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See detailL'âgisme et ses conséquences cliniques en oncogériatrie: état des lieux et pistes d'interventions
Schroyen, Sarah ULg; Adam, Stéphane ULg; Jerusalem, Guy ULg et al

in Revue Médicale de Liège (2014), 69(5-6), 395-401

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See detailRemote sensing of colour, temperature and salinity – new challenges and opportunities
Alvera Azcarate, Aïda ULg; Ruddick, Kevin; Minnett, Peter

in Remote Sensing of Environment (2014), 146

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See detailIntense pulsed light in infantile hemangiomas.
PAQUET, Philippe ULg; Caucanas, Marie; FRANCHIMONT, Claudine ULg et al

in Open Access Journal of Science and Technology (2014), 2

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of ... [more ▼]

For more than 70 years, the watchful-waiting management of infantile strawberry hemangiomas still prevails in a number of clinical settings. This concept appears now outdated since the introduction of well-suited beta-blockers, as well as noncoherent light and laser therapies. The aim of this work was to revisit the effect of intense pulsed light (IPL) therapy on infantile hemangioma. Information was collected from the peer-reviewed literature and illustrated by personal cases. When applied early in the evolution of infantile hemangiomas, IPL treatment stops the growth phase and induces regression with minimal cosmetic adverse effects and psychological damage. Initiating an adequate treatment is important because damage due to hemangiomas can be diminished by a timely and adequate approach. Beta-blockers have revolutionized the therapeutic strategy of infantile hemangiomas. The flash light therapy (IPL) represents an alternative therapy for some patients. [less ▲]

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See detailGeneric results in classes of ultradifferentiable functions
Esser, Céline ULg

in Journal of Mathematical Analysis & Applications (2014), 413(1), 378391

Let E be a Denjoy Carleman class of ultradifferentiable functions of Beurling type on the real line that strictly contains another class F of Roumieu type. We show that the set S of functions in E that ... [more ▼]

Let E be a Denjoy Carleman class of ultradifferentiable functions of Beurling type on the real line that strictly contains another class F of Roumieu type. We show that the set S of functions in E that are nowhere in the class F is large in the topological sense (it is residual), in the measure theoretic sense (it is prevalent), and that SU{0} contains an infinite dimensional linear subspace (it is lineable). Consequences for the Gevrey classes are given. Similar results are also obtained for classes of ultradifferentiable functions defined imposing conditions on the Fourier Laplace transform of the function. [less ▲]

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See detailVisual neglect: Is there a relationship between impaired spatial working memory and re-cancellation?
Wansard, Murielle ULg; Meulemans, Thierry ULg; Gillet, Sophie ULg et al

in Experimental Brain Research (2014)

In visual search tasks, neglect patients tend to explore and repeatedly re-cancel stimuli on the ipsilesional side, as if they did not realize that they had previously examined the rightward locations ... [more ▼]

In visual search tasks, neglect patients tend to explore and repeatedly re-cancel stimuli on the ipsilesional side, as if they did not realize that they had previously examined the rightward locations favoured by their lateral bias. The aim of this study was to explore the hypothesis that a spatial working memory deficit explains these ipsilesional re-cancellation errors in neglect patients. For the first time, we evaluated spatial working memory and re-cancellation through separate and independent tasks in a group of patients with right hemisphere damage and a diagnosis of left neglect. Results showed impaired spatial working memory in neglect patients. Compared to the control group, neglect patients cancelled fewer targets and made more re-cancellations both on the left side and on the right side. The spatial working memory deficit appears to be related to re-cancellations, but only for some neglect patients. Alternative interpretations of re-exploration of space are discussed. [less ▲]

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See detailEffect of Body Weight Loss on Cardiopulmonary Function assessed by 6-Minute Walk Test and Arterial Blood Gas Analysis in Obese Dogs
Manens; Ricci, R; Damoiseaux, C et al

in Journal of Veterinary Internal Medicine (2014), 28(2), 371-378

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See detailCoherent Backscattering in Fock Space: A Signature of Quantum Many-Body Interference in Interacting Bosonic Systems
Engl, Thomas; Dujardin, Julien ULg; Argüelles, Arturo et al

in Physical Review Letters (2014), 112

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with ... [more ▼]

We predict a generic signature of quantum interference in many-body bosonic systems resulting in a coherent enhancement of the average return probability in Fock space. This enhancement is robust with respect to variations of external parameters even though it represents a dynamical manifestation of the delicate superposition principle in Fock space. It is a genuine quantum many-body effect that lies beyond the reach of any mean-field approach. Using a semiclassical approach based on interfering paths in Fock space, we calculate the magnitude of the backscattering peak and its dependence on gauge fields that break time-reversal invariance. We confirm our predictions by comparing them to exact quantum evolution probabilities in Bose-Hubbard models, and discuss their relevance in the context of many-body thermalization. [less ▲]

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See detailCaractéristiques de reproduction de la femelle trypanotolérante de race N’Dama.
Okouyi, Marcel; Kamga Waladjo, Alain; Diarra, S et al

in Revue Africaine de Santé et de Productions Animales [=RASPA] (2014), 12(1), 3-7

Knowledge about the reproductive N’Dama remain old and very general, observations have been most often performed on a limited number of animals and in different contexts. This inventory confirms the need ... [more ▼]

Knowledge about the reproductive N’Dama remain old and very general, observations have been most often performed on a limited number of animals and in different contexts. This inventory confirms the need to continue and intensify so as federated possible studies to further clarify the characteristcs and reproductive performance of this important development potential of cattle that represents the N’Dama to Africa. [less ▲]

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See detailNeuroimaging, cognition, light and circadian rhythms
Gaggioni, Giulia ULg; Maquet, Pierre ULg; Schmidt, Christina et al

in Frontiers in Systems Neuroscience [=FNSYS] (2014)

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See detailSeagrass amphipod assemblages in a Mediterranean marine protected area: a multiscale approach
Sturaro, Nicolas ULg; Lepoint, Gilles ULg; Pérez-Perera, Amanda et al

in Marine Ecology. Progress Series (2014), 506

Marine protected areas (MPAs) are a key tool for conservation purposes, but few studies have assessed the responses of small macrozoobenthic assemblages to different protection levels in the Mediterranean ... [more ▼]

Marine protected areas (MPAs) are a key tool for conservation purposes, but few studies have assessed the responses of small macrozoobenthic assemblages to different protection levels in the Mediterranean Sea. In this study, we used a hierarchical sampling design spanning three orders of magnitude (1-10-100 metres) to investigate whether a marine protected area exerts an effect on amphipod assemblages associated with Posidonia oceanica meadows. This study reports spatial and temporal variability patterns of amphipod assemblages in four different protection levels and discusses potential confounding effects, such as habitat features. The structure of amphipod assemblages based on density data was patchy at all spatial scales investigated, but differed markedly among protection levels. Among outstanding points, multiscale analyses showed that lower densities and/or biomasses of several taxa occurred within fully protected and external areas in comparison with partially protected areas (PPAs). Furthermore, Posidonia oceanica meadow features (shoot density, leaf and epiphyte biomasses, coefficient A and litter biomass) accounted for only a low proportion of the total variability. We can consequently infer that the observed patchiness is likely to occur for multiple and interconnected reasons, ranging from the ecological and behavioural traits of amphipod species to protection-dependent processes (e.g. fish predation). Long term multiscale spatial and temporal monitoring, as well as experimental manipulations, are clearly needed to fully understand the effects of protection on macrozoobenthic assemblages. [less ▲]

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See detailReproductive ecology of Coula edulis Baill., source of a valuable non-timber forest product
Moupela, Christian ULg; Doucet, Jean-Louis ULg; Daïnou, Kasso ULg et al

in Tropical Ecology (2014), 55(3), 327-338

The reproductive ecology of Coula edulis (Olacaceae), source of a highly valuable non-timber product for African populations, has been investigated on a large tree sample size in a Gabonese forest for a 3 ... [more ▼]

The reproductive ecology of Coula edulis (Olacaceae), source of a highly valuable non-timber product for African populations, has been investigated on a large tree sample size in a Gabonese forest for a 3-year period, in order to propose options for its domestication. Reproduction is annual and the minimum tree diameter for flowering was 10.6 cm while the diameter for regular fructification was 23 cm. The annual diameter increment (ADI; mean = 0.22 cm year-1) was affected by crown exposure, but not by initial tree diameter or fruit production. Tree diameter influenced fruiting frequency and fruit production. There was a strong correlation between fruit production of 2011 and 2012 (Pearson's r = 0.85; P < 0.001), suggesting a high heritability of that trait. Phenotypical selection should be performed prior to any propagation activity. Moreover, as most of C. edulis fruits were sterile (64 %), we propose that sylvicultural strategies should be based on vegetative propagation. [less ▲]

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See detailPatterns in national policies for support of low achievers in reading across Europe
Motiejunaite, Akvile; Noorani, Sogol; Monseur, Christian ULg

in British Educational Research Journal (2014)

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See detailCouvin/Couvin : Trou de l'Abîme
Miller, Rebecca ULg; Cattelain, Pierre; Otte, Marcel ULg et al

in Chronique de l'Archéologie Wallonne (2014), 21

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See detailLa recette commentée sur la toile: un genre renouvelé?
Meunier, Deborah ULg; Rosier, Laurence

in Arena Romanistica (2014), 14

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of ... [more ▼]

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of the recipe’s very form, which was initially a case of linear transmission in a chronological sense, towards a dialogal and polyphonic form in which the original posted recipe becomes recipe only when it is enlivened with commentaries which complete and perform it. Our contribution aims to show this discursive co-construction. From the point of view of genres, we will also see that those genres which are known as monologal or fixed can evolve towards dialogal and dialogical forms. [less ▲]

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See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging. Part I.
Edvardsen, Thor; Plein, Sven; Saraste, Antti et al

in European heart journal cardiovascular Imaging (2014), 15(7), 730-735

The new multimodality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here, we summarize the most important studies from the journal's second year in ... [more ▼]

The new multimodality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here, we summarize the most important studies from the journal's second year in two articles. Part I of the review will focus on studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging, and Part II will focus on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

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See detailThe Dimethylsulfide Cycle in the Eutrophied Southern North Sea: A Model Study Integrating Phytoplankton and Bacterial Processes
Gypens, N; Borges, Alberto ULg; Speeckaert, Gaëlle ULg et al

in Plos One (2014), 9(1)(e85862 DOI: 10.1371/journal.pone.0085862),

We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical ... [more ▼]

We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical processes (including DMS air-sea exchange). This module was integrated in the MIRO ecological model and applied in a 0D frame in the Southern North Sea (SNS). The DMS(P) module is built on parameterizations derived from available knowledge on DMS(P) sources, transformations and sinks, and provides an explicit representation of bacterial activity in contrast to most of existing models that only include phytoplankton process (and abiotic transformations). The model is tested in a highly productive coastal ecosystem (the Belgian coastal zone, BCZ) dominated by diatoms and the Haptophyceae Phaeocystis, respectively low and high DMSP producers. On an annual basis, the particulate DMSP (DMSPp) production simulated in 1989 is mainly related to Phaeocystis colonies (78%) rather than diatoms (13%) and nanoflagellates (9%). Accordingly, sensitivity analysis shows that the model responds more to changes in the sulfur:carbon (S:C) quota and lyase yield of Phaeocystis. DMS originates equally from phytoplankton and bacterial DMSP-lyase activity and only 3% of the DMS is emitted to the atmosphere. Model analysis demonstrates the sensitivity of DMS emission towards the atmosphere to the description and parameterization of biological processes emphasizing the need of adequately representing in models both phytoplankton and bacterial processes affecting DMS(P) dynamics. This is particularly important in eutrophied coastal environments such as the SNS dominated by high non-diatom blooms and where empirical models developed from data-sets biased towards open ocean conditions do not satisfactorily predict the timing and amplitude of the DMS seasonal cycle. In order to predict future feedbacks of DMS emissions on climate, it is needed to account for hotspots of DMS emissions from coastal environments that, if eutrophied, are dominated not only by diatoms. [less ▲]

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See detailLe consociationalisme à l'épreuve du fédéralisme. Les paradoxes du système de décision politique en Belgique
Piron, Damien ULg; Verjans, Pierre ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), 59(1), 173-189

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See detailElaboration of Thin Foils in Copper and Zinc by Self-Induced Ion Plating
Giraud, Eliane; Pace, Sergio ULg; Lecomte-Beckers, Jacqueline ULg

in Materials Science (2014), 20(2), 160-164

The aim of this work was to determine the ability to produce thin metallic foils by self-induced ion plating. Foils of pure copper and pure zinc with a thickness of 35 μm have been successfully produced ... [more ▼]

The aim of this work was to determine the ability to produce thin metallic foils by self-induced ion plating. Foils of pure copper and pure zinc with a thickness of 35 μm have been successfully produced and their characteristics have been compared to foils obtained by conventional techniques (i. e. electroplating and rolling). Results show the following: (i) more or less compact microstructures can be obtained by self-induced ion plating depending on gas pressure and substrate temperature; (ii) microstructures obtained by self-induced ion plating are quite different from those obtained by electroplating and rolling; (iii) Young’s modulus depends on foils roughness; (iv) hardness depends on grain size by exhibiting a Hall-Petch behavior in the case of copper foils and an “inverse” Hall-Petch behavior in the case of zinc foils. [less ▲]

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See detailAntiresorptive Drugs Beyond Bisphosphonates and Selective Oestrogen Receptor Modulators for the Management of Postmenopausal Osteoporosis.
Reginster, Jean-Yves ULg; Neuprez, A.; Beaudart, Charlotte ULg et al

in Drugs & aging (2014), 31

Osteoporotic fractures are a major cause of morbidity in the elderly population. Since postmenopausal osteoporosis is related to an increase in osteoclastic activity at the time of menopause, inhibitors ... [more ▼]

Osteoporotic fractures are a major cause of morbidity in the elderly population. Since postmenopausal osteoporosis is related to an increase in osteoclastic activity at the time of menopause, inhibitors of bone resorption have genuinely been considered an adequate strategy for prevention and treatment of osteoporosis. Bisphosphonates and selective oestrogen receptor modulators are widely prescribed to treat osteoporosis. However, other antiresorptive drugs have been developed for the management of osteoporosis, with the objective of providing a substantial reduction in osteoporotic fractures at all skeletal sites, combined with an acceptable long-term skeletal and systemic safety profile. Denosumab, a human monoclonal antibody to receptor activator for nuclear factor kappa B ligand, has shown efficacy against vertebral, nonvertebral and hip fractures. Its administration every 6 months as a subcutaneous formulation might significantly influence compliance and persistence to therapy. Additional results regarding long-term skeletal safety (i.e. osteonecrosis of the jaw and atypical diaphyseal femoral fracture) are needed. Odanacatib, a selective cathepsin K inhibitor, is a promising new approach to the inhibition of osteoclastic resorption, with the potential to uncouple bone formation from bone resorption. Results regarding its anti-fracture efficacy are expected in the coming months. [less ▲]

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See detailDe Jacques Antoine aux éditions des Eperonniers : l'édition littéraire en Belgique au passé et au présent (première partie)
Durand, Pascal ULg; Habrand, Tanguy ULg

in Textyles : Revue des Lettres Belges de Langue Française (2014), 45

Première partie (POSITION ÉDITORIALE ET PATRIMONIALISATION LITTÉRAIRE : JACQUES ANTOINE) d'un article en deux volets dont le second porte sur la transition des éditions Jacques Antoine aux éditions des ... [more ▼]

Première partie (POSITION ÉDITORIALE ET PATRIMONIALISATION LITTÉRAIRE : JACQUES ANTOINE) d'un article en deux volets dont le second porte sur la transition des éditions Jacques Antoine aux éditions des Eperonniers et sur l'histoire et la politique éditoriale de cette dernière maison (CRÉATION CONTEMPORAINE ET POLITIQUES DU LIVRE : LYSIANE D’HAEYERE AUX ÉPERONNIERS). [less ▲]

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See detailLe rôle de l’entourage au sein de l’hôpital africain : une thématique négligée ?
Schnitzler, Marie ULg

in Sciences Sociales et Santé (2014), 32(1), 39-64

En mobilisant le cadre théorique interactionniste pensé par Strauss (1992), cet article décrit les différentes tâches effectuées par l’entourage du malade dans un hôpital béninois afin de montrer comment ... [more ▼]

En mobilisant le cadre théorique interactionniste pensé par Strauss (1992), cet article décrit les différentes tâches effectuées par l’entourage du malade dans un hôpital béninois afin de montrer comment ce travail réalisé gratuitement par des travailleurs profanes favorise le fonctionnement au jour le jour de la structure. Les concepts d’« intermédiation » et de « dépendance » permettent de saisir les contraintes familiales exercées sur le patient en plus du contrôle médical. En conclusion, cet article prône le développement d’études sur les garde-malades pour renouveler les recherches sur la relation thérapeutique et sur l’organisation hospitalière en Afrique de l’Ouest. [less ▲]

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See detailTeaching conservation-restoration in an art school: sharing expériences
Verbeeck, Muriel ULg; Breuil, Marie-Hélène

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2014)

Teaching conservation-restoration in an art school can be considered a blessing as well as a challenge: What is the position of a conservator-restorator in this environment? What are the relationships ... [more ▼]

Teaching conservation-restoration in an art school can be considered a blessing as well as a challenge: What is the position of a conservator-restorator in this environment? What are the relationships between art conservation and creation, creation and technique? What legitimises research in conservation-restoration, scientific or applied, in this context? This paper, based on our teaching experiences in France and in Belgium reveals a field of expertise and the necessity of understanding the processes of art creation holistically. [less ▲]

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See detailHearing capacities and otolith size in two ophidiiform species (Ophidion rochei and Carapus acus)
Kever, Loïc ULg; Colleye, Orphal ULg; Herrel, Anthony et al

in Journal of Experimental Biology (2014), 217

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See detailTwo novel mutations of the CLDN16 gene cause familial hypomagnesaemia with hypercalciuria and nephrocalcinosis
Hanssen, Oriane ULg; CASTERMANS, Emilie ULg; BOVY, Christophe ULg et al

in Clinical Kidney Journal (2014), 7

Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis is an autosomal-recessive disease caused by mutations in the CLDN16 or CLDN19 genes, which encode tight junction-associated proteins ... [more ▼]

Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis is an autosomal-recessive disease caused by mutations in the CLDN16 or CLDN19 genes, which encode tight junction-associated proteins, claudin-16 and -19. The resultant tubulopathy leads to urinary loss of Mg2+ and Ca2+, with subsequent nephrocalcinosis and end-stage renal disease (ESRD). An 18-year-old boy presented with chronic kidney disease and proteinuria, as well as hypomagnesaemia, hypercalciuria and nephrocalcinosis. A kidney biopsy revealed tubular atrophy, interstitial fibrosis and segmental sclerosis of some glomeruli. Two novel mutations in the CLDN16 gene were identified: c.340C>T (nonsense) and c.427+5G>A (splice site). The patient reached ESRD at 23 and benefited from kidney transplantation. [less ▲]

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See detailDevelopmental defects in zebrafish for classification of EGF pathway inhibitors.
Pruvot, Benoist ULg; Curé, Yoann ULg; Djiotsa, Joachim et al

in Toxicology and Applied Pharmacology (2014), 274

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See detailUn monde entre accélération et incertitudes
Santander, Sébastian ULg

in Interventions Economiques = Papers in Political Economy (2014)

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See detailEvaluation of Adherence to a Convulsion management Protocol for Children in Rwanda
kaputu-kalal-malu, Célestin; D'Amour Birindabagabo, Jean; Walker, Timothy David et al

in Journal of Tropical Pediatrics (2014), 60(2), 124-128

Inappropriate seizure management may result in high morbidity and mortality. We assessed the adherence of health professionals in southern Rwanda to a national protocol for pharmacological management of ... [more ▼]

Inappropriate seizure management may result in high morbidity and mortality. We assessed the adherence of health professionals in southern Rwanda to a national protocol for pharmacological management of seizures in children. A questionnaire featuring a 5-year-old child with generalized prolonged seizures was administered. The questions focused on the choice of initial treatment and the sequence of management following failure of the initial treatment choice. Benzodiazepine was chosen as initial therapy by 93.7% of physicians and 90.9% of nurses. Only 49.2% of physicians and 41% of nurses would repeat the initial treatment in case of failure of the first dose and 47% of doctors would wait 30 min to intervene. In case of refractory status epilepticus, 34% of physicians would give three doses of benzodiazepine, whereas 19% did not know what to do. These results suggest poor adherence to national protocol. [less ▲]

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See detailSPECT/CT workflow and imaging protocols.
Beckers, Catherine; Hustinx, Roland ULg

in European journal of nuclear medicine and molecular imaging (2014), 41

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow ... [more ▼]

PURPOSE: Introducing a hybrid imaging method such as single photon emission computed tomography (SPECT)/CT greatly alters the routine in the nuclear medicine department. It requires designing new workflow processes and the revision of original scheduling process and imaging protocols. In addition, the imaging protocol should be adapted for each individual patient, so that performing CT is fully justified and the CT procedure is fully tailored to address the clinical issue. Such refinements often occur before the procedure is started but may be required at some intermediate stage of the procedure. Furthermore, SPECT/CT leads in many instances to a new partnership with the radiology department. This article presents practical advice and highlights the key clinical elements which need to be considered to help understand the workflow process of SPECT/CT and optimise imaging protocols. METHODS: The workflow process using SPECT/CT is complex in particular because of its bimodal character, the large spectrum of stakeholders, the multiplicity of their activities at various time points and the need for real-time decision-making. RESULTS: With help from analytical tools developed for quality assessment, the workflow process using SPECT/CT may be separated into related, but independent steps, each with its specific human and material resources to use as inputs or outputs. This helps identify factors that could contribute to failure in routine clinical practice. At each step of the process, practical aspects to optimise imaging procedure and protocols are developed. A decision-making algorithm for justifying each CT indication as well as the appropriateness of each CT protocol is the cornerstone of routine clinical practice using SPECT/CT. CONCLUSION: In conclusion, implementing hybrid SPECT/CT imaging requires new ways of working. It is highly rewarding from a clinical perspective, but it also proves to be a daily challenge in terms of management. [less ▲]

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See detailEchocardiographic reference ranges for normal cardiac chamber size: results from the NORRE study.
Kou, Seisyou; Caballero, Luis; Dulgheru, Raluca et al

in European heart journal cardiovascular Imaging (2014), 15(6), 680-690

AIMS: Availability of normative reference values for cardiac chamber quantitation is a prerequisite for accurate clinical application of echocardiography. In this study, we report normal reference ranges ... [more ▼]

AIMS: Availability of normative reference values for cardiac chamber quantitation is a prerequisite for accurate clinical application of echocardiography. In this study, we report normal reference ranges for cardiac chambers size obtained in a large group of healthy volunteers accounting for gender and age. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following chamber quantitation protocols approved by the European Association of Cardiovascular Imaging. METHODS: A total of 734 (mean age: 45.8 +/- 13.3 years) healthy volunteers (320 men and 414 women) were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was performed on all subjects following pre-defined protocols. There were no gender differences in age or cholesterol levels. Compared with men, women had significantly smaller body surface areas, and lower blood pressure. Quality of echocardiographic data sets was good to excellent in the majority of patients. Upper and lower reference limits were higher in men than in women. The reference values varied with age. These age-related changes persisted for most parameters after normalization for the body surface area. CONCLUSION: The NORRE study provides useful two-dimensional echocardiographic reference ranges for cardiac chamber quantification. These data highlight the need for body size normalization that should be performed together with age-and gender-specific assessment for the most echocardiographic parameters. [less ▲]

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See detailAUTOMATISATION DE LA DÉTECTION DES CRATÈRES LUNAIRES SUR DES IMAGES ET MNT PLANÉTAIRES
Renson, Pierre; Poncelet, Nadia; Vandeloise, Yannick et al

in Bulletin de la Société Géographique de Liège (2014), 61

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images ... [more ▼]

This research is part of the preparation of a lunar mission. Its objective is to implement, test and validate an automated method that detects craters on the lunar surface from planetary products (images and DTM). In this context, the automation of the process is essential because the craters represent a landing risk and landmarks for visual navigation. It is also the key challenge because it is difficult to develop high level automatic processing comparable to the thinking carried out in a traditional visual interpretation. Our method automatically establishes a semantic diagnosis based on the combination of crater descriptors computed on the planetary products used. Finally, this application is part of a decision support tool and an assessment system of landing and mission survival risks. It also aims to feed a landmarks database for automatic visual navigation of a lunar landing spacecraft. [less ▲]

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See detailPhase diagram of BiFeO3/LaFeO3 superlattices studied by x-ray diffraction experiments and first-principles calculations
Rispens, Gijsbert; Ziegler, Benedikt; Paruch, Patrycja et al

in Physical Review. B, Condensed Matter and Materials Physics (2014), 90

Combining structural and functional measurements, we have mapped the phase diagram of BiFeO3/LaFeO3 superlattices grown by off-axis sputtering on (110)o DyScO3 substrates. The phase diagram displays three ... [more ▼]

Combining structural and functional measurements, we have mapped the phase diagram of BiFeO3/LaFeO3 superlattices grown by off-axis sputtering on (110)o DyScO3 substrates. The phase diagram displays three distinct regions as a function of BiFeO3 fraction, with a BiFeO3-like ferroelectric phase and a LaFeO3-like paraelectric phase at its extremities, and a complex intermediate region, as supported by first-principles calculations. This intermediate region shows unusual, mixed functional behavior, most likely due to competing phases driven by substitution with a same-size central ion and the specific boundary conditions imposed by the superlattice structure. In the BiFeO3 rich superlattices, scaling of the ferroelectric-to-paraelectric transition temperature with the BiFeO3 thickness could provide an alternate route for studying ferroelectric size effects in BiFeO3. [less ▲]

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See detailCalcium, phosphorus, magnesium and vitamin D requirements of the preterm infants
Mimouni, F; Mandel, D; Lubetzky, R et al

in World Review of Nutrition and Dietetics (2014), 110

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See detailLe myélome multiple asymptomatique : le paysage thérapeutique change
CAERS, Jo ULg; BEGUIN, Yves ULg

in Oncol. Hematol. (2014), 8

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade ... [more ▼]

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade précurseur du myélome multiple. En moyenne, les patients présentant un myélome asymptomatique ont un risque annuel de progression en myélome déclaré de 10%. Différents facteul"s ont été combinés dans des modélisations pronostiques: le rapport des chaînes légères, les anomalies radiologiques, la présence d'une gammapathie évolutive et l'infiltration médullaire > 60% ont récemment été identifiés comme facteurs prédictifs d'une progression précoce pour lesquels certains auteurs évoquent la mise en roùte d'un traitement anti-myélome. Cette stratégie thérapeutique précoce a démontré son efficacité dans une étude randomisée qui comparait un traitement par lénalidornide et dexaméthasone avec une approche attentiste chez des patients à risque. [less ▲]

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See detailGenetic and kinetic characterization of the novel AmpC beta-lactamases DHA-6 and DHA-7.
Perez-Llarena, Francisco Jose; Zamorano, Laura; Kerff, Frédéric ULg et al

in Antimicrobial agents and chemotherapy (2014)

During a Spanish surveillance study, two natural variants of DHA beta-lactamases, DHA-6 and DHA-7 were found, with the replacements Ala226Thr and Phe322Ser respect to DHA-1, respectively. The enzymes were ... [more ▼]

During a Spanish surveillance study, two natural variants of DHA beta-lactamases, DHA-6 and DHA-7 were found, with the replacements Ala226Thr and Phe322Ser respect to DHA-1, respectively. The enzymes were isolated from Escherichia coli and Enterobacter cloacae clinical isolates, respectively. The aim of the study was the genetic, microbiological and biochemical characterization of the DHA-6 and DHA-7 beta-lactamases. The blaDHA-6 andblaDHA-7 genes were located in I1 and HI2 incompatibility group plasmids of 87.3 and 310.4 kb, respectively. The gene context of both blaDHA-6 andblaDHA-7 was similar to that already described for blaDHA-1 gene and included the qnrB4 and aadA genes. The MICs for cephalothin, aztreonam, cefotaxime and ceftazidime were 8 to 30 fold lower for the DHA-6 than for DHA-1 and DHA-7 expressed in the same isogenic E.coli TG1 strain. Interestingly the MIC for cefoxitin was higher in DHA-6 expressing transformant compared to DHA-1 and DHA-7. Biochemical studies with pure beta-lactamases revealed a slightly lower catalytic efficiency of DHA-6 against cephalothin, ceftazidime and cefotaxime compared to DHA-1 and DHA-7. To understand this behavior, stability experiments were carried out and showed that the DHA-6 protein displayed a significantly higher stability than DHA-1 and DHA-7 enzymes. The proximity of Thr226 to the N-terminal in the tertiary protein structure in DHA-6 may promote this stabilization and consequently could induce a slight reduction of the dynamic of this enzyme primarily affecting the hydrolysis of some of the bulkiest antibiotics. [less ▲]

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See detailAn online interactive tool to assess energy consumption in residential buildings and for daily mobility
Marique, Anne-Françoise ULg; de Meester, Tatiana; De Herde, André et al

in Energy and Buildings (2014), 78C

Improving energy efficiency in the building and transportation sectors is a viable approach to mitigate the effects of climate change and has become an important policy target. As a result, in addition to ... [more ▼]

Improving energy efficiency in the building and transportation sectors is a viable approach to mitigate the effects of climate change and has become an important policy target. As a result, in addition to scientific research and public policies addressing energy efficiency, raising public awareness of the impact of the behaviour of citizens to energy efficiency is crucial and could quickly lead to significant reductions in the total energy consumption of a territory. In this context, this paper presents a new online interactive tool that enables not only citizens but also local authorities and private developers to (1) assess the sources of energy consumption related to housing and to daily mobility at both the individual and neighbourhood scales, (2) compare these sources and (3) determine relevant and personalised suggestions to reduce energy consumption. Numerous methods and tools, including a typological classification of buildings, thermal dynamic simulations, life-cycle assessments and statistical treatments of national censuses, were used to produce the two large databases used in this interactive tool. This report represents the primary results of a three-year long scientific research project dedicated to the study of energy efficiency in buildings and for daily mobility that is accessible to a large non-specialised audience. [less ▲]

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See detailThe self-report Version of the LSAS-CA: Psychometric Properties of the French Version in a non-clinical adolescent sample
Schmits, Emilie ULg; Heeren, Alexandre; Quertemont, Etienne ULg

in Psychologica Belgica (2014), 54(2), 181-198

The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The ... [more ▼]

The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The psychometric properties of the self-report version of the LSAS-CA (LSAS-CA-SR) have been investigated in a Spanish population. However, no study to date has adapted and validated this scale in French. The purpose of this study was to develop a French version of the LSAS-CA-SR and to assess its score reliability and structural validity in a French-speaking community sample. The sample was made up of 1,343 teenagers from secondary schools, aged between 14 and 18 years. Confirmatory factor analyses established the structural validity of the French version of the LSAS-CA-SR and good psychometric properties, including reliable internal consistency, were observed. [less ▲]

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See detailOsteonecrosis of the jaw in a male osteoporotic patient treated with denosumab
NEUPREZ, Audrey ULg; Coste, S; Rompen, Eric ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the ... [more ▼]

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk. [less ▲]

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See detailLarge-Scale Proteomics of the Cassava Storage Root and Identification of a Target Gene to Reduce Postharvest Deterioration.
Vanderschuren, Hervé ULg; Nyaboga, Evans; Poon, Jacquelyne S. et al

in The Plant cell (2014), 26(5), 1913-1924

Cassava (Manihot esculenta) is the most important root crop in the tropics, but rapid postharvest physiological deterioration (PPD) of the root is a major constraint to commercial cassava production. We ... [more ▼]

Cassava (Manihot esculenta) is the most important root crop in the tropics, but rapid postharvest physiological deterioration (PPD) of the root is a major constraint to commercial cassava production. We established a reliable method for image-based PPD symptom quantification and used label-free quantitative proteomics to generate an extensive cassava root and PPD proteome. Over 2600 unique proteins were identified in the cassava root, and nearly 300 proteins showed significant abundance regulation during PPD. We identified protein abundance modulation in pathways associated with oxidative stress, phenylpropanoid biosynthesis (including scopoletin), the glutathione cycle, fatty acid alpha-oxidation, folate transformation, and the sulfate reduction II pathway. Increasing protein abundances and enzymatic activities of glutathione-associated enzymes, including glutathione reductases, glutaredoxins, and glutathione S-transferases, indicated a key role for ascorbate/glutathione cycles. Based on combined proteomics data, enzymatic activities, and lipid peroxidation assays, we identified glutathione peroxidase as a candidate for reducing PPD. Transgenic cassava overexpressing a cytosolic glutathione peroxidase in storage roots showed delayed PPD and reduced lipid peroxidation as well as decreased H2O2 accumulation. Quantitative proteomics data from ethene and phenylpropanoid pathways indicate additional gene candidates to further delay PPD. Cassava root proteomics data are available at www.pep2pro.ethz.ch for easy access and comparison with other proteomics data. [less ▲]

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See detailLateral Magnetic Near-Field Imaging of Plasmonic Nanoantennas With Increasing Complexity
Denkova, D.; Verellen, N.; Silhanek, Alejandro ULg et al

in Small : Nano Micro (2014)

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field ... [more ▼]

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field interactions between their building blocks. While the electric field distributions and, respectively, the electric interactions of different nanostructures can be routinely measured, for example, by scattering near-field microscopy, only recently experimental methods for imaging the magnetic field distributions became available. In this paper, we provide direct experimental maps of the lateral magnetic near-field distributions of variously shaped plasmonic nanoantennas by using hollow-pyramid aperture scanning near-field optical microscopy (SNOM). We study both simple plasmonic nanoresonators, such as bars, disks, rings and more complex antennas. For the studied structures, the magnetic near-field distributions of the complex resonators have been found to be a superposition of the magnetic near-fields of the individual constituting elements. These experimental results, explained and validated by numerical simulations, open new possibilities for engineering and characterization of complex plasmonic antennas with increased functionality. [less ▲]

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See detailLinear electro-optic effect in multiferroic BiFeO3 thin films
Sando, D.; Hermet, Patrick ULg; Allibe, J. et al

in Physical Review B (2014), 89

Multiferroics are materials with coexisting magnetic and ferroelectric orders, which show potential for electrically controlled spintronic devices. A common application of ferroelectrics is in electro ... [more ▼]

Multiferroics are materials with coexisting magnetic and ferroelectric orders, which show potential for electrically controlled spintronic devices. A common application of ferroelectrics is in electro-optical modulators exploiting their electric-field-dependent optical indices. The coupling of optical and magnetic degrees of freedom is attractive for designing multifunctional devices, but to date the electro-optical response of multiferroics has hardly been explored. Here we report a joint experimental and theoretical study of this effect in multiferroic BiFeO3 thin films. We confirm the large birefringence present in single crystals and determine the electro-optic coefficients r13 and r33. We present approaches to increase the obtained coefficients, for instance, by using tetragonal-like BiFeO3, and expand the potential of multiferroics to optical applications. [less ▲]

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See detailHigher Symmetries of the Laplacian via Quantization
Michel, Jean-Philippe ULg

in Annales de l'Institut Fourier (2014), 64

We develop a new approach, based on quantization methods, to study higher symmetries of invariant di erential operators. We focus here on conformally invariant powers of the Laplacian over a conformally ... [more ▼]

We develop a new approach, based on quantization methods, to study higher symmetries of invariant di erential operators. We focus here on conformally invariant powers of the Laplacian over a conformally at manifold and recover results of Eastwood, Leistner, Gover and ilhan. In particular, conformally equivariant quantization establishes a correspondence between the algebra of Hamiltonian symmetries of the null geodesic ow and the algebra of higher symmetries of the conformal Laplacian. Combined with a symplectic reduction, this leads to a quantization of the minimal nilpotent coadjoint orbit of the conformal group. The star-deformation of its algebra of regular functions is isomorphic to the algebra of higher symmetries of the conformal Laplacian. Both identify with the quotient of the universal envelopping algebra by the Joseph ideal. [less ▲]

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See detailLes effets du vieillissement normal et pathologique sur la cognition
Collette, Fabienne ULg; Salmon, Eric ULg

in Revue Médicale de Liège (2014), 69(5-6), 265-269

Des troubles cognitifs touchant principalement le fonctionnement exécutif et mnésique sont observés lors du vieillissement normal et de la maladie d’Alzheimer, et sont associés à des changements au niveau ... [more ▼]

Des troubles cognitifs touchant principalement le fonctionnement exécutif et mnésique sont observés lors du vieillissement normal et de la maladie d’Alzheimer, et sont associés à des changements au niveau de l’activité cérébrale. Il apparait toutefois que différents facteurs sont susceptibles de retarder la survenue des troubles cognitifs, tels que la stimulation mentale ou la pratique d’une activité physique. De même, les prises en charge cognitives permettent d’améliorer le fonctionnement au quotidien des patients présentant une maladie d’Alzheimer (MA). Identifier les facteurs et techniques qui contribuent à maintenir une vitalité cognitive et/ou à contrer les effets de la MA permettront d’optimiser la qualité de vie des seniors. [less ▲]

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See detailMonte-Cristo chimiste et physicien des communications : du télégraphe optique au télégraphe électrique
Durand, Pascal ULg

in Cahiers Alexandre Dumas (2014), 41

La scène du télégraphe optique, dans Le Comte de Monte-Cristo, aide à mettre en lumière la modernité du roman. Cette modernité tient pour une part à une ligne de continuité établie entre chronique ... [more ▼]

La scène du télégraphe optique, dans Le Comte de Monte-Cristo, aide à mettre en lumière la modernité du roman. Cette modernité tient pour une part à une ligne de continuité établie entre chronique judiciaire et fable romanesque, sur fond de réseau télégraphique. Elle tient plus encore au fait que cet épisode du télégraphe rend singulièrement visible l’allégorie de la communication que le roman développe à différents niveaux de sa construction narrative, allant de son incipit très sémiologique à la « voile blanche » qui signalera sur fond d’azur méditerranéen, quatorze cents pages plus loin, le départ d’un Monte-Cristo ayant recouvré son identité perdue, en passant par les deux figures successivement incarnées par son héros, dépeint en victime sacrificielle puis en expert d’une communication dont il saura jouer de tous les ressorts — rapidité de déplacement, contrôle de l’information, maîtrise des formes spéculatives et fiduciaires de l’économie, dévoiement des formes anthropologiques de l’échange social, etc. — pour l’emporter finalement sur les trois pouvoirs coalisés de la Politique (Morcerf), de la Justice (Villefort) et de la Banque (Danglars) ; tout cela orchestré par une triple métaphore du sang, de l’argent et de l’information, dont la signification réversible ne peut être séparée d’une doctrine saint-simonienne que Dumas à la fois relaie et révoque. De même que le couloir de communication établi au château d’If entre la cellule de Dantès et celle de Faria, la scène du télégraphe fait ainsi office de point de cristallisation d’une symbolique diffuse. Cette scène si cardinale, il s'agit ici de montrer qu’elle est non seulement grosse encore de tout un savoir à dimension technique autant qu’anthropologique, mais également porteuse, vers d’autres zones du roman, d’une assez étonnante préfiguration du télégraphe électrique, en cheville avec une modernité technique dont Dumas faufile les signes de façon plus ou moins cryptée dans la trame de son roman. [less ▲]

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See detailEffect of gamma-hydroxybutyrate on keratinocytes proliferation: a preliminary prospective controlled study in severe burn patients.
ROUSSEAU, Anne-Françoise ULg; BARGUES, Laurent; LE BEVER, Hervé et al

in International Journal of Critical Illness and Injury Science (2014), 4(2), 108-113

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See detailGas dissolution in antibubble dynamics
scheid, benoit; zawala, jan; Dorbolo, Stéphane ULg

in Soft Matter (2014), 10

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See detailmiRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization.
Valencia, Karmele; Luis-Ravelo, Diego; Bovy, Nicolas ULg et al

in Molecular oncology (2014), 8(3), 689-703

Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a ... [more ▼]

Bone metastasis represents one of the most deleterious clinical consequences arising in the context of many solid tumors. Severe osteolysis results from tumor cell colonization of the bone compartment, a process which entails reciprocal exchange of soluble signals between tumor cells and their osseous microenvironment. Recent evidence indicates that tumor-intrinsic miRNAs are pleiotropic regulators of gene expression. But they are also frequently released in exosome-like vesicles (ELV). Yet the functional relevance of the transference of tumor-derived ELV and their miRNA cargo to the extracellular milieu during osseous colonization is unknown. Comparative transcriptomic profiling using an in vivo murine model of bone metastasis identified a repressed miRNA signature associated with high prometastatic activity. Forced expression of single miRNAs identified miR-192 that markedly appeased osseous metastasis in vivo, as shown by X-ray, bioluminescence imaging and microCT scans. Histological examination of metastatic lesions revealed impaired tumor-induced angiogenesis in vivo, an effect that was associated in vitro with decreased hallmarks of angiogenesis. Isolation and characterization of ELV by flow cytometry, Western blot analysis, transmission electron microscopy and nanoparticle tracking analysis revealed the ELV cargo enrichment in miR-192. Consistent with these findings, fluorescent labeled miR-192-enriched-ELV showed the in vitro transfer and release of miR-192 in target endothelial cells and abrogation of the angiogenic program by repression of proangiogenic IL-8, ICAM and CXCL1. Moreover, in vivo infusion of fluorescent labeled ELV efficiently targeted cells of the osseous compartment. Furthermore, treatment with miR-192 enriched ELV in a model of in vivo bone metastasis pre-conditioned osseous milieu and impaired tumor-induced angiogenesis, thereby reducing the metastatic burden and tumor colonization. Changes in the miRNA-cargo content within ELV represent a novel mechanism heavily influencing bone metastatic colonization, which is most likely relevant in other target organs. Mechanistic mimicry of this phenomenon by synthetic nanoparticles could eventually emerge as a novel therapeutic approach. [less ▲]

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See detailDensity estimates and nesting-site selection in chimpanzees of the Nimba Mountains, Côte d'Ivoire and Guinea
Granier, Nicolas ULg; Hambuckers, Alain ULg; Matsuzawa et al

in American Journal of Primatology (2014)

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked ... [more ▼]

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked 80 km of transects and recces each month, and recorded 764 nests (mean group size = 2.23 nests) along with characteristics of vegetation structure and composition, topography and seasonality. Population density estimated with two nest count methods ranged between 0.14 and 0.65 chimpanzee/km2. These values are lower than previous estimates, emphasizing the necessity of protecting remaining wild ape populations. Chimpanzees built nests in 108 tree species out of 437 identified, but 2.3% of total species comprised 52% of nests. Despite they preferred nesting in trees of 25-29 cm DBH and at a mean height of 8.02 m, we recorded an important proportion of terrestrial nests (8.2%) that may reflect a cultural trait of Nimba chimpanzees. A logistic model of nest presence formulated as a function of 12 habitat variables revealed preference for gallery and mountain forests rather than lowland forest, and old-growth forest rather than secondary forests. They nested more frequently in the study area during the dry season (December-April). The highest probability of observing nests was at 770 m altitude, particularly in steep locations (mean ground declivity = 15.54%). Several of the reported nest characteristics combined with the existence of 2 geographically separated clusters of nest, suggest that the study area constitutes the non-overlapping peripheral areas of 2 distinct communities. This nest-based study led us to findings on the behavioral ecology of Nimba chimpanzees, which constitute crucial knowledge to implement efficient and purpose-built conservation. [less ▲]

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See detailSeasonal and depth-related biodiversity of leaf epiphytic Cheilostome Bryozoa in a Mediterranean Posidonia oceanica meadow
Lepoint, Gilles ULg; Balancier, Boris; Gobert, Sylvie ULg

in Cahiers de Biologie Marine (2014), 55(1),

: Epiphytes living fixed on Posidonia oceanica L. (Delile) are important faunal and floral components of seagrass meadow ecosystems. They are involved as main actors in trophic web and major ecosystem ... [more ▼]

: Epiphytes living fixed on Posidonia oceanica L. (Delile) are important faunal and floral components of seagrass meadow ecosystems. They are involved as main actors in trophic web and major ecosystem processes of this endangered coastal habitat. This paper aims to assess the seasonality and the bathymetric variability of epiphytic Bryozoa which are the most important animal group in terms of both diversity and abundance living on P. oceanica leaves. Posidonia shoots were collected from the Revellata Bay (Corsica, France) in four seasons from 7 to 30 m depth. Colony densities reached more than 87000 colonies. m-2 at 10 m depth in spring. The bryozoan species distribution and abundance changed substantially according to seasons and depths, being maximum in spring and minimal in winter. Dominant colony morphotypes change according to depth, probably in relation with water motion gradient. This confirms that there are bathymetric and seasonal variability for different epiphytic organisms colonizing the Posidonia leaves. This enlightens the importance to protect Posidonia meadow on its full depth extension and in its connectivity with other habitats to conserve optimal epiphytic biodiversity and functions. [less ▲]

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See detailQuel universalisme des droits de l'homme?
Delruelle, Edouard ULg

in Revue Trimestrielle des Droits de l'Homme [= RTDH] (2014), 98

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See detailUpdate of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance Certification Exam.
Petersen, Steffen E.; Almeida, Ana G.; Alpendurada, Francisco et al

in European heart journal cardiovascular Imaging (2014), 15(7), 728-729

An updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The ... [more ▼]

An updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The syllabus lists key elements of knowledge in CMR. It represents a framework for the development of training curricula and provides expected knowledge-based learning outcomes to the CMR trainees, in particular those intending to demonstrate CMR knowledge in the European CMR exam, a core requirement in the CMR certification process. [less ▲]

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See detailOn the policy implications of changing longevity
Pestieau, Pierre ULg; Ponthiere, Grégory ULg

in CESifo Ecoonmic Studies (2014), 60

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See detailEffects of glucose-lowering agents on vascular outcomes in type 2 diabetes: A critical reappraisal.
Scheen, André ULg; Charbonnel, B.

in Diabetes & metabolism (2014)

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major ... [more ▼]

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain how hyperglycaemia induces vascular damage. However, randomized controlled trials investigating either an intensive glucose-lowering strategy vs standard care or the addition of a new glucose-lowering agent vs a placebo have largely failed to demonstrate any clinical benefits in terms of cardiovascular morbidity or mortality. This lack of evidence has led some people to contest the clinical efficacy of lowering blood glucose in patients with T2DM, despite its positive effects on microvascular complications. This article analyzes the various reasons that might explain such discrepancies. There are still strong arguments in favour of targeting hyperglycaemia while avoiding other counterproductive effects, such as hypoglycaemia and weight gain, and of integrating the glucose-lowering approach within a global multi-risk strategy to reduce the burden of cardiovascular disease in T2DM. [less ▲]

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See detailA patient-specific airway branching model for mechanically ventilated patients.
Damanhuri, Nor Salwa; Docherty, Paul D.; Chiew, Yeong Shiong et al

in Computational and mathematical methods in medicine (2014), 2014

Background. Respiratory mechanics models have the potential to guide mechanical ventilation. Airway branching models (ABMs) were developed from classical fluid mechanics models but do not provide accurate ... [more ▼]

Background. Respiratory mechanics models have the potential to guide mechanical ventilation. Airway branching models (ABMs) were developed from classical fluid mechanics models but do not provide accurate models of in vivo behaviour. Hence, the ABM was improved to include patient-specific parameters and better model observed behaviour (ABMps). Methods. The airway pressure drop of the ABMps was compared with the well-accepted dynostatic algorithm (DSA) in patients diagnosed with acute respiratory distress syndrome (ARDS). A scaling factor (alpha) was used to equate the area under the pressure curve (AUC) from the ABMps to the AUC of the DSA and was linked to patient state. Results. The ABMps recorded a median alpha value of 0.58 (IQR: 0.54-0.63; range: 0.45-0.66) for these ARDS patients. Significantly lower alpha values were found for individuals with chronic obstructive pulmonary disease (P < 0.001). Conclusion. The ABMps model allows the estimation of airway pressure drop at each bronchial generation with patient-specific physiological measurements and can be generated from data measured at the bedside. The distribution of patient-specific alpha values indicates that the overall ABM can be readily improved to better match observed data and capture patient condition. [less ▲]

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See detailA bittersweet symphony.
Daly, Adrian ULg; Beckers, Albert ULg

in Endocrine-related cancer (2014)

This issue sees the publication of work expanding the range of how genetic dysregulation of SDHx genes can cause cancer syndromes with a prominent endocrine component, in this case Carney triad, which is ... [more ▼]

This issue sees the publication of work expanding the range of how genetic dysregulation of SDHx genes can cause cancer syndromes with a prominent endocrine component, in this case Carney triad, which is characterized by gastrointestinal stromal tumors (GIST), paraganglioma and pulmonary chondromas. [less ▲]

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See detailModelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study.
Frippiat, Frederic; Musuamba, Flora Tshinanu; Seidel, Laurence ULg et al

in The Journal of antimicrobial chemotherapy (2014)

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in ... [more ▼]

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial pneumonia, 30 were assigned to intermittent infusion (II; over 0.5 h) and 25 to extended infusion (EI; over 3 h) groups. Based on plasma and epithelial lining fluid (ELF) concentrations determined at steady-state, pharmacokinetic modelling and Monte Carlo simulations were undertaken to assess the probability of attaining drug concentrations above the MIC for 40%-100% of the time between doses (%T > 1-fold and 4-fold MIC), for 1 or 2 g administered by either method. RESULTS: Penetration ratio, measured by the ELF/plasma ratio of AUCs, was statistically higher in the EI group than in the II group (mean +/- SEM: 0.29 +/- 0.030 versus 0.20 +/- 0.033, P = 0.047). Considering a maximum susceptibility breakpoint of 2 mg/L, all dosages and modes of infusions achieved 40%-100% T > 1-fold MIC in plasma, but none did so in ELF, and only the 2 g dose over EI achieved 40%-100% T > 4-fold MIC in plasma. CONCLUSIONS: The optimum regimen to treat severe nosocomial pneumonia was 2 g of meropenem infused over 3 h every 8 h. This regimen achieved the highest pharmacodynamic targets both in plasma and in ELF. [less ▲]

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See detailSurprising causes of C5-carnitine false positive results in newborn screening.
BOEMER, François ULg; SCHOOS, Roland ULg; de HALLEUX, Virginie ULg et al

in Molecular genetics and metabolism (2014), 111(1), 52-4

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we ... [more ▼]

During an 18-month period, we noticed an alarming increase of newborn screening false positivity rate in identifying isovaleric acidemia. In 50 of 50 newborns presenting elevated C5-carnitine, we confirmed the presence of pivaloylcarnitine. Exogenous pivalate administration had been previously identified as the causal agent of this concern. No pivalic-ester prodrug is commercially available in Belgium, but pivalic derivates are also used in the cosmetic industry as emollient under the term "neopentanoate". We have identified neopentanoate-esters in a nipple-fissure unguent that was provided to young mothers. Ceasing distribution of this product hugely reduced the C5-carnitine false positivity rate. [less ▲]

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See detailIntroduction aux problèmes inverses
Charles, Catherine ULg

in Notes de Statistique et d'Informatique (2014)

cette note technique est une inititation aux problèmes inverses. Son objectif est d'expliquer au lecteur ses principes généraux, de montrer son large panel d'applications ainsi que de présenter ses ... [more ▼]

cette note technique est une inititation aux problèmes inverses. Son objectif est d'expliquer au lecteur ses principes généraux, de montrer son large panel d'applications ainsi que de présenter ses méthodes de résolution les plus courantes. [less ▲]

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See detailLearning from our European imaging colleagues.
Weissman, Neil J.; Lancellotti, Patrizio ULg

in JACC. Cardiovascular imaging (2014), 7(6), 639-40

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See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

in European Financial Management (2014), forthcoming

This paper singles out the key roles of US equity skewness and kurtosis in the hedge fund return generating process. We propose a conditional higher-moment model with location, trading, and higher-moment ... [more ▼]

This paper singles out the key roles of US equity skewness and kurtosis in the hedge fund return generating process. We propose a conditional higher-moment model with location, trading, and higher-moment factors to describe the dynamics of the equity hedge, event-driven, relative value, and fund of funds styles. If the volatility, skewness, and kurtosis implied in US options are used by fund managers as instruments to anticipate market movements, managers should adjust their market exposure in response to variations in these moments. We indeed show that higher-moment premia improve the conditional asset pricing model across all hedge fund styles. [less ▲]

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See detailDynamic seasonal nitrogen cycling in response to anthropogenic N loading in a tropical catchment, Athi–Galana–Sabaki River, Kenya
Marwick, T. R.; Tamooh, F.; Ogwoka, B. et al

in Biogeosciences (2014), 11(2), 443--460

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See detailEmotional Facial Expression Recognition and Expressivity in Type I and Type II Alcohol Dependent Patients
Dethier, Marie ULg; El Hawa, Maya; Duchateau et al

in Journal of Nonverbal Behavior (2014), 38(1), 89-105

Objective: Alcohol dependent patients (ADs) are known to encounter severe interpersonal problems. Nonverbal communication skills are important for the development of healthy relationships. The present ... [more ▼]

Objective: Alcohol dependent patients (ADs) are known to encounter severe interpersonal problems. Nonverbal communication skills are important for the development of healthy relationships. The present study aimed to explore emotional facial expression (EFE) recognition and posed and spontaneous EFE expressivity in male ADs divided into two groups according to Cloninger’s typology and the impact of their interpersonal relationship quality on the potential nonverbal deficits. Method: Twenty type I ADs, twenty-one type II ADs, and twenty control participants took part in an EFE recognition task and an EFE expressivity task that considered personal emotional events (spontaneous expressivity) and EFE in response to a photo or word cue (posed expressivity). Coding was based on judges’ ratings of participants’ emotional facial expressions. Participants additionally completed a questionnaire on interpersonal relationship quality. Results: No difference between the three groups emerged in the EFE recognition task. Type II ADs showed heightened deficits compared with type I ADs in EFE expressivity: Judges perceived less accurate posed EFE in response to a cue word and less intense and positive spontaneous EFE in type II ADs compared to control participants. In addition, type II ADs reported more relationship difficulties compared to both type I ADs and control participants. These interpersonal relationship difficulties were related to some of the EFE expressivity deficits of AD-IIs. Conclusions: This study underlines the important differences between the interpersonal functioning of AD subtypes. [less ▲]

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See detailObservation <–> Text(e) <–> Culture. Introduction
Badir, Sémir ULg

in Semiotica (2014), 198

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See detailIron loss calculation in steel laminations at high frequencies
Henrotte, François; Steentjes, Simon; Hameyer, Kay et al

in IEEE Transactions on Magnetics (2014), 50(2), 333-336

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See detailThinking out of the box - New approaches to controlling GVHD
Baron, Frédéric ULg; Humblet-Baron, Stéphanie; Ehx, Grégory ULg et al

in Current Hematologic Malignancy Reports (2014), 9

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD ... [more ▼]

Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to bebased on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatmentsstill relies on high-dose corticosteroids. Further, no second line treatment has emerged thus far in acute or chronic GVHD patients who failed on corticosteroids. After briefly reviewing current standards of GVHD prevention and treatment, this article will discuss recent approaches that might change GVHD prophylaxis / treatment in the next decades, with a special focus on recently developed immunoregulatory strategies based on infusion of mesenchymal stromal or regulatory T-cells, or on injection of lowdose interleukin-2. [less ▲]

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See detailEffectiveness of PHARMAceutical care for patients with COPD (PHARMACOP): a randomized controlled trial
Tommelein, Eline; Mehuys, Els; Van Hees, Thierry ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 756-766

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary ... [more ▼]

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary Disease (COPD) have been conducted. We assessed the effectiveness of a pharmaceutical care program for patients with COPD. METHODS: The PHARMACOP-trial is a single-blind 3-month RCT, conducted in 170 community pharmacies in Belgium, enrolling patients prescribed daily COPD medication, aged >/=50 years, and with a smoking history >/=10 pack-years. A computer-generated randomization sequence allocated patients to intervention (n=371), receiving protocol-defined pharmacist care, or control group (n=363), receiving usual pharmacist care (1:1 ratio, stratified by center). Interventions, focusing on inhalation technique and adherence to maintenance therapy, were carried out at start of the trial and at one month follow-up. Primary outcomes were inhalation technique and medication adherence. Secondary outcomes were exacerbation rate, dyspnea, COPD specific and generic health status and smoking behavior. RESULTS: From December 2010 to April 2011, 734 patients were enrolled. 42 patients (5.7%) were lost to follow-up. At the end of the trial, inhalation score (Mean estimated difference [Delta],13.5%; 95% Confidence Interval [CI], 10.8-16.1; P<.0001) and medication adherence (Delta, 8.51%; 95%CI, 4.63-12.4; P<.0001) were significantly higher in the intervention group compared to the control group. In the intervention group, a significantly lower hospitalization rate was observed (9 vs 35; Rate Ratio, 0.28; 95%CI, 0.12-0.64; P=.003). No other significant between-group differences were observed. CONCLUSION: Pragmatic pharmacist care programs improve the pharmacotherapeutic regime in patients with COPD and could reduce hospitalization rates. [less ▲]

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See detailCrystal Structure of the Extended-Spectrum β -Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β -Lactams and β -Lactamase Inhibitors
Ruggiero, Melina; Kerff, Frédéric ULg; Herman, Raphaël ULg et al

in Antimicrobial Agents and Chemotherapy (2014), 58(10), 5994-6002

PER-2 belongs to a small (7 members to date) group of extended-spectrum beta-lactamases. It has 88% amino acid identity with PER-1 and both display high catalytic efficiencies toward most beta-lactams. In ... [more ▼]

PER-2 belongs to a small (7 members to date) group of extended-spectrum beta-lactamases. It has 88% amino acid identity with PER-1 and both display high catalytic efficiencies toward most beta-lactams. In this study, we determined the X-ray structure of PER-2 at 2.20 A and evaluated the possible role of several residues in the structure and activity toward beta-lactams and mechanism-based inhibitors. PER-2 is defined by the presence of a singular trans bond between residues 166 to 167, which generates an inverted Omega loop, an expanded fold of this domain that results in a wide active site cavity that allows for efficient hydrolysis of antibiotics like the oxyimino-cephalosporins, and a series of exclusive interactions between residues not frequently involved in the stabilization of the active site in other class A beta-lactamases. PER beta-lactamases might be included within a cluster of evolutionarily related enzymes harboring the conserved residues Asp136 and Asn179. Other signature residues that define these enzymes seem to be Gln69, Arg220, Thr237, and probably Arg/Lys240A ("A" indicates an insertion according to Ambler's scheme for residue numbering in PER beta-lactamases), with structurally important roles in the stabilization of the active site and proper orientation of catalytic water molecules, among others. We propose, supported by simulated models of PER-2 in combination with different beta-lactams, the presence of a hydrogen-bond network connecting Ser70-Gln69-water-Thr237-Arg220 that might be important for the proper activity and inhibition of the enzyme. Therefore, we expect that mutations occurring in these positions will have impacts on the overall hydrolytic behavior. [less ▲]

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See detailError rate for imputation from the Illumina BovineSNP50 chip to the Illumina BovineHD chip.
Schrooten, Chris; Dassonneville, Romain; Ducrocq, Vincent et al

in Genetics, Selection, Evolution (2014), 46(1), 10

BACKGROUND: Imputation of genotypes from low-density to higher density chips is a cost-effective method to obtain high-density genotypes for many animals, based on genotypes of only a relatively small ... [more ▼]

BACKGROUND: Imputation of genotypes from low-density to higher density chips is a cost-effective method to obtain high-density genotypes for many animals, based on genotypes of only a relatively small subset of animals (reference population) on the high-density chip. Several factors influence the accuracy of imputation and our objective was to investigate the effects of the size of the reference population used for imputation and of the imputation method used and its parameters. Imputation of genotypes was carried out from 50 000 (moderate-density) to 777 000 (high-density) SNPs (single nucleotide polymorphisms). METHODS: The effect of reference population size was studied in two datasets: one with 548 and one with 1289 Holstein animals, genotyped with the Illumina BovineHD chip (777 k SNPs). A third dataset included the 548 animals genotyped with the 777 k SNP chip and 2200 animals genotyped with the Illumina BovineSNP50 chip. In each dataset, 60 animals were chosen as validation animals, for which all high-density genotypes were masked, except for the Illumina BovineSNP50 markers. Imputation was studied in a subset of six chromosomes, using the imputation software programs Beagle and DAGPHASE. RESULTS: Imputation with DAGPHASE and Beagle resulted in 1.91% and 0.87% allelic imputation error rates in the dataset with 548 high-density genotypes, when scale and shift parameters were 2.0 and 0.1, and 1.0 and 0.0, respectively. When Beagle was used alone, the imputation error rate was 0.67%. If the information obtained by Beagle was subsequently used in DAGPHASE, imputation error rates were slightly higher (0.71%). When 2200 moderate-density genotypes were added and Beagle was used alone, imputation error rates were slightly lower (0.64%). The least imputation errors were obtained with Beagle in the reference set with 1289 high-density genotypes (0.41%). CONCLUSIONS: For imputation of genotypes from the 50 k to the 777 k SNP chip, Beagle gave the lowest allelic imputation error rates. Imputation error rates decreased with increasing size of the reference population. For applications for which computing time is limiting, DAGPHASE using information from Beagle can be considered as an alternative, since it reduces computation time and increases imputation error rates only slightly. [less ▲]

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See detailUse of sapropterin dihydrochloride in maternal phenylketonuria. A European experience of eight cases.
Feillet, Francois; Muntau, Ania C.; DEBRAY, François-Guillaume ULg et al

in Journal of inherited metabolic disease (2014)

Sapropterin dihydrochloride (SD) is the first drug treatment for phenylketonuria (PKU), but due to the lack of data, its use in maternal PKU must be undertaken with caution as noted in the FDA and EMEA ... [more ▼]

Sapropterin dihydrochloride (SD) is the first drug treatment for phenylketonuria (PKU), but due to the lack of data, its use in maternal PKU must be undertaken with caution as noted in the FDA and EMEA labels. We collected data from eight pregnancies in PKU women treated with SD and we analysed the phenotypes of these patients, their tetrahydrobiopterin (BH4) responsiveness, the indications for SD treatment, the efficacy (metabolic control, phenylalanine (Phe) tolerance and offspring outcome) and the safety data. Results showed that in the seven patients known to be responsive to BH4, the use of SD during pregnancy was efficient in terms of metabolic control and Phe tolerance. The indications for giving SD included the failure of the low-Phe diet (n = 3), the fact that some of these women had never experienced the low Phe diet (n = 2), one unexpected pregnancy in a woman currently on SD and one pregnancy where the foetus was known to have PKU. The offspring of these seven pregnancies were all normal babies with normal birth measurements and outcomes. No side effect related to SD was observed in these seven cases. In the eighth case, SD was prescribed as a rescue treatment without previous knowledge of the BH4 responsiveness to a woman who was already 8 weeks pregnant without diet. The birth occurred at 33 weeks of gestational age with Potter syndrome (probably related to the absence of metabolic control during the first trimester) and the baby died in the first hours of life. In conclusion, the data presented here provides the first evidence that treatment with pharmacological doses of SD appears to be efficient and safe in women with PKU during pregnancy. Its use should, however, be restricted to those women previously identified to be clear responders to BH4. [less ▲]

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See detailPatterns of tree species composition across tropical African forests
Fayolle, Adeline ULg; Swaine, Michael D.; Bastin, Jean-François ULg et al

in Journal of Biogeography (2014), online

Aim : In this study we identified large-scale variation in tree species composition across tropical African forests and determined the underlying environmental and historical factors. Location : Tropical ... [more ▼]

Aim : In this study we identified large-scale variation in tree species composition across tropical African forests and determined the underlying environmental and historical factors. Location : Tropical forests from Senegal to Mozambique. Methods : Distribution data were gathered for 1175 tree species in 455 sample sites scattered across tropical Africa, including all types of tropical forests (wet, moist, dry, and lowland to moderate elevation montane forests). The value of elevation and 19 climatic variables extracted from the BIOCLIM data set were assigned to each sample site. We determined the variation in species composition using correspondence analysis and identified the environmental correlates. We defined floristic clusters according to species composition and identified the characteristic species using indicator analysis. Results : We identified a major floristic discontinuity located at the Albertine rift that separated the dry, moist and wet forests of West and Central Africa (the entire Guineo-Congolian Region) from the upland and coastal forests of East Africa. Except for the Albertine Rift, we found no evidence to support the other proposed floristic discontinuities (Dahomey Gap etc.). We detected two main environmental gradients across tropical African forests. The rainfall gradient was strongly correlated with the variation in tree species composition in West and Central Africa. The elevation/temperature gradient highlighted the major floristic differences within East Africa and between East Africa and the Guineo-Congolian Region, the latter being most probably due to the geological disruption and associated climatic history of the East African uplift. Main conclusions : We found floristic evidence for three main biogeographical regions across the tropical African forests, and described six floristic clusters with particular environmental conditions within these regions: Coastal and Upland for East Africa, Dry and Wet-Moist for West Africa, and Moist and Wet for Central Africa. [less ▲]

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See detailCharacterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogel
Haghgoo, Majid; Yousefi, Ali Akbar; Zohouriaan Mehr, Mohammad Jalal et al

in Microporous and Mesoporous Materials (2014), 184

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See detailHuman bone marrow, umbilical cord or liver mesenchymal stromal cells fail to improve liver function in a model of CCl4-induced liver damage in NOD/SCID/IL-2Ry(null) mice
BRIQUET, Alexandra ULg; GREGOIRE, Céline ULg; Comblain, Fanny ULg et al

in Cytotherapy (2014), 16

Background aims. Transplantation is the gold standard procedure for treating acute and chronic end-stage liver diseases. Given the shortage of organs, the development of cellular sources other than human ... [more ▼]

Background aims. Transplantation is the gold standard procedure for treating acute and chronic end-stage liver diseases. Given the shortage of organs, the development of cellular sources other than human liver is urgent. The main objective of this project was to examine the effect of mesenchymal stromal cell (MSC) (bone marrow, umbilical cord and liver MSCs) intravenous injection on liver regeneration in a model of hepatic damage in NOD/SCID/IL non-obese diabetic/severe combined immunodeficient/Interleukin-2Rg(null) (NSG) mice. Methods. Mice received 3 intraperitoneal injections of CCl4 Carbon tetrachloride per week for 4 weeks. Forty-eight hours after the last injection of CCl4, mice received 500,000 MSCs or phosphate-buffered saline by intravenous injection. We examined hepatic damage by means of quantitative image analysis and blood enzyme analysis 24 h, 1 week or 8 weeks after MSC or phosphate-buffered saline injection. We also examined MSC homing by means of real-time polymerase chain reaction of human albumin. Results. We adapted a model of liver injury in immunodeficient mice. In this model, accumulation of collagen in newly formed scar septa was apparent up to 8 weeks after CCl4 treatment. Human albumin DNA was found in all organs tested. However, intravenous MSC injection, even after CXCR4 C-X-C chemokine receptor type 4 transduction and whatever the origin of MSCs, failed to improve liver damage. Conclusions. In this liver injury model, MSCs were propagated in various tissues, particularly filtering organs. For the treatment of hepatic damage, intravenous administration of moderate doses of MSCs does not appear to be effective. Yet, this adapted liver injury model is appropriate for investigating engraftment of human cells. [less ▲]

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See detailPlanting teak, Tectona grandis L.f., in smallholder farming systems in Southern Benin
Aoudji, Augustin K. N.; Adégbidi, Anselme; Ganglo, Jean C. et al

in Bois et Forêts des Tropiques (2014), (1er trimestre 2014/n° 319), 7-17

This article used the farming system framework to characterise smallholder plantings of teak, Tectona grandis L.f., in southern Benin. The intention of this study was to show the policy line best suited ... [more ▼]

This article used the farming system framework to characterise smallholder plantings of teak, Tectona grandis L.f., in southern Benin. The intention of this study was to show the policy line best suited to capturing the potential of smallholder forestry. The specific question addressed was as follows: how do smallholder farmers manage to integrate tree growing on their farms? Empirical assessments were based on a sample of 221 farmers selected through a cluster sampling procedure in five municipalities in the Atlantic district. Data were collected from face-to-face interviews based on a standardised questionnaire. A multivariate approach associating cluster analysis and Principal Component Analysis (PCA) was used to build a typology of teak planting systems. This was based on production objectives, the teak plantation area, overall farm size and the contribution of family labour to timber production. The study enabled to identify three planting systems related to different strategies for integrating teak planting on smallholdings. These planting systems were classified as “small - labour dominant” (33.48% of the sample), “medium - capital dominant” (37.56%), and “large - capital dominant” (28.96%). The farmers specialised in pole-wood production to supply urban demand for cheap construction timber in the region. The first three motivations for growing teak were to earn income, to satisfy household timber needs and to secure title to the land; however, the ranking of the last two motivations was reversed among farmers in the “large - capital dominant” planting system. Secure land tenure and the existence of a domestic market outlet are essential to successful development of on-farm tree growing. [less ▲]

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See detailComprehensive plasma profiling for the characterization of graft-versus-host disease biomarkers
De Bock, Muriel; BEGUIN, Yves ULg; Leprince, Pierre ULg et al

in Talanta (2014), 125

Acutegraft-versus-hostdisease(aGVHD)remainsalife-threateningcomplicationofhematopoieticstem cell transplantation(HSCT)thereforelimitingitsapplication.TooptimizethemanagementofaGVHDand reduce therapy ... [more ▼]

Acutegraft-versus-hostdisease(aGVHD)remainsalife-threateningcomplicationofhematopoieticstem cell transplantation(HSCT)thereforelimitingitsapplication.TooptimizethemanagementofaGVHDand reduce therapy-relatedtoxicity,earlyspecific markersareneeded.Themainobjectiveofthisstudywas to uncoverdiagnosticbiomarkersbycomparingplasmaproteinprofiles ofpatientsatthetimeofacute GVHDdiagnosiswiththoseofpatientsundergoingHSCTwithoutaGVHD.Additionalanalysisofsamples taken 15daysbeforeaGVHDdiagnosiswasalsoperformedtoevaluatethepotentialofournewly discoveredbiomarkersforearlydiagnosis.Togetcomplementaryinformationfromplasmasamples, we usedthreedifferentproteomicapproaches,namely2D-DIGE,SELDI-TOF-MSand2D-LC-MSE. Weidentified andconfirmed bythemeansofindependenttechniques,thedifferentialexpression of severalproteinsindicatingsignificantly increasedinflammation responseanddisturbanceinthe coagulation cascade.Thevariationoftheseproteinswasalreadyobserved15daysbeforeGVHD diagnosis, suggestingthepotentialearlydetectionofthediseasebeforesymptomsappearance. Finally,logisticregressionanalysisdeterminedacompositebiomarkerpanelcomprising fibrinogen, fragment of fibrinogenbetachain,SAA,prothrombinfragments,apolipoproteinA1andhepcidinthat optimallydiscriminatedpatientswithandwithoutGVHD.Theareaunderthereceiveroperating characteristiccurvedistinguishingthese2groupswas0.95. [less ▲]

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See detailMyocardial dynamic contrast-enhanced MR: vascular diseases and beyond
NCHIMI LONGANG, Alain ULg; DJEKIC, Julien; RASKINET, Bruno et al

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2014), 97

Contrast-enhanced cardiac magnetic resonance enables the evaluation of both myocardial perfusion and its composition. This paper reviews and discusses the conditions that cause abnormal findings on ... [more ▼]

Contrast-enhanced cardiac magnetic resonance enables the evaluation of both myocardial perfusion and its composition. This paper reviews and discusses the conditions that cause abnormal findings on contrast-enhanced myocardial magnetic resonance. Their knowledge helps in most cases to avoid inappropriate referrals to invasive imaging in patients suspected of myocardial vascular disease, undergoing contrast-enhanced cardiac magnetic resonance. [less ▲]

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See detailNew mutations in ADC-type beta-lactamases from Acinetobacter spp. affect cefoxitin and ceftazidime hydrolysis.
Perez, Astrid; Perez-Llarena, Francisco Jose; Garcia, Patricia et al

in The Journal of antimicrobial chemotherapy (2014)

OBJECTIVES: Two natural variants of ADC-type beta-lactamases of Acinetobacter spp., ADC-1 and ADC-5, differ by nine mutations in their protein sequence. ADC-5 hydrolyses cefoxitin better than ADC-1 and ... [more ▼]

OBJECTIVES: Two natural variants of ADC-type beta-lactamases of Acinetobacter spp., ADC-1 and ADC-5, differ by nine mutations in their protein sequence. ADC-5 hydrolyses cefoxitin better than ADC-1 and the opposite is true for ceftazidime. We produced single and combined mutations in ADC-5 and characterized the variants microbiologically and biochemically to determine which amino acid residues are involved in the hydrolysis of beta-lactam antibiotics in this family of beta-lactamases. METHODS: Site-directed mutagenesis, with blaADC-5 as a source of DNA, was used to generate nine single mutated and three combined mutated enzymes. The proteins (wild-type and derivatives) were then expressed in isogenic conditions in Escherichia coli. MICs of beta-lactams were determined using Etest strips. ADC-1, ADC-5, ADC-5-P167S and ADC-5-P167S/D242G/Q163K/G342R were also purified and the kinetic parameters determined for ceftazidime, cefoxitin, cefalotin and ampicillin. RESULTS: Single mutations did not significantly convert the hydrolysis spectrum of the ADC-5 enzyme into that of the ADC-1 enzyme, although among all studied mutants only the quadruple mutant (ADC-5-P167S/D242G/Q163K/G342R) displayed microbiological and biochemical properties consistent with those of ADC-1. CONCLUSIONS: Although some single mutations are known to affect cefepime hydrolysis in ADC-type beta-lactamases, little is known about ceftazidime and cefoxitin hydrolysis in this family of beta-lactamases. Hydrolysis of these antibiotics appears to be positively and negatively affected, respectively, by the Q163K, P167S, D242G and G342R amino acid replacements. [less ▲]

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See detailDecrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial.
Henrotin, Yves; Henrotin, Yves ULg

in BMC Complimentary & Alternative Medicine (2014)

The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring ... [more ▼]

The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring both disease activity and treatment efficacy. Curcumin is basically a spice that is known for its anti-inflammatory properties. In vitro studies suggest that curcumin could be beneficial for cartilage in OA. The aim of this exploratory, non-controlled clinical trial was to evaluate the effects of bio-optimized curcumin in knee OA patients on the serum levels of specific biomarkers of OA and on the evaluation of pain. This study highlighted the potential effect of curcumin in knee OA patient. This effect was reflected by the variation of a cartilage specific biomarker, Coll2-1 that was rapidly affected by the treatment. These results are encouraging for the qualification of Coll2-1 as a biomarker for the evaluation of curcumin in OA treatment. (Trial registration: NCT01909037 at clinicaltrials.gov) [less ▲]

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See detailNew Amphiphilic Neamine Derivatives Active against Resistant Pseudomonas aeruginosa and Their Interactions with Lipopolysaccharides
Sautrey, Guillaume; Zimmerman, Louis; Deleu, Magali ULg et al

in Antimicrobial Agents and Chemotherapy (2014), 58(8), 4420-4430

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See detaildeltaPlotR: An R package for differential item functioning analysis with Angoff's Delta Plot
Magis, David ULg; Facon, Bruno

in Journal of Statistical Software (2014), 59(1), 1-19

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by ... [more ▼]

Angoff's delta plot is a straightforward and not computationally intensive method to identify differential item functioning (DIF) among dichotomously scored items. This approach was recently improved by proposing an optimal threshold selection and by considering several item purification processes. Moreover, to support practical DIF analyses with the delta plot and these improvements, the R package deltaPlotR was also developed. The purpose of this paper is twofold: to outline the delta plot by describing the original method and its recent improvements in a user-oriented way, and to illustrate the structure and performances of the deltaPlotR package. A real data set about language skill assessment is being analyzed as an illustrative example. [less ▲]

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See detailConnecting the dots for social value: A review on social networks and social entrepreneurship
Dufays, Frédéric ULg; Huybrechts, Benjamin ULg

in Journal of Social Entrepreneurship (2014), 5(2), 214-237

The emergence of social entrepreneurship has been explained at the macro-level (socioeconomic drivers), at the meso-level (concepts such as opportunity), and at the micro-level (motivations and intentions ... [more ▼]

The emergence of social entrepreneurship has been explained at the macro-level (socioeconomic drivers), at the meso-level (concepts such as opportunity), and at the micro-level (motivations and intentions of social entrepreneurs). In this conceptual article, it is argued that the sociology of social networks may contribute to explain how and why social entrepreneurship arises by bridging micro- and macro-levels of analysis. Four different usages of the social network concept in the social entrepreneurship literature are identified: embeddedness of social entrepreneurship, collective social entrepreneurship, networking as a critical skill or activity of social entrepreneurship, and finally networking and the creation of social capital as a goal of social entrepreneurship. Theoretical frameworks explaining the emergence of conventional entrepreneurship with a social network lens are identified. These are evaluated with regard to social entrepreneurship and translated into a set of research proposals to be explored in order to strengthen our understanding of social entrepreneurship emergence. [less ▲]

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See detailCarotid artery and aortic stiffness evaluation in aortic stenosis.
Weisz, Sara Hana; Magne, Julien ULg; Dulgheru, Raluca et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2014), 27(4), 385-92

BACKGROUND: In aortic stenosis (AS), the combination of risk factors can progressively lead to an increased arterial rigidity, which can be evaluated by the carotid artery and aortic stiffness (beta index ... [more ▼]

BACKGROUND: In aortic stenosis (AS), the combination of risk factors can progressively lead to an increased arterial rigidity, which can be evaluated by the carotid artery and aortic stiffness (beta index). The aim of this study was to investigate the relationship between carotid and aortic beta index, left ventricular (LV) function, plasma brain natriuretic peptide (BNP) level, and symptoms in patients with AS. METHODS: Comprehensive echocardiography including Doppler tissue imaging of the mitral annulus was performed in 53 patients with AS (aortic valve area < 1.2 cm(2)) and preserved LV ejection fractions (>/=50%). Carotid beta index was automatically derived from ultrasound wall tracking of the right carotid artery. The mitral E/e' ratio was used to estimate LV filling pressures. RESULTS: Carotid beta index was higher in women than in men and was significantly correlated with age (P < .0001), diastolic arterial pressure (P = .046), pulse pressure (P = .006), and systemic arterial compliance (P = .001). Interestingly, carotid beta index was significantly correlated with E/e' ratio (P < .0001) and plasma BNP level (P = .011). In multivariate regression analysis, carotid beta index was an independent predictor of E/e' ratio (P < .0001) and of BNP level (P = .02). Moreover, carotid beta index was significantly higher in symptomatic patients (P = .009). Aortic beta index was significantly correlated with carotid beta index (P < .0001), E/e' ratio (P = .004), and BNP (P < .001) and was significantly higher in symptomatic patients (P = .037). CONCLUSIONS: In patients with moderate to severe AS and preserved LV ejection fractions, the presence of increased carotid artery and aortic stiffness, assessed using carotid and aortic beta index, is independently associated with elevated LV filling pressures, BNP level, and symptoms. [less ▲]

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See detailBouncing dynamics of a spring
Hubert, Maxime ULg; Ludewig, François ULg; Dorbolo, Stéphane ULg et al

in Physica D: Nonlinear Phenomena (2014), 272

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See detailCR de Anna Drzewicka, "Volez oïr…". Études sur la littérature française du Moyen Âge, Articles des années 1974-2008
Henrard, Nadine ULg

in Bulletin Bibliographique de la Société Rencesvals (2014), 2013-2014(45), 208-212

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See detailA methodological evaluation of volumetric measurement techniques including three-dimensional imaging in breast surgery
HOEFFELIN, Harry; JACQUEMIN, Denise ULg; Defaweux, Valérie ULg et al

in BioMed Research International (2014), 2014

Breast surgery currently remains very subjective and each intervention depends on the ability and experience of the operator. To date, no objective measurement of this anatomical region can codify surgery ... [more ▼]

Breast surgery currently remains very subjective and each intervention depends on the ability and experience of the operator. To date, no objective measurement of this anatomical region can codify surgery. In this light, we wanted to compare and validate a new technique for 3D scanning (LifeViz 3D) and its clinical application. Materials and methods. - We tested the use of the 3D LifeViz system (Quantificare) to perform volumetric calculations in various settings ("in situ" in cadaveric dissection, of control prostheses and in clinical patients) and we compared this system to other techniques (CT scanning and Archimedes' principle) under the same conditions. Results. - We were able to identify the benefits (feasibility, safety, portability, low patient stress) and limitations (underestimation of the “in situ” volume, subjectivity of contouring, and patient selection) of the LifeViz 3D system, concluding that the results are comparable with other measurement techniques. Conclusion. - The prospects of this technology seem promising in numerous applications in clinical practice to limit the subjectivity of breast surgery. [less ▲]

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See detailAn effective finite-element-based method for the computation of nonlinear normal modes of nonconservative systems
Renson, Ludovic ULg; Deliège, Geoffrey ULg; Kerschen, Gaëtan ULg

in Meccanica (2014), 49(8), 1901-1916

This paper addresses the numerical computation of nonlinear normal modes defined as two-dimensional invariant manifolds in phase space. A novel finite-element-based algorithm, combining the streamline ... [more ▼]

This paper addresses the numerical computation of nonlinear normal modes defined as two-dimensional invariant manifolds in phase space. A novel finite-element-based algorithm, combining the streamline upwind Petrov-Galerkin method with mesh moving and domain prediction-correction techniques, is proposed to solve the manifold-governing partial differential equations. It is first validated using conservative examples through the comparison with a reference solution given by numerical continuation. The algorithm is then demonstrated on nonconservative examples. [less ▲]

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See detailDetermination of the Al2O3 content in NaF-AlF 3-CaF2-Al2O3 melts at 950 °c by raman spectroscopy
Malherbe, Cédric ULg; Eppe, Gauthier ULg; Gilbert, Bernard ULg

in Analytical Chemistry (2014)

Thein situ control of the chemical composition of industrial aluminum smelter is a challenge mainly for physicochemical reasons: high temperature, high surrounding electromagnetic field, and the highly ... [more ▼]

Thein situ control of the chemical composition of industrial aluminum smelter is a challenge mainly for physicochemical reasons: high temperature, high surrounding electromagnetic field, and the highly corrosive molten salt electrolyte to deal with. In previous works, we proposed that Raman spectroscopy is a method of choice that could be adapted to real smelters. The laboratory study presented here relies on reproducible Raman spectra recorded on molten mixtures whose compositions are identical to those used during the production of aluminum. A normalization procedure for the Raman spectra is proposed based on the equilibria taking place in the bath. In addition, we discuss two quantitative models to determine the alumina content from the Raman spectra of the molten NaF−AlF3−CaF2−Al2O3 electrolytes. Univariate and multivariate approaches are applied to determine both theCOx (alumina content) and the CR (NaF/AlF3 molar ratio) by Raman spectroscopy without referring to an additional internal reference of intensity. The procedure was successfully tested and validated on industrial samples. [less ▲]

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See detailThe mitochondrial respiratory chain of the secondary green alga Euglena gracilis shares many additional subunits with parasitic Trypanosomatidae.
Perez, Emilie ULg; Lapaille, Marie; Degand, Herve et al

in Mitochondrion (2014)

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential ... [more ▼]

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential therapeutic target. Recently, numerous additional subunits of the respiratory-chain complexes have been described in Trypanosoma brucei and Trypanosoma cruzi. Since these subunits had apparently no counterparts in other organisms, they were interpreted as potentially associated with the parasitic trypanosome lifestyle. Here we used two complementary approaches to characterise the subunit composition of respiratory complexes in Euglena gracilis, a non-parasitic secondary green alga related to trypanosomes. First, we developed a phylogenetic pipeline aimed at mining sequence databases for identifying homologs to known respiratory-complex subunits with high confidence. Second, we used MS/MS proteomics after two-dimensional separation of the respiratory complexes by Blue Native- and SDS-PAGE to both confirm in silico predictions and to identify further additional subunits. Altogether, we identified 41 subunits that are restricted to E. gracilis, T. brucei and T. cruzi, along with 48 classical subunits described in other eukaryotes (i.e. plants, mammals and fungi). This moreover demonstrates that at least half of the subunits recently reported in T. brucei and T. cruzi are actually not specific to Trypanosomatidae, but extend at least to other Euglenozoa, and that their origin and function are thus not specifically associated with the parasitic lifestyle. Furthermore, preliminary biochemical analyses suggest that some of these additional subunits underlie the peculiarities of the respiratory chain observed in Euglenozoa. [less ▲]

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See detailCorrection of vitamin D insufficiency with combined strontium ranelate and vitamin D3 in osteoporotic patients.
Rizzoli, R.; Dawson-Hughes, B.; Kaufman, J.-M. et al

in European Journal of Endocrinology (2014), 170(3), 441-50

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D ... [more ▼]

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D insufficiency in osteoporosis. DESIGN: A 6-month international, randomized, double-blind, parallel-group, phase 3 study. METHODS: A total of 518 men and postmenopausal women aged >/=50 years with primary osteoporosis (T-score </=-2.5 s.d.) and serum 25-hydroxyvitamin D (25(OH)D) >22.5 nmol/l were included. Patients were allocated to strontium ranelate 2 g/vitamin D3 1000 IU daily (n=413) or strontium ranelate 2 g daily (n=105). The participants received calcium 1 g daily. The primary endpoint was serum 25(OH)D at last post-baseline evaluation during 3 months. RESULTS: Both groups were comparable at baseline. Mean baseline of 25(OH)D was 44.1+/-14.6 nmol/l. After 3 months, the percentage of patients with 25(OH)D >/=50 nmol/l was higher with strontium ranelate/vitamin D3 vs strontium ranelate (84 vs 44%, P<0.001; adjusted between-group odds ratio=6.7; 95% CI, 4.2-10.9). The efficacy of the fixed-dose combination on 25(OH)D was maintained at 6 months (86 vs 40%, P<0.001). Mean 25(OH)D was 65.1 and 49.5 nmol/l, respectively, after 3 months and 66.9 and 45.4 nmol/l after 6 months. Physical performance improved in both groups. Falls were 17 and 20% in the strontium ranelate/vitamin D3 and strontium ranelate groups respectively. Parathyroid hormone levels were inversely correlated with 25(OH)D. No clinically relevant differences in safety were observed. CONCLUSIONS: This study confirms the efficacy and safety of fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU for correction of vitamin D insufficiency in osteoporotic patients. [less ▲]

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See detailBuilding a validation measure for activity-based transportation models based on mobile phone data
Liu, Feng; Janssens, Davy; Cui, JianXun et al

in Expert Systems with Applications (2014), 41(14), 6174-6189

Activity-based micro-simulation transportation models typically predict 24-h activity-travel sequences for each individual in a study area. These sequences serve as a key input for travel demand analysis ... [more ▼]

Activity-based micro-simulation transportation models typically predict 24-h activity-travel sequences for each individual in a study area. These sequences serve as a key input for travel demand analysis and forecasting in the region. However, despite their importance, the lack of a reliable benchmark to evaluate the generated sequences has hampered further development and application of the models. With the wide deployment of mobile phone devices today, we explore the possibility of using the travel behavioral information derived from mobile phone data to build such a validation measure. Our investigation consists of three steps. First, the daily trajectory of locations, where a user performed activities, is constructed from the mobile phone records. To account for the discrepancy between the stops revealed by the call data and the real location traces that the user has made, the daily trajectories are then transformed into actual travel sequences. Finally, all the derived sequences are classified into typical activity-travel patterns which, in combination with their relative frequencies, define an activity-travel profile. The established profile characterizes the current activity-travel behavior in the study area, and can thus be used as a benchmark for the assessment of the activity-based transportation models. By comparing the activity-travel profiles derived from the call data with statistics that stem from traditional activity-travel surveys, the validation potential is demonstrated. In addition, a sensitivity analysis is carried out to assess how the results are affected by the different parameter settings defined in the profiling process. [less ▲]

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See detailEditorial
Bourgeois, Marc ULg

in Revue de Fiscalité Régionale et Locale (2014), Liv. 1

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See detailHost-induced bacterial cell wall decomposition mediates pattern-triggered immunity in Arabidopsis
Liu, X.; Grabherr, H.; Willmann, R. et al

in eLife (2014)

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See detailSeismically-triggered organic-rich layers in recent sediments from lake Gollukoy (North Anatolian Fault, Turkey
Avşar, Ulaş; Hubert, Aurelia ULg; De Batist, Marc et al

in Quaternary Science Reviews (2014), 103

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See detailExtinction de l'hypothèque pour toutes créances futures par suite de la cessation de la relation bancaire ?
Biquet, Christine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2014), (5), 223-224

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See detailMapping French terms in a Belgian guideline on heart failure to international classifications and nomenclatures: the devil is in the detail.
Jamoulle, Marc ULg; Cardillo, Elena; Roumier, Joseph et al

in Informatics in Primary Care (2014), accepted

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies ... [more ▼]

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies more stringent demands on the quality of data-entry at the point-of-care. Non-native English speaking general practitioners experience difficulties in interacting with international classification systems and nomenclatures to facilitate the secondary use of their data and to ensure semantic interoperability. Aim: To identify words and phrases pertaining to the heart failure domain and to explore the difficulties in mapping to corresponding concepts in ICPC-2, ICD-10, SNOMED-CT, and UMLS. Methods: The medical concepts in a Belgian guideline for General Practitioners (GPs) in its French version were extracted manually and coded first in ICPC-2, then ICD-10 by a physician, an expert in classification systems. In addition, mappings were sought with SNOMED-CT and UMLS concepts, using the UMLS SNOMED-CT browser. Results: We retained 143 words and phrases, of which 128 referred to a single concept (1-to-1 mapping), while 15 referred to 2 or more concepts (1-to-n mapping to ICPC rubrics or to the other nomenclatures). In the guideline, words or phrases were often too general for adequate correspondence. Marked discrepancy between semantic tags and types was found. Conclusion: This study illustrates the variability of the various international classifications and nomenclatures, the need for structured guidelines with more attention to precise wording, and the need for classification expertise embedded in sophisticated terminological resources. End-users need support to perform their clinical work in their own language, while still assuring standardized and semantic interoperable medical registration. Collaboration between computational linguists, knowledge engineers, health informaticians and domain experts is needed. [less ▲]

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See detailSECOND ORDER SYMMETRIES OF THE CONFORMAL LAPLACIAN
Michel, Jean-Philippe ULg; Radoux, Fabian ULg; Silhan, Josef

in Symmetry, Integrability and Geometry: Methods and Applications [=SIGMA] (2014), 10(016), 26

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by ... [more ▼]

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by differential operators of second order. They are constructed from conformal Killing 2-tensors satisfying a natural and conformally invariant condition. As a consequence, we get also the classification of the second order symmetries of the conformal Laplacian. Our results generalize the ones of Eastwood and Carter, which hold on conformally flat and Einstein manifolds respectively. We illustrate our results on two families of examples in dimension three. [less ▲]

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See detailPolitical Participation of Latin American Migrants in Andalusia: Opportunities and Constraints
Bermudez Torres, Anastasia ULg; Escriva, Angeles; Moraes, Natalia

in Migraciones Internacionales (2014), 7(3), 73-98

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The ... [more ▼]

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The project uses a broad concept of what political participation constitutes, including both civic practices and activities associated with conventional politics, and adopts a transnational perspective. It is based on 45 semi-structured interviews with politically active migrants and members of political parties and other institutions. The article highlights some of the main findings of the research, including the importance of taking into account migrants’ previous political experiences, as well as the role played by migrant associations in order to better understand their political practices. [less ▲]

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