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See detailEvidence of a fine-scale genetic structure for the endangered Pyrenean desman (Galemys pyrenaicus) in the French Pyrenees
Gillet, F; Cabria, M.; Blanc, F. et al

in Journal of Mammalogy (2017)

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing mountain streams. This species is currently classified as vulnerable on the IUCN Red List and has been undergoing habitat loss and fragmentation for decades, inevitably impacting its distribution. A recent genetic study, based on mitochondrial and intronic sequences, showed that the genetic variability of the Pyrenean desman is very low in the Pyrenees. In this study, we investigated the potential existence of genetic structure and gene flow at a smaller scale using 24 polymorphic microsatellite loci. As the Pyrenean desman is a very elusive species, we supplemented our tissue sample collection with samples of feces collected in the French range of this species. We successfully identified 70 individuals based on 355 fecal samples. Bayesian analyses revealed 3 genetic and geographic clusters (1 eastern, 1 central, and 1 western, including 3 genetic sub-clusters), with origins tracing back only 200 years. These clusters were characterized by low levels of genetic diversity and high inbreeding coefficients. Although gene flow among clusters appeared to be limited, populations seem to have exchanged alleles recently. Therefore, connectivity between watersheds should be enhanced to maintain genetic diversity and potentially improve the long-term survival of the Pyrenean desman in France [less ▲]

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See detailLa mise en œuvre du droit de plainte en Belgique francophone. Observation des processus de médiation en soins de santé
Dubois, Christophe ULg; Vandeninden, Elise ULg

in Revue Française des Affaires Sociales (2017), 1(1), 79-96

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the ... [more ▼]

This article concerns the treatment of patients’ rights cases in French‐speaking Belgian hospitals by the “mediator”, that is, the person who has the legal duty of dealing with grievances arising from the application of this right of complaint. What happens to a patient’s complaint? This is the question that this article attempts to answer through a report on the “local” organization of mediation ser‐ vices within the hospital. It thus clari es the links and divergences between the formal discourses accompanying the implementation of the mediation function in health care on the one hand, and, on the other hand, the actual practices of media‐ tion determined by the work of mediators in the hospital. [less ▲]

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See detailPest regulation and support of natural enemies in agriculture: Experimental evidence of within field wildflower strips
Hatt, Séverin ULg; Chevalier Mendes Lopes, Thomas ULg; Boeraeve, Fanny ULg et al

in Ecological Engineering (2017), 98

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for ... [more ▼]

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for today’sagriculture. The aim of this study was to assess whether the two strategies of complicating the search ofhost plants by pests by increasing plant diversity, and of supporting their natural enemies by managinghabitats, could be combined simultaneously at the field scale to restore biological pest control and reducechemical insecticide use. In Gembloux (Belgium), wildflower strips (WFS) were sown within wheat cropsin which pests (i.e., aphids), their predators (i.e. aphidophagous hoverflies, lacewings and ladybeetles)and parasitoid wasps were monitored for 10 weeks in the period of May through July 2015 as indicatorsof the ES of pest control. Aphids were significantly reduced and adult hoverflies favoured in wheat inbetween WFS, compared to monoculture wheat plots. No significant differences were observed for adultlacewings, ladybeetles and parasitoids. In all treatments, very few lacewing and ladybeetle larvae wereobserved on wheat tillers. The abundance of hoverfly larvae was positively correlated with the aphid den-sity on tillers in between WFS, showing that increasing food provisions by multiplying habitats withinfields, and not only along margins, can help supporting aphidophagous hoverflies in crops. By enhancingthe ecosystem services of biological pest control, this study shows that increasing both plant diversityand managing habitats for natural enemies may reduce aphid populations, hence insecticide use. Futureresearch should continue this vein of work by quantifying the link between agricultural practices and thedelivery of ecosystem services in order to guide future measures of agricultural policies. [less ▲]

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See detailL’IMAGE DU MOIS.Une tumeur cardiaque indéterminée
RADERMECKER, Régis ULg; RENSON, Virginie ULg; Delvenne, Philippe ULg et al

in Revue Médicale de Liège (2017), 72(1), 4-5

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See detailChemical composition, vasorelaxant, antioxidant and antiplatelet effects of essential oil of Artemisia campestris L. from Oriental Morocco
Dib, Ikram; Fauconnier, Marie-Laure ULg; Sindic, Marianne ULg et al

in BMC Complementary and Alternative Medicine (2017), 17(art. 82), 1-15

Background: Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A ... [more ▼]

Background: Artemisia campestris L. (Asteraceae) is a medicinal herb traditionally used to treat hypertension and many other diseases. Hence, this study is aimed to analyze the essential oil of A. campestris L (AcEO) and to investigate the antiplatelet, antioxidant effects and the mechanisms of its vasorelaxant effect. Methods: The chemical composition of AcEO was elucidated using GC/MS analysis. Then, the antioxidant effect was tested on DPPH radical scavenging and on the prevention of β-carotene bleaching. The antiplatelet effect was performed on the presence of the platelet agonists: thrombin and ADP. The mechanism of action of the vasorelaxant effect was studied by using the cellular blockers specified to explore the involvement of NO/GC pathway and in the presence of calcium channels blockers and potassium channels blockers. Results: AcEO is predominated by the volatiles: spathulenol, ß-eudesmol and p-cymene. The maximal antioxidant effect was obtained with the dose 2 mg/ml of AcEO. The dose 1 mg/ml of AcEO showed a maximum antiplatelet effect of, respectively 49.73% ±9.54 and 48.20% ±8.49 on thrombin and ADP. The vasorelaxation seems not to be mediated via NOS/GC pathway neither via the potassium channels. However, pretreatment with calcium channels blockers attenuated this effect, suggesting that the vasorelaxation is mediated via inhibition of L-type Ca2+ channels and the activation of SERCA pumps of reticulum plasma. Conclusion: This study confirms the antioxidant, antiplatelet and vasorelaxant effects of A.campestris L essential oil. However, the antihypertensive use of this oil should be further confirmed by the chemical fractionation and subsequent bio-guided assays. [less ▲]

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See detailThe structure and variability of Mars dayside thermosphere from MAVEN NGIMS and IUVS measurements: Seasonal and solar activity trends in scale heights and temperatures
Bougher, S. W.; Roeten, K. J.; Olsen, K. et al

in Journal of Geophysical Research. Space Physics (2017)

Mars dayside thermospheric temperature and scale height trends were examined using measurements from the Neutral Gas Ion Mass Spectrometer (NGIMS) and the Imaging Ultraviolet Spectrograph (IUVS) on the ... [more ▼]

Mars dayside thermospheric temperature and scale height trends were examined using measurements from the Neutral Gas Ion Mass Spectrometer (NGIMS) and the Imaging Ultraviolet Spectrograph (IUVS) on the Mars Atmosphere Volatile EvolutioN (MAVEN) spacecraft. Average scale heights (over 150-180 km for solar zenith angles ≤75°) from several different sampling periods were obtained from each instrument. NGIMS and IUVS scale height trends were found to be in good agreement, with both showing scale heights decreasing after perihelion and reaching a low value near aphelion (13.6 to 9.4 km). Between these two seasonal extremes, the temperature decreased by ∼70 K (from 240 to 170 K). These trends were also analyzed with respect to the changing solar flux reaching the planet, using the Lyman alpha irradiance measured by the Extreme Ultraviolet Monitor (EUVM) on MAVEN. Scale heights responded strongly to the changing solar flux. During this part of the MAVEN mission (October 2014 to May 2016), it was concluded that over longer timescales (at least several months), dayside thermospheric temperatures are chiefly driven by changing solar forcing, although it is the effects of changing heliocentric distance rather than changing solar activity which seem to have the greatest impact. Furthermore, effects of solar forcing were not observed on shorter timescales (less than a month), suggesting local wave effects may dominate solar forcing on these timescales. Finally, temperatures from two NGIMS sampling periods were compared to temperatures from the Mars Global Ionosphere-Thermosphere Model (M-GITM) and found to be in good agreement. © 2017. American Geophysical Union. All Rights Reserved. [less ▲]

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See detailConcise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.
Franco, Benedicte; Malgrange, Brigitte ULg

in Stem cells (Dayton, Ohio) (2017)

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice ... [more ▼]

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice harbor some progenitor cells that retain the ability to give rise to new hair cells. These progenitor cells are in fact supporting cells. Upon hair cells loss, those cells are able to generate new hair cells both by direct transdifferentiation or following cell cycle re-entry and differentiation. However, this property of supporting cells is progressively lost after birth. Here, we review the molecular mechanisms that are involved in mammalian hair cell development and regeneration. Manipulating pathways used during development constitute good candidates for inducing hair cell regeneration after injury. Despite these promising studies, there is still no evidence for a recovery following hair cells loss in adult mammals. Stem Cells 2017. [less ▲]

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See detailWalnut husk fly, Rhagoletis completa (Diptera: Tephritidae), invades Europe: invasion potential and control strategies
Verheggen, François ULg; Verhaeghe, Agnès; Giordanengo, Philippe et al

in Applied Entomology and Zoology (2017), 52(1), 1-7

Rhagoletis completa Cresson (Diptera: Tephritidae) is native to North America and invaded Western Europe in the late 1980s, causing important damage to its principal host, walnut (Juglans spp.). In this ... [more ▼]

Rhagoletis completa Cresson (Diptera: Tephritidae) is native to North America and invaded Western Europe in the late 1980s, causing important damage to its principal host, walnut (Juglans spp.). In this review, we summarize the important elements of R. completa’s biology, phytosanitary status and methods used in Europe for its control, and then present the main conclusions associated with a completed risk analysis performed in 2014 to evaluate the dispersion and establishment potential of R. completa in Europe. The walnut husk fly was initially identified in Switzerland (1988) and Italy (1991), from where it spread to at least seven additional countries: France, Spain, Germany, Austria, Croatia, Slovenia and Hungary. R. completa has not reached the limits of its potential distribution. The main dissemination pathways within Europe include: (1) natural adult dissemination; (2) adult hitchhiker behaviour; and, to a lesser extent, (3) transportation of larvae in fresh fruits. R. completa host plants are widely distributed in Europe, either as isolated wild trees or in orchards, favouring the probability of fly establishment in currently fly-free areas. In addition, the European territories where Juglans species are present share biogeographic similarities. In orchards where R. completa is present and uncontrolled, 100% of walnut trees can be infested, causing losses in walnut yields of up to 80%. The negative effect is low (<10% yield loss) under phytosanitary control, although additional costs must also be considered to support specific monitoring for R. completa. The information presented here underlines a strong need for better walnut husk fly monitoring across European countries, as well as for increasing efforts to develop biological methods to control this emerging pest. [less ▲]

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See detailEffects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study
Gaul, Charly; MAGIS, Delphine ULg; Liebler, Eric et al

in Journal of Headache and Pain (2017), 18

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve ... [more ▼]

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study. Findings: After a 2-week baseline phase, 97 patients with chronic cluster headache entered a 4-week randomised phase to receive nVNS + SoC (n = 48) or SoC alone (n = 49). All 92 patients who continued into a 4-week extension phase received nVNS + SoC. Compared with SoC alone, nVNS + SoC led to a significantly lower mean weekly attack frequency by week 2 of the randomised phase; the attack frequency remained significantly lower in the nVNS + SoC group through week 3 of the extension phase (P < 0.02). Attack frequencies in the nVNS + SoC group were significantly lower at all study time points than they were at baseline (P < 0.05). Response rates were significantly greater with nVNS + SoC than with SoC alone when response was defined as attack frequency reductions of ≥25%, ≥50%, and ≥75% from baseline (≥25% and ≥50%, P < 0.001; ≥75%, P = 0.009). The 100% response rate was 8% with nVNS + SoC and 0% with SoC alone. Conclusions: Prophylactic nVNS led to rapid, significant, and sustained reductions in chronic cluster headache attack frequency within 2 weeks after its addition to SoC and was associated with significantly higher ≥25%, ≥50%, and ≥75% response rates than SoC alone. The rapid decrease in weekly attack frequency justifies a 4-week trial period to identify responders to nVNS, with a high degree of confidence, among patients with chronic cluster headache. [less ▲]

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See detailOptimization and validation of a fast Supercritical Fluid Chromatography method for the quantitative determination of vitamin D3 and its related impurities.
Andri, Bertyl ULg; Lebrun, Pierre ULg; Dispas, Amandine ULg et al

in Journal of Chromatography. A (2017)

In the uprising context of green analytical chemistry, Supercritical Fluid Chromatography (SFC) is often suggested as an alternative to Normal Phase Liquid Chromatography. Indeed, SFC provides fast ... [more ▼]

In the uprising context of green analytical chemistry, Supercritical Fluid Chromatography (SFC) is often suggested as an alternative to Normal Phase Liquid Chromatography. Indeed, SFC provides fast, efficient and green separations. In this report, the quantitative performances of SFC were challenged on a real-life case study: the Quality Control (QC) of vitamin D3. A rapid and green SFC method was optimized thanks to the Design of Experiments–Design Space (DoE–DS) methodology. It provided robust and high quality separation of the compounds within a 2 min timeframe, using a gradient of ethanol as co-solvent of the carbon dioxide. The analytical method was fully validated according to the total error approach, demon- strating the compliance of the method to the specifications of U.S. Pharmacopeia (USP: 97.0–103.0%) and European Pharmacopeia (EP: 97.0–102.0%) for an interval of [50–150%] of the target concentration. In order to allow quantification of impurities using vitamin D3 as an external standard in SFC-UV, correction factors were determined and verified during method validation. Thus, accurate quantification of impu- rities was demonstrated at the specified levels (0.1 and 1.0% of the main compound) for a 70.0–130.0% dosing range. This work demonstrates the validity of an SFC method for the QC of vitamin D3 raw material and its application to real samples. Therefore, it supports the switch to a greener and faster separative technique as an alternative to NPLC in the pharmaceutical industry. [less ▲]

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See detailComparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure
Bertrand, Henri ULg; Springer, Svenja; Burnside, Wesley et al

in Laboratory Animals (2017)

Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery ... [more ▼]

Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery than iso- flurane in a number of species, but no comparisons have been made in non-human primates. This study compared the recovery characteristics of isoflurane and sevoflurane in rhesus macaques undergoing experi- mental neurosurgery. Twelve primates (7 males and 5 females) were randomly allocated to the treatment groups. They were sedated with ketamine (10 mg/kg) and anaesthesia was induced with propofol (usually 8 mg/kg intravenously [IV]). Anaesthesia was maintained with either sevoflurane (SEVO) (2.2 0.4%) or iso- flurane (ISO) (1.2 0.2%) and alfentanil (0.2–0.5 mg/kg/min IV) for 332–592 min. Animals were mechanically ventilated. Meloxicam (0.3mg/kg) and methylprednisolone infusion (5.4mg/kg/h) were also administered. Time to extubation after cessation of anaesthesia was significantly shorter with sevoflurane (ISO: 7.0 1.8 min; SEVO: 3.6 1.5; *P 1⁄4 0.005) as was the time to the animal sitting unaided (ISO: 15.7 8.2 min; SEVO: 7.1 1.7min; *P1⁄40.004). No significant difference in the quality of recovery following isoflurane or sevoflurane anaesthesia was found. In conclusion, isoflurane and sevoflurane are both suitable volatile agents for the maintenance of general anaesthesia in rhesus macaques undergoing experimental neurosur- gical procedures. The two volatile agents presented a similar emergence quality profile, however sevoflurane anaesthesia was associated with a faster recovery, offering the possibility of conducting earlier post-operative neurological assessment. [less ▲]

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See detailChanges in biophysical membrane properties induced by the Budesonide/ Hydroxy-β-cyclodextrin complex
dos Santos, Andreia; Bayiha, Jules; Dufour, Gilles et al

in BBA Biomembranes (2017)

Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a ... [more ▼]

Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a biocompatible cyclodextrin known to interact with cholesterol, is used as a drug-solubilizing agent in pharmaceutical formulations. Budesonide administered as an inclusion complex within HPβCD (BUD:HPβCD) required a quarter of the nominal dose of the suspension formulation and significantly reduced neutrophil induced inflammation in a COPD mouse model exceeding the effect of each molecule administered individually. This suggests the role of lipid domains enriched in cholesterol for inflammatory signaling activation. In this context, we investigated the effect of BUD:HPβCD on the biophysical properties of membrane lipids. On cellular models (A549, lung epithelial cells), BUD:HPβCD extracted cholesterol similarly to HPβCD. On large unilamellar vesicles (LUVs), by using the fluorescent probes diphenylhexatriene (DPH) and calcein, we demonstrated an increase in membrane fluidity and permeability induced by BUD:HPβCD in vesicles containing cholesterol. On giant unilamellar vesicles (GUVs) and lipid monolayers, BUD:HPβCD induced the disruption of cholesterol-enriched raft-like liquid ordered domains as well as changes in lipid packing and lipid desorption from the cholesterol monolayers, respectively. Except for membrane fluidity, all these effects were enhanced when HPβCD was complexed with budesonide as compared with HPβCD. Since cholesterol-enriched domains have been linked to membrane signaling including pathways involved in inflammation processes, we hypothesized the effects of BUD:HPβCD could be partly mediated by changes in the biophysical properties of cholesterol-enriched domains. [less ▲]

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See detailMetabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach
Govinden-Soulange, J.; Lobine, D.; Frederich, Michel ULg et al

in South African Journal of Botany (2017), 108

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect ... [more ▼]

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. Nuclear magnetic resonance spectroscopy, DNA sequencing and antioxidant profiles of these Aloes were studied. Principal component analysis following 1H NMR revealed the specificity of the Mascarene Aloes relative to Aloe vera. The superior free radical scavenging ability of A. purpurea, A. macra and A. tormentorii as compared to other Aloes was also unveiled. Phylogenetic analyses of chloroplast genes and ITS region sequences of these Mascarene Aloes were done using maximum parsimony and Bayesian analysis. Mascarene Aloes clustered within one clade separate from Aloe vera confirming their relative recent emergence in this genus. Results from this study showed that there is sufficient evidence at the metabolomic and molecular level to distinguish between Aloe ​purpurea from Mauritius and that of Reunion. © 2016 SAAB [less ▲]

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See detailRelations on words
Rigo, Michel ULg

in Indagationes Mathematicae (2017), 28

In the first part of this survey, we present classical notions arising in combinatorics on words: growth function of a language, complexity function of an infinite word, pattern avoidance, periodicity and ... [more ▼]

In the first part of this survey, we present classical notions arising in combinatorics on words: growth function of a language, complexity function of an infinite word, pattern avoidance, periodicity and uniform recurrence. Our presentation tries to set up a unified framework with respect to a given binary relation. In the second part, we mainly focus on abelian equivalence, $k$-abelian equivalence, combinatorial coefficients and associated relations, Parikh matrices and $M$-equivalence. In particular, some new refinements of abelian equivalence are introduced. [less ▲]

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See detailFormaliser le trope : De la subjectivité linguistique à la subjectivité épilinguistique
Mathy, Adrien ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

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See detailThe link between self-perceptions of aging, cancer view and physical and mental health of older people with cancer: A cross-sectional study
Schroyen, Sarah ULg; Marquet, Manon ULg; Jerusalem, Guy ULg et al

in Journal of Geriatric Oncology (2017)

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has ... [more ▼]

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has never been studied in the elderly population. Similarly, even though it is established that a negative self-perception of aging has deleterious consequences on mental and physical health in normal aging, the influence in pathological contexts, such as oncology, has not been studied. The main aim of this study is thus to analyze the effect of these two stigmas on the health of elderly oncology patients. Materials and Methods 101 patients suffering from a cancer (breast, gynecological, lung or hematological) were seen as soon as possible after their diagnosis. Their self-perception of age, cancer view and health (physical and mental) was assessed. Results Multiple regressions showed that patients with a more negative self-perception of aging and/or more negative cancer view reported poorer global health. We also observed that negative self-perception of aging was associated with worse physical and mental health, whereas negative cancer views were only linked to worse mental health. No interaction was observed between these two stigmas, suggesting that their action is independent. Conclusion Older patients with cancer face double stigmatization, due to negative self-perception of aging and cancer, and these stigmas have impacts on global and mental health. Self-perception of aging is also linked to physical health. Longitudinal studies will be necessary to analyze the direction of the association between this double stigmatization and health. [less ▲]

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See detailEmbedded solids of any dimension in the X-FEM. Part II - Imposing Dirichlet boundary conditions
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series ... [more ▼]

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. While the first paper is devoted to the design of a dedicated P1 function space to solve elliptic equations defined on manifolds of codimension one or two (curves in 2D and surfaces in 3D, or curves in 3D), the general treatment of Dirichlet boundary conditions, in such a setting, remains to be addressed. This is the aim of this second paper. A new algorithm is introduced to build a stable Lagrange multiplier space from the traces of the shape functions defined on the background mesh. It is general enough to cover: (i) boundary value problems investigated in the first paper (with, for instance, Dirichlet boundary conditions defined along a line in a 3D mismatching mesh); but also (ii) those posed on manifolds of codimension zero (a domain embedded in a mesh of the same dimension) and already considered in Béchet et al. 2009. In both cases, the compatibility between the Lagrange multiplier space and that of the bulk approximation (the dedicated P1 function space used in (i), or classical shape functions used in (ii)) — resulting in the inf–sup condition — is investigate through the numerical Chapelle-Bath test. Numerical validations are performed against analytical and finite element solutions on problems involving 1D or 2D boundaries embedded in a 2D or 3D background mesh. Comparisons with Nitsche’s method and the stable Lagrange multiplier space proposed in Hautefeuille et al. 2012, when they are feasible, highlight good performance of the approach. [less ▲]

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See detailJuno-UVS Approach Observations of Jupiter's Auroras
Gladstone, G. R.; Versteeg, M. H.; Greathouse, T. K. et al

in Geophysical Research Letters (2017)

Juno-UVS observations of Jupiter's aurora obtained during approach are presented. Prior to the bow-shock crossing on 24 June 2016, the Juno approach provided a rare opportunity to correlate local solar ... [more ▼]

Juno-UVS observations of Jupiter's aurora obtained during approach are presented. Prior to the bow-shock crossing on 24 June 2016, the Juno approach provided a rare opportunity to correlate local solar wind conditions with Jovian auroral emissions. Some of Jupiter's auroral emissions are expected to be controlled or modified by local solar wind conditions. Here we compare synoptic Juno-UVS observations of Jupiter's auroral emissions, acquired during 3-29 June 2016, with in situ solar wind observations, and related Jupiter observations from Earth. Four large auroral brightening events are evident in the synoptic data, in which the total emitted auroral power increases by a factor of 3-4 for a few hours. Only one of these brightening events correlates well with large transient increases in solar wind ram pressure. The brightening events which are not associated with the solar wind generally have a rise time of ~2 hours and a decay time of ~5 hours. [less ▲]

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See detailSystemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD.
Stolz, Daiana; Leeming, Diana Julie; Edfort Kristensen, Jacob Hull et al

in CHEST (2017)

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic ... [more ▼]

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic obstructive pulmonary disease (COPD). We aimed to assess the association of ECM turnover with severity and outcome of COPD. METHODS: In a prospective, observational, multicenter study including 506 patients with COPD, GOLD grades II-IV, we analyzed serum samples at stable state, exacerbation and 4 weeks after exacerbation, for a panel of 5 novel neo-epitopes including fragments of collagen type-III (C3M) and type-VI (C6M), pro-forms of collagen type-III (Pro-C3) and type-VI (Pro-C6) and neutrophil elastase-generated fragments of elastin (EL-NE) by ELISA. These neo-epitopes were also measured at stable state in a derivation cohort including 100 COPD patients. RESULTS: Serum levels of C3M, C6M, Pro-C3, Pro-C6 and EL-NE were associated with lung function. Patients with the lowest levels of Pro-C3 and Pro-C6 had more severe airflow limitation, hyperinflation, air trapping, and emphysema. Degradation of collagen type-III and -VI was associated with dyspnea. All ECM biomarkers, except Pro-C6, were increased at exacerbation as compared to stable state but, except EL-NE, did not differ between stable state and exacerbation follow-up in the crude and adjusted analyses. In Cox regression adjusted analyses, Pro-C3 was associated with a shorter time to exacerbation (HR 0.72[0.59-0.89] p=0.002) and Pro-C6 with survival (HR 2.09[1.18-3.71], p=0.011). CONCLUSIONS: Serum biomarkers of ECM turnover are significantly associated with disease severity and clinically relevant outcomes in COPD. [less ▲]

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See detailThe same but different: stable isotopes reveal two distinguishable, yet similar, neighbouring food chains in a coral reef
Le Bourg, Baptiste ULg; Letourneur, Yves; Bănaru, Daniela et al

in Journal of the Marine Biological Association of the United Kingdom (2017)

Stable isotope compositions were studied in particulate organic matter (POM), zooplankton and different trophic groups of teleosts to compare food chains based on plankton at two sites (lagoon and outer ... [more ▼]

Stable isotope compositions were studied in particulate organic matter (POM), zooplankton and different trophic groups of teleosts to compare food chains based on plankton at two sites (lagoon and outer slope) in a New Caledonian coral reef. For each trophic compartment, d13C values were always lower in the outer slope than in the lagoon. This result may be explained by potential differences in POM composition between the two environments, suggesting that the two food chains are based on different primary sources of carbon. In contrast, d15N values did not vary between the lagoon and the outer slope, indicating that these two food chains presented similar length and trophic levels, despite being distinguishable. [less ▲]

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See detailTroubles du comportement alimentaire et régulation émotionnelle
Englebert, Jérôme ULg

in Psychosomatique Relationnelle (2017), 7

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See detailSwimmer's Itch in Belgium: First Recorded Outbreaks, Molecular Identification of the Parasite Species and Intermediate Hosts.
Caron, Yannick ULg; Cabaraux, Ariane; Marechal, Francoise et al

in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2017)

BACKGROUND: Cercarial dermatitis or swimmer's itch is a skin condition in humans due to the larval forms of bird schistosomes of some species of the genus Trichobilharzia. The life cycle of these ... [more ▼]

BACKGROUND: Cercarial dermatitis or swimmer's itch is a skin condition in humans due to the larval forms of bird schistosomes of some species of the genus Trichobilharzia. The life cycle of these schistosomes requires freshwater snails (intermediate host) and waterfowl (definitive host). Repeated exposures to cercariae can lead to skin sensitization with the induction of pruritic skin lesions. METHODS: We describe, in this study, two outbreaks of human cercarial dermatitis at the Eau d'Heure Lakes, Belgium. In July and August 2012, a total of, respectively, 78 and 10 people reported a sudden skin rash accompanied by pruritus following recreational activities in the Plate Taille Lake. However, no ocellate furcocercariae were detected following light exposure of the snails collected between September 2012 and September 2013 (n = 402). No outbreaks were recorded in 2013 and 2014. In August 2015, about 30 new cases were recorded. Snails were collected (n = 270) in different locations around the lake. PCR was used to identify accurately the intermediate hosts and the parasite species involved. RESULTS: After light exposure, seven Radix spp. (2.6%) shed ocellate furcocercariae. Molecular identification based on the rDNA internal transcribed spacer 2 sequence ascribed the infected snails to R. balthica ( = R. peregra = R. ovata) (6/7) and R. auricularia (1/7). Based on the amplification of the D2 domain of the 28S rDNA, the cercariae were shown to belong to two different haplotypes of Trichobilharzia franki. CONCLUSIONS: This is the first record in Belgium of T. franki and associated skin condition. [less ▲]

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See detailT2-weighted MRI signal intensity as a predictor of hormonal and tumoral responses to somatostatin receptor ligands in acromegaly: a perspective.
Potorac, Iulia ULg; Beckers, Albert ULg; BONNEVILLE, Jean-François ULg

in Pituitary (2017), 20(1), 116-120

T2-weighted MRI signal intensity of GH-secreting pituitary adenomas is gaining recognition as a marker of disease characteristics and may be a predictor of response to treatment of acromegaly. Adenomas ... [more ▼]

T2-weighted MRI signal intensity of GH-secreting pituitary adenomas is gaining recognition as a marker of disease characteristics and may be a predictor of response to treatment of acromegaly. Adenomas that are T2-hypointense are more common, are smaller and are less likely to invade the cavernous sinus compared to the T2-iso and hyperintense tumors. T2-hypointense tumors are also accompanied by higher IGF1 values at baseline. When presurgical somatostatin receptor ligand (SRL) therapy is administered, T2-hypointense adenomas have better hormonal responses and have greater tumor shrinkage. Adjuvant SRL therapy of patients with T2-hypointense tumors that are uncured by surgery is also associated with a better hormonal response. We review the studies that have dealt with the T2-weighted signal intensity of GH-secreting pituitary tumors and elaborate on the details and nuances of this promising avenue of research. [less ▲]

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See detailFoam fractionation as a tool to study the air-water interfacestructure-function relationship of wheat gluten hydrolysates
Wouters, Arno G.B.; Rombouts, Ine; Schoebrechts, Nele et al

in Colloids and Surfaces B : Biointerfaces (2017), 151

Enzymatic hydrolysis of wheat gluten protein improves its solubility and produces hydrolysates withfoaming properties which may find applications in food products. First, we here investigated whetherfoam ... [more ▼]

Enzymatic hydrolysis of wheat gluten protein improves its solubility and produces hydrolysates withfoaming properties which may find applications in food products. First, we here investigated whetherfoam-liquid fractionation can concentrate wheat gluten peptides with foaming properties. Foam andliquid fractions had high and very low foam stability (FS), respectively. In addition, foam fractions wereable to decrease surface tension more pronouncedly than un-fractionated samples and liquid fractions,suggesting they are able to arrange themselves more efficiently at an interface. As a second objective,foam fractionation served as a tool to study the structural properties of the peptides, causing thesedifferences in air-water interfacial behavior. Zeta potential and surface hydrophobicity measurements didnot fully explain these differences but suggested that hydrophobic interactions at the air-water interfaceare more important than electrostatic interactions. RP-HPLC showed a large overlap between foam andliquid fractions. However, a small fraction of very hydrophobic peptides with relatively high averagemolecular mass was clearly enriched in the foam fraction. These peptides were also more concentratedin un-fractionated DH 2 hydrolysates, which had high FS, than in DH 6 hydrolysates, which had low FS.These peptides most likely play a key role in stabilizing the air-water interface. [less ▲]

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See detailRIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.
Fettweis, Grégory ULg; Di Valentin, Emmanuel ULg; L'homme, Laurent et al

in Biochimica et Biophysica Acta (2017)

Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and ... [more ▼]

Glioblastomas are the deadliest type of brain cancer and are frequently associated with poor prognosis and a high degree of recurrence despite removal by surgical resection and treatment by chemo- and radio-therapy. Photodynamic therapy (PDT) is a treatment well known to induce mainly necrotic and apoptotic cell death in solid tumors. 5-Aminolevulinic acid (5-ALA)-based PDT was recently shown to sensitize human glioblastoma cells (LN-18) to a RIP3 (Receptor Interacting Protein 3)-dependent cell death which is counter-acted by activation of autophagy. These promising results led us to investigate the pathways involved in cell death and survival mechanisms occurring in glioblastoma following PDT. In the present study, we describe a new TSC2 (Tuberous Sclerosis 2)-dependent survival pathway implicating MK2 (MAPKAPK2) kinase and 14-3-3 proteins which conducts to the activation of a pro-survival autophagy. Moreover, we characterized a new RIP3/TSC2 complex where RIP3 is suggested to promote cell death by targeting TSC2-dependent survival pathway. These results highlight (i) a new role of TSC2 to protect glioblastoma against PDT-induced cell death and (ii) TSC2 and 14-3-3 as new RIP3 partners. [less ▲]

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See detailOptimized approach to retrieve information on atmospheric carbonyl sulfide (OCS) above the Jungfraujoch station and change in its abundance since 1995
Lejeune, Bernard ULg; Mahieu, Emmanuel ULg; Vollmer, M. K. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2017), 186

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss ... [more ▼]

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss Alps. More than 200 lines of the nu3 fundamental band of OCS have been systematically evaluated and we selected 4 microwindows on the basis of objective criteria minimizing the effect of interferences, mainly by solar features, carbon dioxide and water vapor absorption lines, while maximizing the information content. Implementation of this new retrieval strategy provided an extended time series of the OCS abundance spanning the 1995-2015 time period, for the study of the long-term trend and seasonal variation of OCS in the free troposphere and stratosphere. Three distinct periods characterize the evolution of the tropospheric partial columns: a first decreasing period (1995-2002), an intermediate increasing period (2002-2008), and the more recent period (2008-2015) which shows no significant trend. Our FTIR tropospheric and stratospheric time series are compared with new in situ gas chromatography mass spectrometry (GCMS) measurements performed by Empa (Laboratory for Air Pollution/Environmental Technology) at the Jungfraujoch since 2008, and with space-borne solar occultation observations by the ACE-FTS instrument on-board the SCISAT satellite, respectively, and they show good agreement. The OCS signal recorded above Jungfraujoch appears to be closely related to anthropogenic sulfur emissions. [less ▲]

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See detailPolyurethane coatings in 20th century outdoor painted sculptures. Part II: Comparative study of four systems by means of Py-GC/MS
Defeyt, Catherine ULg; Schilling, Michael; Langenbacher, Julia et al

in Heritage Science (2017), 5(15),

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to ... [more ▼]

Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of industrial paints, they are currently recognized as the most appropriate option to coat sculptures intended for an outdoor setting. However, the PU class includes various systems, such as two package solvent-borne, two package water-borne, one package water-borne and fluoropolymer polyurethanes, which possess very different properties. 115 reference samples of PU coatings were investigated by means of Py-GC/MS, in order to outline the differences and the similarities existing, in terms of composition, between the major PU systems used for creating as well as for conserving modern painted outdoor sculptures. The Py- GC/MS study of an extended number of reference samples showed that the composition of equivalent PU systems strongly varies depending on the product line and the manufacturer. Furthermore the comparison of all the produced pyrograms allowed defining characteristic marker compounds helpful to discriminate specific PU paint systems. [less ▲]

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See detailRap, antiracisme et identités locales en région liégeoise
Martiniello, Marco ULg

in Hommes et Migrations (2017), n°1317-1318

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See detailHigh-resolution regional modelling of natural and anthropogenic radiocarbon in the Mediterranean Sea
Ayache, M.; Dutay, J.-C.; Mouchet, Anne ULg et al

in Biogeosciences (2017), 14(5), 1197-1213

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See detailA test field for Gaia. Radial velocity catalogue of stars in the South Ecliptic Pole
Frémat, Y.; Altmann, M.; Pancino, E. et al

in Astronomy and Astrophysics (2017), 597

Context. Gaia is a space mission that is currently measuring the five astrometric parameters, as well as spectrophotometry of at least 1 billion stars to G = 20.7 mag with unprecedented precision. The ... [more ▼]

Context. Gaia is a space mission that is currently measuring the five astrometric parameters, as well as spectrophotometry of at least 1 billion stars to G = 20.7 mag with unprecedented precision. The sixth parameter in phase space (i.e., radial velocity) is also measured thanks to medium-resolution spectroscopy that is being obtained for the 150 million brightest stars. During the commissioning phase, two fields, one around each ecliptic pole, have been repeatedly observed to assess and to improve the overall satellite performances, as well as the associated reduction and analysis software. A ground-based photometric and spectroscopic survey was therefore initiated in 2007, and is still running to gather as much information as possible about the stars in these fields. This work is of particular interest to the validation of the radial velocity spectrometer outputs. <BR /> Aims: The paper presents the radial velocity measurements performed for the Southern targets in the 12-17 R magnitude range on high- to mid-resolution spectra obtained with the GIRAFFE and UVES spectrographs. <BR /> Methods: Comparison of the South Ecliptic Pole (SEP) GIRAFFE data to spectroscopic templates observed with the HERMES (Mercator in La Palma, Spain) spectrograph enabled a first coarse characterisation of the 747 SEP targets. Radial velocities were then obtained by comparing the results of three different methods. <BR /> Results: In this paper, we present an initial overview of the targets to be found in the 1 sq. deg SEP region that was observed repeatedly by Gaia ever since its commissioning. In our representative sample, we identified one galaxy, six LMC S-stars, nine candidate chromospherically active stars, and confirmed the status of 18 LMC Carbon stars. A careful study of the 3471 epoch radial velocity measurements led us to identify 145 RV constant stars with radial velocities varying by less than 1 km s[SUP]-1[/SUP]. Seventy-eight stars show significant RV scatter, while nine stars show a composite spectrum. As expected, the distribution of the RVs exhibits two main peaks that correspond to Galactic and LMC stars. By combining [Fe/H] and log g estimates, and RV determinations, we identified 203 members of the LMC, while 51 more stars are candidate members. <BR /> Conclusions: This is the first systematic spectroscopic characterisation of faint stars located in the SEP field. During the coming years, we plan to continue our survey and gather additional high- and mid-resolution data to better constrain our knowledge on key reference targets for Gaia. Tables 1-3, 5, 7, and 8 are only available at the CDS via anonym- ous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (<A href="http://130.79.128.5">http://130.79.128.5</A>) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/597/A10">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/597/A10</A>Based on data taken with the VLT-UT2 of the European Southern Observatory, programmes 084.D-0427(A), 086.D-0295(A), and 088.D-0305(A).Based on data obtained from the ESO Science Archive Facility under request number 84886.Based on data obtained with the HERMES spectrograph, installed at the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias and supported by the Fund for Scientific Research of Flanders (FWO), Belgium, the Research Council of KU Leuven, Belgium, the Fonds National de la Recherche Scientifique (F.R.S.-FNRS), Belgium, the Royal Observatory of Belgium, the Observatoire de Genève, Switzerland and the Thüringer Landessternwarte Tautenburg, Germany. [less ▲]

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See detailContribution of past and future self-defining event networks to personal identity
Demblon, Julie; D'Argembeau, Arnaud ULg

in Memory (2017), 25

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See detailAssessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride
Gerardy, Romaric ULg; Winter, Marc; Vizza, Alessandra et al

in Reaction Chemistry and Engineering (2017)

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both ... [more ▼]

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both inter- and intramolecular strategies imply the telescoping of multiple processing steps and the generation of unstable diazo species under continuous-flow conditions. The intermolecular strategy relies on an unprecedented continuous-flow Rh-catalyzed intermolecular C–H carbene insertion, providing enriched threo-N-Boc methylphenidate in 38% or 19% isolated yield according to sequential or fully telescoped processes, respectively. Quantitative Boc-deprotection is carried out off-line. The intramolecular strategy relies on a continuous-flow thermal intramolecular C–H carbene insertion, providing enriched threo-methylphenidate hydrochloride in 70% isolated yield. A continuous-flow photochemical alternative is also presented. The critical step of the most promising intramolecular strategy is implemented on the mesoscale in a pilot-scale continuous-flow reactor. [less ▲]

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See detailABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.
Canaani, Jonathan; Savani, Bipin N.; Labopin, Myriam et al

in American Journal of Hematology (2017)

ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an ... [more ▼]

ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibility affects outcome in MMURD transplantation for acute myeloid leukemia (AML) patients is unknown. We evaluated 1,013 AML patients who underwent MMURD transplantation between 2005 and 2014. Engraftment rates were comparable between ABO matched and mismatched patients, as were relapse incidence [34%; 95% confidence interval (CI), 28-39; for ABO matched vs. 36%; 95% CI, 32-40; for ABO mismatched; P = .32], and nonrelapse mortality (28%; 95% CI, 23-33; for ABO matched vs. 25%; 95% CI, 21-29; for ABO mismatched; P = .2). Three year survival was 40% for ABO matched and 43% for ABO mismatched patients (P = .35), Leukemia free survival rates were also comparable between groups (37%; 95% CI, 32-43; for ABO matched vs. 38%; 95% CI, 33-42; for ABO mismatched; P = .87). Incidence of grade II-IV acute graft versus host disease was marginally lower in patients with major ABO mismatching (Hazard ratio of 0.7, 95% CI, 0.5-1; P = .049]. ABO incompatibility probably has no significant clinical implications in MMURD transplantation. [less ▲]

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See detailCaryl Phillips’s The Lost Child: A Story of Loss and Connection
Ledent, Bénédicte ULg; O'Callaghan, Evelyn

in Ariel : A Review of International English Literature (2017)

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See detailExperimental validation of footprint models for eddy covariance CO2 flux measurements above grassland by means of natural and artificial tracers
Arriga, Nicola; Rannik, Üllar; Aubinet, Marc ULg et al

in Agricultural and Forest Meteorology (2017), 242

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See detailThe Clinical Use of Stress Echocardiography in Non-Ischaemic Heart Disease: Recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography
Lancellotti, Patrizio ULg; Pellika, PA; Budts, W et al

in Journal of the American Society of Echocardiography (2017)

A unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of ... [more ▼]

A unique and highly versatile technique, stress echocardiography (SE) is increasingly recognized for its utility in the evaluation of non-ischaemic heart disease. SE allows for simultaneous assessment of myocardial function and haemodynamics under physiological or pharmacological conditions. Due to its diagnostic and prognostic value, SE has become widely implemented to assess various conditions other than ischaemic heart disease. It has thus become essential to establish guidance for its applications and performance in the area of non-ischaemic heart disease. This paper summarizes these recommendations. [less ▲]

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See detailThe right dorsal premotor mosaic: organization, functions, and connectivity
Genon, Sarah ULg; Li, Hai; Fan, Lingzhong et al

in Cerebral Cortex (2017), 27(3), 2095-2110

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a ... [more ▼]

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our CBP results to parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography,. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into five distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found (i) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory (ii) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and (iii) a caudal subregion closely integrated with the motor system. Additionally, we found (iv) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and (v) a ventral subregion, whose functional profile fits the concept of an eye-movement related field. In conclusion, right PMd may be considered as a functional mosaic formed by five subregions. [less ▲]

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See detailLearning from Incidents and Incident Reporting: Safety Governance at a Belgian Nuclear Research Center
Rossignol, Nicolas ULg; Van Oudheusden, Michiel ULg

in Science, Technology & Human Values (2017), 42

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews ... [more ▼]

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews and focus groups with personnel, it illustrates how REX enacts a safety governmentality centered on identifying incident causes and culprits. As this governmentality mode obscures the epistemic and political character of incidents, it closes down important opportunities for collective learning about safety and safety governance. It is argued that joint reflection about incidents and resistances towards incident reporting serve as fruitful starting points for a more reflexive safety governance that makes explicit how decisions are made in high-risk contexts. Social scientists can enhance governance of this kind by pointing to different perceptions and evaluations of incidents and by insisting that contending interpretations are confronted and accounted for. [less ▲]

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See detailFactors controlling spatial and temporal patterns of multiple pesticide compounds in groundwater (Hesbaye chalk aquifer, Belgium)
Hakoun, Vivien; Orban, Philippe ULg; Dassargues, Alain ULg et al

in Environmental Pollution (2017)

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To ... [more ▼]

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To uncover which factors govern pesticide compound concentrations in a chalk aquifer, we develop a methodology based on time series analyses, uni- and multivariate statistics accounting for concentrations below detection limits. The methodology is applied to long records (1996–2013) of a restricted compound (bentazone), three banned compounds (atrazine, diuron and simazine) and two metabolites (deethylatrazine (DEA) and 2,6–dichlorobenzamide (BAM)) sampled in the Hesbaye chalk aquifer in Belgium. In the confined area, all compounds had non-detects fractions >80%. By contrast, maximum concentrations exceeded EU’s drinking-water standard (100 ngL-1) in the unconfined area. This contrast confirms that recent recharge and polluted water did not reach the confined area, yet. Multivariate analyses based on variables representative of the hydrogeological setting revealed higher diuron and simazine concentrations in the southeast of the unconfined area, where urban activities dominate land use and where the aquifer lacks protection from a less permeable layer of hardened chalk. At individual sites, positive correlations (up to τ =0,48 for bentazone) between pesticide compound concentrations and multi-annual groundwater level fluctuations confirm occurrences of remobilization. A downward temporal trend of atrazine concentrations likely reflects decreasing use of this compound over the last 28 years. However, the lack of a break in concentrations time series and maximum concentrations of atrazine, simazine, DEA and BAM exceeding EU’s standard post-ban years provide evidence of persistence. Contrasting upward trends in bentazone concentrations show that a time lag is required for restriction measures to be efficient. These results shed light on factors governing pesticide compound concentrations in chalk aquifers. The developed methodology is not restricted to chalk aquifers, it could be transposed to study other pollutants with concentrations below detection limits. Several factors govern pesticide compounds concentrations in the chalk: hydrogeological setting, land use, groundwater level fluctuations and persistence. [less ▲]

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See detailNovel genetic loci associated with hippocampal volume.
Hibar, Derrek P.; Adams, Hieab H. H.; Jahanshad, Neda et al

in Nature Communications (2017), 8

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are ... [more ▼]

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness. [less ▲]

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See detailAttenuating Effect of Zinc and Vitamin E on the Intestinal Oxidative Stress Induced by Silver Nanoparticles in Broiler Chickens.
Song, Zhigang; Lv, Jiadong; Sheikhahmadi, Ardashir et al

in Biological Trace Element Research (2017)

Silver nanoparticles (AgNPs) have been increasingly used as antimicrobial and disinfectant. However, intestinal model studies have shown that AgNPs induce oxidative stress. Hence, this study aims to ... [more ▼]

Silver nanoparticles (AgNPs) have been increasingly used as antimicrobial and disinfectant. However, intestinal model studies have shown that AgNPs induce oxidative stress. Hence, this study aims to investigate the effects of dietary supplemental zinc (Zn) and vitamin E (VE; alpha-tocopherol acetate) on attenuating AgNP-induced intestinal oxidative stress in broiler chickens. The chickens were divided into two groups as follows: (1) control group fed with a corn-soybean meal basal diet and (2) nano group, received drinking water containing 1000 mg/kg AgNPs. All the nano-exposed birds were divided into six dietary treatment groups, namely, the basal diets supplemented with (1) 60 mg/kg Zn as ZnSO4, (2) 120 mg/kg Zn, (3) 100 mg/kg VE, (4) 200 mg/kg VE, (5) 60 mg/kg Zn and 100 mg/kg VE, and (6) 120 mg/kg Zn and 200 mg/kg VE. Results showed that the AgNPs significantly reduced the body weights of the broilers after 42 days of oral administration of AgNPs (P < 0.05), and this effect was not alleviated by any of the dietary treatments. The activity of superoxide dismutase (CuZn-SOD) increased in all the AgNP-treated birds (P < 0.05); however, CuZn-SOD did not increase in birds fed with basal diet supplemented with 200 mg/kg VE. In this treatment, the VE exerted an antioxidant effect to prevent the activation of the CuZn-SOD enzyme. Furthermore, supplementing Zn increased the activities of catalase and glutathione peroxidase in the jejunal mucosa (P < 0.05), which were accompanied with increased malondialdehyde levels (P < 0.05) in the broilers. AgNP exposure resulted in a significant messenger RNA (mRNA) upregulation of toll-like receptor 4 (TLR4) and TLR2-1 in the jejunal mucosa (P < 0.05). However, supplemental ZnVE did not reduce TLRs' mRNA expression, except for the diminished TLR2-1 mRNA levels in birds fed with basal diet supplemented with 120 mg/kg Zn and 200 mg/kg VE. We concluded that although dietary Zn and VE supplementation did not attenuate growth depression effect of AgNP, it however attenuates intestinal oxidative stress in AgNP-treated broiler chickens. [less ▲]

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See detailTowards a chromatographic similarity index to establish localised Quantitative Structure-Retention Relationships for retention prediction. II Use of Tanimoto similarity index in ion chromatography
Park, S. H.; Talebi, M.; Amos, R. I. J. et al

in Journal of Chromatography. A (2017)

Quantitative Structure-Retention Relationships (QSRR) are used to predict retention times of compounds based only on their chemical structures encoded by molecular descriptors. The main concern in QSRR ... [more ▼]

Quantitative Structure-Retention Relationships (QSRR) are used to predict retention times of compounds based only on their chemical structures encoded by molecular descriptors. The main concern in QSRR modelling is to build models with high predictive power, allowing reliable retention prediction for the unknown compounds across the chromatographic space. With the aim of enhancing the prediction power of the models, in this work, our previously proposed QSRR modelling approach called "federation of local models" is extended in ion chromatography to predict retention times of unknown ions, where a local model for each target ion (unknown) is created using only structurally similar ions from the dataset. A Tanimoto similarity (TS) score was utilised as a measure of structural similarity and training sets were developed by including ions that were similar to the target ion, as defined by a threshold value. The prediction of retention parameters (a- and b-values) in the linear solvent strength (LSS) model in ion chromatography, log k = a - blog[eluent], allows the prediction of retention times under all eluent concentrations. The QSRR models for a- and b-values were developed by a genetic algorithm-partial least squares method using the retention data of inorganic and small organic anions and larger organic cations (molecular mass up to 507) on four Thermo Fisher Scientific columns (AS20, AS19, AS11HC and CS17). The corresponding predicted retention times were calculated by fitting the predicted a- and b-values of the models into the LSS model equation. The predicted retention times were also plotted against the experimental values to evaluate the goodness of fit and the predictive power of the models. The application of a TS threshold of 0.6 was found to successfully produce predictive and reliable QSRR models (Qext(F2) 2 >. 0.8 and Mean Absolute Error. <. 0.1), and hence accurate retention time predictions with an average Mean Absolute Error of 0.2. min. © 2017. [less ▲]

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See detailIntegration of Gene Expression and Methylation to unravel Biological Networks in Glioblastoma Patients
Bessonov, Kyrylo ULg; Gadaleta, Francesco; Van Steen, Kristel ULg

in Genetic Epidemiology (2017)

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information ... [more ▼]

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information. In this work we describe Regression2Net, a computational approach that is able to integrate gene expression and genomic or methylome data in two steps. First, penalized regressions are used to build Expression-Expression (EEnet) and Expression-Genome or –Methylome (EMnet) networks. Second, network theory is used to highlight important communities of genes. When applying our approach Regression2Net to gene expression and methylation profiles for individuals with glioblastoma multiforme, we identified respectively 284 and 447 potentially interesting genes in relation to glioblastoma pathology. These genes showed at least one connection in the integrated networks ANDnet and XORnet derived from aforementioned EEnet and EMnet networks. Whereas the edges in ANDnet occur in both EEnet and EMnet, the edges in XORnet occur in EMnet but not in EEnet. In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response and several cancer types. Importantly, we observed significant over-representation of cancer related pathways including glioma, especially in the XORnet network, suggesting a non-ignorable role of methylation in glioblastoma multiforma. In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. [less ▲]

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See detailPerformance-Based Financing in the heath sector in low- and middle-income countries: Is there anything whereof it may be said, See, this is new?
Paul, Elisabeth ULg; Renmans, Dimitri

in International Journal of Health Planning and Management (2017)

Whereas performance‐based financing (PBF) is nowdeveloping fast in the health sector in low‐ and middle‐income countries and is presented an innovative approach—concomitantly, subject to a separate ... [more ▼]

Whereas performance‐based financing (PBF) is nowdeveloping fast in the health sector in low‐ and middle‐income countries and is presented an innovative approach—concomitantly, subject to a separate research stream—it sharesmany features of the “managing for results” (MfR) and performance‐based budgeting (PBB) currents that have existed for decades. In this paper, we first argue that PBF as currently developed in the health sector in low‐ and middle‐income countries shares many features and thus can be viewed as an avatar of MfR andmore precisely PBB. Secondly,we drawlessons fromthe literature on MfR and PBB so as to (1) better apprehend PBF conceptually and (2) avoid pitfalls and better design PBF schemes in practice. We argue that the lessons from the theoretical and empirical literature on MfR and PBB offer interesting insights to feed into a “theory of change” of PBF, enabling to analyse critical aspects and better design PBF schemes. Moreover, it is hoped that just like MfR processes have been demonstrated as having the potential to boost individual performance not only through links with financial incentives but also through acting on other sources of motivation, one can demonstrate more accurately by which mechanisms the various elements of the PBF package can help improve health sector results. [less ▲]

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See detailPhytotoxic activity and chemical composition of Cassia absus seeds and aerial parts
Zribi, Ines; Sbai, H.; Ghezal, N. et al

in Natural Product Research (2017)

The present study was conducted to assess the phytotoxic potential and the phytochemical composition of Cassia absus. Aqueous extracts caused significant reduction of root growth of Lactuca sativa. Seed ... [more ▼]

The present study was conducted to assess the phytotoxic potential and the phytochemical composition of Cassia absus. Aqueous extracts caused significant reduction of root growth of Lactuca sativa. Seed extract was more effective than aerial part extract. Successive extractions of this plant were performed using solvents with increasing polarities. The methanolic seed extract exerted strong phytotoxic effect on seedling growth, followed by petroleum ether extract of the aerial part. The phytochemical investigation showed that among the organic extracts, methanol extracts of seeds and aerial parts contained the highest amounts of total phenolics and proanthocyanidins. Seeds were rich in linoleic acid followed by palmitic acids. Palmitic, stearic and arachidic acids were the major fatty acids in aerial parts. HPLC-DAD analysis of the methanolic extracts revealed the presence of luteolin in C. absus aerial parts. [less ▲]

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See detailChemical composition of essential oils and hydrosols of three Eucalyptus species from Senegal: Eucalyptus alba Renv, Eucalyptus camaldulensis Dehnh and Eucalyptus tereticornis Hook
Barka Ndiaye, El Hadji; Talla Gueye, Momar; Ndiaye, Ibrahima et al

in American Journal of Essential Oils and Natural Products (2017), 5(1), 1-7

The leaves of three eucalyptus species Eucalyptus Alba, Eucalyptus camaldulensis and ucalyptus tereticornis were collected in Kaolack (Senegal) and were extracted by steam distillation after 3, 7, 14 and ... [more ▼]

The leaves of three eucalyptus species Eucalyptus Alba, Eucalyptus camaldulensis and ucalyptus tereticornis were collected in Kaolack (Senegal) and were extracted by steam distillation after 3, 7, 14 and 21 days of drying. The volatile components of aqueous distillates (hydrosols) were obtained by liquid–liquid extraction using n-hexane. The different extracts were analyzed by gas chromatography coupled to a flame ionization detector (GC-FID) and by gas chromatography coupled to a mass spectrometer (GC-MS). Essential oils yields obtained range from 0.3 to 1.6%. E. camaldulensis had the higher yield. Forty four compounds were characterized in E. camaldulensis essential oils. These lasts were dominated by 1.8-cineole (47.54 to 52.47%), limonene (16.5 to 19.1%), α-pinene (7.3 to 11.2%) and p-cymene (6.0 to 8.8%). Fifty compounds were identified in E. Alba oils with 1.8-cineole (36.0-38.3%) α-pinene (19.0-26.4%), limonene (5.7- 8.3%), trans-pinocarveol (3.5 -5.0%) β-pinene (1.9 to 4.6%) as major compounds. In E. tereticornis oils, fifty two compounds were identified. Their composition were dominated by p-cymene (42.49 to 48.51%) followed by 1.8-cineole (21.3- 24.5%), limonene (4.8- 5.9%) and α-pinene (1.9 to 6.7%). The analyzed hydrosols were composed by oxygenated molecules whose major part was found in oils. As essential oils, all corresponding hydrosols hade high rate of 1.8-cineole. E. alba hydrosol contains mainly 1.8-cineole (39.1%), trans-pinocarveol (19.3%), pinocarvone (6.8%). E. camaldulensis hydrosol was dominated by 1.8-cineole (52.6%), α-terpineol (6.6%), cis-p-mentha-1-(7)-8-dien-2ol (5.1%). The major compounds of E. tereticornis hydrolat were: 1.8-cineole (30.7%), α-terpineol (8.8%), trans-pinocarveol (7.6%), carvacrol (7.0%). The results showed that although 1.8-cineole was the main component of the hydrosols of all eucalyptus species, but its relative content was higher in E. camaldulensis. [less ▲]

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See detailA new, challenging benchmark for nonlinear system identification
Tiso, Paolo; Noël, Jean-Philippe ULg

in Mechanical Systems & Signal Processing (2017), 84

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by ... [more ▼]

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by challenging the community through a new benchmark structure exhibiting complex nonlinear dynamics. The proposed structure consists of two o ffset cantilevered beams connected by a highly flexible element. For increasing forcing amplitudes, the system sequentially features linear behaviour, localised nonlinearity associated with the buckling of the connecting element, and distributed nonlinearity resulting from large elastic deformations across the structure. A finite element-based code with time integration capabilities is made available at http://sem.org/TDIV-Nonlin.asp. This code permits the numerical simulation of the benchmark dynamics in response to arbitrary excitation signals. [less ▲]

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See detailPratiques phytosanitaires des producteurs de tomates du Burkina Faso et risques pour la santé et l’environnement
Son, Diakalia ULg; Somda, Irénée; Legrève, Anne et al

in Cahiers Agricultures (2017), 26(2), 6

To assess the phytosanitary practices of tomato growers in Burkina Faso, surveys were carried out in 2015 and 2016 among 316 producers in the West and North zones of the country. Ninety percent of ... [more ▼]

To assess the phytosanitary practices of tomato growers in Burkina Faso, surveys were carried out in 2015 and 2016 among 316 producers in the West and North zones of the country. Ninety percent of pesticides used by producers are purchased in local markets without guarantee of conformity or quality. Lambda-cyhalothrin of the pyrethroids family was the most used active substance. The use for tomato crop of cotton pesticides increased strongly between 2015 and 2016 (þ71%). The doses used by producers are higher than the recommended ones. More than 70% of the market gardeners do not observe any measure of adequate protection from the preparation of the mixture until the end of the treatments. The respect of preharvest interval depends mostly of the crop health status and does not follow the recommendations. Empty containers of pesticides are left in fields by 53% of the farmers. These results show that the phytosanitary practices of tomato producers are unsuitable and potentially harmful to the health of farmers and consumers and to the environment. [less ▲]

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See detailRevisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions
Ntumba Tshibalonza, Nelly; Monbaliu, Jean-Christophe ULg

in Green Chemistry (2017)

The deoxydehydration (DODH) of glycerol towards allyl alcohol was revisited under continuous-flow conditions combining a microfluidic reactor setup and a unique reactive dynamic feed solution approach ... [more ▼]

The deoxydehydration (DODH) of glycerol towards allyl alcohol was revisited under continuous-flow conditions combining a microfluidic reactor setup and a unique reactive dynamic feed solution approach. Short reaction times, high yield and excellent selectivity were achieved at high temperature and moderate pressure in the presence of formic acid, triethyl orthoformate, or a combination of both. Triethyl orthoformate appeared as a superior reagent for the DODH of glycerol, with shorter reaction times, lower reaction temperatures and more robust conditions. In-line IR spectroscopy and computations provided different perspectives on the unique reactivity of glycerol O,O,O-orthoesters. [less ▲]

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See detailUnrelated donor haemopoietic stem-cell transplantation: ATG or not?
Baron, Frédéric ULg

in The Lancet. Haematology (2017), 4(6), 252-253

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See detailComputerized adaptive testing with R: Recent updates of the package catR
Magis, David ULg; Barrada, Juan Ramon

in Journal of Statistical Software (2017), 76(1), 1-19

The purpose of this paper is to list the recent updates of the R package catR. This package allows for generating response patterns under a computerized adaptive testing (CAT) framework with underlying ... [more ▼]

The purpose of this paper is to list the recent updates of the R package catR. This package allows for generating response patterns under a computerized adaptive testing (CAT) framework with underlying item response theory (IRT) models. Among the most important updates, well-known polytomous IRT models are now supported by catR; several item selection rules have been added; and it is now possible to perform post-hoc simulations. Some functions were also rewritten or withdrawn to improve the usefulness and performances of the package. [less ▲]

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See detailObjective assessment of visual pursuit in patients with disorders of consciousness: an exploratory study.
Wannez, Sarah ULg; Hoyoux, Thomas; Langohr, Thomas et al

in Journal of Neurology (2017)

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See detailVisual sociology approaches in migration, ethnic and racial studies
Martiniello, Marco ULg

in Ethnic and Racial Studies (2017), 40:8

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See detailAn Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters
Delcourt, Cécile ULg; Gremler, Dwayne; De Zanet, Fabrice ULg et al

in Journal of Service Management (2017), 28(1), 85-106

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them ... [more ▼]

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the criticality of the encounter. Drawing on cognitive appraisal theory, this study proposes that two key competencies—employee emotional competence (EEC) and employee technical competence (ETC)—affect negative customer emotions and customer satisfaction with employee response in ECSEs. Design/methodology—This study relies on a video-based experiment that depicts a customer involved in an ECSE as a service provider delivers bad news to him. The hypothesis tests use a two-way independent analysis of covariance. Results—Both emotional and technical competencies must be displayed to improve the customer experience in an ECSE. When EEC is low, ETC does not decrease negative customer emotions or increase customer satisfaction with employee response. When EEC is high, ETC instead has a significant impact on both customer outcomes. Practical implications—Managers must train employees to develop both technical and emotional competencies. Employees who demonstrate only one type cannot temper customers’ emotions or enhance their perceptions of the employees’ response as well as can those strong in both competencies. Originality/value—Using a video-based experiment, this study examines the moderating role of EEC in the relationship between ETC and two key aspects of the customer experience in an ECSE (negative customer emotions and customer satisfaction with employee responses) following the delivery of bad news. [less ▲]

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See detailHigh-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication
Mauroy, Axel ULg; Taminiau, Bernard ULg; Nezer, Carine et al

in Archives of Virology (2017), 16(4), 1019-1023

In this study, we report the genetic diversity and nucleotide mutation rates of five representative regions of the murine norovirus genome during in vitro passages. The mutation rates were similar in ... [more ▼]

In this study, we report the genetic diversity and nucleotide mutation rates of five representative regions of the murine norovirus genome during in vitro passages. The mutation rates were similar in genomic regions encompassing partial coding sequences for non-structural (NS) 1-2, NS5, NS6, NS7 proteins within open reading frame (ORF) 1. In a region encoding a portion of the major capsid protein (VP1) within ORF2 (also including the ORF4 region) and a portion of the minor structural protein (VP2), the mutation rates were estimated to be at least one order of magnitude higher. The VP2 coding region was found to have the highest mutation rate. [less ▲]

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See detailDeforestation and timber production in Congo after implementationof sustainable management policy: A reaction to the article by J.S.Brandt, C. Nolte and A. Agrawal (Land Use Policy 52:15–22)
Karsenty, Alain; Romero, Claudia; Cerutti, Paolo Omar et al

in Land Use Policy (2017), 65

tThis viewpoint paper presents a reaction to the article by Brandt et al. (2016). It highlights the complexitiesinherent to the attribution of deforestation impacts to policy interventions when using ... [more ▼]

tThis viewpoint paper presents a reaction to the article by Brandt et al. (2016). It highlights the complexitiesinherent to the attribution of deforestation impacts to policy interventions when using remote-sensingdata. This critique argues that in the context of the Congo a suite of factors (i.e., population density inparticular) other than those considered by Brandt et al. (e.g., type of forest, distance from roads and mar-kets) play essential roles in determining the fates of forests. It also contends that care is needed whenmaking decisions regarding which units will be included in the comparison group so that contextual fac-tors and on-the-ground information are properly considered (e.g., when logging operations are inactiveor when a concession is used for ‘conservation’ purposes). Finally, it proposes that a focus on an analysisof deforestation rates for a given level of timber production might be a metric that more accurately rep-resents one aspect of the consequences of forest management, which should also consider the appraisalof trade-offs associated with a larger set of social, financial and ecological objectives. [less ▲]

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See detailAnalysis of stable model inversion methods for constrained underactuated mechanical systems
Bastos, Guaraci J.; Seifried, Robert; Bruls, Olivier ULg

in Mechanism & Machine Theory (2017), 111

Inverse dynamics methods are presented and analyzed in detail for the feedforward control of underactuated manipulators. Thereby, two different exact strategies are discussed: the standard stable ... [more ▼]

Inverse dynamics methods are presented and analyzed in detail for the feedforward control of underactuated manipulators. Thereby, two different exact strategies are discussed: the standard stable inversion method, which relies on the formulation of a two-point boundary value problem, and an alternative optimization problem formulation, which does not require any boundary conditions. This paper proves that the solution of the optimization problem converges to the solution of the boundary value problem in the limit case where the lengths of the pre- and post-actuation phases tend to infinity. It is also shown that both strategies can be directly based on the DAE form of the equations of motion, so that there is no need to explicitly derive the input-output normal form, and standard multibody modeling codes can be used. The developments are illustrated using examples of manipulators with passive and compliant joints. [less ▲]

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See detailPrevalence of coma-recovery scale-revised signs of consciousness in patients in minimally conscious state
Wannez, Sarah ULg; Gosseries, Olivia ULg; Azzolini, Deborah et al

in Neuropsychological Rehabilitation (2017)

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See detailLong-Term Care Insurance and Intra-family Moral Hazard: Fixed vs Proportional Insurance Benefits
Klimaviciute, Justina ULg

in GENEVA Risk & Insurance Review (2017)

Pauly (1990) argues that an explanation for the low long-term care (LTC) insurance demand could be intra-family moral hazard: parents might refuse to buy insurance since it reduces children’s incentives ... [more ▼]

Pauly (1990) argues that an explanation for the low long-term care (LTC) insurance demand could be intra-family moral hazard: parents might refuse to buy insurance since it reduces children’s incentives to provide care. This paper raises and explores the idea that the extent of intra-family moral hazard and non-purchase of LTC insurance might differ when insurance benefits are fixed and when they are proportional to LTC expenditures. It shows that fixed benefits limit and might even eliminate intra-family moral hazard, while the effect of proportional benefits is at best ambiguous. Consequently, non-purchase of insurance is less likely with fixed benefits. [less ▲]

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See detailPostoperative care in endoscopic sinus surgery: a critical review.
Eloy, Philippe; Andrews, Peter; POIRRIER, Anne-Lise ULg

in Current Opinion in Otolaryngology & Head & Neck Surgery (2017), 25(1), 35-42

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard ... [more ▼]

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard treatment for medically refractive disease. Postoperative care is recommended by international leaders as an important part of the patient's management. This article is a critical review and discussion focusing on postoperative care, which is based on expert opinion, clinical studies, randomized controlled trials and meta-analysis studies. RECENT FINDINGS: Postoperative care including nasal rinsing, topical corticosteroids, antibiotics and avoidance of nasal packing are unanimously considered to be the cornerstone of best practice following FESS. However, the effectiveness of in-office nasal debridement is still under debate. SUMMARY: There is a lack of consensus regarding the necessity of performing in-office nasal debridement and the majority of clinicians carry out their postoperative care according to experience and their own preference. This is often determined by the extent of surgery performed, the severity of the postoperative inflammation, as well as being dependent on the patient's discomfort, the time constraints associated with postoperative care and the costs associated with additional appointments. Ideally, nasal debridement should be performed by the operating surgeon under endoscopic control both gently and atraumatically. [less ▲]

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See detailCrossing the dividing surface of transition state theory. IV. Dynamical regularity and dimensionality reduction as as key features of reactive trajectories
Lorquet, Jean-Claude ULg

in The Journal of Chemical Physics (2017), 146

The atom-diatom interaction is studied by classical mechanics using Jacobi coordinates (R, r, θ). Reactivity criteria that go beyond the simple requirement of transition state theory (i.e., PR* > 0) are ... [more ▼]

The atom-diatom interaction is studied by classical mechanics using Jacobi coordinates (R, r, θ). Reactivity criteria that go beyond the simple requirement of transition state theory (i.e., PR* > 0) are derived in terms of specific initial conditions. Trajectories that exactly fulfill these conditions cross the conventional dividing surface used in transition state theory (i.e., the plane in configuration space passing through a saddle point of the potential energy surface and perpendicular to the reaction coordinate) only once. Furthermore, they are observed to be strikingly similar and to form a tightly-packed bundle of perfectly collimated trajectories in the two-dimensional (R, r) configuration space, although their angular motion is highly specific for each one. Particular attention is paid to symmetrical transition states (i.e., either collinear or T-shaped with C2v symmetry) for which decoupling between angular and radial coordinates is observed, as a result of selection rules that reduce to zero Coriolis couplings between modes that belong to different irreducible representations. Liapunov exponents are equal to zero and Hamilton's characteristic function is planar in that part of configuration space that is visited by reactive trajectories. Detailed consideration is given to the concept of average reactive trajectory, which starts right from the saddle point and which is shown to be free of curvature-induced Coriolis coupling. The reaction path Hamiltonian model, together with a symmetry-based separation of the angular degree of freedom, provide an appropriate framework that leads to the formulation of an effective two-dimensional Hamiltonian. The success of the adiabatic approximation in this model is due to the symmetry of the transition state, not to a separation of time scales. Adjacent trajectories, i.e., those that do not exactly fulfill the reactivity conditions have similar characteristics, but the quality of the approximation is lower. At higher energies, these characteristics persist, but to a lesser degree. Recrossings of the dividing surface then become much more frequent and the phase space volume of initial conditions that generate recrossing-free trajectories decreases. Altogether, one ends up with an additional illustration of the concept of reactive cylinder (or conduit) in phase space that reactive trajectories must follow. Reactivity is associated with dynamical regularity and dimensionality reduction, whatever the shape of the potential energy surface, no matter how strong its anharmonicity, and whatever the curvature of its reaction path. Both simplifying features persist during the entire reactive process, up to complete separation of fragments. The ergodicity assumption commonly assumed in statistical theories is inappropriate for reactive trajectories. [less ▲]

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See detailLes droits d'enregistrement
Bourgeois, Marc ULg; Douny, Raphaël ULg; Chauvin, N. et al

in Chronique de Droit à l'Usage du Notariat (2017), 65

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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailMetamemory Following Childhood Brain Injury: A Consequence of Executive Impairment
Geurten, Marie ULg; Chevignard, Mathilde; Kerrouche, Bernadette et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2017), 23(1), 67-82

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged ... [more ▼]

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged 7 to 14 years) who had sustained a moderate to severe TBI and 44 typically developing children were recruited. Children with TBI were divided into two groups according to the severity of their executive impairment. Injury severity was determined by the Glasgow Coma Scale (GCS) score on admission or by the duration of unconsciousness. All children were then tested on both their knowledge of general memory functioning and their level of memory self-awareness, respectively assessed using total number of correct responses on an adapted version of Kreutzer et al.’s metamemory interview and a self-other discrepancy score on a questionnaire evaluating everyday memory abilities. Data analyses revealed that participants with TBI who suffered impaired executive functions demonstrated less general metamemory knowledge, and underestimated the frequency of their memory problems, compared with children with TBI who had preserved executive functions and with control participants. Considering the well-established effect of metamemory knowledge on people’s spontaneous implementation of strategies, the interest and the importance of these findings on both theoretical and clinical grounds are discussed. [less ▲]

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See detailManagement of abdominal wall desmoid tumors.
DETRY, Olivier ULg

in Acta Chirurgica Belgica (2017)

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See detailGuidelines for the Detection of Babesia and Theileria Parasites.
Lempereur, Laetitia ULg; Beck, Relja; Fonseca, Isabel et al

in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2017), 17(1), 51-65

The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They ... [more ▼]

The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They include protozoan parasites that infect erythrocytes of a variety of vertebrate hosts, including domestic and wild animals, with some Babesia spp. also infecting humans. Babesia sporozoites transmitted in the tick's saliva during the bloodmeal directly infect erythrocytes, where they asexually multiply to produce pear-shaped merozoites in the process of merogony; whereas a pre-erythrocytic schizogonic life stage in leukocytes is found in Theileria and precedes merogony in the erythrocytes. The wide spectrum of Babesia and Theileria species and their dissimilar characteristics with relation to disease severity, transmission, epidemiology, and drug susceptibility stress the importance of accurate detection of babesiosis and theileriosis and their causative agents. These guidelines review the main methods currently used for the detection of Babesia and Theileria spp. for diagnostic purposes as well as epidemiological studies involving their vertebrate hosts and arthropod vectors. Serological methods were not included once they did not indicate current infection but rather exposure. [less ▲]

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See detailShip collision analysis on Offshore Wind Turbine monopile foundations
Bela, Andreea ULg; Le Sourne, Hervé; Buldgen, Loïc ULg et al

in Marine Structures (2017), 51

An offshore wind farm covers a large maritime area and the site can be located close to traffic lanes of commercial and passenger ships, which may lead to possible collision events. The work presented in ... [more ▼]

An offshore wind farm covers a large maritime area and the site can be located close to traffic lanes of commercial and passenger ships, which may lead to possible collision events. The work presented in this paper aimed to understand both the crushing behavior and the nacelle dynamics of a predefined monopile offshore wind turbine when impacted by a ship. Another objective was to deeply investigate the influence of various parameters like ship impact velocity and location, wind direction, soil stiffness and deformability of the striking ship. First, nonlinear numerical simulations of ship - Offshore Wind Turbine (OWT) collisions have been carried out with a rigid striking ship for a better understanding of the OWT’s structural behaviour during collision. Different configurations for the wind turbine’s structure have been used in order to highlight the modifications in behaviour induced by changing the soil conditions or the loading scenario. The resulting resistant force and internal energies have been compared as well as the tower top (nacelle) displacements and accelerations. Then, another series of simulations have been performed with a deformable ship in order to investigate the influence of the deformability of the striking ship on the OWT’s behaviour. It is worth noting that all these numerical results will further serve to fix the hypotheses for the development of a simplified tool based on analytical formulations. [less ▲]

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See detailComparison of Indium Tin Oxide and Indium Tungsten Oxide as Transparent Conductive Substrates for WO3-Based Electrochromic Devices
Maho, Anthony ULg; Nicolay, Sylvain; Manceriu, Laura ULg et al

in Journal of the Electrochemical Society (2017), 164(2), 25-31

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See detailA water retention model for compacted bentonites
Dieudonné, Anne-Catherine ULg; Della Vecchia, Gabriele; Charlier, Robert ULg

in Canadian Geotechnical Journal (2017)

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See detailSingle- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.
Baron, Frédéric ULg; Ruggeri, Annalisa; Beohou, Eric et al

in Journal of Hematology & Oncology (2017), 10(1), 128

BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of ... [more ▼]

BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of two CB units from different partially HLA-matched donors (double CBT) is frequently performed in patients who lack a sufficiently rich single CB unit. METHODS: We compared CBT outcomes in patients given single or double CBT following reduced-intensity conditioning (RIC) in a retrospective multicenter registry-based study. Inclusion criteria included adult (>/=18 years) patients, acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL), complete remission (CR) at the time of transplantation, first single (with a cryopreserved TNC >/= 2.5 x 107/kg) or double CBT between 2004 and 2014, and RIC conditioning. RESULTS: Data from 534 patients with AML (n = 408) or ALL (n = 126) receiving a first single (n = 172) or double (n = 362) CBT were included in the analyses. In univariate analysis, in comparison to patients transplanted with a single CB, double CB recipients had a similar incidence of neutrophil engraftment but a suggestion for a higher incidence of grade II-IV acute GVHD (36 versus 28%, P = 0.08). In multivariate analyses, in comparison to single CBT recipients, double CBT patients had a comparable incidence of relapse (HR = 0.9, P = 0.5) and of nonrelapse mortality (HR = 0.8, P = 0.3), as well as comparable overall (HR = 0.8, P = 0.17), leukemia-free (HR = 0.8, P = 0.2) and GVHD-free, relapse-free (HR = 1.0, P = 0.3) survival. CONCLUSIONS: These data failed to demonstrate better transplantation outcomes in adult patients receiving double CBT in comparison to those receiving single CBT with adequate TNC after RIC. [less ▲]

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See detailRetention prediction of low molecular weight anions in ion chromatography based on quantitative structure-retention relationships applied to the linear solvent strength model
Park, S. H.; Haddad, P. R.; Talebi, M. et al

in Journal of Chromatography. A (2017), 1486

Quantitative Structure-Retention Relationships (QSRRs) represent a popular technique to predict the retention times of analytes, based on molecular descriptors encoding the chemical structures of the ... [more ▼]

Quantitative Structure-Retention Relationships (QSRRs) represent a popular technique to predict the retention times of analytes, based on molecular descriptors encoding the chemical structures of the analytes. The linear solvent strength (LSS) model relating the retention factor, k to the eluent concentration (log k = a − blog [eluent]), is a well-known and accurate retention model in ion chromatography (IC). In this work, QSRRs for inorganic and small organic anions were used to predict the regression parameters a and b in the LSS model (and hence retention times) for these analytes under a wide range of eluent conditions, based solely on their chemical structures. This approach was performed on retention data of inorganic and small organic anions from the “Virtual Column” software (Thermo Fisher Scientific). These retention data were recalibrated via a “porting” methodology on three columns (AS20, AS19, and AS11HC), prior to the QSRR modeling. This provided retention data more applicable on recently produced columns which may exhibit changes of column behavior due to batch-to-batch variability. Molecular descriptors for the analytes were calculated with Dragon software using the geometry-optimized molecular structures, employing the AM1 semi-empirical method. An optimal subset of molecular descriptors was then selected using an evolutionary algorithm (EA). Finally, the QSRR models were generated by multiple linear regression (MLR). As a result, six QSRR models with good predictive performance were successfully derived for a- and b-values on three columns (R2 > 0.98 and RMSE < 0.11). External validation showed the possibility of using the developed QSRR models as predictive tools in IC (Qext(F3) 2 > 0.7 and RMSEP < 0.4). Moreover, it was demonstrated that the obtained QSRR models for the a- and b-values can predict the retention times for new analytes with good accuracy and predictability (R2 of 0.98, RMSE of 0.89 min, Qext(F3) 2 of 0.96 and RMSEP of 1.18 min). © 2016 Elsevier B.V. [less ▲]

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See detailHigh resolution (1 km) positive degree-day modelling of Greenland ice sheet surface mass balance, 1870–2012 using reanalysis data
Wilton, D.; Jowett, A.; Hanna, E. et al

in Journal of Glaciology (2017), 63

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature ... [more ▼]

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature parameterization as compared with a previous version and is run at 1 km rather than 5 km resolution. The improvements lead overall to higher SMB with the same forcing data. We also compare our model with results from two regional climate models (RCMs). While there is good qualitative agreement between our PDD model and the RCMs, it usually results in lower precipitation and lower runoff but approximately equivalent SMB: mean 1979–2012 SMB (± standard deviation), in Gt a−1, is 382 ± 78 in the PDD model, compared with 379 ± 101 and 425 ± 90 for the RCMs. Comparison with in situ SMB observations suggests that the RCMs may be more accurate than PDD at local level, in some areas, although the latter generally compares well. Dividing the GrIS into seven drainage basins we show that SMB has decreased sharply in all regions since 2000. Finally we show correlation between runoff close to two calving glaciers and either calving front retreat or calving flux, this being most noticeable from the mid-1990s. [less ▲]

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See detailRationalising vitamin B6 biofortification in crop plants.
Fudge, Jared; Mangel, Nathalie; Gruissem, Wilhelm et al

in Current Opinion in Biotechnology (2017), 44

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are ... [more ▼]

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are established in all kingdoms. Human vitamin B6 dietary insufficiency or genetic defects in B6 vitamer interconversion result in various neurological and inflammatory pathologies with several populations at-risk or marginal for vitamin B6 status. Three (rice, wheat and cassava) of the world's top five staple crops do not meet the recommended dietary allowance for vitamin B6, when consumed as a major proportion of the diet. In addition, controlled enhancement of the appropriate B6 vitamer in crops has the potential to confer stress resistance. Thus, crop biofortification strategies represent an opportunity to reduce the risk of deficiency in populations with limited diet diversity and quality, as well as improving stress tolerance. [less ▲]

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See detailThe Tourist on the farm: a 'muddled' image
Dubois, Charline ULg; Cawley, Mary; Schmitz, Serge ULg

in Tourism Management (2017), 59

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better ... [more ▼]

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better understanding of agritourism, based on evidence in Wallonia (Belgium) and Luxembourg. It does so by studying the image held by four groups of actors: (i) farmers who provide ‘agritourist’ experiences; (ii) promotional organisations; and tourists who both (iii) have and (iv) have not engaged in agritourism. Agritourism is a muddled concept between realities and stakeholder expectations but opportunities exist for targeting particular niche interests. [less ▲]

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See detailPreliminary JIRAM results from Juno polar observations: 1. Methodology and analysis applied to the Jovian northern polar region
Dinelli, B. M.; Fabiano, F.; Adriani, A. et al

in Geophysical Research Letters (2017), 44(10), 4625-4632

During the first orbit around Jupiter of the NASA/Juno mission, the Jovian Auroral Infrared Mapper (JIRAM) instrument observed the auroral regions with a large number of measurements. The measured spectra ... [more ▼]

During the first orbit around Jupiter of the NASA/Juno mission, the Jovian Auroral Infrared Mapper (JIRAM) instrument observed the auroral regions with a large number of measurements. The measured spectra show both the emission of the H3+ ion and of methane in the 3–4 μm spectral region. In this paper we describe the analysis method developed to retrieve temperature and column density (CD) of the H3+ ion from JIRAM spectra in the northern auroral region. The high spatial resolution of JIRAM shows an asymmetric aurora, with CD and temperature ovals not superimposed and not exactly located where models and previous observations suggested. On the main oval averaged H3+ CDs span between 1.8 × 1012 cm−2 and 2.8 × 1012 cm−2, while the retrieved temperatures show values between 800 and 950 K. JIRAM indicates a complex relationship among H3+ CDs and temperatures on the Jupiter northern aurora. ©2017. American Geophysical Union. All Rights Reserved. [less ▲]

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See detailThe diplomacy of practitioners: for an ecology of practices about the problem of the coexistence of wind farms and red kites
Melard, François ULg; Stassart, Pierre M ULg

in Environmental Education Research (2017)

Gathering information, comparing points of view, and designing actions in and about problematic situations are no longer purely academic activities. Learning about complex state of a airs is becoming an ... [more ▼]

Gathering information, comparing points of view, and designing actions in and about problematic situations are no longer purely academic activities. Learning about complex state of a airs is becoming an increasingly widely- distributed necessity and practice, including within civil society. We propose to give rst-hand information – as practitioners and members of a citizens’ wind energy co-operative in Belgium – about the problematic and highly controversial coexistence between wind farms and red kite (Milvus milvus). Will be reported the implementation of a community-based management scheme involving active, original practices of collaboration between citizens with local knowledge and skills and experts or scientists in order to produce research and intervention questions, methods, and results that are claimed to be more sustainable. The sustainability challenges are to design and set up in context a local space for collaboration and learning that departs from traditional public regulatory procedures (i.e. impact studies, public information meetings, etc.). However, the outcomes of this collaborative approach remain fragile. We shall argue in this regard that both the Transdisciplinary Environmental Research and the art of diplomacy may be central to the emergence of re exive governance within transition processes that strive to be sustainable. [less ▲]

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See detailAbondance et diversité des communautés lombriciennes dans la Réserve et Domaine de Chasse de Bombo-Lumene (Kinshasa)
Milau Empwal, Fils; Lemtiri, Aboulkacem ULg; KIFUKIETO MANZANZA, Carmel et al

in Int. J. Biol. Chem. Sci (2017)

Les vers de terre sont des espèces importantes des écosystèmes édaphiques dotées des capacités de transformer leur biotope et même parfois de créer de nouveaux habitats pour d’autres organismes. En effet ... [more ▼]

Les vers de terre sont des espèces importantes des écosystèmes édaphiques dotées des capacités de transformer leur biotope et même parfois de créer de nouveaux habitats pour d’autres organismes. En effet, ils modifient la morphologie, la structure et la composition du sol par leur action à la fois physique, chimique et biologique. Ils ont ainsi une implication intéressante dans la fertilité et le cycle des nutriments du sol. Cette étude a été effectuée dans la Réserve et Domaine de Chasse de Bombo-Lumene (RDCBL) à Kinshasa. Elle avait pour objectif d’évaluer l’effet de l’occupation du sol sur la composition et la structure des communautés lombriciennes. Dix-huit parcelles regroupées en 6 biotopes ont été échantillonnées: les forêts denses semi décidues, les galeries forestières, les recrûs forestiers, les savanes arborescentes, les savanes herbeuses, et les sols sous culture. Au total, 10 espèces de vers de terre ont été identifiées. Elles appartiennent aux deux grandes familles tropicales : celle des Acanthodrilidae et celle des Eudrilidae. Les biotopes naturels sont les plus riches en termes de richesse d’espèces comparés aux biotopes les plus anthropisés. Dans cette étude, le type d’occupation du sol affecte considérablement la diversité des vers de terre. [less ▲]

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See detailPhotosynthetic productivity and its efficiencies in ISIMIP2a biome models: benchmarking for impact assessment studies
Ito, Akihiko; Nishina, Kazuya; Reyer, Christopher P. O. et al

in Environmental Research Letters (2017), 12(8), 085001

Simulating vegetation photosynthetic productivity (or gross primary production, GPP) is a critical feature of the biome models used for impact assessments of climate change. We conducted a benchmarking of ... [more ▼]

Simulating vegetation photosynthetic productivity (or gross primary production, GPP) is a critical feature of the biome models used for impact assessments of climate change. We conducted a benchmarking of global GPP simulated by eight biome models participating in the second phase of the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP2a) with four meteorological forcing datasets (30 simulations), using independent GPP estimates and recent satellite data of solar-induced chlorophyll fluorescence as a proxy of GPP. The simulated global terrestrial GPP ranged from 98 to 141 Pg C yr −1 (1981–2000 mean); considerable inter-model and inter-data differences were found. Major features of spatial distribution and seasonal change of GPP were captured by each model, showing good agreement with the benchmarking data. All simulations showed incremental trends of annual GPP, seasonal-cycle amplitude, radiation-use efficiency, and water-use efficiency, mainly caused by the CO 2 fertilization effect. The incremental slopes were higher than those obtained by remote sensing studies, but comparable with those by recent atmospheric observation. Apparent differences were found in the relationship between GPP and incoming solar radiation, for which forcing data differed considerably. The simulated GPP trends co-varied with a vegetation structural parameter, leaf area index, at model-dependent strengths, implying the importance of constraining canopy properties. In terms of extreme events, GPP anomalies associated with a historical El Niño event and large volcanic eruption were not consistently simulated in the model experiments due to deficiencies in both forcing data and parameterized environmental responsiveness. Although the benchmarking demonstrated the overall advancement of contemporary biome models, further refinements are required, for example, for solar radiation data and vegetation canopy schemes. [less ▲]

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See detailSimultaneous analysis of nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry.
Huang, Yang; Zhang, Tingting; Zhao, Yumei et al

in Journal of Pharmaceutical & Biomedical Analysis (2017)

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ... [more ▼]

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ginseng extracts. Few analytical methods have been developed so far to simultaneously analyze these three classes of compounds with different polarities present in ginseng extracts. In the present study, a simple and efficient analytical method was successfully developed for the simultaneous separation of 17 nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry (SFC-MS). The effect of various experimental factors on the separation performance, such as the column type, temperature and backpressure, the type of modifier and additive, and the concentration of make-up solvent were systematically investigated. Under the selected conditions, the developed method was successfully applied to the quality evaluation of 14 batches of ginseng extracts from different origins. The results obtained for the different batches indicate that this method could be employed for the quality assessment of ginseng extracts. [less ▲]

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See detailInvestigation of the added mass method for seismic design of lock gates
Buldgen, Loïc ULg; Le Sourne, Hervé; Caprace, Jean-David ULg et al

in Engineering Structures (2017)

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See detailEmployee perspectives on safety citizenship behaviors and safety violations
Chmiel, Nik; Laurent, Julie ULg; Hansez, Isabelle ULg

in Safety Science (2017), 93

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two ... [more ▼]

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two types of safety violation: routine violations conceptualized as related to an individual’s available cognitive energy or ‘effort’; and situational violations, which are those provoked by the organization (Reason, 1990). Study 1 showed SCRDs predicted situational violations only, and partially mediated the relationships between Perceived Management Commitment to Safety (PMCS) and work engagement with situational violations. These findings add to those by Hansez and Chmiel (2010), showing that routine and situational violations have predictors that differ. Study 1 findings also extend research reported by Turner et al. (2005), by showing that the effect of Job Control on SCRDs was mediated by both PMCS and work engagement. In study 2, participation in discretionary safety activities (safety participation) mediated the relationship between SCRDs and situational violations. Similar to study 1 The link between SCRDs and routine violations was non-significant and, strikingly, so was the link between safety participation and routine violations. These results support the view that processes involving SCRDs and safety participation are not cognitive-energetical in nature. In addition, study 2 findings extend previous work by Neal and Griffin (2006) by showing that SCRDs and safety knowledge partially mediated relationships between safety motivation and safety participation, whereas the direct effect of safety motivation on safety participation was non-significant. The results from both studies support the view that SCRDs are important in predicting situational violations. In study 2 SCRDs were shown to partially mediate the relationship between safety motivation and selfreported participation in discretionary safety activities (Safety Participation) which, in turn, related to situational violations. Interestingly there was no significant direct link between SCRDs and situational violations. These findings support the view that the effect of SCRDs on situational violations is fully mediated by participation in discretionary safety activities. [less ▲]

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See detailAb initio study of hydrogenic effective mass impurities in Si nanowires
Peelaers, Hartwin; Durgun, Engin; Partoens, Bart et al

in Journal of Physics : Condensed Matter (2017), 29

The effect of B and P dopants on the band structure of Si nanowires is studied using electronic structure calculations based on density functional theory. At low concentrations a dispersionless band is ... [more ▼]

The effect of B and P dopants on the band structure of Si nanowires is studied using electronic structure calculations based on density functional theory. At low concentrations a dispersionless band is formed, clearly distinguishable from the valence and conduction bands. Although this band is evidently induced by the dopant impurity, it turns out to have purely Si character. These results can be rigorously analyzed in the framework of effective mass theory. In the process we resolve some common misconceptions about the physics of hydrogenic shallow impurities, which can be more clearly elucidated in the case of nanowires than would be possible for bulk Si. We also show the importance of correctly describing the effect of dielectric confinement, which is not included in traditional electronic structure calculations, by comparing the obtained results with those of G0W0 calculations. [less ▲]

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See detailLa géographie linguistique au nord du domaine d'oïl
Baiwir, Esther ULg

in Bien Dire et Bien Aprandre : Bulletin du Centre d'Etudes Médiévales et Dialectales de l'Université de Lille III (2017), 32

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See detailLooking beyond general metrics for model comparison – lessons from an international model intercomparison study
de Boer-Euser, Tanja; Bouaziz, Laurène; De Niel, Jan et al

in Hydrology and Earth System Sciences (2017), 21

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for ... [more ▼]

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for international cooperation, they do often not lead to very clear new insights regarding the relevance of the modelled processes. We hypothesise that this is partly caused by model complexity and the comparison methods used, which focus too much on a good overall performance instead of focusing on specific events. In this study, we use an approach that focuses on the evaluation of specific events and characteristics. Eight international research groups calibrated their hourly model on the Ourthe catchment in Belgium and carried out a validation in time for the Ourthe catchment and a validation in space for nested and neighbouring catchments. The same protocol was followed for each model and an ensemble of best performing parameter sets was selected. Although the models showed similar performances based on general metrics (i.e. Nash–Sutcliffe Efficiency), clear differences could be observed for specific events. The results illustrate the relevance of including a very quick flow reservoir preceding the root zone storage to model peaks during low flows and including a slow reservoir in parallel with the fast reservoir to model the recession for the Ourthe catchment. This intercomparison enhanced the understanding of the hydrological functioning of the catchment and, above all, helped to evaluate each model against a set of alternative models. [less ▲]

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See detailVulnerability evaluation of millet and sorghum cropping system to climate change and adoption of new technologies in Mali
Sissoko, Penda ULg; Aune, Jens B.; Senneväg, Gry et al

in Asian Journal of Science and Technology (2017), 8(1), 4176-4182

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi ... [more ▼]

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi-structured interviews (ISS) using questionnaires addressed to the chiefs of family farm (FAE) were used for the collection of data. The descriptive statistics and matrices were realized for the data analysis using the following softwares: EXCEL and SPSS20.The results of the surveys conducted in 2014 among 360 farms in Sahelian and Sudano-Sahelian areas, shows that agricultural producers are aware of the main factors affecting the productivity of their cropping system and food security of agricultural holdings. Rainfall variability, characterized by failure and irregularity of rains is the main constraint of cropping systems based on millet and sorghum as stated by 97% of surveyed producers, followed by soil poverty 81%, and the lack of agricultural equipment 47%. The impacts of these factors at the farms level are translated by a decrease in the crops yields and on the frequency of the shortages in foodstuffs which are observed by 98% of the farms every year and more than 50% every 3 years. To reduce vulnerabilities, practices and innovations were adopted by farms as strategies. The main concern fertilizer micro dosing technics, seed soaking, improved varieties, organic and mineral fertilization, soils and water management technics, mechanical sowing, and agro forestry were adopted as strategies. [less ▲]

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See detailAuroral streamer and its role in driving wave-like pre-onset aurora
Yao, Zhonghua ULg; Pu, Z. Y.; Rae, I. J. et al

in Geoscience Letters (2017), 4(1), 8

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See detailRisks for All-Cause Mortality: Stratified by Age, Estimated Glomerular Filtration Rate and Albuminuria.
Warnock, DG; DELANAYE, Pierre ULg; Glassock, RJ

in Nephron (2017), 136(4), 292-297

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See detailPhase-change materials and rigidity
Piarristeguy, A.; Pradel, A.; Raty, Jean-Yves ULg

in MRS Bulletin (2017), 42(1), 45-49

Rigidity theory is an extraordinary tool to understand glasses. This article demonstrates how this model can help in understanding the link between structure, dynamics, and subtler properties such as ... [more ▼]

Rigidity theory is an extraordinary tool to understand glasses. This article demonstrates how this model can help in understanding the link between structure, dynamics, and subtler properties such as drift and aging, in particular, in phase-change materials (PCMs). First, a map of flexible/rigid regions in the Ge-(Sb)-Te system is drawn on the basis of atomistic structures modeled either by ab initio or reverse Monte Carlo techniques. A clear link between the flexible/rigid nature of the glass and its aging behavior is shown through resistivity drift as a function of composition measurements in amorphous GexTe100-x. In the particular case of amorphous GeTe, application of rigidity theory indicates that the average number of mechanical constraints decreases during aging, making the glass less stressed-rigid. Finally, the stability of PCMs also depends on the topology of the materials. The increasing number of constraints in GeTe when doped with C or N results in increased stability of the PCM. © 2017 Materials Research Society. [less ▲]

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See detailFrom skeletal muscle to stem cells: an innovative and minimally-invasive process for multiple species
Ceusters, Justine ULg; Lejeune, Jean-Philippe ULg; Sandersen, Charlotte ULg et al

in Scientific Reports (2017), 7(696),

Bone marrow and adipose tissue represent the two most commonly exploited sources of adult mesenchymal stem cells for musculoskeletal applications. Unfortunately the sampling of bone marrow and fat tissue ... [more ▼]

Bone marrow and adipose tissue represent the two most commonly exploited sources of adult mesenchymal stem cells for musculoskeletal applications. Unfortunately the sampling of bone marrow and fat tissue is invasive and does not always lead to a sufficient number of cells. The present study describes a novel sampling method based on microbiopsy of skeletal muscle in man, pigs, dogs and horses. The process includes explant of the sample, Percoll density gradient for isolation and subsequent culture of the cells. We further characterized the cells and identified their clonogenic and immunomodulatory capacities, their immune-phenotyping behavior and their capability to differentiate into chondroblasts, osteoblasts and adipocytes. In conclusion, this report describes a novel and easy-to-use technique of skeletal muscle-derived mesenchymal stem cell harvest, culture, characterization. This technique is transposable to a multitude of different animal species. [less ▲]

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See detailL'intervention de l'assureur dans le procès pénal : la défense de ton assuré tu assumeras ?
Michiels, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1

L'article aborde l'intervention de la compagnie d'assurance dans le procès pénal. Il envisage le contenu de l'article 153 § 5 de la loi du 4 avril 2014 relative aux assurances, les possibilités de défense ... [more ▼]

L'article aborde l'intervention de la compagnie d'assurance dans le procès pénal. Il envisage le contenu de l'article 153 § 5 de la loi du 4 avril 2014 relative aux assurances, les possibilités de défense de l'assureur du prévenu face à la personne lésée et les incidences des moyens et prétentions de l'assureur sur la défense pénale de son assuré prévenu. [less ▲]

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See detailEpithelial-Mesenchymal Plasticity and Circulating Tumor Cells: Travel Companions to Metastases
Francart, Marie-Emilie ULg; Lambert, Justine ULg; Vanwynsberghe, Aline ULg et al

in Developmental Dynamics : An Official Publication of the American Association of Anatomists (2017)

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See detailTime related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.
Klaassens, Bernadet L.; Rombouts, Serge A. R. B.; Winkler, Anderson ULg et al

in Human Brain Mapping (2017), 38(1), 308-325

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the ... [more ▼]

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired per subject during this randomized, double blind, placebo-controlled, crossover study. Within-group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P < 0.05, FWE-corrected) using a non-parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self-referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects. Hum Brain Mapp 38:308-325, 2017. (c) 2016 Wiley Periodicals, Inc. [less ▲]

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See detailBrucella abortus is prevalent in both humans and animals in Bangladesh
Rahman, AKM; Saegerman, Claude ULg; Berkvens, D et al

in Zoonoses and Public Health (2017)

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See detailThe use of oxytocin to improve feeding and social skills in infants with Prader-Willi syndrome
Tauber, Maïthé; Boulanouar, Kader; Gwenaelle, Diene et al

in Pediatrics (2017), 139(2),

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults ... [more ▼]

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults. Animal data demonstrated that early treatment with OXT restores sucking after birth. Our aim is to reproduce these data in infants with PWS. METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 infants in each step) who received 4 IU of OXT either every other day, daily, or twice daily. We investigated the tolerance and the effects on feeding and social skills and changes in circulating ghrelin and brain connectivity by functional MRI. RESULTS: No adverse events were reported. No dose effect was observed. Sucking assessed by the Neonatal Oral-Motor Scale was abnormal in all infants at baseline and normalized in 88% after treatment. The scores of Neonatal Oral-Motor Scale and videofluoroscopy of swallowing significantly decreased from 16 to 9 (P < .001) and from 18 to 12.5 (P < .001), respectively. Significant improvements in Clinical Global Impression scale scores, social withdrawal behavior, and mother–infant interactions were observed. We documented a significant increase in acylated ghrelin and connectivity of the right superior orbitofrontal network that correlated with changes in sucking and behavior. CONCLUSIONS: OXT is well tolerated in infants with PWS and improves feeding and social skills. These results open perspectives for early treatment in neurodevelopment diseases with feeding problems. [less ▲]

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See detailOffensive de la Russie contre l'autorité de la jurisprudence européenne relative au droit de vote des détenus: la Cour constitutionnelle russe et le contrôle du caractère "exécutoire" d'un arrêt de la Cour européenne des droits de l'homme
Rosoux, Géraldine ULg

in Revue Trimestrielle des Droits de l'Homme (2017)

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère ... [more ▼]

L'article met en perspective l'avis de la Commission de Venise du 13 juin 2016, dans lequel est examiné le mécanisme permettant à la Cour constitutionnelle russe de se prononcer sur le caractère exécutoire d'un arrêt de la Cour européenne des droits de l'homme. Cette compétence a été exercée en ce qui concerne l'arrêt Anchugov et Gladkov c. Russie, relatif au droit de vote des détenus. [less ▲]

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