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See detailDiet effects on bumblebee health
Roger, N.; Michez, D.; Wattiez, R. et al

in Journal of Insect Physiology (2017), 96

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as ... [more ▼]

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as the ability of an organism to mount an immune response, either in cellular, humoral or behavioural forms. In insects, immune capacity can be affected by a variety of factors including pesticides, genetic diversity or diet. Here we focus on an important species of domesticated pollinator, Bombus terrestris, and the potential impact of a poor pollen diet (low nutritional content and toxic) on its health. We investigate three responses at both colony and individual levels: behavioural, humoral and cellular. Our results show that poor pollen diets decrease larval and pupal masses and increase larval ejection as well as adult constitutive immunity (i.e., prophenoloxidase assays). The susceptibility of bumblebees to disease and infection might therefore be greater after a nutritive stress. These findings raise the importance of available plant hosts, especially floral plant species providing pollen with suitable nutritive quality (i.e., nutrient pollen content) for bumblebees. © 2016 Elsevier Ltd [less ▲]

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See detailRhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota.
Neyrinck, Audrey M.; Etxeberria, Usune; Taminiau, Bernard ULg et al

in Molecular Nutrition & Food Research (2017), 61(1), 1500899

SCOPE: Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by inflammation and oxidative stress, which could be promoted by gut barrier function ... [more ▼]

SCOPE: Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by inflammation and oxidative stress, which could be promoted by gut barrier function alterations. In this study, we have tested the hypothesis of the hepatoprotective effect of rhubarb extract in a mouse model of binge drinking and we explored the contribution of the gut microbiota in the related- metabolic effects. METHODS AND RESULTS: Mice were fed a control diet supplemented with or without 0.3% rhubarb extract for 17 days and were necropsied 6 hours after an alcohol challenge. Supplementation with rhubarb extract changed the microbial ecosystem (assessed by 16S rDNA pyrosequencing) in favor of Akkermansia muciniphila and Parabacteroides goldsteinii. Furthermore, it improved alcohol-induced hepatic injury, down-regulated key markers of both inflammatory and oxidative stresses in the liver tissue, without affecting significantly steatosis. In the gut, rhubarb supplementation increased crypt depth, tissue weight, the expression of antimicrobial peptides. CONCLUSIONS: These findings suggest that some bacterial genders involved in gut barrier function, are promoted by phytochemicals present in rhubarb extract, and could therefore be involved in the modulation of the susceptibility to hepatic diseases linked to acute alcohol consumption. This article is protected by copyright. All rights reserved. [less ▲]

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See detailEchocardiographic reference ranges for normal left ventricular 2D strain: results from the EACVI NORRE study
Sugimoto, T; DULGHERU, Raluca Elena ULg; BERNARD, Anne-Catherine ULg et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A ... [more ▼]

Aims To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean were −16.7% in men and −17.8% in women for longitudinal strain, −22.3% and −23.6% for circumferential strain, 20.6% and 21.5% for radial strain, and 2.2 degrees and 1.9 degrees for twist, respectively. In multivariable analysis, longitudinal strain decreased with age whereas the opposite occurred with circumferential and radial strain. Male gender was associated with lower strain for longitudinal, circumferential, and radial strain. Inter-vendor differences were observed for circumferential and radial strain despite the use of vendor-independent software. Importantly, no intervendor differences were noted in longitudinal strain. Conclusion The NORRE study provides contemporary, applicable 2D echocardiographic reference ranges for LV longitudinal, radial, and circumferential strain. Our data highlight the importance of age- and gender-specific reference values for LV strain. [less ▲]

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See detailSerum albumin level and hospital mortality in acute non-ischemic heart failure.
ANCION, Arnaud ULg; Allepaerts, Sophie; Oury, Cécile ULg et al

in ESC heart failure (2017), 4(2), 138-145

AIMS: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of ... [more ▼]

AIMS: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of hospital mortality in patients admitted for acute non-ischemic HF. METHODS AND RESULTS: We examined the association between albumin and hospital mortality in a cohort of 546 patients admitted for acute non-ischemic HF. None of the patients had infectious disease, severe arrhythmias (atrial fibrillation, ventricular tachycardia, ventricular fibrillation), required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Thirty-six patients (7%) died during the hospital stay. These patients were significantly older (78 +/- 9 vs. 72 +/- 12 years; P = 0.006), had higher heart rate (P < 0.0001), increased creatinine level (P = 0.01), lower systolic and diastolic blood pressures (P < 0.05), elevated leucocyte count (P = 0.001), and lower albumin levels (31.3 +/- 5.6 g/L vs. 36.9 +/- 4.1 g/L; P < 0.001). With multivariable analysis, age (P = 0.01), heart rate (P < 0.0003), diastolic blood pressure (P < 0.01), leukocyte count (P = 0.009), and serum albumin level (P < 0.0001) emerged as independent predictors of hospital mortality. Hypoalbuminemia (<34 g/L) yielded the best sensitivity (78.8%) and specificity (75%) for predicting hospital death. CONCLUSIONS: Serum albumin level measured at admission can serve as a simple prognostic factor in acute non-ischemic HF. Hypoalbuminemia is associated with increased risk of hospital mortality, especially in elderly patients. [less ▲]

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See detailThoracic endovascular aortic repair (TEVAR) in proximal (type A) aortic dissection: Ready for a broader application?
Nienaber, Christoph A.; Sakalihasan, Natzi ULg; Clough, Rachel E. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2017)

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role ... [more ▼]

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role in managing proximal aortic pathologies is unknown-this is important because in proximal (Stanford type A) aortic dissections, 10% to 30% are not accepted for surgery and 30% to 50% are technically amenable for TEVAR. We describe our case series of type A aortic dissections treated by using TEVAR. METHODS: Between year 2009 and 2016, 12 patients with acute, subacute, or chronic type A aortic dissection with the proximal entry tear located between the coronaries and brachiocephalic artery were treated with TEVAR at 3 centers. Various stent-graft configurations were used to seal the proximal entry tear in the ascending aorta under rapid pacing. RESULTS: A total of 12 patients (9 male, 3 female), mean age 81 +/- 7 years, EuroSCORE II 9.1 +/- 4.5, underwent TEVAR for the treatment of type A aortic dissection. Procedural success was achieved in 11 of 12 patients (91.7%). There was 1 minor stroke and 1 intraprocedural death. No additional deaths were reported at 30 days. At 36 months, there were 4 further deaths (all from nonaortic causes). The mean survival of these 4 deceased was 23 months (range 15-36 months). Follow-up computed tomography demonstrated favorable aortic remodeling. CONCLUSIONS: TEVAR is feasible and reveals promising early results in selected patients with type A aortic dissection who are poor candidates for surgical repair. The current iteration of stent-graft technology, however, needs to be adapted to features specific to the ascending aorta. [less ▲]

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See detailTopography and Lateralized Effect of Acute Aromatase Inhibition on Auditory Processing in a Seasonal Songbird
de groof, Geert; Balthazart, Jacques ULg; Cornil, Charlotte ULg et al

in Journal of Neuroscience (2017), 37(16), 4243-4254

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of ... [more ▼]

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of estrogens on nuclear receptors. One of the best examples of such neuro- modulation by neuroestrogens concerns the acute regulation of sensory coding by the auditory cortex as demonstrated by electrophys- iological studies of selected neurons in zebra finches. Yet, the spatial extent of such modulation by neuroestrogens is not known. Using functional magnetic resonance imaging, we demonstrate here that acute estrogen depletion alters within minutes auditory processing in male European starlings. These effects are confined to very specific but large areas of the auditory cortex. They are also specifically lateralized to the left hemisphere. Interestingly, the modulation of auditory responses by estrogens was much larger (both in amplitude and in topography) in March than in December or May/June. This effect was presumably independent from changes in circulating testosterone concentrations since levels of the steroid were controlled by subcutaneous implants, thus suggesting actions related to other aspects of the seasonal cycle or photoperiodic manipulations. Finally, we also show that estrogen production specifically modulates selectivity for behaviorally relevant vocalizations in a specific part of the caudomedial nidopallium. These findings confirm and extend previous conclusions that had been obtained by electrophysiological techniques. This approach provides a new very powerful tool to investigate auditory responsiveness in songbirds and its fast modulation by sex steroids. [less ▲]

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See detailContinuous variables logic via coupled automata using a DNAzyme cascade with feedback
Lilienthal, Sivan; Orbach, Ron; Willner, Itamar et al

in Chemical Science (2017), 8

The concentration of molecules can be changed by chemical reactions and thereby offer a continuous readout. Yet computer architecture is cast in textbooks in terms of binary valued, Boolean variables. To ... [more ▼]

The concentration of molecules can be changed by chemical reactions and thereby offer a continuous readout. Yet computer architecture is cast in textbooks in terms of binary valued, Boolean variables. To enable reactive chemical systems to compute we show how, using the Cox interpretation of probability theory, one can transcribe the equations of chemical kinetics as a sequence of coupled logic gates operating on continuous variables. It is discussed how the distinct chemical identity of a molecule allows us to create a common language for chemical kinetics and Boolean logic. Specifically, the logic AND operation is shown to be equivalent to a bimolecular process. The logic XOR operation represents chemical processes that take place concurrently. The values of the rate constants enter the logic scheme as inputs. By designing a reaction scheme with a feedback we endow the logic gates with a built in memory because their output then depends on the input and also on the present state of the system. Technically such a logic machine is an automaton. We report an experimental realization of three such coupled automata using a DNAzyme multilayer signaling cascade. A simple model verifies analytically that our experimental scheme provides an integrator generating a power series that is third order in time. The model identifies two parameters that govern the kinetics and shows how the initial concentrations of the substrates are the coefficients in the power series. [less ▲]

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See detailOn the evaluation of interface quality in concrete repair system by means of impact-echo signal analysis
Garbacz, Andrzej; Piotrowski, Tomacz; Courard, Luc ULg et al

in Construction and Building Materials (2017), 134

According to Concrete Repair Manual as well as ACI 562-16 and European EN 1504-10 standards, a bond strength as a measure of adhesion is one the main feature of repair system necessary to be assessed. The ... [more ▼]

According to Concrete Repair Manual as well as ACI 562-16 and European EN 1504-10 standards, a bond strength as a measure of adhesion is one the main feature of repair system necessary to be assessed. The most common laboratory and engineering method for bond strength evaluation is pull-off test. This is however a semi-destructive method that needs a repair in a place of measurement. Recently, the great interest in nondestructive techniques (NDT) development is noted. Impact-Echo (IE) is considered as one of the most promising methods for this purpose. In this paper, the study on the usability the IE test based on frequency spectrum analysis for bond strength evaluation is analyzed. Both Finite Element Method (FEM) simulation and experimental tests were performed in order to obtain potential relations between IE frequency spectrum and parameters characterizing concrete substrate quality that may affect the final bond strength and the real value of pull-off bond strength measured on samples as well. It was concluded that the IE method can be a useful tool for interface quality and bond strength evaluations in concrete repair system. However, more complex signal analysis, e.g. wavelet analysis, should be considered in the future. [less ▲]

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See detailPest and mould infestation of smoked shrimp and preventive measures for storage in cottage industry
Kpoclou; Anihouvi; Azokpota et al

in Indian Journal of Traditional Knowledge (2017), 16

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See detailIsotopic niches of Fin Whales from the Mediterranean Sea and the Celtic sea (North Atlantic)
Das, Krishna ULg; Holleville, Ophélie; Ryan, Conor et al

in Marine Environmental Research (2017), 127

The fin whale (Balaenoptera physalus) is the most abundant and widespread mysticete species in the Mediterranean Sea, found mostly over deep, offshore waters of the western and central portion of the ... [more ▼]

The fin whale (Balaenoptera physalus) is the most abundant and widespread mysticete species in the Mediterranean Sea, found mostly over deep, offshore waters of the western and central portion of the region. In the Mediterranean, this species is known to feed mainly on krill, in contrast to its Atlantic counterpart, which displays a more diversified diet. The International Whaling Commission recognizes several managements units in the Atlantic and the Mediterranean Sea and the connectivity between these populations is still being debated. Questions remain about inter-individual feeding strategies and trophic ecology. The goal of this study was to compare isotopic niches of fin whales from the Mediterranean Sea and the Celtic Sea (North Atlantic). δ13C and δ15N values were analysed in 136 skin biopsies from free-ranging Mediterranean fin whales sampled in 2010 and 2011 during campaigns at sea. δ13C and δ15N values ranged from -20.4 to -17.1 ‰ and from 5.9 to 8.9 ‰, respectively. These values are in good agreement with those estimated previously from baleen plates from Mediterranean and North Atlantic fin whales. The narrow isotopic niche width of the Mediterranean fin whale (Standard Ellipses area SEAc) compared to the North Atlantic fin whale raises many concerns in the context of global changes and long-term consequences. One could indeed expect that species displaying narrow niches would be more susceptible to ecosystem fragmentation and other anthropogenic impacts. [less ▲]

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See detailEstrogen receptors and estetroldependent neuroprotective actions: a pilot study
Tskitishvili, Ekaterine ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Journal of Endocrinology (2017), 232(1), 85-95

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen ... [more ▼]

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/proliferating effects of E4 on H2O2-induced oxidative stress in primary hippocampal cell cultures were studied using different combinations of specific inhibitors for ERalpha (MPP dihydrochloride), ERbeta (PHTTP), GPR30 (G15) and palmytoilation (2-BR). LDH activity and cell survival assays were performed. In vivo the promyelinating role of different concentrations of E4 (1 mg/kg/day, 5 mg/kg/day, 10 mg/kg/day, 50 mg/kg/day) was investigated using the hypoxic-ischemic brain damage model in the 7-day-old immature rats before/after the induction of hypoxic-ischemic insult. Myelin basic protein (MBP) immunostaining was performed on brain coronal sections. Our results show that LDH activity is significantly upregulated in cell cultures where the E4's effect was completely blocked by concomitant treatment either with ERalpha and ERbeta inhibitors (MPP and PHTPP, respectively), or ERalpha and ERbeta inhibitors combined with 2-BR. Cell survival is significantly downregulated in cell cultures where the effect of E4 was blocked by ERbeta inhibitor (PHTTP) alone. The blockage of GRP30 receptor did affect neither LDH activity nor cell survival. MBP immunostaining is significantly upregulated in E4-pretreated groups at a concentration of 5 mg/kg/day and 50 mg/kg/day E4, whereas the MBP-positive area OD ratio is significantly increased in all the E4-treated groups. E4's antioxidative actions mostly depend on ERalpha and ERbeta, whereas neurogenesis and possibly promyelinating activities might be realized through ERbeta. [less ▲]

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See detailIron-dependent nitrogen cycling in a ferruginous lake and the nutrient status of Proterozoic oceans
Michiels, Celine C.; Darchambeau, François ULg; Roland, Fleur ULg et al

in Nature Geoscience (2017), advance online publication

Nitrogen limitation during the Proterozoic has been inferred from the great expanse of ocean anoxia under low-O2 atmospheres, which could have promoted NO3- reduction to N2 and fixed N loss from the ocean ... [more ▼]

Nitrogen limitation during the Proterozoic has been inferred from the great expanse of ocean anoxia under low-O2 atmospheres, which could have promoted NO3- reduction to N2 and fixed N loss from the ocean. The deep oceans were Fe rich (ferruginous) during much of this time, yet the dynamics of N cycling under such conditions remain entirely conceptual, as analogue environments are rare today. Here we use incubation experiments to show that a modern ferruginous basin, Kabuno Bay in East Africa, supports high rates of NO3- reduction. Although 60 of this NO3- is reduced to N2 through canonical denitrification, a large fraction (40\%) is reduced to NH4+, leading to N retention rather than loss. We also find that NO3- reduction is Fe dependent, demonstrating that such reactions occur in natural ferruginous water columns. Numerical modelling of ferruginous upwelling systems, informed by our results from Kabuno Bay, demonstrates that NO3- reduction to NH4+ could have enhanced biological production, fuelling sulfate reduction and the development of mid-water euxinia overlying ferruginous deep oceans. This NO3- reduction to NH4+ could also have partly offset a negative feedback on biological production that accompanies oxygenation of the surface ocean. Our results indicate that N loss in ferruginous upwelling systems may not have kept pace with global N fixation at marine phosphorous concentrations (0.04-0.13[thinsp][mu]M) indicated by the rock record. We therefore suggest that global marine biological production under ferruginous ocean conditions in the Proterozoic eon may thus have been P not N limited. [less ▲]

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See detailDistances between nested densities and a measure of the impact of the prior in Bayesian statistics
Ley, Christophe; Reinert, Gesine; Swan, Yvik ULg

in Annals of Applied Probability (2017), 27(1), 216-241

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See detailMT4-MMP and EGFR expression levels are key biomarkers for breast cancer patient response to chemotherapy and erlotinib.
Yip, Cassandre ULg; Foidart, Pierre ULg; Somja, Joan ULg et al

in British Journal of Cancer (2017)

BACKGROUND: Triple-negative breast cancers (TNBC) are heterogeneous cancers with poor prognosis. We aimed to determine the clinical relevance of membrane type-4 matrix metalloproteinase (MT4-MMP), a ... [more ▼]

BACKGROUND: Triple-negative breast cancers (TNBC) are heterogeneous cancers with poor prognosis. We aimed to determine the clinical relevance of membrane type-4 matrix metalloproteinase (MT4-MMP), a membrane type matrix metalloproteinase that interacts with epidermal growth factor receptor (EGFR) overexpressed in >50% of TNBC. METHODS: We conducted a retrospective immunohistochemical analysis on human TNBC samples (n=81) and validated our findings in in vitro and in vivo assays. RESULTS: Membrane type-4 matrix metalloproteinase and EGFR are produced in 72.5% of TNBC samples, whereas those proteins are faintly produced by healthy tissues. Unexpectedly, tumour relapse after chemotherapy was reduced in samples highly positive for MT4-MMP. Mechanistically, this is ascribed to a higher sensitivity of MT4-MMP-producing cells to alkylating or intercalating chemotherapeutic agents, as assessed in vitro. In sharp contrast, MT4-MMP expression did not affect tumour cell sensitivity to paclitaxel that interferes with protease trafficking. Importantly, MT4-MMP expression sensitised cancer cells to erlotinib, a tyrosine kinase EGFR inhibitor. In a pre-clinical model, the growth of MT4-MMP overexpressing xenografts, but not of control ones, was reduced by epirubicin or erlotinib. The combination of suboptimal drug doses blocked drastically the growth of MT4-MMP-producing tumours. CONCLUSIONS: We demonstrate that MT4-MMP defines a sub-population of TNBC sensitive to a combination of DNA-targeting chemotherapeutic agents and anti-EGFR drugs.British Journal of Cancer advance online publication 14 February 2017; doi:10.1038/bjc.2017.23 www.bjcancer.com. [less ▲]

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See detailA generic wear prediction procedure based on the Discrete Element Method for ball mill liners in the cement industry
Boemer, Dominik ULg; Ponthot, Jean-Philippe ULg

in Minerals Engineering (2017)

generic procedure to predict the wear evolution of lining surfaces, namely the spatial distribution of wear and the progressive modification of the geometry due to wear, is introduced in the context of ... [more ▼]

generic procedure to predict the wear evolution of lining surfaces, namely the spatial distribution of wear and the progressive modification of the geometry due to wear, is introduced in the context of shell liners in ball mills. The wear data is accumulated on the surface of the liner by 3D discrete element method (DEM) simulations of the ball charge in an axial slice of the mill, which is either closed by a periodic boundary condition or by frictionless end walls. The calibration of this wear data with the measured wear profiles of the shell liner in a 5.8 m diameter industrial cement tube mill shows that the tangential damping energy defined by the linear spring-slider-damper DEM contact law is the best fitting wear model of 6 different models. The gradual update of the liner shape delivers adequate results for liners without an axial height variation, while the accuracy of fully variable geometrical modifications is limited by the computation time. Nevertheless, detailed phenomena, like the creation of grooves in the liner, were for the first time numerically modeled. [less ▲]

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See detailImpaired familiarity in individuals at risk for Alzheimer's disease: Commentary on Schoemaker et al. (2016)
Bastin, Christine ULg; Besson, Gabriel ULg

in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017), 6

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See detailStudy of the photocatalytic activity of Fe3+, Cr3+, La3+ and Eu3+ single-doped and co-doped TiO2 catalysts produced by aqueous sol-gel processing
Malengreaux, Charline; Pirard, Sophie ULg; Léonard, Géraldine ULg et al

in Journal of Alloys and Compounds (2017), 691

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination ... [more ▼]

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination step, has been adapted to produce Fe3+, Cr3+, La3+ or Eu3+ single-doped TiO2 photocatalysts as well as La3+-Fe3+ and Eu3+-Fe3+ co-doped TiO2 catalysts. The physicochemical properties of the obtained catalysts have been characterized using a suite of complementary techniques, including ICP-AES, XRD, UV-Vis spectroscopy, nitrogen adsorption-desorption and Fe-57 Mössbauer. The active crystalline phase is obtained without requiring any calcination step and all the different catalysts are composed of nanocrystallites of anatase with a size of 6-7 nm and a high specific surface area varying from 181 to 298 m² g-1. In this study, the effect of the NO3:Ti(IV) mole ratio used to induce the peptisation reaction during the synthesis has been studied and the results revealed that this ratio can influence significantly the textural properties of the resulting catalyst. A screening of the photocatalytic activity of the undoped and Fe3+, Cr3+, La3+ or Eu3+ single-doped and co-doped photocatalysts has been performed by evaluating the degradation of 4-nitrophenol under UV-Visible light (330 nm < λ < 800 nm). This study suggests that the photocatalytic activity is significantly influenced by the dopant nature and content with an optimal dopant content being observed in the case of Fe3+ or La3+ single-doped as well as in the case of La3+-Fe3+ and Eu3+-Fe3+ co-doped catalysts. In the case of Cr3+ single-doped catalysts, a detrimental effect of the dopant on the photocatalytic degradation of 4-nitrophenol has been observed while no significant influence of the dopant has been detected in the case of Eu3+ single-doped catalysts. The role of the different dopants in modulating the photocatalytic activity is discussed. [less ▲]

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See detailDisease Note. First Report of Persimmon Cryptic Virus in Spain
Ruiz-Garcia, A-B; Chamberland, N.; Martinez, C. et al

in Journal of Plant Pathology [=JPP] (2017), 99(1),

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See detailIterated local search for the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in Networks (2017)

In this article an Iterated Local Search algorithm for the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints is presented. Axle weight limits impose a ... [more ▼]

In this article an Iterated Local Search algorithm for the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints is presented. Axle weight limits impose a great challenge for transportation companies. Yet, the literature on the incorporation of axle weight constraints in vehicle routing models is very scarce. The effect of introducing axle weight constraints in a CVRP on total routing cost is analyzed. Results show that integrating axle weight constraints does not lead to a large cost increase. However, not including axle weight constraints in the planning process may induce major axle weight violations. [less ▲]

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See detailSystématiser les associations. Le concept hjelmslévien de paradigme et son héritage greimassien
Badir, Sémir ULg; Cigana, Lorenzo ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017), 8

This paper aims to explore the notion of “paradigm” by following its development in the epistemology of linguistics and semiotics of the twentieth century through three landmarks: its first use within ... [more ▼]

This paper aims to explore the notion of “paradigm” by following its development in the epistemology of linguistics and semiotics of the twentieth century through three landmarks: its first use within linguistics, by Ferdinand de Saussure, its redefinition by Louis Hjelmslev, and its reinterpretation in textual semiotics by Algirdas J. Greimas. The concept of “paradigm” represents, more than others, the very target of structuralist theorisation. Marking the transition between openness and closeness of linguistic categories, it crystallises the structuralist ambition to bring the dynamic variability and richness of semiotic phenomena back to a closed, or at least stable, inventory of functional ground elements. [less ▲]

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See detailComplete spectral energy distribution of the hot, helium-rich white dwarf RX J0503.9-2854
Hoyer, D.; Rauch, T.; Werner, K. et al

in Astronomy and Astrophysics (2017), 598

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See detailRigid catheters reduced duration of less invasive surfactant therapy procedures in manikins.
RIGO, Vincent ULg; Debauche, Christian; Maton, Pierre et al

in Acta Paediatrica (2017)

Aim: Different catheters can be used for less invasive surfactant therapy (LIST): feeding tubes inserted with or without Magill forceps, different angiocatheters and centre specific devices, such as ... [more ▼]

Aim: Different catheters can be used for less invasive surfactant therapy (LIST): feeding tubes inserted with or without Magill forceps, different angiocatheters and centre specific devices, such as umbilical catheters affixed to a stylet. This study compared the effectiveness of LIST devices and endotracheal tubes (ETT). Methods: Video recordings of 20 neonatologists simulating different LIST techniques on two manikin heads were analysed. Procedural effectiveness was evaluated by the duration of procedures and failure rates. Ease of use was scored. Results: The median procedure time for the Neonatal Intubation Trainer was significantly longer with feeding tubes without Maggil forceps. For the more difficult ALS Baby Trainer, successful procedures lasted a median of 24 (17-32) seconds with ETT, 24 (15-36) seconds with stylet-guided catheters and 34 (27-46) seconds and 37 (29-42) seconds with 13cm and 30cm angiocatheters, respectively. Both methods using feeding tubes were statistically slower than ETT intubation, lasting 32 (25-44) seconds and 39 (27-95) seconds with or without Maggil forceps. Failure rates (7-20%) were no different between the LIST methods. Techniques using feeding tubes were rated as more difficult. Conclusion: Only rigid or stylet-guided catheters required tracheal catheterisation times similar to those of endotracheal intubation and neonatologists found them easier.  KEY NOTES • This manikin study used video recordings of 20 neonatologists to compare the effectiveness of devices for less invasive surfactant therapy (LIST) and endotracheal tubes. • The durations of tracheal catheterisation for LIST using rigid or stylet-guided catheters were no different from those obtained with endotracheal tubes, but feeding tubes with or without Maggil forceps required longer procedures. • Neonatologists found rigid or stylet-guided catheters easier to use. [less ▲]

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See detailNanomedicine as a potent strategy in melanoma tumor microenvironment
Pautu, Vincent ULg; Leonetti, Daniela; Lepeltier, Elise et al

in Pharmacological Research (2017)

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See detailFacies discrimination with electrical resistivity tomography using a probabilistic methodology: Effect of sensitivity and regularization
Hermans, Thomas ULg; Irving, James

in Near Surface Geophysics (2017), 15

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution ... [more ▼]

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution of facies. However, inverted ERT images tend to be grossly smoothed versions of reality because of the regularization of the inverse problem. In this study, we use a probabilistic methodology based upon co-located measurements to assess the utility of ERT to identify hydrofacies in alluvial aquifers. With this methodology, ERT images are interpreted in terms of the probability of belonging to pre-defined hydrofacies. We first analyze through a synthetic study the ability of ERT to discriminate between different facies. As ERT data suffer from a loss of sensitivity with depth, we find that low sensitivity regions are more affected by misclassification. To counteract this effect, we adapt the probabilistic framework to include the spatially varying data sensitivity. We then apply our learning to a field case. For the latter, we consider two different regularization procedures. In contrast to the data sensitivity which affects the facies probability to a limited amount, the regularization can affect the probability maps more considerably because it has a strong influence on the spatial distribution of inverted resistivity. We find that a regularization strategy based on the most realistic prior information tends to offer the most reliable discrimination of facies. Our results confirm the ability of ERT surveys, when properly designed, to detect facies variations in alluvial aquifers. The method can be easily extended to other contexts. [less ▲]

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See detailEvaluation of hazardous chemicals in edible insects and insect-based food intended for human consumption
Poma, G; Cuykx, M; Amato, E et al

in Food and Chemical Toxicology (2017), 100

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See detailThiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels
Vignisse, Julie ULg; Sambon, Margaux ULg; Gorlova, Anna et al

in Molecular and Cellular Neuroscience (2017), 82

Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors ... [more ▼]

Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors with increased bioavailability, especially benfotiamine, exert neuroprotective effects not only for thiamine deficiency (TD), but also in mouse models of neurodegeneration. As it is known that AHN is impaired by stress in rodents, we exposed C57BL6/J mice to predator stress for 5 consecutive nights and studied the proliferation (number of Ki67-positive cells) and survival (number of BrdU-positive cells) of newborn immature neurons in the subgranular zone of the dentate gyrus. In stressed mice, the number of Ki67- and BrdU-positive cells was reduced compared to non-stressed animals. This reduction was prevented when the mice were treated (200 mg/kg/day in drinking water for 20 days) with thiamine or benfotiamine, that were recently found to prevent stress-induced behavioral changes and glycogen synthase kinase-3β (GSK-3β) upregulation in the CNS. Moreover, we show that thiamine and benfotiamine counteract stress-induced bodyweight loss and suppress stress-induced anxiety-like behavior. Both treatments induced a modest increase in the brain content of free thiamine while the level of thiamine diphosphate (ThDP) remained unchanged, suggesting that the beneficial effects observed are not linked to the role of this coenzyme in energy metabolism. Predator stress increased hippocampal protein carbonylation, an indicator of oxidative stress. This effect was antagonized by both thiamine and benfotiamine. Moreover, using cultured mouse neuroblastoma cells, we show that in particular benfotiamine protects against paraquat-induced oxidative stress. We therefore hypothesize that thiamine compounds may act by boosting anti-oxidant cellular defenses, by a mechanism that still remains to be unveiled. Our study demonstrates, for the first time, that thiamine and benfotiamine prevent stress-induced inhibition of hippocampal neurogenesis and accompanying physiological changes. The present data suggest that thiamine precursors with high bioavailability might be useful as a complementary therapy in several neuropsychiatric disorders. [less ▲]

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See detailNeutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide.
Reber, Laurent L.; Gillis, Caitlin M.; Starkl, Philipp et al

in Journal of Experimental Medicine (2017), 214(5), 1249-1258

Neutrophils have crucial antimicrobial functions but are also thought to contribute to tissue injury upon exposure to bacterial products, such as lipopolysaccharide (LPS). To study the role of neutrophils ... [more ▼]

Neutrophils have crucial antimicrobial functions but are also thought to contribute to tissue injury upon exposure to bacterial products, such as lipopolysaccharide (LPS). To study the role of neutrophils in LPS-induced endotoxemia, we developed a new mouse model, PMNDTR mice, in which injection of diphtheria toxin induces selective neutrophil ablation. Using this model, we found, surprisingly, that neutrophils serve to protect the host from LPS-induced lethal inflammation. This protective role was observed in conventional and germ-free animal facilities, indicating that it does not depend on a particular microbiological environment. Blockade or genetic deletion of myeloperoxidase (MPO), a key neutrophil enzyme, significantly increased mortality after LPS challenge, and adoptive transfer experiments confirmed that neutrophil-derived MPO contributes importantly to protection from endotoxemia. Our findings imply that, in addition to their well-established antimicrobial properties, neutrophils can contribute to optimal host protection by limiting the extent of endotoxin-induced inflammation in an MPO-dependent manner. [less ▲]

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See detailSignificant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.
Duncan, Laramie; Yilmaz, Zeynep; Gaspar, Helena et al

in American Journal of Psychiatry (The) (2017)

OBJECTIVE: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. METHOD ... [more ▼]

OBJECTIVE: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. METHOD: Following uniform quality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression was used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based heritability [h2SNP]), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and 159 other phenotypes. RESULTS: Results were obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele frequencies >1% and imputation quality scores >0.6. The h2SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes. CONCLUSIONS: Anorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genome-wide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology. [less ▲]

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See detailFirst report of the bee louse Braula schmitzi (Diptera: Braulidae) in apiaries of the “Los Chillos” Valley, Province of Pichincha, Ecuador
Zapata-Carvajal, N; Cherrez-Neacato, A; Martin-Solano, S et al

in Journal of Apicultural Research (2017)

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See detailVaginocutaneous fistula and buttock abscess formation 7 years after polypropylene transobturator tape insertion.
ABDALLAH, Alain; NISOLLE, Michelle ULg; DE LANDSHEERE, Laurent ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2017), 46

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including ... [more ▼]

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including infections, abscess and fistula formation. Here we report a case of 57 year old female who presented with abscess and left vaginocutaneous buttock fistula 7 years after transobturator polypropelene tape insertion. Treatment included abscess drainage with dissection of the fistulous tract and removal of the left arm of the transobturator tape along with antibiotic coverage. Sinus drainage stopped after 3 days. Stress urinary incontinence didn't recur. Suspicion of fistula formation should rise in patients presenting with bothersome vaginal or cutaneous discharge after transobturator tape insertion. This case is particular since it describes a fistula complication with polypropelene tape which is unusual with this type of tapes. Treatment of such complication should always consist of surgical removal of the mesh to allow closure of the fistulous tract. [less ▲]

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See detailThe role of parental anxiety sensitivity and learning experiences in children's anxiety sensitivity.
Stassart, Céline ULg; Dardenne, Benoît ULg; Etienne, Anne-Marie ULg

in British Journal of Developmental Psychology (2017)

This study evaluated the impact of the mother’s and father’s anxiety sensitivity (AS) andlearning experiences on children’s AS, and the influence of two moderators: the children’sfemininity orientation and ... [more ▼]

This study evaluated the impact of the mother’s and father’s anxiety sensitivity (AS) andlearning experiences on children’s AS, and the influence of two moderators: the children’sfemininity orientation and the children’s emotional intelligence (EI). The samplecomprised 200 non-clinical children, aged 9–13 years, and their parents (mothers andfathers). Results revealed that the effect of parental AS on children’s AS is moderated bythe children’s EI for maternal AS and by their femininity traits for paternal AS. Learningexperiences following somatic sensations influenced the children’s level of AS. Morespecifically, special attention by parents following a child’s somatic sensations (reinforce-ment and transmission of information) was associated with high AS in children. Parentalreactions of fear following a parent’s somatic sensations (modelling) seem to predicthigher scores for AS when the link is moderated by the child’s femininity orientation. Theimplications of these findings are discussed. [less ▲]

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See detailThiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stressinduced behaviours in mice
Markova, Nataliia; Bazhenova, Nataliya; Anthony, Daniel C et al

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (2017), 75

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling ... [more ▼]

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling the activities of glycogen synthase kinase (GSK)-3β. While decreased GSK- 3β activity appears to impair memory, increased GSK-3β activity is associated with the distressed/depressed state. However, direct evidence for the effects of thiamine on GSK-3β function were not have not been reported. Here, we administered thiamine or, the more bioavailable precursor, benfotiamine at 200 mg/kg/day for 2 weeks to C57BL/6J mice, to determine whether treatment might affect behaviours that are known to be sensitive to GSK-3β activity and whether such administration impacts on GSK-3β expression within the brain. The mice were tested in models of contextual conditioning and extinction, a 5-day rat exposure stress test, and a modified swim test with repeated testing. Imipramine (7.5 mg/kg/day) was administered as a positive control for thiamine or benfotiamine. As for imipramine, both compounds inhibited the upregulation of GSK-3β induced by predator stress or repeated swimming, and reduced floating scores and the predator stress-induced behavioural changes in anxiety and exploration. Coincident, thiamine and benfotiamine improved learning and extinction of contextual fear, and the acquisition of the step-down avoidance task. Together, our data indicate that thiamine and benfotiamine have antidepressant/anti-stress effects in naïve animals that are associated with reduced GSK-3β expression. Importantly, the treatment also had pro-cognitive actions despite the impact on GSK-3β activity. [less ▲]

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See detailEmbedded solids of any dimension in the X-FEM. Part I - Building a dedicated P1 function space
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape ... [more ▼]

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape functions, it introduces an algorithm to reduce the function space into an equivalent space having the same properties than a P1 Lagrange approximation. Convergence studies involving problems of codimension one or two embedded in 2D or 3D show good accuracy with regard to classical finite element and analytical solutions. The effects of the relative position of the domain with respect to the mesh are studied in a sensitivity analysis; it illustrates how the proposed solution allows to keep the condition number bounded. A comparative study is performed with the method introduced by Olshanskii et al. 2009 on a closed surface to validate our approach. The robustness of the proposed approach is investigated with regard to their method and that of Burman et al. 2016. This paper is the first in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. It investigates problems involving borderless domains or domains with boundary subject to Dirichlet constraint defined only on the boundaries of the bulk mesh, while the forthcoming paper overcomes this limitation by introducing a new stable Lagrange multiplier space for Dirichlet boundary condition (and more generally stiff condition), that is valid for every combination of the background mesh and manifold dimensions. The combination of both algorithms allows to handle any embedding i.e. 1D, 2D and 3D problems embedded in 2D or 3D background meshes. [less ▲]

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See detailConserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-alpha Receptor Delays Behavioral Fever in Fish.
Rakus, Krzysztof; Ronsmans, Maygane; Forlenza, Maria et al

in Cell Host & Microbe (2017), 21(2), 244-253

Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term "behavioral fever." We studied the ... [more ▼]

Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term "behavioral fever." We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24 degrees C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24 degrees C-32 degrees C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-alpha, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-alpha neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness. [less ▲]

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See detailThe frequency and influence of dementia risk factors in prodromal Alzheimer’s disease
Bos, Isabelle; Vos, Stephanie J.; Frölich, Lutz et al

in Neurobiology of Aging (2017), 56

We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association ... [more ▼]

We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association criteria, and with cognitive decline. 1394 subjects from with Mild Cognitive Impairment (MCI) from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of ten risk factors between the subgroups and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared to those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with MCI. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e. preclinical) of AD. [less ▲]

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See detailExposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Sabatel, Catherine ULg; Radermecker, Coraline ULg; Fievez, Laurence ULg et al

in Immunity (2017), 46(3), 457-473

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major ... [more ▼]

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow. Using a mouse model of allergic airway inflammation, we found that adoptive transfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. IM-mediated protection was dependent on IL-10, given that Il10-/- CpG-induced IMs lacked regulatory effects. Thus, the expansion of regulatory lung IMs upon exposure to CpG might underlie the reduced risk of asthma development associated with a microbe-rich environment. [less ▲]

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See detailAssessing cultivar resistance to Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae) using a phenotyping method under semi-field conditions
Chavalle, Sandrine ULg; Jacquemin, Guillaume; De Proft, Michel

in Journal of Applied Entomology (2017)

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin), can significantly reduce wheat yield. Growing resistant wheat cultivars is an effective way of managing this pest. The assessment of ... [more ▼]

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin), can significantly reduce wheat yield. Growing resistant wheat cultivars is an effective way of managing this pest. The assessment of cultivar resistance in field trials is difficult because of unequal pressure of S. mosellana caused by differences in cultivar heading dates relative to the flight period of S. mosellana adult females and huge variations of egg laying conditions from 1 day to another. To overcome these hurdles and to expose all cultivars homogeneously to the pest, an assessment method of cultivar resistance was developed under semi-field conditions. In 2015, the resistance of 64 winter wheat cultivars to S. mosellana was assessed. Few or no larvae developed in the ears of resistant cultivars, but in susceptible cultivars, large numbers of larvae developed. Seventeen cultivars proved to be resistant, whereas 47 were susceptible. The identification of new resistant cultivars offers more opportunities to manage S. mosellana. The phenotyping method is easy, cheap, efficient and reliable. It can be used to guide the breeding of new resistant wheat cultivars. Using specific midge populations, this method could also be used in research on new resistance mechanisms in winter wheat or in other cereal species. [less ▲]

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See detailA Belgian survey on the diagnosis of asthma-COPD overlap syndrome.
Cataldo, Didier ULg; Corhay, Jean-Louis ULg; Derom, Eric et al

in International Journal of Chronic Obstructive Pulmonary Disease (2017), 12

INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse ... [more ▼]

INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse and inconsistent. This survey aimed to identify consensus on criteria for diagnosing ACOS. METHODS: A Belgian expert panel developed a survey on ACOS diagnosis, which was completed by 87 pulmonologists. Answers chosen by >/=70% of survey respondents were considered as useful criteria for ACOS diagnosis. The two most frequently selected answers were considered as major criteria, others as minor criteria. The expert panel proposed a minimal requirement of two major criteria and one minor criterion for ACOS diagnosis. Respondents were also asked which criteria are important for considering inhaled corticosteroids prescription in a COPD patient. RESULTS: To diagnose ACOS in COPD patients, major criteria were "high degree of variability in airway obstruction over time (change in forced expiratory volume in 1 second >/=400 mL)" and "high degree of response to bronchodilators (>200 mL and >/=12% predicted above baseline)". Minor criteria were "personal/family history of atopy and/or IgE sensitivity to >/=1 airborne allergen", "elevated blood/sputum eosinophil levels and/or increased fractional exhaled nitric oxide", "diagnosis of asthma <40 years of age"; "symptom variability", and "age (in favor of asthma)". To diagnose ACOS in asthma patients, major criteria were "persistence of airflow obstruction over time (forced expiratory volume in 1 second/forced vital capacity ratio <0.7)" and "exposure to noxious particles/gases, with >/=10 pack-years for (ex-)smokers"; minor criteria were "lack of response on acute bronchodilator test"; "reduced diffusion capacity"; "limited variability in airway obstruction"; "age >40 years"; "emphysema on chest computed tomography scan". CONCLUSION: Specific criteria were identified that may guide physicians to a more uniform diagnostic approach for ACOS in COPD or asthma patients. These criteria are largely similar to those used to prescribe inhaled corticosteroids in COPD. [less ▲]

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See detailLooking for a Dialogue between Farmers and Scientific Soil Knowledge: Learnings from an Ethno-Geomorphopedological Study in a Philippine’s Upland Village
Richelle, Lola; Visser, Marjolein; Bock, Laurent ULg et al

in Agroecology and Sustainable Food Systems (2017), 0(ja),

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See detailQue peut la doctrine en droit des sociétés (et ailleurs)?
Thirion, Nicolas ULg

in Revue Pratique des Sociétés - Tijdschrift voor Rechtspersoon en Vennootschap (2017), 1

A quelle condition la doctrine peut-elle relever d'une démarche proprement scientifique? Telle est la question qu'abord cet éditorial.

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See detailVignette therapeutique de l'etudiant. Optimisation d'un traitement par insuline basale chez le patient diabetique de type 2.
Scheen, André ULg; Paquot, Nicolas ULg

in Revue Médicale de Liège (2017), 72(3), 156-161

Because of the natural history of type 2 diabetes and the increasing life expectancy, more and more patients are treated with insulin after failure of oral therapy. International guidelines give the ... [more ▼]

Because of the natural history of type 2 diabetes and the increasing life expectancy, more and more patients are treated with insulin after failure of oral therapy. International guidelines give the preference to basal insulin, most often while maintaining metformin. If this treatment does not allow to reach the glycaemic objectives, optimizing therapy is mandatory. This clinical case offers the opportunity of discussing both advantages and disadvantages of three therapeutic options : the shift from basal insulin to a basal-plus or a basal-bolus insulin regimen, the addition of another oral glucose-lowering agent, either a dipeptidyl peptidase-4 inhibitor (gliptin) or an inhibitor of cotransporters sodium-glucose type 2 cotransporters (gliflozin), or the combination of basal insulin and a glucagon-like peptide-1 receptor agonist. [less ▲]

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See detailCRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens
Collonnier, Cécile; Epert, Aline; Mara, Kostlend et al

in Plant Biotechnology Journal (2017), 15

The ability to address the CRISPR-Cas9 nuclease complex to any target DNA using customizable single-guide RNAs has now permitted genome engineering in many species. Here, we report its first successful ... [more ▼]

The ability to address the CRISPR-Cas9 nuclease complex to any target DNA using customizable single-guide RNAs has now permitted genome engineering in many species. Here, we report its first successful use in a nonvascular plant, the moss Physcomitrella patens. Single-guide RNAs (sgRNAs) were designed to target an endogenous reporter gene, PpAPT, whose inactivation confers resistance to 2-fluoroadenine. Transformation of moss protoplasts with these sgRNAs and the Cas9 coding sequence from Streptococcus pyogenes triggered mutagenesis at the PpAPT target in about 2% of the regenerated plants. Mainly, deletions were observed, most of them resulting from alternative end-joining (alt-EJ)-driven repair. We further demonstrate that, in the presence of a donor DNA sharing sequence homology with the PpAPT gene, most transgene integration events occur by homology-driven repair (HDR) at the target locus but also that Cas9- induced double-strand breaks are repaired with almost equal frequencies by mutagenic illegitimate recombination. Finally, we establish that a significant fraction of HDR-mediated gene targeting events (30%) is still possible in the absence of PpRAD51 protein, indicating that CRISPR-induced HDR is only partially mediated by the classical homologous recombination pathway. [less ▲]

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See detailProtean proteases: at the cutting edge of lung diseases.
Taggart, Clifford; Mall, Marcus A.; Lalmanach, Gilles et al

in European Respiratory Journal (2017), 49(2),

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and ... [more ▼]

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and it is now evident that proteases are critical pleiotropic actors orchestrating pathophysiological processes. Recent findings evidenced that the net proteolytic activity also relies upon interconnections between different protease and protease inhibitor families in the protease web.In this review, we provide an overview of these novel concepts with a particular focus on pulmonary pathophysiology. We describe the emerging roles of several protease families including cysteine and serine proteases.The complexity of the protease web is exemplified in the light of multidimensional regulation of serine protease activity by matrix metalloproteases through cognate serine protease inhibitor processing. Finally, we will highlight how deregulated protease activity during pulmonary pathogenesis may be exploited for diagnosis/prognosis purposes, and utilised as a therapeutic tool using nanotechnologies.Considering proteases as part of an integrative biology perspective may pave the way for the development of new therapeutic targets to treat pulmonary diseases related to intrinsic protease deregulation. [less ▲]

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See detailA polarimetric investigation of Jupiter: Disk-resolved imaging polarimetry and spectropolarimetry
McLean, W.; Stam, D. M.; Bagnulo, S. et al

in Astronomy and Astrophysics (2017), 601

Context. Polarimetry is a powerful remote sensing tool to characterise solar system planets and, potentially, to detect and characterise exoplanets. The linear polarisation of a planet as a function of ... [more ▼]

Context. Polarimetry is a powerful remote sensing tool to characterise solar system planets and, potentially, to detect and characterise exoplanets. The linear polarisation of a planet as a function of wavelength and phase angle is sensitive to the cloud and haze particle properties in planetary atmospheres, as well as to their altitudes and optical thicknesses. Aims. We present for the first time polarimetric signals of Jupiter mapped over the entire disk, showing features such as contrasts between the belts and zones, the polar regions, and the Great Red Spot. We investigate the use of these maps for atmospheric characterisation and discuss the potential application of polarimetry to the study of the atmospheres of exoplanets. Methods. We have obtained polarimetric images of Jupiter, in the B, V, and R filters, over a phase angle range of α = 4°–10.5°. In addition, we have obtained two spectropolarimetric datasets, over the wavelength range 500–850 nm. An atmospheric model was sought for all of the datasets, which was consistent with the observed behaviour over the wavelength and phase angle range. Results. The polarimetric maps show clear latitudinal structure, with increasing polarisation towards the polar regions, in all filters. The spectropolarimetric datasets show a decrease in polarisation as a function of wavelength along with changes in the polarisation in methane absorption bands. A model fit was achieved by varying the cloud height and haze optical thickness; this can roughly produce the variation across latitude for the V and R filters, but not for the B filter data. The same model particles are also able to produce a close fit to the spectropolarimetric data. The atmosphere of Jupiter is known to be complex in structure, and data taken at intermediate phase angles (unreachable for Earth-based telescopes) seems essential for a complete characterisation of the atmospheric constituents. Because exoplanets orbit other stars, they are observable at intermediate phase angles and thus promise to be better targets for Earth-based polarimetry. [less ▲]

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See detailParasitisme d’Apis mellifera adansonii (Latreille 1804) et de Meliponula bocandei (Spinola 1853) par Aethina tumida (Murray 1867): premier recensement au Gabon et impact sur la domestication
Fabre Anguilet, Edgard ULg; Alabi, Taofic ULg; Haubruge, Eric ULg et al

in Entomologie Faunistique = Faunistic Entomology (2017), 70

The small hive beetle, Aethina tumida (Murray 1867), has been reported in many countries in sub-Saharan Africa. This parasite is considered as a minor threat to strong Apis mellifera (Linnaeus 1758 ... [more ▼]

The small hive beetle, Aethina tumida (Murray 1867), has been reported in many countries in sub-Saharan Africa. This parasite is considered as a minor threat to strong Apis mellifera (Linnaeus 1758) colonies in Africa and as a major threat during the transfer of wild colonies of Meliponula bocandei (Spinola 1853) in hives. There is no data for Gabon and the state of wild colonies is still poorly known. Then, this study aims (1) to make a first prevalence assessment of A. tumida in wild colonies of A. mellifera and M. bocandei in Gabon; (2) to verify the effectiveness of quarantine implementation during the transfer of M. bocandei in hives against A. tumida. For that, 59 nests of A. mellifera and 25 nests of M. bocandei were inspected in two locations. Twelve nests of M. bocandei were transferred in hives with a quarantine for 4 days while 12 nests were transferred without quarantine. Aethina tumida was observed in more than 70 % of A. mellifera nests and in a single nest of M. bocandei. No damage was observed in nests of A. mellifera. More than 60 % of brood sections in quarantine or not were destroyed by A. tumida in hives. This study provided first evidence of the presence of A. tumida in Gabon and the need to develop a more effective method to domesticate M. bocandei in hives. [less ▲]

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See detailThe global burden of chronic kidney disease: estimates, variability and pitfalls.
Glassock, RJ; Warnock, DG; DELANAYE, Pierre ULg

in Nature Reviews Nephrology (2017), 13(2), 104-114

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See detailAnalogical reasoning in children with specific language impairment: Evidence from a scene analogy task
Krzemien, Magali ULg; Jemel, Boutheina; Maillart, Christelle ULg

in Clinical Linguistics & Phonetics (2017)

Analogical reasoning is a human ability that maps systems of relations. It develops along with relational knowledge, working memory and executive functions such as inhibition. It also maintains a mutual ... [more ▼]

Analogical reasoning is a human ability that maps systems of relations. It develops along with relational knowledge, working memory and executive functions such as inhibition. It also maintains a mutual influence on language development. Some authors have taken a greater interest in the analogical reasoning ability of children with language disorders, specifically those with specific language impairment (SLI). These children apparently have weaker analogical reasoning abilities than their aged-matched peers without language disorders. Following cognitive theories of language acquisition, this deficit could be one of the causes of language disorders in SLI, especially those concerning productivity. To confirm this deficit and its link to language disorders, we use a scene analogy task to evaluate the analogical performance of SLI children and compare them to controls of the same age and linguistic abilities. Results show that children with SLI perform worse than age-matched peers, but similar to language-matched peers. They are more influenced by increased task difficulty. The association between language disorders and analogical reasoning in SLI can be confirmed. The hypothesis of limited processing capacity in SLI is also being considered. [less ▲]

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See detailUnraveling microbial ecology of industrial-scale Kombucha fermentations by metabarcoding and culture-based methods.
Coton, Monika; Pawtowski, Audrey; Taminiau, Bernard ULg et al

in FEMS Microbiology Ecology (2017), 93(5),

Kombucha, historically an Asian tea-based fermented drink, has recently become trendy in Western countries. Producers claim it bears health-enhancing properties that may come from the tea or metabolites ... [more ▼]

Kombucha, historically an Asian tea-based fermented drink, has recently become trendy in Western countries. Producers claim it bears health-enhancing properties that may come from the tea or metabolites produced by its microbiome. Despite its long history of production, microbial richness and dynamics have not been fully unraveled, especially at an industrial scale. Moreover, the impact of tea type (green or black) on microbial ecology was not studied. Here, we compared microbial communities from industrial-scale black and green tea fermentations, still traditionally carried out by a microbial biofilm, using culture-dependent and metabarcoding approaches. Dominant bacterial species belonged to Acetobacteraceae and to a lesser extent Lactobacteriaceae, while the main identified yeasts corresponded to Dekkera, Hanseniaspora and Zygosaccharomyces during all fermentations. Species richness decreased over the 8-day fermentation. Among acetic acid bacteria, Gluconacetobacter europaeus, Gluconobacter oxydans, G. saccharivorans and Acetobacter peroxydans emerged as dominant species. The main lactic acid bacteria, Oenococcus oeni, was strongly associated with green tea fermentations. Tea type did not influence yeast community, with Dekkera bruxellensis, D. anomala, Zygosaccharomyces bailii and Hanseniaspora valbyensis as most dominant. This study unraveled a distinctive core microbial community which is essential for fermentation control and could lead to Kombucha quality standardization. [less ▲]

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See detailMembrane Interactions of Natural Cyclic Lipodepsipeptides of the Viscosin Group
Geudens, Niels; Nasir, Mehmet Nail ULg; Crowet, Jean-Marc ULg et al

in Biochimica et Biophysica Acta - Biomembranes (2017), 1859(3), 331-339

Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It ... [more ▼]

Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It has been established that interaction with the cellular membrane is central to the mode of action of CLPs. In this work, we focus on the CLPs of the so-called viscosin group, aiming to assess the impact of the main structural variations observed within this group on both the antimicrobial activity and the interaction with model membranes. The antimicrobial activity of viscosin, viscosinamide A, WLIP and pseudodesmin A were all tested on a broad panel of mainly Gram-positive bacteria. Their capacity to permeabilize or fuse PG/PE/cardiolipin model membrane vesicles is assessed using fluorescent probes. We find that the Glu2/Gln2 structural variation within the viscosin group is the main factor that influences both the membrane permeabilization properties and the minimum inhibitory concentration of bacterial growth, while the configuration of the Leu5 residue has no apparent effect. The CLPmembrane interactions were further evaluated using CD and FT-IR spectroscopy on model membranes consisting of PG/PE/cardiolipin or POPC with or without cholesterol. In contrast to previous studies, we observe no conformational change upon membrane insertion. The CLPs interact both with the polar heads and aliphatic tails of model membrane systems, altering bilayer fluidity, while cholesterol reduces CLP insertion depth [less ▲]

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See detailMolecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525.
Bell, Erica Hlavin; Pugh, Stephanie L.; McElroy, Joseph P. et al

in JAMA Oncology (2017)

Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive ... [more ▼]

Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables. Design, Setting, and Participants: NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiquantitative immunohistochemical validation. Prognostic significance of each protein was examined by single-marker and multimarker Cox regression analyses. To reclassify the prognostic risk groups, significant protein biomarkers on single-marker analysis were incorporated into an RPA model consisting of the same clinical variables (age, Karnofsky Performance Status, extent of resection, and neurologic function) as the existing RTOG RPA. The new RPA model (NRG-GBM-RPA) was confirmed using traditional immunohistochemistry in an independent data set (n = 176). Main Outcomes and Measures: Overall survival (OS). Results: In 452 specimens, MGMT (hazard ratio [HR], 1.81; 95% CI, 1.37-2.39; P < .001), survivin (HR, 1.36; 95% CI, 1.04-1.76; P = .02), c-Met (HR, 1.53; 95% CI, 1.06-2.23; P = .02), pmTOR (HR, 0.76; 95% CI, 0.60-0.97; P = .03), and Ki-67 (HR, 1.40; 95% CI, 1.10-1.78; P = .007) protein levels were found to be significant on single-marker multivariate analysis of OS. To refine the existing RPA, significant protein biomarkers together with clinical variables (age, Karnofsky Performance Status, extent of resection, and neurological function) were incorporated into a new model. Of 166 patients used for the new NRG-GBM-RPA model, 97 (58.4%) were male (mean [SD] age, 55.7 [12.0] years). Higher MGMT protein level was significantly associated with decreased MGMT promoter methylation and vice versa (1425.1 for methylated vs 1828.0 for unmethylated; P < .001). Furthermore, MGMT protein expression (HR, 1.84; 95% CI, 1.38-2.43; P < .001) had greater prognostic value for OS compared with MGMT promoter methylation (HR, 1.77; 95% CI, 1.28-2.44; P < .001). The refined NRG-GBM-RPA consisting of MGMT protein, c-Met protein, and age revealed greater separation of OS prognostic classes compared with the existing clinically based RPA model and MGMT promoter methylation in NRG Oncology RTOG 0525. The prognostic significance of the NRG-GBM-RPA was subsequently confirmed in an independent data set (n = 176). Conclusions and Relevance: This new NRG-GBM-RPA model improves outcome stratification over both the current RTOG RPA model and MGMT promoter methylation, respectively, for patients with GBM treated with radiation and temozolomide and was biologically validated in an independent data set. The revised RPA has the potential to contribute to improving the accurate assessment of prognostic groups in patients with GBM treated with radiation and temozolomide and to influence clinical decision making. Trial Registration: clinicaltrials.gov Identifier: NCT00304031. [less ▲]

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See detailUsing a Structural Root System Model to Evaluate and Improve the Accuracy of Root Image Analysis Pipelines
Lobet, Guillaume; Koevoets, Iko; Noll, Manuel ULg et al

in Frontiers in Plant Science (2017), 8

Root system analysis is a complex task, often performed with fully automated image analysis pipelines. However, the outcome is rarely verified by ground-truth data, which might lead to underestimated ... [more ▼]

Root system analysis is a complex task, often performed with fully automated image analysis pipelines. However, the outcome is rarely verified by ground-truth data, which might lead to underestimated biases. We have used a root model, ArchiSimple, to create a large and diverse library of ground-truth root system images (10,000). For each image, three levels of noise were created. This library was used to evaluate the accuracy and usefulness of several image descriptors classically used in root image analysis softwares. Our analysis highlighted that the accuracy of the different traits is strongly dependent on the quality of the images and the type, size and complexity of the root systems analysed. Our study also demonstrated that machine learning algorithms can be trained on a synthetic library to improve the estimation of several root system traits. Overall, our analysis is a call to caution when using automatic root image analysis tools. If a thorough calibration is not performed on the dataset of interest, unexpected errors might arise, especially for large and complex root images. To facilitate such calibration, both the image library and the different codes used in the study have been made available to the community. [less ▲]

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See detailCan DEM time series produced by UAV be used to quantify diffuse erosion in an agricultural watershed?
Pineux, Nathalie ULg; Lisein, Jonathan ULg; Swerts, Gilles ULg et al

in Geomorphology (2017), 280

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion ... [more ▼]

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion monitoring approaches are labour intensive and costly. This calls for the development of new approaches for field erosion data acquisition. As a result of rapid technological developments and low cost, unmanned aerial vehicles (UAV) have recently become an attractive means of generating high resolution digital elevation models (DEMs). The use of UAV to observe and quantify gully erosion is now widely established. However, in some agro-pedological contexts, soil erosion results from multiple processes, including sheet and rill erosion, tillage erosion and erosion due to harvest of root crops. These diffuse erosion processes often represent a particular challenge because of the limited elevation changes they induce. In this study,we propose to assess the reliability and development perspectives of UAV to locate and quantify erosion and deposition in a context of an agricultural watershed with silt loam soils and a smooth relief. Erosion and deposition rates derived from high resolution DEM time series are compared to field measurements. The UAV technique demonstrates a high level of flexibility and can be used, for instance, after a major erosive event. It delivers a very high resolution DEM(pixel size: 6 cm) which allows us to compute high resolution runoff pathways. This could enable us to precisely locate runoff management practices such as fascines. Furthermore, the DEMs can be used diachronically to extract elevation differences before and after a strongly erosive rainfall and be validated by field measurements. While the analysis for this study was carried out over 2 years, we observed a tendency along the slope from erosion to deposition. Erosion and deposition patterns detected at the watershed scale are also promising. Nevertheless, further development in the processing workflow of UAV data is required in order to make this technique accurate and robust enough for detecting sediment movements in an agricultural watershed affected by diffuse erosion. This area of investigation holdsmuch potential as the images processing is relatively new and expanding. [less ▲]

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See detailCardiopulmonary exercise testing is a better outcome predictor than exercise echocardiography in asymptomatic aortic stenosis.
Domanski, Olivia; Richardson, Marjorie; Coisne, Augustin et al

in International Journal of Cardiology (2017), 227

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship ... [more ▼]

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship between peak VO2 and AS severity criteria derived from rest and supine exercise echocardiography (SEE) has never been explored. OBJECTIVES: We aimed to determine whether low peak VO2 (<85% of predicted value) is associated with severity parameters in SEE, and poor clinical outcome. METHODS: Fifty one asymptomatic patients (mean age of 54+/-21years) with moderate to severe aortic stenosis (Vmax>3m/s) and left ventricle ejection fraction>50% prospectively underwent resting and SEE and cardiopulmonary exercise testing (CPX). RESULTS: Peak VO2 was lower than expected (21.9+/-7.4mL/kg/min), i.e. <85% of predicted value in 57% patients, secondary to cardiac limitation in most of them (69%). In multiple regression analysis, age, BMI and female gender were the only independent determinants of peak VO2. Interestingly no parameter derived from SEE was associated with peak VO2. After 21+/-7month follow-up, no patient died, 20 underwent cardiac surgery. Peak VO2<85% of predicted value was associated with lower event free survival compared to normal peak VO2 (57%+/-11% vs 93+/-6%, p=0.036) whereas no exercise echocardiographic parameter could predict such events. Peak VO2>/=85% had a negative predictive value of 97%. CONCLUSION: CPX detects a high proportion of false asymptomatic AS patients with poorer outcome that cannot be predicted by SEE markers of AS severity. Assessment of aerobic capacity should be part of current approach within a "watchful waiting" strategy. [less ▲]

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See detailEffect of undisturbed ground temperature on the design of closed-loop geothermal systems: A case study in a semi-urban environment
Radioti, Georgia ULg; Sartor, Kevin ULg; Charlier, Robert ULg et al

in Applied Energy (2017)

This paper presents temperature measurements in four Borehole Heat Exchangers (BHEs), equipped with fiber optics and located in a semi-urban environment (campus of the University of Liege, Belgium). A 3D ... [more ▼]

This paper presents temperature measurements in four Borehole Heat Exchangers (BHEs), equipped with fiber optics and located in a semi-urban environment (campus of the University of Liege, Belgium). A 3D numerical model is also presented to simulate the heat loss from the surrounding structures into the subsurface. The mean undisturbed ground temperature was estimated from data during the preliminary phase of a thermal response test (water circulation in the pipe loops), as well as from borehole logging measurements. The measurements during water circulation can significantly overestimate the ground temperature (up to 1.7 C in this case study) for high ambient air temperature during the test, resulting in an overestimation of the maximum extracted power and of the heat pump coefficient of performance (COP). To limit the error in the COP and the extracted power to less than 5%, the error in the undisturbed temperature estimation should not exceed ±1.5 °C and ±0.6 °C respectively. In urbanised areas, configurations of short BHEs (length < 40 m) could be economically advantageous (decreased installation and operation costs) compared to long BHEs, especially for temperature gradient lower than 0.05 °C/m. [less ▲]

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See detailtRNA modification: is cancer having a wobble?
Rapino, Francesca ULg; Zhou, Zhaoli ULg; Delaunay, Sylvain et al

in Trends in Cancer (2017), 3

Translational control of protein synthesis supports tumor development and progression to metastasis. Wobble tRNA modifications are required during translation elongation and sustain proteome homeostasis ... [more ▼]

Translational control of protein synthesis supports tumor development and progression to metastasis. Wobble tRNA modifications are required during translation elongation and sustain proteome homeostasis. Recent work has highlighted the surprising upregulation of the wobble uridine 34 (U34) tRNA cascade in cancer, which underlies the specific requirement for this pathway in tumor development. [less ▲]

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See detailPerinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels: Gender selective effects
Soualed, Nidhal; Dridi, Imen; Eppe, Gauthier ULg et al

in Brain, Behavior & Immunity (2017), 63

Several lines of evidence indicate that early-life inflammation may predispose to mental illness, including depression, in later-life. We investigated the impact of perinatal exposure to polluted eels on ... [more ▼]

Several lines of evidence indicate that early-life inflammation may predispose to mental illness, including depression, in later-life. We investigated the impact of perinatal exposure to polluted eels on neonatal, postnatal, and adult brain inflammation, and on the resignation behavior of male and female adult offspring mice. The effects of maternal standard diet (laboratory food) were compared to the same diet enriched with low, intermediate, or highly polluted eels. Brain inflammatory markers including cytokines were assessed in offspring mice on the day of birth (i.e., on the postnatal day–PND 1), upon weaning (PND 21) and at adulthood (PND 100). Plasma myeloperoxidase and corticosterone levels were evaluated at PND 100. Immobility behavior of offspring was assessed in adulthood (i.e., at PNDs 95–100), using the tail suspension and forced swimming tests. Chronic brain inflammation was found in male and female offspring mice compared to controls, as assessed at PNDs 1, 21, and 100. The level of myeloperoxidase was found to be significantly higher in both adult males and females vs. control offspring. However, high corticosterone levels were only found in male offspring mice that were perinatally exposed to eels, suggesting a gender-selective dysregulation of the adult hypothalamicpituitaryadrenal (HPA) axis. Gender-specific differences were also detected in adulthood in regard to offspring resignation behavior. Thus, compared to controls, males, but not females, whose mothers were fed eels during pregnancy and lactation exhibited a depressive-like behavior in adult age in both behavioral models of depression. Depressive symptoms were more pronounced in male mice perinatally exposed to either intermediate or highly polluted eels than those exposed to only lowly polluted eels. Our results indicate that early-life inflammatory insult is a plausible causative factor that induce the depressive phenotype exhibited by male adult offspring mice, most likely through a gender-specific HPA axis enhanced activation. [less ▲]

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See detailL’IMAGE DU MOIS.Une tumeur cardiaque indéterminée
RADERMECKER, Régis ULg; RENSON, Virginie ULg; Delvenne, Philippe ULg et al

in Revue Médicale de Liège (2017), 72(1), 4-5

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See detailDulaglutide for the treatment of type 2 diabetes.
Scheen, André ULg

in Expert Opinion on Biological Therapy (2017), 17(4), 485-496

INTRODUCTION: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are injectable agents used for the treatment of hyperglycemia in type 2 diabetes. The interest for this pharmacological class is rising ... [more ▼]

INTRODUCTION: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are injectable agents used for the treatment of hyperglycemia in type 2 diabetes. The interest for this pharmacological class is rising with the development of once weekly compounds and the demonstration of a potential reduction in cardiorenal outcomes. Areas covered: The paper describes the main pharmacokinetic/pharmacodynamic characteristics of dulaglutide, a new once-weekly GLP-1 RA. Dulaglutide was extensively investigated in the phase-3 AWARD program, which demonstrated its safety and efficacy when compared to placebo or active glucose-lowering agents in patients treated with diet alone, metformin or sulfonylurea monotherapy, oral dual therapies and basal insulin. In both Caucasian and Japanese patients, comparative trials showed better glucose control with dulaglutide, with a minimal risk of hypoglycemia and weight loss, but at the expense of an increased dropout rate due to side effects, mostly transient gastrointestinal disturbances. Dulaglutide proved its non-inferiority versus liraglutide and the safety and tolerance profile is similar to that of other GLP-1 RAs. Expert opinion: The once-weekly formulation and the combined positive effects on both glucose control and weight improves patient satisfaction despite nausea. Dulaglutide must prove its capacity to reduce cardiovascular and diabetic complications in the ongoing prospective REWIND trial. [less ▲]

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See detailChanges in cannabis use in emerging adulthood: The influence of peer network, impulsivity, anxiety and depression
Glowacz, Fabienne ULg; Schmits, Emilie ULg

in European Review of Applied Psychology = Revue Européenne de Psychologie Appliquée (2017)

Introduction Cannabis is the most commonly used illicit drug with the highest prevalence reported among 15- to 24-year-olds. This specific period of emerging adulthood constitutes a critical age for ... [more ▼]

Introduction Cannabis is the most commonly used illicit drug with the highest prevalence reported among 15- to 24-year-olds. This specific period of emerging adulthood constitutes a critical age for substance use and for future consumption. Cannabis use patterns change during college or university and the post-college transition; users are at greater risk of adverse health outcomes (especially if they start or maintain a pattern of frequent use). Objectives The overall aim of this study was to highlight psychological and relational factors that might be associated with changes (including cessation and fluctuation) in cannabis use during this specific period, separately for males and females. Methods The subjects were 682 first-year college students (69.94% of female), aged between 18 and 25 years (M = 18.59 years, SD = 1.56). Four groups were formed according to cannabis consumption: “non-users” (54.64%), “desisting users” (14.04%), “fluctuating users” (16.23%), and “persistent users” (15.07%). A self-report questionnaire was administered to evaluate prevalence, frequency and trajectory of use, number of peer cannabis users, alcohol use, impulsivity, anxiety (trait and social) and depression. Results Females appear more sensitive to the romantic partner's consumption than males. For both sexes, having more friends who use cannabis appears to be a determinant. Depression and anxiety were not related to changes in cannabis use. Impulsivity is a significant factor for the maintenance of cannabis use in emerging adulthood, with higher lack of premeditation for males and higher sensation seeking for females among fluctuating and persistent users. Conclusions Results are discussed in terms of maintenance of use and the spiral of consumption, including clinical implications for prevention and interventions. [less ▲]

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See detailHearing “quack” and remembering a duck: Evidence for fluency attribution in young children
Geurten, Marie ULg; Lloyd, Marianne; Willems, Sylvie ULg

in Child Development (2017), 88(2), 514-522

Previous research has suggested that fluency does not influence memory decisions until age 7-8. In two experiments (n=96 and n=64, respectively), children, aged 4, 6, and 8 years (Experiment 1-2), and ... [more ▼]

Previous research has suggested that fluency does not influence memory decisions until age 7-8. In two experiments (n=96 and n=64, respectively), children, aged 4, 6, and 8 years (Experiment 1-2), and adults (Experiment 2) studied a list of pictures. Participants completed a recognition test during which each study item was preceded by a sound providing either a highly predictive or mildly predictive context in order to make some test items more conceptually fluent. Overall, highly predictive items were recognized at a higher rate than mildly predictive items demonstrating an earlier development of the fluency heuristic than previously observed. The study provides insight on how children develop metacognitive expectations and when they start to use them to guide their memory responses. [less ▲]

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See detailTestosterone-induced neuroendocrine changes in the medial preoptic area precede song activation and plasticity in song control nuclei of female canaries
Shevchouk, Olesya ULg; Ghorbanpoor, Samar; Ball, Gregory F et al

in European Journal of Neuroscience (2017), 45(7), 886-900

Testosterone plays a key role in the control of seasonal changes in singing behavior and its underlying neural circuitry. After administration of exogenous testosterone, song quality and song control ... [more ▼]

Testosterone plays a key role in the control of seasonal changes in singing behavior and its underlying neural circuitry. After administration of exogenous testosterone, song quality and song control nuclei volumes change over the course of weeks, but song rate increases within days. The medial preoptic nucleus (POM) controls sexual motivation and testosterone action in POM increases sexually motivated singing. Here, we investigated the time course of testosterone action in the song control nuclei and POM, at the gross anatomical and cellular level. Photosensitive female canaries were injected with BrdU to label newborn neurons. One day later they were transferred to a long day photoperiod and implanted with testosterone-filled or empty implants. Brains and blood were collected 1, 2, 9 or 21 days later. Testosterone increased POM volume within one day, whereas the volume of song control nuclei increased significantly only on day 21 even if a trend was already observed for HVC on day 9. The density of newborn neurons in HVC, labeled by Bromodeoxyuridine (BrdU) and doublecortin, was increased by testosterone on days 9 and 21 although a trend was already detectable on day 2. In POM testosterone increased the number and size of aromatase-immunoreactive neurons already after one day. This rapid action of testosterone in POM supports its proposed role in controlling singing motivation. Although testosterone increased the number of newborn neurons in HVC rapidly (9, possibly 2 days), it is unlikely that these new neurons affect singing behavior before they mature and integrate into functional circuits. [less ▲]

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See detailMono- and bimetallic manganese-carbonyl complexes and clusters bearing imidazol(in)ium-2-dithiocarboxylate ligands
Beltran Alvarez, Tomás Francisco ULg; Zaragoza, Guillermo; Delaude, Lionel ULg

in Dalton Transactions (2017), 46

Five complexes with the generic formula fac-[MnBr(CO)3(S2C[middle dot]NHC)] were obtained by reacting [MnBr(CO)5] with a set of representative imidazol(in)ium-2-dithiocarboxylate zwitterions. These ... [more ▼]

Five complexes with the generic formula fac-[MnBr(CO)3(S2C[middle dot]NHC)] were obtained by reacting [MnBr(CO)5] with a set of representative imidazol(in)ium-2-dithiocarboxylate zwitterions. These ligands are the adducts of N-heterocyclic carbenes (NHCs) and carbon disulfide. The mononuclear Mn(i) derivatives were coupled with Na[Mn(CO)5] to afford bimetallic [Mn2(CO)6(S2C[middle dot]NHC)] clusters. Yet, the most convenient strategy to access these dinuclear Mn(0) products implied a direct carbonyl substitution from the [Mn2(CO)10] dimer. The molecular structures of three monometallic and four bimetallic compounds were elucidated by single crystal X-ray diffraction analysis. In the monometallic complexes, the NHC[middle dot]CS2 ligands exhibited a bidentate [small kappa]2-S,S[prime or minute] coordination mode with an S-C-S bite angle of about 116[degree]. In the dinuclear clusters, the CS2- unit acted as a chelate toward one manganese center and as a pseudoallylic ligand toward the other one. The S-C-S bite angle was reduced to ca. 104[degree]. Thus, the zwitterions displayed a remarkable flexibility, which also permitted a staggered arrangement of the carbonyl groups in the bimetallic systems. Examination of the [small nu, Greek, macron]CO absorption bands on IR spectroscopy helped identify the presence of fac-Mn(CO)3 or Mn2(CO)6 motifs, while the 13C NMR chemical shift of the CS2- moiety was a reliable indicator for monitoring its hapticity. Whereas the dinuclear clusters were air- and moisture-stable crystalline solids, mononuclear halido derivatives displayed only a limited stability under aerobic conditions. Both types of compounds underwent rather unselective, extensive fragmentations in the gas phase, in sharp contrast with the analogous rhenium derivatives that led to clean sequential decarbonylation processes upon collision-induced dissociation. [less ▲]

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See detailNovel strategies for improving hematopoietic reconstruction after allogeneic hematopoietic stem cell transplantation or intensive chemotherapy.
Baron, Frédéric ULg; Nagler, Arnon

in Expert Opinion on Biological Therapy (2017)

INTRODUCTION: High-dose conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT) as well as intensive poly-chemotherapy for acute myeloid leukemia (AML) induce prolonged periods ... [more ▼]

INTRODUCTION: High-dose conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT) as well as intensive poly-chemotherapy for acute myeloid leukemia (AML) induce prolonged periods of neutropenia. The duration of the neutropenia is particularly long following umbilical cord blood transplantation (UCBT). Areas covered: After briefly reviewing the impact of hematopoietic growth factors administration to hasten hematologic reconstitution after allo-HCT or intensive AML chemotherapy, this article summarizes recent approaches that have been investigated to prompt hematologic reconstruction after UCBT or intensive AML chemotherapy. Expert opinion: In the allo-HCT setting, administration of G-CSF or GM-CSF shortened the duration of the neutropenia but failed to decrease infection-related mortality or to improve survival. Novel approaches to hasten hematological reconstruction after UCBT such as double UCBT with expansion of one of the 2 UCB units with Notch ligand, mesenchymal stromal cells, nicotinamide, or StemRegenin 1, co-transplanting a single UCB unit with HLA-haploidentical CD34+ cells, or increasing UCB HSC homing to marrow niches via direct intra bone UCB administration, pulse treatment with dmPGE2 or enforced fucosylation are promising and deserve further investigations in prospective phase III studies. In the AML setting, G-CSF or GM-CSF administration after intensive chemotherapy decreased the duration of the neutropenia without improving survival. [less ▲]

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See detailDon't judge a fish by its fins: species delineation of Congolese Labeo (Cyprinidae)
Van Steenberge, Maarten; Gajdzik, Laura ULg; Chilala, Alex et al

in Zoologica Scripta (2016)

Conspicuous characters are often useful in species identification. Yet, identification and delineation are two different processes, and such characters do not necessarily provide the best basis on which ... [more ▼]

Conspicuous characters are often useful in species identification. Yet, identification and delineation are two different processes, and such characters do not necessarily provide the best basis on which species can be delineated. This is illustrated by the case of the Labeo with papillary lips from the Congo basin. Traditionally, species delineation in this group was based on a conspicuous trait: the shape of the dorsal fin, which shows a profound degree of differentiation. Morphometric analyses were performed on 185 specimens both with and without measurements taken on this fin. The groups obtained using these two approaches were compared with those obtained through DNA barcoding. For this, 24 sequences of the standard barcoding COI gene were obtained. Species delineations based on morphological and molecular results were in agreement when the shape of the dorsal fin was ignored. This suggested that of the five nominal species known from the Congo basin, L. altivelis, L. rosae, L. lineatus, L. weeksii and L. maleboensis, only the former three remain valid. Consequently, L. weeksii was synonymised with L. altivelis and L. maleboensis with L. lineatus. The sole Congo basin endemic is L. lineatus as L. altivelis and L. rosae also occur in more southern basins. The use of the shape of the dorsal fin in morphological studies has previously led to overestimates of species diversity in this group. This is due to the fact that L. altivelis shows a remarkable amount of geographical variation for this trait. The large amount of intra- and interspecific variation in this character was caused by differential allometric growth in different parts of the dorsal fin. [less ▲]

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See detailContinuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination.
Thiry, Justine ULg; Lebrun, Pierre; Vinassa, Chloé et al

in International Journal of Pharmaceutics (2016), 515(1-2), 114-124

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See detailIs Competence a Holy Grail for Teaching? Reflections on Nursing Education
Dancot, Jacinthe ULg

in Nursing & Care Open Access Journal (2016), 1(4), 00021

The competence-based approach is largely widespread in the nursing schools and is viewed as a golden standard for professional teaching. But the practical use of the concept is varying among institutions ... [more ▼]

The competence-based approach is largely widespread in the nursing schools and is viewed as a golden standard for professional teaching. But the practical use of the concept is varying among institutions and even teachers. The goal of this narrative review is to clarify the conception of competence and its use in the fields of education and nursing. Regarding education, Gonczi, Tardif, Jonnaert and Beckers are the key authors referred to. A first apparent consensus over the holistic nature of the competence quickly gives place to the observation of important nuances in conceptions. Similarly, in the field of nursing, Benner is first discussed, and recent literature reviews and concept analyses are taken into account: similar nuances are detected, as well as difficulties in the practical implementation of the concept. Considering the lack of consensus and the paradigmaticalincoherences detected among the sources consulted for this review, we question the use of competence as single point of view for teaching and assessing, and we propose other avenues to be explored in order to recognize emergent professionality. [less ▲]

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See detailComprehension of an organosolv process for lignin extraction on Festuca arundinacea and monitoring of the cellulose degradation
Schmetz, Quentin ULg; Maniet, Guillaume ULg; Jacquet, Nicolas ULg et al

in Industrial Crops and Products (2016), 94

It is commonly accepted that the current society needs to partially substitute fossil resources by renewable ones. Among many solutions, one approach consists in the development of biorefinery involving ... [more ▼]

It is commonly accepted that the current society needs to partially substitute fossil resources by renewable ones. Among many solutions, one approach consists in the development of biorefinery involving lignocellulosic biomass to produce bio-based materials and fuels. This study focuses on the comprehension of an organosolv treatment designed to break the complex lignocellulosic structure for high purity lignin extraction from tall fescue (Festuca arundinacea Schreb.). This grass benefits from an increasing interest in Western Europe and has been suggested as feedstock for biorefinery. However, its use as material for high purity lignin production has not been determined yet. Ethanol/water, 92/8% [v/v] with H2SO4 0.32 M was investigated at pilot scale under conventional heating (5 °C min−1 during 30 min and stabilized at 148 °C for 5 min). Precipitated lignin were analyzed as well as the composition of side-stream products (recovered cellulosic pulp and the aqueous hydrolysate). Lignin has been recovered at a purity level of 90% with a yield of 60%. The main contaminants were nitrogen containing compounds and degraded hemicelluloses. 2D-HSQC NMR (Two Dimension-Heteronuclear Single Quantum Correlation Nuclear Magnetic Resonance) revealed a co-extraction of ferulates and coumarates function as well as arabinoxylan. Cellulose was recovered at 53% purity with 60% yield. The conditions appear to be too harsh for tall fescue and led to significant amount of cellulose degradation. A process using a lower alcohol concentration will be developed to provide better yields of both cellulose and lignin. [less ▲]

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See detailInterpellation du genre et sujets mélancoliques. Butler lectrice d’Althusser
Borotto, Jessica ULg

in Cahiers du GRM (2016), 8

Cet article propose d’explorer la manière dont Judith Butler remobilise la thèse althussérienne de l’interpellation dans La Vie psychique du pouvoir . Nous essaierons de saisir les éléments qui nous ... [more ▼]

Cet article propose d’explorer la manière dont Judith Butler remobilise la thèse althussérienne de l’interpellation dans La Vie psychique du pouvoir . Nous essaierons de saisir les éléments qui nous paraissent enrichir la problématique althussérienne, suggérant que la compréhension de la dimension psychique du pouvoir qui ressort de sa lecture permet de complexifier la relation du sujet au pouvoir. Afin de tisser des liens précis entre l’interpellation chez Althusser et la subjectivation chez Butler, nous examinerons d’abord le rôle que Nietzsche et Foucault recouvrent dans la formulation de la théorie de la subjectivation chez Butler. Ensuite, il s’agit de comprendre en quoi la matérialité et l’ambiguïté des mécanismes de subjectivation, qui déjà caractérisent l’interpellation althussérienne, deviennent chez Butler les sources d’une relation critique aux conditions d’émergence du sujet. Enfin nous préciserons comment elle mobilise de telles sources pour élaborer cette figure de la psychanalyse qu’est la mélancolie et pour décrire sa transformation en deuil. [less ▲]

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See detailScreening transplant donors for HTLV-1 and -2
Gallo, Robert; Willems, Luc ULg; Hasegawa, 4 Hideki et al

in Blood (2016), 128(26),

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See detailNeuromuscular blockade as part of an anaesthetic protocol for cataract surgery in an alpaca
Tutunaru, Alexandru-Cosmin ULg; Storms, Goedele ULg; Monclin, Sébastien ULg et al

in Journal of Camelid Science (2016), 9

A six-month-old alpaca was presented to the veterinary teaching hospital of the University of Liège (Belgium) with a bilateral cataract. A decision was made to perform bilateral cataract surgery after an ... [more ▼]

A six-month-old alpaca was presented to the veterinary teaching hospital of the University of Liège (Belgium) with a bilateral cataract. A decision was made to perform bilateral cataract surgery after an ocular ultrasound and electroretinogram were performed to assess the posterior segment and retinal function, respectively. As a premedication, the alpaca received xylazine, butorphanol and midazolam intramuscularly. Anaesthesia was induced subsequently with ketamine and midazolam intravenously and maintained with isoflurane on oxygen/air mixture. The alpaca was mechanically ventilated during surgery. Neuromuscular blockade was induced and maintained with cis-atracurium intravenously. The dose of cis-atracurium was permanently adapted using a peripheral nerve stimulator. This case report brings new knowledge regarding the use and dosage of cis-atracurium in alpacas. [less ▲]

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See detailSU(3) flavor symmetry breaking in large $N_c$ excited baryons
Stancu, Floarea ULg

in Physical Review. D : Particles and Fields (2016), 94

The $1/N_c$ expansion method for studying the mass spectrum of excited baryons is shortly reviewed together with applications to mixed symmetric states. The $[{\bf 70, \ell^+}]$ multiplet, belonging to ... [more ▼]

The $1/N_c$ expansion method for studying the mass spectrum of excited baryons is shortly reviewed together with applications to mixed symmetric states. The $[{\bf 70, \ell^+}]$ multiplet, belonging to the $N$ = 2 band, is reanalyzed, with emphasis on hyperons and the SU(3) symmetry breaking operators entering the mass formula to first order. An important result is that the hierarchy of masses as a function of strangeness is correctly reproduced for all multiplets. Predictions for unknown excited hyperons to SU(6) $\times$ O(3) multiplets are made. [less ▲]

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See detailEditorial
Borotto, Jessica ULg; Petteni, Oriane ULg; Wustefeld, Sophie ULg et al

in Cahiers du GRM (2016), 10

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See detailEffect of the Extraction Technique, Heating Time and Cryogenic Grinding (N2 at -196°C) on the Composition of Cumin Seeds Volatile Oil
Mékaoui, R; Benkaci-Ali, Farid; Scholl, Georges ULg et al

in Journal of Essential Oil-Bearing Plants [=JEOBP] (2016), 19(8), 1903-1919

Two techniques of extraction of essential oils (Steam distillation assisted by microwave (SDAM) and hydrodistillation assisted by microwave (HDAM)) are respectively advanced steam distillation (SD) and ... [more ▼]

Two techniques of extraction of essential oils (Steam distillation assisted by microwave (SDAM) and hydrodistillation assisted by microwave (HDAM)) are respectively advanced steam distillation (SD) and hydrodistillation techniques (HD), in which a microwave oven is used in the extraction process. They are considered as accelerated techniques extraction performed at atmospheric pressure. The cryogrinding (CG) showed a difference on the yields and aromatic profile comparing to the sample grinding. Isolation and concentration of volatile compounds are performed by a single stage for the extraction of volatile oil from Algerian (Sahara) Cuminum cyminum seeds (CCS). The chemical composition of the essential oil of this plant as a function of extraction time was also studied. The major components and family classes showed a significant variation with the extraction time. Gas chromatography (GC), GCxGC-mass spectrometry (GCxGC-MS)] were utilised for qualitative and quantitative analysis of essential oils extracted by these two methods. The major compounds are cumin aldehyde (HDAM-CG: 20.50-53.35 %, SDAM-CG: 21.68 66.6 %), p-cymene (HDAM-CG: 14.1-37.54 %, SDAM-CG: 6.06-20.18 %), β-pinene (HDAM-CG: 4.53-14.74 %, SDAM-CG: 4.3-32.65 %) and γ-terpinene (HDAM-CG: 1.26-14.70 %, SDAM-CG: 5.13-18.23 %). [less ▲]

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See detailLa SNCB : prête pour la libéralisation totale du rail ?
Gautier, Axel ULg; Salem, Iman

in Regards Economiques (2016)

La SNCB n’a pas su s’adapter à la libéralisation du fret ferroviaire faute de rentabilité. Dans la perspective d’une libéralisation du transport de passagers annoncée pour 2023, nous évaluons les ... [more ▼]

La SNCB n’a pas su s’adapter à la libéralisation du fret ferroviaire faute de rentabilité. Dans la perspective d’une libéralisation du transport de passagers annoncée pour 2023, nous évaluons les performances de l’entreprise. Notre étude met en avant un déficit de productivité et une contribution faible des passagers aux coûts par rapport à d’autres opérateurs européens. [less ▲]

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See detailNew data on the incertae sedis biota and foraminifera of the mid-Famennian Baelen Member (Late Devonian, eastern Belgium)
Vachard, Daniel; Dreesen, Roland; Mottequin, Bernard et al

in Paleobiodiversity and Paleoenvironments (2016), 21

The Baelen mud mounds in eastern Belgium represent a local member of the mid-Famennian Souverain-Pré Formation (an important carbonate interval within the Condroz Sandstone Group). The lower part of this ... [more ▼]

The Baelen mud mounds in eastern Belgium represent a local member of the mid-Famennian Souverain-Pré Formation (an important carbonate interval within the Condroz Sandstone Group). The lower part of this member contains silty bioclastic wackestones and packstones that are particularly rich in the problematical algae Serrisinella and Dreesenullella. Plurilocular foraminifera (Septabrunsiina and Baelenia) and rare solitary rugose corals (Neaxon? sp.) occur within crinoidal grainstones (tempestites) interfingering with the latter bioclastic wacke-/packstones and red-stained stromatactoid spiculitic mudstones (carbonate mound core facies). Although Serrisinella is quite common in other mid- and late Famennian limestones, of Belgium, Dreesenulella is almost endemic of the Baelen Member. Both genera apparently inhabited the muddy sediment-water interface, constituting meadows probably in zones of intermittently strong bottom currents. The taxonomic similarities between Dreesenulella and Saccamminopsis are discussed, as well as their possible affinities with the Xenophophyrea and Kokomiacea. Moreover, the first stages of the Septabrunsiina–Baelenia foraminiferal lineage are analysed in detail. The taxonomic and palaoecological positioning of Serrissinella and Dreesenulella adds to the discussion about the palaeobathymetry of the Baelen mud mounds and corroborates sedimentological evidence for their relatively shallow carbonate ramp depositional setting. [less ▲]

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See detailModel Sensitivity Studies of the Decrease in Atmospheric Carbon Tetrachloride
Chipperfield, M. P.; Liang, Q.; Rigby, M. et al

in Atmospheric Chemistry and Physics (2016), 16

Carbon tetrachloride is an ozone-depleting substance, which is controlled by the Montreal Protocol and for which the atmospheric abundance is decreasing. However, the current observed rate of this ... [more ▼]

Carbon tetrachloride is an ozone-depleting substance, which is controlled by the Montreal Protocol and for which the atmospheric abundance is decreasing. However, the current observed rate of this decrease is known to be slower than expected based on reported CCl4 emissions and its estimated overall atmospheric lifetime. Here we use a three-dimensional (3-D) chemical transport model to investigate the impact on its predicted decay of uncertainties in the rates at which CCl4 is removed from the atmosphere by photolysis, by ocean uptake and by degradation in soils. The largest sink is atmospheric photolysis (76% of total) but a reported 10% uncertainty in its combined photolysis cross-section and quantum yield has only a modest impact on the modelled rate of CCl4 decay. This is partly due to the limiting effect of the rate of transport of CCl4 from the main tropospheric reservoir to the stratosphere where photolytic loss occurs. The model suggests large interannual variability in the magnitude of this stratospheric photolysis sink caused by variations in transport. The impact of uncertainty in the minor soil sink (9% of total) is also relatively small. In contrast, the model shows that uncertainty in ocean loss (15% of total) has the largest impact on modelled CCl4 decay due to its sizeable contribution to CCl4 loss and large uncertainty range (157 to 313 years). With an assumed CCl4 emission rate of 39 Gg/yr, the reference simulation with best estimate of loss processes still underestimates the observed CCl4 (overestimates the decay) over the past two decades but to a smaller extent than previous studies. Changes to the rate of CCl4 loss processes, in line with known uncertainties, could bring the model into agreement with in situ surface and remote-sensing measurements, as could an increase in emissions to around 45 Gg/yr. Further progress in constraining the CCl4 budget is partly limited by systematic biases between observational datasets. For example, surface observations from the NOAA network are larger than from the AGAGE network but have shown a steeper decreasing trend over the past two decades. These differences imply a difference in emissions which is significant relative to uncertainties in the magnitudes of the CCl4 sinks. [less ▲]

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See detailInsights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
CHARLIER, Edith ULg; RELIC, Biserka ULg; Deroyer, Céline ULg et al

in International Journal of Molecular Sciences (2016)

Abstract: Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms. Compelling studies report the presence of ... [more ▼]

Abstract: Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms. Compelling studies report the presence of empty lacunae and hypocellularity in cartilage with aging and OA progression, suggesting that chondrocyte cell death occurs and participates to OA development. However, the relative contribution of apoptosis per se in OA pathogenesis appears complex to evaluate. Indeed, depending on technical approaches, OA stages, cartilage layers, animal models, as well as in vivo or in vitro experiments, the percentage of apoptosis and cell death types can vary. Apoptosis, chondroptosis, necrosis, and autophagic cell death are described in this review. The question of cell death causality in OA progression is also addressed, as well as the molecular pathways leading to cell death in response to the following inducers: Fas, Interleukin-1 (IL-1 ), Tumor Necrosis factor- (TNF- ), leptin, nitric oxide (NO) donors, and mechanical stresses. Furthermore, the protective role of autophagy in chondrocytes is highlighted, as well as its decline during OA progression, enhancing chondrocyte cell death; the transition being mainly controlled by HIF-1 /HIF-2 imbalance. Finally, we have considered whether interfering in chondrocyte apoptosis or promoting autophagy could constitute therapeutic strategies to impede OA progression. [less ▲]

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See detailThe role of AIP mutations in pituitary adenomas: 10 years on
Daly, Adrian ULg; BECKERS, Albert ULg

in Endocrine (2016)

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See detailThe performance of atmospheric pressure gas chromatography–tandem mass spectrometry compared to gas chromatography–high resolution mass spectrometry for the analysis of polychlorinated dioxins and PCBs in food and feed samples
ten Dam, Guillaume; Pussente, Igor; Scholl, Georges ULg et al

in Journal of Chromatography. A (2016), 1477

Recently, gas chromatography tandem mass spectrometry (GC–MS/MS) has been added in EuropeanUnion (EU) legislation as an alternative to magnetic sector high resolution mass spectrometry (HRMS) for the ... [more ▼]

Recently, gas chromatography tandem mass spectrometry (GC–MS/MS) has been added in EuropeanUnion (EU) legislation as an alternative to magnetic sector high resolution mass spectrometry (HRMS) for the analysis of dioxins and dioxin like polychlorinated biphenyls (dl-PCB) in food and feed. In this study the performance of APGC–MS/MS compared to GC–HRMS is investigated and compared with EU legislation. The study includes the legislative parameters, relative intermediate precision standard devia-tion (SRw,rel), trueness, sensitivity, linear range and ion ratio tolerance. In addition, over 200 real samplesof large variety and spanning several orders of magnitude in concentration were analyzed by both techniques and the selectivity was evaluated by comparing chromatograms. The SRw,rel and trueness were evaluated using (in-house) reference samples and fulfill to EU legislation, though the SRw,rel was better with GC–HRMS. The sensitivity was considerably better than of GC–HRMS while the linear range was similar. Ion ratios were mostly within the tolerable range of ±15%. A (temporary unresolved) systematic deviation in ion ratio was observed for several congeners, yet this did not lead to exceeding of the maxi-mum ion ratio limits. The APGC–MS/MS results for the non-dioxin-like-PCBs (ndl-PCBs) were negatively biased, particularly for PCB138 and 153 in contaminated samples. The selectivity of APGC–MS/MS was lower for several matrices. Particularly for contaminated samples, interfering peaks were observed in the APGC chromatograms of the native compounds (dioxins) and labeled internal standards (PCBs). These can lead to biased results and ultimately to false positive samples. It was concluded that the determination of dioxins and PCBs using APGC–MS/MS meets the requirements set by the European Commission. However, due to generally better selectivity and SRw,rel, GC–HRMS is the preferred method for monitoring purposes. [less ▲]

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See detailCell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus
Poncelet, Luc; Garigliany, Mutien-Marie ULg; Ando et al

in Cell Cycle (Georgetown, Tex.) (2016), 15(24), 3482-3489

The cell cycle-associated neuronal death hypothesis, which has been proposed as a common mechanism for most neurodegenerative diseases, is notably supported by evidencing cell cycle effectors in neurons ... [more ▼]

The cell cycle-associated neuronal death hypothesis, which has been proposed as a common mechanism for most neurodegenerative diseases, is notably supported by evidencing cell cycle effectors in neurons. However, in naturally occurring nervous system diseases, these markers are not expressed in neuron nuclei but in cytoplasmic compartments. In other respects, the Feline Panleukopenia Virus (FPV) is able to complete its cycle in mature brain neurons in the feline species. As a parvovirus, the FPV is strictly dependent on its host cell reaching the cell cycle S phase to start its multiplication. In this retrospective study on the whole brain of 12 cats with naturally-occurring, FPV-associated cerebellar atrophy, VP2 capsid protein expression was detected by immunostaining not only in some brain neuronal nuclei but also in neuronal cytoplasm in 2 cats, suggesting that viral mRNA translation was still occurring. In these cats, double immunostainings demonstrated the expression of cell cycle S phase markers cyclin A, cdk2 and PCNA in neuronal nuclei. Parvoviruses are able to maintain their host cells in S phase by triggering the DNA damage response. S139 phospho H2A1, a key player in the cell cycle arrest, was detected in some neuronal nuclei, supporting that infected neurons were also blocked into the S phase. PCR studies did not support a co-infection with an adeno or herpes virus. ERK1/2 nuclear accumulation was observed in some neurons suggesting that the ERK signaling pathway might be involved as a mechanism driving these neurons far into the cell cycle. [less ▲]

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See detailThe influence of spatially structured soil properties on tree community assemblages at a landscape scale in the tropical forests of southern Cameroon
Vleminckx, Jason; Doucet, Jean-Louis ULg; Morin, Julie ULg et al

in Journal of Ecology (2016)

Species distribution within plant communities results from both the influence of deterministic processes, related to environmental conditions, and neutral processes related to dispersal limitation and ... [more ▼]

Species distribution within plant communities results from both the influence of deterministic processes, related to environmental conditions, and neutral processes related to dispersal limitation and stochastic events, the relative importance of each factor depending on the observation scale. Assessing the relative contribution of environment necessitates controlling for spatial dependences among data points. Recent methods, combining multiple regression and Moran's eigenvectors maps (MEM), have been proved successful in disentangling the influence of pure spatial processes related to dispersal limitation, pure environmental variables (not spatially structured) and spatially structured environmental properties. However, the latter influence is usually not testable when using advanced spatial models like MEM. To overcome this issue, we propose an original approach, based on torus-translations and Moran spectral randomizations, to test the fraction of species abundance variation that is jointly explained by space and seven soil variables, using three environmental and tree species abundance data sets (consisting of 120, 52 and 34 plots of 0·2 ha each, located along 101-, 66- and 35-km-long transect-like inventories, respectively) collected in tropical moist forests in southern Cameroon. The overall abundance of species represented by ≥30 individuals, and 27% of these species taken individually, were significantly explained by fine-scale (<5 km) and/or broad-scale (5–100 km) spatially structured variations in soil nutrient concentrations (essentially the concentration of available Mn, Mg and Ca) along the 120-plots area. The number of significant tests considerably decreased when investigating the two smaller data sets, which mostly resulted from low statistical power rather than weaker floristic and/or edaphic variation captured among plots. Synthesis. Our results provide evidence that tree species turnovers are partly controlled by spatially structured concentrations in soil nutrients at scales ranging from few hundreds of metres to c. 100 km, a poorly documented subject in Central African forests. We also highlight the usefulness of our testing procedure to correctly interpret the space-soil fraction of variation partitioning analyses (which always accounted here for the most important part of the soil contribution), as this fraction was sometimes relatively high (R2 values up to c. 0·3) but nearly or not significant. [less ▲]

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See detailWaveform relaxation for the computational homogenization of multiscale magnetoquasistatic problems
Niyonzima, Innocent; Geuzaine, Christophe ULg; Schöps, Sebastian

in Journal of Computational Physics (2016), 327

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See detailAging of monolithic zirconia dental prostheses: Protocol for a 5-year prospective clinical study using ex vivo analyses
KOENIG, Vinciane ULg; Wulfman, Claudine; DERBANNE, Mathieu et al

in Contemporary Clinical Trials Communication (2016), 4

Background: Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a ... [more ▼]

Background: Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a wellknown problem with zirconia hip prostheses. This phenomenon could be accentuated by masticatory mechanical stress. Until now zirconia LTD process has only been studied in vitro. This work introduces an original protocol to evaluate LTD process of monolithic zirconia prostheses in the oral environment and to study their general clinical behavior, notably in terms of wear. Methods/design: 101 posterior monolithic zirconia tooth elements (molars and premolars) are included in a 5-year prospective clinical trial. On each element, several areas between 1 and 2 mm2 (6 on molars, 4 on premolars) are determined on restoration surface: areas submitted or non-submitted to mastication mechanical stress, glazed or non-glazed. Before prosthesis placement, ex vivo analyses regarding LTD and wear are performed using Raman spectroscopy, SEM imagery and 3D laser profilometry. After placement, restorations are clinically evaluated following criteria of the World Dental Federation (FDI), complemented by the analysis of fracture clinical risk factors. Two independent examiners perform the evaluations. Clinical evaluation and ex vivo analyses are carried out after 6 months and then each year for up to 5 years. Discussion: For clinicians and patients, the results of this trial will justify the use of monolithic zirconia restorations in dental practice. For researchers, the originality of a clinical study including ex vivo analyses of material aging will provide important data regarding zirconia properties. [less ▲]

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See detailLimited Impact of Imatinib in a Murine Model of Sclerodermatouc Chronic Graft-versus-Host Disease
Belle, Ludovic ULg; Fransolet, Gilles ULg; Somja, Joan ULg et al

in PLoS ONE (2016), 11

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β ... [more ▼]

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β) play a significant role in the fibrosing process occurring in scl-cGVHD. This prompted us to assess the impact of the PDGF-r and c-Abl tyrosine kinase inhibitor imatinib on scl-cGVHD. Methods To assess the impact of imatinib on T cell subset proliferation in vivo, Balb/cJ recipient mice were lethally (7 Gy) irradiated and then injected with 10x106 bone marrow cells from B10.D2 mice on day 0. Fourteen days later, 70x106 carboxyfluorescein succinimidyl ester (CFSE)-labeled splenocytes from B10.D2 mice were infused and imatinib or sterile water was administered for 5 days. To induce severe scl-cGVHD, Balb/cJ mice were injected i.v. with 10.106 bone marrow cells and 70.106 splenocytes from B10.D2 donor mice after 7 Gy irradiation. Mice were then given sterile water or imatinib from day +7 after transplantation to the end of the experiment (day +52). Results Imatinib decreased the proliferation of total T cells (P = 0.02), CD8+ T cells (P = 0.01), and of regulatory T cells (Tregs) (P = 0.02) in the spleen. In the severe scl-cGVHD model, imatinib-treated mice had significantly lower levels of PDGF-r phosphorylation than control mice on day 29 after transplantation (P = 0.008). However, scl-cGVHD scores were similar between vehicle- and imatinib-treated mice during the whole experiment, while there was a suggestion for less weight loss in imatinib-treated mice that reached statistical significance at day +52 following transplantation (P = 0.02). [less ▲]

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See detailReturn of the King: Time-Series Photometry of FO Aquarii's Initial Recovery from its Unprecedented 2016 Low State
Littlefield, Colin; Garnavich, Peter; Kennedy, Mark et al

in The Astrophysical Journal (2016), 883(93), 7

In 2016 May, the intermediate polar FO~Aqr was detected in a low state for the first time in its observational history. We report time-resolved photometry of the system during its initial recovery from ... [more ▼]

In 2016 May, the intermediate polar FO~Aqr was detected in a low state for the first time in its observational history. We report time-resolved photometry of the system during its initial recovery from this faint state. Our data, which includes high-speed photometry with cadences of just 2 sec, shows the existence of very strong periodicities at 22.5 min and 11.26 min, equivalent to the spin-orbit beat frequency and twice its value, respectively. A pulse at the spin frequency is also present but at a much lower amplitude than is normally observed in the bright state. By comparing our power spectra with theoretical models, we infer that a substantial amount of accretion was stream-fed during our observations, in contrast to the disk-fed accretion that dominates the bright state. In addition, we find that FO~Aqr's rate of recovery has been unusually slow in comparison to rates of recovery seen in other magnetic cataclysmic variables, with an e-folding time of 115±7 days. The recovery also shows irregular variations in the median brightness of as much as 0.2~mag over a 10-day span. Finally, we show that the arrival times of the spin pulses are dependent upon the system's overall brightness. [less ▲]

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See detailBrisons le système, pouvoir aux femmes ! (Padoue, 1974)
Borotto, Jessica ULg

in Cahiers du GRM (2016), 10

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See detailIntroduction du Dossier de traduction
Borotto, Jessica ULg; Cavazzini, Andrea

in Cahiers du GRM (2016), 10

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See detailCorrecting circulation biases in a lower-resolution global general circulation model with data assimilation
Canter, Martin ULg; Barth, Alexander ULg; Beckers, Jean-Marie ULg

in Ocean Dynamics (2016)

In this study, we aim at developing a new method of bias correction using data assimilation. This method is based on the stochastic forcing of a model to correct bias by directly adding an additional ... [more ▼]

In this study, we aim at developing a new method of bias correction using data assimilation. This method is based on the stochastic forcing of a model to correct bias by directly adding an additional source term into the model equations. This method is presented and tested first with a twin experiment on a fully controlled Lorenz ’96 model. It is then applied to the lower-resolution global circulation NEMO-LIM2 model, with both a twin experiment and a real case experiment. Sea surface height observations are used to create a forcing to correct the poorly located and estimated currents. Validation is then performed throughout the use of other variables such as sea surface temperature and salinity. Results show that the method is able to consistently correct part of the model bias. The bias correction term is presented and is consistent with the limitations of the global circulation model causing bias on the oceanic currents. [less ▲]

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See detailRésister à l’essentialisation de l’Allemagne : Les Temps Modernes, revue franco-allemande ?
Franck, Thomas ULg

in Trajectoires (2016), 10

Im Zentrum des vorliegenden Aufsatzes steht die Doppelausgabe (46-47) der französischen Zeitschrift Temps Modernes, die unter dem Titel „Allemagne“ im August-September 1949 erschien und einen besonderen ... [more ▼]

Im Zentrum des vorliegenden Aufsatzes steht die Doppelausgabe (46-47) der französischen Zeitschrift Temps Modernes, die unter dem Titel „Allemagne“ im August-September 1949 erschien und einen besonderen Fall von kulturellem und intellektuellem Transfer zwischen Deutschland und Frankreich darstellt. Mit Mitteln der Diskursanalyse und der Imagologie sollen hier rhetorische Strategien herausgearbeitet werden, die der Realisierung eines kritischen Projekts und der Anprangerung der Stereotypen dienen, die Deutschland damals zugeschrieben wurden. Aufgestellt wird folgende These: Indem sie Intellektuelle aus unterschiedlichen Orten und Disziplinen und heterogenes Wissen zusammenbringt, bietet sich die Zeitschrift besonders gut für eine kritische Reflexion der herrschenden Ideologien und kollektiven Überzeugungen an. Indem es Deutschen mit kommunistischer und antifaschistischer Gesinnung das Wort erteilt, will das Heft „Allemagne“ zu Erkenntnissen über ein ‚anderes Deutschland‘ kommen, das von Aufstand und Widerstand geprägt ist, und bricht so mit einer Reduktion des Landes auf eine unveränderliche und monolithische Identität, die als gleichermaßen fügsam und autoritär verstanden wurde. [less ▲]

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See detailIn vitro evaluation of biocompatibility of uncoated thermally reduced graphene and carbon nanotube-loaded PVDF membranes with adult neural stem cell-derived neurons and glia
Defteralı, Çağla; Verdejo, Raquel; Majeed, Shahid et al

in Frontiers in Bioengineering and Biotechnology (2016), 4(n° 64),

Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were ... [more ▼]

Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were seeded on these materials coated with various proteins implying that the observed effects on the cells could not solely be attributed to the GBN and CNT properties. Here, we studied the biocompatibility of uncoated thermally reduced graphene (TRG) and poly(vinylidene fluoride) (PVDF) membranes loaded with multi-walled CNTs (MWCNTs) using neural stem cells isolated from the adult mouse olfactory bulb (termed aOBSCs). When aOBSCs were induced to differentiate on coverslips treated with TRG or control materials (polyethyleneimine-PEI and polyornithine plus fibronectin- PLO/F) in a serum-free medium, neurons, astrocytes, and oligodendrocytes were generated in all conditions, indicating that TRG permits the multi-lineage differentiation of aOBSCs. However, the total number of cells was reduced on both PEI and TRG. In a serum-containing medium, aOBSC-derived neurons and oligodendrocytes grown on TRG were more numerous than in controls; the neurons developed synaptic boutons and oligodendrocytes were more branched. In contrast, neurons growing on PVDF membranes had reduced neurite branching, and on MWCNTs-loaded membranes oligodendrocytes were lower in numbers than in controls. Overall, these findings indicate that uncoated TRG may be biocompatible with the generation, differentiation, and maturation of aOBSC-derived neurons and glial cells, implying a potential use for TRG to study functional neuronal networks. [less ▲]

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See detailDynamics of the flares in the active polar region of Jupiter
Bonfond, Bertrand ULg; Grodent, Denis ULg; Badman, S. V. et al

in Geophysical Research Letters (2016)

The dusk-side of the polar region of Jupiter's UV aurorae, called the active region, sometimes exhibits quasi-periodic (QP) flares on time-scales of 2-3 minutes. Based on Hubble Space Telescope Far-UV ... [more ▼]

The dusk-side of the polar region of Jupiter's UV aurorae, called the active region, sometimes exhibits quasi-periodic (QP) flares on time-scales of 2-3 minutes. Based on Hubble Space Telescope Far-UV time-tag images, we show for the first time that the northern hemisphere also displays QP-flares. The area covered by these flares can reach up to 2.4 × 108 km2 (i.e. the whole active region), but often only involves an area an order of magnitude smaller. Using a magnetic field mapping model, we deduced that these areas correspond to the dayside outer magnetosphere. In our dataset, quasi-periodic features are only seen on half of the cases and even on a given observation, a region can be quiet for one half and blinking on the other half. Consecutive observations in the two hemispheres show that the brightening can occur in phase. Combined with the size and location of the flares, this behaviour suggests that the QP-flares most likely take place on closed magnetic field lines. [less ▲]

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See detailAging Processes in Lithiated FeSn2 Based Negative Electrode for Li-ion Batteries: a New Challenge for Tin Based Intermetallic Materials
chamas, mohamad; Mahmoud, Abdelfattah ULg; Tang, Junlei et al

in Journal of Physical Chemistry C (2016)

Tin based intermetallic compounds proposed as negative electrode materials for Li-ion batteries not only suffer from capacity fade during cycling due to volume variations but also from aging phenomena in ... [more ▼]

Tin based intermetallic compounds proposed as negative electrode materials for Li-ion batteries not only suffer from capacity fade during cycling due to volume variations but also from aging phenomena in lithiated states. By using FeSn2 as a model compound, we propose an analysis of this process by combining electrochemical potential measurements, 119Sn and 57Fe Mössbauer spectroscopies, magnetic measurements and impedance spectroscopy. We show that the Fe/Li7Sn2 composite obtained at the end of the first discharge is progressively transformed during the aging process occurring within the electrochemical cell in open circuit condition. The Fe nanoparticles are stable while the Li7Sn2 nanoparticles are progressively delithiated with time leading to Sn-rich LixSn nano-alloys without observable back reaction with Fe. The deinserted lithium atoms react with the electrolyte and modify the surface electrode interphase (SEI) by increasing its thickness and/or decreasing its porosity [less ▲]

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See detailLa reconnaissance des génocides et la répression du négationnisme
Grandjean, Geoffrey ULg

in Courrier Hebdomadaire du CRISP (2016), 2304-2305

La reconnaissance politique d’un génocide et la répression de la négation de celui-ci représentent deux enjeux d’une grande importance symbolique. Surtout, elles constituent un exercice très délicat pour ... [more ▼]

La reconnaissance politique d’un génocide et la répression de la négation de celui-ci représentent deux enjeux d’une grande importance symbolique. Surtout, elles constituent un exercice très délicat pour l’autorité politique qui pose de tels actes. Il s’agit en effet de consacrer une vérité historique et de dicter le souvenir qui doit en être véhiculé. L’intervention d’une instance politique dans le champ de l’histoire et de la mémoire est toujours entourée de nombreux débats. Les discussions, souvent vives, portent sur diverses questions. Le principe d’une action législative dans un tel domaine est-il recevable et pertinent ? Quelle définition de « génocide » convient-il d’adopter ? La répression du négationnisme est-elle de nature à justifier une limitation de la liberté d’expression ? Si oui, dans quelle mesure cette restriction s’applique-t-elle aussi aux chercheurs ? Lorsqu’il s’agit d’événements historiques relatifs à un autre État, faut-il faire primer l’éthique et la morale sur la diplomatie ? Les réponses à ces interrogations fondamentales se cristallisent dans des lignes de fracture qui échappent aux clivages partisans classiques. En Belgique, les initiatives de reconnaissance des crimes de génocide et de pénalisation de leur négation sont le fait des deux chambres du Parlement fédéral. Elles ont abouti à diverses dispositions législatives, telles la loi réprimant la négation du génocide commis par le régime nazi à l’encontre des Juifs pendant la Seconde Guerre mondiale (1995), une résolution relative au génocide perpétré par l’Empire ottoman à l’encontre des Arméniens en 1915 (1998), une résolution sur le génocide des Tutsis au Rwanda en 1994 (2004) et une résolution relative à la commémoration du centenaire du génocide arménien (2015). G. Grandjean retrace et éclaire l’ensemble des débats parlementaires qui se sont tenus en Belgique depuis 1992 autour de la question de la mémoire des crimes de masse. Son Courrier hebdomadaire offre les clés de lecture pour la compréhension des débats en cours quant à une extension de la loi de 1995. [less ▲]

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See detailWASP-92b, WASP-93b and WASP-118b: Three new transiting close-in giant planets
Hay, K. L.; Collier-Cameron, A.; Doyle, A. P. et al

in Monthly Notices of the Royal Astronomical Society (2016), 463

We present the discovery of three new transiting giant planets, first detected with the WASP telescopes, and establish their planetary nature with follow up spectroscopy and ground-based photometric ... [more ▼]

We present the discovery of three new transiting giant planets, first detected with the WASP telescopes, and establish their planetary nature with follow up spectroscopy and ground-based photometric lightcurves. WASP-92 is an F7 star, with a moderately inflated planet orbiting with a period of 2.17 days, which has R[SUB]p[/SUB] = 1.461 ± 0.077R[SUB]J[/SUB] and M[SUB]p[/SUB] = 0.805 ± 0.068M[SUB]J[/SUB]. WASP-93b orbits its F4 host star every 2.73 days and has R[SUB]p[/SUB] = 1.597 ± 0.077R[SUB]J[/SUB] and M[SUB]p[/SUB] = 1.47 ± 0.029M[SUB]J[/SUB]. WASP-118b also has a hot host star (F6) and is moderately inflated, where R[SUB]p[/SUB] = 1.440 ± 0.036R[SUB]J[/SUB] and M[SUB]p[/SUB] = 0.514 ± 0.020M[SUB]J[/SUB] and the planet has an orbital period of 4.05 days. They are bright targets (V = 13.18, 10.97 and 11.07 respectively) ideal for further characterisation work, particularly WASP-118b, which is being observed by K2 as part of campaign 8. The WASP-93 system has sufficient angular momentum to be tidally migrating outwards if the system is near spin-orbit alignment, which is divergent from the tidal behaviour of the majority of hot Jupiters discovered. [less ▲]

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