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See detailCulture and hallucinations: overview and future directions
Laroi, Frank ULg; Luhrmann, T; Bell, V et al

in Schizophrenia Bulletin (2014), 40

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See detailAnalyse des caractéristiques biopsychosociales observées chez 1 832 patients consultant pour des douleurs chroniques dans le service d'algologie du CHU de Liège
Faymonville, Marie-Elisabeth ULg; Blavier, Adelaïde ULg; PALMARICCIOTTI, Valérie ULg et al

in Douleur et Analgésie (2014)

This article aims to establish a "profile" of patients presenting with chronic pain in the algology service of CHU of Liège to identify possible relationships between diagnoses, psychological states and ... [more ▼]

This article aims to establish a "profile" of patients presenting with chronic pain in the algology service of CHU of Liège to identify possible relationships between diagnoses, psychological states and modes of pain management. Between 2005 and 2010 we monitored 1832 individual chronic pain patients who attended our pain clinic at the University Hospital of Liège. This paper presents the characteristics of these patients and their test scores before the treatment to assess their health status in a biopsychosocial perspective. Demographic and lifestyle as well as occupational factors, pain disability index, pain belief assessment, hospital anxiety and depression scale, SF-36 (Short Form Health Survey) and pain visual analogue scale are presented. The results have clinical implication; they suggest an adaptation of our therapeutic interventions based on these observations. © 2014 Springer-Verlag France. [less ▲]

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See detailThe diet of the Harlequin crab Lissocarcinus orbicularis, an obligate symbiont of sea cucumbers (holothuroids) belonging to the genera Thelenota, Bohadschia and Holothuria
Caulier, Guillaume; Lepoint, Gilles ULg; Van Nedervelde, Fleur et al

in Symbiosis (2014)

The present paper characterizes, for the first time, the diet of the Harlequin crab, Lissocarcinus orbicularis an obligate symbiotic crab that associates with sea cucumbers (holothuroids) belonging to the ... [more ▼]

The present paper characterizes, for the first time, the diet of the Harlequin crab, Lissocarcinus orbicularis an obligate symbiotic crab that associates with sea cucumbers (holothuroids) belonging to the genera Thelenota, Bohadschia and Holothuria. These tropical holothuroids host a rich symbiotic community in the Indo-West Pacific Ocean of which the Harlequin crab is the best known. The diet of L. orbicularis was characterized by analyzing the microscopic, molecular and isotopic signatures obtained from its gastric content. The presence of sea cucumber ossicles in the gastric mills of the crabs suggests that symbionts eat the superficial integument of their host and this was suppoarted by the fact that Holothuroid DNA was detected in the stomach of L.orbicularis after DGGE and sequencing of the 18S rDNA gene. The stable isotopic δ13C and δ15N values of crab tissues were compared with diverse potential food sources including the three holothuroids, three algae, one sea grass as well as the organic matter contained in the water column, in the sediment, and the second most abundant symbiont, the polychaete Gastrolepidia clavigera. The low δ15N values of crabs suggest that the crabs do not exclusively feed on sea cucumber tissue but assimilate diverse food sources such as sea grasses and organic matter contained in sediment that have similar δ13C values. There were no difference between the feeding of males and females but there was a positive correlation between the carapace length and the stable isotopic values indicating a shift of the food source as crabs grow larger. [less ▲]

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See detailEffect of N-acetylcysteine combined with infliximab on toxic epidermal necrolysis. A proof-of-concept study.
PAQUET, Philippe ULg; JENNES, Serge; ROUSSEAU, Anne-Françoise ULg et al

in Burns : Journal of the International Society for Burn Injuries (2014)

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See detailMesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et al

in Nephrology Dialysis Transplantation (2014), 29

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]

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See detailAltered alpha-defensin 5 expression in cervical squamocolumnar junction: implication in the formation of a viral/tumour-permissive microenvironment.
Hubert, Pascale ULg; Herman, Ludivine; Roncarati, Patrick et al

in The Journal of pathology (2014)

Human papillomavirus (HPV) infection, particularly type 16, is causally associated with cancer of the uterine cervix, which mainly develops at the squamocolumnar (SC) junction. The progression of cervical ... [more ▼]

Human papillomavirus (HPV) infection, particularly type 16, is causally associated with cancer of the uterine cervix, which mainly develops at the squamocolumnar (SC) junction. The progression of cervical HPV infections into (pre)neoplastic lesions suggests that viral antigens are not adequately recognized by innate immunity or presented to the adaptive immune system. Members of the defensin family have recently been found to inhibit viral and bacterial pathogens, to stimulate the migration of immune cells and to play a role in anticancer responses. In the present study, we focused on the poorly characterized human alpha-defensin 5 (HD-5) and its possible role in these processes. We showed that HD-5 was able to prevent HPV virion entry into cervical keratinocytes and to influence adaptive immunity. Indeed, this peptide specifically induced the chemoattraction and proliferation of both activated T lymphocytes and immature dendritic cells in a CCR2/CCR6-dependent manner and stimulated the infiltration of these professional antigen-presenting cells in a (pre)neoplastic epithelium transplanted in vivo in immunodeficient mice. No chemotactic effect was observed with plasmacytoid dendritic cells, macrophages or natural killer cells. Proliferative and angiogenic effects of HD-5 were also assessed in vitro and in vivo. However there was a striking regional disparity in expression of HD-5, being prominent in ectocervical, vaginal and vulvar neoplasia, while absent, or nearly so, in the cervical SC junction. Taken together, these results suggest one possible explanation for why the SC junction is uniquely vulnerable to both high-risk HPV infection (via reduced HD-5 expression and viral entry) and progression of neoplasia (via altered cell-mediated immune responses and altered microenvironment). Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [less ▲]

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See detailLes problèmes liés aux médicaments dans les officines belges
Huysmans; De Wulf, I; Foulon, V et al

in Journal de Pharmacie de Belgique (2014), 1

Abstract INTRODUCTION: The identification, the management and if possible the prevention of drug related problems (DRP), are the main responsibilities of pharmacists. AIM: The aims of the study were 1/to ... [more ▼]

Abstract INTRODUCTION: The identification, the management and if possible the prevention of drug related problems (DRP), are the main responsibilities of pharmacists. AIM: The aims of the study were 1/to investigate the frequency and nature of drug related problems detected by community pharmacists, 2/to inventories the frequency and nature of the interventions by community pharmacists on prescribed medicines, and 3/to evaluate whether there is a difference between DRP detection at the moment of dispensing versus in a quiet setting (a posteriori detection). METHOD: All trainees of the participating universities of Belgian were asked to contribute to a observational study. Participating pharmacists quantified DRP's and their interventions on prescribed medicines for 5 days. Registrations were made by using a web tool based on an adapted version of the classification list of PCNE. The registration took place in two phases, at the time of delivery as well as in an a posteriori verification of the prescriptions with the pharmaceutical record file of the patients. RESULTS: The study was conducted from November 2012 to April 2013 in 534 community-pharmacies with internship. During this period 9.869 prescriptions (15%) with at least one DRP were detected on a total of 64.962 prescriptions treated by tutor pharmacists. Since there could be more than one problem on a prescription, 15.952 DRP's were registered. 2.597 of the DRP's were detected by a posteriori verification. 75% of all problems had a technical cause and 37% were clinical in nature. Under the technical causes an incomplete prescription was the most common. The most frequently registered clinical causes were a drug interaction, an inopportune time of intake, a too high or too low dose and an unsuitable drug. Participating pharmacists solved almost 3 of the 4 detected DRP's. In more than half of the DRP's, the patient was verbally and/or written informed. In 44% of the a posteriori discovered problems, the pharmacist intervened. CONCLUSION: Pharmacist detected one or more DRP's with 15% of the prescriptions. Analysis of a prescription prior to dispensing the medicines therefore appears necessary. The active intervention of the pharmacist in 83% of the problems indicates that he contributes to the optimization of drug therapy with a potential increase in the quality of life of the patient and a reduction in the cost of healthcare. The a posteriori discovered DRP's demonstrate the need for pharmacist lead meditation reviews possibly together with the physician and/or patient. [less ▲]

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See detailLectures de La Reine Albemarle ou le dernier touriste. Ontologie, autobiographie, politique
Cormann, Grégory ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(1),

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See detailLe medicament du mois. Bydureon: premier agoniste des recepteurs du GLP-1 en une injection hebdomadaire (exenatide a liberation prolongee).
Scheen, André ULg

in Revue medicale de Liege (2014), 69(4), 214-9

Bydureon is a new galenic formulation (long-acting release) of exenatide, the first agonist of Glucagon-Like Peptide-1 (GLP-1) receptors having been commercialized for the management of type 2 diabetes ... [more ▼]

Bydureon is a new galenic formulation (long-acting release) of exenatide, the first agonist of Glucagon-Like Peptide-1 (GLP-1) receptors having been commercialized for the management of type 2 diabetes. The microsphere technology permits a prolonged absorption of exenatide from the subcutaneous depot, which allows one injection per week instead of two injections per day with the initial formulation of exenatide (Byetta). The clinical development programme DURATION showed that exenatide 2 mg once weekly more markedly reduces glycated haemoglobin (HbA(1c)), with a similar weight loss but a better digestive tolerance profile (less nausea and vomiting after treatment initiation), compared with the twice daily 10 microg exenatide. When compared to other glucose-lowering agents, once weekly exenatide is more efficacious than sitagliptin, pioglitazone or basal insulin (glargine or detemir), with the advantage of producing weight loss and lowering arterial blood pressure. It does not induce hypoglycaemia and does not necessarily require home blood glucose monitoring, two advantages compared with insulin therapy. Bydureon is currently only reimbursed in Belgium after failure of and in addition to metformin-sulfonylurea combination. [less ▲]

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See detailStudy of residual stresses in bimetallic work rolls
Neira Torres, Ingrid ULg; Gilles, Gaëtan ULg; Tchuindjang, Jérôme Tchoufack ULg et al

in Advanced Materials Research (2014), 996

An experimental campaign of compression tests, differential thermal analysis (DTA), differential scanning calorimetry ( DSC), dilatometry and microstructure analysis has been performed, as well as the ... [more ▼]

An experimental campaign of compression tests, differential thermal analysis (DTA), differential scanning calorimetry ( DSC), dilatometry and microstructure analysis has been performed, as well as the identification of the material data set for finite element ( FE) analysis of bimetallic rolls. This article numerically investigates the stress and strain fields after the cooling stage and it checks their effect on the subsequent heat treatment step. As bimetallic rolls have a different material for core and shell, the effect of the roll size and the shell thickness on residual stresses is also studied. [less ▲]

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See detailNitroxide mediated polymerization of methacrylates at moderate temperature
Detrembleur, Christophe ULg; Jérôme, Christine ULg; De Winter, Julien et al

in Polymer Chemistry (2014), 5(2), 335-340

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide ... [more ▼]

In this communication we report the first homopolymerization of a variety of methacrylates by an NMP process at moderate temperature (40–50 °C), using an easily accessible and inexpensive nitroxide precursor. The combination of a low temperature azo-initiator with a hindered nitroso-compound produces a mixture of hindered nitroxides in the polymerization medium that act as efficient polymerization control agents. Results of Electron Spin Resonance (ESR) spectroscopy experiments combined with mass spectrometric studies support the proposed in situ NMP mechanism. The hindered structure of the nitroxides formed in situ is believed to be responsible for the efficiency of the process by allowing it to proceed at low temperature, therefore limiting the side reactions generally observed in NMP of methacrylates. [less ▲]

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See detailControl of citrus blue mold by the antagonist yeast Pichia guilliermondii Z1: compatibility with commercial fruit waxes and putative mechanisms of action.
Lahlali, Rachid; Hamadi, Younes; Drider, R. et al

in Food Control (2014), 45

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an ... [more ▼]

Pichia guilliermondii strain Z1, which was previously proven to be effective against blue mold of citrus fruit, has been further tested in controlled conditions to determine whether the yeast, as an alternative for synthetic fungicides, would be compatible with other postharvest practices used commercially. In particular, commercial fruit waxes can reduce their survival and effectiveness. The commercial fruit waxes tested, in combination at 20% with strain Z1, included microcrystalline, ester gum, candelilla, beeswax, montan, paraffin, rice bran, rosin maleic, carnauba, shellac, and one mixture shellac plus carnauba. Beeswax, paraffin, rosin maleic, carnauba, and shellac increased significantly strain Z1 survival in Petri dish assays. Candelilla, beeswax, rice bran, rosin maleic, carnauba, shellac, and shellacecarnauba mixture did not significantly reduce the strain Z1 yield on orange fruit surfaces compared to other waxes. With the exception of rosin maleic wax, none of the commercial fruit waxes or mixture increased significantly the ability of the formulated product of strain Z1 to control the postharvest pathogen Penicillium italicum on wounded orange fruit. When the formulated product of strain Z1 was used in combination with beeswax, strain Z1 retained the same efficacy. In contrast, microcrystalline, ester gum, candelilla, montan, paraffin, rice bran, carnauba, shellac, and shellac-carnauba mixture significantly reduced the effectiveness of the formulated product of strain Z1. No antibiosis was detected for strain Z1 against P. italicum. Strain Z1 inhibited the spore germination for the low juice concentration (up to 5%) when compared to the control. However, the addition of fresh juice after antagonist removal allowed the restoration of the germination of P. italicum spores; suggesting the possibility of competition for nutrients in the biocontrol activity of strain Z1. The study demonstrates the potential commercial application of strain Z1 with beeswax and rosin maleic wax for postharvest control of citrus blue mold. As biocontrol relies on competition for nutrients, an enriched formulation with nutrients is needed for reliable antifungal activity of this yeast strain [less ▲]

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See detailLearning in, through, and about participatory technology assessment: The case of nanotechnologies for tomorrow's society (NanoSoc)
Van Oudheusden, Michiel ULg

in Technology Analysis & Strategic Management (2014)

In participatory technology assessment (pTA), technical and nontechnical communities convene to share their views on a sociotechnical challenge, in an attempt to render technology research and development ... [more ▼]

In participatory technology assessment (pTA), technical and nontechnical communities convene to share their views on a sociotechnical challenge, in an attempt to render technology research and development more socially robust. Taking these commitments to transdisciplinary collaboration and co-construction of technology as entry points, this article describes key tensions that emerged in a Flemish pTA project on nanotechnologies, entitled ‘Nanotechnologies for Tomorrow’s Society’ (NanoSoc). The tensions pertain to how the terms of participation were enacted, the potentially conflicting aims embedded in the project’s mission and methods, the various roles initiating pTA researchers (social scientists) assumed throughout the project’s duration, and the deliberative-democratic rationale that sustains pTA frameworks at large. The article is a response to a pressing question posed to the author by pTA professionals, project participants, and policymakers who ask publics to partake in science and technology decision making: Now that NanoSoc is terminated, what can we learn from it? [less ▲]

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See detailA frontal approach to hex-dominant mesh generation
Baudouin, Tristan Carrier; Remacle, Jean-François; Marchandise, Emilie et al

in Advanced Modeling and Simulation in Engineering Sciences (2014), 1(1), 1-30

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See detailTowards targeted early burn care: lessons from a European survey.
ROUSSEAU, Anne-Françoise ULg; MASSION, Paul ULg; LAUNGANI, Alexis ULg et al

in Journal of Burn Care & Research (2014), 35

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See detailLa description des zones climatiques terrestres. À propos d’Ératosthène, Hermès, 16, 3-16 POWELL et Cicéron, Songe de Scipion, 21
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2014)

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See detailTravail sur Soi et justice réparatrice en prison: comptes rendus d'une mise en pratiques
Dubois, Christophe ULg; Vrancken, Didier ULg

in Sociologie et Sociétés (2014), 45(1), 249-273

Alors même que la prison se caractérise par des problèmes récurrents de surpopulation et d’indigence, une ambitieuse politique pénitentiaire, initiée en Belgique en l’an 2000, visait à orienter la culture ... [more ▼]

Alors même que la prison se caractérise par des problèmes récurrents de surpopulation et d’indigence, une ambitieuse politique pénitentiaire, initiée en Belgique en l’an 2000, visait à orienter la culture carcérale vers la « justice réparatrice ». Que dire, aujourd’hui, de cette tentative d’introduction en prison des notions de victime, de restauration de la relation perturbée, de responsabilisation et de sensibilisation ? La présente contribution propose d’abord un aperçu descriptif et illustratif de cette politique pénitentiaire, à travers deux comptes rendus de situations auxquelles elle a donné naissance. Ensuite, elle souligne le caractère innovant ainsi que les limites de cette politique de travail sur Soi qui, tissant autour du détenu un réseau d’intervenants multiples et de dispositifs participatifs, mobilise ses capacités réflexives et créatrices. [less ▲]

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See detailInsight into the development of a carbonate platform through a multi-disciplinary approach - A case study from the Upper Devonian slope deposits of Mount Freikofel (Carnic Alps, Austria/Italy)
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Suttner, Thomas et al

in International Journal of Earth Sciences (2014), 103

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental ... [more ▼]

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental changes that occur in geological past is still limited. We herein undertake a multi-disciplinary approach (sedimentology, conodont biostratigraphy, magnetic susceptibility and geochemistry) of a long-term succession in the Carnic Alps which offers new insights into the peculiar evolution of one of the best example of Palaeozoic carbonate platform in Europe. The Freikofel section, located in the central part of the Carnic Alps represents an outstanding succession in a fore-reef setting, extending from the latest Givetian (indet. falsiovalis conodont Zones) to the early Famennian (Lower crepida conodont Zone). Sedimentological analysis allowed to propose a sedimentary model dominated by distal slope and fore-reef slope deposits. The most distal setting is characterized by an autochthonous pelagic sedimentation showing local occurrence of thin-bedded turbiditic deposits. In the fore-reef slope, in a more proximal setting, there is an accumulation of various autochthonous and allochthonous fine- to coarse-grained sediments originated from the interplay of gravity-flow currents derived from the shallow-water and deeper-water area. The temporal evolution of microfacies in the Freikofel section evolves in two main steps corresponding to the Freikofel (Unit 1) and the Pal (Unit 2) Limestones. Distal slope to fore-reef lithologies and associate changes are from base to top of the section: (U1) thick bedded litho- and bioclastic breccia beds with local fining upward sequence and fine-grained mudstone intercalations corresponding, in the fore-reef setting, to the dismantlement of the Eifelian – Frasnian carbonate platform during the early to late Frasnian time (falsiovalis to rhenana superzones) with one of the causes being the Late Givetian major rift pulse; (U2) occurrence of thin-bedded red nodular and cephalopod-bearing limestones with local lithoclastic grainstone intercalations corresponding to a significant deepening of the area and the progressive withdrawal of sedimentary influxes toward the basin, in relation with late Frasnian sea-level rise. Magnetic susceptibility and geochemical analyses were also performed along the Freikofel section and demonstrate the inherent-parallel link existing between variation in magnetic susceptibility values and proxy for terrestrial input. Interpretation of magnetic susceptibility in term of palaeoenvironmental processes reflect that even though distality remains the major parameter influencing magnetic susceptibility values, carbonate production and water agitation also play an important role. [less ▲]

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See detailThe Role of the Renal Ammonia Transporter Rhcg in Metabolic Responses to Dietary Protein
Bounoure, Lisa; Ruffoni, Davide ULg; Mueller, Ralph et al

in JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014), 25(9), 2040-2052

High dietary protein imposes a metabolic acid load requiring excretion and buffering by the kidney. Impaired acid excretion in CKD, with potential metabolic acidosis, may contribute to the progression of ... [more ▼]

High dietary protein imposes a metabolic acid load requiring excretion and buffering by the kidney. Impaired acid excretion in CKD, with potential metabolic acidosis, may contribute to the progression of CKD. Here, we investigated the renal adaptive response of acid excretory pathways in mice to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA) and examined how this adaption requires the RhCG ammonia transporter. Diets rich in SAA stimulated expression of enzymes and transporters involved in mediating NH4+ reabsorption in the thick ascending limb of the loop of Henle. The SAA-rich diet increased diuresis paralleled by downregulation of aquaporin-2 (AQP2) water channels. The absence of Rhcg transiently reduced NH4+ excretion, stimulated the ammoniagenic pathway more strongly, and further enhanced diuresis by exacerbating the downregulation of the Na+/K+/2Cl(-) cotransporter (NKCC2) and AQP2, with less phosphorylation of AQP2 at serine 256. The high protein acid load affected bone turnover, as indicated by higher Ca2+ and deoxypyridinoline excretion, phenomena exaggerated in the absence of Rhcg. In animals receiving a high-protein diet with low SAA content, the kidney excreted alkaline urine, with low levels of NH4+ and no change in bone metabolism. Thus, the acid load associated with high-protein diets causes a concerted response of various nephron segments to excrete acid, mostly in the form of NH4+, that requires Rhcg. Furthermore, bone metabolism is altered by a high-protein acidogenic diet, presumably to buffer the acid load. [less ▲]

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See detailInfluence of domestication process on immune response to repeated emersion stressors in Eurasian perch (Perca fluviatilis L.)
Douxfils, Jessica; Lambert, S; Mathieu, Cédric et al

in Comparative Biochemistry and Physiology. A : Comparative Physiology (2014), 173

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See detailIdentification of 1-methyloctyl butanoate as the major sex pheromone component from females of the saddle gall midge, Haplodiplosis marginata (Diptera: Cecidomyiidae)
Censier, Florence ULg; Fischer, Christophe ULg; Laurent, Pascal et al

in Chemoecology (2014)

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective monitoring tool of saddle gall midge flights is needed in order to understand the enigmatic population dynamics of this pest, and to design an integrated management strategy. Therefore, volatile compounds emitted by females (alkan-2-ols and alk-2-yl butanoates) were identified, and the chirality of the emitted esters was determined to be the R absolute configuration. In field-trapping experiments, racemic non-2-yl butanoate attracted substantial numbers of H. marginata males. Thus, this compound will be useful in baited traps for monitoring seasonal flight patterns, and improving integrated management of the saddle gall midge in agricultural systems. [less ▲]

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See detailLa responsabilisation au service des "nouvelles" institutions de soin: institutions de soin, contractualisation
Robert, Jocelyne ULg; Djenane, Majid

in Revue de sciences économiques et de gestion (2014), 14

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See detailImpairment of symbiont photosynthesis increases host cell proliferation in the epidermis of the sea anemone Aiptasia pallida
Fransolet, David ULg; Roberty, Stéphane ULg; Plumier, Jean-Christophe ULg

in Marine Biology (2014)

Corals exposed to environmental stresses need to engage appropriate physiological strategies to survive. Here we examined tissue modifications following algal dysfunction. Aiptasia pallida was exposed ... [more ▼]

Corals exposed to environmental stresses need to engage appropriate physiological strategies to survive. Here we examined tissue modifications following algal dysfunction. Aiptasia pallida was exposed during one week to 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), the herbicide called Diuron. DCMU treatment produced a drastic loss in photosynthetic efficiency and a subsequent diminution of algae density over the following days. Cell proliferation evaluated by measuring the number of cells labeled with a thymidine analogue (EdU) revealed a significant increase in EdU+ cells in the epidermis after one week of DCMU incubation and in the gastrodermis at four weeks. TUNEL histology showed that the extent of cell death was however similar in the epidermis of control and treated specimens. In addition we noticed a significant effect of DCMU treatment on the density of epidermal mucocytes after one, two and four weeks. These results show that inhibition of Symbiodinium photosynthesis in the absence of any known direct effect of DCMU on host cells can induce an increase of epidermal host cell proliferation in both the epidermis and the gastrodermis. While new host gastrodermal cells are likely to promote tissue regeneration in order to recruit new algae, the new host epidermal cells may contribute to tissue adaptation following a decrease in energy income. Some of these new epidermal cells, such as mucocytes, may contribute to an eventual increase of the host heterotrophic ability until restoration of algal autotrophic contribution. [less ▲]

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See detailCyclic lipopeptides from Bacillus subtilis activate distinct patterns of defence responses in grapevine.
Farace, Giovanni; Fernandez, Olivier; Jacquens, Lucile et al

in Molecular plant pathology (2014)

Non-self-recognition of microorganisms partly relies on the perception of microbe-associated molecular patterns (MAMPs) and leads to the activation of an innate immune response. Bacillus subtilis produces ... [more ▼]

Non-self-recognition of microorganisms partly relies on the perception of microbe-associated molecular patterns (MAMPs) and leads to the activation of an innate immune response. Bacillus subtilis produces three main families of cyclic lipopeptides (LPs), namely surfactins, iturins and fengycins. Although LPs are involved in induced systemic resistance (ISR) activation, little is known about defence responses induced by these molecules and their involvement in local resistance to fungi. Here, we showed that purified surfactin, mycosubtilin (iturin family) and plipastatin (fengycin family) are perceived by grapevine plant cells. Although surfactin and mycosubtilin stimulated grapevine innate immune responses, they differentially activated early signalling pathways and defence gene expression. By contrast, plipastatin perception by grapevine cells only resulted in early signalling activation. Gene expression analysis suggested that mycosubtilin activated salicylic acid (SA) and jasmonic acid (JA) signalling pathways, whereas surfactin mainly induced an SA-regulated response. Although mycosubtilin and plipastatin displayed direct antifungal activity, only surfactin and mycosubtilin treatments resulted in a local long-lasting enhanced tolerance to the necrotrophic fungus Botrytis cinerea in grapevine leaves. Moreover, challenge with specific strains overproducing surfactin and mycosubtilin led to a slightly enhanced stimulation of the defence response compared with the LP-non-producing strain of B. subtilis. Altogether, our results provide the first comprehensive view of the involvement of LPs from B. subtilis in grapevine plant defence and local resistance against the necrotrophic pathogen Bo. cinerea. Moreover, this work is the first to highlight the ability of mycosubtilin to trigger an immune response in plants. [less ▲]

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See detailDeletion of exons 1-3 of the MEN1 gene in a large Italian family causes the loss of menin expression.
Zatelli, Maria Chiara; Tagliati, Federico; Di Ruvo, Mauro et al

in Familial cancer (2014)

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to ... [more ▼]

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disease, characterized by parathyroid adenomas, endocrine gastroenteropancreatic tumors and pituitary adenomas, due to inactivating mutations of the MEN1 gene (chromosome 11q13). MEN1 mutations are mainly represented by nonsense, deletions/insertions, splice site or missense mutations that can be detected by direct sequencing of genomic DNA. However, MEN1 patients with large heterozygous deletions may escape classical genetic screening and may be misidentified as phenocopies, thereby hindering proper clinical surveillance. We employed a real-time polymerase chain reaction application, the TaqMan copy number variation assay, to evaluate a family in which we failed to identify an MEN1 mutation by direct sequencing, despite a clear clinical diagnosis of MEN1 syndrome. Using the TaqMan copy number variation assay we identified a large deletion of the MEN1 gene involving exons 1 and 2, in three affected family members, but not in the other nine family members that were to date clinically unaffected. The same genetic alteration was not found in a group of ten unaffected subjects, without family history of endocrine tumors. The MEN1 deletion was further confirmed by multiplex ligation-dependent probe amplification, which showed the deletion extended from exon 1 to exon 3. This new approach allowed us to correctly genetically diagnose three clinical MEN1 patients that were previously considered as MEN1 phenocopies. More importantly, we excluded the presence of genetic alterations in the unaffected family members. These results underline the importance of using a variety of available biotechnology approaches when pursuing a genetic diagnosis in a clinically suggestive setting of inherited endocrine cancer. [less ▲]

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See detailDental occlusion influences knee muscular performances in asymptomatic females.
GROSDENT, Stéphanie ULg; O'Thanh, Roseline; Domken, Olivier et al

in Journal of strength and conditioning research / National Strength & Conditioning Association (2014), 28(2), 492498

Some authors claim that occlusal appliances can enhance athletic performance. Therefore this study investigated the influence of dental occlusion on knee muscle strength performance. Twelve healthy female ... [more ▼]

Some authors claim that occlusal appliances can enhance athletic performance. Therefore this study investigated the influence of dental occlusion on knee muscle strength performance. Twelve healthy female subjects (mean age 24.1 +/- 3.1 years) without temporomandibular joint dysfunction participated in this study. Isokinetic quadriceps and hamstring strength were assessed in relation to three randomized jaw conditions: mouth closed in maximum intercuspidation without splint, mouth closed on a balanced splint which optimized contact over the dental arch, mouth closed on a piece of resin of 1 mm which created an imbalanced occlusion. Tests were performed at 60 degrees /s and 240 degrees /s in concentric and 30 degrees /s in eccentric exertions. Concentric performances did not show any significant difference between the 3 jaw conditions (p > 0.05). By contrast, in the eccentric trials related to quadriceps performance, significant differences (p < 0.05) were observed between the resin condition and the two other modalities (without splint or with a balanced splint). The imbalanced occlusion created by the resin component corresponded to an average decrease of 9% in eccentric peak torque. The eccentric hamstring peak torques also showed a significant difference (p < 0.05) between measurements with splint and with resin (7% decrease when occlusion was imbalanced). In conclusion, among asymptomatic females, artificial imbalanced occlusion induces immediate and significant alteration of knee eccentric muscle performances. Therefore, occlusion examination should be undertaken on a regular and frequent basis for high-level athletes. Moreover, for athletes using mouthguards, muscular performance assessments should be planned with and without the dental protection. [less ▲]

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See detailMesozoic marine reptile palaeobiogeography in response to drifting plates
Bardet, Nathalie; Falconnet, Jocelyn; Fischer, Valentin ULg et al

in Gondwana Research (2014)

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically ... [more ▼]

During the Mesozoic, various groups of reptiles underwent a spectacular return to an aquatic life, colonizing most marine environments. They were highly diversified both systematically and ecologically, and most were the largest top-predators of the marine ecosystems of their time. The main groups were Ichthyosauria, Sauropterygia, Thalattosauria, and several lineages of Testudinata, Crocodyliformes, Rhynchocephalia and Squamata. Here we show that the palaeobiogeographical distribution of these marine reptiles closely followed the break-up of the supercontinent Pangaea and that they globally used the main marine corridors created by this break-up to disperse. Most Mesozoic marine reptile clades exhibit a cosmopolitan, or at least pandemic, distribution very early in their evolutionary history. The acquisition of morphological adaptations to a fully aquatic life, combined to special thermophysiological characteristics, are probably responsible for these animals to become efficient long-distance open-marine cruisers. Generally, Early Triassic taxa were near-shore animals mainly linked to the Tethys or Panthalassa coastlines. By the end of the Triassic and during the Jurassic, the break-up of Pangaea resulted in the formation of large marine corridors connecting the Tethys to the North Atlantic and Pacific realms, a trend increasing on during the Cretaceous with the expansion of the Atlantic Ocean and the break-up of the southern Gondwana, allowing open-sea marine reptiles to spread out over large distances. However, if large faunal interchanges were possible at a global scale following a dispersal model, some provinces, such as the Mediterranean Tethys, were characterized by a peculiar faunal identity, illustrating an absence of migration with time despite the apparent lack of barriers. So, if Continental Drift enabled global circulations and faunal interchanges via dispersals among Mesozoic marine reptiles, others parameters, such as ecological and biological constraints, probably also played a role in the local endemic distribution of some of these marine groups, as they do today. [less ▲]

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See detailLa Cour d'appel de Paris saisit l'Autorité de la Concurrence d'une demande d'avis pour apprécier le caractère prédateur d'un prix nul.
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2014), 1

GCUE, 16.10.13, Vivendi v. Commission, case T-432/10 The General Court of the European Union states that the Commission enjoys a wide margin of discretion when taking into account decisions and documents ... [more ▼]

GCUE, 16.10.13, Vivendi v. Commission, case T-432/10 The General Court of the European Union states that the Commission enjoys a wide margin of discretion when taking into account decisions and documents established by national regulators. [less ▲]

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See detailLa vignette diagnostique de l'etudiant. Diagnostic et evaluation d'une hypoglycemie chez le patient diabetique.
Scheen, André ULg

in Revue medicale de Liege (2014), 69(2), 110-5

Hypoglycaemic episodes are rather common among diabetic patients, especially those treated with sulfonylureas or insulin (more in type 1 than in type 2 diabetes). The presentation of hypoglycaemia may ... [more ▼]

Hypoglycaemic episodes are rather common among diabetic patients, especially those treated with sulfonylureas or insulin (more in type 1 than in type 2 diabetes). The presentation of hypoglycaemia may considerably vary from patient-to-patient and from time-to-time in a given patient. With the illustration of a clinical case, we will describe the characteristics of the three main types of hypoglycaemia: severe hypoglycaemia (with or without coma), symptomatic hypoglycaemia (with or without confirmation) and asymptomatic hypoglycaemia ("hypoglycaemia unawareness") discovered as a low blood glucose measurement. We will also briefly analyse the reasons of such differences and the potential clinical consequences that these three main types of hypoglycaemia may exert in the real life of diabetic patients. [less ▲]

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See detailCompte rendu de "Les enfants de Don Quichotte", P. Bruneeaux, Presses Universitaires de Vincennes, 2013
Frère, Bruno ULg

in Revue Française de Science Politique (2014), 64/2

Les enfants de Don Quichotte est un ouvrage qui présente intérêt non négligeable. Il s’agit de l’une des rares études sociologiques (la seule ?) portant sur un mouvement qui pourtant fit grand bruit dans ... [more ▼]

Les enfants de Don Quichotte est un ouvrage qui présente intérêt non négligeable. Il s’agit de l’une des rares études sociologiques (la seule ?) portant sur un mouvement qui pourtant fit grand bruit dans le monde médiatique et politique il y a quelques années : l’occupation des abords du canal Saint Martin par des SDF regroupés sous tentes. C’est délibérément que les auteurs de ce collectif ont choisi l’optique de la sociologie critique bourdieusienne pour enquêter. À ce titre, le parti pris épistémologique est de dévoiler les stratégies souvent inconscientes des protagonistes d’une part et de révéler d’autre part la persistance dans ce mouvement citoyen d’une forme de domination économique, culturelle et sociale qui maintient les SDF sous la tutelle d’une terrible violence symbolique. Cette violence symbolique est celle-là même qui, dans la théorie de Pierre Bourdieu, conduit les dominés à voir leur parole systématiquement censurée par les dominants. Cela jusque dans les dispositifs que les seconds, bien intentionnés, mettent sur pieds pour secourir les premiers. [less ▲]

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See detailStructural, magnetic and magneto-transport properties of monovalent doped manganite Pr0.55K0.05Sr0.4MnO3
Thaljaoui, R.; Boujelben, W.; Pękała, M. et al

in Journal of Alloys and Compounds (2014), 611(0), 427-432

Pr0.55K0.05Sr0.4MnO3 sample have been synthesized using the conventional solid state reaction. Rietveld refinements of the X-ray diffraction patterns at room temperature confirm that the sample is single ... [more ▼]

Pr0.55K0.05Sr0.4MnO3 sample have been synthesized using the conventional solid state reaction. Rietveld refinements of the X-ray diffraction patterns at room temperature confirm that the sample is single phase and crystallizes in the orthorhombic structure with Pnma space group; the crystallite size is around 70 nm. The SEM images show that grain size spreads around 1000–1200 nm. DTA analysis does not reveal any clear transition in temperature range studied. The low-temperature DSC indicates that Curie temperature is around 297 K. Magnetization measurements in a magnetic applied field of 0.01 T exhibit a paramagnetic–ferromagnetic transition at the Curie temperature TC = 303 K. A magnetic entropy change under an applied magnetic field of 2 T is found to be 2.26 J kg−1 K−1, resulting in a large relative cooling power around 70 J/kg. Electrical resistivity measurements reveal a transition from semiconductor to metallic phase. The thermal conductivity is found to be higher than that reported for undoped and Na doped manganites reported by Thaljaoui et al. (2013). [less ▲]

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See detailL’éjaculation précoce : une revue de questions
Kempeneers, Philippe ULg; ANDRIANNE, Robert ULg; Lequeux, Armand et al

in Revue Francophone de Clinique Comportementale et Cognitive (2014), 19(2), 35-60

Premature ejaculation (PE) is a disorder characterized by three components: (1) a rapid ejaculation, (2), a feeling of lack of control upon ejaculation, (3) and a distress related to this condition. The ... [more ▼]

Premature ejaculation (PE) is a disorder characterized by three components: (1) a rapid ejaculation, (2), a feeling of lack of control upon ejaculation, (3) and a distress related to this condition. The criterion of rapidity appears to be most controversial: some authors refer only to subjects’ judgment, while other ones set a maximum ejaculatory latency. Although it focused some criticisms related to a lack of objective latency criteria, the definition of PE propounded by the DSM-IV(-TR) remains most currently used. PE affects about 15 to 30% of the male population. However, the estimations can vary widely depending on populations and methodologies. Several factors contribute to the occurrence of the disorder: one may very probably charge bio-constitutional risks, learning factors, cultural and cognitive influences and the role of anxiety. No robust data allow to implicate personality factors other than anxiety. The influence of the age remains a controversial topic. Cognitive-behavioral techniques appear to be quite efficient in the treatment of PE. However the success rates are variable, and the precise nature of the therapeutic active process remains unclear. Serotonergic drugs and local anesthetics are also efficient, but their action remains strictly symptomatic. The usefulness of phosphodiesterase-5 inhibitors is disputed. Combining psychological and pharmacological approaches might be promising. Unfortunately, there is a lack of clinical trials in this field. Although effective treatments do exist, only a few affected people appear to use them satisfactorily. Efforts have still to be made in order to train adequately heath practitioners and to make the treatments more accessible to the public. [less ▲]

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See detailThe Rank Minrelation Coefficient
Meyer, Patrick ULg

in Quality Technology & Quantitative Management (2014), 11

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See detailInfluence de l'environnement et des pratiques culturales sur la productivité de Jatropha curcas L. en Afrique subsaharienne (synthèse bibliographique)
Minengu, Jean de Dieu; Mobambo, Patrick; Mergeai, Guy ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2), 290-300

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the ... [more ▼]

In most sub-Saharan African countries, the establishment of Jatropha curcas L. plantations preceded the scientific investigations necessary to optimize the production of this species. Consequently, the development of the plants was low and yields during the first years of cultivation were mostly disappointing. The low yields obtained in marginal conditions led to the belief that the cultivation of Jatropha could only be profitable in areas with fertile soils and sufficiently humid climates, which would place the plants in direct competition with food production. This article analyzes the available scientific knowledge regarding the ecological and technical factors influencing the productivity of J. curcas and suggests possible solutions for improving its performance in sub-Saharan Africa. [less ▲]

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See detailLA PHYSIQUE DES RADIATIONS IONISANTES POUR LES NEOPHYTES
LENAERTS, Eric ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 13-15

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès ... [more ▼]

Le développement clinique, à visée diagnostique et thérapeutique, des radiations ionisantes a nécessité une com - préhension de la physique. L’exploitation de ces connaissances a mené à des progrès majeurs en radiothérapie, visant à l’op - timisation de la distribution de la dose sur la cible et à l’exclu - sion, dans la mesure du possible, de l’irradiation des tissus sains avoisinants. Le développement de nouvelles modalités de traitement, telle l’utilisation des hadrons, est le reflet du développement de cette science. Aux confins de cette radio- physique se trouve la radiobiologie, et l’ensemble des connais - sances dans ces deux domaines permet une optimisation de la prescription médicale [less ▲]

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See detailThe Emergence of Antwerp as a Printing Centre. From Earliest Days of Printing to the Reformation (1481-1520)
Adam, Renaud ULg

in De Gulden Passer = Le compas d'or (2014), 92

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See detailGermanistik und Sprachlandschaft in Belgien
Küpper, Achim ULg

in Newsletter des Deutschen Germanistenverbands (2014), (1), 14-16

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See detailExtremely Organic-rich Coma of Comet C/2010 G2 (Hill) during its Outburst in 201
Kawakita, H; Dello Russo; Vervack, R et al

in Astrophysical Journal (2014)

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See detailPOWER PROCESSING UNIT ACTIVITIES AT THALES ALENIA SPACE BELGIUM
Bourguignon, Eric; Fraselle, Stéphane; Scalais, Thierry et al

in Proceedings of Space propulsion Conference 2014 (2014)

Since 1996, Thales Alenia Space Belgium (ETCA) designs, develops and produces Power Processing Unit (PPU) to supply Hall Effect Thrusters: SPT-100 from Fakel and PPS1350-G from Snecma. The first ... [more ▼]

Since 1996, Thales Alenia Space Belgium (ETCA) designs, develops and produces Power Processing Unit (PPU) to supply Hall Effect Thrusters: SPT-100 from Fakel and PPS1350-G from Snecma. The first qualification model, developed for the 50V bus Stentor program, has supplied during 8900 hours an SPT-100 thruster in a vacuum chamber simulating space environment. Qualified for the Spacebus 4000 platform, with a 100V regulated bus, the SB4000 PPU and Filter Unit EQM have cumulated 6300 hours ground operation with a PPS1350-G thruster. Twenty three PPU flight models were delivered for the Stentor, Astra-1K, Smart-1, Intelsat, Inmarsat, Eutelsat, Yahsat and DirecTV satellites. In October 2005, the Smart-1 spacecraft reached the Moon after 4958 hours of cumulated operation of the PPU with PPS1350-G thruster. Fourteen PPU’s currently in flight for North South Station Keeping on seven telecom satellites have cumulated more than 24100 hours flight operation. Following the selection of the PPS1350-G as baseline thruster for the AlphaBus platform, the Alphabus PPU was developed and two flight models were delivered for AlphaSat. Launched in July 2013, they have cumulated 350 hours operation. On the SmallGEO platform, one EPTA (Electric Propulsion Thruster Assembly) branch has to drive one out of four SPT-100 thrusters. As the PPU drives one out of two thrusters, TAS-B (ETCA) has developed and qualified an External Thruster Selection Unit (ETSU) to be associated to a PPU. Two flight sets (PPU+ETSU) were delivered for SmallGEO. In order to propose a more competitive product TAS-B (ETCA) has developed the new generation of PPU, called PPU Mk2, dedicated to Hall Effect Thrusters up to 2.5kW. The qualification phase is ending with the Qualification Test Review Board successfully hold in April 2014 and the final Qualification Review planned in June 2014. Twelve PPU Mk2 flight models are already ordered by two customers. In response to the market demand to use Electrical Propulsion for Orbit Raising, TAS-B (ETCA) has started the development of the PPU Mk3 dedicated to 5kW Hall Effect Thrusters. This paper presents an overview of the Power Processing Unit activities at TAS-B (ETCA), including flight heritage, PPU Mk2 qualification and the development of PPU Mk3. [less ▲]

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See detailAn air-lift biofilm reactor for the production of g-decalactones by Yarrowia lipolytica
Escamilla Garcia, E.; O’Riordan, S.; Gomes, N. et al

in Process Biochemistry (2014), 49

Decalactones are interesting flavouring compounds that can be produced from ricinoleic acid. In this study, the production of lactones in biofilms using Yarrowia lipolytica is investigated. The ... [more ▼]

Decalactones are interesting flavouring compounds that can be produced from ricinoleic acid. In this study, the production of lactones in biofilms using Yarrowia lipolytica is investigated. The hydrophobia of cells increased for increased aeration rates resulting in higher adhesion when the reactor wall was hydrophobic (plastic). To increase adhesion, sheets of methyl-polymethacrylate (PMMA) were added in the reactor and the production of lactones increased with the surface of plastic added, reaching 850 mg/L of 3-hydroxy- -decalactone for 60 cm2. In an Airlift bioreactor made of PMMA, biofilms were present at the top of the reactor for increased aeration. In the meantime, a metabolic shift occurred resulting in high amounts of 3-hydroxy- -decalactone. At 0.493 vvm and 61 h of culture, the dissolved oxygen ratio was of 28.6% and cells grew to only 1.29 × 106 cells/mL in the liquid medium but 3-hydroxy -decalactone accumulated to 1.7 g/L instead of less than 0.3 mg/L for lower aeration. Adhering cells had a particular elongated shape intermediate between the yeast and the pseudofilamentous forms. It is concluded that adhering Y. lipolytica cells are in a specific physiological state changing their structure but also their metabolic properties and these properties make them good candidate for simple immobilisation process. [less ▲]

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See detailMapping French terms in a Belgian guideline on heart failure to international classifications and nomenclatures: the devil is in the detail.
Jamoulle, Marc ULg; Cardillo, Elena; Roumier, Joseph et al

in Informatics in Primary Care (2014), accepted

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies ... [more ▼]

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies more stringent demands on the quality of data-entry at the point-of-care. Non-native English speaking general practitioners experience difficulties in interacting with international classification systems and nomenclatures to facilitate the secondary use of their data and to ensure semantic interoperability. Aim: To identify words and phrases pertaining to the heart failure domain and to explore the difficulties in mapping to corresponding concepts in ICPC-2, ICD-10, SNOMED-CT, and UMLS. Methods: The medical concepts in a Belgian guideline for General Practitioners (GPs) in its French version were extracted manually and coded first in ICPC-2, then ICD-10 by a physician, an expert in classification systems. In addition, mappings were sought with SNOMED-CT and UMLS concepts, using the UMLS SNOMED-CT browser. Results: We retained 143 words and phrases, of which 128 referred to a single concept (1-to-1 mapping), while 15 referred to 2 or more concepts (1-to-n mapping to ICPC rubrics or to the other nomenclatures). In the guideline, words or phrases were often too general for adequate correspondence. Marked discrepancy between semantic tags and types was found. Conclusion: This study illustrates the variability of the various international classifications and nomenclatures, the need for structured guidelines with more attention to precise wording, and the need for classification expertise embedded in sophisticated terminological resources. End-users need support to perform their clinical work in their own language, while still assuring standardized and semantic interoperable medical registration. Collaboration between computational linguists, knowledge engineers, health informaticians and domain experts is needed. [less ▲]

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See detailThe promise of wearable activity sensors to define patient recovery.
Appelboom, Geoff; Yang, Annie H.; Christophe, Brandon R. et al

in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2014), 21

The recent emergence of mobile health - the use of mobile telecommunication and wireless devices to improve health outcomes, services, and research - has inspired a patient-centric approach to monitor ... [more ▼]

The recent emergence of mobile health - the use of mobile telecommunication and wireless devices to improve health outcomes, services, and research - has inspired a patient-centric approach to monitor health metrics. Sensors embedded in wearable devices are utilized to acquire greater self-knowledge by tracking basic parameters such as blood pressure, heart rate, and body temperature as well as data related to exercise, diet, and psychological state. To that end, recent studies on utilizing wireless fitness activity trackers to monitor and promote functional recovery in patients suggest that collecting up-to-date performance data could help patients regain functional independence and help hospitals determine the appropriate length of stay for a patient. This manuscript examines existing functional assessment scales, discusses the use of activity tracking sensors in evaluating functional independence, and explores the growing application of wireless technology in measuring and promoting functional recovery. [less ▲]

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See detailPrognostic value of plasma B-type natriuretic peptide levels after exercise in patients with severe asymptomatic aortic stenosis.
Capoulade, Romain; Magne, Julien; Dulgheru, Raluca et al

in Heart (British Cardiac Society) (2014)

BACKGROUND: Exercise-stress echocardiography is useful in management and risk stratification of patients with asymptomatic aortic stenosis (AS). Resting B-type natriuretic peptide (BNP) level is ... [more ▼]

BACKGROUND: Exercise-stress echocardiography is useful in management and risk stratification of patients with asymptomatic aortic stenosis (AS). Resting B-type natriuretic peptide (BNP) level is associated with increased risk of adverse events. The incremental prognostic value of BNP response during exercise is unknown. OBJECTIVE: The purpose of this study was to assess the usefulness of plasma level of BNP during exercise to predict occurrence of events in asymptomatic patients with severe AS. METHODS: Resting and exercise-stress echocardiographic data and plasma BNP levels were prospectively collected in 211 asymptomatic AS patients in whom 157 had severe AS with preserved LVEF in two centres. The study end-point was the occurrence of death or aortic valve replacement. RESULTS: Plasma BNP level increased from rest to exercise (p<0.0001). During a mean follow-up of 1.5+/-1.2 years, 87 patients with severe AS reached the predefined end-point. Higher peak-exercise BNP level was associated with higher occurrence of adverse events (p<0.0001). In multivariate analysis, second and third tertiles of peak-exercise BNP (T2: HR=2.9; p=0.002 and T3: HR=5.3; p<0.0001, respectively) were powerful predictors of events compared with the first tertile. Further adjustment for resting BNP provided comparable results (T2: HR=2.8; p=0.003 and T3: HR=5.0; p<0.0001). This relationship persisted in both subsets of patients with low or high resting BNP. CONCLUSIONS: This study reports that peak-exercise BNP level provides significant incremental prognostic value beyond what is achieved by demographic and echocardiographic data, as well as resting BNP level. [less ▲]

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See detailThe political choices of emigrants voting in home country elections: A socio-political analysis of the electoral behaviour of Bolivian external voters
Lafleur, Jean-Michel ULg; Sanchez-Dominguez, Maria

in Migration Studies (2014)

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this ... [more ▼]

What variables influence the electoral behaviour of citizens voting in home country elections from abroad? Despite the growing interest of migration scholars for the topic of external voting, this question remains largely unanswered. Basing ourselves on the existing political science literature on electoral behaviour and on the migration literature on immigrants’ participation in host country politics, we isolate different hypotheses that explain emigrants’ preferences in home country politics. We then build four models of voters based on these hypotheses: the social group voter, the ideological voter, the interest-driven voter, and the transnational voter. In the second part of the paper, we verify the validity of these models using the results of a survey carried out with Bolivian emigrants who took part in the 2009 Bolivian presidential election from abroad. Overall, this article identifies the drivers of immigrant transnational political participation and contributes to current debates on social remittances. [less ▲]

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See detailThree species for the price of one within the moss Homalothecium sericeum s.l.
Hedenäs, Lars; Desamore, Aurélie ULg; Laenen, Benjamin ULg et al

in Taxon (2014), 63

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See detailGouvy/Bovigny : empierrement à Courtil "Obourcy"
Drailly, Christelle; Thiebaux, Aurélie ULg; Goemaere, Eric

in Chronique de l'Archéologie Wallonne (2014), 21

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See detailEvent-triggered transmission for linear control over communication channels
Forni, Fulvio ULg; Galeani, Sergio; Nesic, Dragan et al

in Automatica (2014), 50(2), 490498

We consider an exponentially stable closed loop interconnection of a continuous linear plant and a continuous linear controller, and we study the problem of interconnecting the plant output to the ... [more ▼]

We consider an exponentially stable closed loop interconnection of a continuous linear plant and a continuous linear controller, and we study the problem of interconnecting the plant output to the controller input through a digital channel. We propose a family of "transmission-lazy" sensors whose goal is to transmit the measured plant output information as little as possible while preserving closed-loop stability. In particular, we propose two transmission policies, providing conditions on the transmission parameters. These guarantee global asymptotic stability when the plant state is available or when an estimate of the state is available (provided by a classical continuous linear observer). Moreover, under a specific condition, they guarantee global exponential stability [less ▲]

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See detailContrasting patterns of phytoplankton communities in two coastal ecosystems in relation to environmental factors (Corsica, NW Mediterranean Sea)
Garrido, Marie; Koeck, Barbara; Goffart, Anne ULg et al

in Diversity (2014), 6

Corsica Island is a sub-basin of the Northwestern Mediterranean Sea, with hydrological features typical of both oligotrophic systems and eutrophic coastal zones. Phytoplankton assemblages in two coastal ... [more ▼]

Corsica Island is a sub-basin of the Northwestern Mediterranean Sea, with hydrological features typical of both oligotrophic systems and eutrophic coastal zones. Phytoplankton assemblages in two coastal ecosystems of Corsica (the deep Bay of Calvi and the shallow littoral of Bastia) show contrasting patterns over a one-year cycle. In order to determine what drives these variations, seasonal changes in littoral phytoplankton are considered together with environmental parameters. Our methodology combined a survey of the physico-chemical structure of the subsurface water with a characterization of the phytoplankton community structure. Sampling provided a detailed record of the seasonal changes and successions that occur in these two areas. Results showed that the two sampled stations presented different phytoplankton abundance and distribution patterns, notably during the winter–spring bloom period. Successions in pico-, nano-, and microphytoplankton communities appeared mainly driven by differences in the ability to acquire nutrients, and in community-specific growth rates. Phytoplankton structure and dynamics are discussed in relation to available data on the Northwestern Mediterranean Sea. These results confirm that integrated monitoring of coastal areas is a requisite for gaining a proper understanding of marine ecosystems. [less ▲]

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See detailRobot-assisted laparoscopy for deep infiltrating endometriosis: international multicentric retrospective study.
Collinet, Pierre; Leguevaque, Pierre; Neme, Rosa Maria et al

in Surgical Endoscopy (2014), sous presse

BACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April ... [more ▼]

BACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April 2012, 164 women with stage 4 endometriosis who underwent robot-assisted laparoscopy (da Vinci Intuitive Surgical System) were included by to eight international participating clinical centers. This study evaluated the procedures performed, the duration of the intervention, the complications, the recurrence, and the impact on fertility. RESULTS: The average operative time was 180 min. The main complications were laparotomy (n = 1, 0.6 %), sutured bowel injury (n = 2, 1.2 %), transfusion for a 2,300-ml bleed (n = 1), prolonged urinary catheterization (n = 1, 0.6 %), ureter-bladder anastomotic leak (n = 1, 0.6 %), and ureteral fistula after ureterolysis (n = 2, 1.2 %). The reoperation rate was 1.8 % (n = 3). The mean follow-up period was 10.2 months. A full recovery was experienced by 86.7 % (98/113) of the patients. After surgery, 41.2 % (42/102) of the patients had a desire for pregnancy, and 28.2 % (11/39) of them became pregnant. CONCLUSION: This study analyzed the largest series of robot-assisted laparoscopies for deep infiltrating endometriosis published in the literature. No increase in surgical time, blood loss, or intra- or postoperative complications was observed. The interest in robot-assisted laparoscopy for deep infiltrating endometriosis seems to be promising. [less ▲]

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See detailPhysical Characterization Methods for Supplementary Cementitious Materials.
Arvaniti, Eleni; Juenger, Maria; Bernal, Susan et al

in Materials and Structures (2014)

The main supplementary cementitious materials (SCMs) that are used today are industrial by-products. In most cases the quality of these materials cannot be controlled during their production, resulting in ... [more ▼]

The main supplementary cementitious materials (SCMs) that are used today are industrial by-products. In most cases the quality of these materials cannot be controlled during their production, resulting in materials with varied characteristics. The adequate physical characterization of SCMs is important to better predict their performance and optimize their use in concretes production. There are standardized methods used to determine the particle characteristics for Portland cements that are usually adopted to characterize SCMs; however, these methods may not be as accurate when applied to SCMs. This paper is an overview of the techniques that are currently used for the determination of the density, particle size distribution, surface area and shape of SCMs. The main principles of each method are presented. The limitations that occur for the SCMs measurements are also discussed. This paper is an output from the work of the RILEM Technical Committee on Hydration and Microstructure of Concrete with Supplementary Cementitious Materials (TC-238-SCM). [less ▲]

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See detailThe evaluation of vocal pitch accuracy: The case of operatic singing voices
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Music Perception (2014), 32(1), 1-10

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices ... [more ▼]

The objective analysis of Western operatic singing voices indicates that professional singers can be particularly “out of tune”. This study aims to better understand the evaluation of operatic voices, which have particularly complex acoustical signals. Twenty-two music experts were asked to evaluate the vocal pitch accuracy of 14 sung performances with a pairwise comparison paradigm, in a test and a retest. In addition to the objective measurement of pitch accuracy (pitch interval deviation), several performance parameters (average tempo, fundamental frequency of the starting note) and quality parameters (energy distribution, vibrato rate and extent) were observed and compared to the judges’ perceptual rating. The results show high intra- and inter-judge reliability when rating the pitch accuracy of operatic singing voices. Surprisingly, all the parameters were significantly related to the ratings and explain 78.8% of the variability of the judges’ rating. The pitch accuracy evaluation of operatic voices is thus not based exclusively on the precision of performed music intervals but on a complex combination of performance and quality parameters. [less ▲]

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See detailApplication of heparin as a dual agent with antimalarial and nanocapsule targeting activity towards Plasmodium-infected red blood cells
Marques, J.; Moles, E.; Urbán, P. et al

in Nanomedicine (2014)

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See detailWhen the value of gold is zero.
Chase, J. Geoffrey; Moeller, Knut; Shaw, Geoffrey M. et al

in BMC research notes (2014), 7

This manuscript presents the concerns around the increasingly common problem of not having readily available or useful "gold standard" measurements. This issue is particularly important in critical care ... [more ▼]

This manuscript presents the concerns around the increasingly common problem of not having readily available or useful "gold standard" measurements. This issue is particularly important in critical care where many measurements used in decision making are surrogates of what we would truly wish to use. However, the question is broad, important and applicable in many other areas.In particular, a gold standard measurement often exists, but is not clinically (or ethically in some cases) feasible. The question is how does one even begin to develop new measurements or surrogates if one has no gold standard to compare with?We raise this issue concisely with a specific example from mechanical ventilation, a core bread and butter therapy in critical care that is also a leading cause of length of stay and cost of care. Our proposed solution centers around a hierarchical validation approach that we believe would ameliorate ethics issues around radiation exposure that make current gold standard measures clinically infeasible, and thus provide a pathway to create a (new) gold standard. [less ▲]

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See detailCharacterization and Adsorption Study of Thymol on Pillared Bentonite
El Miz, Mohamed; Salhi, S.; Chraibi, I. et al

in Open Journal of Physical Chemistry (2014), 4(3), 98-116

Pillared clay (PILC) was prepared from Moroccan clay and characterized, and its aqueous thymol adsorption capacities were studied using a batch equilibrium technique. So, we tested the encapsulation of ... [more ▼]

Pillared clay (PILC) was prepared from Moroccan clay and characterized, and its aqueous thymol adsorption capacities were studied using a batch equilibrium technique. So, we tested the encapsulation of thymol by aluminum pillared clay (PILC). The PILCs displayed a total surface area of 270 m2/g, a total pore volume of 0.246 cm3/g and an average pore diameter of 8.9 Å, which corresponds to the size of Al13 forming the pillars between the clay layers. The adsorption capacity shown by the PILCs for thymol from water is close to 319 mg∙g−1 for low solid/liquid ratio (0.2%). This result suggests that the PILCs have both hydrophobic and hydrophilic characteristics, as a result of the presence of silanol and siloxane groups formed during the pillaring and calcination of the PILCs. The experimental data were analyzed by the Freundlich and the Langmuir isotherm types for low values of equilibrium concentration. The rise of the isotherm in this range of concentrations was related to the affinity of thymol for clay sites, and the equilibrium data fitted well with the Freundlich model with maximum adsorption capacity of 319.51 mg/g for a ratio RS/L = 0.2%. Pseudo-first and pseudo-second-order kinetic models were tested with the experimental data and pseudo-first order kinetics was the best for the adsorption of thymol with coefficients of correlation R² ≥0.986, and the adsorption was rapid with 90% of the thymol adsorbed within the first 20 min. [less ▲]

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See detailEffets de deux associations culturales avec du blé sur les populations de pucerons (Homoptera: Aphididae) et d’auxiliaires aphidiphages: étude préliminaire menée en Chine
Chevalier Mendes Lopes, Thomas ULg; Bosquée, Emilie ULg; Honba, David et al

in Entomologie Faunistique = Faunistic Entomology (2014)

Crop associations have several advantages when the plant species and the crop production methods, including the harvesting, are well selected. This preliminary study was conducted in the Shandong province ... [more ▼]

Crop associations have several advantages when the plant species and the crop production methods, including the harvesting, are well selected. This preliminary study was conducted in the Shandong province (China) to better characterize the effect of wheat (Triticum aestivum L.)/oilseed rape (Brassica napus L.) and wheat/pea (Pisum sativum L.) associations on the aphid and aphidophagous beneficial populations. Aphids observed on wheat tillers were more abundant in the pure stand of wheat during the two weeks prior to their population peak, compared with crop associations. Considering the aphidophagous beneficials, more ladybirds were observed in the associations, compared with the pure crop stand. Yellow pan traps were also used to assess the diversity and abundance of adult beneficial species. The parasitoid species Aphidius gifuensis (Ashmead) was prevalent. Among predators, Propylea japonica (Thunberg) and Harmonia axyridis (Pallas) were the most abundant species. This study contributes to better understand the potential of crop associations with wheat as a sustainable method to control aphid populations in this region of China. [less ▲]

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See detailL’« originalité » perceptive d’un sujet pervers au test de Rorschach
Englebert, Jérôme ULg

in Evolution Psychiatrique (2014), 79(3), 429-441

The author starts with a discussion about two notions appearing into the Rorschach test: the perception and the apperception. By this way, it is suggest ways for a phenomenological study of the Rorschach ... [more ▼]

The author starts with a discussion about two notions appearing into the Rorschach test: the perception and the apperception. By this way, it is suggest ways for a phenomenological study of the Rorschach test. These proposals are consistent with those of the Comprehensive System (Proposed by John E. Exner). Then the author proposes a protocol analyzing of a patient with a perverse psychological functioning. In one hand, the result obtained by the Form Quality (FQ) is detailed in particular regarding to the status of unusual perceptions. According to the Comprehensive System proposed by J.E. Exner, a significant proportion of responses "u" (46% for this protocol) indicates that the person is not influenced by any social request or any expectation and some of his behaviors could ignore or avoid any question about social convention. From an other point of view, when analyzing these data, an adaptive dimension for these unusual perceptions is identified. The pervert perceives the stimuli that "really exists" according to him not everyone can perceive it. This advantage allows a better adaptation to the environment and the ability to change this environment. The manipulation (a particular skill that is most of the time attributed to the perverse person) is probably a consequence of having an original perception of reality. It is also discussed the interpretation of the "anatomical content" in connection with this adaptive hypothesis. In addition, the author also discusses a particular answer of the protocol: the answer "shoes" that presents a specific perceptual characteristic. [less ▲]

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See detailL'électroneuromyographie dans la pathologie de la face dorsale du pied
WANG, François-Charles ULg

in Médecine et Chirurgie du Pied = Foot Medicine and Surgery (2014), (30), 86-89

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See detailFrench adaptation and validation of the SinoNasal Outcome Test (SNOT)-22: a prospective cohort study on quality of life among 422 subjects.
de Dorlodot, Clotilde; Horoi, Mihaela; Lefèbvre, Philippe ULg et al

in Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2014)

OBJECTIVES: ENT surgeons are facing an ever-increasing demand to demonstrate their efficacy. The 22-item Sino-Nasal Outcome Test (SNOT-22) is a fully validated and easy-to-use outcome measure in rhinology ... [more ▼]

OBJECTIVES: ENT surgeons are facing an ever-increasing demand to demonstrate their efficacy. The 22-item Sino-Nasal Outcome Test (SNOT-22) is a fully validated and easy-to-use outcome measure in rhinology. Our goal was to translate and validate the SNOT-22 in a cohort of 422 French-speaking subjects. DESIGN, SETTING AND PARTICIPANTS: The French version of the SNOT-22 was obtained by forward and backward translations by 6 independent interpreters. Five experienced rhinologists compared the translations to each other and a group of 12 naive patients selected the most appropriate translation of each item. To evaluate this questionnaire, we conducted a prospective cohort study on 376 rhinological patients and 46 healthy volunteers in 3 University-affiliated teaching Hospitals. MAIN OUTCOME MEASURES: reproducibility (test-retest reliability), internal consistency, known group differences, responsiveness to treatment, validity and correlation to other clinical instruments (visual analogue scale, Nasal Obstruction Symptoms Evaluation score and Lund-Mackay score). RESULTS: The test-retest reliability coefficient was 0.78, indicating a good reliability when administering the instrument on two different occasions. The internal consistency was high with a Cronbach's alpha value of 0.93. Our questionnaire was able to detect differences between rhinological patients and control subjects (p<0.0001) and improved significantly after nose and sinus surgery (p<0.0001), indicating a good responsiveness. There was a relative correlation with visual analogue scale and NOSE score, but no correlation with Lund-Mackay score. CONCLUSION: The SNOT-22 is a reliable and valid tool to assess quality of life in French-speaking patients and correlates well with known indices of disease severity. This article is protected by copyright. All rights reserved. [less ▲]

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See detailEvaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2014)

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 ... [more ▼]

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Areas covered: An extensive literature search was performed to analyze the pharmacokinetic characteristics, toxicological issues and safety concerns of SGLT2 inhibitors in humans. This review focuses on three compounds (dapagliflozin, canagliflozin, empagliflozin) with results obtained in healthy volunteers (including drug-drug interactions), patients with T2DM (single dose and multiple doses) and special populations (those with renal or hepatic impairment). Expert opinion: The three pharmacological agents share an excellent oral bioavailability, long half-life allowing once-daily administration, low accumulation index and renal clearance, the absence of active metabolites and a limited propensity to drug-drug interactions. No clinically relevant changes in pharmacokinetic parameters were observed in T2DM patients or in patients with mild/moderate renal or hepatic impairment. Adverse events are a slightly increased incidence of mycotic genital and rare benign urinary infections. SGLT2 inhibitors have the potential to reduce several cardiovascular risk factors, and cardiovascular outcome trials are currently ongoing. The best positioning of SGLT2 inhibitors in the armamentarium for treating T2DM is still a matter of debate. [less ▲]

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See detailA one phase thermomechanical model for the numerical simulation of semi-solid material behavior. Application to thixoforming
Koeune, Roxane; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2014), 58

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called ... [more ▼]

This work deals with the development of an appropriate constitutive model for semi-solid thixoforming processes of metallic alloys. These processes rely on a very specific material behavior called thixotropy that can be displayed by some metallic alloys heated up to their semi-solid state. It is a particular evolutionary behavior which is characterized by a solidlike behavior at rest and a liquid flow during shearing, thus by a decrease of the viscosity and of the resistance to deformation while sheared. An original one-phase thermo-elasto-viscoplastic constitutive model has been developed. The basic idea is to extend the classical isotropic hardening and viscosity models beyond the solid state by considering two more non-dimensional internal scalar parameters. The semi-solid state is treated as a particular case, and one of the main features of the proposed constitutive model is that it remains valid over a wide range of temperatures, starting from room temperature to above the liquidus in a continuous manner, thus allowing a continuous transition between classical solid and fluid behavior. Another feature is that, after the forming step, it is possible to simulate the cooling down of the component back to room temperature using the elastic–viscoplastic model. So it is possible to estimate residual stresses, something that is definitely impossible while using a fluid-like model or a rigid viscoplastic approach. The presented model is illustrated and validated by means of representative numerical applications, as two different extrusion tests are carried out and the computed predictions are compared to experimental results. [less ▲]

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See detailWhich incretin-based therapy for type 2 diabetes?
Scheen, André ULg

in Lancet (2014)

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See detailFocus cardiac ultrasound: the European Association of Cardiovascular Imaging viewpoint.
Neskovic, Aleksandar N.; Edvardsen, Thor; Galderisi, Maurizio et al

in European heart journal cardiovascular Imaging (2014)

The concept of point-of-care, problem-oriented focus cardiac ultrasound examination (FoCUS) is increasingly applied in the settings of medical emergencies, including cardiac diseases. The European ... [more ▼]

The concept of point-of-care, problem-oriented focus cardiac ultrasound examination (FoCUS) is increasingly applied in the settings of medical emergencies, including cardiac diseases. The European Association of Cardiovascular Imaging (EACVI) recognizes that cardiologists are not the only medical professionals dealing with cardiovascular emergencies. In reality, emergency cardiac diagnostics and treatment are also carried out by a wide range of specialists. For the benefit of the patients, the EACVI encourages any medical professional, sufficiently trained to obtain valuable information from FoCUS, to use it in emergency settings. These medical professionals need to have the necessary knowledge to understand the obtained information entirely, and to use it correctly, thoughtfully and with care. In this document, the EACVI underlines major differences between echocardiography and FoCUS, and underscores the need for specific education and training in order to fully utilize advantages and minimize drawbacks of this type of cardiac ultrasound examination in the critically ill patients. [less ▲]

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See detailMobilisation of lipophilic pollutants from blubber in northern elephant seal pups (Mirounga angustirostris) during the post-weaning fast
Louis, Caroline; Dirtu, Alin C.; Stas, Marie et al

in Environmental Research (2014), 132

Northern elephant seals (NES) (Mirounga angustirostris) from the Año Nuevo State Reserve (CA, USA) were longitudinally sampled during the post-weaning fast in order to study the mobilisation and ... [more ▼]

Northern elephant seals (NES) (Mirounga angustirostris) from the Año Nuevo State Reserve (CA, USA) were longitudinally sampled during the post-weaning fast in order to study the mobilisation and redistribution of various classes of persistent organic pollutants (POPs), such as polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p′-DDE) and hexachlorobenzene (HCB) between blubber and blood. Inner and outer blubber layers were analysed separately. Organohalogenated compounds were detected in all blubber samples in the decreasing order of their concentrations: p,p′-DDE>PCBs⪢HCB>PBDEs. The concentrations of all studied compounds were homogeneously distributed in the blubber layer at early fast, since the concentrations of POPs were statistically not different in the inner and outer layers. With the progression of the fast, the concentrations of PBDEs, PCBs and p,p′-DDE increased more sharply in inner blubber than in outer blubber. As a result, their levels became significantly higher in inner blubber as compared to outer blubber at late fast. The rise of pollutant concentrations in blubber might result from a less efficient mobilisation than triglycerides and/or a reuptake by adipocytes of some of the pollutants released into the circulation. The mobilisation of pollutants from blubber was higher at late fast. An increase of pollutant concentrations was observed in serum between early and late fast. Lower halogenated congeners (i.e. tetra-CBs) were present in higher proportions in serum, whereas the higher halogenated congeners (i.e. hepta-CBs) were mainly found in the inner and outer blubber layers. The transfer ratios of both PBDEs and PCBs from inner blubber to serum decreased with the number of chlorine and bromine atoms. In addition, the distribution of both types of compounds between serum and blubber was strongly influenced by their lipophilic character (log Kow values), with more lipophilic compounds being less efficiently released from blubber to serum. [less ▲]

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See detailVaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.
Gutierrez, Geronimo; Rodriguez, Sabrina M.; De Brogniez, Alix ULg et al

in Viruses (2014), 6(6), 2416-2427

Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly ... [more ▼]

Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy. [less ▲]

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See detailPsychopathologie, alimentation et sexualité
Desseilles, Martin; Kempeneers, Philippe ULg

in Sexualités Humaines : Revue de Sexologie des Professionnels de Santé (2014), 22

L'alimentation et la sexualité entretiennent des liens de réciprocité principalement indirects tant dans les premiers stades de développement psychosexuel de l'individu que dans les mécanismes ... [more ▼]

L'alimentation et la sexualité entretiennent des liens de réciprocité principalement indirects tant dans les premiers stades de développement psychosexuel de l'individu que dans les mécanismes physiologiques ou physiopathologiques. Dans cet article nous passerons en revue ces interrelations en essayant d'y apporter un éclairage nuancé et clinique [less ▲]

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See detailMagritte y Wittgenstein : acuerdo y desacuerdo
Badir, Sémir ULg

in Tópicos del Seminario (2014), 30

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See detailPharmacotherapie du sujet agee: primum non nocere!
Scheen, André ULg

in Revue medicale de Liege (2014), 69(5-6), 282-6

Elderly patients, having various chronic diseases, are generally exposed to polypharmacy that may lead to potential adverse events. The latter may be explained by pharmacokinetic and pharmacodynamic ... [more ▼]

Elderly patients, having various chronic diseases, are generally exposed to polypharmacy that may lead to potential adverse events. The latter may be explained by pharmacokinetic and pharmacodynamic particularities that render elderly individuals more vulnerable when exposed to certain medications. Recruitment of elderly patients in clinical trials is often limited, so that it is not always easy to determine the real benefit/risk ratio of pharmacotherapy in this population. Obviously, iatrogenicity is quite frequent. Therefore, in front of unexplained alterations of health status in an elderly individual, the physician should consider the possibility of a drug adverse effect. Because of this situation, the physician should envisage a reasonable drug prescription in an elderly patient. Especially, not only the initiation of drug therapy should be carefully analyzed, but also the opportunity to eventually stop a medication that may be useless or even dangerous. Rather polypharmacy per se, it is the inappropriate prescription that should be avoided in the elderly. [less ▲]

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See detail"Je ne connais pas Ben Sadok". La genèse écrite du témoignage de Sartre au procès Ben Sadok
Cormann, Grégory ULg; Bourgault, Jean

in Genesis (2014), 39

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See detailAssessment of Solvent Degradation within a Global Process Model of Post-Combustion CO2 Capture
Léonard, Grégoire ULg; Toye, Dominique ULg; Heyen, Georges ULg

in Computer Aided Chemical Engineering (2014), 33

Solvent degradation may be a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. However, its influence on the ... [more ▼]

Solvent degradation may be a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. However, its influence on the process operations has rarely been studied. In the present work, a kinetics model describing solvent oxidative and thermal degradation has been developed based on own experimental results for the benchmark solvent, i.e. 30 wt% monoethanolamine (MEA) in water. This model has been included into a global Aspen Plus model of the CO2 capture process. The selected process modelling approaches are described in the present work. Using the resulting simulation model, optimal operating conditions can be identified to minimize both the energy requirement and the solvent degradation in the process. This kind of process model assessing solvent degradation may contribute to the design of large-scale CO2 capture plants to consider not only the process energy penalty, but also its environmental penalty. Indeed, both aspects are relevant for the large-scale deployment of the CO2 capture technology. [less ▲]

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See detailMaria Davis. El humor en las novelas de Gabriel García Márquez
Vanden Berghe, Kristine ULg

in Bulletin of Spanish Studies (2014), 91(6), 956-957

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See detailLa vignette diagnostique de l'étudiant. Diagnostic et évolution d'une gale.
Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2014), 69

Human scabies is an ectoparasitosis affecting any individual at any age. The level of infestation by Sarcoptes scabiei var. hominis is influenced by any defect in immune response. Several clinical types ... [more ▼]

Human scabies is an ectoparasitosis affecting any individual at any age. The level of infestation by Sarcoptes scabiei var. hominis is influenced by any defect in immune response. Several clinical types of scabies are described including baby scabies, profuse scabies of immunodepression, norvegian scabies and sarcoptic mange. Onchocerciasis dermatitis is a tropical microfilariosis completely distinct by its parasitIc nature. [less ▲]

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See detailCyanoacrylate skin surface strippings and the 3S-Bioket advent in tropical dermatology. A look from Liège.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; PAQUET, Philippe ULg et al

in Scientific World Journal (The) (2014), 2014

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named ... [more ▼]

In the dermatopathology field, some simple available laboratory tests require minimum equipment for establishing a diagnosis. Among them, the cyanoacrylate skin surface stripping (CSSS), formerly named skin surface biopsy or follicular biopsy, represents a convenient low cost procedure. It is a minimally invasive method collecting a continuous sheet of stratum corneum and horny follicular casts. In the vast majority of cases, it is painless and is unassociated with adverse events. CSSS can be performed in subjects of any age. The method has a number of applications in diagnostic dermatopathology and cosmetology, as well as in experimental dermatology settings. A series of derived analytic procedures include xerosis grading, comedometry, corneofungimetry, corneodynamics of stratum corneum renewal, corneomelametry, corneosurfametry, and corneoxenometry. [less ▲]

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See detailA propos de l'encéphalopathie du nouveau-né
Battisti, Oreste ULg; Beguin, Yves ULg

in Percentile (2014), 19

Editorial sur l'hypoxie périnatale et les cellules souches.

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See detailTeriparatide Therapy for Denosumab-Induced Osteonecrosis of the Jaw in a Male Osteoporotic Patient.
Neuprez, Audrey; Rompen, Eric ULg; Crielaard, Jean-Michel ULg et al

in Calcified tissue international (2014), 95

We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a male subject with idiopathic osteoporosis. Clinical benefits and CT healing ... [more ▼]

We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a male subject with idiopathic osteoporosis. Clinical benefits and CT healing were obtained within 2 months of teriparatide initiation and denosumab withdrawal. Increase in bone turnover previously described, when denosumab treatment is removed, might have a synergistic effect to the stimulating effect of teriparatide on bone remodeling to promptly heal osteonecrosis of the jaw. [less ▲]

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See detailElectrochemical Investigation of Nitinol/Tantalum Hybrid Surfaces Modified by Alkylphosphonic Self-Assembled Monolayers
Maho, Anthony ULg; Kanoufi, Frédéric; Combellas, Catherine et al

in Electrochimica Acta (2014), 116(0), 78-88

The surface characteristics of bare and modified nickel-titanium samples (NiTi) are investigated by spectroscopic, microscopic and electrochemical techniques. The successful electrodeposition of a ... [more ▼]

The surface characteristics of bare and modified nickel-titanium samples (NiTi) are investigated by spectroscopic, microscopic and electrochemical techniques. The successful electrodeposition of a tantalum coating on NiTi and the effective grafting of 1-dodecylphosphonic acid SAMs on both pristine and Ta-covered NiTi surfaces are evidenced and quantified by XPS and SEM. Cyclic voltammetry performed on the different NiTi-based electrodes highlights their specificities regarding electron transfer to a redox probe present in solution (here ruthenium(III) hexamine). Finally, the samples electrochemical characteristics at a local scale are investigated by scanning electrochemical microscopy (SECM). The impact of the surface modifications on mass transport of the redox probe is analyzed through approach curves in the feedback mode, while the recording of current maps in feedback as well as in substrate-generation/tip-collection modes leads to the qualitative identification of electrochemically-active areas corresponding to precursor pitting corrosion sites. [less ▲]

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See detailTRAITEMENT CONSERVATEUR DES CANCERS INFILTRANTS DE LA VESSIE
WERENNE, Xavier ULg; COUCKE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 69-74

Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement ... [more ▼]

Le cancer de la vessie occupe la 9ème place en termes de fréquence, voire la 2 ème chez la personne âgée, et se situe juste après celui de la prostate. La cystectomie est actuelle- ment le traitement «standard» des cancers infiltrants de la vessie. Cependant, elle est liée à un taux élevé de complications et à une altération de la qualité de vie, en particulier, chez les patients âgés présentant de nombreuses comorbidités. Le but de cet article est de déterminer les alternatives conservatrices et de préciser à quels patients elles doivent être réservées, en particulier, l’approche trimodale (résection trans-uréthrale et radio-chimiothérapie) et la cystectomie partielle précédée de radio-chimiothérapie [less ▲]

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See detailcompte rendu de : Maria Chiara SCAPPATICCIO, Accentus, distinctio, apex. L’accentazione grafica tra Grammatici Latini e papiri virgiliani
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2014)

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See detailMulti-scale modeling of mycosubtilin lipopeptides at the air/water interface: structure and optical second harmonic generation
Loison, Claire; Nasir, Mehmet Nail ULg; Benichou, Emmanuel et al

in Physical Chemistry Chemical Physics [=PCCP] (2014), 16

Monolayers of the lipopeptide mycosubtilin are studied at the air/water interface. Their structure is investigated using molecular dynamics simulations. All-atom models suggest that the lipopeptide is ... [more ▼]

Monolayers of the lipopeptide mycosubtilin are studied at the air/water interface. Their structure is investigated using molecular dynamics simulations. All-atom models suggest that the lipopeptide is flexible and aggregates at the interface. To achieve simulation times of several microseconds, a coarse-grained (CG) model based on the MARTINI force field was also used. These CG simulations describe the formation of half-micelles at the interface for surface densities up to 1 lipopeptide per nm2. In these aggregates, the tyrosine side chain orientation is found to be constrained: on average, its main axis, as defined along the C–OH bond, aligns along the interface normal and points towards the air side. The origin of the optical second harmonic generation (SHG) from mycosubtilin monolayers at the air/water interface is also investigated. The molecular hyperpolarizability of the lipopeptide is obtained from quantum chemistry calculations. The tyrosine side chain contribution to the hyperpolarizability is found to be dominant. The orientation distribution of tyrosine, associated with a dominant hyperpolarizability component along the C–OH bond of the tyrosine, yields a ratio of the susceptibility elements χ(2)ZZZ/χ(2)ZXX consistent with the experimental measurements recently reported by M. N. Nasir et al. [Phys. Chem. Chem. Phys., 2013, 15, 19919]. [less ▲]

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See detailVOC emissions and protein expression mediated by the interactions between herbivorous insects and Arabidopsis plant. A review
Hien, Truong Thi Dieu ULg; Heuskin, Stéphanie ULg; Delaplace, Pierre ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(3), 455-464

Herbivorous insects, such as phloem-sap feeders and chewers, induce resistance response in plants. There is a long-standing hypothesis that herbivores increase the emission of volatile organic compounds ... [more ▼]

Herbivorous insects, such as phloem-sap feeders and chewers, induce resistance response in plants. There is a long-standing hypothesis that herbivores increase the emission of volatile organic compounds (VOCs) in the Arabidopsis plant model. However, most works were restricted to the study of the regulation of plant VOC emissions and only in some cases to the effects of insects on such emissions. Often these investigations do not establish a link between quantitative and qualitative emission of plant VOCs with actual damages caused by insects. Moreover, information remain limited about the processes that occur at the protein level encoded of the host plant under stress conditions. Here, we briefly summarize the effects of specific chewing and phloem-sap feeding insects on the emission of VOCs by Arabidopsis thaliana Col-0, and review some predictions about pathogenesis-related proteins, based on current evolutionary hypotheses. Further investigation of the effects of herbivorous insects on VOC emissions and protein expression is expected to improve our knowledge about their patterns and functions in plant responses to stresses. [less ▲]

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See detailMapping Diasporic Subjectivities
Munos, Delphine ULg; Pandurang, Mala

in South Asian Diaspora (2014), 6(1),

The last two decades have witnessed a growing interest in theorizing literary narratives that address the South Asian diasporic experience. By and large, however, what has emerged is an academic consensus ... [more ▼]

The last two decades have witnessed a growing interest in theorizing literary narratives that address the South Asian diasporic experience. By and large, however, what has emerged is an academic consensus which accords an ever-greater visibility to mainstream diasporic voices from North America, U.K., some parts of Africa and of the Caribbean, at the expense of narratives dealing with South Asian diasporic communities that are based in other locations. Also, such critical consensus valorizes certain class-streamed patterns of migration over others, with the result of homogenizing the diversity of today’s South Asian diaspora. This special issue explores literary representations of the migrant experiences of those underrepresented South Asian communities based in locations such as South America, East Europe, the Gulf, West Africa and East Asia. [less ▲]

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See detailClosure to “Parapet Wall Effect on Piano Key Weir Efficiency”
Erpicum, Sébastien ULg; Machiels, Olivier; Pirotton, Michel ULg et al

in Journal of Irrigation & Drainage Engineering (2014)

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See detailAider à vivre, aider à mourir
Jamoulle, Marc ULg

in Pratiques : les Cahiers de la Médecine Utopique (2014), 66

Aider à vivre et aider à mourir ne sont pas tellement éloignés l’un de l’autre en médecine de famille. Au quotidien, la différence est tranchée et la limite claire. Il y a les vivants et il y a les morts ... [more ▼]

Aider à vivre et aider à mourir ne sont pas tellement éloignés l’un de l’autre en médecine de famille. Au quotidien, la différence est tranchée et la limite claire. Il y a les vivants et il y a les morts. Pas si sûr. Entre vie et mort, le fil est parfois ténu. [less ▲]

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See detailInsights into oxygen transport and net community production in sea ice from oxygen, nitrogen and argon concentrations
Zhou, Jiayun ULg; Delille, Bruno ULg; Brabant, F. et al

in Biogeosciences (2014), 11

We present the evolution of O2 standing stocks, saturation levels and concentrations in landfast sea ice, collected in Barrow (Alaska), from February to June 2009. The comparison of the standing stocks ... [more ▼]

We present the evolution of O2 standing stocks, saturation levels and concentrations in landfast sea ice, collected in Barrow (Alaska), from February to June 2009. The comparison of the standing stocks and saturation levels of O2 against those of N2 and Ar suggests that the dynamic of O2 in sea ice strongly depends on physical processes (gas incorporation and subsequent transport). We then discuss on the use of O2 / Ar and O2 / N2 to correct for the physical contribution and to determine the biological contribution (NCP) to O2 supersaturations. We conclude that O2 / Ar suits better than O2 / N2, because O2 / N2 is more sensitive due to the relative abundance of O2, N2 and Ar, and less biased when gas bubble formation and gas diffusion are maximized. We further estimate the NCP in the impermeable layers during ice growth and in the permeable layers during ice decay. Our results indicate that NCP contributed to a~release of carbon to the atmosphere in the upper ice layers, but to an uptake of carbon at sea ice bottom. Overall, seawater (rather than the atmosphere) may be the main supplier of carbon for sea ice microorganisms. [less ▲]

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See detailLéopold Auguste Warnkönig et François Laurent Pionniers des Universités de Liège et Gand
Gerkens, Jean-François ULg

in Revue de la Faculté de Droit de l'Université de Liège (2014), (1), 157-171

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See detailIntegration of inland waterway transport in the intermodal supply chain: a taxonomy of research challenges
Caris, An; Limbourg, Sabine ULg; Macharis, Cathy et al

in Journal of Transport Geography (2014), 41

This paper identifies research opportunities which will enable the further integration of inland waterway transport in the intermodal supply chain. Intermodal transport may be interpreted as a chain of ... [more ▼]

This paper identifies research opportunities which will enable the further integration of inland waterway transport in the intermodal supply chain. Intermodal transport may be interpreted as a chain of actors who supply a transport service. Inland navigation can play a crucial role in increasing supply chain service performance. A first group of research challenges lies in the evolving relationship between transport geography and logistics activities. The next set of research challenges has the objective to encourage efficient operations in IWT: development of a system wide model for IWT, integration of operational planning systems and analysis of bundling networks. A third group of research efforts is directed towards shippers and consignees who use the intermodal transport chain to send or receive their goods: further development of models that integrate intermodal transport decisions with supply chain decisions and creation of green supply chains. A fourth cluster of research challenges concerns the problem domain of external cost calculations. Finally detailed time series data on freight transport should be collected to support these future research tracks? [less ▲]

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See detailquelques messages choisis de l'ECCO 17
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2014), 8(1), 8-11

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See detailContrasting biogeochemical characteristics of the Oubangui River and tributaries (Congo River basin)
Bouillon, Steven; Yambélé, Athanase; Gillikin, David P. et al

in Scientific Reports (2014), 4

The Oubangui is a major tributary of the Congo River. We describe the biogeochemistry of contrasting tributaries within its central catchment, with watershed vegetation ranging from wooded savannahs to ... [more ▼]

The Oubangui is a major tributary of the Congo River. We describe the biogeochemistry of contrasting tributaries within its central catchment, with watershed vegetation ranging from wooded savannahs to humid rainforest. Compared to a 2-year monitoring record on the mainstem Oubangui, these tributaries show a wide range of biogeochemical signatures, from highly diluted blackwaters (low turbidity, pH, conductivity, and total alkalinity) in rainforests to those more typical for savannah systems. Spectral analyses of chromophoric dissolved organic matter showed wide temporal variations in the Oubangui compared to spatio-temporal variations in the tributaries, and confirm that different pools of dissolved organic carbon are mobilized during different hydrological stages. d13C of dissolved inorganic carbon ranged between -28.1 per mil and -25.8 per mil, and was strongly correlated to both partial pressure of CO2 and to the estimated contribution of carbonate weathering to total alkalinity, suggesting an important control of the weathering regime on CO2 fluxes. All tributaries were oversaturated in dissolved greenhouse gases (CH4, N2O, CO2), with highest levels in rivers draining rainforest. The high diversity observed underscores the importance of sampling that covers the variability in subcatchment characteristics, to improve our understanding of biogeochemical cycling in the Congo Basin. [less ▲]

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See detailEarly detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model.
MORIMONT, Philippe ULg; Pironet, Antoine ULg; Desaive, Thomas ULg et al

in Medical engineering & physics (2014)

AIMS: The time constant of left ventricular (LV) relaxation derived from a monoexponential model is widely used as an index of LV relaxation rate, although this model does not reflect the non-uniformity ... [more ▼]

AIMS: The time constant of left ventricular (LV) relaxation derived from a monoexponential model is widely used as an index of LV relaxation rate, although this model does not reflect the non-uniformity of ventricular relaxation. This study investigates whether the relaxation curve can be better fitted with a "quadratic" model than with the "conventional" monoexponential model and if changes in the LV relaxation waveform due to acute myocardial ischemia could be better detected with the quadratic model. METHODS AND RESULTS: Isovolumic relaxation was assessed with quadratic and conventional models during acute myocardial ischemia performed in 6 anesthetized pigs. Mathematical development indicates that one parameter (Tq) of the quadratic model reflects the rate of LV relaxation, while the second parameter (K) modifies the shape of the relaxation curve. Analysis of experimental data obtained in anesthetized pigs showed that the shape of LV relaxation consistently deviates from the conventional monoexponential decay. During the early phase of acute myocardial ischemia, the rate and non-uniformity of LV relaxation, assessed with the quadratic function, were significantly enhanced. Tq increased by 16% (p<0.001) and K increased by 12% (p<0.001) within 30 and 60min, respectively, after left anterior descending (LAD) coronary artery occlusion. However, no significant changes were observed with the conventional monoexponential decay within 60min of ischemia. CONCLUSIONS: The quadratic model better fits LV isovolumic relaxation than the monoexponential model and can detect early changes in relaxation due to acute myocardial ischemia that are not detectable with conventional methods. [less ▲]

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See detailRelationships between rapid changes in local aromatase activity and estradiol concentrations in male and female quail brain.
Dickens, M. J.; de Bournonville, C.; Balthazart, Jacques ULg et al

in Hormones and behavior (2014), 65(2), 154-164

Estradiol-17beta (E2) synthesized in the brain plays a critical role in the activation of sexual behavior in many vertebrate species. Because E2 concentrations depend on aromatization of testosterone ... [more ▼]

Estradiol-17beta (E2) synthesized in the brain plays a critical role in the activation of sexual behavior in many vertebrate species. Because E2 concentrations depend on aromatization of testosterone, changes in aromatase enzymatic activity (AA) are often utilized as a proxy to describe E2 concentrations. Utilizing two types of stimuli (sexual interactions and acute restraint stress) that have been demonstrated to reliably alter AA within minutes in opposite directions (sexual interactions=decrease, stress=increase), we tested in Japanese quail whether rapid changes in AA are paralleled by changes in E2 concentrations in discrete brain areas. In males, E2 in the pooled medial preoptic nucleus/medial portion of the bed nucleus of the stria terminalis (POM/BST) positively correlated with AA following sexual interactions. However, following acute stress, E2 decreased significantly (approximately 2-fold) in the male POM/BST despite a significant increase in AA. In females, AA positively correlated with E2 in both the POM/BST and mediobasal hypothalamus supporting a role for local, as opposed to ovarian, production regulating brain E2 concentrations. In addition, correlations of individual E2 in POM/BST and measurements of female sexual behavior suggested a role for local E2 synthesis in female receptivity. These data demonstrate that local E2 in the male brain changes in response to stimuli on a time course suggestive of potential non-genomic effects on brain and behavior. Overall, this study highlights the complex mechanisms regulating local E2 concentrations including rapid stimulus-driven changes in production and stress-induced changes in catabolism. [less ▲]

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See detailThe Clinical Utilisation of Respiratory Elastance Software (CURE Soft): a bedside software for real-time respiratory mechanics monitoring and mechanical ventilation management.
Szlavecz, Akos; Chiew, Yeong Shiong; Redmond, Daniel et al

in Biomedical engineering online (2014), 13(1), 140

BACKGROUND: Real-time patient respiratory mechanics estimation can be used to guide mechanical ventilation settings, particularly, positive end-expiratory pressure (PEEP). This work presents a software ... [more ▼]

BACKGROUND: Real-time patient respiratory mechanics estimation can be used to guide mechanical ventilation settings, particularly, positive end-expiratory pressure (PEEP). This work presents a software, Clinical Utilisation of Respiratory Elastance (CURE Soft), using a time-varying respiratory elastance model to offer this ability to aid in mechanical ventilation treatment. IMPLEMENTATION: CURE Soft is a desktop application developed in JAVA. It has two modes of operation, 1) Online real-time monitoring decision support and, 2) Offline for user education purposes, auditing, or reviewing patient care. The CURE Soft has been tested in mechanically ventilated patients with respiratory failure. The clinical protocol, software testing and use of the data were approved by the New Zealand South Regional Ethics Committee. RESULTS AND DISCUSSION: Using CURE Soft, patient's respiratory mechanics response to treatment and clinical protocol were monitored. Results showed that the patient's respiratory elastance (Stiffness) changed with the use of muscle relaxants, and responded differently to ventilator settings. This information can be used to guide mechanical ventilation therapy and titrate optimal ventilator PEEP. CONCLUSION: CURE Soft enables real-time calculation of model-based respiratory mechanics for mechanically ventilated patients. Results showed that the system is able to provide detailed, previously unavailable information on patient-specific respiratory mechanics and response to therapy in real-time. The additional insight available to clinicians provides the potential for improved decision-making, and thus improved patient care and outcomes. [less ▲]

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