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See detailRisks for All-Cause Mortality: Stratified by Age, Estimated Glomerular Filtration Rate and Albuminuria.
Warnock, DG; DELANAYE, Pierre ULiege; Glassock, RJ

in Nephron (2017), 136(4), 292-297

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See detailA water retention model for compacted bentonites
Dieudonné, Anne-Catherine ULiege; Della Vecchia, Gabriele; Charlier, Robert ULiege

in Canadian Geotechnical Journal (2017)

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See detailA French version of the Balanced Time Perspective Scale: Factor structure and relation to cognitive reappraisal.
Barsics, Catherine ULiege; Rebetez, Marie; Rochat, Lucien et al

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2017), 49(1), 51-57

A frequent and equal tendency to think positively about one’s past and future has been conceptualised as a balanced time perspective (TP). Such a dispositional temporal orientation has been associated ... [more ▼]

A frequent and equal tendency to think positively about one’s past and future has been conceptualised as a balanced time perspective (TP). Such a dispositional temporal orientation has been associated with higher life satisfaction and happiness. The aim of the present study was to develop and to validate a French version of the Balanced Time Perspective Scale (BTPS; Webster, 2011), which has been specifically designed to assess the combined use of positive future and past mental representations as resources for the self. Data were collected from an online survey in a sample of 622 French-speaking individuals from the general population. Results indicated that the French version of the BTPS replicated the 2-factor structure of the original questionnaire, and showed excellent internal consistency. External validity was supported by specific rela- tionships with measures of TP and positive affect. In addition, a high propensity to project oneself positively both in the future and the past was associated with greater use of cognitive reappraisal. [less ▲]

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See detailEvaluation d'un itinéraire clinique pour collectomie gauche en chirurgie abdominale
Mattart, Laurine; Stevens, Marie; Magis, David ULiege et al

in Revue Médicale de Liège (2017), 72(1), 45-50

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne ... [more ▼]

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne nécessitant une résection du côlon gauche par laparoscopie a été incluse dans cet IC entre 2009 et 2015. Nous nous sommes intéressés à l’observance du protocole de l’IC ainsi qu’aux taux de complications et de ré-hospitalisations dans les 30 jours post-opératoires. Nous avons constaté, après comparaison avec un groupe témoin historique, que l’adhésion au protocole IC a été d’emblée excellente (> 80 %) tout au long de la durée de l’étude. Il n’y a pas eu de modification du taux de ré-hospitalisations et le taux de lâchage de suture a été réduit. Bien que la diminution de la durée de séjour n’était pas l’objectif premier lors de la mise en place de cet IC, elle s’est significativement réduite passant, en moyenne, de 8 à 4 jours. En conclusion, l’introduction d’un IC, pour autant qu’il soit bien préparé et rassemble dans le même objectif l’ensemble des acteurs de soins, est directement bénéfique pour le patient et la qualité de sa prise en charge. [less ▲]

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See detailOrganic Farming and Small-Scale Farmers: Main Opportunities and Challenges
Jouzi, Zeynab; Azadi, Hossein ULiege; Taheri, Fatemeh et al

in Ecological Economics (2017), 132(February 2017), 144-154

Producing enough food to meet the needs of a growing population has always been the greatest concern of food policy-makers around the world. Given the increasing attention to organic farming (OF), we ... [more ▼]

Producing enough food to meet the needs of a growing population has always been the greatest concern of food policy-makers around the world. Given the increasing attention to organic farming (OF), we conducted this study to investigate the main opportunities and challenges of the food production system of small-scale farmers in developing countries with an emphasis on their livelihoods. The study showed that the most significant advantages of OF are environmental protection and a higher resilience to environmental changes, increasing farmers' income and reducing external input cost, enhancing social capacity and increasing employment opportunities. A s well as enhancing food security primarily by increasing the food purchasing power of local people. However, the main challenges of this food production system include lower yields in comparison to conventional systems, difficulties with soil nutrient management, certification and market barriers, and the educational and research needs of small-holders. The paper concludes that even though OF might present some significant challenges to small-scale farmers, it could/should still be considered as a part of the solution and means of improving their livelihoods. [less ▲]

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See detailTopography and Lateralized Effect of Acute Aromatase Inhibition on Auditory Processing in a Seasonal Songbird
de groof, Geert; Balthazart, Jacques ULiege; Cornil, Charlotte ULiege et al

in Journal of Neuroscience (2017), 37(16), 4243-4254

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of ... [more ▼]

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of estrogens on nuclear receptors. One of the best examples of such neuro- modulation by neuroestrogens concerns the acute regulation of sensory coding by the auditory cortex as demonstrated by electrophys- iological studies of selected neurons in zebra finches. Yet, the spatial extent of such modulation by neuroestrogens is not known. Using functional magnetic resonance imaging, we demonstrate here that acute estrogen depletion alters within minutes auditory processing in male European starlings. These effects are confined to very specific but large areas of the auditory cortex. They are also specifically lateralized to the left hemisphere. Interestingly, the modulation of auditory responses by estrogens was much larger (both in amplitude and in topography) in March than in December or May/June. This effect was presumably independent from changes in circulating testosterone concentrations since levels of the steroid were controlled by subcutaneous implants, thus suggesting actions related to other aspects of the seasonal cycle or photoperiodic manipulations. Finally, we also show that estrogen production specifically modulates selectivity for behaviorally relevant vocalizations in a specific part of the caudomedial nidopallium. These findings confirm and extend previous conclusions that had been obtained by electrophysiological techniques. This approach provides a new very powerful tool to investigate auditory responsiveness in songbirds and its fast modulation by sex steroids. [less ▲]

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See detailPoor Performance of a Retrofitted Downstream Bypass Revealed by the Analysis of Approaching Behaviour in Combination with a Trapping System
Ovidio, Michaël ULiege; Dierckx, Arnaud ULiege; Bunel, Sarah et al

in River Research & Applications (2017), 33

The implementation of fish downstream migration bypass systems is still a major challenge, and there is interest in validating the adequacy of different configurations of bypass devices. In the Amblève ... [more ▼]

The implementation of fish downstream migration bypass systems is still a major challenge, and there is interest in validating the adequacy of different configurations of bypass devices. In the Amblève River (Belgium), a mobile 3.3-m height dam feeds two principal Francis and one Francis micro-turbine and is equipped with a modern vertical slot fish pass and a downstream bypass. The aim of this study was to test the bypass attraction and efficiency (i.e. percentage of fish that approach the entrance and use the bypass) for Atlantic salmon smolts. During three consecutive years, a total of 1346 smolts were equipped with a radio frequency identification tag and released from March to May upstream of the dam of Lorcé. The entrance of the downstream migration bypass was equipped with a radio frequency identification antenna in order to detect the smolts approaching. In 2014, a capture cage was also placed downstream the bypass to evaluate its efficiency. The mean percentage of detected smolts at the entrance varied from 26.2 to 39.7%. In 2014, 16.5% of the released smolts entered the bypass and were finally caught in the cage, representing 39% of the smolts detected at the entrance. More than 98% of the detections occurred during night (mainly between 9 PM and 3 AM). The searching delay near the bypass entrance varied from less than 5 min to more than 5 days (median 4.3 min). Visual observation indicated a behavioural reluctance before entering the bypass, with a shift from positive to negative rheotaxy. Our results underline the difficulty to install retrofitted bypass system on old existing hydropower plants. Copyright © 2016 John Wiley & Sons, Ltd. [less ▲]

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See detailQue peut la doctrine en droit des sociétés (et ailleurs)?
Thirion, Nicolas ULiege

in Revue Pratique des Sociétés - Tijdschrift voor Rechtspersoon en Vennootschap (2017), 1

A quelle condition la doctrine peut-elle relever d'une démarche proprement scientifique? Telle est la question qu'abord cet éditorial.

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See detailPolyurethane coatings in 20th century outdoor painted sculptures. Part II: Comparative study of four systems by means of Py-GC/MS
Defeyt, Catherine ULiege; Schilling, Michael; Langenbacher, Julia et al

in Heritage Science (2017), 5(15),

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to ... [more ▼]

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to coat sculptures intended for an outdoor setting. However, the PU class includes various systems, such as two package solvent-borne, two package water-borne, one package water-borne and fluoropolymer polyurethanes, which possess very different properties. 115 reference samples of PU coatings were investigated by means of Py-GC/MS, in order to outline the differences and the similarities existing, in terms of composition, between the major PU systems used for creating as well as for conserving modern painted outdoor sculptures. The Py- GC/MS study of an extended number of reference samples showed that the composition of equivalent PU systems strongly varies depending on the product line and the manufacturer. Furthermore the comparison of all the produced pyrograms allowed defining characteristic marker compounds helpful to discriminate specific PU paint systems. [less ▲]

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See detailDermatophytes and Dermatophytoses: A Thematic Overview of State of the Art, and the Directions for Future Research and Developments
Bouchara, JP; Mignon, Bernard ULiege; Chaturvedi, V

in Mycopathologia (2017), 182(1), 1-4

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See detailResponsible research and innovation as a travesty of technology assessment?
Delvenne, Pierre ULiege

in Journal of Responsible Innovation (2017)

The relation between technology assessment (TA) and responsible research and innovation (RRI) is a very topical (and controversial) issue, as TA is clearly enveloped in broader science, technology and ... [more ▼]

The relation between technology assessment (TA) and responsible research and innovation (RRI) is a very topical (and controversial) issue, as TA is clearly enveloped in broader science, technology and innovation (STI) processes, such as the EU-wide shift towards RRI. In this short response to van Lente et al.’s [Van Lente, Harro, Tsjalling Swierstra, and Pierre-Benoit̂ Joly. 2017. “Responsible Innovation as a Critique of Technology Assessment.” Journal of Responsible Innovation] essay, I first stress that this contribution has several merits; for example, it points to pervasive challenges for TA communities, such as the issue of including normative concerns when assessing innovations, it opens these challenges to debate, without shying away from engaging TA communities. However, I disagree with the authors’ claim that RRI would be ‘a next step of TA’ or even a ‘form of TA’. In my essay, I explain why I believe RRI is different from TA and why, rather than a critique of TA, RRI could instead lead to a travesty of TA, threatening the vitality and the uniqueness of TA institutions in the long-term. Under the spell of RRI, TA risks being reduced to a role of mere provider of ex-ante impact assessments. I conclude that following the money attached to RRI has a price that TA institutions should carefully, critically and reflexively consider before they pay. [less ▲]

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See detailInfluence of corn variety, drying temperature and moisture content at harvest on the saccharides released during an in vitro pepsin-pancreatin digestion
Odjo, Sylvanus; Huart, François ULiege; Bera, François ULiege et al

in Starch-Stärke (2017)

High-Performance Anion-Exchange Chromatography Coupled with Pulsed Amperometric Detection (HPAEC-PAD) was used to quantify and to determine the nature of saccharides released after the digestion of two ... [more ▼]

High-Performance Anion-Exchange Chromatography Coupled with Pulsed Amperometric Detection (HPAEC-PAD) was used to quantify and to determine the nature of saccharides released after the digestion of two corn grains submitted to different drying and harvesting protocols. Five saccharides were quantified: glucose, maltose, isomaltose, maltotriose and glucosyl-maltotriose. After a subsequent hydrolysis with amyloglucosidase of the released sugar, the amount of total glucose recovered increased with the increase in drying temperature and the moisture content of grain at harvest. These results suggest that structural changes induced within corn starch granules during drying affect their hydrolysis by amylases. These changes may lead to different pathways of sugar absorption in the small intestine of monogastrics. Thus, corn grains with a similar composition may lead to different levels of metabolizable energy upon gastro-intestinal digestion. [less ▲]

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See detailLe colloque Francarbi à Bruxelles : le principe du contradictoire en arbitrage
Caprasse, Olivier ULiege

in Journal des Tribunaux (2017)

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See detailPossible survivorship bias rather than reverse causality in EMPA-REG OUTCOME.
Scheen, André ULiege

in Diabetes Research & Clinical Practice (2017), (May),

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See detailSedation of Patients With Disorders of Consciousness During Neuroimaging: Effects on Resting State Functional Brain Connectivity.
KIRSCH, Murielle ULiege; Guldenmund, Pieter; Bahri, Mohamed Ali ULiege et al

in Anesthesia and Analgesia (2017), 124(2),

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See detailResponse of Jupiter's auroras to conditions in the interplanetary medium as measured by the Hubble Space Telescope and Juno
Nichols, J. D.; Badman, S. V.; Bagenal, F. et al

in Geophysical Research Letters (2017)

We present the first comparison of Jupiter's auroral morphology with an extended, continuous and complete set of near-Jupiter interplanetary data, revealing the response of Jupiter's auroras to the ... [more ▼]

We present the first comparison of Jupiter's auroral morphology with an extended, continuous and complete set of near-Jupiter interplanetary data, revealing the response of Jupiter's auroras to the interplanetary conditions. We show that for ∼1-3 days following compression region onset the planet's main emission brightened. A duskside poleward region also brightened during compressions, as well as during shallow rarefaction conditions at the start of the program. The power emitted from the noon active region did not exhibit dependence on any interplanetary parameter, though the morphology typically differed between rarefactions and compressions. The auroras equatorward of the main emission brightened over ∼10 days following an interval of increased volcanic activity on Io. These results show that the dependence of Jupiter's magnetosphere and auroras on the interplanetary conditions are more diverse than previously thought. [less ▲]

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See detailCopper adsorption from wasterwater using bone charcoal
Ghrab, Sana; Benzina, Mourad; Lambert, Stéphanie ULiege

in Advances in Materials Physics and Chemistry (2017), 7

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See detailReconsidering Prenatal Hormonal Influences on Human Sexual Orientation: Lessons from Animal Research.
Baum, Michael J.; Bakker, Julie ULiege

in Archives of Sexual Behavior (2017)

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See detailCXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone.
Goffart, Nicolas ULiege; Lombard, Arnaud; Lallemand, François ULiege et al

in Neuro-Oncology (2017), 19(1), 66-77

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that ... [more ▼]

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that might arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated that GSCs are able to escape the tumor mass and preferentially colonize the adult subventricular zone (SVZ). At a distance from the initial tumor site, these GSCs might therefore represent a high-quality model of clinical resilience to therapy and cancer relapses as they specifically retain tumor-initiating abilities. METHOD: While relying on recent findings that have validated the existence of GSCs in the human SVZ, we questioned the role of the SVZ niche as a potential GSC reservoir involved in therapeutic failure. RESULTS: Our results demonstrate that (i) GSCs located in the SVZ are specifically resistant to radiation in vivo, (ii) these cells display enhanced mesenchymal roots that are known to be associated with cancer radioresistance, (iii) these mesenchymal traits are specifically upregulated by CXCL12 (stromal cell-derived factor-1) both in vitro and in the SVZ environment, (iv) the amount of SVZ-released CXCL12 mediates GBM resistance to radiation in vitro, and (v) interferes with the CXCL12/CXCR4 signalling system, allowing weakening of the tumor mesenchymal roots and radiosensitizing SVZ-nested GBM cells. CONCLUSION: Together, these data provide evidence on how the adult SVZ environment, through the release of CXCL12, supports GBM therapeutic failure and potential tumor relapse. [less ▲]

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See detailAnalogical reasoning in children with specific language impairment: Evidence from a scene analogy task
Krzemien, Magali ULiege; Jemel, Boutheina; Maillart, Christelle ULiege

in Clinical Linguistics & Phonetics (2017)

Analogical reasoning is a human ability that maps systems of relations. It develops along with relational knowledge, working memory and executive functions such as inhibition. It also maintains a mutual ... [more ▼]

Analogical reasoning is a human ability that maps systems of relations. It develops along with relational knowledge, working memory and executive functions such as inhibition. It also maintains a mutual influence on language development. Some authors have taken a greater interest in the analogical reasoning ability of children with language disorders, specifically those with specific language impairment (SLI). These children apparently have weaker analogical reasoning abilities than their aged-matched peers without language disorders. Following cognitive theories of language acquisition, this deficit could be one of the causes of language disorders in SLI, especially those concerning productivity. To confirm this deficit and its link to language disorders, we use a scene analogy task to evaluate the analogical performance of SLI children and compare them to controls of the same age and linguistic abilities. Results show that children with SLI perform worse than age-matched peers, but similar to language-matched peers. They are more influenced by increased task difficulty. The association between language disorders and analogical reasoning in SLI can be confirmed. The hypothesis of limited processing capacity in SLI is also being considered. [less ▲]

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See detailCanagliflozin: A Review in Type 2 Diabetes.
Deeks, Emma D.; Scheen, André ULiege

in Drugs (2017)

Canagliflozin (Invokana(R)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D). Canagliflozin lowers ... [more ▼]

Canagliflozin (Invokana(R)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D). Canagliflozin lowers blood glucose levels independently of insulin, with the inhibition of SGLT2 reducing renal reabsorption of glucose and increasing excretion of glucose in the urine. In well-designed clinical trials, canagliflozin (as first-line monotherapy or add-on therapy to other antihyperglycaemic agents) improved glycaemic control in adults with T2D, including those of older age and/or at high cardiovascular (CV) risk, and also had beneficial effects on their bodyweight and blood pressure (BP). CV risk reduction, as well as possible renal benefits, were also seen with canagliflozin in T2D patients at high CV risk in the CANVAS Program, an integrated analysis of two large CV outcomes studies. Canagliflozin was generally well tolerated, had a low risk of hypoglycaemia and was most commonly associated with adverse events such as genital and urinary tract infections and increased urination, consistent with its mechanism of action. Although the amputation and fracture risk observed among recipients of the drug require further investigation, canagliflozin is an important option for T2D management in adults. [less ▲]

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See detailEvaluation of the long-term effect of biochar on properties of temperate agricultural soil at pre-industrial charcoal kiln sites in Wallonia, Belgium
Hardy, Brieuc; Cornelis, Jean-Thomas ULiege; Houben, David et al

in European Journal of Soil Science (2017), 68

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See detailExploring sex differences in the adult zebra finch brain: in vivo diffusion tensor imaging and ex vivo super-resolution track density imaging
Hamaide, J.; De Groof, G.; Van Steenkiste, G. et al

in NeuroImage (2017), 146

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural ... [more ▼]

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural investigation of the zebra finch brain has been performed ex vivo using invasive methods such as histology. These methods are highly specific, however, they strongly interfere with performing whole-brain analyses and exclude longitudinal studies aimed at establishing causal correlations between neuroplastic events and specific behavioral performances. Therefore, the aim of the current study was to implement an in vivo Diffusion Tensor Imaging (DTI) protocol sensitive enough to detect structural sex differences in the adult zebra finch brain. Voxel-wise comparison of male and female DTI parameter maps shows clear differences in several components of the song control system (i.e. Area X surroundings, the high vocal center (HVC) and the lateral magnocellular nucleus of the anterior nidopallium (LMAN)), which corroborate previous findings and are in line with the clear behavioral difference as only males sing. Furthermore, to obtain additional insights into the 3-dimensional organization of the zebra finch brain and clarify findings obtained by the in vivo study, ex vivo DTI data of the male and female brain were acquired as well, using a recently established super-resolution reconstruction (SRR) imaging strategy. Interestingly, the SRR-DTI approach led to a marked reduction in acquisition time without interfering with the (spatial and angular) resolution and SNR which enabled to acquire a data set characterized by a 78μm isotropic resolution including 90 diffusion gradient directions within 44h of scanning time. Based on the reconstructed SRR-DTI maps, whole brain probabilistic Track Density Imaging (TDI) was performed for the purpose of super resolved track density imaging, further pushing the resolution up to 40μm isotropic. The DTI and TDI maps realized atlas-quality anatomical maps that enable a clear delineation of most components of the song control and auditory systems. In conclusion, this study paves the way for longitudinal in vivo and high-resolution ex vivo experiments aimed at disentangling [less ▲]

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See detailTracking Invasive Alien Species (TrIAS): Building a data-driven framework to inform policy
Vanderhoeven, Sonia; Adriaens, Tim; Desmet, Peter et al

in Research Ideas and Outcomes (2017), 3

Imagine a future where dynamically, from year to year, we can track the progression of alien species (AS), identify emerging problem species, assess their current and future risk and timely inform policy ... [more ▼]

Imagine a future where dynamically, from year to year, we can track the progression of alien species (AS), identify emerging problem species, assess their current and future risk and timely inform policy in a seamless data-driven workflow. One that is built on open science and open data infrastructures. By using international biodiversity standards and facilities, we would ensure interoperability, repeatability and sustainability. This would make the process adaptable to future requirements in an evolving AS policy landscape both locally and internationally. In recent years, Belgium has developed decision support tools to inform invasive alien species (IAS) policy, including information systems, early warning initiatives and risk assessment protocols. However, the current workflows from biodiversity observations to IAS science and policy are slow, not easily repeatable, and their scope is often taxonomically, spatially and temporally limited. This is mainly caused by the diversity of actors involved and the closed, fragmented nature of the sources of these biodiversity data, which leads to considerable knowledge gaps for IAS research and policy. We will leverage expertise and knowledge from nine former and current BELSPO projects and initiatives: Alien Alert, Invaxen, Diars, INPLANBEL, Alien Impact, Ensis, CORDEX.be, Speedy and the Belgian Biodiversity Platform. The project will be built on two components: 1) The establishment of a data mobilization framework for AS data from diverse data sources and 2) the development of data-driven procedures for risk evaluation based on risk modelling, risk mapping and risk assessment. We will use facilities from the Global Biodiversity Information Facility (GBIF), standards from the Biodiversity Information Standards organization (TDWG) and expertise from Lifewatch to create and facilitate a systematic workflow. Alien species data will be gathered from a large set of regional, national and international initiatives, including citizen science with a wide taxonomic scope from marine, terrestrial and freshwater environments. Observation data will be funnelled in repeatable ways to GBIF. In parallel, a Belgian checklist of AS will be established, benefiting from various taxonomic and project-based checklists foreseen for GBIF publication. The combination of the observation data and the checklist will feed indicators for the identification of emerging species; their level of invasion in Belgium; changes in their invasion status and the identification of areas and species of concern that could be impacted upon by bioinvasions. Data-driven risk evaluation of identified emerging species will be supported by niche and climate modelling and consequent risk mapping using critical climatic variables for the current and projected future climate periods at high resolution. The resulting risk maps will complement risk assessments performed with the recently developed Harmonia+ protocol to assess risks posed by emergent species to biodiversity and human, plant, and animal health. The use of open data will ensure that interested stakeholders in Belgium and abroad can make use of the information we generate. The open science ensures everyone is free to adopt and adapt the workflow for different scenarios and regions. The checklist will be used at national level, but will also serve as the Belgian reference for international databases (IUCN - GRIIS, EASIN) and impact assessments (IPBES, SEBI). The workflow will be showcased through GEO BON, the Invasivesnet network and the COST Actions Alien Challenge and ParrotNet. The observations and outcomes of risk evaluations will be used to provide science-based support for the implementation of IAS policies at the regional, federal and EU levels. The publication of Belgian data and checklists on IAS is particularly timely in light of the currently ongoing EU IAS Regulation and its implementation in Belgium. By proving that automated workflows can provide rapid and repeatable production of information, we will open up this technology for other conservation assessments. [less ▲]

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See detailReconstitution of adaptive immunity after umbilical cord blood transplantation and clinical implication regarding risk of infections
SERVAIS, Sophie ULiege; Hannon, Muriel ULiege; Peffault de Latour, R. et al

in Stem Cell Invest. (2017), 4

In comparison with allogeneic stem cell transplantation (alloHSCT) with other stem cell sources, umbilical cord blood transplantation (UCBT) was traditionally associated with increased risk of infections ... [more ▼]

In comparison with allogeneic stem cell transplantation (alloHSCT) with other stem cell sources, umbilical cord blood transplantation (UCBT) was traditionally associated with increased risk of infections, particularly during the first 3 months after transplantation. Longitudinal studies of immune monitoring reported peculiar patterns of T- and B-cell recovery in the peripheral blood of UCB recipients during the first months post-transplantation. Overall, current data suggest delayed reconstitution of naive and memory CD4+ and CD8+ T-cell pools after UCBT. This is particularly true for adult recipients and for patients who received in vivo T-cell depleting approaches before the transplantation. Such delayed T-cell recovery may increase susceptibility of UCB recipients for developing opportunistic infections and viral reactivations. Regarding B-cell recovery, UCBT was associated with accelerated B-lymphopoiesis. Recent studies also reported evidence for faster functional memory B-cell recovery in UCB recipients. In this article, we briefly review T- and B-cell reconstitution after alloHSCT, with emphasis on peculiarities observed after UCBT. We further put these data in lines with risks of infections after UCBT. [less ▲]

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See detailAre Th17 Cells Playing a Role in Immunity to Dermatophytosis?
Heinen, Marie-Pierre ULiege; Cambier, Ludivine ULiege; Fievez, Laurence ULiege et al

in Mycopathologia (2017), 182(1), 251-261

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See detailRelevance of adding a triangular dynamic cushion on a traditional chair: A 3D-analysis of seated schoolchildren
Fettweis, Tatiana ULiege; Onkelinx, Marie-Noëlle; Schwartz, Cédric ULiege et al

in Clinical Biomechanics (2017)

Background: Low back pain is highly prevalent in the general population and is even reported as early as at primary school. A poor sitting position has been suggested as an etiologic factor. This study ... [more ▼]

Background: Low back pain is highly prevalent in the general population and is even reported as early as at primary school. A poor sitting position has been suggested as an etiologic factor. This study analysed, in primary schoolchildren, the influence of a triangular dynamic cushion that aims to help children maintain their physiological lumbar lordosis and to induce movement to reduce the static effect of the sitting position. Methods: Thirty 8-year-old children took part in this study. A 3D analysis combined with electromyography was used to evaluate the biomechanics and the related muscle activation in two sitting positions (with and without a triangular cushion on a horizontal stool) during a 15-minute working task. In addition, the force of the feet on the ground was assessed with a force plate. Findings: The cushion improved the trunk–thighs angle, lumbar lordosis, anterior pelvis tilt, and feet support on the ground (p < 0.0001). In addition, sitting on the cushion appeared to be more dynamic (p < 0.05) and induced a decrease of the lumbar paravertebral muscle activity (p < 0.01). Interpretation: Sitting on a dynamic triangular cushion tends to favour the “ideal” siting position usually described in the literature and to decrease the level of paravertebral muscle recruitment. Seeing that sitting position is a risk factor to develop low back pain, the cushion could be a solution to prevent it. [less ▲]

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See detailManagement of abdominal wall desmoid tumors.
DETRY, Olivier ULiege

in Acta Chirurgica Belgica (2017)

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See detailDesign sensitivity analysis for shape optimization based on the Lie derivative
Kuci, Erin ULiege; Henrotte, François ULiege; Duysinx, Pierre ULiege et al

in Computer Methods in Applied Mechanics & Engineering (2017)

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed ... [more ▼]

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed from differential geometry, shows that sensitivity of a performance function (i.e. any function of the solution of the problem) with respect to a given design variable can be represented mathematically as a Lie derivative, i.e. the derivative of that performance function along a flow representing the continuous shape modification of the geometrical model induced by the variation of the considered design variable. Theoretical formulae to express sensitivity analytically are demonstrated in detail in the paper, and applied to a nonlinear magnetostatic and a linear elastic problem, following both the direct and the adjoint approaches. Following the analytical approach, one linear system of which only the right-hand side needs be evaluated (the system matrix being known already) has to be solved for each of the design variables in the direct approach, or for each performance functions in the adjoint approach. A substantial gain in computation time is obtained this way compared to a finite difference evaluation of sensitivity, which requires solving a second nonlinear system for each design variable. This is the main motivation of the analytical approach. There is some freedom in the definition of the auxiliary flow that represents the shape modification. We present a method that makes benefit of this freedom to express sensitivity locally as a volume integral over a single layer of finite elements connected to both sides of the surfaces undergoing shape modification. All sensitivity calculations are checked with a finite difference in order to validate the analytic approach. Convergence is analyzed in 2D and 3D, with first and second order finite elements. [less ▲]

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See detailEquivalent to Represent Inertial and Primary Frequency Control Effects of an External System
Weckesser, Johannes ULiege; Van Cutsem, Thierry ULiege

in IET Generation, Transmission & Distribution (2017)

This paper presents a novel equivalent, which is suitable for simulation of inertial and primary frequency control effects. In the model reduction procedure, dynamic power injectors are used to replace ... [more ▼]

This paper presents a novel equivalent, which is suitable for simulation of inertial and primary frequency control effects. In the model reduction procedure, dynamic power injectors are used to replace the external system and to mimic its dynamic behavior. The parameters of the equivalents are tuned with a simple approach presented in this paper. The effectiveness of the proposed method is demonstrated on a modified version of the ENTSO-E Dynamic Study Model. The results show that the system frequency response of the unreduced system is retained and a speedup of the simulations of around 4.0 is achieved. [less ▲]

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See detailLa gestion de la matière organique du sol, un enjeu important pour limiter la lixiviation du nitrate vers les eaux souterraines
Vandenberghe, Christophe ULiege; Colinet, Gilles ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21

Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive ... [more ▼]

Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive (ND). This vulnerable area has a relatively high diversity of agro-soil environments. Thus, the nitrogen content of agricultural soils can vary locally by a factor 4. Objectives. This study aimed to establish whether the carbon content of a soil is a significant risk factor in nitrate leaching to groundwater. Method. The article is based on measurements of nitrate nitrogen residue (APL) and soil total organic carbon (TOC) at the beginning of the leaching period. The measurements were made in 2012 in 1,500 plots, during inspections organized by the Wallonia Public Service. This was as part of the application of the Program for the Sustainable Management of Nitrogen in Agriculture, the scheme for implementing the ND within the Walloon region. Results. Examination of the results showed both that the APL was positively correlated to the TOC and that plots with “noncompliant” APL results had a significantly higher average TOC than the other plots. Conclusions. Since APL is an environmental indicator of the risk of nitrate leaching, it appears that the TOC may constitute a risk of groundwater contamination by nitrate. It is therefore advisable to improve the inclusion of this parameter in advice regarding nitrogen fertilization and secondly, in the case of summer harvest, to better manage the sowing of catch crops. [less ▲]

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See detailProbabilistic Framework for the Characterization of Surfaces and Edges in Range Images, with Application to Edge Detection
Lejeune, Antoine ULiege; Verly, Jacques ULiege; Van Droogenbroeck, Marc ULiege

in IEEE Transactions on Pattern Analysis & Machine Intelligence (2017)

We develop a powerful probabilistic framework for the local characterization of surfaces and edges in range images, which is useful in many applications of computer vision, such as filtering, edge ... [more ▼]

We develop a powerful probabilistic framework for the local characterization of surfaces and edges in range images, which is useful in many applications of computer vision, such as filtering, edge detection, feature extraction, and classification. We use the geometrical nature of the data to derive an analytic expression for the joint probability density function (pdf) for the random variables used to model the ranges of a set of pixels in a local neighborhood of an image. We decompose this joint pdf by considering independently the cases where two real world points corresponding to two neighboring pixels are locally on the same real world surface or not. In particular, we show that this joint pdf is linked to the Voigt pdf and not to the Gaussian pdf as it is assumed in some applications. We apply our framework to edge detection and develop a locally adaptive algorithm that is based on a probabilistic decision rule. We show in an objective evaluation that this new edge detector performs better than prior art edge detectors. This proves the benefits of the probabilistic characterization of the local neighborhood as a tool to improve applications that involve range images. [less ▲]

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See detailExploring the links between community-based governance and sustainable energy use: Quantitative evidence from Flanders
Bauwens, Thomas ULiege; Eyre, Nick

in Ecological Economics (2017), 137

Community-based energy organizations have been said to influence their members' energy-related behavior by activating social norms and by providing trustworthy information about sustainable energy ... [more ▼]

Community-based energy organizations have been said to influence their members' energy-related behavior by activating social norms and by providing trustworthy information about sustainable energy investments and behaviors. However, little is known yet about members' actual energy use and how it differs from that of individuals who do not participate in such projects. In particular, selection effects are likely to arise, i.e. community-based energy projects may attract people that are different from the underlying population in terms of energy use. This article empirically addresses the question of the selection into community-based energy projects in terms of energy use, focusing on the case of renewable energy cooperatives. Based on quantitative data from an original survey conducted with one renewable energy cooperative in Flanders and using probit regression analyses, it contrasts a sample of cooperative members with an appropriate comparison group in terms of electricity usage. The results show that electricity consumption is positively related with cooperative membership, suggesting that high use consumers have greater incentives to join a community-based organization which provides assistance and advice on the adoption of green technologies and energy efficiency measures. These findings contribute to an understanding of the relationship between community-based governance and sustainable energy practices. [less ▲]

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See detailThe influence of weathering and soil organic matter on Zn isotopes in soils
Opfergelt, Sophie; Cornelis, Jean-Thomas ULiege; Houben, David et al

in Chemical Geology (2017)

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See detailSemaglutide: a promising new glucagon-like peptide-1 receptor agonist.
Scheen, André ULiege

in Lancet Diabetes & Endocrinology (2017)

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See detailFibrillation auriculaire et anticoagulation chez le patient hémodialysé : une décision difficile
DELANAYE, Pierre ULiege; BOUQUEGNEAU, Antoine ULiege; DUBOIS, Bernard ULiege et al

in Néphrologie & Thérapeutique (2017)

Cardiovascular mortality of hemodialysis patients remains a major problem. The prevalence and incidence of atrial fibrillation in this population are more important than in the general population. The ... [more ▼]

Cardiovascular mortality of hemodialysis patients remains a major problem. The prevalence and incidence of atrial fibrillation in this population are more important than in the general population. The indication of antivitamin K therapy (AVK) in this context of atrial fibrillation must be weighted against the increased risk of bleeding. Unfortunately, and contrary to the general population, an indication of anticoagulation based on embolic or hemorrhagic risk scores is not as clearly established in the hemodialysis population. No prospective randomized study has investigated the benefit/risk balance of anticoagulant treatment in hemodialysis subjects. This article is a review of the current literature on this topic, showing the prevalence of thromboembolic but also bleeding events in the hemodialysis population. The impact of AVK treatment in this specific population is also reviewed. To the best of our knowledge, the indication of treatment must be individualized. [less ▲]

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See detailFormaliser le trope : De la subjectivité linguistique à la subjectivité épilinguistique
Mathy, Adrien ULiege

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Cartilage (2017)

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no ... [more ▼]

Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA. [less ▲]

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See detailDéficits de la conscience autonoétique et de la mémoire autobiographique: résultats d'une intervention cognitive dans la schizophrénie.
Boulanger, Marie ULiege; Neumann, Aurore; Blairy, Sylvie ULiege

in Pratiques Psychologiques (2017)

The study evaluates the effects of a cognitive intervention called Self-Awareness Therapy (SAT) on abilities of mental time travel in deficit in schizophrenia. Among whole schizophrenia participants ... [more ▼]

The study evaluates the effects of a cognitive intervention called Self-Awareness Therapy (SAT) on abilities of mental time travel in deficit in schizophrenia. Among whole schizophrenia participants, seven participated in SAT, four took part in the Integrative Program Therapy (IPT) and six followed a treatment as usual. Before and after interventions, participants were asked to complete TEMPau for autonoetic awareness and autobiographical memory such as TeMA, for autobiographical memory and projection into future events. Intragroups and individual statistical analyses were conducted. The participants of SAT intervention reported more specific past TEMPau and future specific events on TeMA after therapy. Results support that, in schizophrenia, the retrieving of past specific memories and projection into future specific events could be improved under certain conditions only. [less ▲]

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See detailDifferential interaction of synthetic glycolipids with biomimetic plasma membrane lipids correlates with plant biological response
Nasir, Mehmet Nail ULiege; Lins, Laurence ULiege; Crowet, Jean-Marc ULiege et al

in Langmuir (2017)

Natural and synthetic amphiphilic molecules including lipopeptides, lipopolysaccharides and glycolipids are able to induce defense mechanisms in plants. In the present work, the perception of two ... [more ▼]

Natural and synthetic amphiphilic molecules including lipopeptides, lipopolysaccharides and glycolipids are able to induce defense mechanisms in plants. In the present work, the perception of two synthetic C14 rhamnolipids, namely Alk-RL and Ac-RL, differing only at the level of the lipid tail terminal group, have been investigated using biological and biophysical approaches. We showed that Alk-RL induces a stronger early signaling response in tobacco cell suspensions than does Ac-RL. The interactions of both synthetic RLs with simplified biomimetic membranes were further analyzed using experimental and in silico approaches. Our results indicate that the interactions of Alk-RL and Ac-RL with lipids were different in terms of insertion and molecular responses and were dependent on the lipid composition of model membranes. A more favorable insertion of Alk-RL than Ac-RL into lipid membranes is observed. Alk-RL forms more stable molecular assemblies than Ac-RL with phospholipids and sterols. At the molecular level, the presence of sterols tends to increase the RLs’ interaction with lipid bilayers with a fluidizing effect on the alkyl chains. Taken together, our findings suggest that the perception of these synthetic RLs at the membrane level could be related to a lipid-driven process depending on the organization of the membrane and the orientation of the RLs within the membrane and is correlated with the induction of early signaling responses in tobacco cells. [less ▲]

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See detailCrassicauda boopis in a fin whale (Balaenoptera physalus) ship-struck in the eastern North Atlantic Ocean
Lempereur, Laetitia ULiege; Delobelle, Morgan; Doom, Marjan et al

in Parasitology open (2017), 3

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See detailChild Safety Reference Frameworks: a Policy Tool for Child Injury Prevention at the Sub-national Level
Scholtes, Béatrice ULiege; Schröder-Bäck, Peter; MacKay, Morag et al

in Central European Journal of Public Health (2017), 25(2), 120-128

Objectives: The aim of this paper is to present the Child Safety Reference Frameworks (CSRF), a policy advice tool that places evidence-based child safety interventions, applicable at the sub-national ... [more ▼]

Objectives: The aim of this paper is to present the Child Safety Reference Frameworks (CSRF), a policy advice tool that places evidence-based child safety interventions, applicable at the sub-national level, into a framework resembling the Haddon Matrix. Method: The CSRF is based on work done in previous EU funded projects, which we have adapted to the field of child safety. The CSRF were populated following a literature review. Results: Four CSRF were developed for four domains of child safety: road, water and home safety, and intentional injury prevention. Conclusion: The CSRF can be used as a reference, assessment and comparative tool by child safety practitioners and policy makers working at the sub-national level. [less ▲]

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See detailReconstructing Cenozoic vegetation from proxy data and models – A NECLIME synthesis (Editorial)
François, Louis ULiege; Bruch, A. A.; Utescher, T. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

[No abstract available]

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See detailNew crystallographic data and formula revision of phuralumite, Al2[(UO2)3(PO4)2O(OH)](OH)3(H2O)9
Dal Bo, Fabrice ULiege; Hatert, Frédéric ULiege; Philippo, S

in Journal of Geosciences (2017), 62

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See detailEmotional Phenomenology: Toward a Nonreductive Analysis
Dewalque, Arnaud ULiege

in Midwest Studies in Philosophy (2017), 41

In this article I want to create a presumption in favor of a nonreductive analysis of emotional phenomenology. The presumption relies on the claim that none of the nonemotional elements which are usually ... [more ▼]

In this article I want to create a presumption in favor of a nonreductive analysis of emotional phenomenology. The presumption relies on the claim that none of the nonemotional elements which are usually regarded as constitutive of emotional phenomenology may reasonably be considered responsible for the evaluative character of the latter. In section 1 I suggest this is true of cognitive elements, arguing that so-called ‘evaluative’ judgments usually result from emotional, evaluative attitudes, and should not be conflated with them. In section 2 I argue the same holds true for conative attitudes (desires and acts of the will). And in section 3 I briefly mention some salient aspects of the version of nonreductive analysis I lean toward. [less ▲]

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See detailMolecular dynamics study of micelle proeprties according to their size
Lebecque, Simon ULiege; Crowet, Jean-Marc ULiege; Nasir, Mehmet Nail ULiege et al

in Journal of Molecular Graphics and Modelling (2017), 72

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have ... [more ▼]

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have notably several applications in many domains, such as drug delivery or membrane protein solubilization. In this context, the study of micelle formation in relation with the structural and physico-chemical properties of surfactants is of great interest to better control their use in the different application fields. In this work, we use the MD approach developed by Yoshii et al. and extend it to surfactants with different structures. We aim to systematically investigate different micellar properties as a function of the aggregates size by a molecular dynamics approach, to get an insight into the micellar organization and to collect some relevant descriptors about micelle formation. For this, we perform short MD simulations of preformed micelles of various sizes and analyze three parameters for each micelle size, namely the eccentricity of the micelles, the hydrophobic/hydrophilic surface ratio and the hydrophobic tails hydration. If these parameters are known descriptors of micelles, they were not yet studied in this way by MD. We show that eccentricity, used as “validator” parameter, exhibits minimal values when the aggregate size is close to the experimental aggregation number for surfactants that are known to form spherical micelles. This hence indicates that our methodology gives consistent results. The evolution of the two descriptors follows another scheme, with a sharp increase and decrease, respectively, followed by a leveling-off. The aggregate sizes at which this stabilization starts to occur are close to the respective aggregation number of each surfactant. In our approach, we validate the use of these descriptors to follow micelle formation by MD, from “simple” surfactants to more complex structures, like lipopeptides. Our calculations also suggest that some peculiar behavior, like that of TPC, can be highlighted by our approach. In the context of peptidic surfactants, our methodology could further help to improve computer simulations combined to molecular thermodynamic models to predict micellar properties of those more complex amphiphilic molecules. [less ▲]

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See detailIntentionalisme et phénoménologie de l'intentionnalité
Seron, Denis ULiege

in Etudes Phénoménologiques - Phenomenological Studies (2017), 1

This paper presents an argument in favor of a “phenomenological” approach to intentionality. This approach, as I see it, involves the view that intentional facts are better expressed with the help of ... [more ▼]

This paper presents an argument in favor of a “phenomenological” approach to intentionality. This approach, as I see it, involves the view that intentional facts are better expressed with the help of appearance words (“seems”, “appears”, “is similar to”, etc.). By contrast, what I call the “intentionalist approach” assumes that intentional facts are better expressed by intentional verbs. The argument is as follows. First, it is well-known that the use of intentional verbs to express typically intentional facts generates anomalies with respect to existential generalization, substitution of identicals, and the principle of excluded middle. Secondly, I argue that the use of appearance words does not generate the same anomalies, which suggests that appearance words are more appropriate to describe intentional facts. This, I conclude, is an argument for preferring the phenomenological to the intentionalist approach to intentionality. [less ▲]

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See detailChemical Composition of Distilled Essential Oils and Hydrosols of Four Senegalese Citrus and Enantiomeric Characterization of Chiral Compounds
Ndiaye, El Hadji Barka; Gueye, Momar Talla; Ndiaye, Ibrahima et al

in Journal of Essential Oil-Bearing Plants [=JEOBP] (2017), 20(3), 820-834

Peels of four local Citrus species (Citrus sinensis L. Obsbeck, Citrus reticulata Blanco, Citrus maxima Burm. and Citrus aurantifolia christm.) grown in a same locality under the same climatic conditions ... [more ▼]

Peels of four local Citrus species (Citrus sinensis L. Obsbeck, Citrus reticulata Blanco, Citrus maxima Burm. and Citrus aurantifolia christm.) grown in a same locality under the same climatic conditions were subjected to steam distillation. The essential oils and floral waters obtained were analyzed by gas chromatography coupled with a flame ionization detector (CPG-FID) and by gas chromatography coupled to a mass spectrometer (CPG-MS). The essential oils yields were ranged between 0.2 and 0.7 %. The qualitative and quantitative analyses show 74 compounds in all oils samples. The oils were largely dominated by hydrocarbon monoterpenes with limonene as major compound (91.5-94.0 %; 90.4-93.4 %; 77.7-93.7 % and 34.8-51.2 %) in oils from Citrus sinensis, Citrus reticulata, Citrus maxima and Citrus aurantifolia, respectively. In addition to limonene, oils of Citrus aurantifolia contained high amounts of β-pinene (6.8-14.4 %), pcymene (5.8-12.2 %), γ-terpinene (0.3 -7.4 %), neral (1.5-9.4 %), geraniol (1.9-12.7 %). Although presenting the same major compound (limonene), the oils had compositions that were qualitatively and quantitatively different. The enantiomeric analyses showed that the chiral major compounds were (R) - (+) - limonene, (S) - (-) – limonene, (1S) - (-) -β-pinene, (1R)-(+)-β-pinene and (S) - (+) - carvone. The hydrosols analyzed were composed of oxygenated compounds and did not have the same major compound. A qualitative and quantitative difference in chemical composition was noted between the Hydrosols. [less ▲]

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See detailAntiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents
Jansen, Olivia ULiege; Tchinda, Alembert T.; Loua, Jean et al

in Journal of Ethnopharmacology (2017), 203(March), 20--26

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See detailDetection of a persistent meteoric metal layer in the Martian atmosphere
Crismani, M. M. J.; Schneider, N. M.; Plane, J. M. C. et al

in Nature Geoscience (2017), 10(6), 401-404

Interplanetary dust particles sporadically enter planetary atmospheres at orbital velocities and ablate as collisions occur with ambient gases to produce a persistent layer of metallic atoms (for example ... [more ▼]

Interplanetary dust particles sporadically enter planetary atmospheres at orbital velocities and ablate as collisions occur with ambient gases to produce a persistent layer of metallic atoms (for example, Fe, Mg, Na) in their upper atmospheres. Such layers are well studied at Earth, but have not been directly detected elsewhere in the Solar System. Here we report the detection of a meteoric layer consisting of Mg+ ions near an altitude of 90 km in the Martian atmosphere from ultraviolet remote sensing observations by NASA's MAVEN spacecraft. We observe temporal variability in the Mg+ layer over the course of a Martian year, moving up and down in altitude seasonally and in response to dust storms, and displaying diurnal fluctuations in density. We also find that most meteor showers do not significantly perturb this layer, which constrains the fluence of eleven observed Martian meteor showers to less than our estimated global dust flux. The persistence and variability of the Mg+ layer are difficult to explain with existing models and reconcile with other transient layers of ions observed in the Martian ionosphere. We suggest that the transient layers are not sourced from the persistent Mg+ layer and thus not derived from meteoric material, but are ambient ions produced by some unknown mechanism. © 2017 Macmillan Publishers Limited, part of Springer Nature. [less ▲]

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See detailNew Minerals, Nomenclature and Classification (CNMNC), Newsletter 36. New minerals and nomenclature modifications approved in 2016 and 2017
Halenius, U; Hatert, Frédéric ULiege; Pasero, M et al

in Mineralogical Magazine (2017), 81

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See detailPotential contribution of progesterone receptors to the development of sexual behavior in male and female mice.
Desroziers, Elodie; Brock, Olivier; Bakker, Julie ULiege

in Hormones and Behavior (2017)

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in ... [more ▼]

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in adulthood, whereas prepubertal estradiol feminized this ability. Furthermore, we found that estradiol upregulates progesterone receptors (PR) during development, inducing both a male-and female-typical pattern of PR expression in the mouse hypothalamus. In the present study, we took advantage of a newly developed PR antagonist (ZK 137316) to determine whether PR contributes to either male- or female-typical sexual differentiation. Thus groups of male and female C57Bl/6j mice were treated with ZK 137316 or oil as control: males were treated neonatally (P0-P10), during the critical period for male sexual differentiation, and females were treated prepubertally (P15-P25), during the critical period for female sexual differentiation. In adulthood, mice were tested for sexual behavior. In males, some minor effects of neonatal ZK treatment on sexual behavior were observed: latencies to the first mount, intromission and ejaculation were decreased in neonatally ZK treated males; however, this effect disappeared by the second mating test. By contrast, female mice treated with ZK during the prepubertal period showed significantly less lordosis than OIL-treated females. Mate preferences were not affected in either males or females treated with ZK during development. Taken together, these results suggest a role for PR and thus perhaps progesterone in the development of lordosis behavior in female mice. By contrast, no obvious role for PR can be discerned in the development of male sexual behavior. [less ▲]

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See detailIdentification of an essential virulence gene of cyprinid herpesvirus 3.
Boutier, Maxime ULiege; Gao, Yuan; Vancsok, Catherine ULiege et al

in Antiviral Research (2017), 145

The genus Cyprinivirus consists of a growing list of phylogenetically related viruses, some of which cause severe economic losses to the aquaculture industry. The archetypal member, cyprinid herpesvirus 3 ... [more ▼]

The genus Cyprinivirus consists of a growing list of phylogenetically related viruses, some of which cause severe economic losses to the aquaculture industry. The archetypal member, cyprinid herpesvirus 3 (CyHV-3) causes mass mortalities worldwide in koi and common carp. A CyHV-3 mutant was described previously that is attenuated in vivo by a deletion affecting two genes (ORF56 and ORF57). The relative contributions of ORF56 and ORF57 to the safety and efficacy profile of this vaccine candidate have now been assessed by analysing viruses individually deleted for ORF56 or ORF57. Inoculation of these viruses into carp demonstrated that the absence of ORF56 did not affect virulence, whereas the absence of ORF57 led to an attenuation comparable to, though slightly less than, that of the doubly deleted virus. To demonstrate further the role of ORF57 as a key virulence factor, a mutant retaining the ORF57 region but unable to express the ORF57 protein was produced by inserting multiple in-frame stop codons into the coding region. Analysis of this virus in vivo revealed a safety and efficacy profile comparable to that of the doubly deleted virus. These findings show that ORF57 encodes an essential CyHV-3 virulence factor. They also indicate that ORF57 orthologues in other cypriniviruses may offer promising targets for the rational design of attenuated recombinant vaccines. [less ▲]

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See detailMethane in the South China Sea and the Western Philippine Sea
Tseng, Hsiao-Chun; Chen, Chen-Tung Arthur; Borges, Alberto ULiege et al

in Continental Shelf Research (2017), 135

Approximately 700 water samples from the South China Sea (SCS) and 300 water samples from the western Philippine Sea (wPS) were collected during eight cruises from August 2003 to July 2007 to determine ... [more ▼]

Approximately 700 water samples from the South China Sea (SCS) and 300 water samples from the western Philippine Sea (wPS) were collected during eight cruises from August 2003 to July 2007 to determine methane (CH4) distributions from the surface to a depth of 4250 m. The surface CH4 concentrations exceeded atmospheric equilibrium, both in the SCS and the wPS, and the concentrations were 4.5±3.6 and 3.0±1.2 nmol L−1, respectively. The sea-to-air fluxes were calculated, and the SCS and the wPS were found to emit CH4 to the atmosphere at 8.6±6.4 µmol m−2 d−1 and 4.9±4.9 µmol m−2 d−1, respectively. In the SCS, CH4 emissions were higher over the continental shelf (11.0±7.4 µmol m−2 d−1) than over the deep ocean (6.1±6.0 µmol m−2 d−1), owing to greater biological productivity and closer coupling with the sediments on the continental shelf. The SCS emitted 30.1×106 mol d−1 CH4 to the atmosphere and exported 1.82×106 mol d−1 CH4 to the wPS. The concentrations of both CH4 and chlorophyll a were high in the 150 m surface layer of the wPS, but were not significantly correlated with each other. CH4 concentrations generally declined with increasing depth below the euphotic zone but remained constant below 1,000 m, both in the SCS and the wPS. Some high CH4 concentrations were observed at mid-depths and bottom waters in the SCS, and were most likely caused by the release of CH4 from gas hydrates or gas seepage. [less ▲]

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See detailEndothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance
Watt, NT; Gage, MC; Patel, PA et al

in Diabetes (2017)

Shc homology 2-containing inositol 5´ phosphatase-2 (SHIP2) is as lipid phosphatase which inhibits insulin signaling downstream of phosphoinositide-3-kinase (PI3K); its role in vascular function is poorly ... [more ▼]

Shc homology 2-containing inositol 5´ phosphatase-2 (SHIP2) is as lipid phosphatase which inhibits insulin signaling downstream of phosphoinositide-3-kinase (PI3K); its role in vascular function is poorly understood. To examine its role in endothelial cell (EC) biology, we generated mice with catalytic inactivation of one SHIP2 allele selectively in EC (ECSHIP2Δ/+). Hyperinsulinemic euglycemic clamping studies revealed ECSHIP2Δ/+ were resistant to insulin-stimulated glucose uptake in adipose tissue and skeletal muscle, compared with littermate controls. EC from ECSHIP2Δ/+ had increased basal expression and activation of PI3K downstream targets, including Akt and endothelial nitric oxide synthase (eNOS), although incremental activation by insulin and shear stress was impaired. Insulin-mediated vasodilation was blunted in ECSHIP2Δ/+, as was aortic nitric oxide bioavailability. Acetylcholine-induced vasodilation was also impaired in ECSHIP2Δ/+, which was exaggerated in the presence of a superoxide dismutase/catalase mimetic. Superoxide abundance was elevated in ECSHIP2Δ/+ EC, and was suppressed by PI3K and Nox2 NADPH oxidase inhibitors. These findings were phenocopied in healthy human EC after SHIP2 silencing. Our data suggest that endothelial SHIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced endothelial dysfunction. [less ▲]

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See detailVulnerability evaluation of millet and sorghum cropping system to climate change and adoption of new technologies in Mali
Sissoko, Penda ULiege; Aune, Jens B.; Senneväg, Gry et al

in Asian Journal of Science and Technology (2017), 8(1), 4176-4182

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi ... [more ▼]

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi-structured interviews (ISS) using questionnaires addressed to the chiefs of family farm (FAE) were used for the collection of data. The descriptive statistics and matrices were realized for the data analysis using the following softwares: EXCEL and SPSS20.The results of the surveys conducted in 2014 among 360 farms in Sahelian and Sudano-Sahelian areas, shows that agricultural producers are aware of the main factors affecting the productivity of their cropping system and food security of agricultural holdings. Rainfall variability, characterized by failure and irregularity of rains is the main constraint of cropping systems based on millet and sorghum as stated by 97% of surveyed producers, followed by soil poverty 81%, and the lack of agricultural equipment 47%. The impacts of these factors at the farms level are translated by a decrease in the crops yields and on the frequency of the shortages in foodstuffs which are observed by 98% of the farms every year and more than 50% every 3 years. To reduce vulnerabilities, practices and innovations were adopted by farms as strategies. The main concern fertilizer micro dosing technics, seed soaking, improved varieties, organic and mineral fertilization, soils and water management technics, mechanical sowing, and agro forestry were adopted as strategies. [less ▲]

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See detailRecommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography
Baumgartner, HC; Hung, J Co-Chair; Bermejo, J et al

in European Heart Journal - Cardiovascular Imaging (2017)

Echocardiography is the key tool for the diagnosis and evaluation of aortic stenosis. Because clinical decision-making is based on the echocardiographic assessment of its severity, it is essential that ... [more ▼]

Echocardiography is the key tool for the diagnosis and evaluation of aortic stenosis. Because clinical decision-making is based on the echocardiographic assessment of its severity, it is essential that standards are adopted to maintain accuracy and consistency across echocardiographic laboratories. Detailed recommendations for the echocardiographic assessment of valve stenosis were published by the European Association of Echocardiography and the American Society of Echocardiography in 2009. In the meantime, numerous new studies on aortic stenosis have been published with particular new insights into the difficult subgroup of low gradient aortic stenosis making an update of recommendations necessary. The document focuses in particular on the optimization of left ventricular outflow tract assessment, low flow, low gradient aortic stenosis with preserved ejection fraction, a new classification of aortic stenosis by gradient, flow and ejection fraction, and a grading algorithm for an integrated and stepwise approach of artic stenosis assessment in clinical practice. [less ▲]

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See detailExploring the effects of seismicity on landslides and catchment sediment yield: An Italian case study
Vanmaercke, Matthias ULiege; Ardizzone, F.; Rossi, M. et al

in Geomorphology (2017), 278

Recent studies showed that contemporary average catchment sediment yields (SY, [t km− 2 y− 1]) at regional and continental scales are often strongly correlated to spatial patterns of seismic activity ... [more ▼]

Recent studies showed that contemporary average catchment sediment yields (SY, [t km− 2 y− 1]) at regional and continental scales are often strongly correlated to spatial patterns of seismic activity. Nonetheless, we currently have little insights into the mechanisms that explain these correlations. We investigated how spatial patterns of SY in Italy are linked to patterns of seismic activity. For a dataset of 103 Italian catchments with average SY measured over a period of years to decades, we extracted tectonic and none-tectonic variables that potentially explain observed differences in SY. These include proxies for vertical uplift rates and cumulative seismic moments (CSM) associated with historic earthquakes of different ranges of magnitude. Results showed that also across Italy, SY is significantly correlated to seismicity. However, SY showed much stronger correlations with proxies of seismicity relating to small but frequent earthquakes (2 ≤ Mw < 4) than with proxies relating to tectonic uplift or large, potentially landslide-triggering earthquakes (Mw ≥ 4). Analyses of a dataset of about 500,000 landslides across Italy showed very comparable trends: spatial patterns of landslides within similar lithological units generally show a significant positive correlation with CSM of weak but frequent seismicity and generally not with CSM of large earthquakes. These results suggest that, on a decadal time scale and at a regional/continental spatial scale, frequent but relatively weak seismicity may exert a more important geomorphic impact than large earthquake events or tectonic uplift. © 2016 Elsevier B.V. [less ▲]

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See detailDrying recycled fiber rejects in a bench-scale cyclone: Influence of device geometry and operational parameters on drying mechanisms
Grimm, Alejandro; Elustondo, Diego; Mäkelä, Mikko et al

in Fuel Processing Technology (2017), 167

Abstract Significant amounts of waste sludge and rejects are generated by pulp and paper mills, and stricter environmental regulations have made waste handling a global challenge. Thermochemical ... [more ▼]

Abstract Significant amounts of waste sludge and rejects are generated by pulp and paper mills, and stricter environmental regulations have made waste handling a global challenge. Thermochemical conversion of mechanically dewatered by-products is expensive and inefficient due to their high moisture content; therefore drying is a vital unit operation in waste management. This paper reports results from drying of light coarse fiber reject in a bench-scale cyclone that allows changes in geometry. For the sake of comparison, convective fixed-bed drying tests were also performed. The results showed that the drying rate in the cyclone was hundreds of times higher than in the fixed-bed. For cyclone drying, the inlet air velocity was the most important factor in both determining the drying rate and residence time of the material. This led to the hypothesis that grinding of the reject particles due to particle-wall and particle-particle collisions play a crucial role in enhancing the efficiency of heat and mass transfer. In addition to inlet air velocity, cyclone geometry was the main factor that determined particle residence time, as drying air temperature mainly determined drying rate. [less ▲]

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See detailEcotoxicoproteomic assessment of the functional alterations caused by chronic metallic exposures in gammarids
Gismondi, Eric ULiege; Thomé, Jean-Pierre ULiege; Urien, Nastassia et al

in Environmental Pollution (2017)

Very few ecotoxicological studies have been performed on long-term exposure under controlled conditions, hence limiting the assessment of the impact of chronic and diffuse chemical pressures on the health ... [more ▼]

Very few ecotoxicological studies have been performed on long-term exposure under controlled conditions, hence limiting the assessment of the impact of chronic and diffuse chemical pressures on the health of aquatic organisms. In this study, an ecotoxicoproteomic approach was used to assess the integrated response and possible acclimation mechanisms in Gammarus fossarum following chronic exposures to Cd, Cu or Pb, at environmentally realistic concentrations (i.e. 0.25, 1.5 and 5 µg/L respectively). After 10-week exposure, changes in protein expression were investigated in caeca of control and exposed males. Gel-free proteomic analyses allowed for the identification of 35 proteins involved in various biological functions, for which 23 were significantly deregulated by metal exposures. The protein deregulation profiles were specific to each metal, providing evidence for metal-specific action sites and responses of gammarids. Among the tested metals, Cu was the most toxic in terms of mortality, probably linked with persistent oxidative stress. Moulting and osmoregulation were the major biological functions affected by Cu in the long-term. In Pb-exposed gammarids, significant deregulations of proteins involved in immune response and cytoskeleton were observed. Reproduction appears to be strongly affected in gammarids chronically exposed to Cd or Pb. Besides, modified expressions of several proteins involved in energy transfer and metabolism highlighted important energetic reshuffling to cope with chronic metal exposures. These results support the fact that metallic pressures induce a functional and energetic cost for individuals of G. fossarum with potential repercussions on population dynamics. Furthermore, this ecotoxicoproteomic study offers promising lines of enquiry in the development of new biomarkers that could make evidence of long-term impacts of metals on the health of organisms. [less ▲]

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See detailImaging of Vanadium in Microfossils: A New Potential Biosignature
Marshall, C.P.; Marshall, A.O.; Aitken, J.B. et al

in Astrobiology (2017), 17(11), 1-8

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See detailOutcomes of UCB transplantation are comparable in FLT3+ AML: Results of CIBMTR, eurocord and EBMT collaborative analysis.
Ustun, C.; Giannotti, F.; Zhang, M.-J. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2017)

Allogeneic hematopoietic cell transplantation (HCT) from siblings or unrelated donors (URD) during complete remission (CR) may improve leukemia-free survival (LFS) in FLT3+ acute myeloid leukemia (AML ... [more ▼]

Allogeneic hematopoietic cell transplantation (HCT) from siblings or unrelated donors (URD) during complete remission (CR) may improve leukemia-free survival (LFS) in FLT3+ acute myeloid leukemia (AML) that has poor prognosis due to high relapse rates. Umbilical cord blood (UCB) HCT outcomes are largely unknown in this population. We found that compared with sibling HCT, relapse risks were similar after UCB (n=126), (HR 0.86, P=0.54) and URD (n=91) (HR 0.81, P=0.43). UCB HCT was associated with statistically higher non-relapse mortality compared with sibling HCT (HR 2.32, P=0.02), but not vs URD (HR 1.72, P=0.07). All three cohorts had statistically not significant 3-year LFS: 39% (95% CI 30-47) after UCB, 43% (95% CI 30-54) after sibling, and 50% (95% CI 40-60) after URD. Chronic GVHD rates were significantly lower after UCB compared with either sibling (HR 0.59, P=0.03) or URD (HR 0.49, P=0.001). Adverse factors for LFS included high leukocyte count at diagnosis and HCT during CR2. UCB is a suitable option for adults with FLT3+AML in the absence of an HLA-matched sibling and its immediate availability may be particularly important for FLT3+ AML where early relapse is common thus allowing HCT in CR1 when outcomes are best.Leukemia accepted article preview online, 25 January 2017. doi:10.1038/leu.2017.42. [less ▲]

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See detailSpecies delimitation in the recalcitrant moss genus Rhynchostegiella (Brachytheciaceae)
Patiño, J.; Hedenäs, L.; Dirkse, G. et al

in Taxon (2017), 66

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See detailChanges in biophysical membrane properties induced by the Budesonide/ Hydroxy-β-cyclodextrin complex
dos Santos, Andreia; Bayiha, Jules; Dufour, Gilles et al

in BBA Biomembranes (2017)

Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a ... [more ▼]

Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a biocompatible cyclodextrin known to interact with cholesterol, is used as a drug-solubilizing agent in pharmaceutical formulations. Budesonide administered as an inclusion complex within HPβCD (BUD:HPβCD) required a quarter of the nominal dose of the suspension formulation and significantly reduced neutrophil induced inflammation in a COPD mouse model exceeding the effect of each molecule administered individually. This suggests the role of lipid domains enriched in cholesterol for inflammatory signaling activation. In this context, we investigated the effect of BUD:HPβCD on the biophysical properties of membrane lipids. On cellular models (A549, lung epithelial cells), BUD:HPβCD extracted cholesterol similarly to HPβCD. On large unilamellar vesicles (LUVs), by using the fluorescent probes diphenylhexatriene (DPH) and calcein, we demonstrated an increase in membrane fluidity and permeability induced by BUD:HPβCD in vesicles containing cholesterol. On giant unilamellar vesicles (GUVs) and lipid monolayers, BUD:HPβCD induced the disruption of cholesterol-enriched raft-like liquid ordered domains as well as changes in lipid packing and lipid desorption from the cholesterol monolayers, respectively. Except for membrane fluidity, all these effects were enhanced when HPβCD was complexed with budesonide as compared with HPβCD. Since cholesterol-enriched domains have been linked to membrane signaling including pathways involved in inflammation processes, we hypothesized the effects of BUD:HPβCD could be partly mediated by changes in the biophysical properties of cholesterol-enriched domains. [less ▲]

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See detailOf Pins and Beads: Note on a Feminine Costume in Mari
Couturaud, Barbara ULiege

in Ash Sharq. Bulletin of the Ancient Near East: Archaeological, Historical And Societal Studies (2017), 1

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See detailAnalyse de la rentabilité financière de la production de semence du riz au Bénin
Dossouhoui, François Vihôdé ULiege; Agossou S.M., Désiré; Adégbidi, Anselme et al

in Journal of Applied Biosciences (2017), (May 2017), 11267-11275

Objectif : Cette étude vise, à travers une analyse de la rentabilité financière, à mettre en exergue l’intérêt que peut susciter la production de semences de qualité dans les divers systèmes de production ... [more ▼]

Objectif : Cette étude vise, à travers une analyse de la rentabilité financière, à mettre en exergue l’intérêt que peut susciter la production de semences de qualité dans les divers systèmes de production et la place du secteur privé dans la gestion du système semencier. Méthodologie et résultats : L’étude a été conduite auprès d’un échantillon de 57 producteurs de semences certifiées et de riz de consommation choisis de façon aléatoire dans trois départements : Mono, Zou et Collines où trois systèmes de production se côtoient. Il a été fait recours à la méthode d’analyse de marges et les résultats ont été comparés chaque fois à la production de riz de consommation par système de production : riz pluvial, riz de bas-fonds et riz irrigué. Il en résulte que la production de semences est plus rentable et l’est davantage dans le système d’irrigation. Conclusion et application des résultats : La présente étude a été conduite dans un contexte où l’État est intervenu pour promouvoir l’accès aux semences améliorées suite à la crise alimentaire de 2008. L’État, à travers son dispositif de vulgarisation organise, la collecte de semences auprès des producteurs multiplicateurs accrédités et subventionne la redistribution aux producteurs de riz de consommation. L’intérêt que porte cette étude sur la rentabilité financière de l’activité de production de semences certifiées réside dans la nécessité de disposer de données fiables pour susciter l’implication des entreprises privées dans le système semencier et faciliter l’accès aux crédits pour les multiplicateurs de semences. Pour un système compétitif et adéquat aux besoins des producteurs, il est impérieux de réfléchir sur un partenariat compagnies privées de distribution et producteurs multiplicateurs de semences certifiées. Ce dispositif facilitera la disponibilité et l’accès à un prix abordable aux semences de qualité pour les producteurs du riz. [less ▲]

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See detailLandslide risk reduction measures: a review of practices and challenges for the tropics
Maes, Jan; Kervyn, Matthieu; de Hontheim, Astrid et al

in Progress in Physical Geography (2017)

The overall objective of this review is to gain insights into landslide risk reduction measures that are applied or recommended in tropical landslide-prone countries, and the challenges at play. More ... [more ▼]

The overall objective of this review is to gain insights into landslide risk reduction measures that are applied or recommended in tropical landslide-prone countries, and the challenges at play. More specifically, this review aims to (i) presenting an overview of recent studies on landslides and landslide risk reduction in these countries, (ii) exploring the factors controlling the publication output on landslides and landslide risk reduction, (iii) reviewing the various landslide risk reduction measures recommended and implemented, and (iv) identifying the bottlenecks for the implementation of these strategies. A compilation of recommended and implemented landslide risk reduction measures in 99 landslide-prone tropical countries was made, based on an extensive review of scientific literature (382 publications). The documented measures are analysed Corresponding author: Jan Maes, Department of Earth & Environmental Sciences, KU Leuven, Celestijnenlaan 200E 03.256, Heverlee B-3001, Belgium. Email: maes.jan@kuleuven.be Progress in Physical Geography 1–31 ª The Author(s) 2017 Reprints and permission: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0309133316689344 journals.sagepub.com/home/ppg using a scheme of risk reduction measures that combines classifications of the Hyogo Framework for Action and the SafeLand project. Our literature review shows that the factors influencing the number of publications on landslides and landslide risk reduction per country are (in order of importance) the absolute physical exposure of people to landslides, the population number and the Human Development Index of a country. The ratio of publications on landslide risk reduction versus publications on landslides for landslide-prone tropical countries does not vary much between these countries (average: 0.28). A significant fraction (0.30) of all known landslide hazard reduction measures are neither implemented nor recommended according to our review. The most recommended landslide risk reduction component is ‘risk management and vulnerability reduction’ (0.38). However, the most implemented component is ‘risk assessment’ (0.57). Overall, the ratio of implemented versus recommended landslide risk reduction measures in the tropics is low (<0.50) for most landslide risk reduction components, except for ‘risk assessment’ (3.01). The most cited bottlenecks for implementing landslide risk reduction measures are scientific (0.30) and political (0.29) in nature. [less ▲]

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See detailPrevalence of sarcopenia in a population of nursing home residents according to their frailty status: results of the SENIOR cohort
Buckinx, Fanny ULiege; Reginster, Jean-Yves ULiege; BRUNOIS, Théo ULiege et al

in Journal of Musculoskeletal & Neuronal Interactions (2017), 17(3), 209-17

Objective: To investigate the relationship between frailty and sarcopenia, by evaluating the prevalence of sarcopenia among frail, pre-frail and robust elderly nursing home residents in Belgium. Methods ... [more ▼]

Objective: To investigate the relationship between frailty and sarcopenia, by evaluating the prevalence of sarcopenia among frail, pre-frail and robust elderly nursing home residents in Belgium. Methods: This is an analysis of baseline data collected from the SENIOR (Sample of Elderly Nursing home Individuals: an Observational Research) cohort. All subjects received a sarcopenia evaluation, based on the definition proposed by the European Working Group on Sarcopenia in Older People (EWGSOP). The frailty evaluation was primarily based on FRIED’s definition but also on 9 other operational definitions. Results: A total of 662 subjects (73.1% of women) were included in this analysis (mean age: 83.2±8.99 years). The prevalence of sarcopenia was 38.1% whereas the prevalence of frail and pre-frail persons was respectively 24.7% and 61.4%. Among frail, pre-frail and robust subjects, respectively 47%, 38.9% and 16.3% were diagnosed sarcopenic. The prevalence of sarcopenia according to ten different operational definitions of frailty ranged between 32.8 % (i.e. Frail scale Status and Frailty Index) and 47% (i.e. Fried definition). Conclusion: This research highlights that over a third of nursing home residents are sarcopenic and the percentage is almost 50% among frail subjects; those latter constitute about 1 in 4 of the population of nursing home residents studied here. [less ▲]

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See detailRemembering Beyond Words: Jazz and Musicality in Caryl Phillips’s Crossing the River
Mascoli, Giulia ULiege

in Lamar Journal of the Humanities (2017), XLII(Spring), 5-22

The main focus in this article is to show why Caryl Phillips’s Crossing the River can be considered a jazz novel and specifically how its rhythmic quality is achieved. The article also seeks to develop an ... [more ▼]

The main focus in this article is to show why Caryl Phillips’s Crossing the River can be considered a jazz novel and specifically how its rhythmic quality is achieved. The article also seeks to develop an informed understanding of Phillips’s use of music in a way that reflects its significance in the postcolonial context. [less ▲]

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See detailMolecular mechanisms, current management and next generation therapy in myeloma bone disease.
Heusschen, Roy ULiege; Muller, Joséphine ULiege; Duray, Elodie ULiege et al

in Leukemia & Lymphoma (2017)

Multiple myeloma (MM) bone disease is a major cause of morbidity and mortality in MM patients and persists even in patients in remission. This bone disease is caused by an uncoupling of bone remodeling ... [more ▼]

Multiple myeloma (MM) bone disease is a major cause of morbidity and mortality in MM patients and persists even in patients in remission. This bone disease is caused by an uncoupling of bone remodeling, with increased osteoclast and decreased osteoblast activity and formation, culminating in lytic bone destruction. Bisphosphonates are the current standard of care but new therapies are needed. As the molecular mechanisms controlling MM bone disease are increasingly well understood, new therapeutic targets are extensively explored in the preclinical setting and initial clinical trials with novel compounds now show promising results. In this review, we will provide a comprehensive overview of the biology of MM bone disease, summarize its current clinical management and discuss preclinical and clinical data on next generation therapies. [less ▲]

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See detailA survey on migraine attack treatment with the CEFALY® device in regular users
Penning, Sophie; SCHOENEN, Jean ULiege

in Acta Neurologica Belgica (2017)

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See detailThe same but different: stable isotopes reveal two distinguishable, yet similar, neighbouring food chains in a coral reef
Le Bourg, Baptiste ULiege; Letourneur, Yves; Bănaru, Daniela et al

in Journal of the Marine Biological Association of the United Kingdom (2017)

Stable isotope compositions were studied in particulate organic matter (POM), zooplankton and different trophic groups of teleosts to compare food chains based on plankton at two sites (lagoon and outer ... [more ▼]

Stable isotope compositions were studied in particulate organic matter (POM), zooplankton and different trophic groups of teleosts to compare food chains based on plankton at two sites (lagoon and outer slope) in a New Caledonian coral reef. For each trophic compartment, d13C values were always lower in the outer slope than in the lagoon. This result may be explained by potential differences in POM composition between the two environments, suggesting that the two food chains are based on different primary sources of carbon. In contrast, d15N values did not vary between the lagoon and the outer slope, indicating that these two food chains presented similar length and trophic levels, despite being distinguishable. [less ▲]

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See detailPsychopathologie phénoménologique : Apports contemporains et défis futurs
Englebert, Jérôme ULiege

in Neurone (2017), 22(7),

Cet article retrace l’historique de la psychopathologie phénoménologique, née il y a 100 ans, et fait la synthèse des apports de la phénoménologie à la psychopathologie. Il a pour objectif, d’une part, de ... [more ▼]

Cet article retrace l’historique de la psychopathologie phénoménologique, née il y a 100 ans, et fait la synthèse des apports de la phénoménologie à la psychopathologie. Il a pour objectif, d’une part, de présenter l’un des apports récents de la psychopathologie phénoménologique à la connaissance d’une maladie mentale incontournable, à savoir la schizophrénie et, d’autre part, de souligner les défis et d’esquisser les perspectives et projets que cette discipline renaissante semble susciter. [less ▲]

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See detailExperimental observation of the Poincaré-Birkhoff scenario in a driven many-body quantum system
Tomkovic, Jiri; Muessel, Wolfgang; Strobel, Helmut et al

in Physical Review A (2017), 95

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See detailEvidence of a fine-scale genetic structure for the endangered Pyrenean desman (Galemys pyrenaicus) in the French Pyrenees
Gillet, F; Cabria, M.; Blanc, F. et al

in Journal of Mammalogy (2017)

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing mountain streams. This species is currently classified as vulnerable on the IUCN Red List and has been undergoing habitat loss and fragmentation for decades, inevitably impacting its distribution. A recent genetic study, based on mitochondrial and intronic sequences, showed that the genetic variability of the Pyrenean desman is very low in the Pyrenees. In this study, we investigated the potential existence of genetic structure and gene flow at a smaller scale using 24 polymorphic microsatellite loci. As the Pyrenean desman is a very elusive species, we supplemented our tissue sample collection with samples of feces collected in the French range of this species. We successfully identified 70 individuals based on 355 fecal samples. Bayesian analyses revealed 3 genetic and geographic clusters (1 eastern, 1 central, and 1 western, including 3 genetic sub-clusters), with origins tracing back only 200 years. These clusters were characterized by low levels of genetic diversity and high inbreeding coefficients. Although gene flow among clusters appeared to be limited, populations seem to have exchanged alleles recently. Therefore, connectivity between watersheds should be enhanced to maintain genetic diversity and potentially improve the long-term survival of the Pyrenean desman in France [less ▲]

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See detailGenetic variabilitly in Tunisian populations of faba bean (Vicia faba L. var. major) assessed by morphological and SSR markers
Rebaa, Feten; Abid, Ghassen; Aouida, Marwa et al

in Physiology and Molecular Biology of Plants (2017)

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See detailAbondance et diversité des communautés lombriciennes dans la Réserve et Domaine de Chasse de Bombo-Lumene (Kinshasa)
Milau Empwal, Fils; Lemtiri, Aboulkacem ULiege; KIFUKIETO MANZANZA, Carmel et al

in Int. J. Biol. Chem. Sci (2017)

Les vers de terre sont des espèces importantes des écosystèmes édaphiques dotées des capacités de transformer leur biotope et même parfois de créer de nouveaux habitats pour d’autres organismes. En effet ... [more ▼]

Les vers de terre sont des espèces importantes des écosystèmes édaphiques dotées des capacités de transformer leur biotope et même parfois de créer de nouveaux habitats pour d’autres organismes. En effet, ils modifient la morphologie, la structure et la composition du sol par leur action à la fois physique, chimique et biologique. Ils ont ainsi une implication intéressante dans la fertilité et le cycle des nutriments du sol. Cette étude a été effectuée dans la Réserve et Domaine de Chasse de Bombo-Lumene (RDCBL) à Kinshasa. Elle avait pour objectif d’évaluer l’effet de l’occupation du sol sur la composition et la structure des communautés lombriciennes. Dix-huit parcelles regroupées en 6 biotopes ont été échantillonnées: les forêts denses semi décidues, les galeries forestières, les recrûs forestiers, les savanes arborescentes, les savanes herbeuses, et les sols sous culture. Au total, 10 espèces de vers de terre ont été identifiées. Elles appartiennent aux deux grandes familles tropicales : celle des Acanthodrilidae et celle des Eudrilidae. Les biotopes naturels sont les plus riches en termes de richesse d’espèces comparés aux biotopes les plus anthropisés. Dans cette étude, le type d’occupation du sol affecte considérablement la diversité des vers de terre. [less ▲]

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See detailConserved genomic collinearity as a source of broadly applicable, fast evolving, markers to resolve species complexes: A case study using the lichen-forming genus Peltigera section Polydactylon
Magain, Nicolas ULiege; Miadlikowska, Jolanta; Mueller, Olaf et al

in Molecular Phylogenetics & Evolution (2017), xxx(xxx),

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See detailL’IMAGE DU MOIS.Une tumeur cardiaque indéterminée
RADERMECKER, Régis ULiege; RENSON, Virginie ULiege; Delvenne, Philippe ULiege et al

in Revue Médicale de Liège (2017), 72(1), 4-5

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See detailLand use change affects biogenic silica pool distribution in a subtropical soil toposequence
Unzue-Belmonte, Dacil; Ameijeiras-Marino, Yolanda; Opfergelt, Sophie et al

in Solid Earth (2017)

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See detailNonlinear system identification in structural dynamics: 10 more years of progress
Noël, Jean-Philippe ULiege; Kerschen, Gaëtan ULiege

in Mechanical Systems & Signal Processing (2017), 83

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved ... [more ▼]

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved until then, it was concluded that the identification of simple continuous structures with localised nonlinearities was within reach. The past decade witnessed a shift in emphasis, accommodating the growing industrial need for a first generation of tools capable of addressing complex nonlinearities in larger-scale structures. The objective of the present paper is to survey the key developments which arose in the field since 2006, and to illustrate state-of-the-art techniques using a real-world satellite structure. Finally, a broader perspective to nonlinear system identification is provided by discussing the central role played by experimental models in the design cycle of engineering structures. [less ▲]

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See detailThe Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission.
Zeippen, Caroline ULiege; Javaux, Justine; Xiao, Xue ULiege et al

in Journal of Virology (2017), 91(13),

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a ... [more ▼]

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and in vitro, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection but is poorly released from vaginal epithelial cells and fails to pass from the female to the male genital tract during sexual contact. Thus, we show that the regulation of virion binding is a key component of spontaneous gammaherpesvirus transmission.IMPORTANCE Gammaherpesviruses are responsible for many important diseases in both animals and humans. Some important aspects of their life cycle are still poorly understood. Key among these is viral transmission. Here we show that the major envelope glycoprotein of murid herpesvirus 4 functions not in entry or dissemination but in virion release to allow sexual transmission to new hosts. [less ▲]

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See detailThiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels
Vignisse, Julie ULiege; Sambon, Margaux ULiege; Gorlova, Anna et al

in Molecular and Cellular Neuroscience (2017), 82

Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors ... [more ▼]

Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors with increased bioavailability, especially benfotiamine, exert neuroprotective effects not only for thiamine deficiency (TD), but also in mouse models of neurodegeneration. As it is known that AHN is impaired by stress in rodents, we exposed C57BL6/J mice to predator stress for 5 consecutive nights and studied the proliferation (number of Ki67-positive cells) and survival (number of BrdU-positive cells) of newborn immature neurons in the subgranular zone of the dentate gyrus. In stressed mice, the number of Ki67- and BrdU-positive cells was reduced compared to non-stressed animals. This reduction was prevented when the mice were treated (200 mg/kg/day in drinking water for 20 days) with thiamine or benfotiamine, that were recently found to prevent stress-induced behavioral changes and glycogen synthase kinase-3β (GSK-3β) upregulation in the CNS. Moreover, we show that thiamine and benfotiamine counteract stress-induced bodyweight loss and suppress stress-induced anxiety-like behavior. Both treatments induced a modest increase in the brain content of free thiamine while the level of thiamine diphosphate (ThDP) remained unchanged, suggesting that the beneficial effects observed are not linked to the role of this coenzyme in energy metabolism. Predator stress increased hippocampal protein carbonylation, an indicator of oxidative stress. This effect was antagonized by both thiamine and benfotiamine. Moreover, using cultured mouse neuroblastoma cells, we show that in particular benfotiamine protects against paraquat-induced oxidative stress. We therefore hypothesize that thiamine compounds may act by boosting anti-oxidant cellular defenses, by a mechanism that still remains to be unveiled. Our study demonstrates, for the first time, that thiamine and benfotiamine prevent stress-induced inhibition of hippocampal neurogenesis and accompanying physiological changes. The present data suggest that thiamine precursors with high bioavailability might be useful as a complementary therapy in several neuropsychiatric disorders. [less ▲]

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See detailGuest Editorial : New European Union plant health regime: A more stringent regulation that could impact trade from developing countries in the near future
Schiffers, Bruno ULiege

in Tunisian Journal of Plant Protection (2017), 12(1), 3

The new "Plant Health Law" provides more comprehensive and clearer rules for the prevention of entry into, and spread within, the EU territory of pests injurious to plant health but this regulation also ... [more ▼]

The new "Plant Health Law" provides more comprehensive and clearer rules for the prevention of entry into, and spread within, the EU territory of pests injurious to plant health but this regulation also includes regulating pests on the basis of pre-established criteria for risk assesment and prioritising of pests with the most serious consequences. [less ▲]

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See detailLaser optics in space failure risk due to laser induced contamination
Kokkinos, Dimitrios ULiege; Schroeder, Helmut; Fleury-Frenette, Karl ULiege et al

in CEAS Space Journal (2017), 8

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See detailImpaired bone formation in ovariectomized mice reduces implant integration as indicated by longitudinal in vivo micro-computed tomography
Li, Zihui; Kuhn, Gisela; Schirmer, Michael et al

in PLoS ONE (2017), 12(9), 1-22

Although osteoporotic bone, with low bone mass and deteriorated bone architecture, provides a less favorable mechanical environment than healthy bone for implant fixation, there is no general agreement on ... [more ▼]

Although osteoporotic bone, with low bone mass and deteriorated bone architecture, provides a less favorable mechanical environment than healthy bone for implant fixation, there is no general agreement on the impact of osteoporosis on peri-implant bone (re)modeling, which is ultimately responsible for the long term stability of the bone-implant system. Here, we inserted an implant in a mouse model mimicking estrogen deficiency-induced bone loss and we monitored with longitudinal in vivo micro-computed tomography the spatio-temporal changes in bone (re)modeling and architecture, considering the separate contributions of trabecular, endocortical and periosteal surfaces. Specifically, 12 week-old C57BL/6J mice underwent OVX/SHM surgery; 9 weeks after we inserted special metal-ceramics implants into the 6th caudal vertebra and we measured bone response with in vivo micro-CT weekly for the following 6 weeks. Our results indicated that ovariectomized mice showed a reduced ability to increase the thickness of the cortical shell close to the implant because of impaired peri-implant bone formation, especially at the periosteal surface. Moreover, we observed that healthy mice had a significantly higher loss of trabecular bone far from the implant than estrogen depleted animals. Such behavior suggests that, in healthy mice, the substantial increase in peri-implant bone formation which rapidly thickened the cortex to secure the implant may raise bone resorption elsewhere and, specifically, in the trabecular network of the same bone but far from the implant. Considering the already deteriorated bone structure of estrogen depleted mice, further bone loss seemed to be hindered. The obtained knowledge on the dynamic response of diseased bone following implant insertion should provide useful guidelines to develop advanced treatments for osteoporotic fracture fixation based on local and selective manipulation of bone turnover in the peri-implant region. [less ▲]

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See detailThe Lys-Asp-Tyr Triad within the Mite Allergen Der p 1 Propeptide Is a Critical Structural Element for the pH-Dependent Initiation of the Protease Maturation.
Chevigne, Andy; Campizi, Vincenzo; Szpakowska, Martyna et al

in International Journal of Molecular Sciences (2017), 18(5),

The major house dust mite allergen, Der p 1, is a papain-like cysteine protease expressed as an inactive precursor, proDer p 1, carrying an N-terminal propeptide with a unique structure. The maturation of ... [more ▼]

The major house dust mite allergen, Der p 1, is a papain-like cysteine protease expressed as an inactive precursor, proDer p 1, carrying an N-terminal propeptide with a unique structure. The maturation of the zymogen into an enzymatically-active form of Der p 1 is a multistep autocatalytic process initiated under acidic conditions through conformational changes of the propeptide, leading to the loss of its inhibitory ability and its subsequent gradual cleavage. The aims of this study were to characterize the residues present in the Der p 1 propeptide involved in the initiation of the zymogen maturation process, but also to assess the impact of acidic pH on the propeptide structure, the activity of Der p 1 and the fate of the propeptide. Using various complementary enzymatic and structural approaches, we demonstrated that a structural triad K17p-D51p-Y19p within the N-terminal domain of the propeptide is essential for its stabilization and the sensing of pH changes. Particularly, the protonation of D51p under acidic conditions unfolds the propeptide through disruption of the K17p-D51p salt bridge, reduces its inhibition capacity and unmasks the buried residues K17p and Y19p constituting the first maturation cleavage site of the zymogen. Our results also evidenced that this triad acts in a cooperative manner with other propeptide pH-responsive elements, including residues E56p and E80p, to promote the propeptide unfolding and/or to facilitate its proteolysis. Furthermore, we showed that acidic conditions modify Der p 1 proteolytic specificity and confirmed that the formation of the first intermediate represents the limiting step of the in vitro Der p 1 maturation process. Altogether, our results provide new insights into the early events of the mechanism of proDer p 1 maturation and identify a unique structural triad acting as a stabilizing and a pH-sensing regulatory element. [less ▲]

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See detailPreliminary JIRAM results from Juno polar observations: 3. Evidence of diffuse methane presence in the Jupiter auroral regions
Moriconi, M. L.; Adriani, A.; Dinelli, B. M. et al

in Geophysical Research Letters (2017), 44(10), 4641-4648

Throughout the first orbit of the NASA Juno mission around Jupiter, the Jupiter InfraRed Auroral Mapper (JIRAM) targeted the northern and southern polar regions several times. The analyses of the acquired ... [more ▼]

Throughout the first orbit of the NASA Juno mission around Jupiter, the Jupiter InfraRed Auroral Mapper (JIRAM) targeted the northern and southern polar regions several times. The analyses of the acquired images and spectra confirmed a significant presence of methane (CH4) near both poles through its 3.3 μm emission overlapping the H3 + auroral feature at 3.31 μm. Neither acetylene (C2H2) nor ethane (C2H6) have been observed so far. The analysis method, developed for the retrieval of H3 + temperature and abundances and applied to the JIRAM-measured spectra, has enabled an estimate of the effective temperature for methane peak emission and the distribution of its spectral contribution in the polar regions. The enhanced methane inside the auroral oval regions in the two hemispheres at different longitude suggests an excitation mechanism driven by energized particle precipitation from the magnetosphere. ©2017. American Geophysical Union. All Rights Reserved. [less ▲]

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See detailDeforestation drives functional diversity and fruit quality changes in a tropical tree assemblage
De Souza Pessoa, Michaele; Hambuckers, Alain ULiege; Benchimol, Maíra et al

in Perspectives in Plant Ecology, Evolution and Systematics (2017), 28C

Functional traits associated with plant-animal interactions are essential for forest functionality, given that a higher diversity of fruit traits is likely to maintain a more diverse assemblage of ... [more ▼]

Functional traits associated with plant-animal interactions are essential for forest functionality, given that a higher diversity of fruit traits is likely to maintain a more diverse assemblage of frugivores and consequently promote the seed dispersal function. Yet, shade-intolerant species tend to persist in human-modified landscapes in the long term, which in turn is expect to reduce fruit trait diversity. Here we evaluate how forest cover at the landscape-scale influences the functional diversity of fruit traits, considering the zoochoric tree community and two regeneration strategies separately (shade-tolerant and shade-intolerant species). We sampled 20 forest remnants in the Brazilian Atlantic Forest, located in landscapes with forest cover ranging from 2 to 93 %. In each remnant, we established five plots of 25 x 4 m and marked all trees ≥ 5 cm diameter at breast height (DBH). We compared morphological and chemical attributes of fleshy fruits directly related to the attraction of frugivores, and evaluated the similarity of the zoochoric tree assemblage composition along the forest cover gradient, taking into account the two regeneration strategies. We calculated four functional indices (richness, evenness, divergence, and community-level weighted means of trait values) and used either linear models or spatial mixed linear models to evaluate the effects of forest cover on functional diversity. Our main results revealed that forest cover loss has negatively affected fruit functional diversity for the overall zoochoric community. Forest cover loss also affected functional richness and functional eveness for total and shade-tolerant species, and was positively correlated with the content of protein and lipid in fruits of shade-intolerant species. Additionally, sites exhibiting a lower amount of forest cover showed greater compositional similarity among shade intolerant species but reduced similarity among shade-tolerant species. We conclude that patterns of species reassembly triggered by landscape-scale deforestation decreases the capacity of the remaining forest for provisioning food resources for frugivore assemblages. The maintenance of shade-tolerant species is pivotal in deforested areas, since their fruit quality is not offset by shade-intolerant species. This is particularly important, mainly because shade-intolerant species are those still persisting in disturbed forests; however, their presence will not provide the same food quality supplied by those species lost. [less ▲]

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See detailVIP: Vortex Image Processing package for high-contrast direct imaging
Gómez González, Carlos ULiege; Wertz, Olivier; Absil, Olivier ULiege et al

in Astronomical Journal (The) (2017)

We present the Vortex Image Processing (VIP) library, a python package dedicated to astronomical high-contrast imaging. Our package relies on the extensive python stack of scientific libraries and aims to ... [more ▼]

We present the Vortex Image Processing (VIP) library, a python package dedicated to astronomical high-contrast imaging. Our package relies on the extensive python stack of scientific libraries and aims to provide a flexible framework for high-contrast data and image processing. In this paper, we describe the capabilities of VIP related to processing image sequences acquired using the angular di↵erential imaging (ADI) observing technique. VIP implements functionalities for building high-contrast data processing pipelines, encompass- ing pre- and post-processing algorithms, potential sources position and flux estimation, and sensitivity curves generation. Among the reference point-spread function subtraction techniques for ADI post-processing, VIP includes several flavors of principal component analysis (PCA) based algorithms, such as annular PCA and incremental PCA algorithm capable of processing big datacubes (of several gigabytes) on a computer with limited memory. Also, we present a novel ADI algorithm based on non-negative matrix factorization (NMF), which comes from the same family of low-rank matrix approximations as PCA and provides fairly similar results. We showcase the ADI capabilities of the VIP library using a deep sequence on HR8799 taken with the LBTI/LMIRCam and its recently commissioned L-band vortex coronagraph. Using VIP we investigated the presence of additional companions around HR8799 and did not find any significant additional point source beyond the four known planets. VIP is available at http://github.com/vortex-exoplanet/VIP and is accompanied with Jupyter notebook tutorials illustrating the main functionalities of the library. [less ▲]

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See detailThe jotunites of the Korosten AMCG complex (Ukrainian shield): Crust or mantle-derived?
Duchesne, Jean-Clair ULiege; Schumlyanaskyy, Leonid; Mytrokhyn, Oleksandr

in Precambrian Research (2017), 299

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See detailDeceased organ donors with central nervous system neoplasm.
DETRY, Olivier ULiege

in Clinical Transplantation (2017)

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