References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailComparison of clinical effects of epidural levobupivacaine morphine versus bupivacaine morphine in dogs undergoing elective pelvic limb surgery
Cerasoli, Ilaria; Tutunaru, Alexandru-Cosmin ULg; Cenani, Alessia et al

in Veterinary Anaesthesia & Analgesia (2017)

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailDistances between nested densities and a measure of the impact of the prior in Bayesian statistics
Ley, Christophe; Reinert, Gesine; Swan, Yvik ULg

in Annals of Applied Probability (2017), 27(1), 216-241

Detailed reference viewed: 38 (2 ULg)
Full Text
Peer Reviewed
See detailRe-entrant inclusions in cellular solids: From defects to reinforcements
Zorzetto, Laura ULg; Ruffoni, Davide ULg

in Composite Structures (2017), 176

Abstract A contrast in Poisson ratio is a possible strategy to enhance the stiffness of composite structures. In solid materials Poisson ratio is hardly tailorable unless cellular architectures are ... [more ▼]

Abstract A contrast in Poisson ratio is a possible strategy to enhance the stiffness of composite structures. In solid materials Poisson ratio is hardly tailorable unless cellular architectures are considered. Here, we first investigated the effect of a single re-entrant inclusion acting as a defect into a regular (non-re-entrant) honeycomb lattice. Building on this, we generated regular patterns of re-entrant inclusions into a regular hexagonal cellular matrix and we characterized the apparent stiffness and Poisson ratio of the obtained structures. We also explored the role of the intrinsic material properties of the inclusion as well as of its closest environment on the interplay between the deformations of different phases in the lattice. Our main finding is that a small fraction of re-entrant inclusions (around 12%) is sufficient to generate a substantial augmentation in stiffness (300%) at constant overall relative density and without inducing strong anisotropy. Eventually, we fabricated by 3D polyjet printing bi-material composite architectures to demonstrate the superior mechanical behavior obtained exploiting the Poisson effect. [less ▲]

Detailed reference viewed: 55 (15 ULg)
Full Text
Peer Reviewed
See detailL’ÉVALUATION DES POLITIQUES PUBLIQUES DANS LE CHAMP DE LA COOPÉRATION AU DÉVELOPPEMENT BELGE : LE CAS DU SERVICE DE L’ÉVALUATION SPÉCIALE
Contor, Justine ULg

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2017)

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation ... [more ▼]

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation Spéciale de la coopération belge au développement (SES). Nous présenterons dans ce document les raisons de la création de ce service au début des années 2000. En effet, le SES, avec d’autres acteurs, est le résultat d’une grande réforme de la coopération issue d’une lourde crise. Nous reviendrons sur son mandat, sur ses spécificités organisationnelles (ressources financières et humaines) ainsi que son cadre de référence normatif. La question de la culture évaluative sera questionnée, ainsi que son lien avec l’émergence du New Public Management dans la politique de coopération au développement. Enfin, nous questionnerons la légitimité d’une structure telle que le SES au regard d’un cadrage théorique mixte (Scott, 1995 ; Suchmann, 1995) et de la théorie des parties prenantes. [less ▲]

Detailed reference viewed: 51 (13 ULg)
Full Text
Peer Reviewed
See detailPhytotoxic activity and chemical composition of Cassia absus seeds and aerial parts
Zribi, Ines; Sbai, H.; Ghezal, N. et al

in Natural Product Research (2017)

The present study was conducted to assess the phytotoxic potential and the phytochemical composition of Cassia absus. Aqueous extracts caused significant reduction of root growth of Lactuca sativa. Seed ... [more ▼]

The present study was conducted to assess the phytotoxic potential and the phytochemical composition of Cassia absus. Aqueous extracts caused significant reduction of root growth of Lactuca sativa. Seed extract was more effective than aerial part extract. Successive extractions of this plant were performed using solvents with increasing polarities. The methanolic seed extract exerted strong phytotoxic effect on seedling growth, followed by petroleum ether extract of the aerial part. The phytochemical investigation showed that among the organic extracts, methanol extracts of seeds and aerial parts contained the highest amounts of total phenolics and proanthocyanidins. Seeds were rich in linoleic acid followed by palmitic acids. Palmitic, stearic and arachidic acids were the major fatty acids in aerial parts. HPLC-DAD analysis of the methanolic extracts revealed the presence of luteolin in C. absus aerial parts. [less ▲]

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailMaladie coronaire et pratique sportive
ANCION, Arnaud ULg; KAUX, Jean-François ULg; PIERARD, Luc ULg et al

in Revue Médicale de Liège (2017), 72(6), 281-287

Detailed reference viewed: 38 (4 ULg)
Full Text
Peer Reviewed
See detailIntegration of order picking and vehicle routing in a B2C e-commerce context
Moons, Stef; Ramaekers, Katrien; Caris, An et al

in Flexible Services and Manufacturing Journal (2017)

E-commerce sales are increasing every year and customers who buy goods on the Internet have high service level expectations. In order to meet these expectations, a company’s logistics operations need to ... [more ▼]

E-commerce sales are increasing every year and customers who buy goods on the Internet have high service level expectations. In order to meet these expectations, a company’s logistics operations need to be performed carefully. Optimizing only internal warehouse processes will often lead to suboptimal solutions. The interrelationship between the order picking process and the delivery process should not be ignored. Therefore, in this study, an order picking problem and a vehicle routing problem with time windows and release dates are solved simultaneously using a single optimization framework. To the best of our knowledge, it is the first time that an order picking problem and a vehicle routing problem are integrated. A mixed integer linear programming formulation for this integrated order picking-vehicle routing problem (OP-VRP) is provided. The integrated OPVRP is solved for small instances and the results are compared to these of an uncoordinated approach. Computational experiments show that integration can lead to cost savings of 14% on average. Furthermore, higher service levels can be offered by allowing customers to request their orders later and still get delivered within the same time windows. [less ▲]

Detailed reference viewed: 36 (5 ULg)
Full Text
Peer Reviewed
See detailElectrically charged droplets in microgravity
brandenbourger, martin; Caps, Hervé ULg; vitry, youen et al

in Microgravity Science and Technology (2017)

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailAre Th17 Cells Playing a Role in Immunity to Dermatophytosis?
Heinen, Marie-Pierre ULg; Cambier, Ludivine ULg; Fievez, Laurence ULg et al

in Mycopathologia (2017), 182(1), 251-261

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailOccurrence of Clinical Bone Fracture Following a Prolonged Stay in Intensive Care Unit: A Retrospective Controlled Study
ROUSSEAU, Anne-Françoise ULg; CAVALIER, Etienne ULg; Reginster, Jean-Yves ULg et al

in Calcified Tissue International (2017), (Online),

Clinical consequences of critical illness and critical care (CC) on bone health remain largely unexplored. This retrospective study aimed to assess the number of new bone fractures (BF) following a ... [more ▼]

Clinical consequences of critical illness and critical care (CC) on bone health remain largely unexplored. This retrospective study aimed to assess the number of new bone fractures (BF) following a prolonged length of stay (LOS) in intensive care unit (ICU). Adults admitted in our tertiary ICU during 2013 with a stay [7 days were included (CC group). Patients who died in ICU or lost to follow-up were excluded. For each CC patient still alive after 2 years of follow-up, 2 control patients, scheduled for surgery during 2013, were recruited and matched for gender and age. Basal fracture risk before admission was calculated using FRAX tool. General practitioners were phoned to check out new bone fracture (BF) during 2 years after admission. Of the 457 enrolled CC patients, 207 did not meet inclusion criteria and 72 died during FU (median age 72 [65–77] years). New BF occurred in 9 of the 178 patients still alive at the end of FU (5%). Median age of these patients was 64 [53–73] years. Fractured patients did not differ from non-fractured ones based on demographic and clinical characteristics, excepting for FRAX risks that were higher in fractured patients. In the control group, 327 patients were analyzed. Their rate of BF was 3.4% without statistical significance compared to the CC group. FRAX risks were similar in both groups. The risk of new BF in CC group, expressed as an odds ratio, was 50% higher than in the control group without achieving statistical significance (odds ratio 1.53; 95% confidence interval 0.62–3.77; p = 0.35). When comparing ICU survivors to patients who underwent uncomplicated surgery in the present preliminary study included limited cohorts, the fracture risk in the 2 years following prolonged ICU stay was not statistically higher. However, CC fractured patients had higher FRAX risks than non-fractured patients. Such screening could help to target prevention and appropriate treatment strategies. [less ▲]

Full Text
Peer Reviewed
See detailPharmacotherapy of 'treatment resistant' type 2 diabetes.
Scheen, André ULg

in Expert Opinion on Pharmacotherapy (2017), 1

INTRODUCTION: Despite type 2 diabetes (T2D) management offers a variety of pharmacological interventions targeting different defects, numerous patients remain with persistent hyperglycaemia responsible ... [more ▼]

INTRODUCTION: Despite type 2 diabetes (T2D) management offers a variety of pharmacological interventions targeting different defects, numerous patients remain with persistent hyperglycaemia responsible for severe complications. Unlike resistant hypertension, treatment resistant T2D is not a classical concept although it is a rather common observation in clinical practice. Areas covered: This article proposes a definition for 'treatment resistant diabetes', analyses the causes of poor glucose control despite standard therapy, briefly considers the alternative approaches to glucose-lowering pharmacotherapy and finally describes how to overcome poor glycaemic control, using innovative oral or injectable combination therapies. Expert opinion: Before considering intensifying the pharmacotherapy of a patient with poorly controlled T2D, it is important to verify treatment adherence, target obesity and consider various non pharmacological improvement quality interventions. If treatment resistant diabetes is defined as not achieving glycated haemoglobin target despite oral triple therapy with a third glucose-lowering agent added to metformin-sulfonylurea dual treatment, the combination of a dipeptidyl peptidase-4 (DPP-4) inhibitor and a sodium glucose cotransporter type 2 (SGLT2) inhibitor may offer new opportunities before considering injectable therapies. Insulin basal therapy (+/- metformin) may be optimized by the addition of a SGLT2 inhibitor or a glucagon-like peptide-1 (GLP-1) receptor agonist. [less ▲]

Detailed reference viewed: 35 (3 ULg)
Full Text
Peer Reviewed
See detailAgro-physiological and biochemical responses of faba bean (Vicia faba L. var. 'minor') genotypes to water deficit stress
Abid, Ghassen; Hessini, Kamel; Aouida, Marwa et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21(2),

Drought is one of the major abiotic factors affecting growth and productivity of plants by imposing certain morphological, physiological and biochemical changes at different growth stages. The objective ... [more ▼]

Drought is one of the major abiotic factors affecting growth and productivity of plants by imposing certain morphological, physiological and biochemical changes at different growth stages. The objective of this work is to study key morphological, physiological and biochemical response of faba bean (Vicia faba L. var. 'minor') to soil water deficit stress and to assess the contribution of genetic factors in improving faba bean tolerance to water deficit. Plant of 11 faba bean cultivars were grown in the greenhouse and subjected to three levels of water deficit (90, 50 and 30% of field capacity (FC)) in a simple randomized design for 20 days. Water deficit effects on plant growth, relative water content (RWC), gaz exchange, chlorophyll a (Chla) and Chlorophyll b (Chlb) content, osmoprotectant accumulations (such as proline and soluble sugars), antioxydant enzyme activities and grain yield were determined. Soil water deficit stress reduced growth and affected physiological parameters, especially antioxidant enzyme activities. Water deficit also increased proline, soluble sugars and protein contents. The studied cultivars significantly differed in their responses to water deficit stress. Photosynthetic parameters were less affected in the 'Hara' cultivar. Furthermore, this cultivar produced the highest value of grain yield at 30% FC, and showed higher antioxidant enzyme activities (CAT, GPX and APX), osmoprotectant accumulations, Chlb and RWC. The 'Hara' cultivar was found to be more tolerant to water deficit stress than the other cultivars. Our methodology can be used for assessing the response of faba bean genetic resources to soil water deficit. The identified tolerant cultivar can be utilized as a source for water stress tolerance in faba bean breeding programs aimed at improving drought tolerance. [less ▲]

Detailed reference viewed: 50 (1 ULg)
Full Text
Peer Reviewed
See detailPreterm Infant Growth Velocity Calculations: A Systematic Review
Fenton, Tanis; Chan, Hilton; Madhu, Aiswarya et al

in Pediatrics (2017), 139(3), 1-10

Detailed reference viewed: 44 (2 ULg)
Full Text
Peer Reviewed
See detailUncertain altruism and the provision of long term care
Cremer, Helmuth; Gahvari, Firouz; Pestieau, Pierre ULg

in Journal of Public Economics (2017), 151

Detailed reference viewed: 16 (3 ULg)
Full Text
Peer Reviewed
See detailTrace element concentrations in the apex predator swordfish (Xiphias gladius) from a Mediterranean fishery and risk assessment for consumers
Gobert, Sylvie ULg; Pasqualini, Vanina; Dijoux, Jessica et al

in Marine Pollution Bulletin (2017), 120

Swordfish (Xiphias gladius L., 1758) is an apex predator, highly migratory meso-pelagic fish widely distributed in the Atlantic Ocean and Mediterranean. As top predators, this fish may be the end ... [more ▼]

Swordfish (Xiphias gladius L., 1758) is an apex predator, highly migratory meso-pelagic fish widely distributed in the Atlantic Ocean and Mediterranean. As top predators, this fish may be the end reservoir of the bioaccumulation of trace elements in a food chain because they occupy higher trophic levels and are an important food source, causing them to be potentially hazardous to consume. This study aims to investigate the concentration of 18 trace elements of Swordfish, caught in the Mediterranean Sea and to discuss human exposure risks. The mean element levels in the fish muscles were clearly below the maximum allowable concentrations established by International food safety regulations. The data suggested that the risk is minor and acceptable for human health. The findings of this study amplify the scarce database on contaminants available, especially new data on “emerging elements”, for this species from the Mediterranean Sea. [less ▲]

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailThe role of fatty acid beta-oxidation in lymphangiogenesis.
Wong, Brian W.; Wang, Xingwu; Zecchin, Annalisa et al

in Nature (2017), 542(49),

Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in ... [more ▼]

Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in transgenic mouse models, LEC-specific loss of CPT1A, a rate-controlling enzyme in fatty acid beta-oxidation, impairs lymphatic development. LECs use fatty acid beta-oxidation to proliferate and for epigenetic regulation of lymphatic marker expression during LEC differentiation. Mechanistically, the transcription factor PROX1 upregulates CPT1A expression, which increases acetyl coenzyme A production dependent on fatty acid beta-oxidation. Acetyl coenzyme A is used by the histone acetyltransferase p300 to acetylate histones at lymphangiogenic genes. PROX1-p300 interaction facilitates preferential histone acetylation at PROX1-target genes. Through this metabolism-dependent mechanism, PROX1 mediates epigenetic changes that promote lymphangiogenesis. Notably, blockade of CPT1 enzymes inhibits injury-induced lymphangiogenesis, and replenishing acetyl coenzyme A by supplementing acetate rescues this process in vivo. [less ▲]

Detailed reference viewed: 49 (5 ULg)
Full Text
Peer Reviewed
See detailComparative Genomic Analysis Reveals Ecological Differentiation in the Genus Carnobacterium.
Iskandar, Christelle F.; Borges, Frederic; Taminiau, Bernard ULg et al

in Frontiers in Microbiology (2017), 8

Lactic acid bacteria (LAB) differ in their ability to colonize food and animal-associated habitats: while some species are specialized and colonize a limited number of habitats, other are generalist and ... [more ▼]

Lactic acid bacteria (LAB) differ in their ability to colonize food and animal-associated habitats: while some species are specialized and colonize a limited number of habitats, other are generalist and are able to colonize multiple animal-linked habitats. In the current study, Carnobacterium was used as a model genus to elucidate the genetic basis of these colonization differences. Analyses of 16S rRNA gene meta-barcoding data showed that C. maltaromaticum followed by C. divergens are the most prevalent species in foods derived from animals (meat, fish, dairy products), and in the gut. According to phylogenetic analyses, these two animal-adapted species belong to one of two deeply branched lineages. The second lineage contains species isolated from habitats where contact with animal is rare. Genome analyses revealed that members of the animal-adapted lineage harbor a larger secretome than members of the other lineage. The predicted cell-surface proteome is highly diversified in C. maltaromaticum and C. divergens with genes involved in adaptation to the animal milieu such as those encoding biopolymer hydrolytic enzymes, a heme uptake system, and biopolymer-binding adhesins. These species also exhibit genes for gut adaptation and respiration. In contrast, Carnobacterium species belonging to the second lineage encode a poorly diversified cell-surface proteome, lack genes for gut adaptation and are unable to respire. These results shed light on the important genomics traits required for adaptation to animal-linked habitats in generalist Carnobacterium. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailMetabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach
Govinden-Soulange, J.; Lobine, D.; Frederich, Michel ULg et al

in South African Journal of Botany (2017), 108

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect ... [more ▼]

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. Nuclear magnetic resonance spectroscopy, DNA sequencing and antioxidant profiles of these Aloes were studied. Principal component analysis following 1H NMR revealed the specificity of the Mascarene Aloes relative to Aloe vera. The superior free radical scavenging ability of A. purpurea, A. macra and A. tormentorii as compared to other Aloes was also unveiled. Phylogenetic analyses of chloroplast genes and ITS region sequences of these Mascarene Aloes were done using maximum parsimony and Bayesian analysis. Mascarene Aloes clustered within one clade separate from Aloe vera confirming their relative recent emergence in this genus. Results from this study showed that there is sufficient evidence at the metabolomic and molecular level to distinguish between Aloe ​purpurea from Mauritius and that of Reunion. © 2016 SAAB [less ▲]

Detailed reference viewed: 35 (2 ULg)
Full Text
Peer Reviewed
See detailTwo-Parameter Kinematic Approach for Shear Strength of Deep Concrete Beams with Internal FRP Reinforcement
Mihaylov, Boyan ULg

in Journal of Composites for Construction (2017), DOI: 10.1061/(ASCE)CC.1943-5614 .0000747

Tests of deep concrete beams with internal fiber-reinforced polymer (FRP) reinforcement have shown that such members can exhibit lower shear strength than members with conventional steel reinforcement. To ... [more ▼]

Tests of deep concrete beams with internal fiber-reinforced polymer (FRP) reinforcement have shown that such members can exhibit lower shear strength than members with conventional steel reinforcement. To model this effect, the current paper proposes an approach based on a two-parameter kinematic theory (2PKT) for conventional deep beams. The 2PKT is built on a kinematic model with two degrees of freedom that describes the deformation patterns of cracked beams. Using this theory shows that large strains in FRP longitudinal reinforcement result in reduced shear resistance of the critical loading zones (CLZ) of deep beams. The original 2PKT is therefore modified by introducing a reduction factor for the shear carried by the CLZ. The extended 2PKT approach is then applied to a database of 39 tests of FRP-reinforced deep beams from the literature, resulting in an average shear strength experimental-to-predicted ratio of 1.06 and a coefficient of variation of 18.3%. The results show that the 2PKT adequately captures the effects of the stiffness of the reinforcement, section depth, concrete strength, and shear-span-to-depth ratio on the shear strength of FRP-reinforced deep beams. [less ▲]

Detailed reference viewed: 34 (17 ULg)
Full Text
Peer Reviewed
See detailVariable thickness scroll compressor performance analysis—Part II: Dynamic modeling and model validation
Bin, Peng; Lemort, Vincent ULg; Legros, Arnaud et al

in Proc IMechE Part E: J Process Mechanical Engineering (2017)

In order to investigate the performance of variable thickness scroll compressor, a detail mathematical modeling based on energy and mass balances is established in this two-part. In part II, dynamic ... [more ▼]

In order to investigate the performance of variable thickness scroll compressor, a detail mathematical modeling based on energy and mass balances is established in this two-part. In part II, dynamic modeling and model validation are developed. Temperature, pressure, mass flow of working chambers, friction loss power of moving parts, efficiency, and shaft power are investigated by solving the mathematical modeling. The experimental rig for variable thickness scroll compressor based on involute of circle, high order curve and arc is set up. From the comparison of the simulated and measured data, it can be seen that the compressor model predicts the mass flow, discharge temperature, and shaft power very well. So the proposed mathematical modeling can accurately describe all the suction, compression, and discharge processes for variable thickness scroll compressor. [less ▲]

Detailed reference viewed: 36 (2 ULg)
Full Text
Peer Reviewed
See detailThe proteolytic system of pineapple stems revisited: Purification and characterization of multiple catalytically active forms.
Matagne, André ULg; Bolle, Laetitia; El Mahyaoui, Rachida et al

in Phytochemistry (2017), (138), 29-51

Crude pineapple proteases extract (aka stem bromelain; EC 3.4.22.4) is an important proteolytic mixture that contains enzymes belonging to the cysteine proteases of the papain family. Numerous studies ... [more ▼]

Crude pineapple proteases extract (aka stem bromelain; EC 3.4.22.4) is an important proteolytic mixture that contains enzymes belonging to the cysteine proteases of the papain family. Numerous studies have been reported aiming at the fractionation and characterization of the many molecular species present in the extract, but more efforts are still required to obtain sufficient quantities of the various purified protease forms for detailed physicochemical, enzymatic and structural characterization. In this work, we describe an efficient strategy towards the purification of at least eight enzymatic forms. Thus, following rapid fractionation on a SP-Sepharose FF column, two sub-populations with proteolytic activity were obtained: the unbound (termed acidic) and bound (termed basic) bromelain fractions. Following reversible modification with monomethoxypolyethylene glycol (mPEG), both fractions were further separated on Q-Sepharose FF and SP-Sepharose FF, respectively. This procedure yielded highly purified molecular species, all titrating ca. 1 mol of thiol group per mole of enzyme, with distinct biochemical properties. N-terminal sequencing allowed identifying at least eight forms with proteolytic activity. The basic fraction contained previously identified species, i.e. basic bromelain forms 1 and 2, ananain forms 1 and 2, and comosain (MEROPS identifier: C01.027). Furthermore, a new proteolytic species, showing similarities with basic bomelain forms 1 and 2, was discovered and termed bromelain form 3. The two remaining species were found in the acidic bromelain fraction and were arbitrarily named acidic bromelain forms 1 and 2. Both, acidic bromelain forms 1, 2 and basic bromelain forms 1, 2 and 3 are glycosylated, while ananain forms 1 and 2, and comosain are not. The eight protease forms display different amidase activities against the various substrates tested, namely small synthetic chromogenic compounds (DL-BAPNA and Boc-Ala-Ala-Gly-pNA), fluorogenic compounds (like Boc-Gln-Ala-Arg-AMC, Z-Arg-Arg-AMC and Z-Phe-Arg-AMC), and proteins (azocasein and azoalbumin), suggesting a specific organization of their catalytic residues. All forms are completely inhibited by specific cysteine and cysteine/serine protease inhibitors, but not by specific serine and aspartic protease inhibitors, with the sole exception of pepstatin A that significantly affects acidic bromelain forms 1 and 2. For all eight protease forms, inhibition is also observed with 1,10-phenanthrolin, a metalloprotease inhibitor. Metal ions (i.e. Mn2+, Mg2+ and Ca2+) showed various effects depending on the protease under consideration, but all of them are totally inhibited in the presence of Zn2+. Mass spectrometry analyses revealed that all forms have a molecular mass of ca. 24 kDa, which is characteristic of enzymes belonging to the papain-like proteases family. Far-UV CD spectra analysis further supported this analysis. Interestingly, secondary structure calculation proves to be highly reproducible for all cysteine proteases of the papain family tested so far (this work; see also Azarkan et al., 2011; Baeyens-Volant et al., 2015) and thus can be used as a test for rapid identification of the classical papain fold. [less ▲]

Detailed reference viewed: 24 (4 ULg)
Full Text
Peer Reviewed
See detailOn the equality between two diametral dimensions
Bastin, Françoise ULg; Demeulenaere, Loïc ULg

in Functiones et Approximatio Commentarii Mathematici (2017), 56(1), 95-107

Detailed reference viewed: 127 (61 ULg)
Full Text
Peer Reviewed
See detailGlioblastoma stem cells and the importance of endolysosomes to keep them in the niches
Rogister, Bernard ULg

in Translational Cancer Research (2017), 6(Suppl 1), 87-89

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailUbiquité et situation : Pour une considération topologique de la limite
Englebert, Jérôme ULg

in Le Cercle herméneutique (2017), 28

Detailed reference viewed: 50 (2 ULg)
Full Text
Peer Reviewed
See detailA French version of the Balanced Time Perspective Scale: Factor structure and relation to cognitive reappraisal.
Barsics, Catherine ULg; Rebetez, Marie; Rochat, Lucien et al

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2017), 49(1), 51-57

A frequent and equal tendency to think positively about one’s past and future has been conceptualised as a balanced time perspective (TP). Such a dispositional temporal orientation has been associated ... [more ▼]

A frequent and equal tendency to think positively about one’s past and future has been conceptualised as a balanced time perspective (TP). Such a dispositional temporal orientation has been associated with higher life satisfaction and happiness. The aim of the present study was to develop and to validate a French version of the Balanced Time Perspective Scale (BTPS; Webster, 2011), which has been specifically designed to assess the combined use of positive future and past mental representations as resources for the self. Data were collected from an online survey in a sample of 622 French-speaking individuals from the general population. Results indicated that the French version of the BTPS replicated the 2-factor structure of the original questionnaire, and showed excellent internal consistency. External validity was supported by specific rela- tionships with measures of TP and positive affect. In addition, a high propensity to project oneself positively both in the future and the past was associated with greater use of cognitive reappraisal. [less ▲]

Detailed reference viewed: 40 (0 ULg)
Full Text
Peer Reviewed
See detailEvidence for a latitudinal diversity gradient in liverworts and hornworts
Wang, J.; Vanderpoorten, Alain ULg; Hagborg, A. et al

in Journal of Biogeography (2017), 44

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailLooking beyond general metrics for model comparison – lessons from an international model intercomparison study
de Boer-Euser, Tanja; Bouaziz, Laurène; De Niel, Jan et al

in Hydrology and Earth System Sciences (2017), 21

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for ... [more ▼]

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for international cooperation, they do often not lead to very clear new insights regarding the relevance of the modelled processes. We hypothesise that this is partly caused by model complexity and the comparison methods used, which focus too much on a good overall performance instead of focusing on specific events. In this study, we use an approach that focuses on the evaluation of specific events and characteristics. Eight international research groups calibrated their hourly model on the Ourthe catchment in Belgium and carried out a validation in time for the Ourthe catchment and a validation in space for nested and neighbouring catchments. The same protocol was followed for each model and an ensemble of best performing parameter sets was selected. Although the models showed similar performances based on general metrics (i.e. Nash–Sutcliffe Efficiency), clear differences could be observed for specific events. The results illustrate the relevance of including a very quick flow reservoir preceding the root zone storage to model peaks during low flows and including a slow reservoir in parallel with the fast reservoir to model the recession for the Ourthe catchment. This intercomparison enhanced the understanding of the hydrological functioning of the catchment and, above all, helped to evaluate each model against a set of alternative models. [less ▲]

Detailed reference viewed: 44 (2 ULg)
Full Text
Peer Reviewed
See detailA (re)investigation of Middle Kingdom speech captions in wrestling scenes
Motte, Aurore ULg

in Journal of Egyptian Archaeology (2017), 103(1),

This paper studies the Reden und Rufe present in Middle Kingdom wrestling scenes found in the tombs of Senbi (Meir), Neheri I (Deir el-Bersha), and Khety (Beni Hassan). Based on a systematic study, some ... [more ▼]

This paper studies the Reden und Rufe present in Middle Kingdom wrestling scenes found in the tombs of Senbi (Meir), Neheri I (Deir el-Bersha), and Khety (Beni Hassan). Based on a systematic study, some improvements are suggested to previous translations. After offering commentaries and translation(s) for each speech, the relationship between these scenes and those in Old Kingdom tombs is considered, and distinctive features highlighted. [less ▲]

Detailed reference viewed: 33 (2 ULg)
Full Text
Peer Reviewed
See detailEvidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
Hinney, A.; Kesselmeier, M.; Jall, S. et al

in Molecular Psychiatry (2017), 22(2), 192-201

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range ... [more ▼]

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 x 10-5, Bonferroni-corrected P<0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; Poverall: 2.47 x 10-06/Pfemales: 3.45 x 10-07/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailCorrelations Between Cloud Point and Compositional Properties of Palm Oil and Liquid Fractions from Dry Fractionation
Danthine, Sabine ULg; Lefebure, Emilie; Blecker, Christophe ULg et al

in Journal of the American Oil Chemists' Society (2017), 94(6), 841-853

Dry fractionation of palm oil can be conducted as a multi-step process; this gives rise to new softer and harder fractions having multitudes of applications in fat foods. This work focuses on the liquid ... [more ▼]

Dry fractionation of palm oil can be conducted as a multi-step process; this gives rise to new softer and harder fractions having multitudes of applications in fat foods. This work focuses on the liquid fractions obtained following a triple-step fractionation; the cloud point was measured on a set of 125 palm oil, olein, super olein and top olein samples, with the intention to correlate this value to the compositional properties. The Mettler cloud point, the diacylglycerol content, some selected single or groups of triacylglycerols and the iodine value (in total, 11 variables per sample) were measured and entered in a statistical model. A principal component analysis (PCA) was first carried out from which different sub-groups were highlighted. In each sub-group, various regressions (simple linear, simple non-linear and multiple linear) were applied and 28 significant equations were derived. Out of these, one multiple linear regression involving the iodine value, the UUU and PPP contents showed the best correlation with the Mettler cloud point. This equation was selected to predict the cloud point since it was further successfully validated by using a set of 25 other independent samples. A partial least square (PLS) regression was tested and also considered adequate to predict the cloud point. [less ▲]

Detailed reference viewed: 25 (1 ULg)
Full Text
Peer Reviewed
See detailCarbon budget measurement over 12 years at a crop production site in the silty-loam region in Belgium
Buysse, Pauline; Bodson, Bernard ULg; Debacq, Alain ULg et al

in Agricultural and Forest Meteorology (2017), 246

Carbon dioxide (CO2) exchanges between crops and the atmosphere are influenced by both climatic and management drivers. In this study, a site at the Lonzée Terrestrial Observatory (candidate ICOS site) in ... [more ▼]

Carbon dioxide (CO2) exchanges between crops and the atmosphere are influenced by both climatic and management drivers. In this study, a site at the Lonzée Terrestrial Observatory (candidate ICOS site) in Belgium that had been managed for more than 70 years using conventional farming practices, was monitored over three complete rotation cycles (sugar beet/winter wheat/seed potato/winter wheat) from 2004 to 2016. Continuous eddy-covariance measurements and regular biomass samplings were performed in order to obtain the daily and seasonal Net Ecosystem Exchange (NEE), Gross Primary Productivity (GPP), Total Ecosystem Respiration (TER), Net Primary Productivity (NPP) and Net Biome Production (NBP). Meteorological data and crop management practices were also recorded. Over the 12 crop seasons, total NEE varied both between and within crop types. Crop type influenced net carbon (C) sequestration, with the seed potato crop exhibiting the smallest C fluxes. Despite differences in CO2 assimilation response to weather variables and in cumulated TER/GPP dynamics, the sugar beet, winter wheat and maize crops had similar seasonal NEE values. The NEE inter-annual variability, both between and within crop types, was explained mainly by the length of the active vegetation period, as well as the cumulated photosynthetic photon flux density and average air temperature during this period. The establishment of the C budget over the 12 years of study showed that NEE was a downward (negative) flux (−4.40 ± 0.05 kg C m−2), but NBP was an upward (positive) flux (0.99 ± 0.22 kg C m−2). That is, as soon as C exportation at harvest and C importation (manure, slimes) were included in the budget, the site behaved as a C source. The intercrop periods contributed significantly to the total C budget, and the C fluxes generated during these periods were positively related to crop residue amount and temperature. The largest uncertainties about the crop C budget were those relating to biomass measurements. Carrying out a soil C inventory would help to validate the NBP-based estimate of soil C loss. [less ▲]

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailAge-dependent reference intervals for estimated and measured glomerular filtration rate
Pottel, Hans; DELANAYE, Pierre ULg; WEEKERS, Laurent ULg et al

in Clinical Kidney Journal (2017), 10(4), 545-551

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailA multivariable prediction model for pegvisomant dosing: monotherapy and in combination with long-acting somatostatin analogues
Franck, Sanne Elisabeth; Korevaar, Tim; PETROSSIANS, Patrick ULg et al

in European Journal of Endocrinology (2017)

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and ... [more ▼]

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. Objective: To identify predictors of the PEGV dose required to normalize insulin-like growth factor I (IGF-I) levels during PEGV monotherapy and in combination with long-acting somatostatin analogues (LA-SSAs). 188) were meta-analysed as a form of external replication to study the predictors of PEGV dosing in addition to LA-SSA, the LAS (n=83) was used to study the predictors of PEGV monotherapy dosing. Multivariable regression models were used to identify predictors of the PEGV dose required to normalize IGF-I levels. <0.001, p=<0.001, p=0.028 and p=0.047, respectively). Taken together, these characteristics predicted the PEGV normalization dose correctly in 63.3% of all patients within a range of +/- 60 mg/week (21.3% within a range of +/- 20 mg/week). For monotherapy, only weight was associated with the PEGV normalization dose (p=<0.001) and predicted this dosage correctly in 77.1% of all patients within a range of +/- 60 mg/week (31.3% within a range of +/- 20 mg/week). Conclusion: In this study, we show that IGF-I levels, weight, height and age can contribute to define the optimal PEGV dose in order to normalize IGF-I levels in addition to LA-SSA. For PEGV monotherapy, only the patient's weight was associated with the IGF-I normalization PEGV dosage. [less ▲]

Detailed reference viewed: 34 (6 ULg)
Full Text
Peer Reviewed
See detailEvaluation of the spatial and economic effectiveness of industrial land policies in Northwest Europe
Vandermeer, Marie-Caroline; Halleux, Jean-Marie ULg

in European Planning Studies (2017)

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e ... [more ▼]

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e. that industrial land policy plays a key role in the creation of growth and new jobs. The article begins with a reflection on the literature, which stresses the need to develop knowledge on industrial land policies. To help fill this research gap, we have developed an exploratory piece of research on the theme of their spatial and economic effectiveness, on the basis of statistical analyses dedicated to seven countries. As regards spatial effectiveness, the results underline significant national differentials in terms of land consumption on the one hand, while highlighting the economic sprawl that affects France and Belgium on the other hand. As regards economic effectiveness, our results show that the impact of the development of economic estates on growth depends largely on regional contexts. In particular, the “intermediate regions” in western Germany stand out as belonging to a specific context where land policies seem particularly effective from an economic standpoint. By contrast, the economic effectiveness of industrial land policies requires readjustments in most “predominantly rural regions, close to a city”. [less ▲]

Detailed reference viewed: 38 (11 ULg)
Full Text
Peer Reviewed
See detailThe three-dimensional rectangular Multiple Bin Size Bin Packing Problem with transportation constraints: A case study in the field of air transportation
Paquay, Célia ULg

in 4OR : Quarterly Journal of the Belgian, French and Italian Operations Research Societies (2017)

Ph. D Thesis summary see other reference on ORBI

Detailed reference viewed: 31 (0 ULg)
Full Text
Peer Reviewed
See detailUmbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukemia
Nikolajeva, Olga; Rocha, Vanderson; Danby, Robert et al

in Biology of Blood and Marrow Transplantation (2017)

Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are ... [more ▼]

Several studies have reported an impact of adult hematopoietic stem cell donor cytomegalovirus (CMV) serostatus on allogeneic hematopoietic cell transplantation outcomes. Limited data, however, are available on the impact of cord blood unit (CBU) CMV serostatus on allogeneic umbilical cord blood transplantation (UCBT) outcomes. We analyzed, retrospectively, the impact of CBU CMV serostatus on relapse incidence (RI) and 2-year nonrelapse mortality (NRM) of single-unit CBU transplantation for acute leukemia. Data from 1177 de novo acute leukemia pediatric and adult patients transplanted within European Group for Blood and Marrow Transplantation centers between 2000 and 2012 were analyzed. CBUs were provided by the European Cord Blood Banks. The median follow-up time for live patients was 59.9 months. The recipients of CMV-seropositive and -seronegative CBUs showed a comparable RI (33% versus 35%, respectively, P = .6) and 2-year cumulative incidence of NRM (31% versus 32%, respectively, P = .5). We conclude that CBU CMV serostatus did not influence RI and NRM in de novo acute leukemia patients after allo-UCBT and should not be included as a criteria for cord blood choice. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailObservations of asymmetric turbulent stirring in inner and marginal seas using satellite imagery
Karimova, Svetlana ULg

in International Journal of Remote Sensing (2017), 38(6), 1642-1664

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale ... [more ▼]

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale cyclonic and anticyclonic eddies in a number of inner and marginal marine basins, namely in the Baltic, Black, North, and Western Mediterranean Seas. As research material, over 9700 eddy manifestations in the thermal infrared, visible-range, and radar satellite imagery were used. The analysis performed showed that in all the seas the typical and average values of the diameter of anticyclonic eddies were greater than those of cyclonic eddies. The main factor that defines the ratio between anticyclonic and cyclonic eddies in the basins under consideration was discovered to be the intensity of their surface currents. Thus, in the presence of a strong jet flow at the scales of about 2–4 baroclinic Rossby radii the cyclonic eddy dominance typical for smaller eddies was replaced by the anticyclonic one. If strong jet streams were missing, as that typical of the Baltic Sea, cyclonic eddies were prevailing over the entire spectrum of eddy diameters. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailMixed surfactant systems of sucrose esters and lecithin as a synergistic approach for oil structuring
Bin Sintang, M Dona; Danthine, Sabine ULg; Patel, Ashok R et al

in Journal of Colloid and Interface Science (2017), 504

In order to modify the self-assembly of sucrose esters (SEs) in sunflower oil, we added sunflower lecithin (SFL) as co-surfactant. It is hypothesized that SFL modifies the selfassembly of SEs by ... [more ▼]

In order to modify the self-assembly of sucrose esters (SEs) in sunflower oil, we added sunflower lecithin (SFL) as co-surfactant. It is hypothesized that SFL modifies the selfassembly of SEs by interrupting the extensive hydrogen bonding between SEs monomers. The addition of SFL into SEs induced gelation of the mixed surfactant system oleogels at all studied ratios. The 7:3 SEs:SFL combination showed enhanced rheological properties compared to the other studied ratios, which suggests better molecular ordering induced by SFL. The modifications might have been caused by interference in the hydrogen bonding, connecting the polar heads of SEs molecules in the presence of SFL. This effect was confirmed by thermal behavior and small angle x-ray diffraction (SAXD) analysis. From the crystallization and melting analyses, it was shown that the peak temperature, shape and enthalpy decreased as the SFL ratio increases. Meanwhile, the bi-component oleogels exhibited new peaks in the SAXD profile, which imply a self-assembly modification. The microscopic study through polarized and electrons revealed a change in the structure. Therefore, it can be concluded that a synergistic effect between SEs and SFL, more particularly at 7:3 ratio, towards sunflower oil structuring could be obtained. These findings shed light for greater applications of SEs as structuring and carrier agent in foods and pharmaceutical. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailRetos actuales en la caracterización de los flujos agua-aire en grandes obras hidráulicas
Valero Huerta, Daniel ULg

in REVISTA HIDROLATINOAMERICANA (2017), 1

Present literature on air-water flows is briefly reviewed, including articles of the main five international Journals published along the last four years. Main advances in the most fruitful topics related ... [more ▼]

Present literature on air-water flows is briefly reviewed, including articles of the main five international Journals published along the last four years. Main advances in the most fruitful topics related to air entrainment are discussed. Main areas of interest are: stepped spillways, bubbles in pipe flows, numerical modelling and instrumentation. [less ▲]

Detailed reference viewed: 29 (1 ULg)
Full Text
Peer Reviewed
See detailQuand la rue kinoise envahit le politique...
Polet, François ULg

in Cahiers Africains (2017), 94

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailMacroevolution of Specificity in Cyanolichens of the Genus Peltigera Section Polydactylon (Lecanoromycetes, Ascomycota)
Magain, Nicolas ULg; Miadlikoswka, Jolanta; Goffinet, Bernard et al

in Systematic Biology (2017), 66(1), 74-99

Detailed reference viewed: 27 (5 ULg)
Full Text
Peer Reviewed
See detailDonnées nouvelles sur quelques espèces minérales de Haut-le-Wastia (Province de Namur, Belgique)
Blondieau, M; Puccio, S; Compère, Philippe ULg et al

in Bulletin de la Société Royale des Sciences de Liège (2017), 86

Detailed reference viewed: 8 (4 ULg)
Full Text
Peer Reviewed
See detailSpecial issue on Caryl Phillips
Ledent, Bénédicte ULg

in Ariel : A Review of International English Literature (2017), 48(3&4), 1-247

Detailed reference viewed: 35 (8 ULg)
Full Text
Peer Reviewed
See detailLaBGen: A method based on motion detection for generating the background of a scene
Laugraud, Benjamin ULg; Pierard, Sébastien ULg; Van Droogenbroeck, Marc ULg

in Pattern Recognition Letters (2017), 96

Given a video sequence acquired with a fixed camera, the generation of the stationary background of the scene is a challenging problem which aims at computing a reference image for a motionless background ... [more ▼]

Given a video sequence acquired with a fixed camera, the generation of the stationary background of the scene is a challenging problem which aims at computing a reference image for a motionless background. For that purpose, we developed our method named LaBGen, which emerged as the best one during the Scene Background Modeling and Initialization (SBMI) workshop organized in 2015, and the IEEE Scene Background Modeling Contest (SBMC) organized in 2016. LaBGen combines a pixel-wise temporal median filter and a patch selection mechanism based on motion detection. To detect motion, a background subtraction algorithm decides, for each frame, which pixels belong to the background. In this paper, we describe the LaBGen method extensively, evaluate it on the SBI 2016 dataset and compare its performance with other background generation methods. We also study its computational complexity, the performance sensitivity with respect to its parameters, and the stability of the predicted background image over time with respect to the chosen background subtraction algorithm. We provide an open source C++ implementation at http://www.telecom.ulg.ac.be/labgen. [less ▲]

Detailed reference viewed: 238 (67 ULg)
Full Text
Peer Reviewed
See detailOrigine et histoire de la folie : un nouveau Foucault, un nouveau fou
Englebert, Jérôme ULg

in Evolution Psychiatrique (2017), 82(2), 436-437

Detailed reference viewed: 61 (6 ULg)
Full Text
Peer Reviewed
See detailLand use change affects biogenic silica pool distribution in a subtropical soil toposequence
Unzue-Belmonte, Dacil; Ameijeiras-Marino, Yolanda; Opfergelt, Sophie et al

in Solid Earth (2017)

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailModeling pre-metastatic lymphvascular niche in the mouse ear sponge assay.
Garcia-Caballero, Melissa; Van De Velde, Maureen ULg; Blacher, Silvia ULg et al

in Scientific Reports (2017), 7

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental ... [more ▼]

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental for investigating alterations occurring in lymph nodes before tumor cell arrival. In this study, we demonstrate that B16F10 melanoma cell encapsulation in a biomaterial, and implantation in the mouse ear, prevents their rapid lymphatic spread observed when cells are directly injected in the ear. Vascular remodeling in lymph nodes was detected two weeks after sponge implantation, while their colonization by tumor cells occurred two weeks later. In this model, a huge lymphangiogenic response was induced in primary tumors and in pre-metastatic and metastatic lymph nodes. In control lymph nodes, lymphatic vessels were confined to the cortex. In contrast, an enlargement and expansion of lymphatic vessels towards paracortical and medullar areas occurred in pre-metastatic lymph nodes. We designed an original computerized-assisted quantification method to examine the lymphatic vessel structure and the spatial distribution. This new reliable and accurate model is suitable for in vivo studies of lymphangiogenesis, holds promise for unraveling the mechanisms underlying lymphatic metastases and pre-metastatic niche formation in lymph nodes, and will provide new tools for drug testing. [less ▲]

Detailed reference viewed: 28 (15 ULg)
Full Text
Peer Reviewed
See detailRe: Prediction of delivery time in second stage of labor using transperineal ultrasound.
Tutschek, B.; Braun, T.; CHANTRAINE, Frédéric ULg et al

in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017), 49(5), 663-664

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailMembrane Interactions of Natural Cyclic Lipodepsipeptides of the Viscosin Group
Geudens, Niels; Nasir, Mehmet Nail ULg; Crowet, Jean-Marc ULg et al

in Biochimica et Biophysica Acta - Biomembranes (2017), 1859(3), 331-339

Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It ... [more ▼]

Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It has been established that interaction with the cellular membrane is central to the mode of action of CLPs. In this work, we focus on the CLPs of the so-called viscosin group, aiming to assess the impact of the main structural variations observed within this group on both the antimicrobial activity and the interaction with model membranes. The antimicrobial activity of viscosin, viscosinamide A, WLIP and pseudodesmin A were all tested on a broad panel of mainly Gram-positive bacteria. Their capacity to permeabilize or fuse PG/PE/cardiolipin model membrane vesicles is assessed using fluorescent probes. We find that the Glu2/Gln2 structural variation within the viscosin group is the main factor that influences both the membrane permeabilization properties and the minimum inhibitory concentration of bacterial growth, while the configuration of the Leu5 residue has no apparent effect. The CLPmembrane interactions were further evaluated using CD and FT-IR spectroscopy on model membranes consisting of PG/PE/cardiolipin or POPC with or without cholesterol. In contrast to previous studies, we observe no conformational change upon membrane insertion. The CLPs interact both with the polar heads and aliphatic tails of model membrane systems, altering bilayer fluidity, while cholesterol reduces CLP insertion depth [less ▲]

Detailed reference viewed: 59 (10 ULg)
Full Text
Peer Reviewed
See detailUnderstanding the causes and consequences of past marine carbon cycling variability through models
Hülse, Dominik; Arndt, Sandra; Wilson, Jamie D. et al

in Earth-Science Reviews (2017), 171

On geological time-scales, the production and degree of recycling of biogenic carbon in the marine realm and ultimately its removal to sediments, exerts a dominant control on atmospheric CO2 and hence ... [more ▼]

On geological time-scales, the production and degree of recycling of biogenic carbon in the marine realm and ultimately its removal to sediments, exerts a dominant control on atmospheric CO2 and hence variability in climate. This is a highly complex system involving a myriad of inter-connected biological, chemical, and physical processes. For this reason alone, linking observations, often highly abstracted in the form of proxies, to the primary processes involved and ultimately to explanatory hypotheses for specific geological events and transitions, is challenging. The past few decades have seen a progressive improvement in theoretical and process-based understanding of the various components that make up the marine carbon cycle and, hand-in-hand with this, the development of numerical model representations of the complete system. Models have also been designed and/or adapted with paleoclimate questions in mind and applied to quantitatively explore the role of the marine carbon cycle in both perturbations and long-term geologic evolutionary trends in global climate, and possible feedbacks between them. However, we must ask whether paleoclimate models incorporate sufficiently appropriate representations of the dynamics and sensitivities of the marine carbon cycle, and indeed, whether in the geological context, we really know what these dynamics are. Here we provide a comprehensive overview of how marine carbon cycling and the biological carbon pump is treated in available paleoclimate models, with the aim of critically evaluating their ability to help interpret past marine carbon cycle and climate dynamics. To this end, we first provide an overview of commonly used paleoclimate models and some of their associated paleo-applications, drawing from a wide range of global carbon cycle box models and Earth system Models of Intermediate Complexity (EMICs). Secondly, we review and evaluate the three dominant processes involved in the cycling of organic and inorganic carbon in the marine system and how they are represented in models, namely: biological productivity at the ocean surface, remineralisation/dissolution of particulate carbon within the water column, and the benthic-pelagic coupling at the seafloor. We generate and employ illustrative examples using the model GENIE to show how different parameterisations of water-column and sediment processes can lead to significantly different model projections. Our compilation reveals the prevalence of static parametrisations of marine carbon cycling among existing paleoclimate models, which are commonly empirically derived from present-day observations. Although such approaches tend to represent carbon transfer in the modern ocean well, they are potentially compromised in their ability to reflect the true degree of freedom and strength of feedbacks with respect to past climate events, particularly those characterised by environmental boundary conditions that differ fundamentally from today. Finally, we discuss the importance of using models of different complexities and how questions of model uncertainty may start to be addressed. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailCrassicauda boopis in a fin whale (Balaenoptera physalus) ship-struck in the eastern North Atlantic Ocean
Lempereur, Laetitia ULg; Delobelle, Morgan; Doom, Marjan et al

in Parasitology open (2017), 3

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailLong-term care social insurance: How to avoid big losses?
Klimaviciute, Justina ULg; Pestieau, Pierre ULg

in International Tax and Public Finance (2017)

Long-term care (LTC) needs are expected to rapidly increase in the next decades, and at the same time, the main provider of LTC, namely the family, is stalling. This calls for more involvement of the ... [more ▼]

Long-term care (LTC) needs are expected to rapidly increase in the next decades, and at the same time, the main provider of LTC, namely the family, is stalling. This calls for more involvement of the state that today covers <20% of these needs and most often in an inconsistent way. Besides the need to help the dependent poor, there is a mounting concern in the middle class that a number of dependent people are incurring costs that could force them to sell all their assets. In this paper, we study the design of a social insurance program that meets this concern. Following Arrow (Am Econ Rev 53:941–973, 1963), we suggest a policy that is characterized by complete insurance above a deductible amount. [less ▲]

Detailed reference viewed: 38 (3 ULg)
Full Text
Peer Reviewed
See detailGuidelines for the Detection of Babesia and Theileria Parasites.
Lempereur, Laetitia ULg; Beck, Relja; Fonseca, Isabel et al

in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2017), 17(1), 51-65

The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They ... [more ▼]

The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They include protozoan parasites that infect erythrocytes of a variety of vertebrate hosts, including domestic and wild animals, with some Babesia spp. also infecting humans. Babesia sporozoites transmitted in the tick's saliva during the bloodmeal directly infect erythrocytes, where they asexually multiply to produce pear-shaped merozoites in the process of merogony; whereas a pre-erythrocytic schizogonic life stage in leukocytes is found in Theileria and precedes merogony in the erythrocytes. The wide spectrum of Babesia and Theileria species and their dissimilar characteristics with relation to disease severity, transmission, epidemiology, and drug susceptibility stress the importance of accurate detection of babesiosis and theileriosis and their causative agents. These guidelines review the main methods currently used for the detection of Babesia and Theileria spp. for diagnostic purposes as well as epidemiological studies involving their vertebrate hosts and arthropod vectors. Serological methods were not included once they did not indicate current infection but rather exposure. [less ▲]

Detailed reference viewed: 95 (1 ULg)
Full Text
Peer Reviewed
See detailAssessment of extreme value overestimations with equivalent static wind loads
Blaise, Nicolas ULg; Andrianne, Thomas ULg; Denoël, Vincent ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2017)

The wind-resistant design using equivalent static wind loads is convenient for structural engineers. This paper studies the reliability of such an approach in the case of non-Gaussianities in both ... [more ▼]

The wind-resistant design using equivalent static wind loads is convenient for structural engineers. This paper studies the reliability of such an approach in the case of non-Gaussianities in both aerodynamic pressures and responses. These non-Gaussianities are responsible for overestimations of envelope values and may result in uneconomical designs, if not appropriately understood, assessed and addressed. In this study, it is shown that the equivalent static wind loads defined with the Conditional Expected Load method, which extends the physical meaning of the Load-Response Correlation approach in a non-Gaussian framework, improves the issue of overestimations of envelope values. Several envelopes of structural responses are considered: the mean of extremes and the 86% quantiles of extremes, together with two reference periods (10 min and 1 h). Extensive wind tunnel measurements have been collected, which correspond to 371 h full scale. This study is undertaken for quasi-static analysis of structures and is illustrated with a low-rise building. [less ▲]

Detailed reference viewed: 28 (3 ULg)
Full Text
Peer Reviewed
See detailThe neural bases of proactive and reactive control processes in normal aging
Manard, Marine ULg; François, Sarah ULg; Phillips, Christophe ULg et al

in Behavioural Brain Research (2017), 320

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain ... [more ▼]

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain intact. As proactive and reactive control abilities are associated with specific brain networks, this study investigated age-related effects on the neural substrates associated with each kind of control. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to groups of 20 young and 20 older healthy adults. Based on the theory of dual mechanisms of control, the Stroop task has been built to induce proactive or reactive control depending on task context. Results. Behavioral results (p < .05) indicated faster processing of interfering items in the mostly incongruent (MI) than the mostly congruent (MC) context in both young and older participants. fMRI results showed that reactive control is associated with increased activity in left frontal areas for older participants. For proactive control, decreased activity in the bilateral anterior cingulate cortex was associated with more activity in the right middle frontal gyrus in the older than the younger group. Conclusion. These observations support the hypothesis that aging affects the neural networks associated with reactive and proactive cognitive control differentially. These age-related changes are very similar to those observed in young adults with low dopamine availability, suggesting that a general mechanism (prefrontal dopamine availability) may modulate brain networks associated with various kinds of cognitive control. [less ▲]

Detailed reference viewed: 44 (10 ULg)
Full Text
Peer Reviewed
See detailGlobal longitudinal strain predicts outcome after MitraClip implantation for secondary mitral regurgitation
Citro, R; Baldi, C; Lancellotti, Patrizio ULg et al

in Journal of Cardiovascular Medicine (Hagerstown, Md.) (2017)

AIM: The aim of this study was to assess preoperative determinants, prevalence, and prognostic impact of left ventricular (LV) reverse remodeling (LVRR) in patients with secondary mitral regurgitation ... [more ▼]

AIM: The aim of this study was to assess preoperative determinants, prevalence, and prognostic impact of left ventricular (LV) reverse remodeling (LVRR) in patients with secondary mitral regurgitation (SMR), undergoing MitraClip implantation (MCi). METHODS: From March 2012 to January 2015, a total of 41 consecutive patients with moderate-to-severe SMR treated successfully with MCi were enrolled. All patients underwent clinical and echocardiographic follow-up after MCi. Global longitudinal strain (GLS) was obtained using two dimensional speckle tracking analysis. A reduction in LV end-systolic volume more than 10% compared with baseline was considered as a marker of LVRR. Patients were divided into two groups according to the presence or absence of LVRR. Cardiac events were defined as the occurrence of cardiac death, rehospitalization for worsening heart failure, and mitral valve surgery. RESULTS: On univariable analysis, EuroSCORE II and GLS were associated with LVRR. On multivariable logistic regression analysis, GLS was the only independent correlate of LVRR (P = 0.004). A receiver operating characteristic curve identified a cutoff value for GLS of -9.25% (P < 0.001) associated with LVRR, with a sensitivity and specificity of 81 and 74%, respectively. New York Heart Failure Association class more than 2 after MCi, absence of LVRR after MCi, and preoperative GLS more than -9.25% were significantly correlated with adverse cardiac events at long-term follow-up. On multivariable logistic regression analysis, GLS was the only independent predictor of composite adverse cardiac events at 2-year follow-up. CONCLUSION: A worse preoperative GLS predicts no LVRR and is associated with adverse long-term outcome after successful MCi for SMR. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailPond drying cues and their effects on growth and metamorphosis in a fast developing amphibian
Székely, Diana ULg; Denoël, Mathieu ULg; Székely, Paul et al

in Journal of Zoology (2017)

The hydroperiod of breeding habitats imposes a strong selection on amphibians and pond-breeding species usually exhibit a high degree of plasticity in the duration of larval period. However, the potential ... [more ▼]

The hydroperiod of breeding habitats imposes a strong selection on amphibians and pond-breeding species usually exhibit a high degree of plasticity in the duration of larval period. However, the potential for phenotypic plasticity in fast developing species was investigated only in a small number of anurans, and the specific response to environmental cues such as low water versus decreasing water level, as well as the effects of such cues on particular developmental stages, are even less understood. In this context, we investigated the plastic response to pond desiccation in a neotropical species (Ceratophrys stolzmanni) by raising tadpoles in three water level treatments: constant high, constant low and decreasing. The growth rates were the highest reported for amphibian tadpoles (up to 0.3g/day) and the time to metamorphosis was short in all treatments, with the fastest developing tadpole metamorphosing in only 16 days after egg deposition. Individuals from the constant high water level treatment had a higher growth rate than those in the other two treatments, whereas decreasing and constant low water levels had similar effects on development, speeding up metamorphosis. In turn, this involved a cost as these tadpoles had a lower body size and mass at metamorphosis than the ones raised in constant high water levels. The final stages of metamorphosis, when tadpoles are the most vulnerable, were shorter in tadpoles exposed to a decreasing water level, allowing them to leave water quickly. Our experiment demonstrates that phenotypic plasticity is maintained even in environments devoid of permanent aquatic habitats. Ceratophryd tadpoles are able to shorten their developmental time when they perceive a risk of desiccation and react similarly to cues coming from the two unfavorable water conditions showing their adaptation to ephemeral and unpredictable breeding habitats. [less ▲]

Detailed reference viewed: 41 (8 ULg)
Full Text
Peer Reviewed
See detailThe Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission.
Zeippen, Caroline ULg; Javaux, Justine; Xiao, Xue ULg et al

in Journal of Virology (2017), 91(13),

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a ... [more ▼]

Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and in vitro, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection but is poorly released from vaginal epithelial cells and fails to pass from the female to the male genital tract during sexual contact. Thus, we show that the regulation of virion binding is a key component of spontaneous gammaherpesvirus transmission.IMPORTANCE Gammaherpesviruses are responsible for many important diseases in both animals and humans. Some important aspects of their life cycle are still poorly understood. Key among these is viral transmission. Here we show that the major envelope glycoprotein of murid herpesvirus 4 functions not in entry or dissemination but in virion release to allow sexual transmission to new hosts. [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailAssessing cultivar resistance to Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae) using a phenotyping method under semi-field conditions
Chavalle, Sandrine ULg; Jacquemin, Guillaume; De Proft, Michel

in Journal of Applied Entomology (2017)

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin), can significantly reduce wheat yield. Growing resistant wheat cultivars is an effective way of managing this pest. The assessment of ... [more ▼]

The orange wheat blossom midge, Sitodiplosis mosellana (Géhin), can significantly reduce wheat yield. Growing resistant wheat cultivars is an effective way of managing this pest. The assessment of cultivar resistance in field trials is difficult because of unequal pressure of S. mosellana caused by differences in cultivar heading dates relative to the flight period of S. mosellana adult females and huge variations of egg laying conditions from 1 day to another. To overcome these hurdles and to expose all cultivars homogeneously to the pest, an assessment method of cultivar resistance was developed under semi-field conditions. In 2015, the resistance of 64 winter wheat cultivars to S. mosellana was assessed. Few or no larvae developed in the ears of resistant cultivars, but in susceptible cultivars, large numbers of larvae developed. Seventeen cultivars proved to be resistant, whereas 47 were susceptible. The identification of new resistant cultivars offers more opportunities to manage S. mosellana. The phenotyping method is easy, cheap, efficient and reliable. It can be used to guide the breeding of new resistant wheat cultivars. Using specific midge populations, this method could also be used in research on new resistance mechanisms in winter wheat or in other cereal species. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailRecommendations on the Echocardiographic Assessment of Aortic Valve Stenosis: A Focused Update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography
Baumgartner, H; Hung, J; Bermejo, J et al

in Journal of the American Society of Echocardiography (2017)

Echocardiography is the key tool for the diagnosis and evaluation of aortic stenosis. Because clinical decision-making is based on the echocardiographic assessment of its severity, it is essential that ... [more ▼]

Echocardiography is the key tool for the diagnosis and evaluation of aortic stenosis. Because clinical decision-making is based on the echocardiographic assessment of its severity, it is essential that standards are adopted to maintain accuracy and consistency across echocardiographic laboratories. Detailed recommendations for the echocardiographic assessment of valve stenosis were published by the European Association of Echocardiography and the American Society of Echocardiography in 2009. In the meantime, numerous new studies on aortic stenosis have been published with particular new insights into the difficult subgroup of low gradient aortic stenosis making an update of recommendations necessary. The document focuses in particular on the optimization of left ventricular outflow tract assessment, low flow, low gradient aortic stenosis with preserved ejection fraction, a new classification of aortic stenosis by gradient, flow and ejection fraction, and a grading algorithm for an integrated and stepwise approach of aortic stenosis assessment in clinical practice. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailManagement of abdominal wall desmoid tumors.
DETRY, Olivier ULg

in Acta Chirurgica Belgica (2017)

Detailed reference viewed: 52 (1 ULg)
Full Text
Peer Reviewed
See detailMaking a Case for Case Reports: The ECCO-CONFER Viewpoint on Investigating Rare Events in a Medical World Reigned by Group-comparative Statistics.
Katsanos, Konstantinos H.; Domenech, Eugeni; Rahier, Jean-Francois et al

in Journal of Crohn's and Colitis [=JCC] (2017)

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailVulnerability evaluation of millet and sorghum cropping system to climate change and adoption of new technologies in Mali
Sissoko, Penda ULg; Aune, Jens B.; Senneväg, Gry et al

in Asian Journal of Science and Technology (2017), 8(1), 4176-4182

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi ... [more ▼]

This study analyzes the vulnerability of agricultural cropping systems based on millet and sorghum and the adoption of new technologies in Sahelian and Sudano - Sahelian areas in Mali (West Africa). Semi-structured interviews (ISS) using questionnaires addressed to the chiefs of family farm (FAE) were used for the collection of data. The descriptive statistics and matrices were realized for the data analysis using the following softwares: EXCEL and SPSS20.The results of the surveys conducted in 2014 among 360 farms in Sahelian and Sudano-Sahelian areas, shows that agricultural producers are aware of the main factors affecting the productivity of their cropping system and food security of agricultural holdings. Rainfall variability, characterized by failure and irregularity of rains is the main constraint of cropping systems based on millet and sorghum as stated by 97% of surveyed producers, followed by soil poverty 81%, and the lack of agricultural equipment 47%. The impacts of these factors at the farms level are translated by a decrease in the crops yields and on the frequency of the shortages in foodstuffs which are observed by 98% of the farms every year and more than 50% every 3 years. To reduce vulnerabilities, practices and innovations were adopted by farms as strategies. The main concern fertilizer micro dosing technics, seed soaking, improved varieties, organic and mineral fertilization, soils and water management technics, mechanical sowing, and agro forestry were adopted as strategies. [less ▲]

Detailed reference viewed: 25 (7 ULg)
Full Text
Peer Reviewed
See detailReliability of muscle strength measures obtained with a hand-held dynamometer in an elderly population.
Buckinx, Fanny ULg; Croisier, Jean-Louis ULg; Reginster, Jean-Yves ULg et al

in Clinical Physiology & Functional Imaging (2017), 37(3), 332-40

BACKGROUND: The objective of this study was to assess the reliability of a hand-held dynamometer for isometric strength measurements among nursing home residents. METHODS: The isometric muscle strength of ... [more ▼]

BACKGROUND: The objective of this study was to assess the reliability of a hand-held dynamometer for isometric strength measurements among nursing home residents. METHODS: The isometric muscle strength of nursing home residents was assessed for eight different muscle groups, using a hand-held dynamometer, the MicroFET2 device. Strength measurements were performed at baseline and after 4 days by the same operator and after 8 days by a second operator. Intraclass coefficients (ICC) were computed to assess the relative reliability, whereas the minimal detectable change (MDC%) was calculated to assess the absolute reliability of the test-retest of the MicroFET2 used by one single operator or by two different ones. RESULTS: Thirty nursing home residents (75.0 +/- 11.2 years, 50% of women) were enrolled in this study. ICC of the test-retest with one single operator ranged from 0.60 (0.37-0.83) for the ankle extensors to 0.85 (0.74-0.95) for the elbow flexors. When considering the test-retest with two different operators, the ICC values ranged from 0.62 (0.41-0.84) for the ankle extensors to 0.87 (0.79-0.96) for the elbow extensors. For the absolute reliability, MDC% varies from 27.64 (elbow flexors) to 81.97 (ankle extensors) when performed in intra-observer. In interobserver condition, MDC%, respectively, varies from 24.38 (elbow extensors) 67.59 (ankle extensors). CONCLUSION: Using standardized protocol and standardized instructions to patients, a high relative and moderate absolute reliability was observed for all but ankle muscle groups, making this hand-held dynamometer a potential tool for research in the elderly population. [less ▲]

Detailed reference viewed: 56 (11 ULg)
Full Text
Peer Reviewed
See detailTime related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.
Klaassens, Bernadet L.; Rombouts, Serge A. R. B.; Winkler, Anderson ULg et al

in Human Brain Mapping (2017), 38(1), 308-325

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the ... [more ▼]

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired per subject during this randomized, double blind, placebo-controlled, crossover study. Within-group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P < 0.05, FWE-corrected) using a non-parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self-referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects. Hum Brain Mapp 38:308-325, 2017. (c) 2016 Wiley Periodicals, Inc. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detail3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study
BERNARD, Anne-Catherine ULg; Addetia, K; DULGHERU, Raluca Elena ULg et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of ... [more ▼]

Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2) than in women (82 and 35 mL/m2; P < 0.0001). Conversely, lower limits of LV ejection fraction were higher in women than in men (51% vs. 50%; P < 0.01). Similarly, all strain components were higher in women than in men. Lower range was -18.6% in men and -19.5% in women for 3D longitudinal strain, -27.0% and -27.6% for 3D circumferential strain, -33.2% and -34.4% for 3D tangential strain and 38.8% and 40.7% for 3D radial strain, respectively. LV volumes decreased with age in both genders (P < 0.0001), whereas LV ejection fraction increased with age only in men. Among 3DE LV strain components, the only one, which did not change with age was longitudinal strain. Conclusion: The NORRE study provides applicable 3D echocardiographic reference ranges for LV function assessment. Our data highlight the importance of age- and gender-specific reference values for both LV volumes and strain. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailComparison between sedation and general anesthesia for high resolution computed tomographic characterization of canine idiopathic pulmonary fibrosis in west highland white terriers
Roels, Elodie ULg; Couvreur, Thierry; Farnir, Frédéric ULg et al

in Veterinary Radiology & Ultrasound (2017)

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive interstitial lung disease mainly affecting West Highland white terriers (WHWTs). Thoracic high-resolution computed tomographic (T-HRCT ... [more ▼]

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive interstitial lung disease mainly affecting West Highland white terriers (WHWTs). Thoracic high-resolution computed tomographic (T-HRCT) findings for CIPF acquired under general anesthesia have been described previously. However, the use of general anesthesia may be contraindicated for some affected dogs. Sedation may allow improved speed and safety, but it is unknown whether sedation would yield similar results in identification and grading of CIPF lesions. The aim of this prospective, observational, method-comparison, case-control study was to compare findings from T-HRCT images acquired under sedation versus general anesthesia for WHWTs affected with CIPF (n=11) and age-matched controls (n=9), using the glossary of terms of the Fleischner Society and a scoring system. Ground-glass opacity (GGO) was identified in all affected WHWTs for both sedation and general anesthesia acquisitions, although the GGO extent varied significantly between the two acquisitions (P<0.001). Ground-glass opacity was the sole lesion observed in control dogs (n=6), but was less extensive compared with affected WHWTs. Identification and grading of a mosaic attenuation pattern differed significantly between acquisitions (P<0.001). Identification of lesions such as consolidations, nodules, parenchymal and subpleural bands, bronchial wall thickening, and bronchiectasis did not differ between acquisitions. The present study demonstrated that T-HRCT obtained under sedation may provide different information than T-HRCT obtained under general anesthesia for identification and grading of some CIPF lesions, but not all of them. These differences should be taken into consideration when general anesthesia is contraindicated and sedation is necessary for evaluating WHWTs with CIPF. [less ▲]

Detailed reference viewed: 43 (18 ULg)
Full Text
Peer Reviewed
See detailThe inventory-routing problem of returnable transport items with time windows and simultaneous pickup and delivery in closed-loop supply chains
Iassinovskaia, Galina; Limbourg, Sabine ULg; RIANE, Fouad

in International Journal of Production Economics (2017), (183), 570-582

Reducing environmental impact, related regulations and potential for operational benefits are the main reasons why companies share their returnable transport items (RTIs) among the different partners of a ... [more ▼]

Reducing environmental impact, related regulations and potential for operational benefits are the main reasons why companies share their returnable transport items (RTIs) among the different partners of a closed-loop supply chain. In this paper, we consider a producer, located at a depot, who has to distribute his products packed in RTIs to a set of customers. Customers define a time window wherein the service can begin. The producer is also in charge of the collection of empty RTIs for reuse in the next production cycle. Each partner has a storage area composed of both empty and loaded RTI stock, as characterized by initial levels and maximum storage capacity. As deliveries and returns are performed by a homogeneous fleet of vehicles that can carry simultaneously empty and loaded RTIs, this research addresses a pickup and delivery inventory-routing problem within time windows (PDIRPTW) over a planning horizon. A mixed-integer linear program is developed and tested on small-scale instances. To handle more realistic large-scale problems, a cluster first-route second matheuristic is proposed. [less ▲]

Detailed reference viewed: 73 (9 ULg)
Full Text
Peer Reviewed
See detailRange size heritability and diversification patterns in the liverwort genus Radula
Patiño, J.; Wang, J.; Renner, M.A.M. et al

in Molecular Phylogenetics & Evolution (2017), 106

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailEditorial: Sustainability of rural systems: balancing heritage and innovation
Schmitz, Serge ULg; Dubois, Charline ULg

in Belgeo (2017), 2016(4),

This editorial relates the 24th colloquium of the Commission on the Sustainability of Rural Systems held in Liege and presents the main goals of the Commission. It introduces and discusses briefly the ten ... [more ▼]

This editorial relates the 24th colloquium of the Commission on the Sustainability of Rural Systems held in Liege and presents the main goals of the Commission. It introduces and discusses briefly the ten papers selected for this special issue of Belgeo. [less ▲]

Full Text
Peer Reviewed
See detailPitfalls in supermatrix phylogenomics
Philippe, Hervé; Vienne, Damien M. De; Ranwez, Vincent et al

in European Journal of Taxonomy (2017), 283

In the mid-2000s, molecular phylogenetics turned into phylogenomics, a development that improved the resolution of phylogenetic trees through a dramatic reduction in stochastic error. While some then ... [more ▼]

In the mid-2000s, molecular phylogenetics turned into phylogenomics, a development that improved the resolution of phylogenetic trees through a dramatic reduction in stochastic error. While some then predicted “the end of incongruence”, it soon appeared that analysing large amounts of sequence data without an adequate model of sequence evolution amplifies systematic error and leads to phylogenetic artefacts. With the increasing flood of (sometimes low-quality) genomic data resulting from the rise of high-throughput sequencing, a new type of error has emerged. Termed here “data errors”, it lumps together several kinds of issues affecting the construction of phylogenomic supermatrices (e.g., sequencing and annotation errors, contaminant sequences). While easy to deal with at a single-gene scale, such errors become very difficult to avoid at the genomic scale, both because hand curating thousands of sequences is prohibitively time-consuming and because the suitable automated bioinformatics tools are still in their infancy. In this paper, we first review the pitfalls affecting the construction of supermatrices and the strategies to limit their adverse effects on phylogenomic inference. Then, after discussing the relative non-issue of missing data in supermatrices, we briefly present the approaches commonly used to reduce systematic error. [less ▲]

Detailed reference viewed: 277 (10 ULg)
Full Text
Peer Reviewed
See detailHow clinical practitioners assess frailty in their daily practice: an international survey
Bruyère, Olivier ULg; Buckinx, Fanny ULg; Beaudart, Charlotte ULg et al

in Aging Clinical and Experimental Research (2017), (On line),

NTRODUCTION: Various operational definitions have been proposed to assess the frailty condition among older individuals. Our objective was to assess how practitioners measure the geriatric syndrome of ... [more ▼]

NTRODUCTION: Various operational definitions have been proposed to assess the frailty condition among older individuals. Our objective was to assess how practitioners measure the geriatric syndrome of frailty in their daily routine. METHODS: An online survey was sent to national geriatric societies affiliated to the European Union Geriatric Medicine Society (EUGMS) and to members of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). RESULTS: A total of 388 clinicians from 44 countries answered to the survey. Most of them were medical doctors (93%), and their primary field of practice was geriatrics (83%). Two hundred and five clinicians (52.8%) always assessed frailty in their daily practice, 38.1% reported to "sometimes" measure it, and 9.1% never assess it. A substantial proportion of clinicians (64.9%) diagnose frailty using more than one instrument. The most widely used tool was the gait speed test, adopted by 43.8% of the clinicians, followed by clinical frailty scale (34.3%), the SPPB test (30.2%), the frailty phenotype (26.8%) and the frailty index (16.8%). CONCLUSION: A variety of tools is used to assess frailty of older patients in clinical practice highlighting the need for standardisation and guidelines. [less ▲]

Full Text
Peer Reviewed
See detailPhotoreversibility and biocompatibility of polydimethylsiloxane-coumarin as adjustable intraocular lens material
Jellali, Rachid; Bertrand, Virginie ULg; Alexandre, Michaël et al

in Macromolecular Bioscience (2017)

Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomed- ical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a ... [more ▼]

Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomed- ical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a photoreversible PDMS-coumarin network, whose shape and properties can be adjusted postoperatively in a noninvasive manner, is developed. The synthesis of PDMS-cou- marin is achieved by amidation of a coumarin acid chloride derivative with amine-function- alized PDMSs. Under exposure of λ > 300 nm, these polymers can be cured by dimerization of coumarin. The cured polymers can be uncrosslinked via photocleavage of cyclobutane dimers upon illumination at λ < 290 nm. The diffusion of linear PDMSs in a crosslinked network and the controlled shape modification are studied, which demonstrate that these polymers are good candidates for adjustable IOL application. IOL disks prepared from these materials show high hydrophobicity and good transparency. In vitro cytotoxicity, lens epithelial cell adhesion assays, and rabbit host reaction against implanted disks demonstrate the biocompatibility of the polymer. [less ▲]

Detailed reference viewed: 29 (6 ULg)
Full Text
Peer Reviewed
See detailThe effect of feedback on children’s metacognitive judgments: a heuristic account
Geurten, Marie ULg; Meulemans, Thierry ULg

in Journal of Cognitive Psychology (2017), 29(2), 184-201

In three experiments, we investigated whether the feedback effect on the accuracy of children’s metacognitive judgments results from an improvement in monitoring processes or the use of the Anchoring-and ... [more ▼]

In three experiments, we investigated whether the feedback effect on the accuracy of children’s metacognitive judgments results from an improvement in monitoring processes or the use of the Anchoring-and-Adjustment heuristic. Experiment 1 revealed that adding feedback increased the accuracy of young children’s (aged 4, 6, and 8 years) memory prediction. In Experiment 2, the influence of an external anchor on children’s metacognitive judgment was established. Finally, in Experiment 3, two memory tasks that differed in terms of difficulty were administered. Participants were randomly assigned to an anchoring (high/low/no anchor) and a feedback (feedback/no feedback) condition. Results demonstrated that children in the feedback condition adjusted their predictions toward the feedback, regardless of the task’s difficulty. These findings are consistent with the hypothesis that external information provided by feedback is used as an anchor for judgment. This interpretation is strengthened by the correlation found between the two scores computed to assess participants’ susceptibility to anchoring and feedback effects, which indicates that children who are more sensitive to the anchoring effect are also more sensitive to the feedback effect. [less ▲]

Detailed reference viewed: 17 (3 ULg)
Full Text
Peer Reviewed
See detailA novel SMAD3 mutation caused multiple aneurysms in a patient without osteoarthritis symptoms
Courtois, Audrey ULg; Coppieters, Wouter ULg; BOURS, Vincent ULg et al

in European Journal of Medical Genetics (2017)

Detailed reference viewed: 41 (4 ULg)
Full Text
Peer Reviewed
See detailReconstructing Cenozoic vegetation from proxy data and models – A NECLIME synthesis (Editorial)
François, Louis ULg; Bruch, A. A.; Utescher, T. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

[No abstract available]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailPartial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin.
Farcas, E.; Bouckaert, C.; Servais, Anne-Catherine ULg et al

in Analytica Chimica Acta (2017), 984

With the emergence of more challenging targets, a relatively new approach, fragment-based drug discovery (FBDD), proved its efficacy and gained increasing importance in the pharmaceutical industry. FBDD ... [more ▼]

With the emergence of more challenging targets, a relatively new approach, fragment-based drug discovery (FBDD), proved its efficacy and gained increasing importance in the pharmaceutical industry. FBDD identifies low molecular-weight (MW) ligands (fragments) that bind to biologically important macromolecules, then a structure-guided fragment growing or merging approach is performed, contributing to the quality of the lead. However, to select the appropriate fragment to be evolved, sensitive analytical screening methods must be used to measure the affinity in the muM or even mM range. In this particular context, we developed a robust and selective partial filling affinity CE (ACE) method for the direct binding screening of a small fragment library in order to identify new thrombin inhibitors. To demonstrate the accuracy of our assay, the complex dissociation constants of three known thrombin inhibitors, namely benzamidine, p-aminobenzamidine and nafamostat were determined and found to be in good concordance with the previously reported values. Finally, the screening of a small library was performed and demonstrated the high discriminatory power of our method towards weak binders compared to classical spectrophotometric activity assay, proving the interest of our method in the context of FBDD. [less ▲]

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

Detailed reference viewed: 54 (23 ULg)
Full Text
Peer Reviewed
See detailAdaptation response surfaces for managing wheat under perturbed climate and CO2 in a Mediterranean environment
Ruiz-Ramos, M.; Ferrise, R.; Rodríguez, A. et al

in Agricultural Systems (2017)

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailInhibition of ethylene synthesis reduces salt-tolerance in tomato wild relative species Solanum chilense
Gharbi, E.; Martínez, J.-P.; Benahmed, H. et al

in Journal of Plant Physiology (2017), 210

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of ... [more ▼]

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of Solanum chilense (accession LA4107) and of cultivated glycophyte Solanum lycopersicum (cv. Ailsa Craig) were cultivated for 7 days in nutrient solution containing 0 or 125 mM NaCl in the presence or absence of the inhibitor of ethylene synthesis (aminovinylglycine (AVG) 2 μM). Salt-induced ethylene synthesis in S. chilense occurred concomitantly with an increase in stomatal conductance, an efficient osmotic adjustment and the maintenance of carbon isotope discrimination value (Δ13C). In contrast, in S. lycopersicum, salt stress decreased stomatal conductance and Δ13C values while osmotic potential remained higher than in S. chilense. Inhibition of stress-induced ethylene synthesis by AVG decreased stomatal conductance and Δ13C in S. chilense and compromised osmotic adjustment. Solanum chilense behaved as an includer and accumulated high amounts of Na in the shoot but remained able to maintain K nutrition in the presence of NaCl. This species however did not stimulate the expression of genes coding for high-affinity K transport but genes coding for ethylene responsive factor ERF5 and JREF1 were constitutively more expressed in S. chilense than in S. lycopersicum. It is concluded that ethylene plays a key role in salt tolerance of S. chilense. © 2016 [less ▲]

Detailed reference viewed: 25 (1 ULg)
Full Text
Peer Reviewed
See detailAn investigation on the use of coarse volcanic scoria as sand in Portland cement mortar
Juimo Tchamdjou, Willy Hermann; Grigoletto, Sophie ULg; Michel, Frédéric ULg et al

in Case studies in Building Materials (2017), 7

In this study, the utilization of coarse volcanic scoria CVS as sand in Portland cement mortar was investigated. The aim of this study is to give some physical properties, mechanical properties and ... [more ▼]

In this study, the utilization of coarse volcanic scoria CVS as sand in Portland cement mortar was investigated. The aim of this study is to give some physical properties, mechanical properties and durability properties of CVS mortars investigated at short term of curing in comparison with a reference mortar. Investigation was carried out on three groups of mortar samples according to the proportion of fine particles on the coarse volcanic scoria, “low” for the first group MCVS1, “average” for the second group MCVS2 and “high” for the third group MCVS3. The reference mortar has been made with standard sand. The water–cement w/c ratio and sand/cement s/c ratio used in the mixtures were 0.5 and 3, respectively according to European Standard EN 196-1- 2005. The particle size of CVS aggregates used to prepare mortar mixtures were between 0.08 mm and 2.00 mm like in the standard sand. Compressive and flexural strengths were tested at mortar age of 28 days. The results revealed improved compressive and flexural strengths, which were maximal for the MCVS3 samples. Unit weight increased with the ratio of fine CVS size between 0.08–1.00 mm. Sorptivity and carbonation depth decrease as the ratio of fine CVS increase. Based on these results, using Cameroonian volcanic scoria in the appropriate particles size ratio composition will improve these mortar characteristics. CVS mortars can be used for more applications for building construction in Cameroon and all over the world, especially in regions where volcanic scoria resources are abundant. [less ▲]

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailConcise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.
Franco, Benedicte; Malgrange, Brigitte ULg

in Stem cells (Dayton, Ohio) (2017)

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice ... [more ▼]

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice harbor some progenitor cells that retain the ability to give rise to new hair cells. These progenitor cells are in fact supporting cells. Upon hair cells loss, those cells are able to generate new hair cells both by direct transdifferentiation or following cell cycle re-entry and differentiation. However, this property of supporting cells is progressively lost after birth. Here, we review the molecular mechanisms that are involved in mammalian hair cell development and regeneration. Manipulating pathways used during development constitute good candidates for inducing hair cell regeneration after injury. Despite these promising studies, there is still no evidence for a recovery following hair cells loss in adult mammals. Stem Cells 2017. [less ▲]

Detailed reference viewed: 25 (2 ULg)
Full Text
Peer Reviewed
See detailRational and design of EuroCRT: an international observational study on multi-modality imaging and cardiac resynchronization therapy
Donal, E; Delgado, V; Magne, J et al

in European Heart Journal - Cardiovascular Imaging (2017)

Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several ... [more ▼]

Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT. METHODS: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging. [less ▲]

Detailed reference viewed: 45 (1 ULg)
Full Text
Peer Reviewed
See detailPratiques phytosanitaires des producteurs de tomates du Burkina Faso et risques pour la santé et l’environnement
Son, Diakalia ULg; Somda, Irénée; Legrève, Anne et al

in Cahiers Agricultures (2017), 26(2), 6

To assess the phytosanitary practices of tomato growers in Burkina Faso, surveys were carried out in 2015 and 2016 among 316 producers in the West and North zones of the country. Ninety percent of ... [more ▼]

To assess the phytosanitary practices of tomato growers in Burkina Faso, surveys were carried out in 2015 and 2016 among 316 producers in the West and North zones of the country. Ninety percent of pesticides used by producers are purchased in local markets without guarantee of conformity or quality. Lambda-cyhalothrin of the pyrethroids family was the most used active substance. The use for tomato crop of cotton pesticides increased strongly between 2015 and 2016 (þ71%). The doses used by producers are higher than the recommended ones. More than 70% of the market gardeners do not observe any measure of adequate protection from the preparation of the mixture until the end of the treatments. The respect of preharvest interval depends mostly of the crop health status and does not follow the recommendations. Empty containers of pesticides are left in fields by 53% of the farmers. These results show that the phytosanitary practices of tomato producers are unsuitable and potentially harmful to the health of farmers and consumers and to the environment. [less ▲]

Detailed reference viewed: 45 (3 ULg)
Full Text
Peer Reviewed
See detailAge-Related Differences in Strategic Monitoring During Arithmetic Problem Solving
Geurten, Marie ULg; Lemaire, Patrick

in Acta Psychologica (2017), 180

We examined the role of metacognitive monitoring in strategic behavior during arithmetic problem solving, a process that is expected to shed light on age-related differences in strategy selection. Young ... [more ▼]

We examined the role of metacognitive monitoring in strategic behavior during arithmetic problem solving, a process that is expected to shed light on age-related differences in strategy selection. Young and older adults accomplished better strategy-judgment, better strategy-selection, and strategy-execution tasks. Data showed that participants made better strategy judgments when problems were problems with homogeneous unit digits (i.e., problems with both unit digits smaller or larger than 5; 31 x 62) relative to problems with heterogeneous unit digits (i.e., problems with one unit digit smaller or larger than 5; 31 x 67) and when the better strategy was cued on rounding-up problems (e.g., 68 x 23) compared to rounding-down problems (e.g., 36 x 53). Results also indicated higher rates of better strategy judgment in young than in older adults. These aging effects differed across problem types. Older adults made more accurate judgments on rounding-up problems than on rounding-down problems when the cued strategy was rounding-up, while young adults did not show such problem-related differences. Moreover, strategy selection correlated with strategy judgment, and even more so in older adults than in young adults. To discuss the implications of these findings, we propose a theoretical framework of how strategy judgments occur in young and older adults and discuss how this framework enables to understand relationships between metacognitive monitoring and strategic behaviors when participants solve arithmetic problems. [less ▲]

Full Text
Peer Reviewed
See detailWidespread activity of multiple lineages of Usutu virus, western Europe, 2016.
Cadar, Daniel; Luhken, Renke; van der Jeugd, Henk et al

in Euro Surveillance : Bulletin Européen sur les Maladies Transmissibles = European Communicable Disease Bulletin (2017), 22(4),

In the summer of 2016, Belgium, France, Germany and the Netherlands reported widespread Usutu virus (USUV) activity based on live and dead bird surveillance. The causative USUV strains represented four ... [more ▼]

In the summer of 2016, Belgium, France, Germany and the Netherlands reported widespread Usutu virus (USUV) activity based on live and dead bird surveillance. The causative USUV strains represented four lineages, of which two putative novel lineages were most likely recently introduced into Germany and spread to other western European countries. The spatial extent of the outbreak area corresponded with R0 values > 1. The occurrence of the outbreak, the largest USUV epizootic registered so far in Europe, allowed us to gain insight in how a recently introduced arbovirus with potential public health implications can spread and become a resident pathogen in a naive environment. Understanding the ecological and epidemiological factors that drive the emergence or re-emergence of USUV is critical to develop and implement timely surveillance strategies for adequate preventive and control measures. Public health authorities, blood transfusion services and clinicians in countries where USUV was detected should be aware of the risk of possible USUV infection in humans, including in patients with unexplained encephalitis or other neurological impairments, especially during late summer when mosquito densities peak. [less ▲]

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailLooking for a Dialogue between Farmers and Scientific Soil Knowledge: Learnings from an Ethno-Geomorphopedological Study in a Philippine’s Upland Village
Richelle, Lola; Visser, Marjolein; Bock, Laurent ULg et al

in Agroecology and Sustainable Food Systems (2017), 0(ja),

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailA dynamic, sex-specific expression pattern of genes regulating thyroid hormone action in the developing zebra finch song control system
Raymaekers, S.R.; Verbeure, W.; Ter Haar, S.M. et al

in General and Comparative Endocrinology (2017), 240

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel ... [more ▼]

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel- lent model to study developmental neuroplasticity. Despite the demonstrated influence of hormones such as sex steroids on this phenomenon, thyroid hormones (THs) – an important factor in neural devel- opment and maturation – have not been studied in this regard. We used in situ hybridization to compare the expression of TH transporters, deiodinases and receptors between both sexes during all phases of song development in male zebra finch. Comparisons were made in four song control nuclei: Area X, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), HVC (used as proper name) and the robust nucleus of the arcopallium (RA). Most genes regulating TH action are expressed in these four nuclei at early stages of development. However, while general expression levels decrease with age, the activating enzyme deiodinase type 2 remains highly expressed in Area X, HVC and RA in males, but not in females, until 90days post-hatch (dph), which marks the end of sensorimotor learning. Furthermore, the L-type amino acid transporter 1 and TH receptor beta show elevated expression in male HVC and RA respectively compared to surrounding tissue until adulthood. Differences compared to sur- rounding tissue and between sexes for the other TH regulators were minor. These developmental changes are accompanied by a strong local increase in vascularization in the male RA between 20 and 30 dph but not in Area X or HVC. Our results suggest that local regulation of TH signaling is an important factor in the development of the song control nuclei during the song learning phase and that TH activation by DIO2 is a key player in this process. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailWhat should a website dedicated to the postnatal period contain? A Delphi survey among parents and professionals
Slomian, Justine ULg; EMONTS, Patrick ULg; Erpicum, Martin ULg et al

in Midwifery (2017), 53

Abstract OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated ... [more ▼]

Abstract OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated that they often or always found that the information that they found on the Internet was incomplete or wrong. Many women therefore believe that health professionals should suggest reliable Internet websites for new mothers. The aim of this study was therefore to find a consensus on the content of a reliable and centralized website dedicated to mothers from the end of pregnancy to 1 year after childbirth. DESIGN: Two rounds of an online Delphi survey were used in this study. SETTING AND PARTICIPANTS: The panel of participants involved in the survey included parents (both mothers and fathers) and professionals (health professionals and professionals of early childhood for mothers of children aged 0 to 2 years). FINDINGS: Ninety-six parents and professionals participated in the first round (37.7 ± 9.76 years; 84.4% of women) and 78 in the second round. The majority of participants (94.6%) thought that a centralized website could help mothers from pregnancy to one year after childbirth. The content that the experts would like to find on a website were themed into five categories: "infants' information", "parents' information", "administrative information", "professionals' information" and "type of resources". In each category, experts highlighted the key words that they found important and should be reported on the website. The most important items highlighted by participants were baby's feeding/breastfeeding (92.8%), babies' needs (84.1%), baby blues (77.9%), postpartum depression (72.1%), management of the couple's relationship (72.1%), women's right to postnatal care (83.6%), links to reliable documents (63.9%) and a list of useful contacts (52.5%). CONCLUSIONS: This study helped to understand the questions that mothers ask themselves during the postpartum period and provided priorities to respond to their questions in the process of developing a website. [less ▲]

Full Text
Peer Reviewed
See detailIdentifying maternal needs following childbirth: A qualitative study among mothers, fathers and professionals
Slomian, Justine ULg; EMONTS, Patrick ULg; Vigneron, L. et al

in BMC Pregnancy and Childbirth (2017), 17(1), 213

Background: Pregnancy and childbirth are two critical stages in a woman’s life. Various studies have suggested that psychological distress is common during the year after childbirth. The objectives of ... [more ▼]

Background: Pregnancy and childbirth are two critical stages in a woman’s life. Various studies have suggested that psychological distress is common during the year after childbirth. The objectives of this exploratory study were (1) to explore the needs of mothers in the year following childbirth; (2) to compare these needs between mothers who did not have the feeling of living a psychological disorder or a depression and mothers who lived a psychological disorder or had the impression of living a depression; and (3) to compare the needs expressed by mothers with the perception of professionals and fathers about the mothers’ needs. Methods: First, we proceeded to 22 individual qualitative interviews followed by one focus group, with mothers, with and without experience of psychological distress. Then, we conducted 2 focus groups: one with professionals and one with fathers. Results: Needs of mothers after childbirth have been indexed in four categories: need of information, need of psychological support, need to share experience, and need of practical and material support. Women do not feel sufficiently informed about this difficult period of life. They do not feel sufficiently supported, not only from a psychological point of view but also from a more practical point of view, for example with household chores. They need to share their experience of life, they need to be reassured and they need to feel understood. It seems that some differences exist between mothers’ and professionals’ experiences but also between mothers’ and fathers’ experiences. Conclusion: Young mothers apparently feel a lack of support at different levels in the year following childbirth. This study provides ways to meet women’s needs and to try to prevent the risk of postpartum psychological distress during this period of time. [less ▲]

Full Text
Peer Reviewed
See detailLa circulation du livre médical dans les anciens Pays-Bas au second tiers du XVIe siècle
Adam, Renaud ULg

in Histoire des Sciences Médicales (2017), 51(1), 47-59

In the years 1565-1566, the Low Countries were shaken by a vast politico-religious revolt directed against Philip II. In response to the uprising and misbehaviour of parts of the population, the king ... [more ▼]

In the years 1565-1566, the Low Countries were shaken by a vast politico-religious revolt directed against Philip II. In response to the uprising and misbehaviour of parts of the population, the king established the so-called Council of Troubles, a special court active from 1567 to 1576. This institution was led in its early years by Fernando Àlvarez de Toledo, Duke of Alba and Governor General of the Low Countries. The Council of Troubles had a very close look at the production, the distribution as well as at the possession of books. At the request of the Duke of Alba, inquisitors were sent during the spring and summer of 1569 in various provinces of the Low Countries still under Spanish rule to examine bookshops and find out heretical books. These archives offer a sort of radioscopy of the book market of the Low-Countries on the eve of the Counter-Reformation. We will focus here on the situation of the city of Mons, in the county of Hainaut. The book lists written by the Duke of Alba’s emissaries describe more than 1600 books. The descriptions of the books found there are extremely high: names of authors, title, place and date of printing. The care and rigour shown by the notary in the performance of his task make this source a valuable document to study the book market in Hainaut in the second third of the 16th century and, more specifically, to study the medical book market. We will be able to discover which authors and which genres are preferred, the importance of the scientific literature compared with the popular literature, and the origin of these books. [less ▲]

Detailed reference viewed: 29 (1 ULg)
Full Text
Peer Reviewed
See detailPotential contribution of progesterone receptors to the development of sexual behavior in male and female mice.
Desroziers, Elodie; Brock, Olivier; Bakker, Julie ULg

in Hormones and Behavior (2017)

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in ... [more ▼]

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in adulthood, whereas prepubertal estradiol feminized this ability. Furthermore, we found that estradiol upregulates progesterone receptors (PR) during development, inducing both a male-and female-typical pattern of PR expression in the mouse hypothalamus. In the present study, we took advantage of a newly developed PR antagonist (ZK 137316) to determine whether PR contributes to either male- or female-typical sexual differentiation. Thus groups of male and female C57Bl/6j mice were treated with ZK 137316 or oil as control: males were treated neonatally (P0-P10), during the critical period for male sexual differentiation, and females were treated prepubertally (P15-P25), during the critical period for female sexual differentiation. In adulthood, mice were tested for sexual behavior. In males, some minor effects of neonatal ZK treatment on sexual behavior were observed: latencies to the first mount, intromission and ejaculation were decreased in neonatally ZK treated males; however, this effect disappeared by the second mating test. By contrast, female mice treated with ZK during the prepubertal period showed significantly less lordosis than OIL-treated females. Mate preferences were not affected in either males or females treated with ZK during development. Taken together, these results suggest a role for PR and thus perhaps progesterone in the development of lordosis behavior in female mice. By contrast, no obvious role for PR can be discerned in the development of male sexual behavior. [less ▲]

Detailed reference viewed: 41 (5 ULg)
Full Text
Peer Reviewed
See detailCharting ongoing change: the emergent complex subordinators the moment (that) and for fear (that)
Davidse, Kristin; Brems, Lieselotte ULg; Smith, Adam

in e-Varieng: Exploring Recent Diachrony: Corpus Studies of Lexicogrammar and Language Practices in Late Modern English (2017)

Detailed reference viewed: 20 (6 ULg)
Full Text
Peer Reviewed
See detailAntiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents
Jansen, Olivia ULg; Tchinda, Alembert T.; Loua, Jean et al

in Journal of Ethnopharmacology (2017), 203(March), 20--26

Detailed reference viewed: 38 (8 ULg)
Full Text
Peer Reviewed
See detailNew crystallographic data and formula revision of phuralumite, Al2[(UO2)3(PO4)2O(OH)](OH)3(H2O)9
Dal Bo, Fabrice ULg; Hatert, Frédéric ULg; Philippo, S

in Journal of Geosciences (2017), 62

Detailed reference viewed: 6 (4 ULg)
Full Text
Peer Reviewed
See detailEffects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study
Gaul, Charly; MAGIS, Delphine ULg; Liebler, Eric et al

in Journal of Headache and Pain (2017), 18

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve ... [more ▼]

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study. Findings: After a 2-week baseline phase, 97 patients with chronic cluster headache entered a 4-week randomised phase to receive nVNS + SoC (n = 48) or SoC alone (n = 49). All 92 patients who continued into a 4-week extension phase received nVNS + SoC. Compared with SoC alone, nVNS + SoC led to a significantly lower mean weekly attack frequency by week 2 of the randomised phase; the attack frequency remained significantly lower in the nVNS + SoC group through week 3 of the extension phase (P < 0.02). Attack frequencies in the nVNS + SoC group were significantly lower at all study time points than they were at baseline (P < 0.05). Response rates were significantly greater with nVNS + SoC than with SoC alone when response was defined as attack frequency reductions of ≥25%, ≥50%, and ≥75% from baseline (≥25% and ≥50%, P < 0.001; ≥75%, P = 0.009). The 100% response rate was 8% with nVNS + SoC and 0% with SoC alone. Conclusions: Prophylactic nVNS led to rapid, significant, and sustained reductions in chronic cluster headache attack frequency within 2 weeks after its addition to SoC and was associated with significantly higher ≥25%, ≥50%, and ≥75% response rates than SoC alone. The rapid decrease in weekly attack frequency justifies a 4-week trial period to identify responders to nVNS, with a high degree of confidence, among patients with chronic cluster headache. [less ▲]

Detailed reference viewed: 24 (1 ULg)