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See detailHighly dispersed iron xerogel catalysts for p-nitrophenol degradation by photo-Fenton effects
Mahy, Julien ULg; Tasseroul, Ludivine ULg; Zubiaur, Anthony ULg et al

in Microporous and Mesoporous Materials (2014), 197

Several iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ... [more ▼]

Several iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ions. The EDAS/TEOS ratio strongly influences the texture of xerogel catalysts. The specific surface area and the micro- and mesoporous volume increase with this ratio. It seems that EDAS plays a nucleating agent role for silica particles and allows to anchor Fe-based moieties inside the silica network. Iron oxide nanoparticles of diameter 1-1.5 nm and Fe3+ ions result, encapsulated in silica particles with sizes of about 10-30 nm in diameter. The iron species was determined by Mössbauer spectroscopy and magnetometry measurements and only Fe3+ species were observed in xerogel catalysts. The Fenton and photo-Fenton effect of these catalysts were evaluated on the degradation of p-nitrophenol in aqueous media under different conditions. Results show that in the presence of H2O2, iron xerogel catalysts present a photo-Fenton effect, reaching 99 % of degradation after 24 h. [less ▲]

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See detailLa ludicisation des pratiques d’écriture sur Internet : une étude des fanfictions comme dispositifs jouables
Barnabé, Fanny ULg

in Sciences du jeu (2014), 2(Automne),

This paper aims for studying the ludification phenomenon through one of its realizations: the introduction of play in the writing of fan fictions on the Internet. According to the perspective of the "play ... [more ▼]

This paper aims for studying the ludification phenomenon through one of its realizations: the introduction of play in the writing of fan fictions on the Internet. According to the perspective of the "play studies" (Triclot, 2011) and of the "play design" (Genvo, 2008), the ludification is defined here as the generalization of a "playful attitude" observable through the traces (the "signs of playability") it leaves on the objects it appropriates. This work therefore seeks to identify, within a corpus of fan fiction inspired by the videogame series Kingdom Hearts, any marks of the playful use that is made of these texts. The modifications occasioned, in the practice, by the use of digital technology will also be considered (can this "ludogenic" media increase the playability?; Vial, 2012). The fan fiction will successively be considered as a community phenomenon, as a writing practice and, finally, as a set of texts. [less ▲]

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See detailLarval development sites of the main Culicoides species (Diptera: Ceratopogonidae) in northern Europe and distribution of coprophilic species larvae in Belgian pastures
Zimmer, Jean-Yves ULg; Brostaux, Yves ULg; Haubruge, Eric ULg et al

in Veterinary Parasitology (2014), 205(3-4), 676-686

Some Culicoides species of biting midges (Diptera: Ceratopogonidae) are biological virus vectors worldwide and have indeed been associated with outbreaks of important epizoonoses in recent years, such as ... [more ▼]

Some Culicoides species of biting midges (Diptera: Ceratopogonidae) are biological virus vectors worldwide and have indeed been associated with outbreaks of important epizoonoses in recent years, such as bluetongue and Schmallenberg disease in northern Europe. These diseases, which affect domestic and wild ruminants, have caused considerable economic losses. Knowledge of substrates suitable for Culicoides larval development is important, particularly for the main vector temperate species. This study, realized during two years, aimed to highlight the larval development sites of these biting midge species in the immediate surroundings of ten Belgian cattle farms. Moreover, spatial distribution of the coprophilic Culicoides larvae (C. chiopterus and C. dewulfi) within pastures was studied with increasing distance from farms along linear transects (farm–pasture–woodland). A total of 4347 adult specimens belonging to 13 Culicoides species were obtained by incubation of 2131 soil samples belonging to 102 different substrates; 18 of these substrates were suitable for larval development. The Obsoletus complex (formed by two species) was observed in a wide range of substrates, including silage residues, components of a chicken coop, dung adhering to walls inside stables, leftover feed along the feed bunk, a compost pile of sugar beet residues, soil of a livestock trampling area, and decaying wood, while the following served as substrates for the other specimens: C. chiopterus, mainly cow dung; C. dewulfi, cow dung and molehill soil; C. circumscriptus, algae; C. festivipennis, algae and soil in stagnant water; C. nubeculosus, algae and silt specifically from the edge of a pond; C. punctatus, mainly wet soil between silage reserves; C. salinarius, algae; and C. stigma, algae and wet soil between silage reserves. We also recorded significantly higher densities of coprophilic larvae within pastures in cow dung located near forests, which is likely due to the localization of potential hosts; the presence of these larvae within cow dung is, however, uninfluenced by relative distance from farms. A better knowledge of the microhabitats of Culicoides biting midges and their spatial distribution may allow the development of targeted species-specific vector control strategies, and may help to prevent the creation of new larval development sites. [less ▲]

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See detailUnveiling the effects of berenil, a DNA-binding drug, on Trypanosoma cruzi: implications for kDNA ultrastructure and replication.
Zuma, Aline Araujo; Cavalcanti, Danielle Pereira; Zogovich, Marcelo et al

in Parasitology research (2014)

Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits a single mitochondrion with an enlarged portion termed kinetoplast. This unique structure harbors the mitochondrial DNA (kDNA ... [more ▼]

Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits a single mitochondrion with an enlarged portion termed kinetoplast. This unique structure harbors the mitochondrial DNA (kDNA), composed of interlocked molecules: minicircles and maxicircles. kDNA is a hallmark of kinetoplastids and for this reason constitutes a valuable target in chemotherapeutic and cell biology studies. In the present work, we analyzed the effects of berenil, a minor-groove-binding agent that acts preferentially at the kDNA, thereby affecting cell proliferation, ultrastructure, and mitochondrial activity of T. cruzi epimastigote form. Our results showed that berenil promoted a reduction on parasite growth when high concentrations were used; however, cell viability was not affected. This compound caused significant changes in kDNA arrangement, including the appearance of membrane profiles in the network and electron-lucent areas in the kinetoplast matrix, but nuclear ultrastructure was not modified. The use of the TdT technique, which specifically labels DNA, conjugated to atomic force microscopy analysis indicates that berenil prevents the minicircle decatenation of the network, thus impairing DNA replication and culminating in the appearance of dyskinetoplastic cells. Alterations in the kinetoplast network may be associated with kDNA lesions, as suggested by the quantitative PCR (qPCR) technique. Furthermore, parasites treated with berenil presented higher levels of reactive oxygen species and a slight decrease in the mitochondrial membrane potential and oxygen consumption. Taken together, our results reveal that this DNA-binding drug mainly affects kDNA topology and replication, reinforcing the idea that the kinetoplast represents a potential target for chemotherapy against trypanosomatids. [less ▲]

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See detailDissociation Pathways of Benzylpyridinium “Thermometer” Ions Depend on the Activation Regime: An IRMPD Spectroscopy Study
Morsa, Denis ULg; Gabelica, Valérie ULg; Rosu, Frédéric et al

in Journal of Physical Chemistry Letters (2014), 5

The dissociation of benzylpyridinium “thermometer” ions is widely used to calibrate the internal energy of ions produced in mass spectrometry. The fragmentation mechanism is usually believed to yield a ... [more ▼]

The dissociation of benzylpyridinium “thermometer” ions is widely used to calibrate the internal energy of ions produced in mass spectrometry. The fragmentation mechanism is usually believed to yield a benzylium cation, although recent studies suggest the possibility of a rearrangement leading to the tropylium isomer, which would compromise the accuracy of energy calibrations. In this study, we used IRMPD spectroscopy to probe the dissociation pathways of the p-(tert-butyl)- benzylpyridinium ion. Our results show that the formation of both benzylium and tropylium products is feasible depending on the activation regime and on the reaction time scale. Varying the trapping delays in the hexapole gives insight into a rearrangement mechanism occurring through consecutive reactions with an isomerization from benzylium to tropylium. Our work provides experimental validations for the established calibration procedure and highlights the adequacy of IRMPD spectroscopy to qualitatively resolve gas-phase rearrangement kinetics. [less ▲]

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See detailEGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
Paye, Alexandra ULg; Truong, Alice ULg; Yip, Cassandre ULg et al

in Cancer Research (2014), 74(23), 6758-70

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of ... [more ▼]

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of cancer cell proliferation through CDK4 activation and retinoblastoma protein (Rb) inactivation. We also determine a functional link between MT4-MMP and the growth factor receptor EGFR. Mechanistic experiments revealed direct association of MT4-MMP and its positive effects on EGFR phosphorylation in response to TGF- and EGF in cancer cells. Notably, the effects of MT4-MMP on proliferation and EGFR activation did not rely on metalloprotease activity. Clinically, MT4-MMP and EGFR expression were correlated in human triple negative breast cancer specimens. Altogether our results identify MT4-MMP as a positive modifier of EGFR outside-in signaling that acts to cooperatively drive cancer cell proliferation. [less ▲]

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See detailPCR-RFLP identification of the endangered Pyrenean desman, Galemys pyrenaicus (Soricomorpha, Talpidae), based on faecal DNA
Gillet, François ULg; Cabria Garrido, Maria Teresa; Némoz, Mélanie et al

in Mammalia (2014)

The Pyrenean desman is a vulnerable mammal species endemic to Pyrenees and the northern Iberian Peninsula. The presence of this elusive species can be most easily detected by sampling its faeces. However ... [more ▼]

The Pyrenean desman is a vulnerable mammal species endemic to Pyrenees and the northern Iberian Peninsula. The presence of this elusive species can be most easily detected by sampling its faeces. However, these faecal samples can be confused with those of other vertebrate species living in the same habitats. This study provides two easy and reliable methods for the identification of the Pyrenean desman faeces based on genetic analyses. The first one consists of a nested PCR and sequencing of a mitochondrial cytochrome b fragment, and the second one is an enzymatic digestion with endonucleases Alu I and Sau 3AI. The restriction patterns given by the two enzymes were found suitable for the successful discrimination of the Pyrenean desman from the other species based on species-specific sequence variations. [less ▲]

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See detailEtiology in Parthenius of Nicaea
Vandersmissen, Marc ULg

in Euphrosyne (2014), 42

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See detailImpact of vocal load on breathiness: Perceptual evaluation
Remacle, Angélique ULg; Schoentgen, Jean; FINCK, Camille ULg et al

in Logopedics, Phoniatrics, Vocology (2014), 39(3), 139-146

Objectives: To evaluate the impact on voice of 2 hours of continuous oral reading. Methods: Fifty normophonic women underwent two sessions of voice loading in which the required intensity level varied: 60 ... [more ▼]

Objectives: To evaluate the impact on voice of 2 hours of continuous oral reading. Methods: Fifty normophonic women underwent two sessions of voice loading in which the required intensity level varied: 60-65 dB(A) for the first session, and 70-75 dB(A) for the second session. Ten expert judges evaluated the breathiness of one sentence recorded before and after each loading session. Pairs of stimuli were presented randomly to the judges, who were asked to designate the breathiest sample. Results: A significant decrease in breathiness was observed following both sessions, suggesting an improvement of voice subsequent to loading. When comparing the two intensity levels, no difference was found for breathiness after vocal loading. [less ▲]

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See detailL’ANATOMIE REVISITÉE DU PETIT BASSIN
Bonnet, Pierre ULg

in Louvain Medical (2014), 133(8), 3-13

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des ... [more ▼]

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des parois latérales au sein de l’espace endopelvien, leur innervation dépend d’une double origine, abdominale et pelvienne. Les parois de cet espace abritent les nerfs somatiques et vaisseaux destinés aux parois de la partie inférieure du tronc et aux membres inférieurs. La connaissance pratique de cette anatomie peut être aidée par une approche constructive élaborant les parois et ensuite le contenu de cet espace. [less ▲]

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See detailValidation des paramètres de marche par un système accélérométrique (Locométrix*) à l'aide d'un système opto-électronique 3D (Coda Motion )
GILLAIN, Sophie ULg; Schwartz, Cédric ULg; Boutaayamou, Mohamed ULg et al

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2014), 12(supplément 3),

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See detailNeurophysiology of hypnosis
VANHAUDENHUYSE, Audrey ULg; Laureys, Steven ULg; Faymonville, Marie-Elisabeth ULg

in Clinical Neurophysiology (2014), 44

We here review behavioral, neuroimaging and electrophysiological studies of hypnosis as a state, as well as hypnosis as a tool to modulate brain responses to painful stimulations. Studies have shown that ... [more ▼]

We here review behavioral, neuroimaging and electrophysiological studies of hypnosis as a state, as well as hypnosis as a tool to modulate brain responses to painful stimulations. Studies have shown that hypnotic processes modify internal (self awareness) as well as external (environmental awareness) brain networks. Brain mechanisms underlying the modulation of pain perception under hypnotic conditions involve cortical as well as subcortical areas including anterior cingulate and prefrontal cortices, basal ganglia and thalami. Combined with local anesthesia and conscious sedation in patients undergoing surgery, hypnosis is associated with improved peri- and postoperative comfort of patients and surgeons. Finally, hypnosis can be considered as a useful analogue for simulating conversion and dissociation symptoms in healthy subjects, permitting better characterization of these challenging disorders by producing clinically similar experiences. [less ▲]

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See detailEffect of Corn Substitution by Sorghum Grain with Low Tannin Content on Broilers Production: Animal Performance, Nutrient Digestibility and Carcass Characteristics
Mamadou Tandiang, Diaw; Thiam Diop, Mamadou; Dieng, Abdoulaye et al

in International Journal of Poultry Science (2014), 13(10), 568-574

The effect of substituting corn with sorghum grains with low tannin content (LTC) on broilers performances was investigated in a 6-week feeding trial. Seven hundred fifty 1-day old chicks and not sexed ... [more ▼]

The effect of substituting corn with sorghum grains with low tannin content (LTC) on broilers performances was investigated in a 6-week feeding trial. Seven hundred fifty 1-day old chicks and not sexed Coob 500 were used in this test. These animals were separated into five groups with three replicates of 50 birds for each one. A control diet with 50% of corn was used in the control group. Three other diets where corn was substituted by conventional sorghum in 1/3, 2/3 and 3/3 were given respectively to the G1/3, G2/3 and G3/3 groups. The GLTC groups received diets with total substitution of maize by sorghum with LTC. No significant difference was shown for the body weight between the control and the GLTC groups (respectively 1303 and 1418 g). But the use of conventional sorghum decreases significantly the broilers weight live (p>0.05) with the lower weight performances (1128 to 1225 g). Mortalities were similar for the different groups. It’s always results to climatic environment which was identical for the different group. No difference has been observed for the carcass dressing percentage (68 to 76%). For the nutrients digestibility, except the fat matter which was difference and higher (more than 92%), dry matter, ash and then metabolizable energy were similar (p>0.05) in the starting and growing diets. [less ▲]

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See detailLa régulation médicale et la chaîne de secours: La problèmatique des transferts primo-secondaires le modèle Belge en général et son application en province de Liège en particulier
BRASSEUR, Edmond ULg; GHUYSEN, Alexandre ULg; D'Orio, Vincenzo ULg

in Revue Médicale de Liège (2014), 68(10), 536-540

Medical regulation represents an essential tool for emergency medical assistance. Even if it is essentially based on a 1964 law, our medical regulation is constantly evolving to meet the present needs and ... [more ▼]

Medical regulation represents an essential tool for emergency medical assistance. Even if it is essentially based on a 1964 law, our medical regulation is constantly evolving to meet the present needs and to follow the medical and technological advances. In this article, we shall outline its major components and evoke some long-awaited developments in the field of public health. [less ▲]

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See detailL'amiodarone et la thyroïde
Brescia, Lionel ULg; Benoit, Arnaud ULg; BETEA, Daniela ULg et al

in Revue Médicale de Liège (2014), 69(10), 549-554

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See detailDynamic Simulation of Large-scale Power Systems Using a Parallel Schur-complement-based Decomposition Method
Aristidou, Petros ULg; Fabozzi, Davide; Van Cutsem, Thierry ULg

in IEEE Transactions on Parallel and Distributed Systems (2014), 25(10), 2561-2570

Power system dynamic simulations are crucial for the operation of electric power systems as they provide important information on the dynamic evolution of the system after an occurring disturbance. This ... [more ▼]

Power system dynamic simulations are crucial for the operation of electric power systems as they provide important information on the dynamic evolution of the system after an occurring disturbance. This paper proposes a robust, accurate and efficient parallel algorithm based on the Schur complement domain decomposition method. The algorithm provides numerical and computational acceleration of the procedure. Based on the shared-memory parallel programming model, a parallel implementation of the proposed algorithm is presented. The implementation is general, portable and scalable on inexpensive, shared-memory, multi-core machines. Two realistic test systems, a medium-scale and a large-scale, are used for performance evaluation of the proposed method. [less ▲]

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See detailMapping track density changes in nigrostriatal and extranigral pathways in Parkinson's disease
Ziegler, Erik ULg; Rouillard, Maud; André, Elodie et al

in NeuroImage (2014), 99

Highlights First whole-brain probabilistic tractography study in Parkinson's disease High quality diffusion-weighted images (120 gradient directions, b = 2500 s/mm2) Voxel-based group analysis comparing ... [more ▼]

Highlights First whole-brain probabilistic tractography study in Parkinson's disease High quality diffusion-weighted images (120 gradient directions, b = 2500 s/mm2) Voxel-based group analysis comparing early-stage patients and controls Abnormal reconstructed track density in the nigrostriatal pathway and brainstem Track density also increased in limbic and cognitive circuits. [less ▲]

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See detailTime for reasoning ICS prescription in obstructive airway diseases.
Louis, Renaud ULg; Demarche, Sophie ULg

in International journal of clinical practice (2014), 68(10), 1176-8

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See detailEditorial
Jidovtseff, Boris ULg

in Sciences et Sports - Journal des Sciences et de la Médecine de l'Homme en mouvement (2014), 29(Hors-série 1), 1

There are a number of positive challenges for Physical Education. Recent chearch shows that physical activity has a powerfull impact on the structure and functioning of the brain that opens up important ... [more ▼]

There are a number of positive challenges for Physical Education. Recent chearch shows that physical activity has a powerfull impact on the structure and functioning of the brain that opens up important avenues for research and practice. [less ▲]

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See detail2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).
Elliott, Perry M.; Anastasakis, Aris; Borger, Michael A. et al

in European heart journal (2014), 35(39), 2733-79

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See detailMuscle Mitochondrial Dysfunction in Horses Affected by Acute Laminitis
Serteyn, Didier ULg; de la Rebière de Pouyade, Geoffroy ULg; Sandersen, Charlotte ULg et al

in Bioenergetics (2014)

Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes ... [more ▼]

Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes leading to the failure of the dermal-epidermal interface. The aim of this study was to measure the muscle mitochondrial function by high resolution respirometry. Muscle micro-biopsies were obtained from 11 horses affected by acute metabolic laminitis, 6 horses affected by acute laminitis resulting from a systemic inflammation response syndrome and 28 healthy horses distributed in 2 control groups: 17 horses with a body condition score [BSC, ranging from 0 (emaciated) to 5 (obese)] of 2 to 3 and 11 horses with a BSC of 4 to 5. During the acute phase of laminitis, a significant reduction of the muscle mitochondrial respiration was observed. The muscle mitochondrial dysfunction occurred independently of the etiology (metabolic disorder or systemic inflammation) leading to laminitis. The reduction of the oxidative phosphorylation and of the maximal respiratory capacity (after uncoupling) may induce depletion of the cell’s ATP content. If the same mitochondrial alteration occurs in the foot lamina, mitochondria targeting should be considered for the future, not only to better understand the physiopathology of the disease but also to maintain and to support the mitochondrial function before reaching the « mitochondrial dysfunction threshold » that may lead to the failure of the dermal-epidermal interface. [less ▲]

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See detailPalynological record of the Silurian/Devonian boundary in the Argentine Precordillera, western Gondwana
Garcia Muro, V.J.; Rubinstein, C.V.; Steemans, Philippe ULg

in Neues Jahrbuch für Geologie und Palaontologie. Abhandlungen (2014), 274(1), 25-42

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See detailPelouses calcaires : une application de la portance écologique pour le renforcement du réseau écologique
Hendrickx, Sébastien ULg; Van Der Kaa, Claire ULg; Sérusiaux, Emmanuël ULg

in Notes de recherche - Conférence Permanente du Développement Territorial Région Wallonne (2014), 48

La méthodologie d’évaluation de la portance écologique du territoire a ensuite été paramétrée afin d'objectiver l’intérêt du territoire wallon du point de vue des pelouses calcaires. Il résulte de cette ... [more ▼]

La méthodologie d’évaluation de la portance écologique du territoire a ensuite été paramétrée afin d'objectiver l’intérêt du territoire wallon du point de vue des pelouses calcaires. Il résulte de cette application un outil cartographique qui permet de discriminer les sites potentiels les plus efficaces pour la restauration de ces pelouses sur le plan écologique. Cet exercice démontre ainsi très concrètement l'utilité de la portance écologique en tant qu'aide à la décision pour orienter les dépenses de préservation de leur réseau écologique spécifique. [less ▲]

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See detailLe médicament du mois Combinaison fixe périndopril-indapamide-amlodipine (Triplixam®) pour le traitement de l’hypertension artérielle
SCHEEN, André ULg; LANCELLOTTI, Patrizio ULg; KRZESINSKI, Jean-Marie ULg

in Revue Médicale de Liège (2014), 69(10), 565-570

Triplixam® is a fixed dose combination of three well known antihypertensive agents, with complementary activities, to control blood pressure in patients with arterial hypertension : perindopril, an ... [more ▼]

Triplixam® is a fixed dose combination of three well known antihypertensive agents, with complementary activities, to control blood pressure in patients with arterial hypertension : perindopril, an angiotensin converting enzyme inhibitor, indapamide, un diuretic whith thiazide-like effects but also specific properties, and amlodipine, a long-acting calcium antagonist of the dihydropyridine family. The potential synergic action allows better control of blood pressure with once daily administration, while limiting the incidence of adverse events. Various presentations with different dosages are available to facilitate individualized therapy. Warnings and precautions for use of every molecule should of course be respected. Such a fixed dose combination should contribute to limit clinical inertia and to improve therapeutic compliance. [less ▲]

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See detailIsolation and cultivation of xylanolytic and cellulolytic Sarocladium kiliense and Trichoderma virens from the gut of the termite Reticulitermes santonensis
Tarayre, Cédric ULg; Bauwens, Julien ULg; Brasseur, Catherine ULg et al

in Environmental Science & Pollution Research (2014)

The purpose of this work was the isolation and cultivation of cellulolytic and xylanolytic microorganisms extracted from the gut of the lower termite Reticulitermes santonensis. Microcrystalline cellulose ... [more ▼]

The purpose of this work was the isolation and cultivation of cellulolytic and xylanolytic microorganisms extracted from the gut of the lower termite Reticulitermes santonensis. Microcrystalline cellulose (with and without lignin) and beech wood xylan were used as diets instead of poplar wood in order to select cellulose and hemicellulose-degrading fungi. The strain Sarocladium kiliense (Acremonium kiliense) CTGxxyl was isolated from the termites fed on xylan, while the strain Trichoderma virens CTGxAviL was isolated from the termites fed on cellulose (with and without lignin). Both molds were cultivated in liquid media containing different substrates: agro-residues or purified polymers. S. kiliense produced maximal β-glucosidase, endo-1,4-β-D-glucanase, exo-1,4-β-D-glucanase and endo-1,4-β-D-xylanase activities of 0.103, 3.99, 0.53, and 40.8 IU/ml, respectively. T. virens produced maximal β-xylosidase, endo-1,4-β-D-glucanase, exo-1,4-β-D-glucanase, and endo-1,4-β-D-xylanase activities of 0.38, 1.48, 0.69, and 426 IU/ml. The cellulase and the xylanase of S. kiliense, less common than T. virens, were further investigated. The optimal activity of the xylanase was observed at pH 9–10 at 60 °C. The cellulase showed its maximal activity at pH 10, 70 °C. Zymography identified different xylanases produced by both molds, and some fragment sizes were highlighted: 35, 100, and 170 kDa for S. kiliense and 20, 40, 80, and 170 kDa for T. virens. In both cases, endo-1,4-β-D-xylanase activitieswere confirmed through mass spectrometry. [less ▲]

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See detailComment je traite … recommandations pour instaurer un traitement medicamenteux
SCHEEN, André ULg

in Revue Médicale de Liège (2014), 69(10), 526-530

Initiating a new pharmacological therapy is an important step in the global medical approach. Such a decision is the final step of a careful reasoning and should respect some rules in order to guarantee ... [more ▼]

Initiating a new pharmacological therapy is an important step in the global medical approach. Such a decision is the final step of a careful reasoning and should respect some rules in order to guarantee the best efficacy, but also safety for the patient. Clinical inertia should be avoided, but the essential principles of the evidence based medicine should also be taken into account. This concise article summarizes the main fundamental rules and cautions that should be respected by any clinician when initiating a new pharmacological therapy. [less ▲]

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See detailSystematic analysis of site-specific yield distributions resulting from nitrogen management and climatic variability interactions
Dumont, Benjamin ULg; Basso, Bruno; Leemans, Vincent ULg et al

in Precision Agriculture (2014)

At the plot level, crop simulation models such as STICS have the potential to evaluate risk associated with management practices. In nitrogen (N) management, however, the decision-making process is ... [more ▼]

At the plot level, crop simulation models such as STICS have the potential to evaluate risk associated with management practices. In nitrogen (N) management, however, the decision-making process is complex because the decision has to be taken without any knowledge of future weather conditions. The objective of this paper is to present a general methodology for assessing yield variability linked to climatic uncertainty and variable N rate strategies. The STICS model was coupled with the LARS-Weather Generator. The Pearson system and coefficients were used to characterise the shape of yield distribution. Alternatives to classical statistical tests were proposed for assessing the normality of distributions and conducting comparisons (namely, the Jarque-Bera and Wilcoxon tests, respectively). Finally, the focus was put on the probability risk assessment, which remains a key point within the decision process. The simulation results showed that, based on current N application practice among Belgian farmers (60 60 60 kgN ha-1), yield distribution was very highly significantly non normal, with the highest degree of asymmetry characterised by a skewness value of -1.02. They showed that this strategy gave the greatest probability (60%) of achieving yields that were superior to the mean (10.5 t ha-1) of the distribution. [less ▲]

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See detailEccentric muscle contractions: risks and benefits
Hody, Stéphanie ULg; Croisier, Jean-Louis ULg; Lacrosse, Zoé ULg et al

in Proceedings of the Belgian Royal Academies of Medicine (2014)

La contraction musculaire excentrique se caractérise par le développement d'une tension musculaire associée à l'étirement concomitant du complexe musculo-tendineux. Ce mode de contraction présente un ... [more ▼]

La contraction musculaire excentrique se caractérise par le développement d'une tension musculaire associée à l'étirement concomitant du complexe musculo-tendineux. Ce mode de contraction présente un intérêt croissant dans de nombreux domaines tels que l’entraînement sportif, la médecine physique et la rééducation. De plus, certaines indications de l’entraînement en mode excentrique ont été posées chez des patients porteurs de maladies chroniques. Cependant, lorsqu’il est réalisé de manière intense et inhabituelle, l’exercice excentrique peut entraîner diverses altérations de l’ultrastructure musculaire qui se manifestent par une série de symptômes cliniques comme des douleurs musculaires d’apparition retardées (Delayed-Onset Muscle Soreness, DOMS) et une altération de la fonction musculaire. Malgré la littérature abondante consacrée à la description du phénomène des DOMS, aucune théorie cohérente n’est actuellement disponible pour expliquer la survenue différée des sensations douloureuses et des signes associés. De même, toujours à l’analyse de la littérature, on ne peut que constater l’absence de solution thérapeutique susceptible d’atténuer significativement l’intensité des DOMS et de leurs conséquences fonctionnelles associées à l’exception, paradoxalement, de l’exercice excentrique lui-même qui, lorsqu’il est proposé en conditions sous-maximales d’intensité progressivement croissante, semble constituer la seule prévention réellement efficace de l’apparition des DOMS. De même, si l’efficacité d’un entraînement spécifique dans la prévention des DOMS a été confirmée par de nombreux travaux, la nature de cet effet protecteur reste sujette à conjectures. Nous sommes néanmoins convaincus qu’une meilleure compréhension des réponses aiguës et/ou adaptatives à l’exercice excentrique contribuerait d’une part, à la mise au point d’interventions thérapeutiques efficaces et d’autre part, à élucider les évènements moléculaires impliqués dans des conditions pathologiques telles que les myalgies et certaines maladies neuromusculaires. [less ▲]

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See detailSwallowing in disorders of consciousness
Bicego, Aminata; Lejoly, Kelly ULg; Maudoux, Audrey et al

in Revue Neurologique (2014), 170(10),

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See detailManagement of the neonate at risk for early-onset Group B streptococcal disease (GBS EOD): new paediatric guidelines in Belgium
MAHIEU, Ludo; LANGHENDRIES, Jean Paul; COSSEY, Veerle et al

in Acta Clinica Belgica (2014), 69(5), 313-319

Despite group B streptococcal (GBS) screening in late pregnancy and intrapartum antimicrobial prophylaxis, early onset sepsis in neonates remains a common source of neonatal morbidity and mortality ... [more ▼]

Despite group B streptococcal (GBS) screening in late pregnancy and intrapartum antimicrobial prophylaxis, early onset sepsis in neonates remains a common source of neonatal morbidity and mortality especially in preterm neonates. The identification of neonates with early onset sepsis is usually based on perinatal risk factors. Clinical signs are aspecific and laboratory tests not sensitive. Therefore, many clinicians will overtreat at risk infants. Inappropriate treatment with antibiotics increases the risk for late onset sepsis, necrotizing enterocolitis, mortality and prolongs hospitalisation and costs. In 2003, the Belgian Health Council (BHC), published guidelines for the prevention of perinatal GBS infections. This report presents the Belgian paediatric management guidelines, which have been endorsed by the Belgian and Flemish societies of neonatology and paediatrics. The most imported changes in the 2014 guidelines are the following: · recommendations for a lumbar puncture, · clarification of normal spinal fluid parameters and blood neutrophil indices corrected for gestation age, · specific timing for diagnostic testing after birth, · no indication for diagnostic testing in asymptomatic newborns unless additional risk factors, · a revised algorithm for management of neonates according to maternal and neonatal risk factors, · premature infants described as those below 35 weeks instead of 37 weeks The guidelines were made on the basis of the best evidence and on expert opinion when inadequate evidence exists. [less ▲]

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See detailWASP-104b and WASP-106b: two transiting hot Jupiters in 1.75-day and 9.3-day orbits
Smith, A. M. S.; Anderson, D. R.; Armstrong, D. J. et al

in Astronomy and Astrophysics (2014)

We report the discovery from the WASP survey of two exoplanetary systems, each consisting of a Jupiter-sized planet transiting an 11th magnitude (V) main-sequence star. WASP-104b orbits its star in 1.75 d ... [more ▼]

We report the discovery from the WASP survey of two exoplanetary systems, each consisting of a Jupiter-sized planet transiting an 11th magnitude (V) main-sequence star. WASP-104b orbits its star in 1.75 d, whereas WASP-106b has the fourth-longest orbital period of any planet discovered by means of transits observed from the ground, orbiting every 9.29 d. Each planet is more massive than Jupiter (WASP-104b has a mass of 1.27±0.05 MJup, while WASP-106b has a mass of 1.93±0.08 MJup). Both planets are just slightly larger than Jupiter, with radii of 1.14±0.04 and 1.09±0.04 RJup for WASP-104 and WASP-106 respectively. No significant orbital eccentricity is detected in either system, and while this is not surprising in the case of the short-period WASP-104b, it is interesting in the case of WASP-106b, because many otherwise similar planets are known to have eccentric orbits. [less ▲]

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See detailInvestigation on Convective Drying of Mixtures of Sewage Sludge and Sawdust in a Fixed Bed
Li, Jie ULg; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Drying Technology (2014)

This work is a part of a project aiming at developing a renewable fuel for gasification purposes, through convective drying of sludge/wood mixtures. The first step consists of characterizing the behavior ... [more ▼]

This work is a part of a project aiming at developing a renewable fuel for gasification purposes, through convective drying of sludge/wood mixtures. The first step consists of characterizing the behavior of sawdust/sludge mixtures during the application of convective drying. The influence of the mixing step (no mixing against 30 s at 40 rpm), as well as the sawdust/sludge ratio (1/9, 2/8, 3/7 and 4/6 on a dry basis) and the effect of the drying temperature (50 °C, 80 °C and 110 °C) have been investigated. In this study, X-ray tomography, a non-invasive imaging technique, is used to assess changes in the volume, void and exchange surface at the beginning and the end of the drying process. Results first confirm the importance of the mixing step on the drying behavior: the drying rate of the mixed sludge is lower than that of the original sludge. Nevertheless the addition of sawdust is shown to have a positive impact on the drying process from a mass ratio of 2/8, with drying rates higher than that of the original sludge. With increasing amount of sawdust, the initial and final bed volumes, initial and final total exchange surfaces, and initial void fraction increase linearly, but the bed volume shrinkage and final void fraction decrease linearly. [less ▲]

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See detailPour l'amour du grec : le voyage de Villoison en Grèce et au Levant (1784-1786)
Famerie, Etienne ULg

in Art&Fact (2014), 33

How the French scholar d'Ansse de Villoison describes, analyses and judges the state of Ottoman Greece in the end of the 18th century

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See detailL'identification dans le travail avec les familles, réflexion clinique
Malchair, Alain ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2014), 16

Le travail avec les familles est indispensable en pédopsychiatrie, qu'il s'agisse de thérapie familiale ou d'accompagnement familial. Dans cette communication, nous réfléchissons à la place de l ... [more ▼]

Le travail avec les familles est indispensable en pédopsychiatrie, qu'il s'agisse de thérapie familiale ou d'accompagnement familial. Dans cette communication, nous réfléchissons à la place de l'identification projective dans toute rencontre thérapeutique avec une famille en souffrance, sur base d'un travail clinique avec des parents dont un des enfants est handicapé par le syndrome de Prader Willi. Actuellement, l'identification projective est considérée comme un mécanisme normal et important du fonctionnement des parents et des thérapeutes. La clinique du handicap nous montre la grande difficulté des parents à entrer dans ce processus lorsque leur enfant réel est si loin de l'enfant attendu. [less ▲]

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See detailJosé Muñoz: La poética de las manchas
Dejasse, Erwin ULg

in Entre Líneas: Revista de Estudios Sobre Historieta y Humor Gráfico (2014), 1

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See detailKepler detection of a new extreme planetary system orbiting the subdwarf-B pulsator KIC 10001893
Silvotti, R.; Charpinet, S.; Green, E.M. et al

in Astronomy and Astrophysics (2014), 570

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See detailDevenir art-thérapeute
Vandeninden, Elise ULg

in SociologieS (2014)

In the field of mental health workers, a new profession is emerging: animators of art workshops in psychiatry, also called ‘art therapists’. Our paper reveals the results of a survey conducted in Belgium ... [more ▼]

In the field of mental health workers, a new profession is emerging: animators of art workshops in psychiatry, also called ‘art therapists’. Our paper reveals the results of a survey conducted in Belgium among these new professionals. In portraying this new group of ‘distributed’ workers, we will discuss the reasons for their difficult process of professionalization [less ▲]

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See detailRetrospective analysis of a suburban out-ofhours clinic in Belgium
Belche, Jean-Luc ULg; Berrewaerts, Marie-Astrid ULg; Burette, Philippe ULg et al

in Acta Clinica Belgica (2014), 69(5), 341-347

Introduction: In many countries, out-of-hours medical care is under scrutiny. The aim of this article is to study the activities recorded by the first out-of-hours clinic that has been opened, as a pilot ... [more ▼]

Introduction: In many countries, out-of-hours medical care is under scrutiny. The aim of this article is to study the activities recorded by the first out-of-hours clinic that has been opened, as a pilot study, in two Walloon communes. Material and method: A retrospective analysis of anonymized data was conducted for 2009. Coding of diagnoses was conducted using the International Classification of Primary Care (ICPC-2). Results: A total of 3949 contacts were recorded in 2009 with the out-of-hours clinic, 3294 related to inhabitants of the two communes covered, which was equivalent to 13% of the total population in question. Compared to 7.2% of contacts between midnight and 8 a.m., 82.9% of contacts took place between 8 a.m. and 9 p.m., and 91.6% of contacts were handled locally, with only 8.4% resulting in hospitalization. In addition, 52% of contacts were with patients aged between 25 and 65; 29.9% of contacts were with paediatric patients (,15 years). Patients over the age of 65 made up 18% of contacts. The most common pathologies were respiratory (R). Analysis of flu diagnoses identified two epidemic peaks. Discussion: The suburban out-of-hours clinic studied fulfilled an important role in managing the demand for health care. The large majority of health problems were resolved locally, and the inhabitants did not need to go to hospital. Appointments between midnight and 8 a.m. were in the minority, which points towards adjusting the organization of the out-of-hours service during the night. The geriatric population is not highly over-represented contrary to what might be expected considering its largest number of pathologies. The on-call doctor’s skills profile should take account of the populations and morbidities encountered. Out-ofhours clinics could possibly play a sentinel role in terms of flu epidemics. Conclusion: This study describes a pilot suburban out-of-hours clinic which met three of recommendations set by the KCE in its report on out-of-hours care in general medicine: the organization of an out-of-hours clinic with logistical support, the use of a single telephone number and merging out-of-hours areas. While debate exists on the management of out-of-hours care, this study provides evidence on the role of the physician during these hours. [less ▲]

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See detailPSI Mehler reaction is the main alternative photosynthetic electron pathway in Symbiodinium sp., symbiotic dinoflagellates of cnidarians
Roberty, Stéphane ULg; Bailleul, Benjamin ULg; Berne, Nicolas et al

in New Phytologist (2014), 204(1), 81-91

• Photosynthetic organisms have evolved various photoprotective and regulatory mechanisms to cope with changing and high light intensities. The nature and relative amplitude of these mechanisms is matter ... [more ▼]

• Photosynthetic organisms have evolved various photoprotective and regulatory mechanisms to cope with changing and high light intensities. The nature and relative amplitude of these mechanisms is matter of debate in dinoflagellates that live in symbiosis with cnidarians. In this work, the amplitude of photosynthetic alternative electron flows to oxygen (chlororespiration, Mehler reaction, mitochondrial respiration) and PSI cyclic electron flow were investigated in Symbiodinium clades A1, B1 and F1. • Cultured Symbiodinium strains were maintained semi-continuously under identical environmental conditions. Joint measurements of oxygen evolution, fluorescence emission, and absorption changes at specific wavelengths were used to evaluate PSI and PSII electron transfer rates (ETR). • A light-dependent and O2-dependent ETR was observed in all strains. This ETR involved PSII and PSI and was insensitive to addition of mitochondrial and carbon fixation inhibitors. • These results demonstrate that photoreduction of oxygen downstream of PSI by the so-called Mehler reaction is the main alternative electron sink at the onset and steady state of photosynthesis in all strains. This mechanism in Symbiodinium sustains significant levels of photosynthetic electron flux under high light, thus acting as a photoprotective mechanism and increasing the ATP/NADPH ratio by the electron transfer chain. [less ▲]

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See detailAn asymptotic expansion-based method for a spectral approach in equivalent statistical linearization
Canor, Thomas ULg; Blaise, Nicolas ULg; Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2014), 38

Equivalent linearization consists in replacing a nonlinear system with an equivalent linear one whose parameters are tuned with regard to the minimization of a suitable function. In particular, the ... [more ▼]

Equivalent linearization consists in replacing a nonlinear system with an equivalent linear one whose parameters are tuned with regard to the minimization of a suitable function. In particular, the Gaussian equivalent linearization expresses the properties of an equivalent linear system in terms of the mean vector and the covariance matrix of the responses, which are the unknowns of the optimization problem in a spectral approach. Even though the system has been linearized, the resulting set of equations is nonlinear. The computational effort in this method pertains to the solution of a possibly large set of nonlinear algebraic equations involving integrals and inversions of full matrices. This work proposes to develop and apply an asymptotic expansion-based method to facilitate and to improve the statistical linearization for large nonlinear structures. The proposed developments demonstrate that for slightly to moderately coupled nonlinear systems, the equivalent linearization can be applied with an appropriate modal approach and eventually seen as a convergent series initiated with the stochastic response of a main decoupled linear system. With this method, the computational effort is attractively reduced, the conditioning of the set of nonlinear algebraic equations is improved and inversion of full transfer matrices and repeated integrations are avoided. The paper gives a formal description of the method and illustrates its implementation and performances with the computation of stationary responses of nonlinear structures subject to coherent random excitation fields. [less ▲]

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See detailMathematical Modeling of HIV Dynamics After Antiretroviral Therapy Initiation: A Review
Rivadeneira, Pablo; Moog, Claude; Stan, Guy-Bart et al

in BioResearch Open Acces (2014), 3(5), 233-241

This review shows the potential ground-breaking impact that mathematical tools may have in the analysis and the understanding of the HIV dynamics. In the first part, early diagnosis of immunological ... [more ▼]

This review shows the potential ground-breaking impact that mathematical tools may have in the analysis and the understanding of the HIV dynamics. In the first part, early diagnosis of immunological failure is inferred from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This method is supported by clinical research results from an original clinical trial: data just after 1 month following therapy initiation are used to carry out the model identification. The diagnosis is shown to be consistent with results from monitoring of the patients after 6 months. In the second part of this review, prospective research results are given for the design of individual anti-HIV treatments optimizing the recovery of the immune system and minimizing side effects. In this respect, two methods are discussed. The first one combines HIV population dynamics with pharmacokinetics and pharmacodynamics models to generate drug treatments using impulsive control systems. The second one is based on optimal control theory and uses a recently published differential equation to model the side effects produced by highly active antiretroviral therapy therapies. The main advantage of these revisited methods is that the drug treatment is computed directly in amounts of drugs, which is easier to interpret by physicians and patients. [less ▲]

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See detailEditorial
Jidovtseff, Boris ULg

in Science et sports (2014), 29(Hors-série 1), 2

Il y a un grand nombre d'aspects positifs dans l'éducation physique. Des études récentes montre que l'activité physique influence positivement le développement et le fonctionnement du cerveau, ouvrant des ... [more ▼]

Il y a un grand nombre d'aspects positifs dans l'éducation physique. Des études récentes montre que l'activité physique influence positivement le développement et le fonctionnement du cerveau, ouvrant des perspectives importantes de recherche mais aussi d'applications pratiques. [less ▲]

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See detailAdditional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: An open trial.
Scantamburlo, Gabrielle ULg; Hansenne, Michel ULg; Geenen, Vincent ULg et al

in European psychiatry : the journal of the Association of European Psychiatrists (2014)

The aim of this open trial was to assess the antidepressant/anxiolytic effects of oxytocin used as an adjunct to antidepressant in treatment-resistant depression. Fourteen patients, who have not responded ... [more ▼]

The aim of this open trial was to assess the antidepressant/anxiolytic effects of oxytocin used as an adjunct to antidepressant in treatment-resistant depression. Fourteen patients, who have not responded to 40mg of escitalopram, received intranasal synthetic oxytocin during 4 weeks, in association with antidepressant. This is the first open trial study suggesting OT in association with escitalopram significantly reduced scores on Hamilton Depression Rating Scale. [less ▲]

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See detailThe impact and retention of spray droplets on a horizontal hydrophobic surface
Zwertvaegher, Ingrid; Verhaeghe, Micheline; Brusselman, Eva et al

in Biosystems Engineering (2014), 126

Spray retention, i.e. the overall capture of spray droplets by plants on initial or subsequent impact, and after loss due to run-off, is an important stage in the spray application process as droplet ... [more ▼]

Spray retention, i.e. the overall capture of spray droplets by plants on initial or subsequent impact, and after loss due to run-off, is an important stage in the spray application process as droplet losses may result in reduced efficacy, economic loss, and environmental contamination. The aim of this exploratory study is to determine whether a new method based on calculating the volumetric proportions per impact type, i.e. adhesion, rebound and shatter, can be used to predict spray retention. These volumetric proportions are calculated based on logistic regression models, derived from vision-based droplet characteristics and impact assessments, and laser-based spray characteristics. The advantages and limitations of such a method are explored. The volumetric proportions per impact type on a horizontal, synthetic hydrophobic surface were determined for four different nozzles (XR 110 01 VS flat-fan nozzle, XR 110 04 VS flat-fan nozzle, XR 110 08 VS flat-fan nozzle and AI 110 08 VS air-induction nozzle) under controlled realistic conditions, and compared to the results of a retention test. The volumetric proportions of adhesion were much lower than the relative retentions, indicating that a considerable amount of rebound and shatter also contributed to final retention. The method should thus be improved by including the droplets retained after first impact and the retained proportions of partial droplet fragmentation but it is nevertheless considered a promising technique. [less ▲]

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See detailMagnetization of 2-G Coils and Artificial Bulks
Coombs, Tim; Fagnard, Jean-François ULg; Matsuda, Koichi

in IEEE Transactions on Applied Superconductivity (2014), 24(5), 8201005

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See detailCalibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Cristol, Jean-Paul et al

in Journal of Nephrology (2014), 27(5), 467-75

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay ... [more ▼]

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results (‘compensated Jaffe method’). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR[60 ml/ min/1.73 m2). Analytical limitations have led to the recommendation to give a grade ([60 ml/min/1.73 m2) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m2 (with MDRD) and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund– Malmo¨ (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated. [less ▲]

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See detailDiscovery and characterization of auxiliary proteins encoded by Simian T-cell Lymphotropic Viruses type 3
Turpin, Jocelyn; Journo, Chloé; Ling Ko, Nga et al

in Journal of Virology (2014)

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See detailPrevenção Quaternária e limites em medicina
Jamoulle, Marc ULg; Gomes, Luis

in Revista Brasileira de Medicina de Família e Comunidade (2014), 9(31),

O conceito de Prevenção Quaternária, um questionamento sobre a base da ação médica, nasceu na articulação da relação médico-paciente. Refere-se a toda a atividade médica, sendo uma importante ferramenta ... [more ▼]

O conceito de Prevenção Quaternária, um questionamento sobre a base da ação médica, nasceu na articulação da relação médico-paciente. Refere-se a toda a atividade médica, sendo uma importante ferramenta para a medicina de família. É uma interrogação ética sobre os excessos da demasiada e demasiadamente pouca medicina e fornece algumas respostas. [less ▲]

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See detailLa Belgique et les conventions internationales du travail
Detienne, Quentin ULg

in Journal des Tribunaux du Travail (2014)

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See detailA case of trichurosis in gilts and fattening pigs
Caron, Yannick ULg; Delleur, Valery ULg; Cassart, Dominique ULg et al

in JMM Case Reports (2014)

Trichuris suis, also called whipworm, is a parasite of the caecum and colon distributed widely and considered as a fairly common parasite in swine. It may be responsible for porcine trichurosis ... [more ▼]

Trichuris suis, also called whipworm, is a parasite of the caecum and colon distributed widely and considered as a fairly common parasite in swine. It may be responsible for porcine trichurosis characterized by diarrhoea, anorexia, growth retardation, dehydration, emaciation and anaemia. This report presents a case of trichurosis diagnosed in a farrow-to-finish Belgian pig herd. The infection was associated with severe and persistent diarrhoea, growth retardation, emaciation and/or anaemia in 10 recently purchased gilts and in fattening pigs. In gilts, levamisole [8 mg/kg body weight] administered once per os gave a good clinical response, as diarrhoea resolved in nine gilts out of 10. In parallel, for these nine gilts, the number of eggs of T. suis/g faeces passed decreased from 12 400 to less than 100 eggs. In fattening pigs, flubendazole (1 mg/kg BW) administrated over 5 days in drinking water allowed a reduction in the number of T. suis eggs/g and was effective against diarrhoea. Although most of the time pig whipworm infections are light and asymptomatic, in some cases when large numbers of worms are present, they can cause watery to bloody diarrhoea that can lead to anaemia. This less frequent disease should not be forgotten in the differential diagnosis of persistent diarrhoea in growing pigs. [less ▲]

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See detailCoordination of alkali metal ions to model branched hexasaccharides dictates fragment yield in MALDI in-source decay with hydrogen abstraction using 5-nitrosalicylic acid as the matrix
Asakawa, Daiki; Smargiasso, Nicolas ULg; De Pauw, Edwin ULg

in Journal of Mass Spectrometry [=JMS] (2014), 49

The differences among MALDI-ISD spectra of hexasaccharides cationized with various alkali metals are reflected in the different stabilities of the ‘hydrogen-deficient’ glycan radical. The stability order ... [more ▼]

The differences among MALDI-ISD spectra of hexasaccharides cationized with various alkali metals are reflected in the different stabilities of the ‘hydrogen-deficient’ glycan radical. The stability order of alkali metal-glycan radical complexes is proportional to the size of the alkali metal cation, K+ > Na+ > Li+. The Coordination of alkali metal ions to model branched hexasaccharides is the major parameter that dictates the fragment yield in MALDI in-source decay with hydrogen abstraction using 5-nitrosalicylic acid as the matrix [less ▲]

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See detailIncreased of exhaled breath condensate neutrophil chemotaxis in acute exacerbation of COPD.
Corhay, Jean-Louis ULg; MOERMANS, Catherine ULg; HENKET, Monique ULg et al

in Respiratory research (2014), 15

BACKGROUND: Neutrophils have been involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Underlying mechanisms of neutrophil accumulation in the airways of stable and exacerbated ... [more ▼]

BACKGROUND: Neutrophils have been involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Underlying mechanisms of neutrophil accumulation in the airways of stable and exacerbated COPD patients are poorly understood. The aim of this study was to assess exhaled breath condensate (EBC) neutrophil chemotactic activity, the level of two chemoattractants for neutrophils (GRO-alpha and LTB4) during the course of an acute exacerbation of COPD (AECOPD). METHODS: 50 ex smoking COPD patients (33 with acute exacerbation and 17 in stable disease) and 20 matched ex smoking healthy controls were compared. EBC was collected by using a commercially available condenser (EcoScreen(R)). EBC neutrophil chemotactic activity (NCA) was assessed by using Boyden microchambers. Chemotactic index (CI) was used to evaluate cell migration. LTB4 and GROalpha levels were measured by a specific enzyme immunoassay in EBC. RESULTS: Stable COPD and outpatients with AECOPD, but not hospitalized with AECOPD, had raised EBC NCA compared to healthy subjects (p < 0.05 and p < 0.01 respectively). In outpatients with AECOPD EBC NCA significantly decreased 6 weeks after the exacerbation. Overall EBC NCA was weakly correlated with sputum neutrophil counts (r = 0.26, p < 0.05). CONCLUSIONS: EBC NCA rose during acute exacerbation of COPD in ambulatory patients and decreased at recovery. While LTB4 seems to play a role both in stable and in exacerbated phase of the disease, the role of GRO-alpha as a chemotactic factor during AECOPD is not clearly established and needs further investigation. [less ▲]

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See detailMepolizumab treatment in patients with severe eosinophilic asthma.
Ortega, Hector G.; Liu, Mark C.; Pavord, Ian D. et al

in The New England journal of medicine (2014), 371(13), 1198-207

BACKGROUND: Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or ... [more ▼]

BACKGROUND: Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids. METHODS: In this randomized, double-blind, double-dummy study, we assigned 576 patients with recurrent asthma exacerbations and evidence of eosinophilic inflammation despite high doses of inhaled glucocorticoids to one of three study groups. Patients were assigned to receive mepolizumab, a humanized monoclonal antibody against interleukin-5, which was administered as either a 75-mg intravenous dose or a 100-mg subcutaneous dose, or placebo every 4 weeks for 32 weeks. The primary outcome was the rate of exacerbations. Other outcomes included the forced expiratory volume in 1 second (FEV1) and scores on the St. George's Respiratory Questionnaire (SGRQ) and the 5-item Asthma Control Questionnaire (ACQ-5). Safety was also assessed. RESULTS: The rate of exacerbations was reduced by 47% (95% confidence interval [CI], 29 to 61) among patients receiving intravenous mepolizumab and by 53% (95% CI, 37 to 65) among those receiving subcutaneous mepolizumab, as compared with those receiving placebo (P<0.001 for both comparisons). Exacerbations necessitating an emergency department visit or hospitalization were reduced by 32% in the group receiving intravenous mepolizumab and by 61% in the group receiving subcutaneous mepolizumab. At week 32, the mean increase from baseline in FEV1 was 100 ml greater in patients receiving intravenous mepolizumab than in those receiving placebo (P=0.02) and 98 ml greater in patients receiving subcutaneous mepolizumab than in those receiving placebo (P=0.03). The improvement from baseline in the SGRQ score was 6.4 points and 7.0 points greater in the intravenous and subcutaneous mepolizumab groups, respectively, than in the placebo group (minimal clinically important change, 4 points), and the improvement in the ACQ-5 score was 0.42 points and 0.44 points greater in the two mepolizumab groups, respectively, than in the placebo group (minimal clinically important change, 0.5 points) (P<0.001 for all comparisons). The safety profile of mepolizumab was similar to that of placebo. CONCLUSIONS: Mepolizumab administered either intravenously or subcutaneously significantly reduced asthma exacerbations and was associated with improvements in markers of asthma control. (Funded by GlaxoSmithKline; MENSA ClinicalTrials.gov number, NCT01691521.). [less ▲]

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See detailTowards understanding wild boar Sus scrofa movement: a synthetic movement ecology approach
Morelle, Kevin ULg; Podgórski, Tomasz; Prévot, Céline et al

in Mammal Review (2014)

In recent decades, the wild boar Sus scrofa has simultaneously increased its population size and colonized new habitats, causing more ecological and socio-economic concern than perhaps any other ungulate ... [more ▼]

In recent decades, the wild boar Sus scrofa has simultaneously increased its population size and colonized new habitats, causing more ecological and socio-economic concern than perhaps any other ungulate species. However, the drivers and mechanisms of the species' spatial ecology remain poorly understood. Thanks to a recently developed framework, the movement ecology of any organism can now be tackled within a consistent and unified theoretical approach. Based on this framework, we reviewed the literature on wild boar movement ecology to assess current knowledge and to identify important gaps. By using important navigational (e.g. olfactory sense) and cognitive (e.g. spatial memory, learning from conspecifics) abilities, wild boar have developed complex movement strategies to cope with external factors. However, there is a lack of detailed information on the role played by the internal state (motivation) and motion capacity in shaping the spatial ability of the species. Specific aspects of the movement ecology of the wild boar, together with its high diet plasticity and its high prolificacy, are probably the most important causes of the rapid spread of wild boar worldwide. We hope our review will inspire other scientists to apply their biological models to the movement ecology paradigms. Furthermore, we suggest that future researchers dealing with the movement ecology of any species should explicitly state the components and interactions of the framework investigated to facilitate further understanding and comparison among studies. [less ▲]

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See detailRisk of death and the economic accessibility at the dialysis therapy for the renal insufficient patients in Lubumbashi city, Democratic Republic of Congo
Mundongo Thamba, Henri; Van Caillie, Didier ULg; Mutach Kapend, Francis et al

in Pan African Medical Journal (The) (2014), 19:61

The last five years, Lubumbashi records the emergence centers of dialysis. We achieved this study to evaluate the risk factors of death for the renal insufficient patients and the economic accessibility ... [more ▼]

The last five years, Lubumbashi records the emergence centers of dialysis. We achieved this study to evaluate the risk factors of death for the renal insufficient patients and the economic accessibility to this peak therapy. A cross sectional study based on a random sample of 53 patients has been completed in 2012. The data is analyzed using the SPSS 19.0 software. A significance level of p < 0.05 and Confidence interval fixed to 95%. The Fischer exact test and the odds ratio have been used. The participation rate was 65.4%. The mean age was 49.49 ± 13.30 years old and 60.4 % were aged > 50 years old. The sex ratio 0.3 women by men was noted. 83% of patients was private versus other category (p<0.05). 66 % are renal insufficient chronic patients versus 34 % of recent renal insufficient patients. 90% of patients were diabetic hypertensive. The patients' monthly income declared was US$ 205 for 52.8% of patients, US $ 525 for 34% patients and US $ 750 for 13.2% of patients versus US $ 1, 270 monthly mean care cost. The deaths are associated statistically with an interruption of the treatment (χ²=9.30, p=0.0022, OR= 8.5) and with the irregularity of treatment (χ²=8.65, p=0.0032, OR=6). Africa in comparison with countries of other continents, to invest in advanced medical equipment is a salutary measure, but the majority of patients are not able to pay the costs of health care. Our results shown that, the dialysis became an ultimate recourse for the renal insufficient patients at Lubumbashi city but the economic accessibility remains a major obstacle. Consequently, it's important to subsidize the health care of these patients. [less ▲]

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See detailOsteochondrosis-Related Gene Expression in Equine Leukocytes Differs among Affected Joints in Foals
Serteyn, Didier ULg; Piquemal, David; Mendoza García, Luis ULg et al

in Journal of biomarkers and diagnosis (2014), 5

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. Previously, differentially expressed genes in leukocytes of OC-affected have ... [more ▼]

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. Previously, differentially expressed genes in leukocytes of OC-affected have been identified and were differentially expressed in horses of different ages when compared to their age-matched controls.As the time course of the development of OC lesions seems to be joint dependent,the aim of this study is to compare in young OCaffected horses (between 8 to 12 months), the different expression of selected genes depending the joints involved.The expression of OC-related genes were analysed by rt-PCR and subsequent statistical analysis (ΔΔCT) in the leukocytes of 30 Belgian Warmblood horses aged between 8 to 12 months divided in groups depending the affected joints (fetlock, hock and stifle).In the three groups, expression of ApoB-3G, MGAT4A, B4GALT6 and PRKCG genes were significantly higher in the OC-affected foals compared to the healthy foals. Based on the profiles of expression ofApoB-3G, Dsh1/Dvl1, Foxl1, Hp, ISG15, Mark2, PPR2A, RUSC2 and WASH1 genes,the localization of the disease can be determined: expression levels of ApoB3G, WASH1 and FOXl1 to identify fetlock, ApoB3G, PPR2A to identify OC-development in the hock and ApoB3G, Dsh1/Dvl1, WASH1, PPP2R1A and Mark2 geneto identify OC-development in the stifle. However at this moment, the rt-PCR analysis of the identified genes as biomarkers gives only diagnostic information. For the future, the profile of expression of these genes could give also some predictive information on the evolution of the disease such as remission or permanent OC-lesions. [less ▲]

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See detailValorization of Tunisian secondary date varieties (Phoenix Dactylifera L.) by hydrothermal treatments : New fiber concentrates with antioxidant properties
Mrabet, Abdessalem; Rodriguez-Gutierrez, Guillermo; Guillen-Bejarano, Rafael et al

in LWT - Food Science and Technology (2014)

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See detailThermo-responsive gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) core–corona nanoparticles as a drug delivery system
Liu, Ji ULg; Detrembleur, Christophe ULg; Hurtgen, Marie et al

in Polymer Chemistry (2014), 5(18), 5289-5299

Core–corona gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) nanoparticles (gold@PVOH-b-PNVCL NPs) were fabricated via an in situ method, where a gold salt was reduced within the macromolecular aqueous ... [more ▼]

Core–corona gold/poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) nanoparticles (gold@PVOH-b-PNVCL NPs) were fabricated via an in situ method, where a gold salt was reduced within the macromolecular aqueous solution. Arrangement of macromolecular chains on the surface of gold cores was studied by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy and infrared spectroscopy. The responsiveness to temperature and the preserved colloidal stability of the gold@PVOH-b-PNVCL NPs above the lower critical solution temperature (LCST) were confirmed by dynamic light scattering and turbidity measurements. The drug loading capacity (DLC of ca. 1.3–2.8 wt%) of the gold@PVOH-b-PNVCL NPs as a drug delivery system (DDS) was tested with Nadolol®, a hydrophilic drug, and the release behaviours were studied at several temperatures. PVOH-b-PNVCL copolymers with an LCST of a few degrees above the biological temperature (37 °C), for example, PVOH180-b-PNVCL110 (LCST of 41 °C), are preferential, due to the slower release at 37 °C, but a faster release at temperatures that are a few degrees higher. The cytocompatibility of the gold@PVOH-b-PNVCL NPs against mouse fibroblastic L929 cells was evaluated via the MTS assay. Cellular uptake within MEL-5 human melanoma cells was studied by confocal laser scanning microscopy, fluorescence-activated cell sorting and TEM techniques and it showed that gold@PVOH-b-PNVCL NPs preferably accumulated within the cellular cytoplasm, with an incubation concentration and period-dependent uptake process. All these results corroborated a general utility of these thermo-responsive gold@PVOH-b-PNVCL NPs for drug delivery and controlled drug release. [less ▲]

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See detailBlock, random and palm-tree amphiphilic fluorinated copolymers: controlled synthesis, surface activity and use as dispersion polymerization stabilizers
Alaimo, David ULg; Beigbeder, Alexandre; Dubois, Philippe et al

in Polymer Chemistry (2014), 5(18), 5273-5282

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See detailMulti-Chromatic Analysis of SAR Images for Coherent Target Detection
Bovenga, Fabio; Barbier, Christian ULg; De Rauw, Dominique ULg et al

in Remote Sensing (2014), 6

This work investigates the possibility of performing target analysis through the Multi-Chromatic Analysis (MCA), a technique that basically explores the information content of sub-band images obtained by ... [more ▼]

This work investigates the possibility of performing target analysis through the Multi-Chromatic Analysis (MCA), a technique that basically explores the information content of sub-band images obtained by processing portions of the range spectrum of a synthetic aperture radar (SAR) image. According to the behavior of the SAR signal at the different sub-bands, MCA allows target classification. Two strategies have been experimented by processing TerraSAR-X images acquired over the Venice Lagoon, Italy: one exploiting the phase of interferometric sub-band pairs, the other using the spectral coherence derived by computing the coherence between sub-band images of a single SAR acquisition. The first approach introduces the concept of frequency-persistent scatterers (FPS), which is complementary to that of the time-persistent scatterers (PS). FPS and PS populations have been derived and analyzed to evaluate the respective characteristics and the physical nature of the targets. Spectral coherence analysis has been applied to vessel detection, according to the property that, in presence of a random distribution of surface scatterers, as for open sea surfaces, spectral coherence is expected to be proportional to sub-band intersection, while in presence of manmade structures it is preserved anyhow. First results show that spectral coherence is well preserved even for very small vessels, and can be used as a complementary information channel to constrain vessel detection in addition to classical Constant False Alarm Rate techniques based on the sole intensity channel. [less ▲]

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See detailChemical Mass Balance model applied to an olfactory annoyance problematic
Clarke, Kevin; Redon, Nathalie; Romain, Anne-Claude ULg et al

in Environmental Science & Technology (2014), Just accepted manuscript(web),

The source-receptor model CMB (Chemical Mass Balance) generally used for air pollution studies is applied for the first time to solve odour signatures issues. The olfactory annoyance perceived at a ... [more ▼]

The source-receptor model CMB (Chemical Mass Balance) generally used for air pollution studies is applied for the first time to solve odour signatures issues. The olfactory annoyance perceived at a receptor site of an industrial area is often the result of a combination of different smells, emitted by several industrial sources. To identify the main responsible for the inconvenience, tools able to determine the contribution of each source directly where the annoyance is perceived are widely developed and deployed. In this work, the contributions of VOC sources, coming from a waste treatment plant containing 3 potential sources of olfactory annoyance (waste storage, production of biogas, and compost piles of green wastes), and perceived at a village located downwind, are studied by chemical analyses. The CMB methodology is applied and the results are finally compared to olfactometric methods, in order to validate whether it is appropriate to use this model for olfactory problems or not. [less ▲]

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See detailDeficiency of Interleukin-1 Receptor-associated Kinase 4 Presenting as Fatal Pseudomonas aeruginosa Bacteremia in Two Siblings.
STERGIOPOULOU, Theodouli ULg; Walsh, Thomas J.; SEGHAYE, Marie-Christine ULg et al

in The Pediatric infectious disease journal (2014)

Interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency is a primary immunodeficiency of innate immunity. This is the case of a previous healthy toddler and his sibling, who both died of fulminant ... [more ▼]

Interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency is a primary immunodeficiency of innate immunity. This is the case of a previous healthy toddler and his sibling, who both died of fulminant sepsis due to Pseudomonas aeruginosa. Subsequent genetic analysis demonstrated IRAK-4 deficiency with compound heterozygous splice mutations. Fulminant fatal Pseudomonas aeruginosa sepsis may be the first manifestation of IRAK-4 deficiency. [less ▲]

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See detailanxiety at the first radiotherapy session for non-metastatic brest cancer: key communication and communication-related predictors
Lewis, Florence; Merckaert, Isabelle; Liénard, Aurore et al

in Radiotherapy & Oncology (2014)

Background and purpose Patients may experience clinically relevant anxiety at their first radiotherapy (RT) sessions. To date, studies have not investigated during/around the RT simulation the key ... [more ▼]

Background and purpose Patients may experience clinically relevant anxiety at their first radiotherapy (RT) sessions. To date, studies have not investigated during/around the RT simulation the key communication and communication-related predictors of this clinically relevant anxiety. Material and methods Breast cancer patients (n = 227) completed visual analog scale (VAS) assessments of anxiety before and after their first RT sessions. Clinically relevant anxiety was defined as having pre- and post-first RT session VAS scores ⩾4 cm. Communication during RT simulation was assessed with content analysis software (LaComm), and communication-related variables around the RT simulation were assessed with questionnaires. Results Clinically relevant anxiety at the first RT session was predicted by lower self-efficacy to communicate with the RT team (OR = 0.65; p = 0.020), the perception of lower support received from the RT team (OR = 0.70; p = 0.020), lower knowledge of RT-associated side effects (OR = 0.95; p = 0.057), and higher use of emotion-focused coping (OR = 1.09; p = 0.013). Conclusions This study provides RT team members with information about potential communication strategies, which may be used to reduce patient anxiety at the first RT session. [less ▲]

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See detailInvestigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis
Giusti, Arnaud ULg; Lagadic, Laurent; Barsi, Alpar et al

in Science of the Total Environment (2014), 493

The hermaphroditic gastropod Lymnaea stagnalis is proposed as a candidate species for the development of OECD guidelines for testing of the reprotoxicity of chemicals, including endocrine active ... [more ▼]

The hermaphroditic gastropod Lymnaea stagnalis is proposed as a candidate species for the development of OECD guidelines for testing of the reprotoxicity of chemicals, including endocrine active substances (EASs). Up to now, only a few putative EASs have been tested for their reproductive toxicity in this species. In this study, we investigate the effects of four EASs with different affinities to the vertebrate estrogen and androgen receptors (chlordecone as an estrogen; cyproterone acetate, fenitrothion and vinclozolin as anti-androgens) on the reproduction of L. stagnalis in a 21-day semi-static test. Testosterone and 17α-ethinylestradiol (EE2) were used as the reference compounds. The tested EASs had no significant effect on growth and survival at the tested concentration ranges (ng to μg/L). Classical reproduction endpoints (i.e., oviposition and fecundity) were not responsive to the tested chemicals, except for chlordecone and 17α-ethinylestradiol, which hampered reproduction from 19.6 μg/L and 17.6 μg/L, respectively. The frequency of polyembryonic eggs, used as an additional endpoint, demonstrated the effects of all compounds except EE2. The molecular pathways, which are involved in such reproduction impairments, remain unknown. Our results suggest that egg quality is a more sensitive endpoint as compared to other reproductive endpoints commonly assessed in mollusk toxicity tests. [less ▲]

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See detailMultiqubit symmetric states with maximally mixed one-qubit reductions
Baguette, Dorian ULg; Bastin, Thierry ULg; Martin, John ULg

in Physical Review. A (2014), 90

We present a comprehensive study of maximally entangled symmetric states of arbitrary numbers of qubits in the sense of the maximal mixedness of the one-qubit reduced density operator. A general criterion ... [more ▼]

We present a comprehensive study of maximally entangled symmetric states of arbitrary numbers of qubits in the sense of the maximal mixedness of the one-qubit reduced density operator. A general criterion is provided to easily identify whether given symmetric states are maximally entangled in that respect or not. We show that these maximally entangled symmetric (MES) states are the only symmetric states for which the expectation value of the associated collective spin of the system vanishes, as well as in corollary the dipole moment of the Husimi function. We establish the link between this kind of maximal entanglement, the anticoherence properties of spin states, and the degree of polarization of light fields. We analyze the relationship between the MES states and the classes of states equivalent through stochastic local operations with classical communication (SLOCC). We provide a nonexistence criterion of MES states within SLOCC classes of qubit states and show in particular that the symmetric Dicke state SLOCC classes never contain such MES states, with the only exception of the balanced Dicke state class for even numbers of qubits. The 4-qubit system is analyzed exhaustively and all MES states of this system are identified and characterized. Finally the entanglement content of MES states is analyzed with respect to the geometric and barycentric measures of entanglement, as well as to the generalized N-tangle. We show that the geometric entanglement of MES states is ensured to be larger than or equal to 1/2, but also that MES states are not in general the symmetric states that maximize the investigated entanglement measures. [less ▲]

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See detailMoult-related changes in the integument, midgut, and digestive gland in the freshwater amphipod gammarus pulex
Trevisan, Mélissa ULg; Leroy, Delphine; Decloux, Nicole ULg et al

in Journal of Crustacean Biology (2014), 34(5), 539-551

On the basis of macroscopic aspects (body and eye colour, lipid droplets), it was possible to sort specimens of Gammarus pulex (Linnaeus, 1758) into five categories that correspond to moult periods and ... [more ▼]

On the basis of macroscopic aspects (body and eye colour, lipid droplets), it was possible to sort specimens of Gammarus pulex (Linnaeus, 1758) into five categories that correspond to moult periods and stages (A, B, C, D1 and D2) based on integument features (tergite cuticle stiffness, layers and thickness). These stages also correspond to changes in digestive tract histology (gut content, cell ultrastructure, and lipid storage). With reference to the pereion tergite integument, this makes it possible to standardize moulting stage terminology and criteria with those applied to decapods while validating a quick, simple, moult-staging method that avoids injury and informs us about the physiology of the whole organism. The moult cycle was very short (about 12-15 days), with a "virtual," practically non-existent, anecdysis or "integument resting period" between post-ecdysis and pre-ecdysis. The pore canals previously known to be "open to the outside" appeared closed at early post-ecdysis by a lipid-rich fillng material that could be responsible for the cuticular waterproofing barrier allowing mineral deposition. In the digestive tract, the main structural changes were late post-ecdysial loss of midgut cells and digestive gland B-cells (probably by extrusion) when restarting the feeding cycle. Pre-ecdysial increase and post-ecdysial decrease in storage lipids are also obvious. We present a quick moult-staging method to sort a great number of G. pulex for physiological or toxicological assays investigating how animals at specific periods of their moult cycle respond to both natural and anthropogenic environmental changes. [less ▲]

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See detailFundamental Limitations of High Contrast Imaging Set by Small Sample Statistics
Mawet, D.; Milli, J.; Wahhaj, Z. et al

in Astrophysical Journal (2014), 792

In this paper, we review the impact of small sample statistics on detection thresholds and corresponding confidence levels (CLs) in high-contrast imaging at small angles. When looking close to the star ... [more ▼]

In this paper, we review the impact of small sample statistics on detection thresholds and corresponding confidence levels (CLs) in high-contrast imaging at small angles. When looking close to the star, the number of resolution elements decreases rapidly toward small angles. This reduction of the number of degrees of freedom dramatically affects CLs and false alarm probabilities. Naively using the same ideal hypothesis and methods as for larger separations, which are well understood and commonly assume Gaussian noise, can yield up to one order of magnitude error in contrast estimations at fixed CL. The statistical penalty exponentially increases toward very small inner working angles. Even at 5-10 resolution elements from the star, false alarm probabilities can be significantly higher than expected. Here we present a rigorous statistical analysis that ensures robustness of the CL, but also imposes a substantial limitation on corresponding achievable detection limits (thus contrast) at small angles. This unavoidable fundamental statistical effect has a significant impact on current coronagraphic and future high-contrast imagers. Finally, the paper concludes with practical recommendations to account for small number statistics when computing the sensitivity to companions at small angles and when exploiting the results of direct imaging planet surveys. [less ▲]

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See detailLAPAROSCOPIC MAGENSTRASSE AND MILL GASTROPLASTY. FIRST RESULTS OF A PROPECTIVE STUDY
DE ROOVER, Arnaud ULg; KOHNEN, Laurent ULg; DE FLINES, Jenny ULg et al

in Obesity Surgery (2014), 25

Abstract Background TheMagenstrasse and Mill (M&M) procedure is a vertical gastroplasty creating a tubular pouch extending from the cardia to the antrum. This “incomplete sleeve” avoids gastric resection ... [more ▼]

Abstract Background TheMagenstrasse and Mill (M&M) procedure is a vertical gastroplasty creating a tubular pouch extending from the cardia to the antrum. This “incomplete sleeve” avoids gastric resection or band placement. In this paper, we report our experience of the laparoscopic approach of the technique in a selected obese population excluding prominent grazer and/or sweet eaters. Material and Methods One hundred patients (39 males, 61 females) underwent the procedure in a prospective trial.Mean age was 40 years (range 18–68). Mean preoperative BMI was 43.2 kg/m2 (range 35–62). Results The procedure was performed by laparoscopy starting with the creation of a circular opening at the junction of antrum and corpus followed by a vertical stapling to the angle of Hiss. Mean duration of the procedure was 67 (range 40– 122) min. No intraoperative complication occurred. Mean hospital stay (SD) was 2.5 (0.9) days. The single postoperative complication consisted in a mild stenosis that responded to endoscopic dilatation. After a mean follow-up of 15 months (range 9–24), mean percentage of excess body weight loss (SD) was 48(14), 59(18) and 68(24)%, respectively at 3, 6, and 12 months. Quality of life appeared satisfactory with a low incidence of gastroesophageal reflux. The procedure was associated with improvement or resolution of diabetes, arterial hypertension, and dyslipemia at 1 year. Conclusions Our experience demonstrated that the M&M procedure could be performed safely laparoscopically. The satisfactory results on weight loss, obesity-associated mordities, and quality of life will need to be confirmed on longer follow-up. [less ▲]

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See detailGuidance on current good radiopharmacy practice for the small-scale preparation of radiopharmaceuticals using automated modules: a European perspective
Aerts, Joël ULg; Ballinger, james; Behe, Martin et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2014), 57

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See detailThe PLATO 2.0 Mission
Rauer, H.; Catala, C.; Aerts, C. et al

in Experimental Astronomy (2014)

PLATO 2.0 has recently been selected for ESA’s M3 launch opportunity (2022/24). Providing accurate key planet parameters (radius, mass, density and age) in statistical numbers, it addresses fundamental ... [more ▼]

PLATO 2.0 has recently been selected for ESA’s M3 launch opportunity (2022/24). Providing accurate key planet parameters (radius, mass, density and age) in statistical numbers, it addresses fundamental questions such as: How do planetary systems form and evolve? Are there other systems with planets like ours, including potentially habitable planets? The PLATO 2.0 instrument consists of 34 small aperture telescopes (32 with 25 s readout cadence and 2 with 2.5 s candence) providing a wide field-of-view (2232 deg 2) and a large photometric magnitude range (4–16 mag). It focusses on bright (4–11 mag) stars in wide fields to detect and characterize planets down to Earth-size by photometric transits, whose masses can then be determined by ground-based radial-velocity follow-up measurements. Asteroseismology will be performed for these bright stars to obtain highly accurate stellar parameters, including masses and ages. The combination of bright targets and asteroseismology results in high accuracy for the bulk planet parameters: 2 %, 4–10 % and 10 % for planet radii, masses and ages, respectively. The planned baseline observing strategy includes two long pointings (2–3 years) to detect and bulk characterize planets reaching into the habitable zone (HZ) of solar-like stars and an additional step-and-stare phase to cover in total about 50 % of the sky. PLATO 2.0 will observe up to 1,000,000 stars and detect and characterize hundreds of small planets, and thousands of planets in the Neptune to gas giant regime out to the HZ. It will therefore provide the first large-scale catalogue of bulk characterized planets with accurate radii, masses, mean densities and ages. This catalogue will include terrestrial planets at intermediate orbital distances, where surface temperatures are moderate. Coverage of this parameter range with statistical numbers of bulk characterized planets is unique to PLATO 2.0. The PLATO 2.0 catalogue allows us to e.g.: - complete our knowledge of planet diversity for low-mass objects, - correlate the planet mean density-orbital distance distribution with predictions from planet formation theories,- constrain the influence of planet migration and scattering on the architecture of multiple systems, and - specify how planet and system parameters change with host star characteristics, such as type, metallicity and age. The catalogue will allow us to study planets and planetary systems at different evolutionary phases. It will further provide a census for small, low-mass planets. This will serve to identify objects which retained their primordial hydrogen atmosphere and in general the typical characteristics of planets in such low-mass, low-density range. Planets detected by PLATO 2.0 will orbit bright stars and many of them will be targets for future atmosphere spectroscopy exploring their atmosphere. Furthermore, the mission has the potential to detect exomoons, planetary rings, binary and Trojan planets. The planetary science possible with PLATO 2.0 is complemented by its impact on stellar and galactic science via asteroseismology as well as light curves of all kinds of variable stars, together with observations of stellar clusters of different ages. This will allow us to improve stellar models and study stellar activity. A large number of well-known ages from red giant stars will probe the structure and evolution of our Galaxy. Asteroseismic ages of bright stars for different phases of stellar evolution allow calibrating stellar age-rotation relationships. Together with the results of ESA’s Gaia mission, the results of PLATO 2.0 will provide a huge legacy to planetary, stellar and galactic science. [less ▲]

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See detailArmoring a droplet: Soft jamming of a dense granular interface
Lagubeau, Guillaume ULg; Rescaglio, Antonella; Melo, Francesco

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2014), 90

Droplets and bubbles protected by armors of particles have found vast applications in encapsulation, stabilization of emulsions and foams, or flotation processes. The liquid phase stores capillary energy ... [more ▼]

Droplets and bubbles protected by armors of particles have found vast applications in encapsulation, stabilization of emulsions and foams, or flotation processes. The liquid phase stores capillary energy, while concurrently the solid contacts of the granular network induce friction and energy dissipation, leading to hybrid interfaces of combined properties. By means of nonintrusive tensiometric methods and structural measurements, we distinguish three surface phases of increasing rigidity during the evaporation of armored droplets. The emergence of surface rigidity is reminiscent of jamming of granular matter, but it occurs differently since it is marked by a step by step hardening under surface compression. These results show that the concept of the effective surface tension remains useful only below the first jamming transition. Beyond this point, the surface stresses become anisotropic. [less ▲]

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See detailHow (not) to perform ecosystem service valuation - Pricing Gorillas in the Mist -
Boeraeve, Fanny ULg; Dendoncker, Nicolas; Jacobs, Sander et al

in Biodiversity and Conservation (2014)

Monetary valuation of ecosystem services (ES) is gaining growing interest in scientific papers, policies and awareness-raising documents for its potential as a communication tool illustrating the societal ... [more ▼]

Monetary valuation of ecosystem services (ES) is gaining growing interest in scientific papers, policies and awareness-raising documents for its potential as a communication tool illustrating the societal importance of biodiversity. However, simultaneously, its limitations are increasingly discussed in the literature. In this paper we argue that monetary valuation of ES should be seen as representing only one component of ES valuations. We provide basic standards to ensure integrated approaches to ES valuation that can effectively contribute to preserving cultural and biological diversity by acknowledging boundaries to resource exploitation and by building on the various interests and socio-cultural values of involved stakeholders. We base our discussion on a recent study that assesses the economic value of the world-famous Virunga National Park in the Democratic Republic of Congo, home to some of the last mountain gorillas (Gorilla beringei beringei). We alert against some ES monetary valuation that narrowly frames biodiversity conservation in terms of economic calculus and argue that subjugating conservation efforts to profit logics downplays the importance of intrinsic, symbolic and other non-economic values of biodiversity. We conclude by providing principles and methodological guidelines to enhance ES valuation as a tool to promote awareness rising for biodiversity conservation through the understanding the overall importance of biodiversity for human societies. [less ▲]

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See detailThe B Fields in OB Stars (BOB) Survey
Morel, Thierry ULg; Castro, N.; Fossati, L. et al

in The Messenger (2014), 157

The B fields in OB stars (BOB) survey is an ESO Large Programme collecting spectropolarimetric observations for a large number of early-type stars in order to study the occurrence rate, properties, and ... [more ▼]

The B fields in OB stars (BOB) survey is an ESO Large Programme collecting spectropolarimetric observations for a large number of early-type stars in order to study the occurrence rate, properties, and ultimately the origin of magnetic fields in massive stars. A total of 98 objects was observed over 20 nights with FORS2 and HARPSpol to July 2014. Preliminary results indicate that the fraction of magnetic OB stars with an organised, detectable field is low. This conclusion, now independently reached by two different surveys, has profound implications for any theoretical model attempting to explain the field formation in these stars. We also discuss some important issues addressed by our observations (e.g., the lower bound of the field strength) and the discovery of some remarkable objects. [less ▲]

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See detailDiscovery of a Companion Candidate in the HD 169142 Transition Disk and the Possibility of Multiple Planet Formation
Reggiani, Maddalena; Quanz, Sascha P.; Meyer, Michael R. et al

in Astrophysical Journal Letters (2014), 792

We present L'- and J-band high-contrast observations of HD 169142, obtained with the Very Large Telescope/NACO AGPM vector vortex coronagraph and the Gemini Planet Imager, respectively. A source located ... [more ▼]

We present L'- and J-band high-contrast observations of HD 169142, obtained with the Very Large Telescope/NACO AGPM vector vortex coronagraph and the Gemini Planet Imager, respectively. A source located at 0.''156 ± 0.''032 north of the host star (P.A. = 7.4° ± 11.3°) appears in the final reduced L' image. At the distance of the star (~145 pc), this angular separation corresponds to a physical separation of 22.7 ± 4.7 AU, locating the source within the recently resolved inner cavity of the transition disk. The source has a brightness of L' = 12.2 ± 0.5 mag, whereas it is not detected in the J band (J >13.8 mag). If its L' brightness arose solely from the photosphere of a companion and given the J - L' color constraints, it would correspond to a 28-32 MJup object at the age of the star, according to the COND models. Ongoing accretion activity of the star suggests, however, that gas is left in the inner disk cavity from which the companion could also be accreting. In this case, the object could be lower in mass and its luminosity enhanced by the accretion process and by a circumplanetary disk. A lower-mass object is more consistent with the observed cavity width. Finally, the observations enable us to place an upper limit on the L'-band flux of a second companion candidate orbiting in the disk annular gap at ~50 AU, as suggested by millimeter observations. If the second companion is also confirmed, HD 169142 might be forming a planetary system, with at least two companions opening gaps and possibly interacting with each other. [less ▲]

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See detailImmunovirologic Evaluation of Triomune (Lamivudine, Stavudine and Nevirapine) Antiretroviral Therapy in First Line HIV-1 Adult Patients in N’Djamena, Chad
Adawaye, Chatté Idekhim ULg

in Immunovirologic Evaluation of Triomune (Lamivudine, Stavudine and Nevirapine) Antiretroviral Therapy in First Line HIV-1 Adult Patients in N’Djamena, Chad (2014), 4

Dans cet article, nous avons évalué les taux des lymphocytes TCD4 et les charges virales chez des patients Vivant avec le VIH sous Triomune, à N'Djaména au Tchad. Cette évaluation a lieu au J0 avant le ... [more ▼]

Dans cet article, nous avons évalué les taux des lymphocytes TCD4 et les charges virales chez des patients Vivant avec le VIH sous Triomune, à N'Djaména au Tchad. Cette évaluation a lieu au J0 avant le traitement et après huit (8) mois de traitement. Nous avons remarqué que le taux d'échec à la Triomune était de 43,75% (21/48). [less ▲]

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See detailModulated X-ray emission of the magnetic O8.5V-star Tr16-22
Nazé, Yaël ULg; Wade, Gregg A.; Petit, Véronique

in Astronomy and Astrophysics (2014), 569

Using an extensive X-ray dataset, we analyzed the X-ray emission of the massive O-star Tr16-22, which was recently found to be magnetic. Its bright X-ray emission is found to be modulated with a ~54 d ... [more ▼]

Using an extensive X-ray dataset, we analyzed the X-ray emission of the massive O-star Tr16-22, which was recently found to be magnetic. Its bright X-ray emission is found to be modulated with a ~54 d period. This timescale should represent the rotational timescale of the star, as it does for other magnetic massive stars. In parallel, new spectropolarimetric data confirm the published magnetic detection. Based on observations collected with the ESA science mission XMM-Newton, Chandra, and ESO-FORS2 instrument.Tables 1-3 are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424416/olm">http://www.aanda.org</A> [less ▲]

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See detailPhase resolved X-ray spectroscopy of HDE 228766: Probing the wind of an extreme Of+/WNLha star (Corrigendum)
Rauw, Grégor ULg; Mahy, Laurent; Nazé, Yaël ULg et al

in Astronomy and Astrophysics (2014), 569

Based on observations collected with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA member states and the USA (NASA), and on data collected at the San Pedro ... [more ▼]

Based on observations collected with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA member states and the USA (NASA), and on data collected at the San Pedro Mártir observatory (Mexico). Corrigendum [less ▲]

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See detailPlanets and Stellar Activity: Hide and Seek in the CoRoT-7 system
Haywood, R. D.; Cameron, A. C.; Queloz, D. et al

in Monthly Notices of the Royal Astronomical Society (2014), 443(3), 2517-2531

Since the discovery of the transiting Super-Earth CoRoT-7b, several investigations have been made of the number and precise masses of planets present in the system, but they all yield different results ... [more ▼]

Since the discovery of the transiting Super-Earth CoRoT-7b, several investigations have been made of the number and precise masses of planets present in the system, but they all yield different results, owing to the star's high level of activity. Radial velocity (RV) variations induced by stellar activity therefore need to be modelled and removed to allow a reliable detection of all planets in the system. We re-observed CoRoT-7 in January 2012 with both HARPS and the CoRoT satellite, so that we now have the benefit of simultaneous RV and photometric data. We fitted the off-transit variations in the CoRoT lightcurve using a harmonic decomposition similar to that implemented in Queloz et al. (2009). This fit was then used to model the stellar RV contribution, according to the methods described by Aigrain et al. (2011). This model was incorporated into a Monte Carlo Markov Chain in order to make a precise determination of the orbits of CoRoT-7b and CoRoT-7c. We also assess the evidence for the presence of one or two additional planetary companions. [less ▲]

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See detailProper use of Schwarzschild Ledoux criteria in stellar evolution computations
Gabriel, Maurice; Noels-Grötsch, Arlette ULg; Montalbán, J. et al

in Astronomy and Astrophysics (2014), 569

The era of detailed asteroseismic analyses opened by space missions such as CoRoT and Kepler has highlighted the need for stellar models devoid of numerical inaccuracies, in order to be able to diagnose ... [more ▼]

The era of detailed asteroseismic analyses opened by space missions such as CoRoT and Kepler has highlighted the need for stellar models devoid of numerical inaccuracies, in order to be able to diagnose which physical aspects are being ignored or poorly treated in standard stellar modeling. We tackle here the important problem of fixing convective zone boundaries in the frame of the local mixing length theory. First we show that the only correct way to locate a convective zone boundary is to find, at each iteration step, through interpolations or extrapolations from points within the convective zone, the mass where the radiative luminosity is equal to the total luminosity. We then discuss two misuses of the boundary condition and the ways they affect stellar modeling and stellar evolution. The first consists in applying the neutrality condition for convective instability on the radiative side of the convective boundary. The second way of misusing the boundary condition comes from the process of fixing the convective boundary through the search for a change of sign of a possibly discontinuous function. We show that these misuses can lead to completely wrong estimates of convective core sizes with important consequences for the following evolutionary phases. We point out the advantages of using a double mesh point at each convective zone boundary. The specific problem of a convective shell is discussed and some remarks concerning overshooting are given. [less ▲]

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See detailElastic damage to crack transition in a coupled non-local implicit discontinuous Galerkin/extrinsic cohesive law framework
Wu, Ling ULg; Becker, Gauthier ULg; Noels, Ludovic ULg

in Computer Methods in Applied Mechanics & Engineering (2014), 279

One current challenge related to computational fracture mechanics is the modeling of ductile fracture and in particular the damage to crack transition. On the one hand, continuum damage models, especially ... [more ▼]

One current challenge related to computational fracture mechanics is the modeling of ductile fracture and in particular the damage to crack transition. On the one hand, continuum damage models, especially in their non-local formulation which avoids the loss of solution uniqueness, can capture the material degradation process up to the localization of the damage, but are unable to represent a discontinuity in the structure. On the other hand cohesive zone methods can represent the process zone at the crack tip governing the crack propagation, but cannot account for the diffuse material damaging process. In this paper we propose to combine, in a small deformations setting, a non-local elastic damage model with a cohesive zone model. This combination is formulated within a discontinuous Galerkin nite element discretization. Indeed this DG weak formulation can easily be developed in a non-local implicit form and naturally embeds interface elements that can be used to integrate the traction separation law of the cohesive zone model. The method remains thus consistent and computationally e cient as compared to other cohesive element approaches. The effects of the damage to crack transition and of the mesh discretization are respectively studied on the compact tension specimen and on the double-notched specimen, demonstrating the efficiency and accuracy of the method. [less ▲]

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See detailOn the role of pressure in elasto-inertial turbulence
Terrapon, Vincent ULg; Dubief, Yves; Soria, Julio

in Journal of Turbulence (2014), 16(1), 26-43

The dynamics of elasto-inertial turbulence is investigated numerically from the perspective of the coupling between polymer dynamics and flow structures. In particular, direct numerical simulations of ... [more ▼]

The dynamics of elasto-inertial turbulence is investigated numerically from the perspective of the coupling between polymer dynamics and flow structures. In particular, direct numerical simulations of channel flow with Reynolds numbers ranging from 1000 to 6000 are used to study the formation and dynamics of elastic instabilities and their effects on the flow. Based on the splitting of the pressure into inertial and polymeric contributions, it is shown that the polymeric pressure is a non-negligible component of the total pressure fluctuations, although the rapid inertial part dominates. Unlike Newtonian flows, the slow inertial part is almost negligible in elasto-inertial turbulence. Statistics on the different terms of the Reynolds stress transport equation also illustrate the energy transfers between polymers and turbulence and the redistributive role of pressure. Finally, the trains of cylindrical structures around sheets of high polymer extension that are characteristics of elasto-inertial turbulence are shown to be correlated with the polymeric pressure fluctuations. [less ▲]

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See detailLes "PAPS "   Un projet visant à augmenter l’activité physique scolaire des enfants dans l’enseignement primaire
Cloes, Stéphanie; Cloes, Marc ULg

in Science & Sports (2014), 29(Hors-série 1), 53

Starting from Brain Breaks (HopSports) and during a teaching internship activity, the first author implemented one project of movement breaks (PAPS) in a class of 1st grade (6-7 year-old), a class of 5th ... [more ▼]

Starting from Brain Breaks (HopSports) and during a teaching internship activity, the first author implemented one project of movement breaks (PAPS) in a class of 1st grade (6-7 year-old), a class of 5th grade (10-11 year-old) and one of special education (11-15 year-old). PAPS have been proposed one to two times per day pendant periods of 2 to 4 weeks. Pupils' involvement, positive effects informally observed on academic learning and the wish of the pupils to continue the experience would support the interest of the movement breaks. [less ▲]

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See detailLa stratégie chinoise en Amérique latine : entre coopération et hégémonie. Le cas du Brésil
Wintgens, Sophie ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 59(2), 301-336

Cet article part du constat que la Chine a fortement accru sa présence en Amérique latine durant la dernière décennie. Il observe plus précisément que les pays avec lesquels elle a rapidement augmenté ses ... [more ▼]

Cet article part du constat que la Chine a fortement accru sa présence en Amérique latine durant la dernière décennie. Il observe plus précisément que les pays avec lesquels elle a rapidement augmenté ses échanges économiques et commerciaux se sont également engagés dans de nouveaux schémas de coopération et partenariat, posant la question de la Chine comme potentielle « alternative » aux partenaires occidentaux traditionnels de ce sous-continent. Là où nombre d’études s’interrogent sur l’impact des relations sino-latino-américaines, celle-ci propose d’analyser la stratégie chinoise envers l’Amérique latine, en s’appuyant sur le cas du partenariat stratégique avec le Brésil. Dans ce cadre, nous postulons que l’accroissement de l’influence de la Chine dans cette région du monde ne dépend pas seulement de la disponibilité de ses ressources (économiques, politiques, culturelles, militaires, etc.), ni de son aptitude à les mobiliser adéquatement, mais qu’elle tient également à la représentation qu’elle véhicule en tant qu’acteur mondial (coopération Sud-Sud) ainsi qu’à sa reconnaissance par les autres acteurs du système international. En ce sens, la puissance de la Chine se mesure également à travers sa capacité à s’affirmer comme une référence pour ses pairs émergents, voire auprès des puissances occidentales. En appréhendant les différentes dimensions de la puissance chinoise à travers ses actions de politique extérieure et les discours afférents, nous mesurerons dès lors la capacité d’influence de la Chine en Amérique latine, et plus précisément vis-à-vis du Brésil, à travers l’écart entre son discours (coopération) et la réalité (hégémonie). [less ▲]

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See detailZola ethnographe ?
Ledent, David ULg

in Cahiers Naturalistes : Bulletin officiel de la Société Littéraire des Amis d'Emile Zola (2014), 88

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See detailControllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping
Peterchev, Angel; D'Ostilio, Kevin ULg; Rothwell, John et al

in Journal of Neural Engineering (2014), 11(5),

Abstract. Objective. This work aims at flexible and practical pulse parameter control in transcranial magnetic stimulation (TMS), which is currently very limited in commercial devices. Approach. We ... [more ▼]

Abstract. Objective. This work aims at flexible and practical pulse parameter control in transcranial magnetic stimulation (TMS), which is currently very limited in commercial devices. Approach. We present a third generation controllable pulse parameter device (cTMS3) that uses a novel circuit topology with two energy-storage capacitors. It incorporates several implementation and functionality advantages over conventional TMS devices and other devices with advanced pulse shape control. cTMS3 generates lower internal voltage differences and is implemented with transistors with lower voltage rating than prior cTMS devices. Main results. cTMS3 provides more flexible pulse shaping since the circuit topology allows four coil-voltage levels during a pulse, including approximately zero voltage. The nearzero coil voltage enables snubbing of the ringing at the end of the pulse without the need for a separate active snubber circuit. cTMS3 can generate powerful rapid pulse sequences (< 10 ms inter pulse interval) by increasing the width of each subsequent pulse and utilizing the large capacitor energy storage, allowing the implementation of paradigms such as paired-pulse and quadripulse TMS with a single pulse generation circuit. cTMS3 can also generate theta (50 Hz) burst stimulation with predominantly unidirectional electric field pulses. The cTMS3 device functionality and output strength are illustrated with electrical output measurements as well as a study of the effect of pulse width and polarity on the active motor threshold in 10 healthy volunteers. Significance. The cTMS3 features could extend the utility of TMS as a research, diagnostic, and therapeutic tool. [less ▲]

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See detail2014 ESC/ESA Guidelines on Non-cardiac Surgery: Cardiovascular Assessment and Management.
Kristensen, Steen Dalby; Knuuti, Juhani; Saraste, Antti et al

in European Heart Journal (2014), 35(35), 2383-431

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See detailOù il est question de se faire une idée juste de la réalité... (partie 1)
Bruyère, Olivier ULg

in Medi-Sphere (2014), 454

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See detailApproche prothétique rationnelle et conservatrice d'usure dentaire avancée
Vanheusden, Alain ULg

in Revue d'Odonto-Stomatologie [=ROS] (2014), 43(3), 251-268

For several years, the number of young adults consulting for tooth tissue loss of non carious origin has been significantly increasing. However, many practitioners are still reluctant to treat these ... [more ▼]

For several years, the number of young adults consulting for tooth tissue loss of non carious origin has been significantly increasing. However, many practitioners are still reluctant to treat these lesions, especially when they are severe. Nevertheless, thanks to the constant improvement of the protocols of enamel and dentin bonding and a greater expertise in the field of prosthetic biomaterials, some rational, reliable and minimally invasive therapeutic approaches can often be proposed. The purpose of this article is to describe, stage by stage, a protocol of treatment based on bonded partial prosthetic restorations, both on anterior and posterior teeth. [less ▲]

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See detailLocal Stakeholders’ Perceptions About the Introduction of Performance-Based Financing in Benin: A Case Study in Two Health Districts
Paul, Elisabeth ULg; Sossouhounto, Nadine; Eclou, Dieudonné

in International Journal of Health Policy and Management (2014), 3

Background: Performance-Based Financing (PBF) has been advanced as a solution to contribute to improving the performance of health systems in developing countries. This is the case in Benin. This study ... [more ▼]

Background: Performance-Based Financing (PBF) has been advanced as a solution to contribute to improving the performance of health systems in developing countries. This is the case in Benin. This study aims to analyse how two PBF approaches, piloted in Benin, behave during implementation and what effects they produce, through investigating how local stakeholders perceive the introduction of PBF, how they adapt the different approaches during implementation, and the behavioural interactions induced by PBF. Methods: The research rests on a socio-anthropological approach and qualitative methods. The design is a case study in two health districts selected on purpose. The selection of health facilities was also done on purpose, until we reached saturation of information. Information was collected through observation and semi-directive interviews supported by an interview guide. Data was analysed through contents and discourse analysis. Results: The Ministry of Health (MoH) strongly supports PBF, but it is not well integrated with other ongoing reforms and processes. Field actors welcome PBF but still do not have a sense of ownership about it. The two PBF approaches differ notably as for the organs in charge of verification. Performance premiums are granted according to a limited number of quantitative indicators plus an extensive qualitative checklist. PBF matrices and verification missions come in addition to routine monitoring. Local stakeholders accommodate theoretical approaches. Globally, staff is satisfied with PBF and welcomes additional supervision and training. Health providers reckon that PBF forces them to depart from routine, to be more professional and to respect national norms. A major issue is the perceived unfairness in premium distribution. Even if health staff often refer to financial premiums, actually the latter are probably too weak — and ‘blurred’ — to have a lasting inciting effect. It rather seems that PBF motivates health workers through other elements of its ‘package’, especially formative supervisions. Conclusion: If the global picture is quite positive, several issues could jeopardise the success of PBF. It appears crucial to reduce the perceived unfairness in the system, notably through enhancing all facilities’ capacities to ensure they are in line with national norms, as well as to ensure financial and institutional sustainability of the system. [less ▲]

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See detailPropriétés physico-chimiques et biologiques des substances humiques en relation avec le développement végétal
Tahiri, Abdelghani ULg; Destain, Jacqueline ULg; Druart, Philippe et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(3), 436-445

Les substances humiques (SH) sont des composés organiques résultant de la transformation physique, chimique et microbiologique des résidus végétaux et animaux. Elles se retrouvent sous forme de ... [more ▼]

Les substances humiques (SH) sont des composés organiques résultant de la transformation physique, chimique et microbiologique des résidus végétaux et animaux. Elles se retrouvent sous forme de macromolécules carbonées hétérogènes et complexes dans tous les écosystèmes au niveau des sols ainsi que des sédiments, des eaux de surface et des lixiviats de décharges. Elles sont issues de processus d’humification déférents, générant ainsi des molécules variables et complexes composées principalement de carbone, d’hydrogène, d’oxygène, d’azote, de soufre et de groupements fonctionnels (COOH, OH, C=O). Ces substances sont connues pour influencer les propriétés du sol et interagir avec la croissance et le développement des plantes ou avec l’activité des microorganismes. L’influence de la croissance des plantes s’exprime généralement de manière directe via la stimulation des processus biochimiques et métaboliques ou indirecte via l’amélioration de la nutrition minérale. Mais, l’intensité de réponse reste dépendante de différents paramètres tels que l’origine, la nature de la matière organique initiale, les processus de transformation et la concentration des SH ainsi que des conditions expérimentales et des plantes traitées. Les mécanismes par lesquels les SH exercent leurs effets favorables sur les végétaux sont imprécis et généralement pas bien compris. [less ▲]

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See detailBiointerface multiparametric investigation of intraocular lens acrylic materials
Bertrand, Virginie ULg; Bozukova, Dimitriya; Svaldo Lanero, Tiziana et al

in Journal of Cataract & Refractive Surgery (2014), 40(9), 1536-1544

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See detailSynthesis, Surface characterization and photocatalytic activity of TiO2 supported on almond shell activated carbon
Omri, Abdessalem; Lambert, Stéphanie ULg; Geens, Jérémy ULg et al

in Journal of Materials Science & Technology (2014), 30(9), 894-902

Three types of photocatalysts were synthesized by metal organic chemical vapor deposition and impregnation methods using the almond shell activated carbon as support. These photocatalysts denoted by (TiO2 ... [more ▼]

Three types of photocatalysts were synthesized by metal organic chemical vapor deposition and impregnation methods using the almond shell activated carbon as support. These photocatalysts denoted by (TiO2/ASAC (V), TiO2/ASAC (I1) and TiO2/ASAC (I2)) were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), diffuse reflectance spectroscopy (DRS) and nitrogen adsorptionedesorption isotherms. SEM observation shows that TiO2 was deposited on activated carbon surface. XRD results confirm that TiO2 existed in a mixture of anatase and rutile phases. The DRS spectra show the characteristic absorption edge of TiO2 at approximate 380 nm corresponding to the optical band gap of 3.26 eV. Besides, FTIR spectrum indicated the presence of (TieO) groups. The specific surface area of photocatalysts decreased drastically in comparison with the original activated carbon. The catalysts were very efficient for the photodegradation of total organic carbon (TOC) from industrial phosphoric acid solution under UV irradiation. The kinetics of photocatalytic TOC degradation was found to follow a pseudofirst- order model. The prepared TiO2/ASAC showed high photoactivity for the photodegradation of TOC in the following order: TiO2/ASAC (V) > TiO2/ASAC (I1) > TiO2/ASAC (I2) > ASAC > TiO2 (P25). [less ▲]

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See detailA Geometrical Acoustics Approach Linking Surface Scattering and Reverberation in Room Acoustics
Embrechts, Jean-Jacques ULg

in Acta Acustica United with Acustica (2014), 100(5), 864-879

A general model of the influence of surface scattering on the reverberation time would have several applications in room acoustics. Such a model is not yet available, and it is the purpose of this paper ... [more ▼]

A general model of the influence of surface scattering on the reverberation time would have several applications in room acoustics. Such a model is not yet available, and it is the purpose of this paper to investigate a geometrical acoustics approach. Starting from the radiative transfer equation, an exponential solution is first developed for the reverberation energy decay in rooms with diffusely reflecting boundaries. Differences with the diffuse sound field (Sabine) theory are highlighted, leading to a modified formula for the reverberation time which is shown to be more in accordance with ray tracing simulations. A general model is then proposed for rooms in which specular and diffuse reflections coexist. This general model is applied in rooms where the specular contribution can be assumed to be quasi-isotropic and uniform. Under this assumption, the reverberation decay is represented by the sum of two exponential functions, depending on the scattering coefficients. However, it is shown that the influence of surfaces’ scattering on reverberation is rather limited in this case. On the contrary, rooms with a pair of parallel surfaces are prone to create significant anisotropy in the cloud of image sources. An analytical formulation is proposed in this case for the specular and diffuse contributions, provided that some assumptions are again made on the specularly reflected sound field. The final expression is not really intuitive concerning the relation between scattering coefficients and reverberation, but it contains all the variables influencing this relation. This allows fast evaluations of the effect of surface scattering in particular situations. Finally, the application of this model to room acoustics computer simulations is illustrated by an example. [less ▲]

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See detailComentário sobre o artigo de Pizzanelli
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2014), 9(31),

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See detailThe puzzling new class of variable stars in NGC 3766 : old friend pulsators?
Salmon, Sébastien ULg; Montalban Iglesias, Josefa ULg; Reese, Daniel et al

in Astronomy and Astrophysics (2014), 569

The recent variability survey of the NGC 3766 cluster revealed a considerable number of periodic variable stars in a region of the H-R diagram where no pulsation is expected. This region lies between the ... [more ▼]

The recent variability survey of the NGC 3766 cluster revealed a considerable number of periodic variable stars in a region of the H-R diagram where no pulsation is expected. This region lies between the instability strips of the delta Scuti and SPB stars. Moreover the periods of the new phenomenon, P~0.1-0.7 d, do not allow to associate it a priori to either of these two types of pulsations. Stars in the NGC 3766 cluster are known as fast rotators with rotational velocities typically larger than half of their critical velocity. Rotation can affect both the geometrical properties and period domain of pulsations. It also alters the apparent stellar luminosity through gravity darkening, effect seldom taken considered in theoretical studies of the rotation-pulsation interaction. We explore if both of these effects are able to deliver a consistent interpretation for the observed properties of the "new variables" in NGC 3766: explaining their presence outside the known instability strips and their variability periods. We carry out an instability analysis of SPB models within the framework of the Traditional Approximation of Rotation and study the visibility of modes according to the angle of view and rotation. We also check how gravity darkening affects the effective temperature and luminosity of stellar models for different angles of view and rotation velocities. At the red (cold) border of the instability strip, prograde sectoral modes are preferentially excited and their visibilities are maximum when seen equator-on. Furthermore low-mass SPB models seen equator-on can appear in the gap between non-rotating SPB and delta Scuti stars due to gravity darkening. In that case, periods of these most visible modes are shifted to the 0.2-0.5 d range due to the effects of the Coriolis force. We hence suggest that the new variable stars observed in NGC 3766 are actually fast rotating SPB pulsators. [less ▲]

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See detailMultilocus sequence typing analysis and antibiotic resistance of Clostridium difficile strains isolated from retail meat and humans in Belgium
Rodriguez Diaz, Cristina ULg; Taminiau, Bernard ULg; Avesani, Véronique et al

in Food Microbiology (2014), 42

Clostridium difficile has been isolated from food animals and meat, specially ground pork and ground beef. The recovered isolates were closely related to C. difficile human strains, indicating that ... [more ▼]

Clostridium difficile has been isolated from food animals and meat, specially ground pork and ground beef. The recovered isolates were closely related to C. difficile human strains, indicating that animals and food are possible transmission routes of human C. difficile infection. The main objective of this study was to characterize C. difficile isolates from retail meat and to compare with human isolates recovered from hospital patients in Belgium. Raw meat (beef and pork) was obtained from the retail trade. C. difficile was recovered from 2.3% of the beef samples and from 4.7% of the pork samples. A total of 4 different PCR-ribotypes were identified with a large percentage of types 078 and 014. Resistance to moxifloxacin and erythromycin was detected. The multi-locus sequence typing (MLST) analysis showed that meat and human isolates cluster in the same lineage. This study reveals the presence of toxigenic C. difficile in retail meat in Belgium with predominance PCR-ribotypes 078 and 014, which are among the four most prevalent ribotypes of C. difficile isolated from humans in Europe. [less ▲]

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