, diabetes, cardiovas- cular disease, CRP level and Warfarin use. Conclusion: Our study of HD patients shows that higher serum sclerostin lev- els are associated with higher BMD, lower aortic calcification scores, and a better survival rate. [less ▲]

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See detailThermal properties of Ti-doped Cu–Zn soft ferrites used as thermally actuated material for magnetizing superconductors
Stachowiak, Piotr; Mucha, Jan; Szewczyk, Daria et al

in Journal of Physics : D Applied Physics (2016), 49

A great majority of widely used ferrite ceramics exhibit a relatively high temperature of order–disorder phase transition in their magnetic subsystem. For applications related to the magnetization process ... [more ▼]

A great majority of widely used ferrite ceramics exhibit a relatively high temperature of order–disorder phase transition in their magnetic subsystem. For applications related to the magnetization process of superconductors, however, a low value of Tc is required. Here we report and analyze in detail the thermal properties of bulk Ti-doped Cu–Zn ferrite ceramics Cu0.3Zn0.7Ti0.04Fe1.96O4 and Mg0.15Cu0.15Zn0.7Ti0.04Fe1.96O4. They are characterized by a Curie temperature in the range 120–170 K and a maximum DC magnetic susceptibility exceeding 20 for the Cu0.3Zn0.7Ti0.04Fe1.96O4 material. The temperature dependence of both the specific heat Cp and of the thermal conductivity κ, determined between 2 and 300 K, are found not to exhibit any peculiar feature at the magnetic transition temperature. The low-temperature dependence of both κ and the mean free path of phonons suggests a mesoscopic fractal structure of the grains. From the measured data, the characteristics of thermally actuated waves are estimated. The low magnetic phase transition temperature and suitable thermal parameters make the investigated ferrite ceramics applicable as magnetic wave producers in devices designed for magnetization of high-temperature superconductors. [less ▲]

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See detailreview of Frédéric Duval, Les mots de l'édition de textes
Morato, Nicola ULg

in French Studies (2016), 70(2),

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See detailComment je traite… L’insomnie chronique par la thérapie comportementale et cognitive
Dethier, Marie ULg; Blairy, Sylvie ULg; POIRRIER, Robert ULg

in Revue Médicale de Liège (2016)

L’insomnie est actuellement traitée majoritairement par la pharmacothérapie. Or la thérapie comportementale et cognitive pour l’insomnie présente une meilleure efficacité à long terme que celle-ci. Dans ... [more ▼]

L’insomnie est actuellement traitée majoritairement par la pharmacothérapie. Or la thérapie comportementale et cognitive pour l’insomnie présente une meilleure efficacité à long terme que celle-ci. Dans cet article nous décrivons les principes de base de ce traitement psychothérapeutique de courte durée. Il s’agit de combiner des méthodes de restriction de sommeil, de contrôle des stimuli en lien avec le sommeil, d’apprentissage de techniques de relaxation, des conseils sur l’hygiène de sommeil et des techniques de thérapie cognitive appliquées aux cognitions envahissants les moments d’insomnie. [less ▲]

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See detailProcedural learning, consolidation, and transfer of a new skill in Developmental Coordination Disorder
Lejeune, Caroline ULg; Wansard, Murielle ULg; Geurten, Marie ULg et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016), 22(2),

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill ... [more ▼]

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill automatization (i.e., the stages of fast learning, consolidation, and slow learning). Transfer of the skill to a new situation was also assessed. We tested 34 children aged 6–12 years with and without DCD on a perceptuomotor adaptation task, a form of procedural learning that is thought to involve the cerebellum and the basal ganglia (regions whose impairment has been associated with DCD) but also other brain areas including frontal regions. The results showed similar rates of learning, consolidation, and transfer in DCD and control children. However, the DCD children's performance remained slower than that of controls throughout the procedural task and they reached a lower asymptotic performance level; the difficulties observed at the outset did not diminish with practice. [less ▲]

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See detailCompte rendu de "Plotin, Traité 12 (II, 4), Introduction, traduction, commentaires et notes par Elena Perdikouri"
Gavray, Marc-Antoine ULg

in Revue Philosophique de la France et de l'Etranger (2016), (2), 281-282

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See detailUnveiling Network and Service Performance Degradation in the Wild with mPlane
Casas, Pedro; Fiadino, Pierdomenico; Wassermann, Sarah ULg et al

in IEEE Communications Magazine - Network Testing Series (2016)

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity ... [more ▼]

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity. However, its distributed nature leads to operational brittleness and difficulty in identifying the root causes of performance degradation. In such a context, network measurements are a fundamental pillar to shed light and to unveil design and implementation defects. To tackle this fragmentation and visibility problem, we have recently conceived mPlane, a distributed measurement platform which runs, collects and analyses traffic measurements to study the operation and functioning of the Internet. In this paper, we show the potentiality of the mPlane approach to unveil network and service degradation issues in live, operational networks, involving both fixed-line and cellular networks. In particular, we combine active and passive measurements to troubleshoot problems in end-customer Internet access connections, or to automatically detect and diagnose anomalies in Internet-scale services (e.g., YouTube) which impact a large number of end-users. [less ▲]

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See detailPHYTOCHEMICAL ANALYSIS OF FUMARIA OFFICINALIS L. (FUMARIACEAE)
Paltinean, Ramona; Toiu, Anca; Wauters, Jean-Noël ULg et al

in Farmacia (2016), 64(3), 409-413

The present study describes the investigation of active compounds from several samples of Fumaria officinalis L. (Fumariaceae). The identification of the isoquinoline alkaloids (allocryptopine ... [more ▼]

The present study describes the investigation of active compounds from several samples of Fumaria officinalis L. (Fumariaceae). The identification of the isoquinoline alkaloids (allocryptopine, chelidonine, protopine, bicuculline, sanguinarine, cheleritrine, stylopine and hydrastine) was performed by comparison with reference standards using an HPLC-DAD method, and their quantification by LC-DAD and spectrophotometric methods. The presence of polyphenolic compounds was simultaneously assessed by HPLC. Protopine and sanguinarine were identified in all extracts. The major alkaloids were protopine and chelidonine (258.3 mg/100 g and respectively 94.13 mg/100 g). The spectrophotometric determinations of alkaloids showed minor differences between commercial samples and those harvested from spontaneous flora. The concentration of isoquinoline alkaloids expressed in chelidonine was between 0.69 and 0.76% in all samples. The pattern of phenol carboxylic acids showed the presence of cynarin, chlorogenic, isochlorogenic and ferulic acids. The flavonoids isovitexin, rutin, isoquercitrin and quercitrin were found in all assessed samples of Fumaria officinalis aerial parts. [less ▲]

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See detailBacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons.
Gladwyn-Ng, Ivan ULg; Huang, Lieven; Ngo, Linh et al

in Neural development (2016), 11

BACKGROUND: The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their ... [more ▼]

BACKGROUND: The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiation and dendritic spine connectivity. The RhoA GTPases Rnd2 and Rnd3 are important for neurogenesis and cell migration within the embryonic cortex (Nat Commun 4:1635, 2013), and we recently identified the BTB/POZ domain-containing Adaptor for Cul3-mediated RhoA Degradation family member Bacurd2 (also known as Tnfaip1) as an interacting partner to Rnd2 for the migration of embryonic mouse cortical neurons (Neural Dev 10:9, 2015). FINDINGS: We have extended this work and report that Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd2 and Rnd3 in vitro. Given that these genes are expressed during cortical development, we performed a series of in utero electroporation studies in mice and found that disruptions to Bacurd1/Kctd13 or Bacurd2/Tnfaip1 expression impair the long-term positioning of E14.5-born cortical neurons within the postnatal (P17) mouse cerebral cortex. We also find that forced expression of Bacurd1/Kctd13 and Bacurd2/Tnfaip1 alters the branching and dendritic spine properties of layer II/III projection neurons. CONCLUSIONS: We identify Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to Rnd proteins which influence the development of cortical neurons. Their neurodevelopmental functions are likely to be relevant to human brain development and disease. [less ▲]

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See detailHow do cumulative live birth rates and cumulative multiple live birth rates over complete courses of assisted reproductive technology treatment per woman compare among registries?
De Neubourg, Diane; Bogaerts, Kris; Blockeel, Christophe et al

in Human Reproduction (2016)

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See detailAirewater interfacial properties of enzymatic wheat gluten hydrolyzates determine their foaming behavior
Wouters, Arno G.B.; Rombouts, Ine; Legein, Marie et al

in Food Hydrocolloids (2016), 55

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different ... [more ▼]

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different peptic and tryptic wheat gluten hydrolyzates were related to the kinetics of their adsorption at an airewater interface as well as to the properties of a compressed protein film at this interface. Foams from degree of hydrolysis (DH, i.e. the percentage of cleaved peptide bonds) 2 hydrolyzates were more stable than those from their DH 6 counterparts, and this at all protein concentrations tested. However, at protein concentrations from 0.010% to 0.050% (wprot/v), peptic DH 2 and 6 hydrolyzates had better foaming stability than their tryptic counterparts of the same DH. The opposite was observed when protein concentrations ranged from 0.050% to 0.150% (wprot/v). These observations can in part be explained by the molecular mass composition of the samples and, more importantly, by high levels of hydrophobic peptides in the DH 2 samples. The calculation of an average elasticity (up to 20e25 mN/m) from the variation in surface pressure for a variation in surface area in Langmuir isotherms showed that DH 2 samples had higher elasticity than DH 6 samples, which was in agreement with their foaming stabilities at various protein concentrations. Additionally, although not usually considered in literature, it seemed there was a correspondence between surface pressure at different protein surface concentrations and foaming stability at different protein concentrations. [less ▲]

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See detailVAN LIMBERGHEN, G. (dir.), Misbruik- en fraudebestrijding in het sociaal recht, Anvers, Intersentia, 2015, 269 p.
Kéfer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2016)

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See detailAssessment of methods of detection of water estrogenicity for their use as monitoring tools in a process of estrogenicity removal
Blavier; Songulashvili; Simon, Coraline ULg et al

in Environmental Technology (2016)

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See detailPotential of copper-tolerant grasses to implement phytostabilisation strategies on polluted soils in South D. R. Congo: Poaceae candidates for phytostabilisation
Boisson, Sylvain ULg; Le Stradic, Soizig ULg; Collignon, Julien et al

in Environmental Science and Pollution Research (2016)

Phytostabilisation (i.e. using plants to immobilise contaminants) represents a well-known technology to hamper heavy metal spread across landscapes. In Katanga (D. R. Congo), Microchloa altera, a tolerant ... [more ▼]

Phytostabilisation (i.e. using plants to immobilise contaminants) represents a well-known technology to hamper heavy metal spread across landscapes. In Katanga (D. R. Congo), Microchloa altera, a tolerant grass from the copper hills, was recently identified as a candidate species to stabilise copper in the soil. More than 50 grasses compose this flora, which may be studied to implement phytostabilisation strategies. However, little is known about their phenology, tolerance, reproductive strategy or demography. The present study aims to characterize the other Poaceae that may be used in phytostabilisation purposes based on the following criteria: their ecological distribution, seed production at two times, abundance, soil coverage and the germination percentage of their seeds. We selected seven perennial Poaceae that occur on the copper hills. Their ecological distributions (i.e. species response curves) have been modelled along copper or cobalt gradients with generalized additive models using logic link based on 172 presence/absence samples on three sites. For other variables, a total of 69 quadrats (1 m2) were randomly placed across three sites and habitats. For each species, we compared the number of inflorescence-bearing stems (IBS) by plot, the percentage of cover, the number of seeds by IBS and the estimated number of seeds by plot between sites and habitat. Three species (Andropogon schirensis, Eragrostis racemosa and Loudetia simplex) were very interesting for phytostabilisation programs. They produced a large quantity of seeds and had the highest percentage of cover. However, A. schirensis and L. simplex presented significant variations in the number of seeds and the percentage of cover according to site. [less ▲]

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See detailOptimization of a cheap and residential small-scale production of edible crickets with local by-products as an alternative protein-rich human food source in Ratanakiri Province (Cambodia)
Caparros Megido, Rudy ULg; Alabi, Taofic ULg; Nieus, Clément et al

in Journal of the Science of Food and Agriculture (2016)

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may ... [more ▼]

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may represent a sustainable, cost effective and high quality alternative source of protein to traditional livestock. This study aimed to optimise a cheap and residential cricket breeding system based on unused wild resources. The cricket development, Teleogryllus testaceus (Walker), under seven diets composed of taro aerial parts, young cassava leaves, young cashew leaves and brown rice flour (with or without banana slices), versus a traditionally used broiler feed diet was studied. Results - Cricket mortality was low in all diets, except the two cashew-based diets. Total biomass was significantly higher under the broiler feed, in addition to the two diets containing a combination of cassava leaf powder and brown rice. Yet, crickets fed with the taro diet had the highest percentage of protein. Concerning the breeding system cost, units using cassava leaves were the cheapest ones. Conclusion – Diets based of cassava leaves seems to be the most promising ones. Nevertheless, to produce crickets with a high body mass and a high protein level, a new experiment must be realised in which the cassava leaf maturity will be adapted to fit with the cricket growth stage. Moreover, to reduce the cost of the breeding units, handmade local products should be used instead of purchased components. [less ▲]

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See detailEfficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Fafin, Coraline et al

in Journal of Nephrology (2016), 29(1), 99-103

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies ... [more ▼]

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. Methods In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Results Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m2 and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14–36), 23 (17–31), 31 (22–38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28–44), 35 (29–41), 39 (32–47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/ mL. Conclusions In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D. [less ▲]

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See detailComparison of residual stresses on long rolled profiles measured by X-ray diffraction, ring core and the sectioning methods and simulated by FE method
Bouffioux, Chantal ULg; Pesci, Raphaël; Boman, Romain ULg et al

in Thin-Walled Structures (2016), 104

Sheet piles are produced by hot rolling, a cooling step and, if required, by a straightening operation. Numerical simulations indicate that the stress field is almost homogeneous through the thickness ... [more ▼]

Sheet piles are produced by hot rolling, a cooling step and, if required, by a straightening operation. Numerical simulations indicate that the stress field is almost homogeneous through the thickness, justifying the comparison of X-ray diffraction, ring core and the sectioning methods applied after the cooling step and after the straightening process. The equipment, the steps of the experimental procedures and the results are detailed, showing the limits, the specificities and the advantages of each method. Moreover, the amplitude and the distribution of the stresses along the width of the sections present good agreement with results of numerical simulations. [less ▲]

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See detailVolcanic eruptions boost tropical Pacific biological productivity
Chikamoto, Megumi O.; Timmermann, Axel; Yoshimori, Masakazu et al

in Geophysical Research Letters (2016), 43

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See detailSources of dissolved silica to the fjords of northern Patagonia (44–48°S): the importance of volcanic ash soil distribution and weathering
Vandekerkhove, Elke; Bertrand, Sébastien; Reid, Brian et al

in Earth Surface Processes and Landforms (2016), 41(4), 499-512

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See detailNewt life after fish introduction: extirpation of paedomorphosis in a mountain fish lake and newt use of satellite pools
Denoël, Mathieu ULg; Scime, Patrick; Zambelli, Nicola

in Current Zoology (2016), 62(1), 61-69

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context ... [more ▼]

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context, we determined whether small wetlands, such as pools surrounding fished and fishless lakes, could sustain paedomorphic and metamorphic newts. To this end, we surveyed lakes known historically to sustain Alpine newts (Ichthyosaura alpestris) as well as 35 nearby pools. On the basis of the published records, the only known population exhibiting paedomorphosis in the Swiss Alps was found to be extirpated by salmonid introductions. However, the metamorphs persisted in peripheral pools, paedomorphosis was discovered at a new locality, and overwintering larvae were still present in one of the lakes. These results show the importance of conserving varied aquatic habitats such as pools in mountainous environments where the main resources can become unsuitable for amphibians because of fish introductions. Pools may also function as reservoirs in maintaining newt populations until programs to remove fish from lakes can be carried out. It is not known if paedomorphs could reappear after fish removal. However, the combined resilience of amphibians after fish removal and the genetic basis for paedomorphosis highlighted in other taxa by previous studies suggest that there is the potential to maintain this intraspecific case of diversity even after its disappearance. [less ▲]

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See detailCompte rendu de l’ouvrage de VANACKER Daniël (éd.), Journal d’une bourgeoise, 1914-1918 : Marguerite Giron
Bechet, Christophe ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2016), XXXVIII(1),

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See detailIdentification and frequencies of cystic fibrosis mutations in central Argentina.
Pepermans, Xavier; Mellado, Soledad; Chialina, Sergio et al

in Clinical biochemistry (2016)

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See detailThe Medium is the Message. Olivier Schrauwen's ‘Arsène Schrauwen’ Beyond Expectations of Autobiography, Colonial History and the Graphic Novel
Crucifix, Benoît ULg; Meesters, Gert

in European Comic Art (2016), 9(1), 24-62

This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the ... [more ▼]

This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the field of comics. First of all, Schrauwen playfully questions the entrenchment of autobiography in the contemporary graphic novel by presenting a wholly fantasized adventure as biographical family history. This play with generic expectations is continued through Schrauwen’s reliance on the tropes of the adventure story and its figuration of the voyage. Arsène Schrauwen also draws on stereotypical images of both Belgium and the Belgian Congo and integrates them into a grotesque narrative so as to question the supposed unicity of the individual and colonial bodies. Last but not least, the book displays a highly self-reflexive approach to comics storytelling, building on a legacy from Flemish comics in order to play with reading conventions, graphic enunciation and abstraction, thereby thematising the perception of the main character. [less ▲]

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See detailParametric Stein operators and variance bounds
Ley, Christophe; Swan, Yvik ULg

in Brazilian Journal of Probability and Statistics (2016)

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See detailInfluence of a long-term storage in anaerobic conditions on Norway spruce (Picea abies, L. Karst.) physical and mechanical wood properties
Riguelle, Simon ULg; Lesire, Cécile ULg; Hebert, Jacques ULg et al

in Wood Material Science & Engineering (2016)

Timber storage is a key aspect of storm damage management. After huge storms, sprinkling storage is usually the most used conservation process but anaerobic storage in sealed silos appears as good ... [more ▼]

Timber storage is a key aspect of storm damage management. After huge storms, sprinkling storage is usually the most used conservation process but anaerobic storage in sealed silos appears as good alternative to preserve wood quality over long periods. This paper investigates the impact of long-term (57 months) storage of Norway spruce logs in anaerobic atmosphere on wood properties. Tests were performed on clear wood specimens and on lumbers to determine the modulus of elasticity (E), the static bending strength (σf) and the dynamic bending strength (K). Storage effects on impregnability and colour variation were also studied. Results show no effect of storage on E, σf and K. The naturally poor impregnability of Norway spruce is not improved by the anaerobic conditions, compared to traditional wet storage. Triangle tests reveal no discernible colour variation between logs that underwent anaerobic storage and the control sample. As a conclusion, despite a mould (Gliocladium solani) frequently observed on logs surface after the storage, the process offers ideal conservation conditions. While overall cost remains the main drawback for using anaerobic storage at large scale, the process can be recommended for high value logs, especially since it has few environmental impacts. [less ▲]

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See detailInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke et al

in Lancet (2016)

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See detailAxillary temperature measurement: a less stressful alternative for hospitalised cats?
Girod, Maud ULg; Vandenheede, Marc ULg; Farnir, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2016), 178(8), 192

Rectal temperature measurement (RTM) can promote stress and defensive behaviour in hospitalised cats. The aim of this study was to assess if axillary temperature measurement (ATM) could be a reliable and ... [more ▼]

Rectal temperature measurement (RTM) can promote stress and defensive behaviour in hospitalised cats. The aim of this study was to assess if axillary temperature measurement (ATM) could be a reliable and less stressful alternative for these animals. In this prospective study, paired rectal and axillary temperatures were measured in 42 cats, either by a veterinarian or a student. To assess the impact of these procedures on the cat's stress state, their heart rate was checked and a cat stress score (CSS) was defined and graded from 1 (relaxed) to 5 (terrified). A moderate correlation was found between RTM and ATM (r=0.52; P<0.0001). RTM was on average 0.9°C (1.6°F) higher than ATM (P<0.0001), although a wide variation was found in the difference between these two measurements (−2.1°C to 3.6°C (−3.8°F to 6.5°F)). ATM failed to identify hypothermia in 25 per cent of the cases and hyperthermia in 19 per cent of the cases but may be considered less stressful than RTM. Indeed, RTM induced a mildly greater increase in heart rate (+6 bpm; P=0.01) and in CSS (+0.2; P=0.001) than ATM. The results were not affected by operator type. In conclusion, RTM should remain the standard method to obtain accurate temperatures in cats. [less ▲]

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See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (deuxième partie)
Léonard, Laura ULg; Caprasse, Olivier; Dieux, Xavier et al

in Revue Critique de Jurisprudence Belge [= RCJB] (2016), (2),

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See detailEfficient standard error formulas of ability estimators with dichotomous item response models
Magis, David ULg

in Psychometrika (2016), 81

This paper focuses on the computation of asymptotic standard errors (ASE) of ability estimators with dichotomous item response models. A general framework is considered and ability estimators are defined ... [more ▼]

This paper focuses on the computation of asymptotic standard errors (ASE) of ability estimators with dichotomous item response models. A general framework is considered and ability estimators are defined from a very restricted set of assumptions and formulas. This approach encompasses most standard methods such as maximum likelihood, weighted likelihood, maximum a posteriori and robust estimators. A general formula for the ASE is derived from the theory of M-estimation. Well-known results are found back as particular cases for the maximum and robust estimators, while new ASE proposals for the weighted likelihood and maximum a posteriori estimators are presented. These new formulas are compared to traditional ones by means of a simulation study under Rasch modeling. [less ▲]

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See detailA roadmap to multifactor dimensionality reduction methods.
Gola, Damian; Mahachie John, Jestinah M.; Van Steen, Kristel ULg et al

in Briefings in Bioinformatics (2016), 17(2), 293-308

Complex diseases are defined to be determined by multiple genetic and environmental factors alone as well as in interactions. To analyze interactions in genetic data, many statistical methods have been ... [more ▼]

Complex diseases are defined to be determined by multiple genetic and environmental factors alone as well as in interactions. To analyze interactions in genetic data, many statistical methods have been suggested, with most of them relying on statistical regression models. Given the known limitations of classical methods, approaches from the machine-learning community have also become attractive. From this latter family, a fast-growing collection of methods emerged that are based on the Multifactor Dimensionality Reduction (MDR) approach. Since its first introduction, MDR has enjoyed great popularity in applications and has been extended and modified multiple times. Based on a literature search, we here provide a systematic and comprehensive overview of these suggested methods. The methods are described in detail, and the availability of implementations is listed. Most recent approaches offer to deal with large-scale data sets and rare variants, which is why we expect these methods to even gain in popularity. [less ▲]

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See detailPolyphenols from Silybum marianum inhibit in vitro the oxidant response of equine neutrophils and myeloperoxidase activity.
Zholobenko, A.; Mouithys-Mickalad, Ange ULg; Modriansky, M. et al

in Journal of Veterinary Pharmacology & Therapeutics (2016)

A recent study showed that silymarin, a standardized extract of S. marianum might be used in the prevention of equine laminitis. We investigated the effects of quercetin and some compounds found in ... [more ▼]

A recent study showed that silymarin, a standardized extract of S. marianum might be used in the prevention of equine laminitis. We investigated the effects of quercetin and some compounds found in silymarin (silybin, taxifolin and dehydrosilybin) on reactive oxygen species (ROS) production and myeloperoxidase (MPO) release by stimulated equine neutrophils (PMNs) and on MPO activity. All compounds (tested between 100 nm and 100 mum) inhibited superoxide anion production by stimulated PMNs in a dose-dependent manner. Dehydrosilybin and quercetin inhibited superoxide production and MPO release from 10 mum. Classical MPO assay showed quercetin as the most potent inhibitor, followed by taxifolin, dehydrosilybin and silybin. SIEFED MPO assay highlighting the binding of tested compounds to MPO showed that only quercetin and taxifolin maintained an efficient inhibition above 90% at 10 mum. Altogether, our results showed a strong inhibition of PMN activation by planar compounds such as quercetin and dehydrosilybin and a strong inhibition of MPO activity by the smallest molecules, quercetin and taxifolin. In conclusion, the compounds from silymarin may be useful for modulating the oxidative response of PMNs, involved in the pathogenesis of laminitis, but further in vivo studies are needed. [less ▲]

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See detailBeyond linguistic and party homogeneity: Determinants of Belgian MPs’ preferences on federalism and state reform
Dodeigne, Jérémy ULg; Gramme, Pierre; Reuchamps, Min et al

in Party Politics : An International Journal for the Study of Political Parties and Political Organizations (2016), Online First

Political parties are often thought of as unitary actors that have consistent preferences. This ‘hidden assumption’ means that heterogeneity within parties, and therefore intra-party dynamics, are often ... [more ▼]

Political parties are often thought of as unitary actors that have consistent preferences. This ‘hidden assumption’ means that heterogeneity within parties, and therefore intra-party dynamics, are often overlooked in explaining attitudes. When it comes to devolution and federalisation, parties or MPs belonging to the same region are also often implicitly considered to have homogeneous viewpoints and attitudes. Relying on an original survey of MPs carried out during the Belgian political gridlock of 2010–2011, this article uncovers some of the key dimensions of the intra-party dynamics through analysis of MPs’ preferences towards institutional reform in Belgium. Far from being explained along party or community lines, our results demonstrate how MPs’ political and sociological background, national/regional identity, political career, and inter-community relations strongly shape their preferences. [less ▲]

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See detailLearning of interval and general type-2 fuzzy logic systems using simulated annealing: Theory and practice
Almaraashi, Majid; John, Robert; Hopgood, Adrian ULg et al

in Information Sciences (2016), 360

This paper reports the use of simulated annealing to design more efficient fuzzy logic systems to model problems with associated uncertainties. Simulated annealing is used within this work as a method for ... [more ▼]

This paper reports the use of simulated annealing to design more efficient fuzzy logic systems to model problems with associated uncertainties. Simulated annealing is used within this work as a method for learning the best configurations of interval and general type-2 fuzzy logic systems to maximize their modeling ability. The combination of simulated annealing with these models is presented in the modeling of four benchmark problems including real-world problems. The type-2 fuzzy logic system models are compared in their ability to model uncertainties associated with these problems. Issues related to this combination between simulated annealing and fuzzy logic systems, including type-2 fuzzy logic systems, are discussed. The results demonstrate that learning the third dimension in type-2 fuzzy sets with a deterministic defuzzifier can add more capability to modeling than interval type-2 fuzzy logic systems. This finding can be seen as an important advance in type-2 fuzzy logic systems research and should increase the level of interest in the modeling applications of general type-2 fuzzy logic systems, despite their greater computational load. [less ▲]

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See detailRecommendations for donation after circulatory death kidney transplantation in Europe.
van Heurn, L. W. Ernest; Talbot, David; Nicholson, Michael L. et al

in Transplant international : official journal of the European Society for Organ Transplantation (2016)

Donation after circulatory death (DCD) donors provides an invaluable source for kidneys for transplantation. Over the last decade, we have observed a substantial increase in the number of DCD kidneys ... [more ▼]

Donation after circulatory death (DCD) donors provides an invaluable source for kidneys for transplantation. Over the last decade, we have observed a substantial increase in the number of DCD kidneys, particularly within Europe. We provide an overview of risk factors associated with DCD kidney function and survival and formulate recommendations from the sixth international conference on organ donation in Paris, for best-practice guidelines. A systematic review of the literature was performed using Ovid Medline, Embase and Cochrane databases. Topics are discussed, including donor selection, organ procurement, organ preservation, recipient selection and transplant management. [less ▲]

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See detailAlong-stream transport and transformation of dissolved organic matter in a large tropical river
Lambert, Thibault ULg; Teodoru, C. R.; Nyoni, F. C. et al

in Biogeosciences (2016), 13(9), 2727--2741

Large rivers transport considerable amounts of terrestrial dissolved organic matter (DOM) to the ocean. However, downstream gradients and temporal variability in DOM fluxes and characteristics are poorly ... [more ▼]

Large rivers transport considerable amounts of terrestrial dissolved organic matter (DOM) to the ocean. However, downstream gradients and temporal variability in DOM fluxes and characteristics are poorly studied at the scale of large river basins, especially in tropical areas. Here, we report longitudinal patterns in DOM content and composition based on absorbance and fluorescence measurements along the Zambezi River and its main tributary, the Kafue River, during two hydrological seasons. During high-flow periods, a greater proportion of aromatic and humic DOM was mobilized along rivers due to the hydrological connectivity with wetlands, while low-flow periods were characterized by lower DOM content of less aromaticity resulting from loss of connectivity with wetlands, more efficient degradation of terrestrial DOM and enhanced autochthonous productivity. Changes in water residence time due to contrasting water discharge were found to modulate the fate of DOM along the river continuum. Thus, high water discharge promotes the transport of terrestrial DOM downstream relative to its degradation, while low water discharge enhances the degradation of DOM during its transport. The longitudinal evolution of DOM was also strongly impacted by a hydrological buffering effect in large reservoirs in which the seasonal variability of DOM fluxes and composition was strongly reduced. [less ▲]

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See detailProtoporphyrin IX Functionalised AgSiO2 Core-shell Nanoparticle: Plasmonic Enhancement of Fluorescence and Singlet Oxygen Production
Lismont, Marjorie ULg; Dreesen, Laurent ULg; Heinrichs, Benoît ULg et al

in Photochemistry & Photobiology (2016), 92

Metal-enhanced processes arising from the coupling of a dye with metallic nanoparticles (NPs) have been widely reported. However, few studies have simultaneously investigated these mechanisms from the ... [more ▼]

Metal-enhanced processes arising from the coupling of a dye with metallic nanoparticles (NPs) have been widely reported. However, few studies have simultaneously investigated these mechanisms from the viewpoint of dye fluorescence and photoactivity. Herein, protoporphyrin IX (PpIX) is grafted onto the surface of silver core silica shell NPs in order to investigate the effect of silver (Ag) localized surface plasmon resonance (LSPR) on PpIX fluorescence and PpIX singlet oxygen (1O2) production. Using two Ag core sizes, we report a systematic study of these photophysical processes as a function of silica (SiO2) spacer thickness, LSPR band position and excitation wavelength. The excitation of Ag NP LSPR, which overlaps the PpIX absorption band, leads to the concomitant enhancement of PpIX fluorescence and 1O2 production independently of the Ag core size, but in a more pronounced way for larger Ag cores. These enhancements result from the increase in the PpIX excitation rate through the LSPR excitation and decrease when the distance between PpIX and Ag NPs increases. A maximum fluorescence enhancement of up to 14-fold, together with an increase in photogenerated 1O2 production of up to five times are obtained using 100 nm Ag cores coated with a 5 nm thick silica coating. [less ▲]

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See detailShear Response of Prestressed Thin-Webbed Continuous Girders
Collins, Michael; Xie, Liping; Mihaylov, Boyan ULg et al

in ACI Structural Journal (2016)

While different design codes provide similar guidance for the flexural design of prestressed thin: webbed continuous girders, the shear design provisions differ greatly. This paper investigates these ... [more ▼]

While different design codes provide similar guidance for the flexural design of prestressed thin: webbed continuous girders, the shear design provisions differ greatly. This paper investigates these discrepancies with the help of eleven experiments and a number of analytical studies. Together these provide the basis for recommendations for engineers conducting the shear design for new girders or evaluating the shear capacity of existing girders. It is shown that the traditional ACI approach of taking Vc as the smaller of Vci, flexural:shear cracking load, and Vcw, web:shear cracking load, can significantly overestimate the shear strength of such girders particularly if they are highly prestressed and contain relatively small quantities of shear reinforcement. The other codes evaluated provided more conservative predictions. It is shown that the ACI predictions can be improved significantly by taking into account the effect of flexural stresses on web shear cracking. While the ACI code uses different shear strength equations for members subjected to external axial loads versus members subjected to internal prestressing forces, the studies summarized in this paper support the idea that unification of these ACI shear provisions is possible. [less ▲]

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See detailLymphocytoses B monoclonales : de la revue de la littérature à la pratique de laboratoire.
KEUTGENS, Aurore ULg; Foguenne, Jacques; Gothot, André ULg et al

in Annales de biologie clinique (2016), 74(2), 168-175

Monoclonal B-cell lymphocytosis (MBL) is defined as an asymptomatic condition characterized by the presence of less than 5,000 monoclonal B-cells per microliter and the absence of clinical signs or ... [more ▼]

Monoclonal B-cell lymphocytosis (MBL) is defined as an asymptomatic condition characterized by the presence of less than 5,000 monoclonal B-cells per microliter and the absence of clinical signs or symptoms of a B-cell lymphoproliferative disorder. Most MBL cases involve B cells presenting an identical phenotype to CLL (CLL-like MBL) with a Catovsky-Matutes score of 3 to 5 and share the same chromosomal abnormalities than CLL. Depending on the absolute B cell count, one may distinguish low-count CLL-like MBL (<500 B cells/muL) which have no evidence of progression, no reduction in overall survival, no increase in infection risk and do not require any specific follow-up. Patients with clinical CLL-like MBL (>500 B cells/muL) have a 1% to 2% per year risk of progression to CLL requiring therapy, a higher risk of infectious complications and mortality implicating an annual follow-up by hematologist. MBL may also express other less common phenotypes and are named atypical MBL in case of CD5 antigen expression (Catovsky-Matutes score: 1-2) and non-CLL-like MBL for CD5 negative cases (Catovsky-Matutes score: 0-2). Their poorer prognosis implicates imaging studies, bone marrow biopsy and cytogenetic analysis in addition to physical examination in order to rule out non-hodgkinien lymphoma, and require a more frequent follow-up. This review focuses on key concepts in the classification, diagnosis, monitoring and biology of MBL in laboratory practice. [less ▲]

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See detailTendances récentes de la recherche en rhétorique
Provenzano, François ULg

in Français Moderne (Le) (2016), 84(2),

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See detailTetraxylopteris Beck emend. Hammond and Berry (2005), the first aneurophytalean genus recorded in Australia
Meyer-Berthaud, Brigitte; Decombeix, Laure; Dunstone, Robert et al

in Review of Palaeobotany and Palynology (2016), 224(Part 1), 54-65

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See detailManaging Chronic Kidney Disease in Older People--Reply
Glassock, rj; DELANAYE, Pierre ULg; El-Nahas, M

in JAMA : Journal of the American Medical Association (2016), 315(3),

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See detailUse of the potential probiotic strain Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers.
Saint-Cyr, Manuel Jimmy; Haddad, Nabila; Taminiau, Bernard ULg et al

in International Journal of Food Microbiology (2016)

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler ... [more ▼]

Campylobacteriosis is the most frequently reported zoonotic disease in humans in the EU since 2005. As chicken meat is the main source of contamination, reducing the level of Campylobacter in broiler chicken will lower the risk to consumers. The aim of this project was to evaluate the ability of Lactobacillus salivarius SMXD51 to control Campylobacter jejuni in broilers and to investigate the mechanisms that could be involved. Thirty broilers artificially contaminated with C. jejuni were treated by oral gavage with MRS broth or a bacterial suspension (107CFU) of Lb. salivarius SMXD51 (SMXD51) in MRS broth. At 14 and 35days of age, Campylobacter and Lb. salivarius loads were assessed in cecal contents. The impact of the treatment on the avian gut microbiota at day 35 was also evaluated. At day 14, the comparison between the control and treated groups showed a significant reduction (P<0.05) of 0.82 log. After 35days, a significant reduction (P<0.001) of 2.81 log in Campylobacter loads was observed and 73% of chickens treated with the culture exhibited Campylobacter loads below 7log10CFU/g. Taxonomic analysis revealed that SMXD51 treatment induced significant changes (P<0.05) in a limited number of bacterial genera of the avian gut microbiota and partially limited the impact of Campylobacter on Anaerotruncus sp. decrease and Subdoligranulum sp. increase. Thus, SMXD51 exhibits an anti-Campylobacter activity in vivo and can partially prevent the impact of Campylobacter on the avian gut microbiota. [less ▲]

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