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See detailTowards Participatory Integrated Valuation and Modelling of Ecosystem Services under Land-use Change
Fontaine, C.; Dendoncker, N.; De Vreese, R. et al

in Journal of Land Use Science (2014), 9

The lack of consideration for Ecosystem Services (ES) values in current decision-making is recognised as one of the main reasons leading to an intense competition and arguably unsustainable use of well ... [more ▼]

The lack of consideration for Ecosystem Services (ES) values in current decision-making is recognised as one of the main reasons leading to an intense competition and arguably unsustainable use of well-located available land. In this paper, we present a framework for the Valuation Of Terrestrial Ecosystem Services (VOTES), aiming at structuring a methodology that is applicable for valuing ES in a given area through a set of indicators that are both meaningful for local actors and scientifically constructed. Examples from a case study area in central Belgium are used to illustrate the methodology: a stepwise procedure starting with the valuation of ES at present. The valuation of the social, biophysical and economic dimensions of ES are based on current land-use patterns. Subsequently, scenarios of land-use change are used to explore potential losses (and/or gains) of ES in the future of the study area. With the VOTES framework, we aim at [1] incorporating stakeholders inputs to widen the valuation process and increase trust in policy-oriented approach; [2] integrating valuation of ES with a sustainable development stance accounting for land-use change; and [3] developing suggestions to policy-makers for integrating ES monitoring in policy developments. [less ▲]

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See detailLa santé bucco-dentaire des personnes âgées
Lamy, Marc ULg

in Revue Médicale de Liège (2014)

La santé bucco-dentaire est mauvaise chez les personnes âgées, qu’elles vivent à domicile, ou, plus encore, en milieu institutionnalisé. La prévalence des patients édentés totaux est presque toujours ... [more ▼]

La santé bucco-dentaire est mauvaise chez les personnes âgées, qu’elles vivent à domicile, ou, plus encore, en milieu institutionnalisé. La prévalence des patients édentés totaux est presque toujours supérieure à 50 % et le nombre moyen de dents présentes en bouche, chez les patients dentés, est de dix. Cette situation a des conséquences sur la qualité de vie, la nutrition, les maladies cardiovasculaires et les pneumopathies des personnes âgées. Des mesures doivent être mises en place pour changer ce triste constat. [less ▲]

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See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

in European Financial Management (2014), forthcoming

This paper singles out the key roles of US equity skewness and kurtosis in the hedge fund return generating process. We propose a conditional higher-moment model with location, trading, and higher-moment ... [more ▼]

This paper singles out the key roles of US equity skewness and kurtosis in the hedge fund return generating process. We propose a conditional higher-moment model with location, trading, and higher-moment factors to describe the dynamics of the equity hedge, event-driven, relative value, and fund of funds styles. If the volatility, skewness, and kurtosis implied in US options are used by fund managers as instruments to anticipate market movements, managers should adjust their market exposure in response to variations in these moments. We indeed show that higher-moment premia improve the conditional asset pricing model across all hedge fund styles. [less ▲]

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See detailMagnetic ghosts and monopoles
Vandewalle, Nicolas ULg; Dorbolo, Stéphane ULg

in New Journal of Physics (2014), 16

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See detailquelques messages choisis de l'ECCO 17
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2014), 8(1), 8-11

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See detailCharacterization and modeling of a scroll expander with air and ammonia as working fluid
Mendoza, Luis Carlos; Navarro-Esbrí; Bruno, Joan Carles et al

in Applied Thermal Engineering (2014), 70

This paper presents the experimental characterization and modeling of a scroll expander. The expander used here is a scroll compressor modified to work as an expander. It is characterized in two ... [more ▼]

This paper presents the experimental characterization and modeling of a scroll expander. The expander used here is a scroll compressor modified to work as an expander. It is characterized in two experimental setups using air and ammonia as working fluids. The paper studies how the main operating variables (supply pressure and temperature, pressure ratio, rotational speed and lubrication) influence the performance of the scroll expander. A semi-empirical model is proposed to determine the scroll expander performance. This model uses some semi-empirical parameters (such as built-in volume ratio, leakage area and mechanical losses), obtained through experimentation, to calculate the mechanical power, supply mass flow rate and exhaust temperature. Using this semi-empirical model, the deviations in the calculated mechanical power, exhaust temperature and supply mass flow rate are ±9%, ±4 K and ±5% Hz. [less ▲]

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See detailIsocinétisme et douleurs musculaires d’apparition retardée
Hody, Stéphanie ULg; ROGISTER, Bernard ULg; Leprince, Pierre ULg et al

in Movement & Sport Sciences - Science & Motricité (2014)

The curative and preventive efficiency of the isokinetic exercise, especially of the eccentric contraction, has been well demonstrated. However, intense or unusual eccentric exercise is known to induce ... [more ▼]

The curative and preventive efficiency of the isokinetic exercise, especially of the eccentric contraction, has been well demonstrated. However, intense or unusual eccentric exercise is known to induce muscle damage associated with delayed-onset muscle soreness (DOMS) and prolonged functional deficits. These negative consequences can frequently disturb the progress of re-education or training programmes. Since they can affect athletic performance and increase the risk of musculo-skeletal injuries, the structuro-functional alterations associated with DOMS may also be problematic in athletes. Therefore, to optimize the benefits of the eccentric work while avoiding muscle damage and occurrence of DOMS should represent a major objective for the practitioners. To date, the only systematic intervention that brings muscle protection against DOMS consists of performing repeated eccentric sessions at submaximal intensity. Besides its clinical use, isokinetic constitutes an interesting model to generate and investigate the DOMS phenomenon. The original association of eccentric injuring protocols with new emerging techniques of molecular biology appears to be a promising strategy to better understand the cellular and molecular mechanisms underlying exercise-induced muscle damage. Such data would provide better guidelines for prevention or treatment practice. [less ▲]

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See detailPrix prédateurs : La Cour d’appel de Paris saisit l’Autorité de la Concurrence d’une demande d’avis pour apprécier le caractère prédateur d’un prix nul
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2014), 1

CA Paris, 20 novembre 2013, Google France et Google c/ Bottin Cartographe

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See detailIntense pulsed light in infantile hemangiomas.
PAQUET, Philippe ULg; Caucanas, Marie; FRANCHIMONT, Claudine ULg et al

in Open Access Journal of Science and Technology (2014), 2

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of ... [more ▼]

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of well-suited beta-blockers, as well as noncoherent light and laser therapies. The aim of this work was to revisit the effect of intense pulsed light (IPL) therapy on infantile hemangioma. Information was collected from the peer-reviewed literature and illustrated by personal cases. When applied early in the evolution of infantile hemangiomas, IPL treatment stops the growth phase and induces regression with minimal cosmetic adverse effects and psychological damage. Initiating an adequate treatment is important because damage due to hemangiomas can be diminished by a timely and adequate approach. Beta-blockers have revolutionized the therapeutic strategy of infantile hemangiomas. The flash light therapy (IPL) represents an alternative therapy for some patients. [less ▲]

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See detailRecommandations europeennes concernant la therapie de resynchronisation cardiaque.
ROBINET, Sébastien ULg; DELCOUR, Alexandre ULg; Lancellotti, Patrizio ULg

in Revue medicale de Liege (2014), 69(4), 180-7

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In ... [more ▼]

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In this article, we summarize the recommendations of the European Society of Cardiology of 2013 on cardiac resynchronization therapy. [less ▲]

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See detailEarly detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model.
MORIMONT, Philippe ULg; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in Medical engineering & physics (2014)

AIMS: The time constant of left ventricular (LV) relaxation derived from a monoexponential model is widely used as an index of LV relaxation rate, although this model does not reflect the non-uniformity ... [more ▼]

AIMS: The time constant of left ventricular (LV) relaxation derived from a monoexponential model is widely used as an index of LV relaxation rate, although this model does not reflect the non-uniformity of ventricular relaxation. This study investigates whether the relaxation curve can be better fitted with a "quadratic" model than with the "conventional" monoexponential model and if changes in the LV relaxation waveform due to acute myocardial ischemia could be better detected with the quadratic model. METHODS AND RESULTS: Isovolumic relaxation was assessed with quadratic and conventional models during acute myocardial ischemia performed in 6 anesthetized pigs. Mathematical development indicates that one parameter (Tq) of the quadratic model reflects the rate of LV relaxation, while the second parameter (K) modifies the shape of the relaxation curve. Analysis of experimental data obtained in anesthetized pigs showed that the shape of LV relaxation consistently deviates from the conventional monoexponential decay. During the early phase of acute myocardial ischemia, the rate and non-uniformity of LV relaxation, assessed with the quadratic function, were significantly enhanced. Tq increased by 16% (p<0.001) and K increased by 12% (p<0.001) within 30 and 60min, respectively, after left anterior descending (LAD) coronary artery occlusion. However, no significant changes were observed with the conventional monoexponential decay within 60min of ischemia. CONCLUSIONS: The quadratic model better fits LV isovolumic relaxation than the monoexponential model and can detect early changes in relaxation due to acute myocardial ischemia that are not detectable with conventional methods. [less ▲]

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See detailLack of isocitrate lyase in Chlamydomonas leads to changes in carbon metabolism and in the response to oxidative stress under mixotrophic growth.
Plancke, Charlotte; Vigeolas, Hélène ULg; Hohner, Ricarda et al

in The Plant journal : for cell and molecular biology (2014), 77(3), 404-417

Isocitrate lyase is a key enzyme of the glyoxylate cycle. This cycle plays an essential role in cell growth on acetate, and is important for gluconeogenesis as it bypasses the two oxidative steps of the ... [more ▼]

Isocitrate lyase is a key enzyme of the glyoxylate cycle. This cycle plays an essential role in cell growth on acetate, and is important for gluconeogenesis as it bypasses the two oxidative steps of the tricarboxylic acid (TCA) cycle in which CO2 is evolved. In this paper, a null icl mutant of the green microalga Chlamydomonas reinhardtii is described. Our data show that isocitrate lyase is required for growth in darkness on acetate (heterotrophic conditions), as well as for efficient growth in the light when acetate is supplied (mixotrophic conditions). Under these latter conditions, reduced acetate assimilation and concomitant reduced respiration occur, and biomass composition analysis reveals an increase in total fatty acid content, including neutral lipids and free fatty acids. Quantitative proteomic analysis by 14 N/15 N labelling was performed, and more than 1600 proteins were identified. These analyses reveal a strong decrease in the amounts of enzymes of the glyoxylate cycle and gluconeogenesis in parallel with a shift of the TCA cycle towards amino acid synthesis, accompanied by an increase in free amino acids. The decrease of the glyoxylate cycle and gluconeogenesis, as well as the decrease in enzymes involved in beta-oxidation of fatty acids in the icl mutant are probably major factors that contribute to remodelling of lipids in the icl mutant. These modifications are probably responsible for the elevation of the response to oxidative stress, with significantly augmented levels and activities of superoxide dismutase and ascorbate peroxidase, and increased resistance to paraquat. [less ▲]

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See detailEndogenous Altruism, Redistribution, and Long Term Care
Pestieau, Pierre ULg; Cremer, Helmuth; Gahvari, Firouz

in B.E. Journal of Economic Analysis & Policy (2014), 14(2), 499-524

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See detailEffectiveness of PHARMAceutical care for patients with COPD (PHARMACOP): a randomized controlled trial
Tommelein, Eline; Mehuys, Els; Van Hees, Thierry ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 756-766

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary ... [more ▼]

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary Disease (COPD) have been conducted. We assessed the effectiveness of a pharmaceutical care program for patients with COPD. METHODS: The PHARMACOP-trial is a single-blind 3-month RCT, conducted in 170 community pharmacies in Belgium, enrolling patients prescribed daily COPD medication, aged >/=50 years, and with a smoking history >/=10 pack-years. A computer-generated randomization sequence allocated patients to intervention (n=371), receiving protocol-defined pharmacist care, or control group (n=363), receiving usual pharmacist care (1:1 ratio, stratified by center). Interventions, focusing on inhalation technique and adherence to maintenance therapy, were carried out at start of the trial and at one month follow-up. Primary outcomes were inhalation technique and medication adherence. Secondary outcomes were exacerbation rate, dyspnea, COPD specific and generic health status and smoking behavior. RESULTS: From December 2010 to April 2011, 734 patients were enrolled. 42 patients (5.7%) were lost to follow-up. At the end of the trial, inhalation score (Mean estimated difference [Delta],13.5%; 95% Confidence Interval [CI], 10.8-16.1; P<.0001) and medication adherence (Delta, 8.51%; 95%CI, 4.63-12.4; P<.0001) were significantly higher in the intervention group compared to the control group. In the intervention group, a significantly lower hospitalization rate was observed (9 vs 35; Rate Ratio, 0.28; 95%CI, 0.12-0.64; P=.003). No other significant between-group differences were observed. CONCLUSION: Pragmatic pharmacist care programs improve the pharmacotherapeutic regime in patients with COPD and could reduce hospitalization rates. [less ▲]

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See detailRemarkably low genetic diversity and strong population structure in common bottlenose dolphins (Tursiops truncatus) from coastal waters of the Southwestern Atlantic Ocean
Fruet, Pedro; Secchi, Eduardo; Daura-Jorge, Fabio et al

in Conservation Genetics (2014)

Knowledge about the ecology of bottlenose dolphins in the Southwestern Atlantic Ocean is scarce. Increased by-catch rates over the last decade in coastal waters of southern Brazil have raised concerns ... [more ▼]

Knowledge about the ecology of bottlenose dolphins in the Southwestern Atlantic Ocean is scarce. Increased by-catch rates over the last decade in coastal waters of southern Brazil have raised concerns about the decline in abundance of local dolphin communities. Lack of relevant data, including information on population structure and connectivity, have hampered an assessment of the conservation status of bottlenose dolphin communities in this region. Here we combined analyses of 16 microsatellite loci and mitochondrial DNA (mtDNA) control region sequences to investigate genetic diversity, structure and connectivity in 124 biopsy samples collected over six communities of photographically identified coastal bottlenose dolphins in southern Brazil, Uruguay and central Argentina. Levels of nuclear genetic diversity were remarkably low (mean values of allelic diversity and heterozygosity across all loci were 3.6 and 0.21, respectively), a result that possibly reflects the small size of local dolphin communities. On a broad geographical scale, strong and significant genetic differentiation was found between bottlenose dolphins from southern Brazil-Uruguay (SB-U) and Baia San Antonio (BSA), Argentina (AMOVA mtDNA ΦST = 0.43; nuclear FST = 0.46), with negligible contemporary gene flow detected based on Bayesian estimates. On a finer scale, moderate but significant differentiation (AMOVA mtDNA ΦST = 0.29; nuclear FST = 0.13) and asymmetric gene flow was detected between five neighbouring communities in SB-U. Based on the results we propose that BSA and SB-U represent two distinct Evolutionarily Significant Units (ESUs), and that communities from SB-U comprise five distinct Management Units (MUs). Under this scenario, conservation efforts should prioritize the areas in Southern Brazil where dolphins from three MUs overlap in their home ranges and where by-catch rates are reportedly higher. [less ▲]

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See detailLa gouvernance environnementale au Sud : regard sur un projet de conservation des tortues au Sri Lanka
Rosillon, Caroline ULg

in ethnographiques.org (2014), 27

Les régions rurales du Sud du Sri Lanka sont soumises aujourd'hui à des tensions croissantes entre un développement économique précipité et la conservation des ressources naturelles qui participent à la ... [more ▼]

Les régions rurales du Sud du Sri Lanka sont soumises aujourd'hui à des tensions croissantes entre un développement économique précipité et la conservation des ressources naturelles qui participent à la renommée de l'île. Dans ce contexte, l'article se penche sur la question des initiatives locales de protection de la biodiversité à travers une étude de cas portant sur un projet de conservation des tortues de mer dans le district d'Hambantota (l'ONG-T). Dans une perspective d'anthropologie politique, l'analyse met en lumière la manière dont ce type de projet s'intègre et influence les structures sociopolitiques dans la société locale. Après avoir brièvement présenté quelques données contextuelles et historiques sur le village de pêcheurs dans laquelle est implantée l'ONG, l'étude de cas révèle les nouvelles formes d'interactions, les enjeux de pouvoirs et les conflits que peut susciter localement l'implantation de ce type de projet. [less ▲]

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See detailConcomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects
Vignisse, Julie ULg; Steinbusch, Harry W.M.; Grigoriev, Vladimir et al

in European Neuropsychopharmacology (2014), 24

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA ... [more ▼]

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA receptors or the potentiation of AMPA receptors is well documented to result in memory enhancement. Here, we compared the efficacy of the low-affinity NMDA receptor blocker memantine or the positive modulator of AMPA receptor QXX (in C57BL/6J at 1 or 5 mg/kg, ip) with new derivatives of isothiourea (0.5-1 mg/kg, ip) that have bifunctional efficacy. Low-affinity NMDA blockade by these derivatives was achieved by introducing greater flexibility into the molecule, and AMPA receptor stimulation was produced by a sulfamide-containing derivative of isothiourea. Contextual learning was examined in a step-down avoidance task and extinction of contextual memory was studied in a fear-conditioning paradigm. Memantine enhanced contextual learning while QXX facilitated memory extinction; both drugs were effective at 5 mg/kg. The new derivative IPAC-5 elevated memory scores in both tasks at the dose 0.5 mg/Kg and exhibited the lowest IC50 values of NMDA receptor blockade and highest potency of AMPA receptor stimulation. Thus, among the new drugs tested, IPAC-5 plicated the properties of memantine and QXX in one administration with increased potency. Our data suggest that a concomitant manipulation of NMDA- and AMPA-receptors results in pro-cognitive effects and supports the concept bifunctional drug therapy as a promising strategy to replace monofunctional therapies with greater efficacy and improved compliance. [less ▲]

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See detailNew role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline ULg; Renert, Anne-Françoise; Merville, Marie-Paule ULg et al

in Autophagy (2014)

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]

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See detailPhysicochemical characterization and in vitro assessment of the nutritive value of starch yield from corn dried at different temperatures
Malumba, P.; Odjo, S.; Boudry, Christelle ULg et al

in Stärke = Starch (2014), 66

To assess modifications induced in starch granules during high temperature drying of corn grain and their effect on the nutritive value of corn-starch, physicochemical and structural characteristics of ... [more ▼]

To assess modifications induced in starch granules during high temperature drying of corn grain and their effect on the nutritive value of corn-starch, physicochemical and structural characteristics of starch granules from corn grains dried at different temperatures have been determined. Additionally, their in vitro digestibility and fermentation patterns were investigated, using a two steps in vitro model of the pig digestive tract. High drying temperatures induced a partial gelatinization of starch granules and produced a very favorable substrate for porcine pancreatic amylase and led to an altered physical structure which affected the rate and extent of starch granules digestion by gastric and pancreatic enzymes. Starch micrographs showed that granules extracted from corn dried at 130°C were less angular, bigger, and had smoother surface than granules extracted from corn dried at lower temperature. High-temperature drying increased the digestibility of wet-milled starch granules, while the residues of starch from corn dried at lower temperature produced higher volume of gas during their in vitro fermentation, despite their more pronounced crystalline characteristic. The residues from pepsin–pancreatic digestion of overall samples analyzed showed highly degraded and pitted granules or fragmented external shells, starch from corn dried at 130°C being the most degraded. Aforementioned changes of nutritional attributes of starch granules are discussed according to the restructuration occurring within both their amorphous and crystalline phase, as well as to the changes of the granules size and purity. [less ▲]

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See detailA frontal approach to hex-dominant mesh generation
Baudouin, Tristan Carrier; Remacle, Jean-François; Marchandise, Emilie et al

in Advanced Modeling and Simulation in Engineering Sciences (2014), 1(1), 1-30

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See detailHypothalamic response to the chemo-signal androstadienone in gender dysphoric children and adolescents.
Burke, Sarah M.; Cohen-Kettenis, Peggy T.; Veltman, Dick J. et al

in Frontiers in endocrinology (2014), 5

The odorous steroid androstadienone, a putative male chemo-signal, was previously reported to evoke sex differences in hypothalamic activation in adult heterosexual men and women. In order to investigate ... [more ▼]

The odorous steroid androstadienone, a putative male chemo-signal, was previously reported to evoke sex differences in hypothalamic activation in adult heterosexual men and women. In order to investigate whether puberty modulated this sex difference in response to androstadienone, we measured the hypothalamic responsiveness to this chemo-signal in 39 pre-pubertal and 41 adolescent boys and girls by means of functional magnetic resonance imaging. We then investigated whether 36 pre-pubertal children and 38 adolescents diagnosed with gender dysphoria (GD; DSM-5) exhibited sex-atypical (in accordance with their experienced gender), rather than sex-typical (in accordance with their natal sex) hypothalamic activations during olfactory stimulation with androstadienone. We found that the sex difference in responsiveness to androstadienone was already present in pre-pubertal control children and thus likely developed during early perinatal development instead of during sexual maturation. Adolescent girls and boys with GD both responded remarkably like their experienced gender, thus sex-atypical. In contrast, pre-pubertal girls with GD showed neither a typically male nor female hypothalamic activation pattern and pre-pubertal boys with GD had hypothalamic activations in response to androstadienone that were similar to control boys, thus sex-typical. We present here a unique data set of boys and girls diagnosed with GD at two different developmental stages, showing that these children possess certain sex-atypical functional brain characteristics and may have undergone atypical sexual differentiation of the brain. [less ▲]

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See detailKinetic study of 4-nitrophenol photocatalytic degradation over a Zn2+ doped TiO2 catalyst prepared through an environmentally friendly aqueous sol–gel process
Malengreaux, Charline ULg; Pirard, Sophie ULg; Bartlett, John et al

in Chemical Engineering Journal (2014), 245

A kinetic study of the photocatalytic degradation of 4-nitrophenol (4-NP) under UV–visible light (330 nm < k < 800 nm) has been performed via a rigorous chemical engineering approach over a Zn2+ doped ... [more ▼]

A kinetic study of the photocatalytic degradation of 4-nitrophenol (4-NP) under UV–visible light (330 nm < k < 800 nm) has been performed via a rigorous chemical engineering approach over a Zn2+ doped TiO2 catalyst prepared through an environmentally friendly aqueous sol–gel process. The experiments have been performed at three temperatures to enable the global activation energy to be estimated. The influence of the illumination intensity has also been considered. The possibility of internal and external diffusion limitations has been studied and the results obtained demonstrated that there is no diffusional limitation during the photocatalytic degradation of the 4-NP using the selected catalyst. Therefore, the apparent specific reaction rate measured corresponds to the actual reaction rate of the chemical reaction. Parameter adjustments show that the kinetic model that provides the best fit to the experimental data corresponds to a first order reaction. A sequence of elementary steps has been considered and a pseudo-steady state approach based upon the stationary state hypothesis for reaction intermediates has been applied to obtain a kinetic rate expression in agreement with the experimental data. The mean values of the reaction rate constant found at 283 K, 288 K and 293 K are respectively equal to k1 = 0.094 ± 0.003 m3 h- 1 kgcatalyst- 1; k2 = 0.119 ± 0.004 m3 h- 1 kgcatalyst- 1 and k3 = 0.150 ± 0.023 m3 h- 1 kg catalyst-1 and the global activation energy of the degradation reaction was evaluated as 40 kJ mol-1. A phenomenological kinetic mechanism is proposed to describe the reaction at a molecular scale. Finally, statistical validations and residuals analysis have been performed to confirm that the first order model is suitable to represent the 4-NP photocatalytic degradation over time. Such studies are essential to design a reactor for water pollutant degradation on an industrial scale. [less ▲]

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See detailExperimental investigation and phenomenological modeling of the quasi-static mechanical behavior of TA6V titanium alloy
Gilles, Gaëtan ULg; Habraken, Anne ULg; Duchene, Laurent ULg

in Key Engineering Materials [=KEM] (2014), 622-623

This paper proposes an experimental and numerical investigation of the quasi-static mechanical behavior of TA6V at room temperature. Different loading conditions ( tension, compression, plane strain ans ... [more ▼]

This paper proposes an experimental and numerical investigation of the quasi-static mechanical behavior of TA6V at room temperature. Different loading conditions ( tension, compression, plane strain ans simple shear) were applied on a 0.6 mm thick sheet in several in plane directions. Based on the experimental results, several identifications are performed to determinate the parameters involved in the CPB06 yield criterion and its extensions. The error/time computation ratio for the different identifications is next analysed to fix the choice of the yield criterion. The latter is finally associated with an isotropic hardening law on the one side and a formulation taking into account the evolution of the yield locus on the other side in order to describe the material. The ability of the proposed formulations to predict the TA6V response is studied int he case of a deep-drawing process. [less ▲]

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See detailSarcopénie. Quoi de neuf en 2014 ?
Beaudart, Charlotte ULg; GILLAIN, Sophie ULg; Petermans, Jean ULg et al

in Revue Médicale de Liège (2014), 69(5-6), 251-257

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See detailDeletion of exons 1-3 of the MEN1 gene in a large Italian family causes the loss of menin expression.
Zatelli, Maria Chiara; Tagliati, Federico; Di Ruvo, Mauro et al

in Familial cancer (2014)

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to ... [more ▼]

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to inactivating mutations of the MEN1 gene (chromosome 11q13). MEN1 mutations are mainly represented by nonsense, deletions/insertions, splice site or missense mutations that can be detected by direct sequencing of genomic DNA. However, MEN1 patients with large heterozygous deletions may escape classical genetic screening and may be misidentified as phenocopies, thereby hindering proper clinical surveillance. We employed a real-time polymerase chain reaction application, the TaqMan copy number variation assay, to evaluate a family in which we failed to identify an MEN1 mutation by direct sequencing, despite a clear clinical diagnosis of MEN1 syndrome. Using the TaqMan copy number variation assay we identified a large deletion of the MEN1 gene involving exons 1 and 2, in three affected family members, but not in the other nine family members that were to date clinically unaffected. The same genetic alteration was not found in a group of ten unaffected subjects, without family history of endocrine tumors. The MEN1 deletion was further confirmed by multiplex ligation-dependent probe amplification, which showed the deletion extended from exon 1 to exon 3. This new approach allowed us to correctly genetically diagnose three clinical MEN1 patients that were previously considered as MEN1 phenocopies. More importantly, we excluded the presence of genetic alterations in the unaffected family members. These results underline the importance of using a variety of available biotechnology approaches when pursuing a genetic diagnosis in a clinically suggestive setting of inherited endocrine cancer. [less ▲]

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See detailCan faecal markers detect a short term reduction in forage intake by cattle?
Benvenutti, Marcelo A.; Coates, David B.; Bindelle, Jérôme ULg et al

in Animal Feed Science & Technology (2014), 194

Detection of a reduction in forage intake is particularly relevant in grazing animals due to its negative effect on animal performance. Estimations of intake reduction using faecal markers can be ... [more ▼]

Detection of a reduction in forage intake is particularly relevant in grazing animals due to its negative effect on animal performance. Estimations of intake reduction using faecal markers can be inaccurate due to the time delay between a change in forage intake and the subsequent change in faecal output. This delay may vary depending on forage quality and marker type. A pen study was conducted for 29 days to test the efficacy of liquid (PEG = polyethylene glycol) and solid (alkanes and CrCl3 = chromium chloride) phase faecal markers to detect a reduction in intake by steers of diets that varied in forage quality. Ten Brahman cross steers (296 ± 16 kg) were allocated equally to diets of leafy, high quality buffel grass (Cenchrus ciliaris) hay and stemmy, low quality buffel grass hay. Hay was offered ad libitum from day 1 to 7, at 90% of voluntary intake from day 8 to 14 and then reduced by 8% each day from day 15 to 24. On day 5 each steer was dosed with two slow release alkane capsules; also, steers received a single daily dose of PEG and CrCl3 at 09:00 on days 5 to 24. Actual and marker derived estimates of forage intake over days 10 to 22 were assessed by repeated-measures analysis of variance. Overall marker recovery rates were satisfactory (0.92 to 1.03) and there was a significant (P < 0.001) progressive decrease in daily recovery rate over time for all markers and diets. Actual and marker-determined forage intake declined over the course of the experiment for both leafy and stemmy hay diets (P < 0.001) for all three markers. There was a lag of 3 to 5 days to detect a significant reduction in estimated intake by steers using markers. The lag period was similar for both liquid and solid phase markers. Results of this experiment indicated that decreases in forage intake by cattle could be detected using indigestible faecal markers, albeit in association with (i) progressively larger reductions in actual forage intake, and (ii) a time lag of 3 to 5 days between the decrease in actual intake and its statistical detection using faecal markers. [less ▲]

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See detailAphid honeydew: An arrestant and a contact kairomone for Episyrphus balteatus (Diptera: Syrphidae) larvae and adults
Leroy, Pascal; Almohamad, Raki; Attia, Sabrine et al

in European Journal of Entomology (2014), 111(2), 237-242

Predator searching efficiency increases in response to a variety of environmental cues associated with its prey. The sugary excretion of aphids (honeydew) has been found to act as a prey-associated cue ... [more ▼]

Predator searching efficiency increases in response to a variety of environmental cues associated with its prey. The sugary excretion of aphids (honeydew) has been found to act as a prey-associated cue for many aphid natural enemies. In the present study, the honeydew excreted by Acyrthosiphon pisum (Harris) was identified as an arrestant and a contact kairomone for young larvae and adults of a common predatory hoverfly, Episyrphus balteatus (De Geer) (Diptera: Syrphidae). First and second instar larvae increased their foraging behaviour in the honeydew-treated area. When plants were sprayed with crude honeydew, the speed of movement of female E. balteatus was significantly higher than in controls, resulting in a longer period of time spent on treated plants and laying eggs. We conclude that the honeydew excreted by A. pisum induces searching behaviour and acts as and arrestant not only for adults but also for young E. balteatus larvae. [less ▲]

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See detailVisual neglect: Is there a relationship between impaired spatial working memory and re-cancellation?
Wansard, Murielle ULg; Meulemans, Thierry ULg; Gillet, Sophie ULg et al

in Experimental Brain Research (2014)

In visual search tasks, neglect patients tend to explore and repeatedly re-cancel stimuli on the ipsilesional side, as if they did not realize that they had previously examined the rightward locations ... [more ▼]

In visual search tasks, neglect patients tend to explore and repeatedly re-cancel stimuli on the ipsilesional side, as if they did not realize that they had previously examined the rightward locations favoured by their lateral bias. The aim of this study was to explore the hypothesis that a spatial working memory deficit explains these ipsilesional re-cancellation errors in neglect patients. For the first time, we evaluated spatial working memory and re-cancellation through separate and independent tasks in a group of patients with right hemisphere damage and a diagnosis of left neglect. Results showed impaired spatial working memory in neglect patients. Compared to the control group, neglect patients cancelled fewer targets and made more re-cancellations both on the left side and on the right side. The spatial working memory deficit appears to be related to re-cancellations, but only for some neglect patients. Alternative interpretations of re-exploration of space are discussed. [less ▲]

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See detailAntioxidant Activity of Compounds Isolated from the Root Woods of Erythrina droogmansiana
Yaya, AJG; Feumba, RD; Emmanuel, T et al

in International Journal of Pharmaceutical Sciences and Drug Research (2014), 6(2), 160-163

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract ... [more ▼]

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract and isolated compounds. The phytochemical study led to the isolation of 3-(3’,4’-methelenedioxyphenyl)-2,3-epoxypropanol (1), asperphenamate (2) and three flavonoids namely genistein, diadzein and 4’,5,7-trihydroxy-8-prenylisoflavone. These compounds were characterized using their 1H NMR, 13C NMR, HMBC, HSQC, COSY, mass spectral and the literature. To evaluate antioxidant activity of crude extract and isolated compounds, the radical scavenging (DPPH) and Ferric Reducing Ability Power (FRAP) were performed using ascorbic acid as standard. Compounds 1 and 2 showed moderate radical scavenging potential with IC50 value of 3.14 and 3.31 mg/ml respectively, and moderate reducing power ability with value of 0.14±0.01 mgAAE/mg and 0.21±0.01 mgAAE/mg respectively. The more active compound was genistein (3) with IC50 value of 1.96 mg/ml for the DPPH radical scavenging potential and 0.24±0.02 mgAAE/mg for its ability to reduce iron. [less ▲]

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See detailRecommadantions européennes concernant la thérapie de resynchronisation cardiaque
ROBINET, Sébastien ULg; DELCOUR, Alexandre ULg; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2014), 69(4), 180-187

La thérapie de resynchronisation cardiaque (CRT) est l'une des plus grandes avancées thérapeutiques depuis ces 25 dernières années dans le domaine de l'insuffisance cardiaque. Elle est applicable chez ... [more ▼]

La thérapie de resynchronisation cardiaque (CRT) est l'une des plus grandes avancées thérapeutiques depuis ces 25 dernières années dans le domaine de l'insuffisance cardiaque. Elle est applicable chez plus de 25-30% des patients décompensés cardiaques symptomatiques. Dans cet article, nous détaillons les recommandations de la Société Européenne de Cardiologie 2013 concernant la thérapie de resynchronisation cardiaque. [less ▲]

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See detailEffect of the kinematic hardening in the simulations of the straightening of long rolled profiles
Bouffioux, Chantal ULg; Boman, Romain ULg; Caillet, Nicolas et al

in Key Engineering Materials [=KEM] (2014), 611-612

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are ... [more ▼]

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are straightened using a series of rollers placed alternately above and below the pieces with shifts which create a succession of bendings. The process is modeled to study the impact of the industrial parameters ( the duration of the cooling and the rollers positions), to improve the final geometry and to reduce the residual stresses.Tests are carried out on this structural steel to observe the material behavior, then material laws are chosen and parameters of these laws are defined using and inverse method. Two sets of material data are obtained: for the first one, the hardening is supposed to be isotropic, and for the second one, additional tests are performed to describe isotropic and kinematic hardenings.The cooling followed by the straightening is then simulated by the finite element with these two sets of date. The comparison of the rollers forces, the deformation and the residual stresses show the impact of the kinematic hardening on such a process where the material undergoes a sucession of the tensions and compressions. The real forces applied by the rollers,the real curvature of the interlocks at the end of the straightening process and the distribution of the residual longitudinal stresses measured on the web using the ring core method are used to validate the numerical model. [less ▲]

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See detailLe rôle de l’entourage au sein de l’hôpital africain : une thématique négligée ?
Schnitzler, Marie ULg

in Sciences Sociales et Santé (2014), 32(1), 39-64

En mobilisant le cadre théorique interactionniste pensé par Strauss (1992), cet article décrit les différentes tâches effectuées par l’entourage du malade dans un hôpital béninois afin de montrer comment ... [more ▼]

En mobilisant le cadre théorique interactionniste pensé par Strauss (1992), cet article décrit les différentes tâches effectuées par l’entourage du malade dans un hôpital béninois afin de montrer comment ce travail réalisé gratuitement par des travailleurs profanes favorise le fonctionnement au jour le jour de la structure. Les concepts d’« intermédiation » et de « dépendance » permettent de saisir les contraintes familiales exercées sur le patient en plus du contrôle médical. En conclusion, cet article prône le développement d’études sur les garde-malades pour renouveler les recherches sur la relation thérapeutique et sur l’organisation hospitalière en Afrique de l’Ouest. [less ▲]

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See detailAs Above, so Below: Narrative Salience and Side Effects of National Innovation Systems
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Critical Policy Studies (2014), accepté à publication

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See detailCompte-rendu de l'ouvrage de Eilene Powell et al.: La novela sugestiva
Ceballos Viro, Alvaro ULg

in Iberoamericana America Latina-Espana-Portugal (2014), (53), 218-220

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See detailValidation of real-time PCR for detection of six major pathogens in seafood products
Taminiau, Bernard ULg; Korsak Koulagenko, Nicolas ULg; Lemaire et al

in Food Control (2014), 44

Seafood can pose a public health concern to consumers. It is often consumed rawand may be contaminated with several foodborne pathogens. In order to guarantee the safety of seafood, real-time polymerase ... [more ▼]

Seafood can pose a public health concern to consumers. It is often consumed rawand may be contaminated with several foodborne pathogens. In order to guarantee the safety of seafood, real-time polymerase chain reaction (PCR) protocols may be used as these enable results to be provided within 24 h. The first goal of our work was to develop real-time PCR protocols enabling the detection of six foodborne pathogens that may be present in seafood products (Campylobacter jejuni, Campylobacter coli, enterohemorrhagic Escherichia coli, Salmonella spp., Vibrio parahaemolyticus, and Vibrio vulnificus). The corresponding gene targets were: 50S/VS1, rfbE, ttr, tlh, and vvp. A multiplex PCR was also developed to detect the virulence genes of V. parahaemolyticus: tdh and trh. A total of 420 bacterial strains belonging to four different genera/strains were used in this study. Sensitivity and specificity were always 100%, except in the case of Salmonella spp., where three strains were not detected by our PCR protocols. The second objective of our work was to assess the detection limit of our real-time PCR protocols on artificially contaminated seafood products (raw shrimps, cooked shrimps, and raw mussels), purchased in public stores. Six different levels of contamination were assayed in four replicates for each matrix. The real-time PCR protocols enabled a better level of detection than the ISO methods, except for Salmonella in raw shrimps and for V. vulnificus in shrimps (raw and cooked). The estimated level of detection was between 1 and 47 cfu/25 g sample for the ISO norms and between 1 and 315 cfu/25 g sample for the realtime PCR protocols tailored in our work. The real-time PCRs developed in our work allowed for good selectivity, sensitivity, and specificity. The sensitivity on seafood products was estimated at a level of 100%, except for Salmonella (97%). In the spiking assays, the levels of detection were lower with the real-time PCR protocol than those obtained with the ISO method. This was not the case for V. vulnificus in raw and cooked shrimps and for Salmonella in raw shrimps. These real-time PCR protocols appear to be good alternative methods for surveillance of seafood products to ensure the absence of foodborne pathogens. One additional conclusion is that laboratories have to use enrichment media that are compatible with those recommended by ISO standards. This may facilitate the isolation of the pathogen if the real-time PCR protocol gives a suspect positive signal during the first step of the seafood analysis. [less ▲]

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See detailTRAITEMENT CONSERVATEUR DES CANCERS INFILTRANTS DE LA VESSIE
WERENNE, Xavier ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 69-74

Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement ... [more ▼]

Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement «standard» des cancers infiltrants de la vessie. Cependant, elle est liée à un taux élevé de complications et à une altération de la qualité de vie, en particulier, chez les patients âgés présentant de nombreuses comorbidités. Le but de cet article est de déterminer les alternatives conservatrices et de préciser à quels patients elles doivent être réservées, en particulier, l’approche trimodale (résection trans-uréthrale et radio-chimiothérapie) et la cystectomie partielle précédée de radio-chimiothérapie [less ▲]

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See detailNonlinear Schrödinger wave equation with linear quantum behavior
Richardson, Christopher ULg; Schlagheck, Peter ULg; Martin, John ULg et al

in Physical Review. A (2014), 89

We show that a nonlinear Schro ̈dinger wave equation can reproduce all the features of linear quantum mechanics. This nonlinear wave equation is obtained by exploring, in a uniform language, the ... [more ▼]

We show that a nonlinear Schro ̈dinger wave equation can reproduce all the features of linear quantum mechanics. This nonlinear wave equation is obtained by exploring, in a uniform language, the transition from fully classical theory governed by a nonlinear classical wave equation to quantum theory. The classical wave equation includes a nonlinear classicality enforcing potential which when eliminated transforms the wave equation into the linear Schro ̈dinger equation. We show that it is not necessary to completely cancel this nonlinearity to recover the linear behavior of quantum mechanics. Scaling the classicality enforcing potential is sufficient to have quantumlike features appear and is equivalent to scaling Planck’s constant. [less ▲]

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See detailQuantification of HTLV-1 Clonality and TCR Diversity.
Laydon, Daniel J.; Melamed, Anat; Sim, Aaron et al

in PLoS computational biology (2014), 10(6), 1003646

Estimation of immunological and microbiological diversity is vital to our understanding of infection and the immune response. For instance, what is the diversity of the T cell repertoire? These questions ... [more ▼]

Estimation of immunological and microbiological diversity is vital to our understanding of infection and the immune response. For instance, what is the diversity of the T cell repertoire? These questions are partially addressed by high-throughput sequencing techniques that enable identification of immunological and microbiological "species" in a sample. Estimators of the number of unseen species are needed to estimate population diversity from sample diversity. Here we test five widely used non-parametric estimators, and develop and validate a novel method, DivE, to estimate species richness and distribution. We used three independent datasets: (i) viral populations from subjects infected with human T-lymphotropic virus type 1; (ii) T cell antigen receptor clonotype repertoires; and (iii) microbial data from infant faecal samples. When applied to datasets with rarefaction curves that did not plateau, existing estimators systematically increased with sample size. In contrast, DivE consistently and accurately estimated diversity for all datasets. We identify conditions that limit the application of DivE. We also show that DivE can be used to accurately estimate the underlying population frequency distribution. We have developed a novel method that is significantly more accurate than commonly used biodiversity estimators in microbiological and immunological populations. [less ▲]

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See detailScreening for malnutrition in lung cancer patients undergoing therapy
BARTHELEMY, Nicole ULg; Streel, Sylvie ULg; Donneau, Anne-Françoise ULg et al

in Supportive Care in Cancer (2014), 22(6), 15311536

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See detailA New Look at Ichthyosaur Long Bone Microanatomy and Histology: Implications for Their Adaptation to an Aquatic Life
Houssaye, Alexandra; Scheyer, Torsten; Kolb, Christian et al

in PLoS ONE (2014), 9(4), 95637

Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades ... [more ▼]

Background Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades. Data concerning their bone microanatomical and histological features are rather limited and suggest that ichthyosaurs display a spongious, “osteoporotic-like” bone inner structure, like extant cetaceans. However, some taxa exhibit peculiar features, suggesting that the analysis of the microanatomical and histological characteristics of various ichthyosaur long bones should match the anatomical diversity and provide information about their diverse locomotor abilities and physiology. Methodology/Principal Findings The material analyzed for this study essentially consists of mid-diaphyseal transverse sections from stylopod bones of various ichthyosaurs and of a few microtomographic (both conventional and synchrotron) data. The present contribution discusses the histological and microanatomical variation observed within ichthyosaurs and the peculiarities of some taxa (Mixosaurus, Pessopteryx). Four microanatomical types are described. If Mixosaurus sections differ from those of the other taxa analyzed, the other microanatomical types, characterized by the relative proportion of compact and loose spongiosa of periosteal and endochondral origin respectively, seem to rather especially illustrate variation along the diaphysis in taxa with similar microanatomical features. Our analysis also reveals that primary bone in all the ichthyosaur taxa sampled (to the possible exception of Mixosaurus) is spongy in origin, that cyclical growth is a common pattern among ichthyosaurs, and confirms the previous assumptions of high growth rates in ichthyosaurs. Conclusions/Significance The occurrence of two types of remodelling patterns along the diaphysis, characterized by bone mass decrease and increase respectively is described for the first time. It raises questions about the definition of the osseous microanatomical specializations bone mass increase and osteoporosis, notably based on the processes involved, and reveals the difficulty in determining the true occurrence of these osseous specializations in ichthyosaurs. [less ▲]

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See detailComplex dynamics of a nonlinear aerospace structure: experimental identification and modal interactions
Noël, Jean-Philippe ULg; Renson, Ludovic ULg; Kerschen, Gaëtan ULg

in Journal of Sound & Vibration (2014), 333

Nonlinear system identification is a challenging task in view of the complexity and wide variety of nonlinear phenomena. The present paper addresses the identification of a real-life aerospace structure ... [more ▼]

Nonlinear system identification is a challenging task in view of the complexity and wide variety of nonlinear phenomena. The present paper addresses the identification of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. The complete identification procedure, from nonlinearity detection and characterization to parameter estimation, is carried out based upon experimental data. The combined use of various analysis techniques, such as the wavelet transform and the restoring force surface method, brings different perspectives to the dynamics. Specifically, the structure is shown to exhibit particularly interesting nonlinear behaviors, including jumps, modal interactions, force relaxation and chattering during impacts on the mechanical stops. [less ▲]

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See detailDecrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.
Henrotin, Yves; Henrotin, Yves ULg

in BMC Complimentary & Alternative Medicine (2014)

The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring ... [more ▼]

The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring both disease activity and treatment efficacy. Curcumin is basically a spice that is known for its anti-inflammatory properties. In vitro studies suggest that curcumin could be beneficial for cartilage in OA. The aim of this exploratory, non-controlled clinical trial was to evaluate the effects of bio-optimized curcumin in knee OA patients on the serum levels of specific biomarkers of OA and on the evaluation of pain. This study highlighted the potential effect of curcumin in knee OA patient. This effect was reflected by the variation of a cartilage specific biomarker, Coll2-1 that was rapidly affected by the treatment. These results are encouraging for the qualification of Coll2-1 as a biomarker for the evaluation of curcumin in OA treatment. (Trial registration: NCT01909037 at clinicaltrials.gov) [less ▲]

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See detailEffect of gamma-hydroxybutyrate on keratinocytes proliferation: a preliminary prospective controlled study in severe burn patients.
ROUSSEAU, Anne-Françoise ULg; BARGUES, Laurent; LE BEVER, Hervé et al

in International Journal of Critical Illness and Injury Science (2014), 4(2), 108-113

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See detailGas dissolution in antibubble dynamics
scheid, benoit; zawala, jan; Dorbolo, Stéphane ULg

in Soft Matter (2014), 10

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See detailA new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms
Sacre, Pierre-Yves ULg; Lebrun, Pierre ULg; Chavez, Pierre-François ULg et al

in Analytica Chimica Acta (2014), 818

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of ... [more ▼]

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of choice for assessing the distributional homogeneity of compounds of interest. Indeed, the combination of both spectroscopic and spatial information provides a detailed knowledge of chemical composition and component distribution. Actually, most authors assess homogeneity using parameters of the histogram of intensities (e.g. mean, skewness and kurtosis). However, this approach does not take into account spatial information and loses the main advantage of imaging. To overcome this limitation, we propose a new criterion: Distributional Homogeneity Index (DHI). DHI has been tested on simulated maps and formulation development samples. The distribution maps of the samples were obtained without validated calibration model since different formulations were under investigation. The results obtained showed a linear relationship between content uniformity values and DHI values of distribution maps. Therefore, DHI methodology appears to be a suitable tool for the analysis of homogeneity of distribution maps even without calibration during formulation development. [less ▲]

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See detailReview of Postcolonial Ecologies: Literatures of the Environment edited by Elizabeth DeLoughrey and George B. Handley
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2014), 88(1-2), 182-184

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See detailQuelles dynamiques d'identification organisationnelle lors de processus de modernisation? Analyse d'une administration belge.
Rondeaux, Giseline ULg

in Revue Internationale des Sciences Administratives [= RISA] (2014), 80(mars), 110-130

In the course of reform, organizational identity emerges as a prominent issue. While the process of modernizing the administration sets out to redefine this identity, how is this experienced by its ... [more ▼]

In the course of reform, organizational identity emerges as a prominent issue. While the process of modernizing the administration sets out to redefine this identity, how is this experienced by its members? What are the identity dynamics at work in terms of their perception of changes in their environment? By analysing the Copernic reform in Belgium, we inductively developed a typology of identity rationales and profiles (Rondeaux, 2006, 2007, 2008, 2010). On this basis, we conducted a questionnaire survey in a regional administration engaged in reform. Our analysis highlights the coexistence of different identity rationales and diverse perceptions of the environment, which are congruent or dissonant with them. The results underline the importance of the environment and of its perception in organizational identification processes and confirms the hypothesis of identity hybridization, providing also an empirical basis for the integrative approach of Ravasi and Schultz (2006). [less ▲]

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See detailThe anagenetic world of spore-producing land plants
Patino Llorente, Jairo ULg; Carine, M.A.; Fernández-Palacios, J.M. et al

in New Phytologist (2014), 201

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See detailSimultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry
Dewalque, Lucas ULg; PIRARD, Catherine ULg; DUBOIS, Nathalie ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2014), 949-950

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to ... [more ▼]

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to some hormonal diseases. Numerous large-scale biomonitoring studies have detected the biomarkers of these compounds in more than 75% of the general population. To assess the exposure to these chemicals, we developed an analytical method based on a Solid Phase Extraction (SPE) prior to ultra high pressure liquid chromatographytandem mass spectrometry (UPLC-MS/MS) for the simultaneous measurement of seven phthalate metabolites (monobenzyl phthalate, mono-n-butyl phthalate, mono-iso-butyl phthalate, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2- ethyl-5-oxohexyl phthalate, monoethyl phthalate), four parabens (methyl paraben, ethyl paraben, n-propyl paraben, n-butyl parabens) and benzophenone-3 in human urine. The distinction between unconjugated, glucuro- and sulfoconjugated forms was achieved using different enzymatic hydrolyses. The whole procedure was validated according to the total error approach, and was demonstrated to be linear (regression coefficient ranging from 0.987 to 0.998) and accurate (inter and intra assay precision <17.71%, relative bias <5.87%) in the dosing range of concentrations. The limits of quantification (LOQs) obtained ranged between 0.30 and 1.23 ng/ml depending on the analyte. The reliability of the method was proven in passing successfully the German External Quality Assessment Scheme (G-EQUAS). Moreover, the urine from 25 volunteers were analyzed for the determination of glucuro-, sulfo- and free species separately. Phthalate metabolites, parabens and benzophenone-3 were positively detected in almost all urine samples, with detection rates ranging from 40 to 100%. Levels measured ranged from <LOQ to 2207 ng/ml varying widely depending on the compound and the individual. In our small participating population, most of the phthalate metabolites were excreted predominately as glucuroconjugated forms while parabens and benzophenone-3 were detected as glucuro- and sulfoconjugated species in variable proportions according to the target compound. [less ▲]

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See detailThe mitochondrial respiratory chain of the secondary green alga Euglena gracilis shares many additional subunits with parasitic Trypanosomatidae.
Perez, Emilie ULg; Lapaille, Marie; Degand, Herve et al

in Mitochondrion (2014)

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential ... [more ▼]

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential therapeutic target. Recently, numerous additional subunits of the respiratory-chain complexes have been described in Trypanosoma brucei and Trypanosoma cruzi. Since these subunits had apparently no counterparts in other organisms, they were interpreted as potentially associated with the parasitic trypanosome lifestyle. Here we used two complementary approaches to characterise the subunit composition of respiratory complexes in Euglena gracilis, a non-parasitic secondary green alga related to trypanosomes. First, we developed a phylogenetic pipeline aimed at mining sequence databases for identifying homologs to known respiratory-complex subunits with high confidence. Second, we used MS/MS proteomics after two-dimensional separation of the respiratory complexes by Blue Native- and SDS-PAGE to both confirm in silico predictions and to identify further additional subunits. Altogether, we identified 41 subunits that are restricted to E. gracilis, T. brucei and T. cruzi, along with 48 classical subunits described in other eukaryotes (i.e. plants, mammals and fungi). This moreover demonstrates that at least half of the subunits recently reported in T. brucei and T. cruzi are actually not specific to Trypanosomatidae, but extend at least to other Euglenozoa, and that their origin and function are thus not specifically associated with the parasitic lifestyle. Furthermore, preliminary biochemical analyses suggest that some of these additional subunits underlie the peculiarities of the respiratory chain observed in Euglenozoa. [less ▲]

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See detailA Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish
Genon, Sarah ULg; Bastin, Christine ULg; Angel, Lucie et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 54

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See detailIron loss calculation in steel laminations at high frequencies
Henrotte, François; Steentjes, Simon; Hameyer, Kay et al

in IEEE Transactions on Magnetics (2014), 50(2), 333-336

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See detailNormal reference ranges for echocardiography: do we really need more?
Lancellotti, Patrizio ULg

in European heart journal cardiovascular Imaging (2014), 15(3), 253-4

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See detailLa conscience et la mort. Le premier Sartre, Bergson, Freud et Ferenczi
Cormann, Grégory ULg

in Etudes Sartriennes (2014), 17

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See detailSocial Security and Family Support
Leroux, Marie Louise; Pestieau, Pierre ULg

in Canadian Journal of Economics (2014), 47(1), 115-143

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See detailStructural, magnetic and magneto-transport properties of monovalent doped manganite Pr0.55K0.05Sr0.4MnO3
Thaljaoui, R.; Boujelben, W.; Pękała, M. et al

in Journal of Alloys and Compounds (2014), 611(0), 427-432

Pr0.55K0.05Sr0.4MnO3 sample have been synthesized using the conventional solid state reaction. Rietveld refinements of the X-ray diffraction patterns at room temperature confirm that the sample is single ... [more ▼]

Pr0.55K0.05Sr0.4MnO3 sample have been synthesized using the conventional solid state reaction. Rietveld refinements of the X-ray diffraction patterns at room temperature confirm that the sample is single phase and crystallizes in the orthorhombic structure with Pnma space group; the crystallite size is around 70 nm. The SEM images show that grain size spreads around 1000–1200 nm. DTA analysis does not reveal any clear transition in temperature range studied. The low-temperature DSC indicates that Curie temperature is around 297 K. Magnetization measurements in a magnetic applied field of 0.01 T exhibit a paramagnetic–ferromagnetic transition at the Curie temperature TC = 303 K. A magnetic entropy change under an applied magnetic field of 2 T is found to be 2.26 J kg−1 K−1, resulting in a large relative cooling power around 70 J/kg. Electrical resistivity measurements reveal a transition from semiconductor to metallic phase. The thermal conductivity is found to be higher than that reported for undoped and Na doped manganites reported by Thaljaoui et al. (2013). [less ▲]

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See detailEtudes des propriétés psychométriques de la CES-D sur un échantillon d'adolescents francophones scolarisés
Boulard, Aurore ULg; Gauthier, Jean-Marie ULg; Born, Michel ULg

in L'Encéphale (2014), 40(2), 123-128

L’objectif de cet article est d’étudier et valider la version francaise de l’échelle de dépression Center for Epidemiologic Studies Depression Scale (CES-D) mise au point par Radloff (en 1977) dans une ... [more ▼]

L’objectif de cet article est d’étudier et valider la version francaise de l’échelle de dépression Center for Epidemiologic Studies Depression Scale (CES-D) mise au point par Radloff (en 1977) dans une population d’adolescents scolarisés. [less ▲]

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See detailAn online interactive tool to assess energy consumption in residential buildings and for daily mobility
Marique, Anne-Françoise ULg; de Meester, Tatiana; De Herde, André et al

in Energy and Buildings (2014), 78C

Improving energy efficiency in the building and transportation sectors is a viable approach to mitigate the effects of climate change and has become an important policy target. As a result, in addition to ... [more ▼]

Improving energy efficiency in the building and transportation sectors is a viable approach to mitigate the effects of climate change and has become an important policy target. As a result, in addition to scientific research and public policies addressing energy efficiency, raising public awareness of the impact of the behaviour of citizens to energy efficiency is crucial and could quickly lead to significant reductions in the total energy consumption of a territory. In this context, this paper presents a new online interactive tool that enables not only citizens but also local authorities and private developers to (1) assess the sources of energy consumption related to housing and to daily mobility at both the individual and neighbourhood scales, (2) compare these sources and (3) determine relevant and personalised suggestions to reduce energy consumption. Numerous methods and tools, including a typological classification of buildings, thermal dynamic simulations, life-cycle assessments and statistical treatments of national censuses, were used to produce the two large databases used in this interactive tool. This report represents the primary results of a three-year long scientific research project dedicated to the study of energy efficiency in buildings and for daily mobility that is accessible to a large non-specialised audience. [less ▲]

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See detailPAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Bajou, Khalid ULg; Herkenne, Stéphanie ULg; Thijssen, Victor L. et al

in Nature Medicine (2014), sous presse

The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor ... [more ▼]

The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor angiogenesis and growth. Loss of PAI-1 abrogated the antitumoral and antiangiogenic effects of 16K PRL. PAI-1 bound the ternary complex PAI-1-urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR), thereby exerting antiangiogenic effects. By inhibiting the antifibrinolytic activity of PAI-1, 16K PRL also protected mice against thromboembolism and promoted arterial clot lysis. Thus, by signaling through the PAI-1-uPA-uPAR complex, 16K PRL impairs tumor vascularization and growth and, by inhibiting the antifibrinolytic activity of PAI-1, promotes thrombolysis. [less ▲]

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See detailUn projet européen de recherche interventionnelle, pour quelle santé mentale ?
Fond-Harmant, Laurence; Absil, Gaëtan ULg

in Priorités Santé (2014), (39), 18-19

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See detailExternal constraints on optical control strategies in molecular orientation and photofragmentation: role of zero-area fields
Sugny, Dominique; Vranckx, Stéphane; Ndong, Mamadou et al

in Journal of Modern Optics (2014), 61

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See detailA 3-D Semi-Implicit Method for Computing the Current Density in Bulk Superconductors
Kameni, Abelin; Boubekeur, Mohamed; Alloui, Lotfi et al

in IEEE Transactions on Magnetics (2014), 50(2), 377--380

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See detailOn the policy implications of changing longevity
Pestieau, Pierre ULg; Ponthiere, Grégory ULg

in CESifo Ecoonmic Studies (2014), 60

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See detailDouble sweep preconditioner for optimized Schwarz methods applied to the Helmholtz problem
Vion, Alexandre ULg; Geuzaine, Christophe ULg

in Journal of Computational Physics (2014), 266

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See detailCan new information and communication technologies help in the management of osteoporosis ?
Slomian, Justine ULg; Appelboom, G; Ethgen, Olivier ULg et al

in Women's Health (2014), 10(3), 229-232

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See detailBlocking lipid synthesis overcomes tumor re-growth and metastasis after anti-angiogenic therapy withdrawal.
Sounni, Nor Eddine ULg; Cimino, Jonathan ULg; BLACHER, Silvia ULg et al

in Cell Metabolism (2014), 20

The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied transcriptomic, proteomic, and metabolomic approaches ... [more ▼]

The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied transcriptomic, proteomic, and metabolomic approaches to preclinical models and provide evidence for tumor adaptation to vascular endothelial growth factor blockade through a metabolic shift toward carbohydrate and lipid metabolism in tumors. During sunitinib or sorafenib treatment, tumor growth was inhibited and tumors were hypoxic and glycolytic. In sharp contrast, treatment withdrawal led to tumor regrowth, angiogenesis restoration, moderate lactate production, and enhanced lipid synthesis. This metabolic shift was associated with a drastic increase in metastatic dissemination. Interestingly, pharmacological lipogenesis inhibition with orlistat or fatty acid synthase downregulation with shRNA inhibited tumor regrowth and metastases after sunitinib treatment withdrawal. Our data shed light on metabolic alterations that result in cancer adaptation to antiangiogenic treatments and identify key molecules involved in lipid metabolism as putative therapeutic targets. [less ▲]

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See detailSeagrass amphipod assemblages in a Mediterranean marine protected area: a multiscale approach
Sturaro, Nicolas ULg; Lepoint, Gilles ULg; Pérez-Perera, Amanda et al

in Marine Ecology. Progress Series (2014), 506

Marine protected areas (MPAs) are a key tool for conservation purposes, but few studies have assessed the responses of small macrozoobenthic assemblages to different protection levels in the Mediterranean ... [more ▼]

Marine protected areas (MPAs) are a key tool for conservation purposes, but few studies have assessed the responses of small macrozoobenthic assemblages to different protection levels in the Mediterranean Sea. In this study, we used a hierarchical sampling design spanning three orders of magnitude (1-10-100 metres) to investigate whether a marine protected area exerts an effect on amphipod assemblages associated with Posidonia oceanica meadows. This study reports spatial and temporal variability patterns of amphipod assemblages in four different protection levels and discusses potential confounding effects, such as habitat features. The structure of amphipod assemblages based on density data was patchy at all spatial scales investigated, but differed markedly among protection levels. Among outstanding points, multiscale analyses showed that lower densities and/or biomasses of several taxa occurred within fully protected and external areas in comparison with partially protected areas (PPAs). Furthermore, Posidonia oceanica meadow features (shoot density, leaf and epiphyte biomasses, coefficient A and litter biomass) accounted for only a low proportion of the total variability. We can consequently infer that the observed patchiness is likely to occur for multiple and interconnected reasons, ranging from the ecological and behavioural traits of amphipod species to protection-dependent processes (e.g. fish predation). Long term multiscale spatial and temporal monitoring, as well as experimental manipulations, are clearly needed to fully understand the effects of protection on macrozoobenthic assemblages. [less ▲]

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See detailMary Anning’s legacy to French vertebrate palaeontology
Vincent, Peggy; Taquet, Philippe; Fischer, Valentin ULg et al

in Geological Magazine (2014), 151(1), 7-20

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent ... [more ▼]

The real nature of marine reptile fossils found in England in between the 1700s to the beginning of the 1900s remained enigmatic, until Mary Anning's incredible fossil discoveries and their subsequent study by eminent English and French scientists. In 1820, Georges Cuvier acquired several ichthyosaur specimens found by Mary Anning, now kept or displayed in the Palaeontology Gallery of the MNHN in Paris. Four years later, Cuvier obtained a plesiosaur specimen from Mary Anning, only the second ever discovered. Cuvier was fascinated by these fossils and their study allowed him to apply his comparative anatomical method and to support his catastrophist theory. We re-examined these important specimens from an historical point of view and herein describe them taxonomically for the first time since Cuvier’s works. The Paris specimens belong to two different ichthyosaur genera (Ichthyosaurus and Leptonectes) and one plesiosaur genus (Plesiosaurus). [less ▲]

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See detailMonte-Cristo chimiste et physicien des communications : du télégraphe optique au télégraphe électrique
Durand, Pascal ULg

in Cahiers Alexandre Dumas (2014), 41

La scène du télégraphe optique, dans Le Comte de Monte-Cristo, aide à mettre en lumière la modernité du roman. Cette modernité tient pour une part à une ligne de continuité établie entre chronique ... [more ▼]

La scène du télégraphe optique, dans Le Comte de Monte-Cristo, aide à mettre en lumière la modernité du roman. Cette modernité tient pour une part à une ligne de continuité établie entre chronique judiciaire et fable romanesque, sur fond de réseau télégraphique. Elle tient plus encore au fait que cet épisode du télégraphe rend singulièrement visible l’allégorie de la communication que le roman développe à différents niveaux de sa construction narrative, allant de son incipit très sémiologique à la « voile blanche » qui signalera sur fond d’azur méditerranéen, quatorze cents pages plus loin, le départ d’un Monte-Cristo ayant recouvré son identité perdue, en passant par les deux figures successivement incarnées par son héros, dépeint en victime sacrificielle puis en expert d’une communication dont il saura jouer de tous les ressorts — rapidité de déplacement, contrôle de l’information, maîtrise des formes spéculatives et fiduciaires de l’économie, dévoiement des formes anthropologiques de l’échange social, etc. — pour l’emporter finalement sur les trois pouvoirs coalisés de la Politique (Morcerf), de la Justice (Villefort) et de la Banque (Danglars) ; tout cela orchestré par une triple métaphore du sang, de l’argent et de l’information, dont la signification réversible ne peut être séparée d’une doctrine saint-simonienne que Dumas à la fois relaie et révoque. De même que le couloir de communication établi au château d’If entre la cellule de Dantès et celle de Faria, la scène du télégraphe fait ainsi office de point de cristallisation d’une symbolique diffuse. Cette scène si cardinale, il s'agit ici de montrer qu’elle est non seulement grosse encore de tout un savoir à dimension technique autant qu’anthropologique, mais également porteuse, vers d’autres zones du roman, d’une assez étonnante préfiguration du télégraphe électrique, en cheville avec une modernité technique dont Dumas faufile les signes de façon plus ou moins cryptée dans la trame de son roman. [less ▲]

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See detailClick-Evoked Otoacoustic Emissions in Children and Adolescents with Gender Identity Disorder.
Burke, Sarah M.; Menks, Willeke M.; Cohen-Kettenis, Peggy T. et al

in Archives of sexual behavior (2014)

Click-evoked otoacoustic emissions (CEOAEs) are echo-like sounds that are produced by the inner ear in response to click-stimuli. CEOAEs generally have a higher amplitude in women compared to men and ... [more ▼]

Click-evoked otoacoustic emissions (CEOAEs) are echo-like sounds that are produced by the inner ear in response to click-stimuli. CEOAEs generally have a higher amplitude in women compared to men and neonates already show a similar sex difference in CEOAEs. Weaker responses in males are proposed to originate from elevated levels of testosterone during perinatal sexual differentiation. Therefore, CEOAEs may be used as a retrospective indicator of someone's perinatal androgen environment. Individuals diagnosed with Gender Identity Disorder (GID), according to DSM-IV-TR, are characterized by a strong identification with the other gender and discomfort about their natal sex. Although the etiology of GID is far from established, it is hypothesized that atypical levels of sex steroids during a critical period of sexual differentiation of the brain might play a role. In the present study, we compared CEOAEs in treatment-naive children and adolescents with early-onset GID (24 natal boys, 23 natal girls) and control subjects (65 boys, 62 girls). We replicated the sex difference in CEOAE response amplitude in the control group. This sex difference, however, was not present in the GID groups. Boys with GID showed stronger, more female-typical CEOAEs whereas girls with GID did not differ in emission strength compared to control girls. Based on the assumption that CEOAE amplitude can be seen as an index of relative androgen exposure, our results provide some evidence for the idea that boys with GID may have been exposed to lower amounts of androgen during early development in comparison to control boys. [less ▲]

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See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging: Part II.
Plein, Sven; Edvardsen, Thor; Pierard, Luc ULg et al

in European heart journal cardiovascular Imaging (2014)

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in ... [more ▼]

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in two articles. Part I of the review has summarized studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging. Part II is focussed on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

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See detailIndirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women.
Ellis, Alexandra G.; Reginster, Jean-Yves ULg; Luo, Xuemei et al

in Current medical research and opinion (2014), 30(8), 1617-1626

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on ... [more ▼]

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on evidence from randomized controlled trials (RCTs). Methods: Eight RCTs assessing vertebral fracture risk reduction with oral bisphosphonates (n = 7) or bazedoxifene (n = 1) were identified by a systematic literature review. Individual study results were pooled in a network meta-analysis (NMA) to indirectly compare treatment effects for overall PMO women and a higher-risk subgroup (FRAX >/= 20%). Three sets of NMA analyses were conducted: aggregate data (AD) from the bisphosphonate RCTs and bazedoxifene RCT for the full population or the FRAX >/=20% subgroup (NMA AD); bisphosphonate AD and bazedoxifene AD from each FRAX subgroup adjusted for baseline risk (NMA AD meta-regression); and bisphosphonate AD and bazedoxifene individual patient data (IPD) adjusted for baseline risk/FRAX (NMA AD/IPD meta-regression). Results: For the overall population, bisphosphonates had lower fracture risks versus bazedoxifene although there is considerable uncertainty in supporting one intervention over another. The relative risk reduction (RRR) for bazedoxifene was -0.23 (95% CrI: -1.11, 0.27) versus ibandronate, -0.17 (-0.76, 0.22) versus alendronate, and -0.06 (-0.62, 0.30) versus risedronate. Results from the meta-regression analyses were similar. For the FRAX >/=20% population, estimated fracture rates with bazedoxifene were lower than with bisphosphonates, but again the uncertainty limits strong interpretation. The RRR for bazedoxifene was 0.51 (-0.31, 0.83) versus ibandronate, 0.53 (-0.18, 0.83) versus alendronate, and 0.57 (-0.07, 0.85) versus risedronate. The meta-regression analyses showed comparable findings. Conclusion: The analyses only considered vertebral fractures for oral bisphosphonates versus bazedoxifene, and IPD was available only for bazedoxifene. In light of this, bazedoxifene is comparable to bisphosphonates in the overall PMO population and at least as effective as bisphosphonates for preventing vertebral fractures among higher-risk PMO patients. The findings suggest bazedoxifene performs better in higher-risk PMO than in the overall PMO. [less ▲]

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See detailAuditory hallucinations in persons with and without a need for care
Johns; Kompus, K; Connell, M et al

in Schizophrenia Bulletin (2014), 40

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See detailInfluence of the surface morphology of smooth platinum electrodes for the sodium borohydride oxidation reaction
Olu, Pierre-Yves; Gilles, Bruno; Job, Nathalie ULg et al

in Electrochemistry Communications (2014), 43

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See detailCriteria and tools for objectively analysing the vocal accuracy of a popular song
Larrouy, Pauline ULg; Morsomme, Dominique ULg

in Logopedics, Phoniatrics, Vocology (2014), 39

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt ... [more ▼]

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt and OpenMusic (Ircam, Paris, France). In terms of evaluation of the pitch interval deviation, we replicated the profile of occasional singers described in the literature (the slower the performance, the more accurate it is). Our results also confirm that the professional singers sing more accurately than occasional singers but not when a Western operatic singing technique is involved. These results support the relevance of our method for analysing vocal accuracy of occasional and professional singers and led us to discuss adaptations to be implemented for analysing the accuracy of operatic voices. [less ▲]

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See detailThe influence of equivalent contact area computation in extended node to surface contact elements
Wautelet, Gaëtan ULg; Ponthot, Jean-Philippe ULg

in Key Engineering Materials [=KEM] (2014), 618

This article aims at extending the node to surface formulation for contact problems with an area regularization as proposed by [1]. For that purpose, two methods are proposed to compute the equivalent ... [more ▼]

This article aims at extending the node to surface formulation for contact problems with an area regularization as proposed by [1]. For that purpose, two methods are proposed to compute the equivalent contact area attributed to each slave node. The first method, which is based on a geometrical approach through force equivalence, is an original extension of the one proposed in [1] for two-dimensional contact problems, i.e. plane stress and plane strain state, to the axisymmetric modelling context. The second method relies on an energy consistent way obtained through the virtual work principle and the same expression for the equivalent contact area as the one originally cited in [2] is then recovered. First, the node to surface strategy with area regularization is introduced and the aforementioned methods for the equivalent contact area are presented in detail and compared. Afterwards a consistent linearization technique is applied to achieve a quadratic convergence rate in the Newton Raphson iterative procedure used to solve the non-linear equilibrium equations of the underlying finite element model. Finally, two axisymmetric numerical examples are provided in order to compare the aforementioned equivalent contact area evaluations and to demonstrate the performance and the robustness of the consistent approach especially in the neighbourhood the revolution axis. [less ▲]

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See detailLateral Magnetic Near-Field Imaging of Plasmonic Nanoantennas With Increasing Complexity
Denkova, D.; Verellen, N.; Silhanek, Alejandro ULg et al

in Small : Nano Micro (2014)

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field ... [more ▼]

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field interactions between their building blocks. While the electric field distributions and, respectively, the electric interactions of different nanostructures can be routinely measured, for example, by scattering near-field microscopy, only recently experimental methods for imaging the magnetic field distributions became available. In this paper, we provide direct experimental maps of the lateral magnetic near-field distributions of variously shaped plasmonic nanoantennas by using hollow-pyramid aperture scanning near-field optical microscopy (SNOM). We study both simple plasmonic nanoresonators, such as bars, disks, rings and more complex antennas. For the studied structures, the magnetic near-field distributions of the complex resonators have been found to be a superposition of the magnetic near-fields of the individual constituting elements. These experimental results, explained and validated by numerical simulations, open new possibilities for engineering and characterization of complex plasmonic antennas with increased functionality. [less ▲]

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See detailA clinically novel AIP mutation in a patient with a very large, apparently sporadic somatotrope adenoma.
Salvatori, Roberto; Daly, Adrian ULg; Quinones-Hinojosa, Alfredo et al

in Endocrinology, diabetes & metabolism case reports (2014), 2014

Heterozygous germline inactivating mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene lead to pituitary adenomas that most frequently present in the setting of familial isolated ... [more ▼]

Heterozygous germline inactivating mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene lead to pituitary adenomas that most frequently present in the setting of familial isolated pituitary adenoma syndrome, usually as somatotropinomas and prolactinomas. More recently, they have been found in a significant percentage of young patients presenting with pituitary macroadenoma without any apparent family history. We describe the case of a 19-year-old man who presented with a gigantic somatotropinoma. His family history was negative. His peripheral DNA showed a heterozygous AIP mutation (p.I13N), while tumor tissue only had the mutated allele, showing loss of heterozygosity (LOH) and suggesting that the mutation caused the disease. LEARNING POINTS: AIP mutations may be observed in sporadic somatotrope adenomas occurring in young patients.LOH is a strong indicator that an AIP variant is disease causing.Somatotrope adenomas in carriers of AIP mutations are generally larger and more difficult to cure. [less ▲]

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See detailIdentification of 1-methyloctyl butanoate as the major sex pheromone component from females of the saddle gall midge, Haplodiplosis marginata (Diptera: Cecidomyiidae)
Censier, Florence ULg; Fischer, Christophe ULg; Pascal, Laurent et al

in Chemoecology (2014)

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective monitoring tool of saddle gall midge flights is needed in order to understand the enigmatic population dynamics of this pest, and to design an integrated management strategy. Therefore, volatile compounds emitted by females (alkan-2-ols and alk-2-yl butanoates) were identified, and the chirality of the emitted esters was determined to be the R absolute configuration. In field-trapping experiments, racemic non-2-yl butanoate attracted substantial numbers of H. marginata males. Thus, this compound will be useful in baited traps for monitoring seasonal flight patterns, and improving integrated management of the saddle gall midge in agricultural systems. [less ▲]

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See detailUrtica jacta est : quelques mots de la quatrième édition du concours facultaire de dissertation et d'éloquence
Deprez, Christophe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 1

Ce bref compte rendu évoque la quatrième édition du concours de dissertation et d'éloquence organisé par le personnel scientifique de la Faculté de droit, de science politique et de criminologie de l ... [more ▼]

Ce bref compte rendu évoque la quatrième édition du concours de dissertation et d'éloquence organisé par le personnel scientifique de la Faculté de droit, de science politique et de criminologie de l'Universté de Liège (2013-2014). [less ▲]

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See detailLA PHYSIQUE DES RADIATIONS IONISANTES POUR LES NEOPHYTES
LENAERTS, Eric ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 13-15

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès ... [more ▼]

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès majeurs en radiothérapie, visant à l’op - timisation de la distribution de la dose sur la cible et à l’exclu - sion, dans la mesure du possible, de l’irradiation des tissus sains avoisinants. Le développement de nouvelles modalités de traitement, telle l’utilisation des hadrons, est le reflet du développement de cette science. Aux confins de cette radio- physique se trouve la radiobiologie, et l’ensemble des connais - sances dans ces deux domaines permet une optimisation de la prescription médicale [less ▲]

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See detailFlexible estimation in cure survival models using Bayesian P-splines
Bremhorst, Vincent; Lambert, Philippe ULg

in Computational Statistics & Data Analysis (2014)

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an ... [more ▼]

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an unknown proportion of the population under study will never experience the monitored event. The promotion time model, which has a biological motivation, is one of the survival models taking this feature into account. The promotion time model assumes that the failure time of each subject is generated by the minimum of N independent latent event times with a common distribution independent of N. An extension which allows the covariates to influence simultane- ously the probability of being cured and the latent distribution is presented. The latent distribution is estimated using a flexible Cox proportional hazard model where the logarithm of the baseline hazard function is specified using Bayesian P-splines. Introducing covariates in the latent distribution implies that the population hazard function might not have a proportional hazard structure. However, the use of P- splines provides a smooth estimation of the population hazard ratio over time. The identification issues of the model are discussed and a restricted use of the model when the follow up of the study is not sufficiently long is proposed. The accuracy of our methodology is evaluated through a simulation study and the model is illustrated on data from a Melanoma clinical trial. [less ▲]

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See detailCompte rendu de Eugen AFONASIN, John DILLON & John FINAMORE (eds.), "Iamblichus and the Foundations of Late Platonism"
Gavray, Marc-Antoine ULg

in Revue Philosophique de Louvain (2014), 112(1), 167-169

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See detailA Statistically adaptive sampling policy to the Hotelling's T2 Control Chart: Markov Chain Approach
Seif, A.; Faraz, Alireza ULg; Heuchenne, Cédric ULg et al

in Communications in Statistics : Theory & Methods (2014)

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See detailAADOPEASE : un acronyme des compétences des soignants-éducateurs en ETP
Leclercq, Dieudonné ULg

in Education Thérapeutique du Patient [=ETP] = Therapeutic Patient Education [=TPE] (2014), 6(1), 1-10

Introduction: Competencies (functions) endorsed by TPE professional actors can be summarized in 9 (French) words, that can be easily memorized as an acronym:AADOPEASE, referring (in French) to Announcing ... [more ▼]

Introduction: Competencies (functions) endorsed by TPE professional actors can be summarized in 9 (French) words, that can be easily memorized as an acronym:AADOPEASE, referring (in French) to Announcing, Accueil (welcoming), Diagnosis (of educational needs), Objectives, Planning, Education, Apprentissage (Learning), Suivi (Coaching) and Evaluation. Objectives: This acronym is intended to facilitate the analysis of existing therapeutic education tasks and the conception of future ones, including training programs for educational care givers. Description: After conceptual precisions on terms such as competencies, capacities, situations, tasks, activities, resources, each of the AADOPEASE competencies is summarized and commented. Conclusions: In the perspective of offering a convenient bird view of a training program in TPE, the present approach, focused on objectives would offer a summary that should be completed by such a one on training and educating methods and on evaluation methods. [less ▲]

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See detailInfluence du changement climatique sur l'accroissement du hêtre en Wallonie
Latte, Nicolas ULg; Claessens, Hugues ULg

in Forêt Wallonne (2014), (129), 46-47

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See detailEmotional Facial Expression Recognition and Expressivity in Type I and Type II Alcohol Dependent Patients
Dethier, Marie ULg; El Hawa, Maya; Duchateau et al

in Journal of Nonverbal Behavior (2014), 38(1), 89-105

Objective: Alcohol dependent patients (ADs) are known to encounter severe interpersonal problems. Nonverbal communication skills are important for the development of healthy relationships. The present ... [more ▼]

Objective: Alcohol dependent patients (ADs) are known to encounter severe interpersonal problems. Nonverbal communication skills are important for the development of healthy relationships. The present study aimed to explore emotional facial expression (EFE) recognition and posed and spontaneous EFE expressivity in male ADs divided into two groups according to Cloninger’s typology and the impact of their interpersonal relationship quality on the potential nonverbal deficits. Method: Twenty type I ADs, twenty-one type II ADs, and twenty control participants took part in an EFE recognition task and an EFE expressivity task that considered personal emotional events (spontaneous expressivity) and EFE in response to a photo or word cue (posed expressivity). Coding was based on judges’ ratings of participants’ emotional facial expressions. Participants additionally completed a questionnaire on interpersonal relationship quality. Results: No difference between the three groups emerged in the EFE recognition task. Type II ADs showed heightened deficits compared with type I ADs in EFE expressivity: Judges perceived less accurate posed EFE in response to a cue word and less intense and positive spontaneous EFE in type II ADs compared to control participants. In addition, type II ADs reported more relationship difficulties compared to both type I ADs and control participants. These interpersonal relationship difficulties were related to some of the EFE expressivity deficits of AD-IIs. Conclusions: This study underlines the important differences between the interpersonal functioning of AD subtypes. [less ▲]

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See detailVaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.
Gutierrez, Geronimo; Rodriguez, Sabrina M.; De Brogniez, Alix ULg et al

in Viruses (2014), 6(6), 2416-2427

Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly ... [more ▼]

Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy. [less ▲]

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See detailOutcomes of adults with active or progressive hematological malignancies at time of allogeneic stem cell transplantation : a survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Chevallier, P.; Labopin, M.; Milpied, N. et al

in Bone Marrow Transplantation (2014), 49

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective ... [more ▼]

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective study aimed to analyze the outcome of adult patients who received allo-SCT in a chemo-refractory/relapsed status. The series included 840 patients with active or progressive disease at the time of transplant. Median age was 50 years. With a median follow-up of 40 months, 3-year OS, disease-free survival (DFS), and non-relapse mortality rates were 29±2, 23±2, and 30±2%, respectively. At the last follow-up, 252 patients (30%) were still alive (of whom 201 were in CR (24%). In a Cox multivariate analysis, the use of a reduced-intensity conditioning (RIC) before allo-SCT and use of an HLA-identical sibling donor remained independently associated with a better OS (hazard ratio (HR)¼0.82; 95% confidence interval (CI), 0.69–0.98, P¼0.03; and HR¼0.79; 95% CI, 0.66–0.93, P¼0.006, respectively). Also, a diagnosis of myelodysplastic syndrome/myeloproliferative disorder, Hodgkin lymphoma and non-Hodgkin lymphoma compared with acute leukemia had a favorable impact on OS (HR¼0.55; 95% CI, 0.45–0.68, Po0.0001; HR¼0.49; 95% CI, 0.31–0.75, P¼0.001; and HR¼0.47; 95% CI, 0.35–0.63, Po0.0001, respectively). In conclusion, this study suggests that allo-SCT may be of benefit in some subgroups of patients with active or progressive hematological malignancies at the time of allo-SCT. [less ▲]

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See detailLate Quaternary evolution of sediment provenances in the Central
Fagel, Nathalie ULg; Not, Christelle; Gueibe, Jonathan et al

in Quaternary Science Reviews (2014), 92

Mineral assemblage, trace element content and Nd and Pb isotope signatures were analysed on the fine fraction (<20 mm) of sedimentary records from the Northern Mendeleev Ridge in the Central Arctic Ocean ... [more ▼]

Mineral assemblage, trace element content and Nd and Pb isotope signatures were analysed on the fine fraction (<20 mm) of sedimentary records from the Northern Mendeleev Ridge in the Central Arctic Ocean. Our aimwas to identify the detrital particle provenance and to interpret the changes over the past w250 ka in the relative contribution of the different source-areas in relation to paleoenvironmental conditions. The clay mineral assemblage and the Nd and Pb isotope signatures depict systematic changes over the Late Quaternary. The bulk mineralogy exhibits increases in the relative contribution of carbonate minerals vs. silicates in interglacial/deglacial intervals. In glacial intervals, the mineral assemblage of the <20 mm fraction is characterised by an enrichment in kaolinite, counterbalanced by a decrease in illite. The Nd and Pb isotope signatures of <20 mm fraction are interpreted using a three end-member mixing model, involving crustal supplies from North America and Canada, from the Siberian margin and some from volcanic material. A compilation of geochemical signatures of geological terraines surrounding the Arctic Ocean allowed each end-member to be assigned a representative signature, averaging the signal of the eroded terraines. The Suspended Particulate Matter (SPM) of the MacKenzie River represents an average signature of the sedimentary supplies delivered from the North American platform and Canadian margin. The SPM of the Lena River reflects the mean sedimentary signature of the Siberian platform. The Okhotsh-Chukotka province from the Eastern border of Siberia is identified as the most probable volcanic source. Late Quaternary evolution of the estimated relative contribution of the three end-members confirms that the sediment provenances in the Central Arctic Ocean remain close to the current conditions during past interglacials/deglacials MIS1e3, MIS5/TII and MIS7/TIII. In contrast, glacial conditions (MIS4 and MIS6) record minimum supplies from the American margin, associated with increased volcanic contribution, to the Mendeleev Ridge core location suggesting a different sea-ice circulation associated with a low sea-level and reduced shelf area. [less ▲]

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See detailSaint-Ghislain/Sirault : les polissoirs romains découverts en 1998, indices d'une forge spécialisée ?
Thiebaux, Aurélie ULg; Ansieau, Cécile; Henrich, Peter et al

in Chronique de l'Archéologie Wallonne (2014), 21

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See detailThe anorectic effects of alpha-lipoicacid are mediated by central AMPK and are not due to taste aversion in chicken (Gallus gallus)
Wang, Y.; Song, Z.; Everaert, Nadia ULg et al

in Physiology & Behavior (2014), 132

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