References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 1201 to 1300 of 56320     8 9 10 11 12 13 14 15 16 17 18     Apport du cathétérisme cardiaque dans le diagnostic et le traitement de la maladie coronarienne avant 40 ansMEURICE, Caroline; LEGRAND, Victor ; PIERARD, Luc in Revue Médicale de Liège (2016), 71(3), 129-136Detailed reference viewed: 40 (9 ULg) Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat modelNCHIMI LONGANG, Alain ; Courtois, Audrey ; EL HACHEMI, Mounia et alin European Radiology (2016), 26Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction ... [more ▼]Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results All of the following significantly increased with time post-induction (p < 0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. [less ▲]Detailed reference viewed: 83 (16 ULg) Immiscible iron- and silica-rich liquids in the Upper Zone of the Bushveld ComplexFischer, Lennart A.; Wang, Meng; Charlier, Bernard et alin Earth and Planetary Science Letters (2016), 443Detailed reference viewed: 21 (2 ULg) Seasonal Variation of Harbor Seal's Diet from the Wadden Sea in Relation to Prey Availabilityde la Vega, Camille; Lebreton, Benoit; Siebert, Ursula et alin PLoS ONE (2016)The Wadden Sea has an important role for marine mammals in terms of resting, nursing and foraging. Harbor seal is the most abundant marine mammal species in this area. The use of the food resources of the ... [more ▼]The Wadden Sea has an important role for marine mammals in terms of resting, nursing and foraging. Harbor seal is the most abundant marine mammal species in this area. The use of the food resources of the Wadden Sea by seals is not clear, and previous studies showed that this species can travel kilometers away from their haul-outs to forage in the North Sea. In this study, we analyzed the stable isotopes of vibrissae from 23 dead harbor seals found on the island of Sylt to investigate their diet. The predator´s carbon and nitrogen isotope compositions were compared to the compositions of different potential prey items from the Sylt-Rømø Bight and from the North Sea in order to study seasonal pattern in the diet and in the foraging location. In parallel, seasonal variation of abundance and biomass of the potential prey items from the Sylt-Rømø Bight were studied and compare to their contribution to the seal´s diet. The results revealed a change in the seal´s diet from pelagic sources in spring to a benthic based diet in summer, and an increasing use of the North Sea resources in fall and winter in accordance with the seasonal variation of the availability of prey in the Sylt-Rømø Bight. [less ▲]Detailed reference viewed: 35 (10 ULg) Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study.carlier, aurelie; brems, h.; ashbourn, j.m.a. et alin Scientific Reports (2016), 7Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during early childhood by anterolateral bowing of the tibia and spontaneous tibial fractures. Although the ... [more ▼]Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during early childhood by anterolateral bowing of the tibia and spontaneous tibial fractures. Although the exact etiology of CPT is highly debated, 40-80% of CPT patients are carriers of a mutation in the Neurofibromatosis Type 1 (NF1) gene, which can potentially result in an altered phenotype of the skeletal cells and impaired bone healing. In this study we use a computational model of bone regeneration to examine the effect of the Nf1 mutation on bone fracture healing by altering the parameter values of eight key factors which describe the aberrant cellular behaviour of Nf1 haploinsufficient and Nf1 bi-allelically inactivated cells. We show that the computational model is able to predict the formation of a hamartoma as well as a wide variety of CPT phenotypes through different combinations of altered parameter values. A sensitivity analysis by "Design of Experiments" identified the impaired endochondral ossification process and increased infiltration of fibroblastic cells as key contributors to the degree of severity of CPT. Hence, the computational model results have added credibility to the experimental hypothesis of a genetic cause (i.e. Nf1 mutation) for CPT. [less ▲]Detailed reference viewed: 16 (4 ULg) Environmental Control of Root System Biology.Rellan-Alvarez, Ruben; Lobet, Guillaume ; Dinneny, Jose R.in Annual review of plant biology (2016)The plant root system traverses one of the most complex environments on earth. Understanding how roots support plant life on land requires knowing how soil properties affect the availability of nutrients ... [more ▼]The plant root system traverses one of the most complex environments on earth. Understanding how roots support plant life on land requires knowing how soil properties affect the availability of nutrients and water and how roots manipulate the soil environment to optimize acquisition of these resources. Imaging of roots in soil allows the integrated analysis and modeling of environmental interactions occurring at micro- to macroscales. Advances in phenotyping of root systems is driving innovation in cross-platformcompatible methods for data analysis. Root systems acclimate to the environment through architectural changes that act at the root-type level as well as through tissue-specific changes that affect the metabolic needs of the root and the efficiency of nutrient uptake. A molecular understanding of the signaling mechanisms that guide local and systemic signaling is providing insight into the regulatory logic of environmental responses and has identified points where crosstalk between pathways occurs. Expected final online publication date for the Annual Review of Plant Biology Volume 67 is April 29, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. [less ▲]Detailed reference viewed: 38 (3 ULg) Bone markers during acute burn care: Relevance to clinical practice?ROUSSEAU, Anne-Françoise ; Damas, Pierre ; DELANAYE, Pierre et alin Burns : Journal of the International Society for Burn Injuries (2016)OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made ... [more ▼]OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made clear. We performed an observational study assessing the changes in serum bone markers after moderate burn. METHODS: Adults admitted in the first 24h following burn extended on >10% body surface area were included. Serum levels of collagen type 1 cross-linked C-telopeptide (CTX), tartrate-resistant acid phosphatase 5b (TRAP), type 1 procollagen N-terminal (P1NP) and bone alkaline phosphatase (b-ALP) were measured at admission and every week during the first month. Data are expressed as median [min-max]. RESULTS: Bone markers were measured in 20 patients: 18 men, 2 women (including one post-menopausal). Age was 46 [19-86] years old, burn surface area reached 15 [7-85] %. Twelve patients completed the study. All biomarkers mainly remained into normal ranges during evolution. A huge variability was observed regarding biomarkers evolution. Patient's evolution was not linear and could fluctuate from a decrease to an increase of blood concentrations. There was not necessarily a consistency between the two formation or the two resorption markers. Variations observed between two consecutive measurements were lesser than the accepted critical difference in almost one third of the cases. CONCLUSIONS: Considering available data, role and interest of bone markers in management of burn related bone disease remain unclear. [less ▲]Detailed reference viewed: 11 (1 ULg) Power System Dynamic Simulations using a Parallel Two-level Schur-complement DecompositionAristidou, Petros; Lebeau, Simon; Van Cutsem, Thierry in IEEE Transactions on Power Systems (2016), 31As the need for faster power system dynamic simulations increases, it is essential to develop new algorithms that exploit parallel computing to accelerate those simulations. This paper proposes a parallel ... [more ▼]As the need for faster power system dynamic simulations increases, it is essential to develop new algorithms that exploit parallel computing to accelerate those simulations. This paper proposes a parallel algorithm based on a two-level, Schur complement-based, domain decomposition method. The two-level partitioning provides high parallelization potential (coarse and fine-grained). In addition, due to the Schur-complement approach used to update the sub-domain interface variables, the algorithm exhibits high global convergence rate. Finally, it provides significant numerical and computational acceleration. The algorithm is implemented using the shared-memory parallel programming model, targeting inexpensive multi-core machines. Its performance is reported on a real system as well as on a large test system combining transmission and distribution networks. [less ▲]Detailed reference viewed: 195 (14 ULg) DPP-4 inhibitor plus SGLT-2 inhibitor as combination therapy for type 2 diabetes: from rationale to clinical aspects.Scheen, André in Expert Opinion on Drug Metabolism & Toxicology (2016)INTRODUCTION: Type 2 diabetes (T2D) is a complex disease with multiple defects, which generally require a combination of several pharmacological approaches to control hyperglycemia. Combining a dipeptidyl ... [more ▼]INTRODUCTION: Type 2 diabetes (T2D) is a complex disease with multiple defects, which generally require a combination of several pharmacological approaches to control hyperglycemia. Combining a dipeptidyl peptidase-4 inhibitor (DPP-4i) and a sodium-glucose cotransporter type 2 inhibitor (SGT2i) appears to be an attractive approach. AREA COVERED: An extensive literature search was performed to analyze the pharmacokinetics, pharmacodynamics and clinical experience of different gliptin-gliflozin combinations. EXPERT OPINION: There is a strong rationale for combining a DPP-4i and a SGLT2i in patients with T2D because the two drugs exert different and complementary glucose-lowering effects. Dual therapy (initial combination or stepwise approach) is more potent than either monotherapy in patients treated with diet and exercise or already treated with metformin. Combining the two pharmacological options is safe and does not induce hypoglycemia. The additional glucose-lowering effect is more marked when a gliflozin is added to a gliptin than when a gliptin is added to a gliflozin. Two fixed-dose combinations (FDCs) are already available (saxagliptin-dapagliflozin and linagliptin-empagliflozin) and others are in current development. Bioequivalence of the two compounds given as FDC tablets was demonstrated when compared with coadministration of the individual tablets. FDCs could simplify the anti-hyperglycaemic therapy and improve drug compliance. [less ▲]Detailed reference viewed: 17 (2 ULg) Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.Bay-Jensen, A. C.; Reker, D.; Kjelgaard-Petersen, C. F. et alin Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society (2016), 24(1), 9-20OBJECTIVE: To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED ... [more ▼]OBJECTIVE: To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED criteria and set it in context of the medical needs of 2015. METHODS: PubMed was used as searching machine: Time period 2014/04/01-2015/05/01, MeSH term [Biomarker] AND [Osteoarthritis], Language; English, Full text available. Reviews were excluded. Only papers describing protein based biomarkers measured in human body fluids from OA patients were included. RESULTS: Biomarkers of joint tissue turnover, cytokines, chemokines and peptide arrays were measured in different cohorts and studies. Amongst those were previously tested biomarkers such as osteocalcin, Carboxy-terminal cross-linked fragment of type II collagen (CTX-II) and cartilage oligomeric matrix protein (COMP). A majority of the biomarker were classified as I, B or B biomarkers according to the BIPED criteria. Work is continuing on testing biomarkers in OA. There is still a huge, unmet medical need to identify, test, validate and qualify novel and well-known biomarkers. A pre-requisite for this is better characterization and classification of biomarkers to their needs, which may not be reached before higher understanding of OA phenotypes has been gained. In addition, we provide some references to some recent guidelines from Food and Drug Administration (FDA) and European Medicines Agency (EMA) on qualification and usage of biomarkers for drug development and personalized medicine, which may provide value to the field. [less ▲]Detailed reference viewed: 17 (1 ULg) Interrelations de la criminologie et du droit autour de la délinquance juvénile : Je t’aime moi non plusMathys, Cécile in Revue de la Faculté de Droit de l'Université de Liège (2016), 1Detailed reference viewed: 25 (7 ULg) Impact of climatic factors on the release of E-β-caryophyllene from alginate beadsDaems, Frédéric ; Bera, François ; Lorge, Stéphanie et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(2), Description of the subject. Alginate beads that release semiochemical compounds are interesting biological control devices used to attract the natural enemies of aphids in infested crops. Little ... [more ▼]Description of the subject. Alginate beads that release semiochemical compounds are interesting biological control devices used to attract the natural enemies of aphids in infested crops. Little information, however, is available about the impact of climatic factors on the release of semiochemicals from this diffusive system. Objectives. The objective of this scoping study was to investigate the impact of temperature, relative humidity and wind speed, on the release of E-β-caryophyllene from alginate beads. Method. The impact of the three climatic factors on the release of E-β-caryophyllene from alginate beads was evaluated using a Box-Behnken experimental design and a laboratory scale volatile collection system. The influence of relative humidity on bead water content and size, with and without this semiochemical, was also investigated using a gravimetric method and an easy-to-use photographic device, respectively. Results. The results showed that an increase in temperature caused a significant increase in the E-β¬-caryophyllene release rate. Neither relative humidity nor airflow, however, had a significant effect on the release of this semiochemical when relative humidity and wind speed ranged from 33% to 75% and from 6.61 x10-4 m.s-1 to 2.05 x10-2 m.s-1, respectively. The isotherm curves obtained were characteristic of food products and biopolymer materials. The isotherm shapes were not modified by the incorporation of the semiochemical into alginate beads, and showed an important increase in water content when relative humidity values exceeded 85%. Fortunately, this water content increase did not affect bead size, which facilitates the calculation of E-β-caryophyllene release. Conclusion. The present study shows for the first time the impact of the three main climatic factors on the release of E-β-caryophyllene from alginate beads. It allows learning more about how these biological control devices operate in order to optimize future field trials. [less ▲]Detailed reference viewed: 56 (11 ULg) Light-sensitive brain pathways and agingDaneault, Véronique; Dumont, Marie; Massé, Eric et alin Journal of Physiological Anthropology (2016), 35(9), Detailed reference viewed: 17 (1 ULg) Forced Convective Drying of Wastewater Sludge with Presentation of Exergy Analysis of the DryerBennamoun, Lyes; Fraikin, Laurent ; Li, Jie et alin Chemical Engineering Communications (2016), 203The main objective is studying the fundamental aspect, by the mean of the drying kinetics, the application of forced convective drying of wastewater sludge with determination of the optimum drying ... [more ▼]The main objective is studying the fundamental aspect, by the mean of the drying kinetics, the application of forced convective drying of wastewater sludge with determination of the optimum drying conditions. The drying system is composed of two units; small samples of 2.5 g are dried in the first unit and bed of sludge weighting 250 g is dried the second unit. The experiments are performed under air temperatures varying between 80°C and 200°C. The range of the air velocity and its humidity is 1- 2 m/s and 0.005- 0.05 kgwater/kgdry air, respectively. The experiments are performed for two different sludges; activated sludge (AS) and thermalized and digested sludge (TDS). Usually, three main drying phases are observed during drying of bed of sludge. These phases are reduced to only two for small samples. Determination of the influent parameters shows that temperature of the drying air and sludge origin can profoundly influence the drying kinetic of the sludge. The exergy analysis of the two units of the drying system allows selecting 140 °C, 2 m/s, 0.05 kgwater/kgdry air as optimum drying condition with an exergy efficiency reaching 90\%. [less ▲]Detailed reference viewed: 31 (2 ULg) A qPCR aptasensor for sensitive detection of aflatoxin M1Guo, Xiaodong; Wen, Fang; Zheng, Nan et alin Analytical and Bioanalytical Chemistry (2016), 408(20), 55775584Aflatoxin M1 (AFM1), one of the most toxic mycotoxins, imposes serious health hazards. AFM1 had previously been classiﬁed as a group 2B carcinogen1 and has been classified as a group 1 carcinogen by the ... [more ▼]Aflatoxin M1 (AFM1), one of the most toxic mycotoxins, imposes serious health hazards. AFM1 had previously been classiﬁed as a group 2B carcinogen1 and has been classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO).2 Determination of AFM1 thus plays an important role for quality control of food safety. In this work, a sensitive and reliable aptasensor was developed for the detection of AFM1. The immobilization of aptamer through a strong interaction with biotin–streptavidin was used as a molecular recognition element, and its complementary ssDNA was employed as the template for a real-time quantitative polymerase chain reaction (RT-qPCR) amplification. Under optimized assay conditions, a linear relationship (ranging from 1.0×10-4 to 1.0 µg L-1) was achieved with a limit of detection (LOD) down to 0.03 ng L-1. In addition, the aptasensor developed here exhibits high selectivity for AFM1 over other mycotoxins and small effects from cross-reaction with structural analogs. The method proposed here has been successfully applied to quantitative determination of AFM1 in infant rice cereal and infant milk powder samples. Results demonstrated that the current approach is potentially useful for food safety analysis, and it could be extended to a large number of targets. [less ▲]Detailed reference viewed: 82 (8 ULg) Une présentation rare de craniosténose associée à un crâne lacunaireVaessen, françois; Thimmesch, Mathieu; BORN, Jacques et alin Revue Médicale de Liège (2016), 71(3), 120-123A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its ... [more ▼]A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its physiopathology remains up to now poorly understood; it is mostly associated with neural tube defects. The association of a lacunar skull with a craniosynostosis has rarely been described in the literature. The case of a 9-month-old patient presenting a multisutural craniosynostosis with a lacunar skull is reported in this article. The surgical treatment allowed to remodel the skull and to hope for a spontaneous regression of the lacunae. [less ▲]Detailed reference viewed: 32 (4 ULg) Two 3D thermomechanical numerical models of friction stir welding processes with a trigonal pinBussetta, Philippe; Feulvarch, Eric; Tongne, Amèvi et alin Numerical Heat Transfer : Part A. Applications (2016)Detailed reference viewed: 15 (6 ULg) First-Principles Study of the Thermoelectric Properties of SrRuO3Miao, Naihua; Xu, Bin ; Bristowe, Nicholas et alin Journal of Physical Chemistry (2016), 120Detailed reference viewed: 62 (6 ULg) Analytical and clinical evaluation of the new Fujirebio Lumipulse G non-competitive assay for 25(OH)-vitamin D and three immunoassays for 25(OH)D in healthy subjects, osteoporotic patients, third trimester pregnant women, healthy African subjects, hemodialyzed and intensive care patientsCAVALIER, Etienne ; LUKAS, Pierre ; BEKAERT, Anne-Catherine et alin Clinical Chemistry & Laboratory Medicine (2016)Detailed reference viewed: 45 (14 ULg) Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out miceScoumanne, Ariane; Molina Ortiz, Patricia ; Monteyne, Daniel et alin Advances in Biological Regulation (2016), 62Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases family which phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5 ... [more ▼]Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases family which phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate. Although expression and function of the two other family members ITPKA and ITPKB are rather well characterized, similar information is lacking for ITPKC. Here, we first defined the expression of Itpkc mRNA and protein in mouse tissues and cells using in situ hybridization and new antibodies. Surprisingly, we found that cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures. Given this surprising expression, we then analyzed ITPKC function in multiciliated tracheal epithelial cells and sperm cells using our Itpkc knock-out mouse model. Unfortunately, no significant difference was observed between control and mutant mice for any of the parameters tested, leaving the exact in vivo function of this third Ins(1,4,5)P3 3-kinase still open. [less ▲]Detailed reference viewed: 46 (5 ULg) Les normes techniques peuvent être obligatoiresZians, Audrey in Revue Trimestrielle de Droit Européen (2016), 1(janvier-mars), 185-186Une norme technique nationale peut être rendue obligatoire par le législateur d'un Etat membre (CJUE 15 octobre 2015, aff. C-251/14, Balázs, EU:C:2015:687)Detailed reference viewed: 7 (2 ULg) An endogenous gibbon ape leukemia virus (GALV) identified in a rodent (Melomys sp.) from IndonesiaNiccolo, Alfano; Michaux, Johan ; Fabre, pierre-Henri et alin Journal of Virology (2016), sous presseABSTRACT Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated from a cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or more ... [more ▼]ABSTRACT Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated from a cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or more intermediate as yet unknown hosts. A highly similar virus to GALV has been identified in an Australian rodent (Melomys burtoni) after extensive screening of Australian wildlife. GALV-like viruses have also been discovered in several Southeast Asian species although screening has not been extensive and viruses discovered to date are only distantly related to GALV. We therefore screened 26 Southeast Asian rodent species for KoRV- and GALV-like sequences, using hybridization capture and high-throughput sequencing, in the attempt to identify potential GALV and KoRV hosts. Only one species, an undescribed species of Melomys from Indonesia, was positive yielding an endogenous provirus very closely related to a strain of GALV. The sequence of the critical receptor domain for GALV infection in the Indonesian Melomys sp. was consistent with the susceptibility of the species to GALV infection. The discovery of a GALV in a second Melomys species provides further evidence that Melomys may play a role in the spread of GALV-like viruses, especially since the genus is found in Indonesia, Papua New Guinea and Australia, connecting the home ranges of koalas and gibbons. IMPORTANCE The gibbon ape leukemia virus (GALV) and the koala retrovirus (KoRV) are very closely related, yet their hosts are neither closely related nor overlap geographically. Direct cross-species infection between koalas and gibbons is unlikely. Therfore, GALV and KoRV may have arisen via a cross-species transfer from an intermediate host that overlaps in range with both gibbons and koalas. Using hybridization capture and high-throughput sequencing, we have screened a wide range of rodent candidate hosts from Southeast Asia for KoRV- and GALV-like sequences. Only a Melomys species from Indonesia was positive for GALV. We report the genome sequence of this newly identified GALV, the critical domain for infection of its potential cellular receptor and its phylogenetic relationships with the other previously characterized GALVs. We hypothesize that the genus Melomys may have played a key role in cross-species transmission to other taxa. [less ▲]Detailed reference viewed: 63 (4 ULg) Transatlantic Editorial: A Comparison Between European and North American Guidelines on Myocardial Revascularization.Kolh, Philippe ; Kurlansky, Paul; Cremer, Jochen et alin Annals of Thoracic Surgery (2016), 101(6), 2031-44Detailed reference viewed: 8 (0 ULg) Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxibHochberg, M. C.; Martel-Pelletier, J.; Monfort, J. et alin Ann Rheum Dis (2016), 75(1), 37-44OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind ... [more ▼]OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES) conducted in France, Germany, Poland and Spain evaluating treatment with CS+GH versus celecoxib in 606 patients with Kellgren and Lawrence grades 2-3 knee osteoarthritis and moderate-to-severe pain (Western Ontario and McMaster osteoarthritis index (WOMAC) score >/=301; 0-500 scale). Patients were randomised to receive 400 mg CS plus 500 mg GH three times a day or 200 mg celecoxib every day for 6 months. The primary outcome was the mean decrease in WOMAC pain from baseline to 6 months. Secondary outcomes included WOMAC function and stiffness, visual analogue scale for pain, presence of joint swelling/effusion, rescue medication consumption, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria and EuroQoL-5D. RESULTS: The adjusted mean change (95% CI) in WOMAC pain was -185.7 (-200.3 to -171.1) (50.1% decrease) with CS+GH and -186.8 (-201.7 to -171.9) (50.2% decrease) with celecoxib, meeting the non-inferiority margin of -40: -1.11 (-22.0 to 19.8; p=0.92). All sensitivity analyses were consistent with that result. At 6 months, 79.7% of patients in the combination group and 79.2% in the celecoxib group fulfilled OMERACT-OARSI criteria. Both groups elicited a reduction >50% in the presence of joint swelling; a similar reduction was seen for effusion. No differences were observed for the other secondary outcomes. Adverse events were low and similarly distributed between groups. CONCLUSIONS: CS+GH has comparable efficacy to celecoxib in reducing pain, stiffness, functional limitation and joint swelling/effusion after 6 months in patients with painful knee osteoarthritis, with a good safety profile. TRIAL REGISTRATION NUMBER: NCT01425853. [less ▲]Detailed reference viewed: 19 (0 ULg) Information behaviour of French-speaking speech–language therapists in Belgium: results of a questionnaire surveyDurieux, Nancy ; Pasleau, Françoise ; Piazza, Aurélie et alin Health Information and Libraries Journal (2016), 33BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study ... [more ▼]BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study was to explore Belgian French-speaking SLTs’ information behaviour and their awareness of EBP. The collected data allow one to determine how far they have embraced this approach. METHODS: The two Belgian French-speaking SLT professional associations promoted an online questionnaire survey by email. Additionally, clinical supervisors of students were asked to participate. In March 2012, 2068 emails were sent. RESULTS: The participation rate was at least 20% (n = 415). The reported information needs mainly concerned treatment or diagnosis. Most of the time, to attempt to fulfil their information needs, SLTs relied on their own resources (personal experience and libraries) and on colleagues in the workplace. When they searched on the Internet, they preferred to use a general search engine rather than a specialised bibliographic database. Barriers to obtaining scientific information are highlighted. Only 12% of the respondents had already heard about EBP. CONCLUSION: This study provides the first overview of the information behaviour of SLTs working in the French community of Belgium. Several recommendations are suggested for SLTs and librarians. [less ▲]Detailed reference viewed: 79 (30 ULg) All for a container! Return migration, transport technologies, and love affairsJedlowski, Alessandro in Transfers: Interdisciplinary Journal of Mobility Studies (2016)This paper analyzes the articulation between mobility and technology within life trajectories marked by migration, exile and the search for economic achievement. It does so by focusing on a Nigerian ... [more ▼]This paper analyzes the articulation between mobility and technology within life trajectories marked by migration, exile and the search for economic achievement. It does so by focusing on a Nigerian couple’s (attempted) itinerary of return migration from Italy to Nigeria, and on the tensions that surround the role played by a specific transport technology, the shipping container, within this process. It highlights how, throughout the itinerary that brings the container from Italy to Nigeria, its social meaning and that of the cargo stored in it become the center of a series of tense interactions, in which diverging imaginaries about transnational mobility, migration and life abroad come to the fore, and provoke radical transformations in the life of the people involved in the itinerary of the container itself. [less ▲]Detailed reference viewed: 66 (14 ULg) Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopeniaReginster, Jean-Yves ; Cooper, Cyrus; Rizzoli, René et alin Aging Clinical and Experimental Research (2016), 28(1), 47-58Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a ... [more ▼]Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities. Methods: A multidisciplinary expert working group was hosted by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, which reviewed and discussed the recent literature from a perspective of clinical experience and guideline development. Relevant parallels were drawn from the development of definition of osteoporosis as a disease and clinical assessment of pharmaceutical treatments for that indication. Results A case-finding decision tree is briefly reviewed with a discussion of recent prevalence estimations of different relevant threshold values. The selection criteria for patients in regulatory studies are discussed according to the aims of the investigation (sarcopenia prevention or treatment) and the stage of project development. The possible endpoints of such studies are reviewed and a pleais made for the establishment of a core outcome set to be used in all clinical trials of sarcopenia. Conclusions : The current lack of guidelines for the assessment of new therapeutic treatments for sarcopenia could potentially hinder the delivery of effective medicines to patients at risk. [less ▲]Detailed reference viewed: 32 (12 ULg) Edouard Poty: a bio- and bibliographyDenayer, Julien ; Aretz, Markus ; Barchy, Laurent et alin Geologica Belgica (2016), 19(1-2), 3-6Detailed reference viewed: 23 (2 ULg) Quantum Nuclear Dynamics Pumped and Probed by Ultrafast Polarization Controlled Steering of a Coherent Electronic State in LiHNikodem, Astrid ; Levine, R. D.; Remacle, Françoise in Journal of Physical Chemistry A (2016), 120(19), 3343-3352Detailed reference viewed: 18 (1 ULg) The role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study.Runhaar, J.; DEROISY, Rita ; van Middelkoop, M. et alin Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 42-48Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a ... [more ▼]Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a tailored diet and exercise program (DEP)or by oral glucosamine sulfate in women at risk for the disease, using a composite clinical and/or radiological outcome. The aim of this updated post-hoc analysis was to re-assess the results according to more precise techniques and take advantage of the 2 x 2 factorial design. Methods: A total of 407 overweight( BMI > or egal 27kg/m2) women of 50–60 years of age with no diagnosis of knee OA were randomized to: (1) noDEP + placebo(Control, N = 102), (2) DEP + placebo (DEP, N = 101), (3) glucosamine sulfate + no DEP (GS, N = 102), and (4) DEP + glucosamine sulfate (DEP + GS, N = 102) and followed for 2.5 years, with standardized postero-anterior, semiflexed (MTP) view knee radiographs at baseline and end of the study. DEP consisted of a tailored low fat and/or low caloric diet and easy to implement physical activities. Glucosamine was given as oral crystalline glucosamine sulfate 1500 mg once daily ,double-blinded vs. placebo. Incident knee OA was defined as radiographic progression of >1mm minimum joint space narrowing (mJSN)in the medial tibiofemoral compartment, as previously assessed by the visual (manual) technique and by a new semi-automated method. Logistic regression analysis was used t ocalculate the odds ratio for the effect of the interventions. Results: After 2.5 years, 11.8% of control subjects developed knee OA. This incidence was decreased with glucosamine sulfate, either alone or in combination with the DEP, but not by the DEP alone. Since there was no statistical interaction between treatments, the 2x2 factorial design allowed analysis of patients receiving glucosamine sulfate (N = 204) vs. those not receiving it (N= 203), similarly for those on the DEP (N = 203) or not (N = 204). Glucosamine sulfate significantly decreased the risk of developing knee OA: odds ratio (OR) = 0.41(95% CI: 0.20–0.85, P = 0.02) by the manual JSN assessment method and OR = 0.42 (95% CI:0.20–0.92, P =0.03) by the semi-automated technique. Conversely, there was no decrease in risk with the DEP. Conclusions: Glucosamine sulfate decreased the risk of developing radiographic knee OA over 2.5 years in overweight, middle-aged women at risk, as determined by medial mJSN progression. Conversely a tailored diet and exercise program exerted no preventive effect, possibly because of the lower than expected effect on weigh tloss. [less ▲]Detailed reference viewed: 45 (9 ULg) Plan de formation-insertion et garantie d'emploi : l'employeur qui s'engageCordier, Quentin in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), 14Detailed reference viewed: 24 (5 ULg) Production of New Cotton Interspecific Hybrids with Enhanced Fiber FinenessNacoulima, L.N.; Diouf, F.H.; Konan, N.O. et alin Journal of Agricultural Science (2016), 8(2), 46-56To improve cotton fiber fineness, the (Gossypium hirsutum L. × Gossypium longicalyx Hutch. & Lee)² allohexaploid and the [(Gossypium hirsutum L. × Gossypium thurberi To d . ) ² × G. longicalyx ... [more ▼]To improve cotton fiber fineness, the (Gossypium hirsutum L. × Gossypium longicalyx Hutch. & Lee)² allohexaploid and the [(Gossypium hirsutum L. × Gossypium thurberi To d . ) ² × G. longicalyx] allotetraploid were backcrossed to G. hirsutum to produce introgressed genetic stocks. The ribbon width (RW) of 600 swelled fibers produced by the hybrids, their parents, and their backcross progeny were analyzed for each compared genotype using an optical microscope. The RWs varied between 6.41±2.15 µm for G. longicalyx to 17.45±2.98 µm for the G. hirsutum parent cultivar C2. Fibers produced by the trispecific hybrids and their progeny were finer than the bispecific hybrid material. For the introgressed stocks, the lowest RWs were observed for the trispecific hybrid (10.79±2.14 µm) and certain backcross progenies (between 11.98±1.27 µm to 12.71±1.61 µm). The allohexaploid RW was 13.58±1.41 µm. One of its tetraploid progeny produced approximately the same value (13.94±2.48 µm). These results show that G. longicalyx is a potential genetic stock for cotton fiber fineness improvement. The genetic stocks produced are valuable materials for improve the fineness of cotton fiber. [less ▲]Detailed reference viewed: 32 (5 ULg) Nutritive value of three tropical forgae legumes and their influence on growth performance, carcass traits and organ weights of pigsKambashi Mutiaka, Bienvenu ; Kalala Bolokango, Gaetan ; Dochain, Denis et alin Tropical Animal Health and Production (2016), 48(6), 1165-1173The effects of tropical forage legumes on feed intake, growth performance and carcass traits were investigated in 16 groups of two Large White × Duroc pigs. The diets consisted of a commercial ... [more ▼]The effects of tropical forage legumes on feed intake, growth performance and carcass traits were investigated in 16 groups of two Large White × Duroc pigs. The diets consisted of a commercial corn–soybean meal diet as the basal diet and three forage-supplemented diets. Four groups of control pigs received daily 4 % of body weight of the basal diet, and 12 groups of experimental pigs were fed the basal diet at 3.2 % of body weight completed with fresh leaves of one of the three forage legumes (Psophocarpus scandens, Stylosanthes guianensis and Vigna unguiculata) ad libitum. The study lasted 90 days. The in vitro digestion and fermentation of the forage legumes were also determined. The in vitro digestible energy content of the legumes was between 0.72 and 0.77 that of the basal diet (14.4 MJ/kg dry matter (DM)). V. unguiculata was the most digestible forage legume expected for crude protein digestibility. Feeding forage legumes lowered the dry matter intake by 4.5 to 9.6 % (P< 0.05), final body weight (P= 0.013), slaughter weight, average daily gain and hot carcass weight (P< 0.05) without affecting the feed conversion ratio (FCR), dressing percentage and back fat thickness. In conclusion, using forage to feed pig could be interesting in pig smallholder productionwith limited access to concentrate, as FCR was not significantly affected. [less ▲]Detailed reference viewed: 33 (12 ULg) Nociceptive and sympathetic innervations in the abaxial part of the cranial horn of the equine medial meniscus: an immunohistochemical approachNemery, Elodie ; Gabriel, Annick ; Piret, Joëlle et alin Journal of Anatomy (2016)In athletic horses, diseases leading to lameness are of major importance due to the loss of performance and the resultant economic concerns. Although, in the hindlimb, stifle lesions are frequent due to ... [more ▼]In athletic horses, diseases leading to lameness are of major importance due to the loss of performance and the resultant economic concerns. Although, in the hindlimb, stifle lesions are frequent due to the large and complex joint, and meniscal tears have been identified as the most common soft tissue injuries in this joint, little is known about the mechanism that causes the painful sensation and thus the lameness. The aim of our study was therefore to highlight any peripheral fibres involved in meniscal nociception in five healthy anterior horns of the equine medial meniscus, which is the most common locale reported for equine meniscal injuries. Immunohistochemical stainings were performed using antibodies against Substance P in order to identify nociceptive fibres; antibodies against tyrosine hydroxylase for detecting postganglionic sympathetic fibres; and against glial fibrillary acidic proteins in order to identify Schwann cells. Fundamentally, our work highlights for the first time the presence of nociceptive and sympathetic fibres in equine menisci. They were found in the abaxial part of the anterior horn of the equine medial meniscus. This study suggests thus that when the abaxial part is injured, the meniscus itself could be the source of pain. This finding provides a better understanding of the nociceptive and sympathetic innervation of the equine meniscus which could contribute towards improving the therapeutic strategies in order to alleviate pain in cases of equine meniscal injury. [less ▲]Detailed reference viewed: 20 (11 ULg) Variable thickness scroll compressor performance analysis—Part I: Geometric and thermodynamic modelingBin, Peng; Lemort, Vincent ; Legros, Arnaud et alin Proc IMechE Part E: J Process Mechanical Engineering (2016)In order to investigate the performance of variable thickness scroll compressors, a detail mathematical modeling based on energy and mass balances is established in this two-part. In part I, the geometric ... [more ▼]In order to investigate the performance of variable thickness scroll compressors, a detail mathematical modeling based on energy and mass balances is established in this two-part. In part I, the geometric modeling and thermodynamic modeling are developed. The profile based on circle involute, high order curve, and arc is built up using the base line method. The volume of working chambers from suction to discharge is defined. Thereafter, the evolution and derivative of the working chamber volume with respect to the orbiting angle are discussed. The energy and the mass balance for working chamber are described. Suction gas heating, radial and flank leakage, heat transfer between the working fluid, scroll wraps and plates are considered in the thermodynamic modeling. The established geometric modeling and thermodynamic modeling can provide better understanding of the variable thickness scroll compressor working process. The dynamical modeling and model validation are reported in part II. [less ▲]Detailed reference viewed: 25 (0 ULg) Réparation des ouvrages en béton armé - Partie 2 : Compatibilité et performancesCourard, Luc ; Bissonnette, Benoîtin Techniques de l'Ingénieur. Analyse Chimique et Caractérisation (2016)La réparation des bétons nécessite non seulement une bonne connaissance du support à réparer, des matériaux de réparation et de l’environnement dans lequel ils vont être mis en œuvre, mais aussi une ... [more ▼]La réparation des bétons nécessite non seulement une bonne connaissance du support à réparer, des matériaux de réparation et de l’environnement dans lequel ils vont être mis en œuvre, mais aussi une compréhension des mécanismes à la base de l’adhésion. Les compatibilités dimensionnelle, électrochimique, chimique et porosimétrique (perméabilité) sont les clés de la réussite et de la durabilité de la réparation. Sur la base de l’analyse du patrimoine en béton armé et des stratégies d’intervention possible, l’accent a été placé dans la première partie sur l’étude des effets et des causes des principaux défauts de surface observés. Une fois la condition du béton en place adéquatement évaluée (Partie 1), la préparation de la surface avant réparation, sa propreté ou encore sa rugosité sont des conditions essentielles au développement de l’adhérence et de l’accrochage du produit de réparation, garantissant ainsi la durabilité de l’intervention. [less ▲]Detailed reference viewed: 30 (1 ULg) Potential contribution of progesterone receptors to the development of sexual behavior in male and female mice.Desroziers, Elodie; Brock, Olivier; Bakker, Julie in Hormones and Behavior (2016)We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in ... [more ▼]We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in adulthood, whereas prepubertal estradiol feminized this ability. Furthermore, we found that estradiol upregulates progesterone receptors (PR) during development, inducing both a male-and female-typical pattern of PR expression in the mouse hypothalamus. In the present study, we took advantage of a newly developed PR antagonist (ZK 137316) to determine whether PR contributes to either male- or female-typical sexual differentiation. Thus groups of male and female C57Bl/6j mice were treated with ZK 137316 or oil as control: males were treated neonatally (P0-P10), during the critical period for male sexual differentiation, and females were treated prepubertally (P15-P25), during the critical period for female sexual differentiation. In adulthood, mice were tested for sexual behavior. In males, some minor effects of neonatal ZK treatment on sexual behavior were observed: latencies to the first mount, intromission and ejaculation were decreased in neonatally ZK treated males; however, this effect disappeared by the second mating test. By contrast, female mice treated with ZK during the prepubertal period showed significantly less lordosis than OIL-treated females. Mate preferences were not affected in either males or females treated with ZK during development. Taken together, these results suggest a role for PR and thus perhaps progesterone in the development of lordosis behavior in female mice. By contrast, no obvious role for PR can be discerned in the development of male sexual behavior. [less ▲]Detailed reference viewed: 13 (2 ULg) High Temperature Ferromagnetism in a GdAg2 MonolayerOrmaza, M.; Fernandez, L.; Ilyn, M. et alin Nano Letters (2016), 0(0), Detailed reference viewed: 46 (3 ULg) 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).Galie, Nazzareno; Humbert, Marc; Vachiery, Jean-Luc et alin European heart journal (2016), 37(1), 67-119Detailed reference viewed: 33 (0 ULg) Recommendations for the imaging assessment of prosthetic heart valves: a report from the European Association of Cardiovascular Imaging endorsed by the Chinese Society of Echocardiography, the Inter-American Society of Echocardiography, and the Brazilian Department of Cardiovascular Imaging.Lancellotti, Patrizio ; Pibarot, Philippe; Chambers, John et alin European heart journal cardiovascular Imaging (2016)Prosthetic heart valve (PHV) dysfunction is rare but potentially life-threatening. Although often challenging, establishing the exact cause of PHV dysfunction is essential to determine the appropriate ... [more ▼]Prosthetic heart valve (PHV) dysfunction is rare but potentially life-threatening. Although often challenging, establishing the exact cause of PHV dysfunction is essential to determine the appropriate treatment strategy. In clinical practice, a comprehensive approach that integrates several parameters of valve morphology and function assessed with 2D/3D transthoracic and transoesophageal echocardiography is a key to appropriately detect and quantitate PHV dysfunction. Cinefluoroscopy, multidetector computed tomography, cardiac magnetic resonance imaging, and to a lesser extent, nuclear imaging are complementary tools for the diagnosis and management of PHV complications. The present document provides recommendations for the use of multimodality imaging in the assessment of PHVs. [less ▲]Detailed reference viewed: 37 (2 ULg) Adaptation posologique des médicaments et fonction rénale : Quel(s) estimateur(s) faut-il choisir?DELANAYE, Pierre ; Flamant, M; CAVALIER, Etienne et alin Néphrologie & Thérapeutique (2016), 12(1), 18-31Le choix de la formule d’estimation du de´ bit de filtration glomérulaire (DFG) a utiliser pour l’adaptation posologique fait encore de´ bat, principalement entre la formule de Cockcroft et les équations ... [more ▼]Le choix de la formule d’estimation du de´ bit de filtration glomérulaire (DFG) a utiliser pour l’adaptation posologique fait encore de´ bat, principalement entre la formule de Cockcroft et les équations plus récentes, MDRD (pour Modified Diet in Renal Disease) et CKD-EPI (pour Chronic Kidney Disease Epidemiology). Les arguments mis en avant en faveur de l’utilisation de la formule de Cockcroft sont : qu’elle a été préférentiellement utilisée pour décider des adaptations posologiques avant la mise sur le marché des médicaments, qu’elle permettrait une meilleure prédiction du risque de survenue des effets indésirables a l’accumulation des médicaments, qu’elle permettrait de limiter le surdosage médicamenteux chez la personne âgée. Dans cet article d’opinion, nous discutons les faiblesses de l’argumentaire des partisans du maintien de l’utilisation de la formule de Cockcroft dans le contexte de l’adaptation posologique, ainsi que les limites et le manque de fiabilité de cette formule. Nous soutenons la recommandation de la Haute Autorité de sante´ (HAS) sur l’utilisation systématique, en 2015, de l’équation CKD-EPI pour l’estimation du DFG. Lorsque le DFG est e´ value´ dans le but d’adapter la posologie d’un médicament, la désindexation de la surface corporelle est préférable. Compte tenu des difficultés d’estimation du DFG chez la personne âgée et chez les individus a gabarit hors norme, nous recommandons d’utiliser en priorité dans ces populations, des médicaments pour lesquels un suivi pharmacologique est disponible, ou d’avoir recours à une méthode de référence de mesure du DFG. [less ▲]Detailed reference viewed: 49 (3 ULg) Fabrication and characterization of polymer membranes with integrated arrays of high performance micro-magnetsRoy, D. L.; Shaw, Gorky ; Haettel, R. et alin Materials Today Communications (2016), 6Detailed reference viewed: 12 (6 ULg) Clostridium difficile presence in Spanish and Belgian hospitalsRodriguez Diaz, Cristina ; Fernadez, Jonathan; Van Broeck, Johan et alin Microbial Pathogenesis (2016), 100Clostridium difficile is recognised worldwide as the main cause of infectious bacterial antibiotic-associated diarrhoea in hospitals and other healthcare settings. The aim of this study was to first ... [more ▼]Clostridium difficile is recognised worldwide as the main cause of infectious bacterial antibiotic-associated diarrhoea in hospitals and other healthcare settings. The aim of this study was to first survey C. difficile prevalence during the summer of 2014 at the Central University Hospital of Asturias (Spain). By typing the isolates obtained, it was then possible to compare the ribotype distribution at the Spanish hospital with results from the St Luc University Hospital in Belgium over the same period. The prevalence of positive cases reported in Spain and Belgium was 12.3% and 9.3% respectively. The main PCR-ribotypes previously described in Europe were found in both hospitals, including 078, 014, 012, 020 and 002. In the Spanish hospital, most of the C. difficile-positive samples were referred from oncology, acute care and general medicine services. In the Belgian hospital the majority of positive samples were referred from the paediatric service. However, a high percentage of isolates from this service were non-toxigenic. This study finds that the presence and detection of C. difficile in paediatric and oncology services requires further investigation. [less ▲]Detailed reference viewed: 19 (4 ULg) Efficacy and safety of hyaluronic acid in the management of osteoarthritis : Evidence from real-life setting trials and surveys.Maheu, E.; Rannou, F.; Reginster, Jean-Yves in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 28-33The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee ... [more ▼]The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee osteoarthritis (OA) as second-line treatment in patients who remain symptomatic despite use of non-steroidal anti-inflammatory drugs (NSAIDs). This recommendation is based upon accumulating evidence that IA HA provides a significant benefit in knee OA. There is good evidence that IA HA injections reduce pain and increase function in knee OA, and the benefits are long-lasting as compared with IA corticosteroids. Evidence from real-life studies of repeat courses of IA HA demonstrates an improvement in pain or function lasting up to 40 months (12 months after the last injection cycle), a reduction in use of concomitant analgesia by up to 50%, and suggests that there may be a delay in the need for total knee replacement (TKR) of around 2 years. The clinical benefit of IA HA on knee OA may be 2-fold: (i) mechanical viscosupplementation of the joint (allowing lubrication and shock absorption) and (ii) the re-establishment of joint homeostasis through induction of endogenous HA production, which continues long after the exogenous injection has left the joint.The magnitude of the clinical effect may be different for different HA products, but this has not been proven so far and requires further investigation. IA HA injections are generally considered to be safe,although a slightly higher number of cases of local reactions and post-injection non-septic arthritis has been reported with high molecular weight cross-linked HAs. The use of IA HA in knee OA patients with mild–moderate disease, and for more severe patients wishing to delay TKR surgery,is recommended by the ESCEO taskforce. Further investigation into the OA patient types most likely to benefit from IA HA is warranted. Viscosupplementation with IA HA is a safe and effective component of the multi-modal management of knee OA. [less ▲]Detailed reference viewed: 19 (6 ULg) Is individual consistency in body mass and reproductive decisions linked to individual specialization in foraging behavior in a long-lived seabird?Dehnhard, Nina; Eens, Marcel; Sturaro, Nicolas et alin Ecology and Evolution (2016)Individual specialization in diet or foraging behavior within apparently generalist populations has been described for many species, especially in polar and temperate marine environments, where resource ... [more ▼]Individual specialization in diet or foraging behavior within apparently generalist populations has been described for many species, especially in polar and temperate marine environments, where resource distribution is relatively predictable. It is unclear, however, whether and how increased environmental variability – and thus reduced predictability of resources – due to global climate change will affect individual specialization. We determined the within- and among-individual components of the trophic niche and the within-individual repeatability of d13C and d15N in feathers and red blood cells of individual female southern rockhopper penguins (Eudyptes chrysocome) across 7 years. We also investigated the effect of environmental variables (Southern Annular Mode, Southern Oscillation Index, and local sea surface temperature anomaly) on the isotopic values, as well as the link between stable isotopes and female body mass, clutch initiation dates, and total clutch mass. We observed consistent red blood cell d13C and d15N values within individuals among years, suggesting a moderate degree of within-individual specialization in C and N during the prebreeding period. However, the total niche width was reduced and individual specialization not present during the premolt period. Despite significant interannual differences in isotope values of C and N and environmental conditions, none of the environmental variables were linked to stable isotope values and thus able to explain phenotypic plasticity. Furthermore, neither the within-individual nor among-individual effects of stable isotopes were found to be related to female body mass, clutch initiation date, or total clutch mass. In conclusion, our results emphasize that the degree of specialization within generalist populations can vary over the course of 1 year, even when being consistent within the same season across years. We were unable to confirm that environmental variability counteracts individual specialization in foraging behavior, as phenotypic plasticity in d13C and d15N was not linked to any of the environmental variables studied. [less ▲]Detailed reference viewed: 15 (3 ULg) Quantification of paravalvular regurgitation after transcatheter aortic valve implantation: improved accuracy means better standardization.Lancellotti, Patrizio ; Piazza, Nicolo; Modine, Thomasin European Heart Journal - Cardiovascular Imaging (2016)Detailed reference viewed: 4 (0 ULg) Clostridium difficile in foods and animals: A comprehensive reviewRodriguez Diaz, Cristina ; Taminiau, Bernard ; Van Broeck, Johan et alin Advances in Experimental Medicine and Biology (2016), 27Detailed reference viewed: 49 (5 ULg) Assessment of the entering stock, migration dynamics and fish pass fidelity of european eel in the belgian meuse riverNzau Matondo, Billy ; Benitez, Jean-Philippe ; Dierckx, Arnaud et alin River Research & Applications (2016)Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to ... [more ▼]Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to distinguish resident and migrating eels. From April to September 2013, 435 eels (P50 length, 403 mm; range, 196–836 mm) were caught (daily maxima catch, 90 eels per day), 90% between 13 June and 1 August (50 days) and P50 on 19 July. Eels migrated mostly at 19–26 °C (P50, 24.4 °C), river discharge 65–314m3 s 1 (P50, 84m3 s 1), during the dark at 00:00–05:00 h and during both the waxing and waning phases of moonlight. From 396 eels tagged and released 0.3 km downstream of the Lixhe dam, 6.8% of them were recaptured, and 37.4% were detected. Migration flux was estimated at 7184 eels (0.863 t) using the markrecapture method and decreased to 1156 eels (0.139 t) using automatic transponder detection. Most eels probably migrated through a sluice located downstream of Lixhe to reach the upper Meuse via the Albert Canal. Eels moved almost independently to the configuration of the fish passes and their location, but most eels displayed fidelity to the fish pass where they were captured. Migrant eels showed a wide range of size and life stages, with a higher proportion of eels (80%) belonging to the yellow eel stage. A lower proportion of eels (6%) had a larger size and presented an advanced continental silvering process corresponding to the migrating stage before their transatlantic migration. Copyright © 2016 John Wiley & Sons, Ltd. [less ▲]Detailed reference viewed: 28 (9 ULg) Lumbopelvic motor control and low back pain in elite soccer players: a cross-sectional studyGROSDENT, Stéphanie ; Demoulin, Christophe ; Rodriguez de la Cruz, Carlos et alin Journal of Sports Sciences (2016)This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1 ... [more ▼]This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1.4 years) filled in questionnaires related to low back pain and attended a session to assess lumbopelvic motor control by means of five tests (the bent knee fall out test, the knee lift abdominal test, the sitting knee extension test, the waiter ’ s bow and the transversus abdominis test). A physiotherapist, blinded to the medical history of the participants, scored (0 = failed, 1 = correct) the performance of the players for each of the tests resulting in a lumbopelvic motor control score ranging from 0 to 5. Forty-seven per cent of the soccer players reported a disabling low back pain episode lasting at least two consecutive days in the previous year. These players scored worse lumbopelvic motor control than players without a history of low back pain (lumbopelvic motor control score of 1.8 vs. 3.3, P < 0.01). The between-groups difference was particularly marked for the bent knee fall out test, the knee lift abdominal test and the transversus abdominis test (P < 0.01). In conclusion, most soccer players with a history of low back pain had an altered lumbopelvic motor control. Further research should examine whether lumbopelvic motor control is etiologically involved in low back pain episodes in soccer players. [less ▲]Detailed reference viewed: 54 (19 ULg) Generalized Pascal triangle for binomial coefficients of wordsLeroy, Julien ; Rigo, Michel ; Stipulanti, Manon in Advances in Applied Mathematics (2016), 80We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word ... [more ▼]We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word. Similarly to the Sierpiński gasket that can be built as the limit set, for the Hausdorff distance, of a convergent sequence of normalized compact blocks extracted from Pascal triangle modulo 2, we describe and study the first properties of the subset of [0, 1] × [0, 1] associated with this extended Pascal triangle modulo a prime p. [less ▲]Detailed reference viewed: 83 (50 ULg) Validation of the Marijuana Effect Expectancies Questionnaire (MEEQ) in a Non-Clinical French-Speaking Adolescent SampleSchmits, Emilie ; Quertemont, Etienne ; Guillem, Eric et alin Psychologica Belgica (2016), 56Detailed reference viewed: 31 (1 ULg) Deux décennies de FLESDefays, Jean-Marc ; Meunier, Deborah in Les Cahiers de l'ASDIFLE (2016), 27(111), Detailed reference viewed: 13 (3 ULg) ON THE USE OF HIGH-THROUGHPUT SEQUENCING FOR THE STUDY OF CYANOBACTERIAL DIVERSITY IN ANTARCTIC AQUATIC MATS 1Stelmach Pessi, Igor ; De Carvalho Maalouf, Pedro; Laughinghouse, Haywood Dail et alin Journal of Phycology (2016), 52The study of Antarctic cyanobacterial diversity has been mostly limited to morphological identification and traditional molecular techniques. High-throughput sequencing (HTS) allows a much better ... [more ▼]The study of Antarctic cyanobacterial diversity has been mostly limited to morphological identification and traditional molecular techniques. High-throughput sequencing (HTS) allows a much better understanding of microbial distribution in the environment, but its application is hampered by several methodological and analytical challenges. In this work we explored the use of HTS as a tool for the study of cyanobacterial diversity in Antarctic aquatic mats. Our results highlight the importance of using artificial communities to validate the parameters of the bioinformatics procedure used to analyse natural communities, since pipeline-dependent biases had a strong effect on the observed community structures. Analysis of microbial mats from five Antarctic lakes and an aquatic biofilm from the Sub-Antarctic showed that HTS is a valuable tool for the assessment of cyanobacterial diversity. The majority of the OTUs retrieved were related to filamentous taxa such as Leptolyngbya and Phormidium, which are common genera in Antarctic lacustrine microbial mats. However, other phylotypes related to different taxa such as Geitlerinema, Pseudanabaena, Synechococcus and Chamaesiphon, Calothrix and Coleodesmium were also found. Results revealed a much higher diversity than what had been reported using traditional methods and also highlighted remarkable differences between the cyanobacterial communities of the studied lakes. The aquatic biofilm from the Sub-Antarctic had a distinct cyanobacterial community in comparison to the studied Antarctic lakes, which, in turn, displayed a salinity-dependent community-structure at the phylotype level. [less ▲]Detailed reference viewed: 31 (14 ULg) One-pot synthesis of double poly(ionic liquid) block copolymers by cobalt-mediated radical polymerization-induced self assembly (CMR-PISA) in waterCordella, Daniela ; Debuigne, Antoine ; Jérôme, Christine et alin Macromolecular Rapid Communications (2016), 37(14), 1181-1187Amphiphilic double poly(ionic liquid) (PIL) block copolymers are directly prepared by cobalt- mediated radical polymerization induced self-assembly (CMR-PISA) in water of N-vinyl imida- zolium monomers ... [more ▼]Amphiphilic double poly(ionic liquid) (PIL) block copolymers are directly prepared by cobalt- mediated radical polymerization induced self-assembly (CMR-PISA) in water of N-vinyl imida- zolium monomers carrying distinct alkyl chains. The cobalt-mediated radical polymerization of N-vinyl-3-ethyl imidazolium bromide (VEtImBr) is first carried out until high conversion in water at 30 °C, using an alkyl bis(acetylacetonate)cobalt(III) adduct as initiator and con- trolling agent. The as-obtained hydrophilic poly(N-vinyl-3- ethyl imidazolium bromide) (PVEtImBr) is then used as a macroinitiator for the CMR-PISA of N-vinyl-3-octyl imidazo- lium bromide (VOcImBr). Self-assembly of the amphiphilic PVEtImBr-b-PVOcImBr block copolymer, i.e., of PIL-b-PIL-type, rapidly takes place in water, forming polymer nanoparticles consisting of a hydrophilic PVEtImBr corona and a hydro- phobic PVOcImBr core. Preliminary investigation into the effect of the size of the hydrophobic block on the dimension of the nanoparticles is also described. [less ▲]Detailed reference viewed: 74 (23 ULg) Energy and nutrient content of food served and consumed by nursing home residentsBuckinx, Fanny ; ALLEPAERTS, Sophie ; PAQUOT, Nicolas et alin the journal of nutrition, health & aging (2016), in pressObjective: The aim of this study was to compare energy and protein content of the served food with the actual intake from the food consumed by nursing home residents. This study also aimed to compare food ... [more ▼]Objective: The aim of this study was to compare energy and protein content of the served food with the actual intake from the food consumed by nursing home residents. This study also aimed to compare food intake and dietary allowances. Design: This is a cross sectional study. Setting: This study was performed in nursing homes. Participants: Residents of these 2 nursing homes were eligible for the study if they agreed to participate and if they meet the selection criteria (to be older than 65 years and have a regular texture diet). Measurement: Nutrient content of the served food and real food consumption was calculated for all meals during a 5-day period by precise weighting method. Difference between consumed and served dietary content was evaluated by the Chi² test. Results: Seventy-four Belgian nursing home residents (75% of women, 85.8 ± 7.04 years on average) were included in this study. These subjects had a mean body mass index of 24.9 ± 4.83 kg/m². The mean energy content of the served food was 1783.3 ± 125.7 kcal per day. However, residents did not eat the whole of the meals and the actual energy content of the consumed food was significantly less (1552.4 ± 342.1 kcal per day; p<.001). The average protein content of the food served was equal to 0.96 ± 0.20 g/kg/day and the average consumption of protein by the residents was 0.88 ± 0.25 g/kg/day. The difference between protein served and consumed was also significant (p=.04). Moreover, people considered as well nourished, eating significantly more energy than the others (p=.04). Conclusion: Meals served in nursing homes are not entirely consumed by their residents. As expected, the energy consumed are lower in subjects considered as malnourished or at risk of malnutrition. [less ▲]Detailed reference viewed: 13 (2 ULg) LA PARTICIPATION DES USAGERS COMME LEVIER DE L’INNOVATION DANS LES SERVICES PUBLICS : LE CAS DE LA GÉOMATIQUE WALLONNEFallon, Catherine ; Calay, Vincentin Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2016), 26/27La numérisation des données géographiques est une de ces techniques récentes qui transforment à la fois la structure politico-administrative et la construction des politiques elles-mêmes en transformant ... [more ▼]La numérisation des données géographiques est une de ces techniques récentes qui transforment à la fois la structure politico-administrative et la construction des politiques elles-mêmes en transformant le réseau d’action publique. Ces données peuvent être utilisées dans la plupart des politiques, pourvu que les questions de distribution territoriales y soient pertinentes : on parle en ce sens d’une « géomatisation » de l’action publique. Le cadre européen avec la directive INSPIRE a donné l’impulsion et définit le cadre de référence pour une refonte des processus de production et de diffusion des données géographiques numériques. Les états doivent chacun établir une infrastructure de données géographiques numériques pour assurer l’interopérabilité entre bases de données et faciliter la diffusion, la disponibilité, l'utilisation et la réutilisation de l’information géographique au niveau de leur territoire et en Europe. En Belgique, ce sont les régions - et le niveau fédéral pour ses compétences - qui ont hérité de cette responsabilité : leurs données doivent être mises à disposition des utilisateurs, qu’ils soient décideurs ou citoyens dans des formats harmonisés afin d'en faciliter l'utilisation par tous et il faut aussi définir les principes d’échange, de tarification et les conditions d’utilisation propres à faciliter l’accès aux données et aux services en ligne. Les données géographiques numérisées ont ceci de particulier qu’elles sont produites de façon décentralisées par des acteurs publics mais aussi privés, lesquels cherchent à peser sur les choix stratégiques des autorités régionales. Au niveau de la Région wallonne a été mis en place récemment un ensemble de structure de coopération avec les usagers, les entreprises, et les autorités locales. L’administration a créé en son sein des groupes de travail transversaux pour améliorer l’intégration entre les approches thématiques contrôlées par les différentes directions. Le projet d’article trouve son origine dans l’accompagnement assuré par le SPIRAL au Département de la géomatique de la Région wallonne dans le cadre de la rédaction du plan stratégique et du plan opérationnel de la géomatique wallonne (2013-2015). L’article prendra appui sur les principes de la sociologie de la traduction (Callon, 1986) pour proposer une analyse des lieux et des processus qui contribuent à mettre en place une « gouvernance en réseau » mobilisant une logique d’innovation publique (Sørensen et al. 2011), sans suspendre pour autant les formes de coordination hiérarchiques et contractuelles. [less ▲]Detailed reference viewed: 60 (2 ULg) Impact of cyclonic and anticyclonic activity on Greenland ice sheet surface mass balance variation during 1980–2013Chen, L.; Fettweis, Xavier ; Knudsen, E. et alin International Journal of Climatology (2016)The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective ... [more ▼]The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective, extratropical cyclones and anticyclones are the major systems influencing Greenland weather conditions. Seasonal cyclonic and anticyclonic activities have been quantified for the area of 50°–90°N, 80°W–10°E during 1980–2013. Based on a singular value decomposition (SVD) analysis, we investigated the role of synoptic scale cyclonic and anticyclonic activities in determining snow accumulation (SA) and surface air temperature (SAT). Thus, the SA-driven and melt-driven SMB variability has been determined. SA-related synoptic patterns identified from the leading and the second SVD modes explain up to 80% of the inter-annual SMB variance, especially in southern and northwestern Greenland, where we found the largest and second largest amount of annual SA. SAT-related patterns account for up to 80% of the inter-annual SMB variation along the west and northwest coast of Greenland, where significant surface mass loss has been observed over the last decades. It should be noted that the negative phase of the SA-related pattern derived from the first SVD mode in June-July-August and the positive phase of the SAT-related (anti)cyclonic patterns have occurred more frequently since 2005, meaning that the phase change of these patterns has made a major contribution to the accelerated GrIS surface ice loss during recent years. [less ▲]Detailed reference viewed: 73 (5 ULg) Deterring the State Versus the Firm: Soft and Hard Deterrence Regimes in EU LawPetit, Nicolas ; Bogojević, Sanjain Columbia Journal of European Law (2016), Vol. 23This paper sheds light on the existence of a differential deterrence regime in EU law, depending on whether the State or the firm is the addressee of a legal obligation. To that end, we review two areas ... [more ▼]This paper sheds light on the existence of a differential deterrence regime in EU law, depending on whether the State or the firm is the addressee of a legal obligation. To that end, we review two areas of EU law – environmental law and competition law. Both disciplines employ fines to deter the State and the firm respectively from violating their specific duties under the Treaty: the ‘duty to transpose’ with regard to State obligation under environmental law, and the ‘duty to compete’ in relation to firms under competition law. We show how the deterrence regime is softer on the State in at least three ways: functionally (purpose ascribed to the penalties), operationally (method followed to set and liquidate the penalty), and procedurally (requiring prior judicial approval as opposed to having immediate applicability). These findings are significant for two reasons: they suggest a State versus firm discrepancy in the EU’s deterrence regime, and serve to initiate a debate on the desirability of such a divide. [less ▲]Detailed reference viewed: 11 (1 ULg) Facteurs pronostiques du cancer pulmonaire non à petites cellulesGESTER, Fanny; PAULUS, Astrid ; SIBILLE, Anne et alin Revue Médicale de Liège (2016), 71(1), 34-39Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of ... [more ▼]Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of a surgical management with curative intent. This paper gives an overview of the main prognostic factors, the two most important of which remain the staging and tumor histology. These also determine the therapeutic strategy. Other factors of poor prognosis might also be useful for clinicians, particularly in their decision to refer patients for adjuvant therapies. Keywords : Non-small cell lung cancer – Prognostic factors – Pulmonary oncology – Surgery [less ▲]Detailed reference viewed: 43 (10 ULg) Permeability evolution and water transfer in the excavation damaged zone of a ventilated galleryPardoen, Benoît ; Talandier, Jean; Collin, Frédéric in International Journal of Rock Mechanics & Mining Sciences (2016), 85The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers ... [more ▼]The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers are mainly conditioned by the behaviour of the surrounding material and by its interaction with the gallery air. The hydro-mechanical behaviour of the excavation damaged zone, which develops around galleries due to the drilling process, is thenceforward critical because it is composed of fractures having a significant irreversible impact on flow characteristics and transfer kinetics. Besides, the material interaction with the gallery air may engender water drainage and desaturation. Thus, a gallery air ventilation experiment, preceded by its excavation, is numerically modelled in an unsaturated argillaceous rock to study its influence on hydraulic transfers. The fractures are numerically represented with shear strain localisation bands by means of a microstructure enriched model including a regularisation method. The impact of fracturing on the transport properties is addressed by associating the intrinsic permeability increase with mechanical deformation which is amplified in the strain localisation discontinuities. Such dependence permits us to reproduce a significant permeability increase of several orders of magnitude in the excavation damaged zone, in agreement with available experimental measurements. After the excavation, the hydraulic transfers are studied through the reproduction of a gallery air ventilation experiment that implies drainage and desaturation of the surrounding rock. These transfers depend on liquid water and water vapour exchanges at gallery wall that are introduced through a non-classical boundary condition. The model prediction successfully captures the drainage and desaturation kinetics of undisturbed and damaged rock. [less ▲]Detailed reference viewed: 41 (2 ULg) « La Théorie critique n’a aucun rapport avec la société. » Kluge, Adorno et l’indomptable Leni PeickertHamers, Jérémy ; Cormann, Grégory in Tijdschrift voor Filosofie (2016), 78(1), 97-120In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to ... [more ▼]In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to create a « reformed circus » which aims at reintroducing some sensuality in the spectator’s experience. Taking this project as well as its central figure, the apparently passive elephant, as a metaphorical starting point, this article reconstitutes a virtual dialogue between the filmmaker and his friend and former master Theodor W. Adorno around the issue of communicability and effectiveness of Critical Theory. Crossing several text fragments by the philosopher (Dialectic of Enlightenment, Resignation and Education After Auschwitz a.o.) with film excerpts, short stories and interviews by Kluge, this dialogue made of real exchanges, as well as direct and indirect quotes of Adorno in Kluge’s films – considered here to be belated joint projects –, finally tries to give an answer to following crucial question: how can Adorno’s critical reflection remain politically, that is socially effective. [less ▲]Detailed reference viewed: 61 (5 ULg) Le « mot-phrase » dans les conceptions syntaxiques de Lucien TesnièreMazziotta, Nicolas ; Kahane, Sylvainin Bulletin de la Société de Linguistique de Paris (2016), 111(1), 71-107Several of Tesnière's drafts and files that remain available at the Bibliothèque nationale de France provide materials for a renewed approach of the concept of mot-phrase (lit. ‘sentence word’, also ... [more ▼]Several of Tesnière's drafts and files that remain available at the Bibliothèque nationale de France provide materials for a renewed approach of the concept of mot-phrase (lit. ‘sentence word’, also called phrasillon), a category close to the traditional heterogeneous class of interjections. In the Éléments de syntaxe structurale, Tesnière states that the mot-phrase is used as a sentence and that it lacks syntactic properties at a lower level. It is therefore considered irrelevant for the study of syntax. However, this stance contrasts with Tesnière's previous views on the matter. This paper contains an edited version of a draft entitled Chapitre I. - Les mots phrases ou phrasillons. Comparing the contents delivered by this document with Tesnière's published works helps us understand the difficulties he experienced to classify the mot-phrase among other parts of speech with respect to their syntactic properties : their relationships with governor words and dependents, as well as their behaviours in the system of transfer. [less ▲]Detailed reference viewed: 16 (3 ULg) Current Changes in Pubertal Timing: Revised Vision in Relation with Environmental Factors Including Endocrine Disruptors.Parent, Anne-Simone ; Franssen, Delphine ; Fudvoye, Julie et alin Endocrine development (2016), 29The aim of this chapter is to revise some common views on changes in pubertal timing. This revision is based on recent epidemiological findings on the clinical indicators of pubertal timing and data on ... [more ▼]The aim of this chapter is to revise some common views on changes in pubertal timing. This revision is based on recent epidemiological findings on the clinical indicators of pubertal timing and data on environmental factor effects and underlying mechanisms. A current advancement in timing of female puberty is usually emphasized. It appears, however, that timing is also changing in males. Moreover, the changes are towards earliness for initial pubertal stages and towards lateness for final stages in both sexes. Such observations indicate the complexity of environmental influences on pubertal timing. The mechanisms of changes in pubertal timing may involve both the central neuroendocrine control and peripheral effects at tissues targeted by gonadal steroids. While sufficient energy availability is a clue to the mechanism of pubertal development, changes in the control of both energy balance and reproduction may vary under the influence of common determinants such as endocrine-disrupting chemicals (EDCs). These effects can take place right before puberty as well as much earlier, during fetal and neonatal life. Finally, environmental factors can interact with genetic factors in determining changes in pubertal timing. Therefore, the variance in pubertal timing is no longer to be considered under absolutely separate control by environmental and genetic determinants. Some recommendations are provided for evaluation of EDC impact in the management of pubertal disorders and for possible reduction of EDC exposure along the precautionary principle. [less ▲]Detailed reference viewed: 47 (11 ULg) The terrestrialization process: A palaeobotanical and palynological perspective.Meyer-Berthaud, Brigitte; Servais, Thomas; Vecoli, Marco et alin Review of Palaeobotany and Palynology (2016), 224(Part 1), 1-3Detailed reference viewed: 63 (3 ULg) Transatlantic Editorial: a comparison between European and North American guidelines on myocardial revascularization.Kolh, Philippe ; Kurlansky, Paul; Cremer, Jochen et alin European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(5), 1307-17Detailed reference viewed: 6 (0 ULg) Insight into SUCNR1 (GPR91) structure and functionGilissen, Julie ; Jouret, François ; Pirotte, Bernard et alin Pharmacology & Therapeutics (2016)SUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR), which represents the largest group of membrane proteins in human genome. The majority of marketed drugs targets GPCRs ... [more ▼]SUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR), which represents the largest group of membrane proteins in human genome. The majority of marketed drugs targets GPCRs, directly or indirectly. SUCNR1 has been classified as an orphan receptor until a landmark study paired it with succinate, a citric acid cycle intermediate. According to the current paradigm, succinate triggers SUCNR1 signaling pathways to indicate local stress that may affect cellular metabolism. SUCNR1 implication has been well documented in renin-induced hypertension, ischemia/reperfusion injury, inflammation and immune response, platelet aggregation and retinal angiogenesis. In addition, the SUCNR1-induced increase of blood pressure may contribute to diabetic nephropathy or cardiac hypertrophy. The understanding of SUCNR1 activation, signaling pathways and functions remains largely elusive, which calls for deeper investigations. SUCNR1 shows a high potential as an innovative drug target and is probably an important regulator of basic physiology. In order to achieve the full characterization of this receptor,more specific pharmacological tools such as small-molecules modulators will represent an important asset. In this review, we describe the structural features of SUCNR1, its current ligands and putative binding pocket. We give an exhaustive overview of the known and hypothetical signaling partners of the receptor in different in vitro and in vivo systems. The link between SUCNR1 intracellular pathways and its pathophysiological roles are also extensively discussed. [less ▲]Detailed reference viewed: 40 (13 ULg) In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market.Geris, Liesbet ; Guyot, Y.; Schrooten, J. et alin Interface focus (2016), 6(2), 20150105The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as ... [more ▼]The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as academic research institutes are in need of tools to advance their understanding and, at the same time, reduce their R&D costs, increase product quality and productivity, and reduce the time to market. An additional difficulty is the regulatory path that needs to be followed, which is challenging in the case of cell-based therapeutic products and should rely on the implementation of quality by design (QbD) principles. In silico modelling is a tool that allows the above-mentioned challenges to be addressed in the field of regenerative medicine. This review discusses such in silico models and focuses more specifically on the bioprocess. Three (clusters of) examples related to this subject are discussed. The first example comes from the pharmaceutical engineering field where QbD principles and their implementation through the use of in silico models are both a regulatory and economic necessity. The second example is related to the production of red blood cells. The described in silico model is mainly used to investigate the manufacturing process of the cell-therapeutic product, and pays special attention to the economic viability of the process. Finally, we describe the set-up of a model capturing essential events in the development of a tissue-engineered combination product in the context of bone tissue engineering. For each of the examples, a short introduction to some economic aspects is given, followed by a description of the in silico tool or tools that have been developed to allow the implementation of QbD principles and optimal design. [less ▲]Detailed reference viewed: 6 (1 ULg) Simultaneous multi-scale and multi-instrument observations of Saturn's aurorae during the 2013 observing campaignMelin, H.; Badman, S.; Stallard, T. et alin Icarus (2016)Detailed reference viewed: 9 (1 ULg) COMPUTED TOMOGRAPHY AND MAGNITEC RESONANCE FINDINGS IN ATHLETES AT RISK FOR SUDDEN CARDIAC DEATHGHEKIERE, olivier; Nchimi Longang, Alain ; BIJNENES, Eric et alin Journal of the Belgian Society of Radiology (2016), 44Detailed reference viewed: 19 (2 ULg) A Belgian Survey on Geriatric Assessment in Oncology Focusing on Large-Scale Implementation and Related Barriers and Facilitators.Kenis, C.; Heeren, P.; Decoster, L. et alin The journal of nutrition, health & aging (2016), 20(1), 60-70OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for ... [more ▼]OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for implementing GA in this setting. Design / setting / participants: The principal investigator of every participating hospital (n=22) was invited to complete a newly developed questionnaire with closed- and open-ended questions. The closed-ended questions surveyed how GA was implemented. The open-ended questions identified barriers and facilitators for the implementation of GA in daily oncology practice. Descriptive statistics and conventional content analysis were performed as appropriate. RESULTS: Qualifying criteria (e.g. disease status and cancer type) for GA varied substantially between hospitals. Thirteen hospitals (59.1%) succeeded to screen more than half of eligible patients. Most hospitals reported that GA data and follow-up data had been collected in almost all screened patients. Implementing geriatric recommendations and formulating new geriatric recommendations at the time of follow-up are important opportunities for improvement. The majority of identified barriers were organizational, with high workload, lack of time or financial/staffing problems as most cited. The most cited facilitators were all related to collaboration. CONCLUSION: Interventions to improve the implementation of GA in older patients with cancer need to address a wide range of factors, with organization and collaboration as key elements. All stakeholders, seeking to improve the implementation of GA in older patients with cancer, should consider and address the identified barriers and facilitators. [less ▲]Detailed reference viewed: 13 (5 ULg) Crop model improvement reduces the uncertainty of the response to temperature of multi-model ensemblesMaiorano, Andrea; Martre, Pierre; Asseng, Senthold et alin Field Crops Research (2016), In presso improve climate change impact estimates and to quantify their uncertainty, multi-model ensembles (MMEs) have been suggested. Model improvements can improve the accuracy of simulations and reduce the ... [more ▼]o improve climate change impact estimates and to quantify their uncertainty, multi-model ensembles (MMEs) have been suggested. Model improvements can improve the accuracy of simulations and reduce the uncertainty of climate change impact assessments. Furthermore, they can reduce the number of models needed in a MME. Herein, 15 wheat growth models of a larger MME were improved through re-parameterization and/or incorporating or modifying heat stress effects on phenology, leaf growth and senescence, biomass growth, and grain number and size using detailed field experimental data from the USDA Hot Serial Cereal experiment (calibration data set). Simulation results from before and after model improvement were then evaluated with independent field experiments from a CIMMYT world-wide field trial network (evaluation data set). Model improvements decreased the variation (10th to 90th model ensemble percentile range) of grain yields simulated by the MME on average by 39% in the calibration data set and by 26% in the independent evaluation data set for crops grown in mean seasonal temperatures >24 °C. MME mean squared error in simulating grain yield decreased by 37%. A reduction in MME uncertainty range by 27% increased MME prediction skills by 47%. Results suggest that the mean level of variation observed in field experiments and used as a benchmark can be reached with half the number of models in the MME. Improving crop models is therefore important to increase the certainty of model-based impact assessments and allow more practical, i.e. smaller MMEs to be used effectively. [less ▲]Detailed reference viewed: 17 (1 ULg) La pensée future épisodique : entre simulation et contexte autobiographiqueD'Argembeau, Arnaud in Revue de Neuropsychologie (2016), 8Detailed reference viewed: 24 (5 ULg) Distribution of heavy and clay minerals in coastal sediment of jijel, East of Algeria: indicators of sediment sources and transport and deposition environmentsKERMANI, S.; BOUTIBA, M.; BOUTALEB, A. et alin Arabian Journal of Geosciences (2016)Detailed reference viewed: 115 (30 ULg) Introduction. Exercer les rhétoriques du peupleGoin, Emilie ; Provenzano, François in Exercices de rhétorique (2016), 7Detailed reference viewed: 14 (1 ULg) Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota.Neyrinck, Audrey M.; Etxeberria, Usune; Taminiau, Bernard et alin Molecular Nutrition & Food Research (2016)SCOPE: Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by inflammation and oxidative stress, which could be promoted by gut barrier function ... [more ▼]SCOPE: Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by inflammation and oxidative stress, which could be promoted by gut barrier function alterations. In this study, we have tested the hypothesis of the hepatoprotective effect of rhubarb extract in a mouse model of binge drinking and we explored the contribution of the gut microbiota in the related- metabolic effects. METHODS AND RESULTS: Mice were fed a control diet supplemented with or without 0.3% rhubarb extract for 17 days and were necropsied 6 hours after an alcohol challenge. Supplementation with rhubarb extract changed the microbial ecosystem (assessed by 16S rDNA pyrosequencing) in favor of Akkermansia muciniphila and Parabacteroides goldsteinii. Furthermore, it improved alcohol-induced hepatic injury, down-regulated key markers of both inflammatory and oxidative stresses in the liver tissue, without affecting significantly steatosis. In the gut, rhubarb supplementation increased crypt depth, tissue weight, the expression of antimicrobial peptides. CONCLUSIONS: These findings suggest that some bacterial genders involved in gut barrier function, are promoted by phytochemicals present in rhubarb extract, and could therefore be involved in the modulation of the susceptibility to hepatic diseases linked to acute alcohol consumption. This article is protected by copyright. All rights reserved. [less ▲]Detailed reference viewed: 16 (3 ULg) Chemical composition of essential oils and floral waters of Mentha longifolia (L.) Huds. from SenegalDiop, Serigne Mbacké; Guèye, Momar Talla; Ndiaye, Ibrahima et alin American Journal of Essential Oils and Natural Products (2016), 4(1), 46-49Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively ... [more ▼]Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively. Analysis of the essential oils, floral waters and the assay of pulegone were carried out by GC/FID and GC/MS. The major compounds identified in the oils were pulegone (52.0 and 42.4%), menthone (14.3 and 21.2%), 1, 8-cineole (13.1 and 11.4%) and isomenthone (9.0 and 13.2%) in the fresh and dried plants, respectively. Analyses revealed that floral waters were also characterized by the same major compounds as essential oils but at different rates. In these floral waters, pulegone constituted 60.2 and 47.0%, 1,8- cineole 7.9 and 19.6%, isomenthone 7.2 and 10.7%, menthone 6.4 and 9.2%, chrysanthenone 6.4 and 3.2% and α-terpineol 3.0 and 2.7% in the fresh and dried plants, respectively. The assay results of pulegone, a hepatotoxic compound, have shown very high levels (444.6 and 393.3mg/g) in both fresh and dried plants. [less ▲]Detailed reference viewed: 33 (4 ULg) Compte-rendu de Pierre-Jean Renaudie, Husserl et les catégories. Langage, pensée et perception, Paris, Vrin, 2015Leclercq, Bruno in Philosophiques (2016), 43(1), 149-153Detailed reference viewed: 26 (0 ULg) Seroprevalence of brucellosis in patients with prolonged fever in BangladeshAnisur Rahman, AKM; Berkvens, D; Saegerman, Claude et alin Journal of Infection in Developing Countries (2016), 10(9), 939-946Detailed reference viewed: 18 (5 ULg) Salicylic acid differently impacts ethylene and polyamine synthesis in the glycophyte Solanum lycopersicum and the wild-related halophyte Solanum chilense exposed to mild salt stresGharbi, Emna; Martinez, Juan Pablo; Benahmed, Hela et alin Physiologia Plantarum (2016), 171This study aimed to determine the effects of exogenous application of salicylic acid on the toxic effects of salt in relation to ethylene and polyamine synthesis, and to correlate these traits with the ... [more ▼]This study aimed to determine the effects of exogenous application of salicylic acid on the toxic effects of salt in relation to ethylene and polyamine synthesis, and to correlate these traits with the expression of genes involved in ethylene and polyamine metabolism in two tomato species differing in their sensitivity to salt stress, Solanum lycopersicum cv Ailsa Craig and its wild salt-resistant relative Solanum chilense. [less ▲]Detailed reference viewed: 29 (6 ULg) Bott type periodicity for the higher octonionsKreusch, Marie in Journal of Noncommutative Geometry (2016), 9(4), 1041-1393We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions ... [more ▼]We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions and Clifford algebras. The algebras $\bbO_{n}$ and $\bbO_{p,q}$ with $p+q=n$ have a natural $\Z_2^n$-grading, and they are characterized by cubic forms over the field $\Z_2$. We establish a periodicity for the algebras~$\bbO_{n}$ and $\bbO_{p,q}$ similar to that of the Clifford algebras $\mathrm{Cl}_{n}$ and~$\mathrm{Cl}_{p,q}$. [less ▲]Detailed reference viewed: 163 (53 ULg) Characterization of almond kernel oils of five almonds varieties cultivated in Eastern MoroccoHoumy, Nadia; Mansouri, F.; Benmoumen, A. et alin Cahiers Options Méditerranéennes (2016)This study focuses on characterization of almondkernel oils extrated mechanically from five sweet almond varieties (Marcona, Fournat, Ferragnes, Ferraduel and Beldi), cultivated in eastern Morocco. Oil ... [more ▼]This study focuses on characterization of almondkernel oils extrated mechanically from five sweet almond varieties (Marcona, Fournat, Ferragnes, Ferraduel and Beldi), cultivated in eastern Morocco. Oil content, physicochemical parameters, triacylglycerol and fatty acid compositions were determined. [less ▲]Detailed reference viewed: 18 (3 ULg) GPR101 mutations are not a frequent cause of congenital isolated growth hormone deficiencyCastinetti, F; Daly, Adrian ; Stratakis, CA et alin Hormone & Metabolic Research (2016)Detailed reference viewed: 30 (9 ULg) What drives the development of community energy in Europe? The case of wind power cooperativesBauwens, Thomas ; Gotchev, Boris; Holstenkamp, Larsin Energy Research & Social Science (2016), 13The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being ... [more ▼]The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being paid to the transition process towards a more decentralized configuration. This article examines the factors likely to foster citizen and community participation as regards wind power cooperatives in Denmark, Germany, Belgium and the UK. Using Elinor Ostrom’s Social-Ecological System Framework, the analysis highlights a double-edged phenomenon: prevailing and growing hostility towards cooperatives, on the one hand, and, on the other, strategic reactions to this evolution. What comes out indeed is that, throughout most of these countries, the emergence of some coordinated inter-organizational actions among cooperatives enables them to survive in their critical environment. [less ▲]Detailed reference viewed: 240 (21 ULg) Sphingolipids: promising lipid-class molecules with potential applications for industry. A reviewMiazek, Krystian ; Lebecque, Simon ; Hamaïdia, Malik et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), (20(S1)), 321-336Detailed reference viewed: 16 (3 ULg) Deciphering how LIP2 and POX2 promoters can optimally regulate recombinant protein production in the yeast Yarrowia lipolytica.Sassi, Hosni; Delvigne, Frank ; Nicaud, Jean-Marc et alin Microbial Cell Factories (2016), 15(1), 159Detailed reference viewed: 18 (3 ULg) Characterization of saccharides released during an in vitro pepsin-pancreatin digestion of corn flour using HPAEC-PADOdjo, Djosse Psijus Sylvanus ; Bera, François ; Jacquet, Nicolas et alin Stärke = Starch (2016), 68Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric ... [more ▼]Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric detector (HPAEC-PAD) and two colorimetric approaches (glucose oxidase/ peroxidase assay and the 3,5-dinitrosalicylic acid assay). HPAEC-PAD revealed five major saccharides as the result of in vitro pepsin-pancreatin digestion of corn grain: glucose, isomaltose, maltose, maltotriose, and glucosyl-maltotriose. Concentrations of glucose released as measured by the three methods assessed are similar when the in vitro pepsin-pancreatin digestion is followed by post incubation with amyloglucosidase. This post incubation unfortunately leads to a loss of information about the degree of polymerization of oligosaccharides that can impact their absorption through intestinal tract. HPAEC-PAD gives both qualitative and quantitative information and then seems more suitable for a nutritional appreciation of the digestion of starchy feedstuffs. [less ▲]Detailed reference viewed: 15 (8 ULg) New features on the environmental regulation of metabolism revealed by modeling the cellular proteomic adaptations induced by light, carbon and inorganic nitrogen in Chlamydomonas reinhardtiiGerin, Stéphanie ; Leprince, Pierre ; Sluse, Francis et alin Frontiers in Plant Science (2016), 7Microalgae are currently emerging to be very promising organisms for the production of biofuels and high-added value compounds. Understanding the influence of environmental alterations on their metabolism ... [more ▼]Microalgae are currently emerging to be very promising organisms for the production of biofuels and high-added value compounds. Understanding the influence of environmental alterations on their metabolism is a crucial issue. Light, carbon and nitrogen availability have been reported to induce important metabolic adaptations. So far, the influence of these variables has essentially been studied while varying only one or two environmental factors at the same time. The goal of the present work was to model the cellular proteomic adaptations of the green microalga Chlamydomonas reinhardtii upon the simultaneous changes of light intensity, carbon concentrations (CO2 and acetate) and inorganic nitrogen concentrations (nitrate and ammonium) in the culture medium. Statistical design of experiments (DOE) enabled to define 32 culture conditions to be tested experimentally. Relative protein abundance was quantified by two dimensional differential in-gel electrophoresis (2D-DIGE). Additional assays for respiration, photosynthesis, and lipid and pigment concentrations were also carried out. A hierarchical clustering survey enabled to partition biological variables (proteins + assays) into eight co-regulated clusters. In most cases, the biological variables partitioned in the same cluster had already been reported to participate to common biological functions (acetate assimilation, bioenergetic processes, light harvesting, Calvin cycle and protein metabolism). The environmental regulation within each cluster was further characterized by a series of multivariate methods including principal component analysis and multiple linear regressions. This metadata analysis enabled to highlight the existence of a clear regulatory pattern for every cluster and to mathematically simulate the effects of light, carbon and nitrogen. The influence of these environmental variables on cellular metabolism is described in details and thoroughly discussed. This work provides an overview of the metabolic adaptations contributing to maintain cellular homeostasis upon extensive environmental changes. Some of the results presented here could be used as starting points for more specific fundamental or applied investigations. [less ▲]Detailed reference viewed: 38 (3 ULg) Contribution à l’écologie des coléoptères coprophiles et coprophages en Belgique : diversité spécifique, préférences stercorales et phénologieBebermans, Julien ; Fagot, Jean ; Francis, Frédéric in Entomologie Faunistique = Faunistic Entomology (2016), 69In a study performed from September to October 2014, coprophagous and coprophilic beetle of cattle and horse dung were observed. This research focused on Scarabaeoidea super-family and Staphylinidae ... [more ▼]In a study performed from September to October 2014, coprophagous and coprophilic beetle of cattle and horse dung were observed. This research focused on Scarabaeoidea super-family and Staphylinidae family. Totally, 6245 individuals, belonging to 15 coprophagous scarabs species and 73 staphylinids species were identified. Insects have been captured using a trap weekly visited. Three geographic regions were compared: Pays de Herve, Hesbaye and Pays Brabançon with one trapping site by region, respectively Julémont, Waremme and Grez-Doiceau. One of the objectives was to observe the insects population diversity according to dung type and identify insect preference related to a specific type of dung. The goal was to observe if the communities change between regions. The population dynamics during the ageing of dung has also been considered. Several species showed a significant preference for one of the two kind of feces, even if there are no strict specialist insects. Also, Julémont appeared as being the most diversified site regarding staphylinds, while Grez-Doiceau seemed to be the most suitable place concerning scarabs. Finally, insects were found to invade very quickly the freshly dropped dung, while they seem less attracted after a few days. [less ▲]Detailed reference viewed: 21 (2 ULg) La Lettonie est à son tour condamnée pour avoir réservé la profession de notaire à ses seuls ressortissantsZians, Audrey in Revue Trimestrielle de Droit Européen (2016), 1(janvier-mars), 205La législation lettonne sur le notariat, en ce qu'elle impose une condition de nationalité à l'accès à la profession de notaire, est jugée contraire à la liberté d'établissement (CJUE 10 septembre 2015 ... [more ▼]La législation lettonne sur le notariat, en ce qu'elle impose une condition de nationalité à l'accès à la profession de notaire, est jugée contraire à la liberté d'établissement (CJUE 10 septembre 2015, aff. C-151/14, Commission/Lettonie, EU:C:2015:577) [less ▲]Detailed reference viewed: 2 (1 ULg) Doped sol–gel films vs. powders TiO2: On the positive effect induced by the presence of a substrateLéonard, Géraldine ; Malengreaux, Charline; Melotte, Quentin et alin Journal of Environmental Chemical Engineering (2016), 4SiO2 and Ag–SiO2 doped TiO2 films and powders have been produced using a controlled sol–gel process. The dopant has been introduced using an alkoxysilane-functionalized ligand, with or without complexed ... [more ▼]SiO2 and Ag–SiO2 doped TiO2 films and powders have been produced using a controlled sol–gel process. The dopant has been introduced using an alkoxysilane-functionalized ligand, with or without complexed silver ions. The influence of dopants on physico-chemical properties of the catalysts is studied by XRD, TEM–EDX, DRUV–vis analyses in the case of powders, while GIXRD, XPS, profilometry, UV–vis absorption analyses have been used for thin films. The photocatalytic activity has been evaluated from the degradation of methylene blue under UV-A light in the presence of the different catalysts over a period of 24 h. The detailed comparison between powders and films highlights a surprising positive effect in the case of films due to the presence of the substrate. In the case of photocatalytic powders, the presence of SiO2 or Ag–SiO2 into the TiO2 matrix has a detrimental effect on the photocatalytic activity while the opposite tendency is observed in the case of films, with best activities obtained with Ag–SiO2 doping. Different factors, in particular crystallinity modification between powders and films, have been studied to explain these opposite behaviors. In the case of powders, crystallization is hindered by SiO2 and Ag particles incorporation into the TiO2 matrix, leading to a decrease of the photocatalytic activity. In the case of thin films, probably because of the presence of a substrate, crystallization is not influenced by the presence of SiO2 and Ag particles. Therefore, the latter ones can fully play their role of electron traps leading to an enhanced photocatalytic activity. [less ▲]Detailed reference viewed: 80 (12 ULg) Analyse statistique des affaires d’ententes dans l’UE (2004-2014)Broos, Sébastien ; Gautier, Axel ; Marcos Ramos, Jorge et alin Revue Economique (2016)Detailed reference viewed: 57 (14 ULg) Effects of microgravity simulation on zebrafish transcriptomes and bone physiology; exposure starting at 5 days post-fertilization.Aceto, Jessica ; Nourizadeh-Lillabadi, Rasoul; Bradamante, Silvia et alin NPJ Microgravity (2016), 2Detailed reference viewed: 26 (2 ULg) Focus sur les astrocytes: cellules de la glie aux rôles multiples et importants dans le SNC. Le mouton est-il un excellent modèle animal ?Salouci, Moustafa ; Gabriel, Annick in Revue de Médecine Vétérinaire (2016)Les astrocytes représentent la population la plus importante de cellules gliales au sein du système nerveux central (SNC). Leur participation au fonctionnement du système nerveux central et leurs contacts ... [more ▼]Les astrocytes représentent la population la plus importante de cellules gliales au sein du système nerveux central (SNC). Leur participation au fonctionnement du système nerveux central et leurs contacts avec les éléments neuronaux impliquent pour ces cellules des rôles très importants lors du développement du système nerveux, dans le cadre de différentes fonctions vitales et également lors de processus pathologiques. En plus d’être un soutien structurel, ces cellules jouent un rôle dans le métabolisme, la production et la libération de différentes molécules, l'entretien et le remplacement des neurones ; elles assurent également des fonctions immunitaires. La similitude entre l’être humain et le mouton en ce qui concerne certains aspects développementaux et anatomiques a donné de l'importance à ce dernier en tant que modèle expérimental animal permettant de mieux comprendre les rôles joués par les astrocytes dans les processus vitaux et pathologiques. Le but de cet article est de réaliser une synthèse sur le développent et les fonctions des astrocytes et leurs interventions lors de pathologie du SNC chez l’homme et chez le mouton. Enfin, l’utilisation du mouton en tant que modèle animal dans le cadre d’études expérimentales concernant les astrocytes est abordée. [less ▲]Detailed reference viewed: 33 (12 ULg) Comparison of 4 point-of-care blood gas analyzers for arterial blood gas analysis in healthy dogs and dogs with cardiopulmonary diseaseRoels, Elodie ; Gommeren, Kris ; Farnir, Frédéric et alin Journal of Veterinary Emergency and Critical Care (2016), 00(0), 1-8Detailed reference viewed: 22 (3 ULg) What predicts stigmatisation about schizophrenia? Results from a general population survey examining its underlying cognitive, affective and behavioural factorsThonon, Bénédicte ; Larøi, Frank in Psychosis: Psychological, Social and Integrative Approaches (2016)Stigmatisation towards individuals diagnosed with schizophrenia (SZ individuals) remains an important problem, yet few studies to date have examined a theoretically comprehensive set of predictors of ... [more ▼]Stigmatisation towards individuals diagnosed with schizophrenia (SZ individuals) remains an important problem, yet few studies to date have examined a theoretically comprehensive set of predictors of stigmatisation. This study aimed to evaluate cognitive, emotional and behavioural aspects of stigmatisation towards SZ individuals in the Belgian general population in order to better understand its underlying factors. A sample of 544 participants completed online questionnaires assessing common stereotypes regarding schizophrenia, desired social distance, level of contact and the Behaviours from Intergroup Affect and Stereotypes map. Most respondents believed SZ individuals are unpredictable and have a poor prognosis. Around 10% believed that they are dangerous. The most frequently reported emotions were pity and fear. Around 65% of the sample indicated that they would have positive behavioural reactions (passive/active facilitation). Around 33% of the sample indicated that they would distance themselves from SZ individuals, and around 20% would flee if in contact with a SZ individual. Fear and stereotypes of dangerousness and incompetence best predicted these fleeing and avoidance reactions. Fear was also explained by stereotypes of dangerousness and unpredictability. These factors should be accounted for when developing anti-stigma campaigns. The effect of contact should be further investigated. [less ▲]Detailed reference viewed: 25 (2 ULg) Linkages in the Chicken Chain of Vietnam: A Case Study in Kim Dong District, Hung Yen ProvinceBui Thi, Nga; Lebailly, Philippe in International Review of Research in Emerging Markets and the Global Economy (2016), 2(3), 864-872Chicken raising in Kim Dong district, Hung Yen province of Vietnam is currently still in the first stage of development with spontaneous, small-scale, and easily vulnerable. These things lead to the ... [more ▼]Chicken raising in Kim Dong district, Hung Yen province of Vietnam is currently still in the first stage of development with spontaneous, small-scale, and easily vulnerable. These things lead to the inefficiency in the chain activities, and in the long run, all the chain actors will have less benefit. This study aims to analyze and assess the real situation of linkages in the chicken chain and proposed some recommendations to strengthen the linkages and improve the chicken chain in the Kim Dong district based on the questionnaire survey data of chicken chain actors. The findings showed that the chicken chain in the study site was undeveloped. The chain actors included input suppliers, chicken raising farmers, traders, retailers and some restaurants and supermarkets. Farmers accounted for the most important role. The other actors in the chain play a role of a bridge between producers and consumers. Processing agent did not appear in the chain. The linkages in the chain were simple, informal and loose. The actors were discrete and lack of cooperation. To promote the linkage of the chicken chain, farmers should improve their linkages to improve their strength, their voice and their power. Farmers could establish cooperation groups or cooperatives to support each other. Cooperation among chain actors should be enhanced to form a tight and official chain. Local authorities should support in finding markets, creating a bridge and an environment for chain actors. Extension and educational institutions should support farmers and other actors and stakeholders to improve knowledge of the chain, so they could understand the benefit and form effective chain. [less ▲]Detailed reference viewed: 13 (2 ULg) Pratique de l'ostéosynthèse des fractures de jambe en République démocratique du CongoAmisi Kitoko, R.; Asolanyongo, M.K.; Losimba, J.L. et alin Revue de Chirurgie Orthopédique et traumatologique (2016), 102(3), 306-9La prise en charge chirurgicale de la traumatologie à Kisangani (République démocratique du Congo) se heurte à des contraintes médico-économiques et culturelles qui aboutissent souvent à des prises en ... [more ▼]La prise en charge chirurgicale de la traumatologie à Kisangani (République démocratique du Congo) se heurte à des contraintes médico-économiques et culturelles qui aboutissent souvent à des prises en charge retardées. Le but de cette étude était de déterminer les délais de prise en charge, les délais opératoires et de les corréler aux complications postopératoires. Les résultats radiologiques et fonctionnels des fractures de jambe ont été également évalués. Notre hypothèse était que le taux de complications est significativement plus élevé en cas de prise en charge retardée. Cette étude rétrospective a été réalisée aux cliniques universitaires de Kisangani de 1996 à 2009. Soixante-seize fractures de jambe ou du pilon tibial traitées par ostéosynthèse interne ou externe à foyer fermé ou ouvert ont été analysées. Les résultats radiologiques et fonctionnels ont été évalués à 12 mois minimum. La prise en charge des patients était tardive. Le délai moyen d’admission à l’hôpital était de 19 ± 18,28 jours (extrêmes de 1 à 90 jours) avec une différence significative des complications selon le délai d’admission (p < 0,05) aux dépens des patients admis tardivement. Le délai opératoire moyen après l’admission était de 9,5 ± 8,51 jours (extrêmes de 1 à 30 jours) avec une différence significative des complications selon le délai opératoire (p < 0,05) aux dépens des patients opérés tardivement (infections, pseudarthrose). Le délai d’admission ou opératoire n’influençait pas les résultats fonctionnels (p > 0,05). Ces résultats sont cohérents avec ceux rapportés dans la littérature. Le retard de la chirurgie est associé à l’augmentation de complications postopératoires (infection, pseudarthrose) et de la durée d’hospitalisation. Un retard opératoire de plus de 48 heures doit être évité, sauf pour les patients médicalement instables qui nécessitent une période de stabilisation médicale. Niveau de preuve. – Niveau IV : rétrospectif – série historique. [less ▲]Detailed reference viewed: 19 (3 ULg) A framework to identify housing location patterns using profile Hidden Markov ModelsSaadi, Ismaïl ; Liu, Feng; El Saeid Mustafa, Ahmed Mohamed et alin Advanced Science Letters (2016), 22(9), 2117-2121The determination of comprehensive activity-travel patterns is important in the context of agent-based micro-simulation modelling. This paper presents an improved method based on profile Hidden Markov ... [more ▼]The determination of comprehensive activity-travel patterns is important in the context of agent-based micro-simulation modelling. This paper presents an improved method based on profile Hidden Markov Models (pHMMs) able to include information related to the agents’ residential locations. As proposed in the framework of Liu et al. (2015), pHMMs only characterize activity-travel patterns from the activity sequences perspective. In this context, information related to the primary activity locations (e.g. home, work) is not available and, as a result, it cannot be extracted from the pHMMs themselves. With respect to this limitation, we propose to apply the framework of Liu et al. (2015) with an extension to include characterization of residential locations. Following the established guidelines, the activity sequences and their related residential locations are extracted from the activity-travel diaries in order to estimate the regularity of the activities as well as their sequential order. Subsequently, within each residential activity, we include a categorization at an aggregate level (provinces). The methodology is powerful as it characterizes any length of sequence, allowing the generation of unlimited agent plans with information about residential location. Regarding data collection, the activity-travel diaries are provided by the Belgian Household Daily Travel Survey (2010). The results obtained after the simulations indicate a good match between the predicted and observed residential locations at both the national and provincial levels. [less ▲]Detailed reference viewed: 76 (26 ULg) L’utilisation de l’hydrolyse enzymatique pour la production de nanocellulose dans une stratégie de bioraffinage forestier intégré (Synthèse Bibliographique)Bombeck, Pierre-Louis ; Hebert, Jacques ; Richel, Aurore in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(1), 94-103Introduction. In a world that seeks to break free from petrochemicals, the concept of forest biomass biorefinery is increasingly being studied as a way to maximize the value of the components of this ... [more ▼]Introduction. In a world that seeks to break free from petrochemicals, the concept of forest biomass biorefinery is increasingly being studied as a way to maximize the value of the components of this biomass. Due to the high added value expected when transforming cellulose fibers into nanocellulose, this technology is highly attractive to the pulp and paper industrial world.