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See detailCharacterization of Black locust (Robinia pseudoacacia L.) heartwood extractives: identification of resveratrol and piceatannol
Sergent, Thérèse; Kohnen, Stéphane; Jourez, Benoît ULg et al

in Wood Science and technology (2014)

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less ... [more ▼]

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less durability against fungi decay, which could be attributed to lower extractive content. In order to elucidate this idea, extractives from mature and juvenile heartwoods of black locust trees were investigated. Results showed that extractive and phenolic contents were higher in mature than in juvenile heartwoods. The identification of phenolic compounds by UPLC–DAD–MS/MS revealed, for the first time, the presence of resveratrol and piceatannol. These two stilbenes as well as the flavonoid dihydrorobinetin were present at the highest level in mature heartwood, and as they are known antifungals, they could account for the great durability of mature heartwood. The stilbenes were detected in significant amounts particularly in mature heartwood where piceatannol reached a level tenfold higher than that reported for Japanese knotweed roots, the primary natural source of these stilbenes, whereas resveratrol level was comparable with reported values. As resveratrol and piceatannol receive increasing demand for nutraceutical, cosmetic and, possibly, pharmaceutical purposes, due to their beneficial health effects, this study underlines the use of R. pseudoacacia as a promising sustainable and economical source of resveratrol and piceatannol. [less ▲]

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See detailEffect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages.
Koppenol, A.; Delezie, E.; Aerts, J. et al

in Poultry science (2014), 93(3), 564-73

When added to the feed of broiler breeder hens, dietary polyunsaturated fatty acids (FA) can be incorporated into the yolk and therefore become available to the progeny during their early development. The ... [more ▼]

When added to the feed of broiler breeder hens, dietary polyunsaturated fatty acids (FA) can be incorporated into the yolk and therefore become available to the progeny during their early development. The mechanism involved in lipid metabolism and deposition in the egg may be influenced by breeder age. Before the effect of an elevated concentration of certain polyunsaturated FA on the embryo can be investigated, the effect at breeder level and egg quality must be further assessed. The aim of the present experiment was to evaluate the effects of dietary n-6/n-3 ratios and dietary eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) ratios, provided to broiler breeder hens, in terms of their zoo technical performance, egg quality, and yolk FA composition. Starting at 6 wk of age, 640 Ross-308 broiler breeder hens were fed 1 of 4 different diets. The control diet was a basal diet, rich in n-6 FA. The 3 other diets were enriched in n-3 FA, formulated to obtain a different EPA/DHA ratio of 1/1 (EPA = DHA), 1/2 (DHA), or 2/1 (EPA). In fact, after analysis the EPA/DHA ratio was 0.8, 0.4, or 2.1, respectively. Dietary EPA and DHA addition did not affect the performance of the breeder hens, except for egg weight. Egg weight was lower (P < 0.001) for all n-3 treatments. Dietary EPA improved number of eggs laid in the first 2 wk of the production cycle (P = 0.029). The absolute and relative yolk weight of eggs laid by EPA = DHA fed hens was lowest (P = 0.004 and P = 0.025, respectively). The EPA and DHA concentrations in the yolk were highly dependent on dietary EPA and DHA concentrations with a regression coefficient equal to 0.89. It can be concluded that dietary EPA and DHA can be incorporated in the breeder egg yolk to become available for the developing embryo, without compromising the performance and egg quality of the flock. [less ▲]

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See detailThe mitochondrial respiratory chain of the secondary green alga Euglena gracilis shares many additional subunits with parasitic Trypanosomatidae.
Perez, Emilie ULg; Lapaille, Marie; Degand, Herve et al

in Mitochondrion (2014)

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential ... [more ▼]

The mitochondrion is an essential organelle for the production of cellular ATP in most eukaryotic cells. It is extensively studied, including in parasitic organisms such as trypanosomes, as a potential therapeutic target. Recently, numerous additional subunits of the respiratory-chain complexes have been described in Trypanosoma brucei and Trypanosoma cruzi. Since these subunits had apparently no counterparts in other organisms, they were interpreted as potentially associated with the parasitic trypanosome lifestyle. Here we used two complementary approaches to characterise the subunit composition of respiratory complexes in Euglena gracilis, a non-parasitic secondary green alga related to trypanosomes. First, we developed a phylogenetic pipeline aimed at mining sequence databases for identifying homologs to known respiratory-complex subunits with high confidence. Second, we used MS/MS proteomics after two-dimensional separation of the respiratory complexes by Blue Native- and SDS-PAGE to both confirm in silico predictions and to identify further additional subunits. Altogether, we identified 41 subunits that are restricted to E. gracilis, T. brucei and T. cruzi, along with 48 classical subunits described in other eukaryotes (i.e. plants, mammals and fungi). This moreover demonstrates that at least half of the subunits recently reported in T. brucei and T. cruzi are actually not specific to Trypanosomatidae, but extend at least to other Euglenozoa, and that their origin and function are thus not specifically associated with the parasitic lifestyle. Furthermore, preliminary biochemical analyses suggest that some of these additional subunits underlie the peculiarities of the respiratory chain observed in Euglenozoa. [less ▲]

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See detailThe relationship between working memory for serial order and numerical development: a longitudinal study
Attout, Lucie ULg; Noël, Marie-Pascale; Majerus, Steve ULg

in Developmental Psychology (2014), 50(6), 1667-1679

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See detailMonitoring batch lipase catalyzed interesterification of palm oil and fractions by differential scanning calorimetry
Danthine, Sabine ULg; DeClercq, Nathalie; Dewettinck, Koen et al

in Journal of Thermal Analysis and Calorimetry (2014)

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See detailThe anorectic effects of alpha-lipoicacid are mediated by central AMPK and are not due to taste aversion in chicken (Gallus gallus)
Wang, Y.; Song, Z.; Everaert, Nadia ULg et al

in Physiology & Behavior (2014), 132

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See detailEndogenous Altruism, Redistribution, and Long Term Care
Pestieau, Pierre ULg; Cremer, Helmuth; Gahvari, Firouz

in B.E. Journal of Economic Analysis & Policy (2014), 14(2), 499-524

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See detailEssai de synthèse de rôles de l'élevage pastoral au Sahel et en Afrique de l'Ouest
Laouali, Abdoulkadri ULg; Yamba, Boubacar; Chabi Toko, Roukayath et al

in Annales de l'Université Abdou Moumouni de Niamey, Série B Lettres et Sciences Humaines (2014), Numéro spécial

Throughout the world, livestock plays an important role in socio-economic life and dietary balance of the population especially in the Sahel and West Africa countries characterized by extensive pastoral ... [more ▼]

Throughout the world, livestock plays an important role in socio-economic life and dietary balance of the population especially in the Sahel and West Africa countries characterized by extensive pastoral farming. Across the literature, this activity appears to be subjected to various controversies including its contribution to the degradation of the environment; greenhouse gas emissions; its low economic performance; etc. This article attempts to state the debate through a literature review showing the importance of pastoral livestock in the economics of the Sahel and West Africa countries as well as in household alimentation and the fight against poverty. Also, it noticed the importance and efficiency of pastoral practice in a precariously natural environment such as the Sahel area [less ▲]

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See detailYBa2Cu3O7-δ thick films for magnetic shielding: Electrophoretic deposition from butanol-based suspension
Closset, Raphaël ULg; Kumar, Devendra; Wera, Laurent ULg et al

in Materials Letters (2014), 119

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common ... [more ▼]

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common acetone-iodine combination. Tests with several dispersing agents reveal that a branched polyethyleneimine (PEI) dispersant develops large positive surface charge on suspended YBCO particles. As a demonstration of the performance of this new suspension formulation, a 12-layer 100 μm-thick YBCO coating was deposited on an Ag tube. The superconducting transition is sharp with onset critical temperature at 92 K. The sample can shield a magnetic field of ~1.3 mT at 77 K, i.e., the best value so far for an YBCO coating on a metallic substrate. © 2013 Elsevier B.V. [less ▲]

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See detailIntroduction aux problèmes inverses
Charles, Catherine ULg

in Notes de Statistique et d'Informatique (2014)

cette note technique est une inititation aux problèmes inverses. Son objectif est d'expliquer au lecteur ses principes généraux, de montrer son large panel d'applications ainsi que de présenter ses ... [more ▼]

cette note technique est une inititation aux problèmes inverses. Son objectif est d'expliquer au lecteur ses principes généraux, de montrer son large panel d'applications ainsi que de présenter ses méthodes de résolution les plus courantes. [less ▲]

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See detailEnhancing a CH-pi interaction to increase the affinity for 5-HT1A receptors
Liégeois, Jean-François ULg; Lespagnard, Marc; Meneses Salas, Elsa et al

in ACS Medicinal Chemistry Letters (2014), 5

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6 ... [more ▼]

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6-tetrahydropyridine (THP) analogue compared to the corresponding 4-phenylpiperazine analogue. To explore a possible reinforcement of this interaction to increase the affinity for 5-HT1A receptors, different 4-substituted-phenyl analogues were synthesized and tested. The most important increase of affinity is obtained with two electron-donating methyl groups in position 3 and 5 [less ▲]

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See detailLe myélome multiple asymptomatique : le paysage thérapeutique change
CAERS, Jo ULg; BEGUIN, Yves ULg

in Oncol. Hematol. (2014), 8

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade ... [more ▼]

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade précurseur du myélome multiple. En moyenne, les patients présentant un myélome asymptomatique ont un risque annuel de progression en myélome déclaré de 10%. Différents facteul"s ont été combinés dans des modélisations pronostiques: le rapport des chaînes légères, les anomalies radiologiques, la présence d'une gammapathie évolutive et l'infiltration médullaire > 60% ont récemment été identifiés comme facteurs prédictifs d'une progression précoce pour lesquels certains auteurs évoquent la mise en roùte d'un traitement anti-myélome. Cette stratégie thérapeutique précoce a démontré son efficacité dans une étude randomisée qui comparait un traitement par lénalidornide et dexaméthasone avec une approche attentiste chez des patients à risque. [less ▲]

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See detailGlobal comparison of light use efficiency models for simulating terrestrial vegetation gross primary production based on the LaThuile database
Yuan, W.; Cai, W.; Xia, J. et al

in Agricultural and Forest Meteorology (2014), 192-193

Simulating gross primary productivity (GPP) of terrestrial ecosystems has been a major challenge in quantifying the global carbon cycle. Many different light use efficiency (LUE) models have been ... [more ▼]

Simulating gross primary productivity (GPP) of terrestrial ecosystems has been a major challenge in quantifying the global carbon cycle. Many different light use efficiency (LUE) models have been developed recently, but our understanding of the relative merits of different models remains limited. Using CO2 flux measurements from multiple eddy covariance sites, we here compared and assessed major algorithms and performance of seven LUE models (CASA, CFix, CFlux, EC-LUE, MODIS, VPM and VPRM). Comparison between simulated GPP and estimated GPP from flux measurements showed that model performance differed substantially among ecosystem types. In general, most models performed better in capturing the temporal changes and magnitude of GPP in deciduous broadleaf forests and mixed forests than in evergreen broadleaf forests and shrublands. Six of the seven LUE models significantly underestimated GPP during cloudy days because the impacts of diffuse radiation on light use efficiency were ignored in the models. CFlux and EC-LUE exhibited the lowest root mean square error among all models at 80% and 75% of the sites, respectively. Moreover, these two models showed better performance than others in simulating interannual variability of GPP. Two pairwise comparisons revealed that the seven models differed substantially in algorithms describing the environmental regulations, particularly water stress, on GPP. This analysis highlights the need to improve representation of the impacts of diffuse radiation and water stress in the LUE models. © 2014 Elsevier B.V. [less ▲]

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See detailPolitical Participation of Latin American Migrants in Andalusia: Opportunities and Constraints
Bermudez Torres, Anastasia ULg; Escriva, Angeles; Moraes, Natalia

in Migraciones Internacionales (2014), 7(3), 73-98

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The ... [more ▼]

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The project uses a broad concept of what political participation constitutes, including both civic practices and activities associated with conventional politics, and adopts a transnational perspective. It is based on 45 semi-structured interviews with politically active migrants and members of political parties and other institutions. The article highlights some of the main findings of the research, including the importance of taking into account migrants’ previous political experiences, as well as the role played by migrant associations in order to better understand their political practices. [less ▲]

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See detailEuroEcho-Imaging 2013: highlights.
Lancellotti, Patrizio ULg; Magne, Julien ULg; Cosyns, Bernard et al

in European Heart Journal - Cardiovascular Imaging (2014), 15(5), 483-488

The annual meeting of the European Association of Echocardiography (EuroEcho-Imaging) was held in Istanbul, Turkey. In the present paper, we present a summary of the 'Highlights' session.

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See detailAmantadine, Apomorphine and Zolpidem in the Treatment of Disorders of Consciousness
Gosseries, Olivia ULg; Charland-Verville, Vanessa ULg; Thonnard, Marie ULg et al

in Current Pharmaceutical Design (2014), 20

Survivors of severe brain injuries may end up in a state of 'wakeful unresponsiveness' or in a minimally conscious state. Pharmacological treatments of patients with disorders of consciousness aim to ... [more ▼]

Survivors of severe brain injuries may end up in a state of 'wakeful unresponsiveness' or in a minimally conscious state. Pharmacological treatments of patients with disorders of consciousness aim to improve arousal levels and recovery of consciousness. We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from coma. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, leading sometimes to dramatic improvements. These findings are discussed in the context of current hypotheses of these agents' therapeutic mechanisms on cerebral function. In order to enhance our understanding of the underlying pathophysiological mechanisms of these drugs, we suggest combining sensitive and specific behavioral tools with neuroimaging and electrophysiological measures in large randomized, double-blind, placebo-controlled experimental designs. We conclude that the pharmacokinetics and pharmacodynamics of amantadine, apomorphine and zolpidem need further exploration to determine which treatment would provide a better neurological outcome regarding the patient's etiology, diagnosis, time since injury and overall condition. [less ▲]

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See detailNeuronal and psychological underpinnings of pathological gambling
Singer, Bryan F.; Anselme, Patrick ULg; Robinson, Mike J.F. et al

in Frontiers in Behavioral Neuroscience (2014), 8, 230

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See detailFlexible estimation in cure survival models using Bayesian P-splines
Bremhorst, Vincent; Lambert, Philippe ULg

in Computational Statistics & Data Analysis (2014)

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an ... [more ▼]

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an unknown proportion of the population under study will never experience the monitored event. The promotion time model, which has a biological motivation, is one of the survival models taking this feature into account. The promotion time model assumes that the failure time of each subject is generated by the minimum of N independent latent event times with a common distribution independent of N. An extension which allows the covariates to influence simultane- ously the probability of being cured and the latent distribution is presented. The latent distribution is estimated using a flexible Cox proportional hazard model where the logarithm of the baseline hazard function is specified using Bayesian P-splines. Introducing covariates in the latent distribution implies that the population hazard function might not have a proportional hazard structure. However, the use of P- splines provides a smooth estimation of the population hazard ratio over time. The identification issues of the model are discussed and a restricted use of the model when the follow up of the study is not sufficiently long is proposed. The accuracy of our methodology is evaluated through a simulation study and the model is illustrated on data from a Melanoma clinical trial. [less ▲]

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See detailCompte rendu de James WILBERDING & Christoph HORN (eds.), "Neoplatonism and the Philosophy of Nature"
Gavray, Marc-Antoine ULg

in Revue Philosophique de Louvain (2014), 112(1), 174-176

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See detailL’INTÉRÊT DE LA RADIOTHÉRAPIE «ABLATIVE» EN PRENANT COMME MODÈLE LA MÉTASTASE D’UN CANCER RÉNAL À CELLULES CLAIRES
COUCKE, Philippe ULg; JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 94-100

La radiothérapie en conditions stéréotaxiques, guidée par l’imagerie embarquée, est une alternative valable aux autres modalités de traitement ablatif, en particulier dans le contexte du cancer rénal ... [more ▼]

La radiothérapie en conditions stéréotaxiques, guidée par l’imagerie embarquée, est une alternative valable aux autres modalités de traitement ablatif, en particulier dans le contexte du cancer rénal métastatique (mRCC). L’efficacité du traitement dépend de la dose totale et la dose par fraction et se traduit en Dose Biologique Efficace (BED). Les tech - niques actuelles permettent d’appliquer des doses par frac - tion élevée (> 8 à 10 Gy), ce qui se traduit en effet biologique fondamentalement différent de celui observé dans le contexte d’une radiothérapie conventionnelle, résultant en un taux de réponse local atteignant 80 à 90%. Ce taux de réponse contre - dit le concept historique de tumeur «radiorésistante». L’effet thérapeutique s’explique en partie par un effet anti-angiogé - nique majeur induit par la réponse apoptotique des cellules endothéliales dans la tumeur. Ceci ouvre de nouvelles perspec - tives, en particulier dans le domaine des traitements combi - nant radiothérapie ablative et substances anti-angiogéniques. [less ▲]

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See detailcompte rendu de : Geiger, Joseph. Hellenism in the East: studies on Greek intellectuals in Palestine.
Rochette, Bruno ULg

in Bryn Mawr Classical Review [=BMCR] (2014)

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See detailLateral Magnetic Near-Field Imaging of Plasmonic Nanoantennas With Increasing Complexity
Denkova, D.; Verellen, N.; Silhanek, Alejandro ULg et al

in Small : Nano Micro (2014)

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field ... [more ▼]

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field interactions between their building blocks. While the electric field distributions and, respectively, the electric interactions of different nanostructures can be routinely measured, for example, by scattering near-field microscopy, only recently experimental methods for imaging the magnetic field distributions became available. In this paper, we provide direct experimental maps of the lateral magnetic near-field distributions of variously shaped plasmonic nanoantennas by using hollow-pyramid aperture scanning near-field optical microscopy (SNOM). We study both simple plasmonic nanoresonators, such as bars, disks, rings and more complex antennas. For the studied structures, the magnetic near-field distributions of the complex resonators have been found to be a superposition of the magnetic near-fields of the individual constituting elements. These experimental results, explained and validated by numerical simulations, open new possibilities for engineering and characterization of complex plasmonic antennas with increased functionality. [less ▲]

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See detailLakeMIP Kivu: evaluating the representation of a large, deep tropical lake by a set of one-dimensional lake models
Thiery, Wim; Stepanenko, Victor M.; Fang, Xing et al

in Tellus : Series A (2014), 66

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See detailPharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2014)

Introduction: Patients with type 2 diabetes have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis and about one-third of cirrhotic patients ... [more ▼]

Introduction: Patients with type 2 diabetes have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis and about one-third of cirrhotic patients have diabetes. However, the use of several antidiabetic agents may be a cause for concern in the case of hepatic impairment (HI). Areas covered: An extensive literature search was performed to analyze the influence of HI on the pharmacokinetics (PK) of glucose-lowering agents and the potential consequences for clinical practice as far as the efficacy/safety balance of their use in diabetic patients with CLD is concerned. Expert opinion: Almost no PK studies have been published regarding metformin, sulfonylureas, thiazolidinediones and alpha-glucosidase inhibitors in patients with HI. Only mild changes in PK of glinides, dipeptidyl peptidase-4 inhibitors and sodium glucose cotransporters type 2 inhibitors were observed in dedicated PK studies in patients with various degrees of HI, presumably without major clinical relevance although large clinical experience is lacking. Glucagon-like peptide-1 receptor agonists have a renal excretion rather than liver metabolism. Rare anecdotal case reports of hepatotoxicity have been described with various glucose-lowering agents contrasting with numerous reassuring data. Nevertheless, caution should be recommended, especially in patients with advanced cirrhosis, including with the use of metformin. [less ▲]

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See detailSolid–fluid transition modelling in geomaterials and application to a mudflow interacting with an obstacle
Prime, Noémie ULg; Dufour, Frédéric; Darve, Félix

in International Journal for Numerical and Analytical Methods in Geomechanics (2014)

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See detailPeripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly.
SOMJA, Joan ULg; Bisig, B.; de Leval, L. et al

in Virchows Archiv : An International Journal of Pathology (2014)

Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14 ... [more ▼]

Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14)(p25;q11) and FISH-proved breakpoints in the IRF4 and TCRAD loci, leading to juxtaposition of both genes. A 64-year-old male patient presented with mild cytopenias and massive splenomegaly. Splenectomy showed diffuse red pulp involvement by a pleomorphic medium- to large-cell T-cell lymphoma with a CD2+ CD3+ CD5− CD7− CD4+ CD8+/− CD30− TCRbeta-F1+ immunophenotype, an activated cytotoxic profile, and strong MUM1 expression. The clinical course was marked by disease progression in the bone marrow under treatment and death at 4 months. In contrast with two t(6;14)(p25;q11.2)-positive lymphomas previously reported to be cytotoxic PTCL, NOS with bone marrow and skin involvement, this case was manifested by massive splenomegaly, expanding the clinical spectrum of PTCLs harboring t(6;14)(p25;q11.2) and supporting consideration of this translocation as a marker of biological aggressiveness. [less ▲]

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See detailLA RADIOBIOLOGIE POUR LES NÉOPHYTES
COUCKE, Philippe ULg; MARTINIVE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 16-19

La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec ... [more ▼]

La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec l’épargne des tissus sains avoisinants, rend possible une nouvelle exploitation de concept de radio - biologie. L’exemple type est la redécouverte des traitements hypo-fractionnés. [less ▲]

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See detailImpact of anisotropy and viscosity to model the mechanical behavior of Ti-6Al-4V alloy
Tuninetti Vásquez, Victor ULg; Habraken, Anne ULg

in Materials Science and Engineering: A (2014)

This paper compares the predictions of an isotropic-thermo-elasto-viscoplastic approach and of an anisotropic-thermo-elastoplastic one with experimental results representative of the mechanical behavior ... [more ▼]

This paper compares the predictions of an isotropic-thermo-elasto-viscoplastic approach and of an anisotropic-thermo-elastoplastic one with experimental results representative of the mechanical behavior of Ti-6Al-4V at moderate temperatures and low strain rates. The first model is the well known Norton-Hoff viscoplastic constitutive law with isotropic von Mises yield locus identified by using monotonic tension tests performed at strain rates from 10-3 s-1 to 10-1 s-1 and at temperatures up to 400°C. The second model is a thermo-elasto-plastic one defined by the orthotropic yield criterion CPB06. It takes into account the anisotropy and the strength differential (SD) effect in tension-compression of Ti-6Al-4V at RT, 150°C and 400°C. The identification of the SD effect is done by using tension and compression tests and the anisotropy behavior is identified by using shear, plane strain, tension and compression tests performed in three orthogonal material directions. The accuracy of the load and displacements predictions of the two macroscopic constitutive models are compared to experimental results obtained from tests performed on specimens with multiaxial loadings and large strain at several temperatures. [less ▲]

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See detailPhysiological and proteomic responses of different willow clones (Salix fragilis x alba) exposed to dredged sediment contaminated by heavy metals
Evlard, Aricia ULg; Sergeant, Kjell; Ferrandis, Salvador et al

in International Journal of Phytoremediation (2014), 16(11), 1148-1169

High biomass producing species are considered as tools for remediation of contaminated soils. Willows (Salix spp.) are prominent study subjects in this regard. In this study, different willow clones ... [more ▼]

High biomass producing species are considered as tools for remediation of contaminated soils. Willows (Salix spp.) are prominent study subjects in this regard. In this study, different willow clones (Salix fragilis x alba) were planted on heavy-metal polluted dredging sludge. A first objective was assessment of the biomass production for these clones. Using a Gupta statistic, four clones were identified as high biomass producers (HBP). For comparison, a group of four clones with lowest biomass production were selected (LBP). A second objective was to compare metal uptake as well as the physiological and proteomic responses of these two groups. All these complementary data's allow us to have a better picture of the health of the clones that would be used in phytoremediation programs. Cd, Zn, and Ni total uptake was higher in the HBPs but Pb total uptake was higher in LBPs. Our proteomic and physiological results showed that the LBPs were able to maintain cellular activity as much as the HBPs although the oxidative stress response was more pronounced in the LBPs. This could be due to the high Pb content found in this group although a combined effect of the other metals cannot be excluded. [less ▲]

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See detailAn effective finite-element-based method for the computation of nonlinear normal modes of nonconservative systems
Renson, Ludovic ULg; Deliège, Geoffrey ULg; Kerschen, Gaëtan ULg

in Meccanica (2014), 49(8), 1901-1916

This paper addresses the numerical computation of nonlinear normal modes defined as two-dimensional invariant manifolds in phase space. A novel finite-element-based algorithm, combining the streamline ... [more ▼]

This paper addresses the numerical computation of nonlinear normal modes defined as two-dimensional invariant manifolds in phase space. A novel finite-element-based algorithm, combining the streamline upwind Petrov-Galerkin method with mesh moving and domain prediction-correction techniques, is proposed to solve the manifold-governing partial differential equations. It is first validated using conservative examples through the comparison with a reference solution given by numerical continuation. The algorithm is then demonstrated on nonconservative examples. [less ▲]

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See detailLe rôle de l’entourage au sein de l’hôpital africain : une thématique négligée ?
Schnitzler, Marie ULg

in Sciences Sociales et Santé (2014), 32(1), 39-64

En mobilisant le cadre théorique interactionniste pensé par Strauss (1992), cet article décrit les différentes tâches effectuées par l’entourage du malade dans un hôpital béninois afin de montrer comment ... [more ▼]

En mobilisant le cadre théorique interactionniste pensé par Strauss (1992), cet article décrit les différentes tâches effectuées par l’entourage du malade dans un hôpital béninois afin de montrer comment ce travail réalisé gratuitement par des travailleurs profanes favorise le fonctionnement au jour le jour de la structure. Les concepts d’« intermédiation » et de « dépendance » permettent de saisir les contraintes familiales exercées sur le patient en plus du contrôle médical. En conclusion, cet article prône le développement d’études sur les garde-malades pour renouveler les recherches sur la relation thérapeutique et sur l’organisation hospitalière en Afrique de l’Ouest. [less ▲]

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See detailPure and Pseudo-pure Fluid Thermophysical Property Evaluation and the Open-Source Thermophysical Property Library CoolProp
Bell, Ian ULg; Wronski, Jorrit; Quoilin, Sylvain ULg et al

in Industrial & Engineering Chemistry Research (2014), 53

Article Pure and Pseudo-pure Fluid Thermophysical Property Evaluation and the Open-Source Thermophysical Property Library CoolProp ACS ActiveView PDFHi-Res Print, Annotate, Reference QuickView PDF [2027 ... [more ▼]

Article Pure and Pseudo-pure Fluid Thermophysical Property Evaluation and the Open-Source Thermophysical Property Library CoolProp ACS ActiveView PDFHi-Res Print, Annotate, Reference QuickView PDF [2027 KB] PDF w/ Links[457 KB] Full Text HTML Abstract Supporting Info -> Figures Reference QuickView Add to ACS ChemWorx Ian H. Bell *†, Jorrit Wronski *‡, Sylvain Quoilin *†, and Vincent Lemort *† † Energy Systems Research Unit, University of Liège, Liège, Belgium ‡ Department of Mechanical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark Ind. Eng. Chem. Res., 2014, 53 (6), pp 2498–2508 DOI: 10.1021/ie4033999 Publication Date (Web): January 13, 2014 Copyright © 2014 American Chemical Society OpenURL UNIV DE LIEGE *E-mail: ian.bell@ulg.ac.be., *E-mail: jowr@mek.dtu.dk., *E-mail: squoilin@ulg.ac.be., *E-mail: vincent.lemort@ulg.ac.be. ACS AuthorChoice Abstract Over the last few decades, researchers have developed a number of empirical and theoretical models for the correlation and prediction of the thermophysical properties of pure fluids and mixtures treated as pseudo-pure fluids. In this paper, a survey of all the state-of-the-art formulations of thermophysical properties is presented. The most-accurate thermodynamic properties are obtained from multiparameter Helmholtz-energy-explicit-type formulations. For the transport properties, a wider range of methods has been employed, including the extended corresponding states method. All of the thermophysical property correlations described here have been implemented into CoolProp, an open-source thermophysical property library. This library is written in C++, with wrappers available for the majority of programming languages and platforms of technical interest. As of publication, 110 pure and pseudo-pure fluids are included in the library, as well as properties of 40 incompressible fluids and humid air. The source code for the CoolProp library is included as an electronic annex. [less ▲]

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See detailChemical and biological evaluation of the nutritive value of Algerian green seaweed Ulva lactuca using in vitro gas production technique fior ruminant animals
Zitouni, Hind; Arhab, Rabah; Boudry, Christelle ULg et al

in International Journal of Advanced Research (2014), 2(4), 916-925

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to ... [more ▼]

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to vetch-oat hay (control), using in vitro gas production technique. Seaweed and control were incubated with rumen liquor taken from fistulated and non lactating cows. Gas production was recorded at: 2, 4, 6, 8, 12, 24, 48 and 72h. The in vitro rumen fermentation parameters were measured after 24h and 72h of fermentation. Proteins degradability was investigated by the enzymatic technique using a protease extracted from Streptomyces griseus. The results showed a wide variation between the chemical components of seaweed and conventional fodder used as control. The main constituents in Ulva lactuca were ashes (39.1% DM), fibers (22.8 % DM) and proteins (15.3% DM). The gas production profile of seaweed during 72h of incubation showed a slow and low gas production. Cumulative gas production obtained after 24h for seaweed (42 ml/g OM) was significantly lower than control (128.4 ml/g OM) (P<0.001). pH, ammonia, volatile fatty acids (VFAs), apparent digestibility of dry matter (DDM), organic matter digestibility (OMD) and metabolizable energy (ME) were significantly different between seaweed and vetch-oat hay (6.86, 290.1 mg/ml, 1.25 mmol/g DM, 38.3%, 29.2%, 3.81MJ/Kg DM respectively for seaweed). Protein degradability measurement indicates the weak hydrolysis of seaweed crude protein which is beneficial for ruminants. This study showed that the use of Ulva lactuca as non conventional feed in ruminant nutrition can be considered under certain conditions. [less ▲]

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See detailComparison of a Fluid and a Solid Approach for the Numerical Simulation of Friction Stir Welding with a Non‐Cylindrical Pin
Bussetta, Philippe ULg; Dialami, Narges; Boman, Romain ULg et al

in Steel Research International (2014), 85(6), 968-979

Friction stir welding (FSW) process is a solid‐state joining process during which materials to be joined are not melted. As a consequence, the heat‐affected zone is smaller and the quality of the weld is ... [more ▼]

Friction stir welding (FSW) process is a solid‐state joining process during which materials to be joined are not melted. As a consequence, the heat‐affected zone is smaller and the quality of the weld is better with respect to more classical welding processes. Because of extremely high strains in the neighborhood of the tool, classical numerical simulation techniques have to be extended in order to track the correct material deformations. The Arbitrary Lagrangian–Eulerian (ALE) formulation is used to preserve a good mesh quality throughout the computation. With this formulation, the mesh displacement is independent from the material displacement. Moreover, some advanced numerical techniques such as remeshing or a special computation of transition interface is needed to take into account non‐cylindrical tools. During the FSW process, the behavior of the material in the neighborhood of the tool is at the interface between solid mechanics and fluid mechanics. Consequently, a numerical model of the FSW process based on a solid formulation is compared to another one based on a fluid formulation. It is shown that these two formulations essentially deliver the same results in terms of pressures and temperatures. [less ▲]

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See detailLa primauté de l'intentionnalité et ses conséquences épistémologiques
Boccaccini, Federico ULg

in Bulletin d'Analyse Phénoménologique (2014)

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See detailKluge, Adorno et l’indomptable Leni Peickert
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Cahiers du GRM (2014), 5

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See detailEuropean multicentre validation study of the accuracy of E/e' ratio in estimating invasive left ventricular filling pressure: EURO-FILLING study.
Galderisi, Maurizio; Lancellotti, Patrizio ULg; Donal, Erwan et al

in European Heart Journal - Cardiovascular Imaging (2014)

AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for ... [more ▼]

AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for calculating the ratio between the preload-dependent transmitral E velocity and the average of septal and lateral early diastolic velocities (e') of the mitral annulus. Despite its wide use, real utility of the E/e' ratio has been recently challenged in patients with either very advanced heart failure or preserved left ventricular (LV) ejection fraction. However, only few studies performed the invasive and non-invasive estimation of LVFP simultaneously. The EURO-FILLING Study will validate the E/e' ratio (and additional non-invasive estimates) against simultaneously measured LVFP obtained by left heart catheterization in a multicentre study involving reference European echo laboratories collecting a wide population sample size of cardiac patients with and without heart failure. METHODS AND RESULTS: The EURO-FILLING study is a large, prospective observational study in which simultaneous assessment of invasive and non-invasive measurements of LVFP will be acquired in eight reference European centres. Centralized reading of the collected parameters will be performed in a core laboratory. Not only standardized echo Doppler measurements but also novel echo parameters such as LV global longitudinal strain and global atrial strain (obtainable by two-dimensional speckle tracking echocardiography) will be tested for predicting invasive measurements of LVFP. CONCLUSIONS: The EURO-FILLING study is expected to provide important information on non-invasive assessment of LVFP and to contribute to the standardization of this assessment in clinical practice. [less ▲]

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See detailUse of sapropterin dihydrochloride in maternal phenylketonuria. A European experience of eight cases.
Feillet, Francois; Muntau, Ania C.; DEBRAY, François-Guillaume ULg et al

in Journal of inherited metabolic disease (2014)

Sapropterin dihydrochloride (SD) is the first drug treatment for phenylketonuria (PKU), but due to the lack of data, its use in maternal PKU must be undertaken with caution as noted in the FDA and EMEA ... [more ▼]

Sapropterin dihydrochloride (SD) is the first drug treatment for phenylketonuria (PKU), but due to the lack of data, its use in maternal PKU must be undertaken with caution as noted in the FDA and EMEA labels. We collected data from eight pregnancies in PKU women treated with SD and we analysed the phenotypes of these patients, their tetrahydrobiopterin (BH4) responsiveness, the indications for SD treatment, the efficacy (metabolic control, phenylalanine (Phe) tolerance and offspring outcome) and the safety data. Results showed that in the seven patients known to be responsive to BH4, the use of SD during pregnancy was efficient in terms of metabolic control and Phe tolerance. The indications for giving SD included the failure of the low-Phe diet (n = 3), the fact that some of these women had never experienced the low Phe diet (n = 2), one unexpected pregnancy in a woman currently on SD and one pregnancy where the foetus was known to have PKU. The offspring of these seven pregnancies were all normal babies with normal birth measurements and outcomes. No side effect related to SD was observed in these seven cases. In the eighth case, SD was prescribed as a rescue treatment without previous knowledge of the BH4 responsiveness to a woman who was already 8 weeks pregnant without diet. The birth occurred at 33 weeks of gestational age with Potter syndrome (probably related to the absence of metabolic control during the first trimester) and the baby died in the first hours of life. In conclusion, the data presented here provides the first evidence that treatment with pharmacological doses of SD appears to be efficient and safe in women with PKU during pregnancy. Its use should, however, be restricted to those women previously identified to be clear responders to BH4. [less ▲]

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See detailClinical variability in neurohepatic syndrome due to combined mitochondrial DNA depletion and Gaucher disease
HARVENGT, Julie ULg; wanty, catherine; De Paepe, Boel et al

in Molecular Genetics and Metabolism Reports (2014)

A one year old girl born to consanguineous parents presented with unexplained liver failure, leading to transplantation at 19 months. Subsequent partial splenectomy for persistent cytopenia showed the ... [more ▼]

A one year old girl born to consanguineous parents presented with unexplained liver failure, leading to transplantation at 19 months. Subsequent partial splenectomy for persistent cytopenia showed the presence of foamy cells, and Gaucher disease was confirmed by homozygosity for the p.Leu483Pro mutation in the GBA gene. She was treated by enzyme replacement therapy (ERT). Clinical follow-up showed mild developmental delay, strabism, nystagmus and oculomotor apraxia. Biochemical studies revealed multiple respiratory chain deficiencies and a mosaic pattern of deficient complex IV immunostaining in liver and fibroblast. Molecular analysis identified a mtDNA depletion syndrome due to the homozygous p.Pro98Leu mutation in MPV17. A younger sister unaffected by mtDNA depletion, presented with pancytopenia and hepatosplenomegaly. ERT for Gaucher disease resulted in visceral normalization, without any neurological symptom. A third sister, affected by both conditions, had marked developmental delay, strabism and ophthalmoplegia but no liver cirrhosis. In conclusion, intrafamilal variability occurs in MPV17 related disease. The combined pathological effect of Gaucher and mitochondrial diseases can negatively impact neurological and liver functions, and influence the outcome in consanguineous families. Immunocytochemical staining of OXPHOS protein in tissues and cultured cells is a powerful tool revealing mosaic pattern of deficiency pointing to mtDNA related mitochondrial disorders. [less ▲]

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See detailPlant Water Uptake in Drying Soils
Lobet, Guillaume ULg; Couvreur, Valentin; Meunier, Félicien et al

in Plant Physiology (2014), in press

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See detailCriteria and tools for objectively analysing the vocal accuracy of a popular song
Larrouy, Pauline ULg; Morsomme, Dominique ULg

in Logopedics, Phoniatrics, Vocology (2014), 39

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt ... [more ▼]

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt and OpenMusic (Ircam, Paris, France). In terms of evaluation of the pitch interval deviation, we replicated the profile of occasional singers described in the literature (the slower the performance, the more accurate it is). Our results also confirm that the professional singers sing more accurately than occasional singers but not when a Western operatic singing technique is involved. These results support the relevance of our method for analysing vocal accuracy of occasional and professional singers and led us to discuss adaptations to be implemented for analysing the accuracy of operatic voices. [less ▲]

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See detailOrganization of microbeads in Leidenfrost droplet
Maquet, Laurent ULg; Colinet, Pierre; Dorbolo, Stéphane ULg

in Soft Matter (2014), 10

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See detailCrystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli
Sauvage, Eric; Derouaux, Adeline ULg; Fraipont, Claudine ULg et al

in PLoS ONE (2014)

In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell division. PBP3 is ... [more ▼]

In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell division. PBP3 is mainly periplasmic, with a 23 residues cytoplasmic tail and a single transmembrane helix. We have solved the crystal structure of a soluble form of PBP3 (PBP357-577) at 2.5 Å revealing the two modules of high molecular weight class B PBPs, a carboxy terminal module exhibiting transpeptidase activity and an amino terminal module with unknown function. To gain additional insight, the PBP3 Val88-Ser165 subdomain (PBP388-165), for which the electron density is poorly defined in the PBP3 crystal, was produced and its structure solved by SAD phasing at 2.1 Å. The structure shows a three dimensional domain swapping with a β-strand of one molecule inserted between two strands of the paired molecule, suggesting a possible role in PBP357-577 dimerization. [less ▲]

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See detailSurgical treatment of bicuspid aortic valve disease: Knowledge gaps and research perspectives.
Della Corte, Alessandro; Body, Simon C.; Booher, Anna M. et al

in The Journal of thoracic and cardiovascular surgery (2014)

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See detailRessources naturelles, matières premières et géographie. L'exemple des ressources énergétiques et minières
Deshaies, Michel; Merenne-Schoumaker, Bernadette ULg

in BSGLg (2014), 62

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has ... [more ▼]

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has evolved over time and then analyze new research issues that emerge from a decade. Through this brief analysis, everything indicates a real expansion of fields of investigation, undoubtedly related to the new challenges and opportunities posed by resources that go far beyond the traditional field of economic geography. [less ▲]

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See detailSECOND ORDER SYMMETRIES OF THE CONFORMAL LAPLACIAN
Michel, Jean-Philippe ULg; Radoux, Fabian ULg; Silhan, Josef

in Symmetry, Integrability and Geometry: Methods and Applications [=SIGMA] (2014), 10(016), 26

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by ... [more ▼]

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by differential operators of second order. They are constructed from conformal Killing 2-tensors satisfying a natural and conformally invariant condition. As a consequence, we get also the classification of the second order symmetries of the conformal Laplacian. Our results generalize the ones of Eastwood and Carter, which hold on conformally flat and Einstein manifolds respectively. We illustrate our results on two families of examples in dimension three. [less ▲]

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See detailInfluence du changement climatique sur l'accroissement du hêtre en Wallonie
Latte, Nicolas ULg; Claessens, Hugues ULg

in Forêt Wallonne (2014), (129), 46-47

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See detailBone forming agents for the management of osteoporosis
Reginster, Jean-Yves ULg; Neuprez, A.; Beaudart, Charlotte ULg et al

in Panminerva medica (2014), 56(2), 97-114

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these ... [more ▼]

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these medications provide only limited fracture reduction and may be linked to skeletal and non-skeletal long-term safety concerns. Therefore, some patients are considered candidates for bone-forming agents because they remain severely osteoporotic or because they failed antiresorptive therapy. Over the last decade, a particular interest was shown in the developmentofmedicationsabletoincreaseosteoblastsnumber,lifespan or activity, hence stimulating bone formation Peptides from the parathyroid hormone family and strontium ranelate were shown to significantly reduce fracture rates but strontium ranelate is no longer an option for treating osteoporosis because of its safety profile. New therapeutic options, including monoclonal antibodies against sclerostin seem to be promising but their role in the armamentarium of osteoporosis will depend on the results of the current phase 3 studies, assessing antifracture efficacy and long-term safety. [less ▲]

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See detailInteraction of fengycin with stratum corneum mimicking model membranes: a calorimetry study
Eeman, Marc; Oloffson, Gerd; Sparr, Emma et al

in Colloids and Surfaces B : Biointerfaces (2014), In Press

Based on its outstanding antifungal properties, it is reasonable to believe that fengycin might be efficient to topically treat localized dermatomycoses. Since most of the fungi species involved in the ... [more ▼]

Based on its outstanding antifungal properties, it is reasonable to believe that fengycin might be efficient to topically treat localized dermatomycoses. Since most of the fungi species involved in the formation of those mycotic skin diseases colonize primarily the stratum corneum (SC), studying the interaction between fengycin and SC-mimicking lipid membranes is a primary step to determine the potential of fengycin to overcome the physical barrier of the skin. In this respect, multilamellar lipid vesicles (MLVs), with a lipid composition mimicking that of the SC, were prepared and characterized by differential scanning calorimetry (DSC). The critical micelle concentration (CMC) of fengycin was also assessed under skin conditions and found to be 1.2 ± 0.1 μM. The molecular interactions of fengycin with SC-mimicking MLVs were investigated by both DSC and isothermal titration calorimetry (ITC). Results showed that the interactions were considerably affected by changes in lipid phase behaviour. At 40 °C and below, fengycin induced exothermic changes in the lipid structures suggesting that less-ordered lipid domains became more-ordered in presence of fengycin. At 60 °C, clearly endothermic interaction enthalpies were observed, which could arise from the “melting” of remaining solid domains enriched in high melting lipids that without fengycin melt at higher temperatures. [less ▲]

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See detailCompte rendu : Michel FRANCARD, Wallon, picard, gaumais, champenois. Les langues régionales de Wallonie
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2014)

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See detailIndirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women.
Ellis, Alexandra G.; Reginster, Jean-Yves ULg; Luo, Xuemei et al

in Current medical research and opinion (2014), 30(8), 1617-1626

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on ... [more ▼]

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on evidence from randomized controlled trials (RCTs). Methods: Eight RCTs assessing vertebral fracture risk reduction with oral bisphosphonates (n = 7) or bazedoxifene (n = 1) were identified by a systematic literature review. Individual study results were pooled in a network meta-analysis (NMA) to indirectly compare treatment effects for overall PMO women and a higher-risk subgroup (FRAX >/= 20%). Three sets of NMA analyses were conducted: aggregate data (AD) from the bisphosphonate RCTs and bazedoxifene RCT for the full population or the FRAX >/=20% subgroup (NMA AD); bisphosphonate AD and bazedoxifene AD from each FRAX subgroup adjusted for baseline risk (NMA AD meta-regression); and bisphosphonate AD and bazedoxifene individual patient data (IPD) adjusted for baseline risk/FRAX (NMA AD/IPD meta-regression). Results: For the overall population, bisphosphonates had lower fracture risks versus bazedoxifene although there is considerable uncertainty in supporting one intervention over another. The relative risk reduction (RRR) for bazedoxifene was -0.23 (95% CrI: -1.11, 0.27) versus ibandronate, -0.17 (-0.76, 0.22) versus alendronate, and -0.06 (-0.62, 0.30) versus risedronate. Results from the meta-regression analyses were similar. For the FRAX >/=20% population, estimated fracture rates with bazedoxifene were lower than with bisphosphonates, but again the uncertainty limits strong interpretation. The RRR for bazedoxifene was 0.51 (-0.31, 0.83) versus ibandronate, 0.53 (-0.18, 0.83) versus alendronate, and 0.57 (-0.07, 0.85) versus risedronate. The meta-regression analyses showed comparable findings. Conclusion: The analyses only considered vertebral fractures for oral bisphosphonates versus bazedoxifene, and IPD was available only for bazedoxifene. In light of this, bazedoxifene is comparable to bisphosphonates in the overall PMO population and at least as effective as bisphosphonates for preventing vertebral fractures among higher-risk PMO patients. The findings suggest bazedoxifene performs better in higher-risk PMO than in the overall PMO. [less ▲]

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See detailIs dolphin morbillivirus virulent for white-beaked dolphins (Lagenorhynchus albirostris)?
van Elk, N.; van de Bildt, M.; Jauniaux, Thierry ULg et al

in Veterinary Pathology (2014)

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See detailResponse to Dr Bolland's eLetter: Strontium and cardiovascular events.
REGINSTER, Jean-Yves ULg

in Annals of the rheumatic diseases (2014), 73(2), 9

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See detailA French Translation of the Childhood Anxiety Sensitivity Index (CASI): Factor Structure, Reliability and Validity of This Scale in a Nonclinical Sample of Children
Stassart, Céline ULg; Etienne, Anne-Marie ULg

in Psychologica Belgica (2014)

Introduction: Anxiety sensitivity (AS) refers to the fear of anxiety-related sensations due to beliefs that these sensations will lead to catastrophic outcomes. AS plays a central role in the etiology and ... [more ▼]

Introduction: Anxiety sensitivity (AS) refers to the fear of anxiety-related sensations due to beliefs that these sensations will lead to catastrophic outcomes. AS plays a central role in the etiology and maintenance of anxiety disorders. From a clinical perspective, it therefore seems important to possess a valid scale to assess AS in children. Objective, Method: This study examines the factor structure, reliability, and validity of the French translation of the Childhood Anxiety Sensitivity Index (CASI) in 353 Belgian children (9 to 13 years). Result: Results show that AS can be adequately measured using the French version of the CASI and conceptualized as a hierarchical factor structure with four lower-order factors – Physical Concerns, Mental Incapacity Concerns, Social Concerns, and Losing Control Concerns – loading on a single higher-order factor, Anxiety Sensitivity. The reliability was acceptable for the total scale. Hierarchical multiple regressions show that the CASI makes a significant contribution in predicting anxiety. conclusion: The data support the relevance of the French CASI in the assessment of AS in nonclinical children. [less ▲]

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See detailEffects of melody and technique on acoustical and musical features of Western operatic singing voices
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Journal of Voice (2014)

Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains ... [more ▼]

Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains unclear. This study aims to further characterize the Western operatic singing technique by observing the effects of melody and technique on acoustical and musical parameters of the singing voice. Methods: Fifty professional singers performed two contrasting melodies (popular song and romantic melody) with two vocal techniques (with and without operatic singing technique). The common quality parameters (energy distribution, vibrato rate and extent), perturbation parameters (standard deviation of the fundamental frequency, signal-to-noise ratio, jitter and shimmer) and musical features (fundamental frequency of the starting note, average tempo, and sound pressure level) of the 200 sung performances were analyzed. Results: The results regarding the effect of melody and technique on the acoustical and musical parameters show that the choice of melody had a limited impact on the parameters observed, whereas a particular vocal profile appeared depending on the vocal technique employed. Conclusions: This study confirms that vocal technique affects most of the parameters examined. In addition, the observation of quality, perturbation and musical parameters contributes to a better understanding of the Western operatic singing technique. [less ▲]

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See detailUnique recurrence patterns of cervical intraepithelial neoplasia following excision of the squamo-columnar junction.
Herfs, Michael ULg; SOMJA, Joan ULg; Howitt, Brooke E. et al

in International journal of cancer. Journal international du cancer (2014)

Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamo-columnar junction (SCJ) and suggest that these cells may not ... [more ▼]

Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamo-columnar junction (SCJ) and suggest that these cells may not regenerate following excision (LEEP). This study addressed the impact of SCJ excision on the temporal dynamics, histologic and viral (HPV) characteristics of recurrent CIN. One hundred thirty one consecutive patients treated by excision and attending follow-up visits were enrolled. We compared recurrent and initial CIN with attention to excision margins, timing of recurrence, CIN grade, HPV types, p16 immunophenotype, and SCJ immunophenotype. During the follow-up period (up to four years), sixteen (12.2%) recurrences were identified. Four (25%) were identified at the first follow-up visit, closely resembled the initial CIN 2/3 in grade and HPV type, and were typically SCJ marker positive [SCJ(+)], suggesting non-excised (residual) disease. Twelve (75%) manifested after the first postoperative visit and all were in the ectocervix or in mature metaplastic epithelium. All of the 12 delayed recurrences were classified as CIN 1 and were SCJ (-). Nine of 11 SCJ (-) recurrences (82%) followed regressed spontaneously. Taken together, these results show that new lesions developing from any HPV infection are delayed and occur within the ectocervix or metaplastic epithelium. This dramatically lower risk of CIN 2/3 following successful SCJ excision suggests that removal of the SCJ could be a critical variable in reducing the risk of subsequent CIN 2/3 and cervical cancer. (c) 2014 Wiley Periodicals, Inc. [less ▲]

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See detailMultiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations
Demertzi, Athina ULg; Gomez, Francisco; Crone, Julia-Sophia et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 52

Introduction: In healthy conditions, group-level fMRI resting state analyses identify ten resting state networks (RSNs) of cognitive relevance. Here, we aim to assess the tennetwork model in severely ... [more ▼]

Introduction: In healthy conditions, group-level fMRI resting state analyses identify ten resting state networks (RSNs) of cognitive relevance. Here, we aim to assess the tennetwork model in severely brain-injured patients suffering from disorders of consciousness and to identify those networks which will be most relevant to discriminate between patients and healthy subjects. Methods: 300 fMRI volumes were obtained in 27 healthy controls and 53 patients in minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/ UWS) and coma. Independent component analysis (ICA) reduced data dimensionality. The ten networks were identified by means of a multiple template-matching procedure and were tested on neuronality properties (neuronal vs non-neuronal) in a data-driven way. Univariate analyses detected between-group differences in networks’ neuronal properties and estimated voxel-wise functional connectivity in the networks, which were significantly less identifiable in patients. A nearest-neighbor “clinical” classifier was used to determine the networks with high between-group discriminative accuracy. Results: Healthy controls were characterized by more neuronal components compared to patients in VS/UWS and in coma. Compared to healthy controls, fewer patients in MCS and VS/UWS showed components of neuronal origin for the left executive control network, default mode network (DMN), auditory, and right executive control network. The “clinical” classifier indicated the DMN and auditory network with the highest accuracy (85.3%) in discriminating patients from healthy subjects. [less ▲]

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See detailWhat is Africa to me now?
Ledent, Bénédicte ULg; Tunca, Daria ULg

in Transition (2014), 113

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See detailElaboration of Thin Foils in Copper and Zinc by Self-Induced Ion Plating
Giraud, Eliane; Pace, Sergio ULg; Lecomte-Beckers, Jacqueline ULg

in Materials Science (2014), 20(2), 160-164

The aim of this work was to determine the ability to produce thin metallic foils by self-induced ion plating. Foils of pure copper and pure zinc with a thickness of 35 μm have been successfully produced ... [more ▼]

The aim of this work was to determine the ability to produce thin metallic foils by self-induced ion plating. Foils of pure copper and pure zinc with a thickness of 35 μm have been successfully produced and their characteristics have been compared to foils obtained by conventional techniques (i. e. electroplating and rolling). Results show the following: (i) more or less compact microstructures can be obtained by self-induced ion plating depending on gas pressure and substrate temperature; (ii) microstructures obtained by self-induced ion plating are quite different from those obtained by electroplating and rolling; (iii) Young’s modulus depends on foils roughness; (iv) hardness depends on grain size by exhibiting a Hall-Petch behavior in the case of copper foils and an “inverse” Hall-Petch behavior in the case of zinc foils. [less ▲]

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See detailPostures d’apprenants et images sociotypées du professeur de français langue étrangère dans le contexte de la mobilité Erasmus
Meunier, Deborah ULg

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2014), 49.1

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See detailBook Review: Handbook of research methods on social entrepreneurship
Dufays, Frédéric ULg

in International Small Business Journal (2014), 32(4), 471-475

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See detailRole of larval host plant experience and solanaceous plant volatile emissions in Tuta absoluta (Lepidoptera: Gelechiidae) host finding behavior
Caparros Megido, Rudy ULg; De Backer, Lara; Ettaïb, Refki et al

in Arthropod-Plant Interactions (2014)

The tomato leafminer, Tuta absoluta (Lepi- doptera: Gelechiidae), is considered to be a major pest that damages tomato (Solanum lycopersicum L; Solanaceae) crops in South American, European, and ... [more ▼]

The tomato leafminer, Tuta absoluta (Lepi- doptera: Gelechiidae), is considered to be a major pest that damages tomato (Solanum lycopersicum L; Solanaceae) crops in South American, European, and Mediterranean countries. This insect species is polyphagous (i.e., feeds on many types of food); hence, it could also develop on other cultivated host plants, principally solanaceous plants, such as potato (S. tuberosum L.; Solanaceae) and eggplant (S. melongena L.; Solanaceae). Therefore, we tested the hypothesis that host plant choice by adult T. absoluta is influenced by plant volatile organic compounds and larval host plant experience. One tomato cultivar (cv.) ‘Money- maker’ and three potato cv. ‘Charlotte’ ‘Bintje,’ and ‘Nicola’ were tested. Using a flying tunnel, we observed that females reared on tomato preferred flying toward tomato and, to a lesser extent, potato cv. ‘Charlotte.’ These preferences might be explained by the high release of terpenes by these two plants. When conducting oviposition choice assays, we found no preference between tomato and potato in the number of eggs laid by females that had been previously reared on either host plant. This study indicates that the host finding behavior of T. absoluta is mediated by solanaceous volatiles, while oviposition behavior appears to depend on additional stimuli. These results provide baseline information for use in the development of new control strategies against T. absoluta using semiochemicals and plant breeding. [less ▲]

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See detailCompte rendu de Han BALTUSSEN, Michael ATKINSON, Michael SHARE, Ian MUELLER (trad.), Simplicius: On Aristotle Physics 1.5-9
Gavray, Marc-Antoine ULg

in International Journal of the Platonic Tradition (2014), 8(1), 115-117

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See detailConstitutional Aspects of FTAs: a Colombian Perspective
Parra Santamaria, Lusmiriam Andrea ULg; De Lombaerde, Philippe; Lizarazo, Liliana et al

in European Journal of Law (2014)

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See detailEditorial
Bourgeois, Marc ULg

in Revue de Fiscalité Régionale et Locale (2014), Liv. 1

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See detailAtlantic-Pacific seesaw and its role in outgassing CO2 during Heinrich events
Menviel, L.; England, M.H.; Meissner, K.J. et al

in Paleoceanography (2014), 29

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See detailRevisiting the Palaeolithic site of Kulbulak (Uzbekistan): First results from luminescence dating
Vandenberghe, D.A.G.; Flas, Damien ULg; De Dapper, Morgan et al

in Quaternary International (2014), 324

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See detailIntroduction to Mapping Diasporic Subjectivities
Munos, Delphine ULg; Pandurang, Mala

in South Asian Diaspora (2014), 6(1), 1-5

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See detailReview: Yves Gingras, Sociologie des sciences, Paris, PUF, 2013, pp.128
Vangeebergen, Thomas ULg

in Tecnoscienza (2014), 5(1),

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See detailMicrobial heterogeneity affects bioprocess robustness: Dynamic single cell analysis contribute to understanding microbial populations
Delvigne, Frank ULg; Goffin, Philippe

in Biotechnology Journal (2014), 9(1), 61-72

Heterogeneity or segregation of microbial populations has been the subject of much research, but the real impact of this phenomenon on bioprocesses remains not well understood. The main reason behind this ... [more ▼]

Heterogeneity or segregation of microbial populations has been the subject of much research, but the real impact of this phenomenon on bioprocesses remains not well understood. The main reason behind this lack of knowledge is the difficulty for monitoring microbial population heterogeneity in dynamic process conditions. The main concepts leading to microbial population heterogeneity in the context of bioprocesses have been summarized by two distinct hypotheses. The first one involves the individual history of microbial cells or “path” followed during their residence time inside process equipment. The second one involves a coordinated response of the microbial population as a bet-hedging strategy in order to cope with process-related stresses. The respective contribution of each hypothesis to microbial heterogeneity in bioprocesses is still unclear. This statement illustrates the fact that, although microbial phenotypic heterogeneity has been thoroughly investigated at the fundamental level, the implications of this phenomenon in the context of microbial bioprocesses are still subjected to debate. At this time, automated flow cytometry is the best technique for the investigation of microbial heterogeneity in process conditions. However, dedicated software and relevant biomarkers are needed for its proper integration as a bioprocess control tool. [less ▲]

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See detailEvaluation of Adherence to a Convulsion management Protocol for Children in Rwanda
kaputu-kalal-malu, Célestin; D'Amour Birindabagabo, Jean; Walker, Timothy David et al

in Journal of Tropical Pediatrics (2014), 60(2), 124-128

Inappropriate seizure management may result in high morbidity and mortality. We assessed the adherence of health professionals in southern Rwanda to a national protocol for pharmacological management of ... [more ▼]

Inappropriate seizure management may result in high morbidity and mortality. We assessed the adherence of health professionals in southern Rwanda to a national protocol for pharmacological management of seizures in children. A questionnaire featuring a 5-year-old child with generalized prolonged seizures was administered. The questions focused on the choice of initial treatment and the sequence of management following failure of the initial treatment choice. Benzodiazepine was chosen as initial therapy by 93.7% of physicians and 90.9% of nurses. Only 49.2% of physicians and 41% of nurses would repeat the initial treatment in case of failure of the first dose and 47% of doctors would wait 30 min to intervene. In case of refractory status epilepticus, 34% of physicians would give three doses of benzodiazepine, whereas 19% did not know what to do. These results suggest poor adherence to national protocol. [less ▲]

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See detailLignin extraction from Mediterranean agro-wastes: Impact of pretreatment conditions on lignin chemical structure and thermal degradation behavior
Manara, Panagiota; Zabaniotou, Anastasia; Vanderghem, Caroline ULg et al

in Catalysis Today (2014), 223

Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical ... [more ▼]

Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical one. The organosolv process included lignocellulosic biomass treatment with formic acid/acetic acid/water (30/50/20, v/v%), for 3 h at 107 °C, while the physicochemical method was conducted by immersing the biomass in a water/ethanol (8/92, v/v%), H2SO4 0.32 M, solvent and further exposing the slurry to microwave irradiation (maximum 250 W) for 1/2 h at 150 °C. Both processes were evaluated regarding the achieved delignification and the purity of the extracted lignins. The effect of the pretreatment processes onto the structure and thermal decomposition behavior of the extracted lignins was investigated via FT-IR and TGA analysis, respectively. The objective of the research work was to investigate potential valorization routes for these biomass agro-residues in the context of a biorefinery, focusing on lignin extraction. The pretreatment results showed that the obtained lignins, derived from both procedures, were of high purity (>82 wt%). Under the organosolv procedure, peach kernel delignification showed the maximum value (∼16 wt%), while under microwave pretreatment, olive kernel delignification showed the maximum value (∼35 wt%). Grape pomace/seeds appeared to be the most resistant in both treatments. [less ▲]

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See detailConnecting the dots for social value: A review on social networks and social entrepreneurship
Dufays, Frédéric ULg; Huybrechts, Benjamin ULg

in Journal of Social Entrepreneurship (2014), 5(2), 214-237

The emergence of social entrepreneurship has been explained at the macro-level (socioeconomic drivers), at the meso-level (concepts such as opportunity), and at the micro-level (motivations and intentions ... [more ▼]

The emergence of social entrepreneurship has been explained at the macro-level (socioeconomic drivers), at the meso-level (concepts such as opportunity), and at the micro-level (motivations and intentions of social entrepreneurs). In this conceptual article, it is argued that the sociology of social networks may contribute to explain how and why social entrepreneurship arises by bridging micro- and macro-levels of analysis. Four different usages of the social network concept in the social entrepreneurship literature are identified: embeddedness of social entrepreneurship, collective social entrepreneurship, networking as a critical skill or activity of social entrepreneurship, and finally networking and the creation of social capital as a goal of social entrepreneurship. Theoretical frameworks explaining the emergence of conventional entrepreneurship with a social network lens are identified. These are evaluated with regard to social entrepreneurship and translated into a set of research proposals to be explored in order to strengthen our understanding of social entrepreneurship emergence. [less ▲]

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See detailAntioxidant capacity of hydrophilic food matrices: optimization and validation of ORAC assay.
Kevers, Claire ULg; Sipel, Arnaud; PINCEMAIL, Joël ULg et al

in Food Analytical Methods (2014), 7

It is widely accepted that ORAC is a useful method for assessing food extracts that contain various antioxidants. The principal aim of this study was to validate the ORAC assay. We first identified ... [more ▼]

It is widely accepted that ORAC is a useful method for assessing food extracts that contain various antioxidants. The principal aim of this study was to validate the ORAC assay. We first identified parameters that can interfere with the ORAC assay and we optimized it. Then, experiments were conducted to determine the limits of linearity and response function, to determine the accuracy profiles to circumvent some of the drawbacks of traditional validation procedures. Trueness, selectivity and limits of quantification of the method were also determined. Our objective of ORAC method validation is thus to give guarantees that most of the results generated during use of this method will be close enough to unknown true value of antioxidant capacity of food matrices. The validation results indicate that the described method will give accurate and reliable results for Trolox equivalent values ranging from 50 to 200 µmol/L. [less ▲]

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See detailInflammation as a link between obesity, metabolic syndrome and type 2 diabetes
ESSER, Nathalie ULg; Legrand, Sylvie ULg; Piette, Jacques ULg et al

in Diabetes Research & Clinical Practice (2014)

It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic ... [more ▼]

It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose tissue, liver, muscle and pancreas are themselves sites of inflammation in presence of obesity. An infiltration of macrophages and other immune cells is observed in these tissues associated with a cell population shift from an anti-inflammatory to a pro-inflammatory profile. These cells are crucial for the production of pro-inflammatory cytokines, which act in an autocrine and paracrine manner to interfere with insulin signaling in peripheral tissues or induce β-cell dysfunction and subsequent insulin deficiency. Particularly, the pro-inflammatory interleukin-1β is implicated in the pathogenesis of type 2 diabetes through the activation of the NLRP3 inflammasome. The objectives of this review are to expose recent data supporting the role of the immune system in the pathogenesis of insulin resistance and type 2 diabetes and to examine various mechanisms underlying this relationship. If type 2 diabetes is an inflammatory disease, anti-inflammarory therapies could have a place in prevention and treatment of type 2 diabetes. [less ▲]

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See detailRediscovery of the forgotten de Ryckholt Collection (gastropods, bivalves, worms; Late Cretaceous, Belgium)
Denayer, Julien ULg; Fischer, Valentin ULg; Mottequin, Bernard ULg

in Cretaceous Research (2014), 47

A significant part of the collection of mid- and Late Cretaceous (Cenomanian, Campanian and Maastrichtian) gastropods, bivalves and worms described and/or illustrated by de Ryckholt in his seminal work ... [more ▼]

A significant part of the collection of mid- and Late Cretaceous (Cenomanian, Campanian and Maastrichtian) gastropods, bivalves and worms described and/or illustrated by de Ryckholt in his seminal work Mélanges paléontologiques between 1854 and 1862, has recently been retraced in the historical collections at Liège University. Of the original collection, more than 206 specimens, including 196 nominal types (lectotypes and genotypes), all considered lost, are now available. The genotypes of the gastropod genera Tudicula de Ryckholt, 1862a and Prosopostoma de Ryckholt, 1862a are photographically illustrated for the first time. Prosopostoma bucculans, from the Cenomanian Bernissart Formation (formerly ‘Tourtia de Tournai’), is here chosen as the type species of the genus Prosopostoma, a possible stromboid. We also reassess the stratigraphic age of the type localities under the revised stratigraphic framework of Belgium and a detailed account on the research history of this material, in order to provide a thorough scientific background for future study of this formidable collection. [less ▲]

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See detailSeasonal and depth-related biodiversity of leaf epiphytic Cheilostome Bryozoa in a Mediterranean Posidonia oceanica meadow
Lepoint, Gilles ULg; Balancier, Boris; Gobert, Sylvie ULg

in Cahiers de Biologie Marine (2014), 55(1),

: Epiphytes living fixed on Posidonia oceanica L. (Delile) are important faunal and floral components of seagrass meadow ecosystems. They are involved as main actors in trophic web and major ecosystem ... [more ▼]

: Epiphytes living fixed on Posidonia oceanica L. (Delile) are important faunal and floral components of seagrass meadow ecosystems. They are involved as main actors in trophic web and major ecosystem processes of this endangered coastal habitat. This paper aims to assess the seasonality and the bathymetric variability of epiphytic Bryozoa which are the most important animal group in terms of both diversity and abundance living on P. oceanica leaves. Posidonia shoots were collected from the Revellata Bay (Corsica, France) in four seasons from 7 to 30 m depth. Colony densities reached more than 87000 colonies. m-2 at 10 m depth in spring. The bryozoan species distribution and abundance changed substantially according to seasons and depths, being maximum in spring and minimal in winter. Dominant colony morphotypes change according to depth, probably in relation with water motion gradient. This confirms that there are bathymetric and seasonal variability for different epiphytic organisms colonizing the Posidonia leaves. This enlightens the importance to protect Posidonia meadow on its full depth extension and in its connectivity with other habitats to conserve optimal epiphytic biodiversity and functions. [less ▲]

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See detailSynthese bibliographique de l'influence du procédé d'extraction et de purification sur les caractéristiques et les propriétés d'une gomme de caroube
Gillet, Sébastien ULg; Simon, mathilde; Paquot, Michel ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(1),

The carob tree is a species cultivated, in mediterranean countries, for its seeds. These seeds contain an endosperm rich in galactomannans used by the food industry for its texturing properties. After ... [more ▼]

The carob tree is a species cultivated, in mediterranean countries, for its seeds. These seeds contain an endosperm rich in galactomannans used by the food industry for its texturing properties. After harvesting, the seeds pass through a decutilation and a degermination. Cleaned endosperms are then milled to give crude locust bean gum. The purification step consists in a flour solubilization and then a precipitation of the galactomannans. Purification influences the characteristics of the resulting gum. The solubilization temperature is the parameter that affects the most on the final characteristics of the product. If it is hot or cold, galactomannans with different structural characteristics (and thus very different physical properties in aqueous solutions) will be selected. [less ▲]

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See detailExpression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis
CREVECOEUR, Julie ULg; Kaminski, RM; Rogister, Bernard ULg et al

in Neuropathology & Applied Neurobiology (2014), 40(2), 191-204

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See detailFrom reporting incidents in a radiation therapy department to enterprise risk management (ERM) based on the European Foundation for Quality Management philosophy (EFQM)
COUCKE, Philippe ULg; BOGA, Deniz ULg; LENAERTS, Eric ULg et al

in International Journal of Healthcare Technology & Management (2014), 7(2), 127-131

The radiation therapy department (RTD) initiated in 2009 a policy of open and transparent reporting of events not harming (near incidents) and potentially harming patients (incidents and accidents). This ... [more ▼]

The radiation therapy department (RTD) initiated in 2009 a policy of open and transparent reporting of events not harming (near incidents) and potentially harming patients (incidents and accidents). This approach was immediately followed by the leader’s decision to engage towards the European Foundation for Quality Management (EFQM) excellence model. The EFQM approach structured the journey of the RTD to enterprise risk management. We intend to demonstrate in the five main fields of the EFQM approach (leadership, policy and strategy, people/personnel, partnership and resources, processes), how the journey to continuous improvement in quality and safety did evolve and was accelerated in RTD. The assessment made by external evaluators evolved from a minimum of 90 points (basic requirement for level 1 in 2009) to a at least 180 points (basic requirement for level 2 in 2011), to reach 400 points in 2013 (270 required for level 3 and 450 required for level 4). [less ▲]

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See detailEffects of glucose-lowering agents on vascular outcomes in type 2 diabetes: A critical reappraisal.
Scheen, André ULg; Charbonnel, B.

in Diabetes & metabolism (2014)

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major ... [more ▼]

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain how hyperglycaemia induces vascular damage. However, randomized controlled trials investigating either an intensive glucose-lowering strategy vs standard care or the addition of a new glucose-lowering agent vs a placebo have largely failed to demonstrate any clinical benefits in terms of cardiovascular morbidity or mortality. This lack of evidence has led some people to contest the clinical efficacy of lowering blood glucose in patients with T2DM, despite its positive effects on microvascular complications. This article analyzes the various reasons that might explain such discrepancies. There are still strong arguments in favour of targeting hyperglycaemia while avoiding other counterproductive effects, such as hypoglycaemia and weight gain, and of integrating the glucose-lowering approach within a global multi-risk strategy to reduce the burden of cardiovascular disease in T2DM. [less ▲]

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See detailOn the policy implications of changing longevity
Pestieau, Pierre ULg; Ponthiere, Grégory ULg

in CESifo Ecoonmic Studies (2014), 60

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See detailLa dermatoporose, un "vintage" de l'atrophodermie et de la "peau transparente".
FRANCHIMONT, Claudine ULg; Hermanns, J.F.; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2014), 69

Le vieillissement de la peau se marque à terme par une atrophodermie, parfois sévère. La corticothérapie, qu’elle soit systémique ou topique, exerce un effet atrophiant qui copie l’effet du grand âge. Cet ... [more ▼]

Le vieillissement de la peau se marque à terme par une atrophodermie, parfois sévère. La corticothérapie, qu’elle soit systémique ou topique, exerce un effet atrophiant qui copie l’effet du grand âge. Cet état d’atrophodermie a été décrit comme la «peau transparente» il y a une quarantaine d’années, et il a reçu plus récemment la nouvelle dénomination de dermatoporose. Il est connu de longue date que cet état entraîne des conséquences cliniques parfois majeures qui conduisent à des lésions diverses sous forme de purpura de Bateman, de cicatrices stellaires, et de plaies faisant suite à des traumatismes mineurs. [less ▲]

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See detailQualité de vie de l’enfant avec antécédents oncologiques et adaptation parentale : étude exploratoire
Tilkin, Caroline; Toucheque, Malorie ULg; Missotten, Pierre ULg et al

in Revue Médicale de Liège (2014)

Cette étude envisage la qualité de vie (QV) de l’enfant avec antécédents oncologiques et celle de ses parents ainsi que la relation entre l’adaptation parentale et la QV de l’enfant. Deux groupes ont été ... [more ▼]

Cette étude envisage la qualité de vie (QV) de l’enfant avec antécédents oncologiques et celle de ses parents ainsi que la relation entre l’adaptation parentale et la QV de l’enfant. Deux groupes ont été créés : un groupe expérimental composé d’enfants avec antécédents oncologiques et leurs parents et un groupe contrôle composé d’enfants tout-venant appariés et de leurs parents. Les enfants ont rempli un questionnaire de QV; les parents ont complété des questionnaires évaluant les stratégies de coping, les représentations de la maladie, le stress parental et la QV. Les résultats montrent que la QV du groupe expérimental est satisfaisante et similaire à celle observée au sein du groupe contrôle. Les représentations des parents (menace et contrôle personnel), ainsi que les stratégies qu’ils mettent en place pour maintenir l’intégration familiale sont significativement liées à la QV de leur enfant. Cette étude met en évidence le besoin d’évaluer l’adaptation des parents d’enfant avec antécédents oncologiques et de développer des interventions ciblant leurs représentations et leurs stratégies de coping. [less ▲]

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See detailHigh-energy X-ray tomography analysis of a metal packing biofilm reactor for the production of lipopeptides by Bacillus subtilis
Zune, Quentin ULg; Soyeurt, Delphine; Toye, Dominique ULg et al

in Journal of Chemical Technology & Biotechnology (2014), 89

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the ... [more ▼]

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the production of high-value metabolites. Technically, this new concept relies on the design of bioreactors able to promote biofilm formation and on the identification of the key physico-chemical parameters involved in biofilm formation. RESULTS: An experimental setting comprising a liquid continuously recirculated on a metal structured packing has been used to promote Bacillus subtilis GA1 biofilm formation. The colonization of the packing has been visualized non-invasively by X-ray tomography. This analysis revealed an uneven, conical, distribution of the biofilm inside the packing. Compared with a submerged culture carried out in a stirred tank reactor, significant modification of the lipopeptide profile has been observed in the biofilm reactorwith the disappearance of fengycin and iturin fractions and an increase of the surfactin fraction. In addition, considering the biofilm reactor design, no foam formation has been observed during the culture. CONCLUSIONS: The configuration of this biofilm reactor set-up allows for a higher surfactin production by comparison with a submerged culture while avoiding foam formation. Additionally, scale-up could easily be performed by increasing the number of packing elements. [less ▲]

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See detailSubspace-based identification of a nonlinear spacecraft in the time and frequency domains
Noël, Jean-Philippe ULg; Marchesiello, Stefano; Kerschen, Gaëtan ULg

in Mechanical Systems & Signal Processing (2014), 43(1-2), 217-236

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure. To this end, two nonlinear subspace identification methods formulated in the time and ... [more ▼]

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure. To this end, two nonlinear subspace identification methods formulated in the time and frequency domains are exploited, referred to as the TNSI and FNSI methods, respectively. The modal parameters of the underlying linear structure and the coefficients of the nonlinearities will be estimated by these two approaches based on periodic random measurements. Their respective merits will also be discussed in terms of both accuracy and computational efficiency and the use of stabilisation diagrams in nonlinear system identification will be introduced. The application of interest is the SmallSat spacecraft developed by EADS-Astrium, which possesses an impact-type nonlinear device consisting of eight mechanical stops limiting the motion of an inertia wheel mounted on an elastomeric interface. This application is challenging for several reasons including the non-smooth nature of the nonlinearities, high modal density and high non-proportional damping. [less ▲]

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See detailCombined effects of climate, resource availability, and plant traits on biomass produced in a Mediterranean rangeland
Chollet, Simon; Rambal, Serge; Fayolle, Adeline ULg et al

in Ecology (2014), 95(3), 737-748

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities ... [more ▼]

Biomass production in grasslands, a key component of food provision for domestic herbivores, is known to depend on climate, resource availability, and on the functional characteristics of communities. However, the combined effects of these different factors remain largely unknown. The aim of the present study was to unravel the causes of variations in the standing biomass of plant communities using a long-term experiment conducted in a Mediterranean rangeland of Southern France. Two management regimes, sheep grazing and grazing associated with mineral fertilization, were applied to different areas of the study site over the past 25 years. Abiotic (temperature, available water, nutrients) and biotic (components of the functional structure communities) factors were considered to explain interannual and spatial variations in standing biomass in these rangelands. Standing biomass was highly predictable, with the best model explaining ;80% of variations in the amount of biomass produced, but the variation explained by abiotic and biotic factors was dependent on the season and on the management regime. Abiotic factors were found to have comparable effects in both management regimes: The amount of biomass produced in the spring was limited by cold temperatures, while it was limited by water availability and high temperatures in the summer. In the fertilized community, the progressive change in the functional structure of the communities had significant effects on the amount of biomass produced: the dominance of few productive species which were functionally close led to higher peak standing biomass in spring. [less ▲]

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See detailÉduquer à la démocratie : Protagoras et la question de l’égalité
Gavray, Marc-Antoine ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2014)

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See detailCalcium, phosphorus, magnesium and vitamin D requirements of the preterm infants
Mimouni, F; Mandel, D; Lubetzky, R et al

in World Review of Nutrition and Dietetics (2014), 110

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See detailPharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor.
Scheen, André ULg

in Clinical pharmacokinetics (2014), 53(3), 213-25

Empagliflozin is an orally active, potent and selective inhibitor of sodium glucose co-transporter 2 (SGLT2), currently in clinical development to improve glycaemic control in adults with type 2 diabetes ... [more ▼]

Empagliflozin is an orally active, potent and selective inhibitor of sodium glucose co-transporter 2 (SGLT2), currently in clinical development to improve glycaemic control in adults with type 2 diabetes mellitus (T2DM). SGLT2 inhibitors, including empagliflozin, are the first pharmacological class of antidiabetes agents to target the kidney in order to remove excess glucose from the body and, thus, offer new options for T2DM management. SGLT2 inhibitors exert their effects independently of insulin. Following single and multiple oral doses (0.5-800 mg), empagliflozin was rapidly absorbed and reached peak plasma concentrations after approximately 1.33-3.0 h, before showing a biphasic decline. The mean terminal half-life ranged from 5.6 to 13.1 h in single rising-dose studies, and from 10.3 to 18.8 h in multiple-dose studies. Following multiple oral doses, increases in exposure were dose-proportional and trough concentrations remained constant after day 6, indicating a steady state had been reached. Oral clearance at steady state was similar to corresponding single-dose values, suggesting linear pharmacokinetics with respect to time. No clinically relevant alterations in pharmacokinetics were observed in mild to severe hepatic impairment, or in mild to severe renal impairment and end-stage renal disease. Clinical studies did not reveal any relevant drug-drug interactions with several other drugs commonly prescribed to patients with T2DM, including warfarin. Urinary glucose excretion (UGE) rates were higher with empagliflozin versus placebo and increased with dose, but no relevant impact on 24-h urine volume was observed. Increased UGE resulted in proportional reductions in fasting plasma glucose and mean daily glucose concentrations. [less ▲]

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See detailPrevalence of Campylobacter among goats and retail goat meat in Congo
Kabwang a Mpalang, Rosette; BOREUX, Raphaël ULg; Melin, Pierrette ULg et al

in Journal of Infection in Developing Countries [=JIDC] (2014), 8

Background: The prevalence of Campylobacter jejuni and Campylobacter coli was determined in goat and goat meat sold at retail outlets in Lubumbashi, Democratic Republic of Congo (DR Congo). Methodology: A ... [more ▼]

Background: The prevalence of Campylobacter jejuni and Campylobacter coli was determined in goat and goat meat sold at retail outlets in Lubumbashi, Democratic Republic of Congo (DR Congo). Methodology: A total of 644 samples, including 177 goat meat, 86 goat stomachs, 139 ready to eat (RTE) goat skewers, and 242 goat faecal samples were examined for the presence of Campylobacter jejuni and Campylobacter coli using polymerase chain reaction. Results: Overall, Campylobacter spp. were found in 34.6% of the examined samples. C. jejuni was isolated in 10.1% and C. coli in 26.7% of samples. Only 2.2% of all samples were positive for both species. There was a significant association between the prevalence of C. coli and the type of sample (p < 0.05). The overall prevalence of Campylobacter in different sample groups was 41.2%, 37.2%, 23.7%, and 35.1% for goat meat, goat stomachs, RTE goat skewers, and goat faecal samples, respectively. There was no significant difference (p > 0.05) between the prevalence observed in the rainy season (16.7%) and the dry season (20.0%). Moreover, the overall prevalence of Campylobacter in slaughter sites, open-air markets, warehouses, and semi-open-air markets was 28.2%, 34.2%, 35.4%, and 42.9%, respectively. Statistically, there was no influence of the sample collection site on the frequency of isolation of Campylobacter (p > 0.05). Conclusion: This study shows that, considering the relatively high prevalence of this [less ▲]

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See detailHigher Symmetries of the Laplacian via Quantization
Michel, Jean-Philippe ULg

in Annales de l'Institut Fourier (2014), 64

We develop a new approach, based on quantization methods, to study higher symmetries of invariant di erential operators. We focus here on conformally invariant powers of the Laplacian over a conformally ... [more ▼]

We develop a new approach, based on quantization methods, to study higher symmetries of invariant di erential operators. We focus here on conformally invariant powers of the Laplacian over a conformally at manifold and recover results of Eastwood, Leistner, Gover and ilhan. In particular, conformally equivariant quantization establishes a correspondence between the algebra of Hamiltonian symmetries of the null geodesic ow and the algebra of higher symmetries of the conformal Laplacian. Combined with a symplectic reduction, this leads to a quantization of the minimal nilpotent coadjoint orbit of the conformal group. The star-deformation of its algebra of regular functions is isomorphic to the algebra of higher symmetries of the conformal Laplacian. Both identify with the quotient of the universal envelopping algebra by the Joseph ideal. [less ▲]

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See detailThe retirement of the migrant labor force: pension portability and beyond
Jousten, Alain ULg

in CESifo Economic Studies (2014)

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – ... [more ▼]

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – system sustainability or distributive characteristics. The present paper provides a fresh look at the nexus between these two literatures. It discusses the impact of the European social security coordination mechanisms on individual decision-making and on the functioning of social security systems – with a focus on retirement. The paper argues that such effects are non-negligible and are likely to have major policy consequences. [less ▲]

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See detailCompte-rendu de l'ouvrage de P. Pérez del Solar: Imágenes del desencanto: nueva historieta española
Ceballos Viro, Alvaro ULg

in Iberoamericana America Latina-Espana-Portugal (2014), (53), 220-222

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