References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLa politique étrangère de l’Italie face aux débuts de la crise congolaise. Pour une histoire des intérêts italiens au Congo dans les années 1960
Genin, Vincent ULg

in Forum Romanum Belgicum. E-Revue de l’Institut Historique Belge de Rome (successeur du Bulletin de L’Institut Historique Belge de Rome) (2013)

Detailed reference viewed: 29 (8 ULg)
Full Text
Peer Reviewed
See detailIn Vitro Synergy of Polymyxins and Carbapenems: Systematic Review and Meta Analysis.
Zusman, Oren; Avni, Tomer; Leibovici, Leonard et al

in Antimicrobial Agents and Chemotherapy (2013), 57(10), 5104-51011

ObjectivesTo examine the evidence on in-vitro synergy of polymyxin-carbapenem combination therapy against Gram-negative bacteria (GNB)MethodsSystematic review and meta-analysis. All studies examining in ... [more ▼]

ObjectivesTo examine the evidence on in-vitro synergy of polymyxin-carbapenem combination therapy against Gram-negative bacteria (GNB)MethodsSystematic review and meta-analysis. All studies examining in-vitro interactions of antibiotic combinations consisting of any carbapenem with colistin or polymyxin B against any GNB. A broad search was conducted with no language, date or publication status restrictions. Synergy rates, defined as fractional inhibitory concentration index </=0.5 or >2log colony forming unit reduction, were pooled separately for time-kill, checkerboard, and E-test in a mixed-effects meta-analysis of rates. We examined whether synergy rate depended on testing method, type of antibiotic, bacteria and resistance to carbapenems. Pooled rates with 95% confidence intervals are shown.Results39 published studies and 15 conference proceeding were included, reporting on 246 different tests on 1054 bacterial isolates. In time-kill studies, combination therapy showed synergy rates of 77% (95% CI 64-87) for Acinetobacter baumannii, 44% (95% CI 30-59%) for Klebsiella pneumoniae and 50% (95% CI 30-69%) for Pseudomonas aeruginosa with low antagonism rates for all. Doripenem showed high synergy rates for all three bacteria. For A. baumannii, meropenem was more synergistic than imipenem, whereas for P. aeruginosa the opposite was true. Checkerboard and Etest studies generally reported lower synergy rates than time-kill. Use of combination therapy led to less resistance development in-vitro.ConclusionsThe combination of a carbapenem with a polymyxin against GNB, especially A. baumannii, is supported in-vitro by high synergy rates, with low antagonism and less resistance development. These findings should be examined in clinical studies. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailIDS iSYS automated intact procollagen-1-Nterminus pro-peptide assay: method evaluation and reference intervals in adults and children
Morovat, Alireza; Catchpole, Anthony; MEURISSE, Angélique ULg et al

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 2009-2018

Background: We carried out a technical evaluation of the Immunodiagnostic Systems (IDS) automated intact procollagen- I N-terminus propeptide (PINP) assay on the iSYS platform, and established reference ... [more ▼]

Background: We carried out a technical evaluation of the Immunodiagnostic Systems (IDS) automated intact procollagen- I N-terminus propeptide (PINP) assay on the iSYS platform, and established reference intervals for PINP in both adults and children. Methods: Assay imprecision, recovery and interference were studied. Serum and plasma values were compared, and PINP stability was assessed. Using 828 specimens, IDS iSYS intact PINP and Roche E170 total PINP values were compared. Specimens from 597 adults and 485 children and adolescents were used to establish reference intervals for intact PINP. Results: The method demonstrated good recovery and acceptable imprecision. The assay was unaffected by icterus and lipaemia, but haemolysis decreased measured PINP. Serum and plasma values were comparable. There was a non-linear relation between IDS intact and Roche total PINP values. Pre- and post-menopausal women had comparable PINP values, but there was a difference between women of different age groups. Serum PINP in men showed a decline in young age up to 45 years, but remained steady thereafter. Separate reference intervals were established for four age groups in women and for two age groups in men. Data for children were partitioned into four-year age groups, and these showed PINP to be high with no major gender differences until 12 years of age. Thereafter, values in females decreased in 13–16 years age groups and further in 17–20 years age groups, whereas PINP increased in boys of 13–16 years of age with a subsequent decline at 17–20 years. Conclusions: The IDS iSYS PINP intact assay appears to be reliable. We have established gender- and age-related reference intervals for children and adults based on a relatively large healthy North European population. [less ▲]

Detailed reference viewed: 37 (13 ULg)
Full Text
Peer Reviewed
See detailLes mécanismes de coordination des finances publiques en Belgique dans le cadre e la nouvelle gouvernance budgétaire européenne
Uhoda, Maxime ULg; Bourgeois, Marc ULg; Bayenet, Benoît

in Revue de Fiscalité Régionale et Locale (2013), 3(2013), 206-226

Detailed reference viewed: 23 (1 ULg)
Full Text
Peer Reviewed
See detailA rich internet application for remote visualization and collaborative annotation of digital slide images in histology and cytology
Marée, Raphaël ULg; Stevens, Benjamin ULg; Rollus, Loïc ULg et al

in Diagnostic Pathology (2013), 8(S1), 26

This work proposes a new web-based tool to ease collaborative projects in digital histology and cytology.

Detailed reference viewed: 107 (38 ULg)
Full Text
Peer Reviewed
See detailAerial surveys using an Unmanned Aerial System (UAS): comparison of different methods for estimating the surface area of sampling strips
Lisein, Jonathan ULg; Linchant, Julie ULg; Lejeune, Philippe ULg et al

in Tropical Conservation Science (2013), 6(4), 506-520

Conservation of natural ecosystems requires regular monitoring of biodiversity, including the estimation of wildlife density. Recently, unmanned aerial systems (UAS) have become more available for ... [more ▼]

Conservation of natural ecosystems requires regular monitoring of biodiversity, including the estimation of wildlife density. Recently, unmanned aerial systems (UAS) have become more available for numerous civilian applications. The use of small drones for wildlife surveys as a surrogate for manned aerial surveys is becoming increasingly attractive and has already been implemented with some success. This raises the question of how to process UAS imagery in order to determine the surface area of sampling strips within an acceptable confidence level. For the purpose of wildlife surveys, the estimation of sampling strip surface area needs to be both accurate and quick, and easy to implement. As GPS and an inertial measurement units are commonly integrated within unmanned aircraft platforms, two methods of direct georeferencing were compared here. On the one hand, we used the image footprint projection (IFP) method, which utilizes collinearity equations on each image individually. On the other hand, the Structure from Motion (SfM) technique was used for block orientation and georeferencing. These two methods were compared on eight sampling strips. An absolute orientation of the strip was determined by indirect georeferencing using ground control points. This absolute orientation was considered as the reference and was used for validating the other two methods. The IFP method was demonstrated to be the most accurate and the easiest to implement. It was also found to be less demanding in terms of image quality and overlap. However, even though a flat landscape is the type most widely encountered in wildlife surveys in Africa, we recommend estimating IFP sensitivity at an accentuation of the relief. [less ▲]

Detailed reference viewed: 196 (20 ULg)
Full Text
Peer Reviewed
See detailMicro-crédit, Augmentation du pouvoir d’achat et Amélioration des conditions de vie des populations précaires en milieu urbain africain : Résultats d’une expérience menée dans la zone de santé de Bandalungwa à Kinshasa, Congo.
Manzambi Kuwekita, Joseph ULg; Gosset, Christiane ULg; Guillaume, Michèle ULg et al

in Psychologie et Société Nouvelle (2013), XII(3), 3-14

Purchasing power increase, improvement of living conditions and health funding of vulnerable people in African urban areas: the case of the health zone of Bandalungwa, Kinshasa (Congo) Through a survey ... [more ▼]

Purchasing power increase, improvement of living conditions and health funding of vulnerable people in African urban areas: the case of the health zone of Bandalungwa, Kinshasa (Congo) Through a survey, the study analyses the living improvement possibilities for microentrepreneurs, by the improvement of their purchasing power through microcredits provided by the Programme National d’Appui à la Protection Sociale (PNPS), in the health zone of Bandalungwa (Kinshasa). The credits were affected to wheat flour, starches, fresh food, fruits and vegetables, small restoration, smoked fish, clothing, electronic devices. Main results suggest that 68% of the microentrepreneurs financed by the program have declared improved living conditions. This improvement was associated to access to health care, children schooling, household’s access to food, loan reimbursement, and rent payment. The bivariate analysis has shown that those who had invested the whole credit in the funded activity experienced living improvement. To help vulnerable people in increasing their purchasing power, the loans should be linked to projects that are helpful to the households, and avoid that households use the credit in unsuitable ways, which could maintain them in a high level of debt. [less ▲]

Detailed reference viewed: 40 (13 ULg)
Full Text
Peer Reviewed
See detailCatalogue of particle-accelerating colliding-wind binaries
De Becker, Michaël ULg; Raucq, Françoise ULg

in Astronomy and Astrophysics (2013), 558

Massive systems made of two or more stars are known to be the site for interesting physical processes -- including at least in some cases -- particle acceleration. Over the past decade, this topic ... [more ▼]

Massive systems made of two or more stars are known to be the site for interesting physical processes -- including at least in some cases -- particle acceleration. Over the past decade, this topic motivated a particular effort to unveil the properties of these systems and characterize the circumstances responsible for the acceleration of particles and the potential role of pre-supernova massive stars in the production of high energy particles in our Galaxy. Although previous studies on this topic were mostly devoted to processes in general, or to a few individual objects in particular, a unified target-oriented census of particle-accelerating colliding-wind binaries (hereafter PACWBs) does not exist yet. This paper aims at making a general and unified census of these systems, emphasizing their main properties. A general discussion includes energetic considerations along with wind properties in relation with non-thermal emission processes that are likely at work in colliding-wind binaries. Finally, some guidelines for future observational and theoretical studies are drawn. [less ▲]

Detailed reference viewed: 29 (5 ULg)
Full Text
Peer Reviewed
See detailBaker's yeast behavior during vacuum agitated contact drying
Bennamoun, Lyes ULg; Afzal, Muhammad; Léonard, Angélique ULg

in Chemical Engineering and Technology (2013), 36(10), 1795-1800

Detailed reference viewed: 24 (5 ULg)
Full Text
Peer Reviewed
See detailA Comparison of Two Spelling Brain-Computer Interfaces Based on Visual P3 and SSVEP in Locked-In Syndrome
Combaz, Adrien; Chatelle, Camille ULg; Robben, Arne et al

in PLoS ONE (2013), 8(9), 73691

Objectives: We study the applicability of a visual P3-based and a Steady State Visually Evoked Potentials (SSVEP)-based Brain-Computer Interfaces (BCIs) for mental text spelling on a cohort of patients ... [more ▼]

Objectives: We study the applicability of a visual P3-based and a Steady State Visually Evoked Potentials (SSVEP)-based Brain-Computer Interfaces (BCIs) for mental text spelling on a cohort of patients with incomplete Locked-In Syndrome (LIS). Methods: Seven patients performed repeated sessions with each BCI. We assessed BCI performance, mental workload and overall satisfaction for both systems. We also investigated the effect of the quality of life and level of motor impairment on the performance. Results: All seven patients were able to achieve an accuracy of 70% or more with the SSVEP-based BCI, compared to 3 patients with the P3-based BCI, showing a better performance with the SSVEP BCI than with the P3 BCI in the studied cohort. Moreover, the better performance of the SSVEP-based BCI was accompanied by a lower mental workload and a higher overall satisfaction. No relationship was found between BCI performance and level of motor impairment or quality of life. Conclusion:Our results show a better usability of the SSVEP-based BCI than the P3-based one for the sessions performed by the tested population of locked-in patients with respect to all the criteria considered. The study shows the advantage of developing alternative BCIs with respect to the traditional matrix-based P3 speller using different designs and signal modalities such as SSVEPs to build a faster, more accurate, less mentally demanding and more satisfying BCI by testing both types of BCIs on a convenience sample of LIS patients. [less ▲]

Detailed reference viewed: 39 (7 ULg)
Full Text
Peer Reviewed
See detailThe role of wrist actigraphy in the evaluation and safety of patients in psychogeriatric ward
GILLAIN, Daniel ULg; Schyns, Edwin ULg; LEJEUNE, Christophe ULg et al

in European Geriatric Medicine (2013), 4(S1),

Detailed reference viewed: 23 (3 ULg)
Full Text
Peer Reviewed
See detailOptimization of Shipyard Space Allocation and Scheduling using Heuristic Algorithm
Caprace, Jean-David ULg; Petcu, Cristian ULg; Velarde, Marco et al

in Journal of Marine Science & Technology (2013), 18(3), 404-417

In this paper we describe the development of a tool that allows planners to efficiently and effectively plan space within valuable areas of a shipyard. Traditionally, space is considered as resource ... [more ▼]

In this paper we describe the development of a tool that allows planners to efficiently and effectively plan space within valuable areas of a shipyard. Traditionally, space is considered as resource; however, it is difficult to accurately account for and plan its consumption with the current planning software tools available. The spatial scheduling tool described in this paper can be used by planners to manually or automatically reserve space within the shipyard for construction of large blocks over the entire ship erection period. The software is coupled with a heuristic optimization solver which is inspired by an algorithm used for "3D bin-packing problems". The result is the ability to efficiently generate and compare multiple space allocation alternatives in a reduced time with the ultimate goal of maintaining the critical ship erection schedule. Better solution than manual or semi-automatic allocation of blocks can be obtained through the optimization module. [less ▲]

Detailed reference viewed: 30 (2 ULg)
Full Text
Peer Reviewed
See detailNatural spatial variability of algal endosymbiont density in the coral Acropora globiceps: a small-scale approach along environmental gradients around Moorea (French Polynesia)
Ladrière, Ophélie ULg; Penin, Lucie; Van Lierde, Elodie et al

in Journal of the Marine Biological Association of the United Kingdom (2013)

This study provides a baseline describing natural small scale variability of Symbiodinium density in the sentinel coral Acropora globiceps during the summer, under non-bleaching conditions. Spatial scales ... [more ▼]

This study provides a baseline describing natural small scale variability of Symbiodinium density in the sentinel coral Acropora globiceps during the summer, under non-bleaching conditions. Spatial scales investigated range from the colony scale (1–10 cm, i.e. among branches of the same colony) to the reef scale (1–10 km, i.e. among stations distributed over several locations and depths), at Moorea Island, French Polynesia. The coral–Symbiodinium symbiosis is a key process in scleractinian coral physiology, and Symbiodinium density provides an easy-to-measure and inexpensive biomarker of this symbiosis health. Spatial variability of three major environmental factors: light intensity, sedimentation and water motion was also assessed to evaluate their potential link with Symbiodinium density. Density of Symbiodinium did not significantly differ within colonies or among colonies within a station. However, a marked depth gradient was observed, showing increasing density with increasing depth and decreasing light intensity. These observations provide an interesting reference for forthcoming comparisons with disturbed conditions, such as bleaching events. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailNumerical simulation of the Roll forming of thin-walled sections and evaluation of corner strength enhancement
Rossi, Barbara ULg; Degée, Hervé ULg; Boman, Romain ULg

in Finite Elements in Analysis & Design (2013), 72

Cold roll forming modifies the mechanical properties of thin-walled profiles by strain hardening. The understanding of this phenomenon, which is rather good for profiles made of traditional construction ... [more ▼]

Cold roll forming modifies the mechanical properties of thin-walled profiles by strain hardening. The understanding of this phenomenon, which is rather good for profiles made of traditional construction steel, is mandatory for assessing the member resistance. Less information is however available for profiles made of materials exhibiting a pronounced degree of nonlinearity of the stress-strain curve such as high-strength and stainless steels. Current codes generally encounter difficulties for modelling this fabrication process because of the size of industrial mills. Indeed, accurate modelling of the continuous cold roll forming process using finite elements requires a huge number of elements leading to excessive CPU times. Therefore, modellers usually reduce the geometry of the formed sheet or increase the size of the finite elements, inducing a loss of accuracy in the results. In this work, the finite element software METAFOR is used to model cold roll forming of channel profiles made of high-strength and stainless steels. The numerical results, expressed in terms of corner strength enhancement versus radius–to–thickness ratio, are compared against an existing predictive model. [less ▲]

Detailed reference viewed: 98 (26 ULg)
Full Text
Peer Reviewed
See detailSilver nanowire networks: Physical properties and potential integration in solar cells
Langley, Daniel ULg; Giusti, Gael; Lagrange, Mélanie et al

in Solar Energy Materials & Solar Cells (2013)

With the growing interest in flexible electronics and the increased utilization of Indium Tin Oxide electrodes for display and photovoltaic applications the need for new materials is emerging. In this ... [more ▼]

With the growing interest in flexible electronics and the increased utilization of Indium Tin Oxide electrodes for display and photovoltaic applications the need for new materials is emerging. In this work we present the electro-optical properties of Ag nanowire networks as an alternative transparent conductive material. A comparison of different film deposition techniques is made and indicates that the properties of the network are independent of the fabrication method. Analysis of the electrical behavior as a function of nanowire density is made and compared with theoretical results as well as Monte Carlo simulations. Thermal annealing is shown to reduce the sheet resistance from 1000 Ω/sq to 8 Ω/sq; this reduction is achieved by local sintering of the nanowire junctions. Experimental optimization of Ag nanowire electrodes was undertaken and a peak in the electro-optical properties is observed at approximately 100 mg/m². Finally a discussion of the potential integration of Ag nanowire networks into solar cells is undertaken; we observe that these electrodes show promise as an emerging transparent conductive material, especially for flexible applications. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailHeight competition between Quercus petraea and Fagus sylvatica natural regeneration in mixed and uneven-aged stands
Ligot, Gauthier ULg; Balandier, Philippe; Fayolle, Adeline ULg et al

in Forest Ecology & Management (2013), 304

We monitored in situ natural regeneration in 23 uneven-aged stands. We modelled height growth in the regeneration of Quercus petraea and Fagus sylvatica. Beech saplings grew faster than oak saplings at ... [more ▼]

We monitored in situ natural regeneration in 23 uneven-aged stands. We modelled height growth in the regeneration of Quercus petraea and Fagus sylvatica. Beech saplings grew faster than oak saplings at all light levels. Oak gained greater benefit from direct radiation than did beech. Canopy opening is insufficient to promote oak over beech regeneration. [less ▲]

Detailed reference viewed: 59 (47 ULg)
Full Text
Peer Reviewed
See detailLarge-scale pattern of genetic differentiation within African rainforest trees: insights on the roles of ecological gradients and past climate changes on the evolution of Erythrophleum spp (Fabaceae)
Duminil, Jérôme; Brown, Richard P.; Ewédjè, Eben-Ezer BK. et al

in BMC Evolutionary Biology (2013), 13

Background: The evolutionary events that have shaped biodiversity patterns in the African rainforests are still poorly documented. Past forest fragmentation and ecological gradients have been advocated as ... [more ▼]

Background: The evolutionary events that have shaped biodiversity patterns in the African rainforests are still poorly documented. Past forest fragmentation and ecological gradients have been advocated as important drivers of genetic differentiation but their respective roles remain unclear. Using nuclear microsatellites (nSSRs) and chloroplast non-coding sequences (pDNA), we characterised the spatial genetic structure of Erythrophleum (Fabaceae) forest trees in West and Central Africa (Guinea Region, GR). This widespread genus displays a wide ecological amplitude and taxonomists recognize two forest tree species, E. ivorense and E. suaveolens, which are difficult to distinguish in the field and often confused. Results: Bayesian-clustering applied on nSSRs of a blind sample of 648 specimens identified three major gene pools showing no or very limited introgression. They present parapatric distributions correlated to rainfall gradients and forest types. One gene pool is restricted to coastal evergreen forests and corresponds to E. ivorense; a second one is found in gallery forests from the dry forest zone of West Africa and North-West Cameroon and corresponds to West-African E. suaveolens; the third gene pool occurs in semi-evergreen forests and corresponds to Central African E. suaveolens. These gene pools have mostly unique pDNA haplotypes but they do not form reciprocally monophyletic clades. Nevertheless, pDNA molecular dating indicates that the divergence between E. ivorense and Central African E. suaveolens predates the Pleistocene. Further Bayesian-clustering applied within each major gene pool identified diffuse genetic discontinuities (minor gene pools displaying substantial introgression) at a latitude between 0 and 2°N in Central Africa for both species, and at a longitude between 5° and 8°E for E. ivorense. Moreover, we detected evidence of past population declines which are consistent with historical habitat fragmentation induced by Pleistocene climate changes. Conclusions: Overall, deep genetic differentiation (major gene pools) follows ecological gradients that may be at the origin of speciation, while diffuse differentiation (minor gene pools) are tentatively interpreted as the signature of past forest fragmentation induced by past climate changes. [less ▲]

Detailed reference viewed: 18 (4 ULg)
Full Text
Peer Reviewed
See detailMilli-interacting dark matter
Wallemacq, Quentin ULg

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2013), 88(6),

We present a dark matter model reproducing well the results from DAMA/LIBRA and CoGeNT and having no contradiction with the negative results from XENON100 and CDMS-II/Ge. Two new species of fermions F and ... [more ▼]

We present a dark matter model reproducing well the results from DAMA/LIBRA and CoGeNT and having no contradiction with the negative results from XENON100 and CDMS-II/Ge. Two new species of fermions F and G form hydrogenlike atoms with standard atomic size through a dark U(1) gauge interaction carried out by a dark massless photon. A Yukawa coupling between the nuclei F and neutral scalar particles S induces an attractive shorter-range interaction. This dark sector interacts with our standard particles because of the presence of two mixings, a kinetic photon–dark photon mixing, and a mass σ-S mixing. The dark atoms from the halo diffuse elastically in terrestrial matter until they thermalize and then reach underground detectors with thermal energies, where they form bound states with nuclei by radiative capture. This causes the emission of photons that produce the signals observed by direct-search experiments. [less ▲]

Detailed reference viewed: 23 (5 ULg)
Full Text
Peer Reviewed
See detailUse of response surface methodology for the optimization of the lipase-catalyzed synthesis of mannosyl myristate in pure ionic liquid
Galonde, Nadine ULg; Brostaux, Yves ULg; Richard, Gaetan ULg et al

in Process Biochemistry (2013), 48(11), 1914-1920

The purpose of the present study is to find the conditions allowing to reach the highest 24 h-yield(24 h- ) for the synthesis of mannosyl myristate catalyzed by the immobilized lipase B from Candida ... [more ▼]

The purpose of the present study is to find the conditions allowing to reach the highest 24 h-yield(24 h- ) for the synthesis of mannosyl myristate catalyzed by the immobilized lipase B from Candida antarctica (Novozym®435) in the ionic liquid (IL) [Bmpyrr][TFO] (1-butyl-1-methylpyrrolidinium tri-fluoromethanesulfonate). A full factorial design (FFD) was used in order to study the influence of three variables (temperature, mannose/vinyl myristate ratio and total substrate quantity) on the 24 h- . This design led to a model based on a second order polynomial response function. The resulting predicted con-tour plots have shown that the highest 24 h- should be obtained with high temperatures, low sugar/vinylester molar ratio and intermediate total substrate quantities (mmol). The model has been successfully verified and experimentally confirmed at the optimal conditions of 80◦C, substrate molar ratio of 1/10and total substrate quantity of 0.26 mmol leading to the highest predicted 24 h- of 72.2%. [less ▲]

Detailed reference viewed: 39 (18 ULg)
Full Text
Peer Reviewed
See detailCLINICAL AND FUNCTIONAL CHARACTERISTICS OF NONAGENARIANS HOSPITALIZED IN A GERIATRIC UNIT: A DESCRIPTIVE STUDY
Petermans, Jean ULg; Mathieu, Sandrine; ALLEPAERTS, Sophie ULg et al

in Journal of Aging Research and Clinical Practice (2013), 2(3), 303-309

Detailed reference viewed: 39 (10 ULg)
Full Text
Peer Reviewed
See detailThe Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2
Peulen, Olivier ULg; Gonzalez, Arnaud; Peixoto, Paul ULg et al

in PLoS ONE (2013), 8(9), 75102

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death worldwide, with no satisfactory treatment to date. In this study, we tested whether the combined inhibition of cyclooxygenase-2 ... [more ▼]

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death worldwide, with no satisfactory treatment to date. In this study, we tested whether the combined inhibition of cyclooxygenase-2 (COX-2) and class I histone deacetylase (HDAC) may results in a better control of pancreatic ductal adenocarcinoma. The impact of the concomitant HDAC and COX-2 inhibition on cell growth, apoptosis and cell cycle was assessed first in vitro on human pancreas BxPC-3, PANC-1 or CFPAC-1 cells treated with chemical inhibitors (SAHA, MS-275 and celecoxib) or HDAC1/2/3/7 siRNA. To test the potential antitumoral activity of this combination in vivo, we have developed and characterized, a refined chick chorioallantoic membrane tumor model that histologically and proteomically mimics human pancreatic ductal adenocarcinoma. The combination of HDAC1/3 and COX-2 inhibition significantly impaired proliferation of BxPC-3 cells in vitro and stalled entirely the BxPC-3 cells tumor growth onto the chorioallantoic membrane in vivo. The combination was more effective than either drug used alone. Consistently, we showed that both HDAC1 and HDAC3 inhibition induced the expression of COX-2 via the NF-kB pathway. Our data demonstrate, for the first time in a Pancreatic Ductal Adenocarcinoma (PDAC) model, a significant action of HDAC and COX-2 inhibitors on cancer cell growth, which sets the basis for the development of potentially effective new combinatory therapies for pancreatic ductal adenocarcinoma patients. [less ▲]

Detailed reference viewed: 34 (13 ULg)
Full Text
Peer Reviewed
See detailExperimental techniques for ballistic pressure measurements and recent development in means of calibration
Elkarous, Lamine ULg; Coghe, Frederik; Pirlot, Marc et al

in Journal of Physics: Conference Series (2013), 459

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailSéjours en dystopie, ou l’anticipation à la française. Recension de Natacha VAS-DEYRES, Ces Français qui ont écrit demain. Utopie, anticipation et science-fiction au XXe siècle
Stienon, Valérie ULg

in Acta Fabula : Revue des Parutions en Théorie Littéraire (2013), 14(6),

La science‑fiction, parce qu’elle est particulièrement centrée sur les questions sociales et les rapports sociopolitiques, serait devenue au xxe siècle le creuset des utopies. Les textes variés qui la ... [more ▼]

La science‑fiction, parce qu’elle est particulièrement centrée sur les questions sociales et les rapports sociopolitiques, serait devenue au xxe siècle le creuset des utopies. Les textes variés qui la composent, désormais axés non plus sur la description d’un idéal mais sur la confrontation au réel, épouseraient les scansions de l’Histoire dans laquelle ils sont engagés et pourraient être considérés à l’aune d’une représentation réaliste. C’est en s’appuyant sur ce double constat que Natacha Vas‑Deyres étudie la « littérature utopique » en mêlant à dessein les sous‑genres et en donnant la prédilection à son ancrage historique. [less ▲]

Detailed reference viewed: 32 (1 ULg)
Full Text
Peer Reviewed
See detailPump and probe of ultrafast charge reorganization in small peptides: A computational study through sudden ionizations
Kus, Tomasz ULg; Mignolet, Benoît ULg; Levine, R. D. et al

in Journal of Physical Chemistry A (2013), 117(40), 10513-10525

Detailed reference viewed: 13 (5 ULg)
Full Text
Peer Reviewed
See detailClassification and environmental properties of X-ray selected point-like sources in the XMM-LSS field
Melnyk, Olga ULg; Plionis, M.; Elyiv, Andrii ULg et al

in Astronomy and Astrophysics (2013), 557(A81),

Detailed reference viewed: 25 (7 ULg)
Full Text
Peer Reviewed
See detailUse of lipases for the kinetic resolution of lactic acid esters in heptane or in a solvent free system
Richard, Gaetan ULg; Nott, Katherine ULg; Nicks, François et al

in Journal of Molecular Catalysis B : Enzymatic (2013), 97

tKinetic resolution of d,l-ethyl lactate (d,l-LA-Et) and d,l-butyl lactate (d,l-LA-Bu) was accomplished inthe presence of lipases. Transesterification of the lactate esters with alcohols was shown to be ... [more ▼]

tKinetic resolution of d,l-ethyl lactate (d,l-LA-Et) and d,l-butyl lactate (d,l-LA-Bu) was accomplished inthe presence of lipases. Transesterification of the lactate esters with alcohols was shown to be poorlyenantioselective, with a very low preference toward the l enantiomer. However, esterification of the freehydroxyl function of the lactate esters was much more enantioselective, with an opposite preferencetoward the d form. Among the 200 combinations screened (substrates and lipases), only two reactionsfulfilled the required criteria for an efficient resolution (fast reaction, enantioselectivity ratio higherthan 100). The best resolution was obtained by esterification of d,l-LA-Bu with butyric anhydride inthe presence of lipase B from Candida antarctica (CAL-B) in heptane (at 30◦C): LA-Bu was resolved in6 h with an initial esterification rate of d-LA-BU of 1.5 g L−1h−1g−1EZ, an enantioselectivity ratio higherthan 100, a l substrate consumption lower than 1%, and a final substrate enantiomeric excess superiorto 99%. After having demonstrated that neither LA-Bu nor BuAn were inhibitors of CAL-B, the reactionwas further improved by carrying it out in a solvent free system, at an elevated temperature (60◦C), andat a higher lipase concentration. LA-Bu was resolved in 6 h with an initial rate of 7.6 g L−1h−1g−1EZ, anenantioselectivity ratio higher than 100, and a final substrate enantiomeric excess of 95%. [less ▲]

Detailed reference viewed: 30 (18 ULg)
Full Text
Peer Reviewed
See detailDiversity and endemism of Murinae rodents in Thai limestone karsts
Latinne, Alice ULg; Waengsothorn, Surachit; Rojanadilok, Prateep et al

in Systematics and Biodiversity (2013), 11(3), 323-344

This study aims to investigate the species diversity of rodents living in karst ecosystems of Thailand. A survey has been conducted throughout Thailand, 122 karsts sampled and 477 Murinae rodents live ... [more ▼]

This study aims to investigate the species diversity of rodents living in karst ecosystems of Thailand. A survey has been conducted throughout Thailand, 122 karsts sampled and 477 Murinae rodents live-trapped. Phylogenetic reconstructions were carried out using two mitochondrial markers (cytb, COI). A sequence-based species delimitation method completed by the analysis of the level of genetic divergence was then applied to define species boundaries within our dataset. The phylogenetic position of Niviventer hinpoon was also investigated and sequences obtained from the holotype specimen of this species were used to reliably identify samples of N. hinpoon. A total of 12 described Murinae species, corresponding to 17 deeply divergent genetic lineages, were encountered in limestone karsts of Thailand. Our study revealed an important genetic diversity within the traditionally recognized species Maxomys surifer (four highly divergent genetic lineages), Leopoldamys neilli (two highly divergent genetic lineages) and Berylmys bowersi (two highly divergent genetic lineages). These species could be considered as species complex and require further taxonomic work. This study also provides valuable information on the distribution of the two rodent species endemic to limestone karsts of Thailand, L. neilli and N. hinpoon. Leopoldamys neilli was the most abundant species encountered in Thai karsts during our survey. However, L. neilli specimens from western Thailand are genetically highly divergent from the remaining populations of L. neilli and could represent a separate species. Niviventer hinpoon, phylogenetically closely related to N. fulvescens, is much rarer and its distribution limited to central Thailand. Most of the other captured species are typically associated with forest ecosystems. This study suggests that limestone karsts play a key role in the preservation of the rodent species endemic to such habitat, but they would also provide refuges for the forest-dwelling Murinae rodents in deforested regions. [less ▲]

Detailed reference viewed: 37 (4 ULg)
Full Text
Peer Reviewed
See detailL’envoi par Taxipost secur et l’exigence d’un courrier recommandé à la poste en droit du travail
Coenegrachts, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2013), 2

Detailed reference viewed: 16 (3 ULg)
Full Text
Peer Reviewed
See detailAn analysis on energy efficiency initiatives in the building stock of Liege, Belgium
Singh, Manoj Kumar ULg; Mahapatra, Sadhan; Teller, Jacques ULg

in Energy Policy (2013), http://dx.doi.org/10.1016/j.enpol.2013.07.138

Built environment is responsible for 60% of total energy consumption in European countries and 128 million BOE of primary energy in Belgium. The average energy consumption in the residential buildings of ... [more ▼]

Built environment is responsible for 60% of total energy consumption in European countries and 128 million BOE of primary energy in Belgium. The average energy consumption in the residential buildings of Belgium is 70% higher than the EU average and stands at 348 kWh/m2/year. Energy Performance Building Directive (EPBD) provides guidelines for energy performance analysis of buildings in Belgium. In this study, a holistic approach has been adopted to analyse the building stock of Liege, Belgium. This analysis is based on ‘General Socio-economic survey 2001’ and ‘Housing quality survey 2006 in Walloon region’databases. It considers parameters such as buildings age, built-up area, type of heating system, type of fuel used, adjacency, insulation of roofs and walls and energy consumption etc. for an in depth analysis. This study concludes that about 69% of buildings which are constructed before 1945 needs serious renovation towards the improvement of roof and external wall insulation level. It then successfully identifies specific areas which need detailed study to evaluate the comfort status in the existing building stock, improvement of insulation level and its effect on heating energy consumption as well as the economic analysis on energy efficiency measurements. [less ▲]

Detailed reference viewed: 25 (6 ULg)
Full Text
Peer Reviewed
See detailEvading death by vacuum
Barroso, Augusto; Ferreira, Pedro; Ivanov, Igor ULg et al

in European Physical Journal C -- Particles & Fields (2013), 73

In the Standard Model, the Higgs potential allows only one minimum at tree level. But the open possibility that there might be two scalar doublets enriches the vacuum structure, allowing for the risk that ... [more ▼]

In the Standard Model, the Higgs potential allows only one minimum at tree level. But the open possibility that there might be two scalar doublets enriches the vacuum structure, allowing for the risk that we might now be in a metastable state, which we dub the panic vacuum. Current experiments at the LHC are probing the Higgs particle predicted as a result of the spontaneous symmetry breaking. Remarkably, in the two Higgs model with a softly broken U(1) symmetry, the LHC experiments already allow to exclude many panic vacuum solutions. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailDiscovery of a magnetic field in the CoRoT hybrid B-type pulsator HD 43317
Briquet, Maryline ULg; Neiner, C.; Leroy, B. et al

in Astronomy and Astrophysics (2013), 557

Context. A promising way of testing the impact of a magnetic field on internal mixing (core overshooting, internal rotation) in main-sequence B-type stars is to perform asteroseismic studies of a sample ... [more ▼]

Context. A promising way of testing the impact of a magnetic field on internal mixing (core overshooting, internal rotation) in main-sequence B-type stars is to perform asteroseismic studies of a sample of magnetic pulsators. <BR /> Aims: The CoRoT satellite revealed that the B3IV star HD 43317 is a hybrid SPB/β Cep-type pulsator that has a wealth of pulsational constraints on which one can perform a seismic modelling, in particular, probing the extent of its convective core and mixing processes. Moreover, indirect indicators of a magnetic field in the star were observed: rotational modulation due to chemical or temperature spots and X-ray emission. Our goal was to directly investigate the field in HD 43317 and, if it is magnetic, to characterise it. <BR /> Methods: We collected data with the Narval spectropolarimeter installed at Télescope Bernard Lyot (TBL, Pic du Midi, France) and applied the least-squares deconvolution technique to measure the circular polarisation of the light emitted from HD 43317. We modelled the longitudinal field measurements directly with a dipole. <BR /> Results: Zeeman signatures in the Stokes V profiles of HD 43317 are clearly detected and rotationally modulated, which proves that this star exhibits an oblique magnetic field. The modulation with the rotation period deduced from the CoRoT light curve is also confirmed, and we found a field strength at the poles of about 1 kG. Our result must be taken into account in future seismic modelling work of this star. Based on observations obtained using the Narval spectropolarimeter at the Observatoire du Pic du Midi (France), which is operated by the Institut National des Sciences de l'Univers (INSU). [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailAtmospheric parameters of 169 F-, G-, K- and M-type stars in the Kepler field
Molenda-Żakowicz, J.; Sousa, S. G.; Frasca, A. et al

in Monthly Notices of the Royal Astronomical Society (2013), 434

The asteroseismic and planetary studies, like all research related to stars, need precise and accurate stellar atmospheric parameters as input. We aim at deriving the effective temperature (T[SUB]eff[/SUB ... [more ▼]

The asteroseismic and planetary studies, like all research related to stars, need precise and accurate stellar atmospheric parameters as input. We aim at deriving the effective temperature (T[SUB]eff[/SUB]), the surface gravity (log g), the metallicity ([Fe/H]), the projected rotational velocity (v sin i) and the MK type for 169 F-, G-, K- and M-type Kepler targets which were observed spectroscopically from the ground with five different instruments. We use two different spectroscopic methods to analyse 189 high-resolution, high-signal-to-noise spectra acquired for the 169 stars. For 67 stars, the spectroscopic atmospheric parameters are derived for the first time. KIC 9693187 and 11179629 are discovered to be double-lined spectroscopic binary systems. The results obtained for those stars for which independent determinations of the atmospheric parameters are available in the literature are used for a comparative analysis. As a result, we show that for solar-type stars the accuracy of present determinations of atmospheric parameters is ±150 K in T[SUB]eff[/SUB], ±0.15 dex in [Fe/H] and ±0.3 dex in log g. Finally, we confirm that the curve-of-growth analysis and the method of spectral synthesis yield systematically different atmospheric parameters when they are applied to stars hotter than 6000 K. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailA detailed census of variable stars in the globular cluster NGC 6333 (M9) from CCD differential photometry
Arellano Ferro, A.; Bramich, D. M.; Figuera Jaimes, R. et al

in Monthly Notices of the Royal Astronomical Society (2013), 434

We report CCD V and I time series photometry of the globular cluster NGC 6333 (M9). The technique of difference image analysis has been used, which enables photometric precision better than 0.05 mag for ... [more ▼]

We report CCD V and I time series photometry of the globular cluster NGC 6333 (M9). The technique of difference image analysis has been used, which enables photometric precision better than 0.05 mag for stars brighter than V ˜ 19.0 mag, even in the crowded central regions of the cluster. The high photometric precision has resulted in the discovery of two new RRc stars, three eclipsing binaries, seven long-term variables and one field RRab star behind the cluster. A detailed identification chart and equatorial coordinates are given for all the variable stars in the field of our images of the cluster. Our data together with the literature V-data obtained in 1994 and 1995 allowed us to refine considerably the periods for all RR Lyrae stars. The nature of the new variables is discussed. We argue that variable V12 is a cluster member and an Anomalous Cepheid. Secular period variations, double-mode pulsations and/or the Blazhko-like modulations in some RRc variables are addressed. Through the light-curve Fourier decomposition of 12 RR Lyrae stars we have calculated a mean metallicity of [Fe/H][SUB]ZW[/SUB] = -1.70 ± 0.01(statistical) ± 0.14(systematic) or [Fe/H]_{text{UVES}}=-1.67 ± 0.01(statistical) ± 0.19(systematic). Absolute magnitudes, radii and masses are also estimated for the RR Lyrae stars. A detailed search for SX Phe stars in the Blue Straggler region was conducted but none were discovered. If SX Phe exist in the cluster then their amplitudes must be smaller than the detection limit of our photometry. The colour-magnitude diagram has been corrected for heavy differential reddening using the detailed extinction map of the cluster of Alonso-García et al. This has allowed us to set the mean cluster distance from two independent estimates; from the RRab and RRc absolute magnitudes, we find 8.04 ± 0.19 and 7.88 ± 0.30 kpc, respectively. [less ▲]

Detailed reference viewed: 19 (12 ULg)
Full Text
Peer Reviewed
See detailA Herschel Study of D/H in Water in the Jupiter-family Comet 45P/Honda-Mrkos-Pajdušáková and Prospects for D/H Measurements with CCAT
Lis, D. C.; Biver, N.; Bockelée-Morvan, D. et al

in Astrophysical Journal Letters (2013), 774

We present Herschel observations of water isotopologues in the atmosphere of the Jupiter-family comet 45P/Honda-Mrkos-Pajdušáková. No HDO emission is detected, with a 3σ upper limit of 2.0 × 10[SUP]–4 ... [more ▼]

We present Herschel observations of water isotopologues in the atmosphere of the Jupiter-family comet 45P/Honda-Mrkos-Pajdušáková. No HDO emission is detected, with a 3σ upper limit of 2.0 × 10[SUP]–4[/SUP] for the D/H ratio. This value is consistent with the earlier Herschel measurement in the Jupiter-family comet 103P/Hartley 2. The canonical value of 3 × 10[SUP]–4[/SUP] measured pre-Herschel in a sample of Oort-cloud comets can be excluded at a 4.5σ level. The observations presented here further confirm that a diversity of D/H ratios exists in the comet population and emphasize the need for additional measurements with future ground-based facilities, such as CCAT, in the post-Herschel era. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailComets C/2012 V2 (LINEAR) and C/2013 R1 (Lovejoy)
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Central Bureau Electronic Telegrams (2013), 3659

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailImpact des périodes d'attente et de reproduction sur la fécondité de la vache laitière
Chapaux, Philippe; Glorieux, Géry; Hanzen, Christian ULg

in Wallonie Elevages (2013)

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailLow-amplitude rotational modulation rather than pulsations in the CoRoT B-type supergiant HD 46769
Aerts, C.; Simón-Díaz, S.; Catala, C. et al

in Astronomy and Astrophysics (2013), 557

<BR /> Aims: We aim to detect and interpret photometric and spectroscopic variability of the bright CoRoT B-type supergiant target HD 46769 (V = 5.79). We also attempt to detect a magnetic field in the ... [more ▼]

<BR /> Aims: We aim to detect and interpret photometric and spectroscopic variability of the bright CoRoT B-type supergiant target HD 46769 (V = 5.79). We also attempt to detect a magnetic field in the target. <BR /> Methods: We analyse a 23-day oversampled CoRoT light curve after detrending and spectroscopic follow-up data using standard Fourier analysis and phase dispersion minimization methods. We determine the fundamental parameters of the star, as well as its abundances from the most prominent spectral lines. We perform a Monte Carlo analysis of spectropolarimetric data to obtain an upper limit of the polar magnetic field, assuming a dipole field. <BR /> Results: In the CoRoT data, we detect a dominant period of 4.84 d with an amplitude of 87 ppm and some of its (sub-)multiples. Given the shape of the phase-folded light curve and the absence of binary motion, we interpret the dominant variability in terms of rotational modulation, with a rotation period of 9.69 d. Subtraction of the rotational modulation signal does not reveal any sign of pulsations. Our results are consistent with the absence of variability in the Hipparcos light curve. The spectroscopy leads to a projected rotational velocity of 72 ± 2 km s[SUP]-1[/SUP] and does not reveal periodic variability or the need to invoke macroturbulent line broadening. No signature of a magnetic field is detected in our data. A field stronger than ~500 G at the poles can be excluded, unless the possible non-detected field were more complex than dipolar. <BR /> Conclusions: The absence of pulsations and macroturbulence of this evolved B-type supergiant is placed into the context of instability computations and of observed variability of evolved B-type stars. Based on CoRoT space-based photometric data; the CoRoT space mission was developed and operated by the French space agency CNES, with the participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain. Based on observations collected at La Silla Observatory, ESO (Chile) with the HARPS spectrograph at the 3.6 m telescope, under programme LP185.D-0056. Based on observations obtained with the HERMES spectrograph attached to the 1.2 m Mercator telescope, which is supported by the Fund for Scientific Research of Flanders (FWO), Belgium, the Research Council of KU Leuven, Belgium, the Fonds National de la Recherche Scientific (FNRS), Belgium, the Royal Observatory of Belgium, the Observatoire de Genève, Switzerland, and the Thüringer Landessternwarte Tautenburg, Germany. Based on observations obtained with the Narval spectropolarimeter at the Observatoire du Pic du Midi (France), which is operated by the Institut National des Sciences de l'Univers (INSU). [less ▲]

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailHigh-precision photometry by telescope defocusing - V. WASP-15 and WASP-16
Southworth, John; Mancini, L.; Browne, P. et al

in Monthly Notices of the Royal Astronomical Society (2013), 434

We present new photometric observations of WASP-15 and WASP-16, two transiting extrasolar planetary systems with measured orbital obliquities but without photometric follow-up since their discovery papers ... [more ▼]

We present new photometric observations of WASP-15 and WASP-16, two transiting extrasolar planetary systems with measured orbital obliquities but without photometric follow-up since their discovery papers. Our new data for WASP-15 comprise observations of one transit simultaneously in four optical passbands using GROND on the MPG/European Southern Observatory (ESO) 2.2 m telescope, plus coverage of half a transit from DFOSC on the Danish 1.54 m telescope, both at ESO La Silla. For WASP-16 we present observations of four complete transits, all from the Danish telescope. We use these new data to refine the measured physical properties and orbital ephemerides of the two systems. Whilst our results are close to the originally determined values for WASP-15, we find that the star and planet in the WASP-16 system are both larger and less massive than previously thought. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailCharacterization of clay deposits of Nanga-Eboko (Central Cameroon): Suitability in the production of building materials
Nzeukou Nzeugang, A.; Medjo Eko, R.; Fagel, Nathalie ULg et al

in Clay Minerals (2013), 48(4), 655-662

Detailed reference viewed: 23 (8 ULg)
Full Text
Peer Reviewed
See detailCOSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses: XIV. Time delay of the doubly lensed quasar SDSS~J1001+5027
Rathna Kumar, S.; Tewes, M.; Stalin, C.S. et al

in Astronomy and Astrophysics (2013), 557

This paper presents optical R-band light curves and the time delay of the doubly imaged gravitationally lensed quasar SDSS J1001+5027 at a redshift of 1.838. We have observed this target for more than six ... [more ▼]

This paper presents optical R-band light curves and the time delay of the doubly imaged gravitationally lensed quasar SDSS J1001+5027 at a redshift of 1.838. We have observed this target for more than six years, between March 2005 and July 2011, using the 1.2-m Mercator Telescope, the 1.5-m telescope of the Maidanak Observatory and the 2-m Himalayan Chandra Telescope. Our resulting light curves are composed of 443 independent epochs, and show strong intrinsic quasar variability, with an amplitude of the order of 0.2 magnitudes. From this data, we measure the time delay using five different methods, all relying on distinct approaches. One of these techniques is a new development presented in this paper. All our time-delay measurements are perfectly compatible. By combining them, we conclude that image A is leading B by 119.3 ± 3.3 days (1σ, 2.8%), including systematic errors. It has been shown recently that such accurate time-delay measurements offer a highly complementary probe of dark energy and spatial curvature, as they independently constrain the Hubble constant. The next mandatory step towards using SDSS J1001+5027 in this context will be the measurement of the redshift of the lensing galaxy, in combination with deep HST imaging. [less ▲]

Detailed reference viewed: 3 (2 ULg)
Full Text
Peer Reviewed
See detailComparative analysis of airglow emissions in terrestrial planets, observed with VIRTIS-M instruments on board Rosetta and Venus Express
Migliorini, A.; Piccioni, G.; Capaccioni, F. et al

in Icarus (2013), 226

Airglow emissions are optimal processes to investigate the chemistry and dynamics in planetary atmospheres. In this study, we focus on the O2 and OH airglow emissions in Venus, Earth, and Mars atmospheres ... [more ▼]

Airglow emissions are optimal processes to investigate the chemistry and dynamics in planetary atmospheres. In this study, we focus on the O2 and OH airglow emissions in Venus, Earth, and Mars atmospheres, which are controlled by chemical reactions common to the three planets. By studying these phenomena on Venus, Earth, and Mars using similar instruments, we are able to derive information about their photochemistry and the physical conditions of the atmospheres, but also to constrain the dynamics responsible for transport of atomic oxygen, ozone and other minor species. After a review of the nightglow emissions observed in the Venus atmosphere, we analyze the O2 and OH airglow emissions in the Earth's atmosphere observed during the 3 swing-bys of our planet by the Rosetta spacecraft. We also report the detection of the O2 nightglow emission in the Mars atmosphere, observed in February 2007 during the Rosetta fly-by of the planet. The airglow characteristics are in agreement with the measurements obtained from sensors on board Mars Express. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailA two-scale model predicting the mechanical behavior of nanocrystalline solids
Péron-Lührs, Vincent ULg; Jérusalem, Antoine; Sansoz, Frédéric et al

in Journal of the Mechanics & Physics of Solids (2013), 61(9), 1895-1914

Polycrystalline materials, with nanosized grains (<100 nm), exhibit superior strength exceeding those of their coarse-grained counterparts. With such small grains, the deformation mechanisms taking place ... [more ▼]

Polycrystalline materials, with nanosized grains (<100 nm), exhibit superior strength exceeding those of their coarse-grained counterparts. With such small grains, the deformation mechanisms taking place at grain boundaries (GBs) become dominant compared to the intragranular crystal plasticity. Recent studies have revealed that the deformation mechanisms are influenced by the GB network. For instance, a high yield stress in nanostructured metals can be obtained by choosing the relevant grain boundary character distribution (GBCD). In this paper we present an original numerical multiscale approach to predict the mechanical behavior of nanostructured metals according to their GBCD composed of either high angle (HA) GBs (HAB) or low angle (LA) GBs (LAB). Molecular simulations using the quasicontinuum method (QC) are performed to obtain the mechanical response at the nanoscale of GB undergoing simple shear (GB sliding behavior) and tensile loads (GB opening behavior). To simulate the grain behavior, a mechanical model of dislocation motions through a forest dislocation is calibrated using a nanoindentation simulation performed with QC. These QC results are then used in a finite element code (direct numerical simulation-DNS) as a GB constitutive model and as a grain constitutive model. This two-scale framework does not suffer from length scale limitations conventionally encountered when considering the two scales separately. [less ▲]

Detailed reference viewed: 99 (27 ULg)
Full Text
Peer Reviewed
See detailLa production des campagnes médiatiques de santé publique : une dialectique entre normalisation des comportements collectifs et appel à la responsabilisation individuelle
Ketterer, Frédéric ULg

in Socio-Logos (2013), 8

Since the seventies, communication campaigns in public health have become systematic. Today they are considered as full political actions. We analyzed their production based on data of three monographs of ... [more ▼]

Since the seventies, communication campaigns in public health have become systematic. Today they are considered as full political actions. We analyzed their production based on data of three monographs of French campaigns – two concerning mental health and a third one on AIDS. This analysis highlighted the existence of an interweaving of collective and individual dimensions of the considered health facts. The collective dimension appeared through the "social construction of public health" (Fassin, 2005). It comprises a phase of medicalization of social facts (transcription of a pathology in the social language), and another of giving a political dimension to it, which implies multiplying the actors linked to the topic. Both phases require the demonstration of the collective nature of the disease, using ad hoc tools - epidemiology, economic consequences, etc. However the production process of these campaigns is then marked by a shift to the individual dimension of health behaviours. How one considers communication reflects the current governmentality. Delivered messages attempt to empower targets in adapting their behaviour. This individual responsibility hides then the existence of risk groups; the social determinants of behaviours give way to the psychologising of social that reduces behaviour to the only individual responsibility. The produced media messages will then try to avoid associating a disease to a particular group, in order to reach as many people as possible, but also not to blame or stigmatize a particular part of the population. Therefore, inspired by the collective dimension of disease, public health messages, however, choose individual media process of health behaviours. [less ▲]

Detailed reference viewed: 17 (5 ULg)
Full Text
Peer Reviewed
See detailContribution of land use changes to future flood damage along the river Meuse in the Walloon region
Beckers, Arnaud ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Natural Hazards & Earth System Sciences (2013), 13

Managing flood risk in Europe is a critical issue because climate change is expected to increase flood hazard in many european countries. Beside climate change, land use evolution is also a key factor ... [more ▼]

Managing flood risk in Europe is a critical issue because climate change is expected to increase flood hazard in many european countries. Beside climate change, land use evolution is also a key factor influencing future flood risk. The core contribution of this paper is a new methodology to model residential land use evolution. Based on two climate scenarios (“dry” and “wet”), the method is applied to study the evolution of flood damage by 2100 along the river Meuse. Nine urbanization scenarios were developed: three of them assume a “current trend” land use evolution, leading to a significant urban sprawl, while six others assume a dense urban development, characterized by a higher density and a higher diversity of urban functions in the urbanized areas. Using damage curves, the damage estimation was performed by combining inundation maps for the present and future 100 yr flood with present and future land use maps and specific prices. According to the dry scenario, the flood discharge is expected not to increase. In this case, land use changes increase flood damages by 1–40 %, to EUR 334–462 million in 2100. In the wet scenario, the relative increase in flood damage is 540–630 %, corresponding to total damages of EUR 2.1–2.4 billion. In this extreme scenario, the influence of climate on the overall damage is 3–8 times higher than the effect of land use change. However, for seven municipalities along the river Meuse, these two factors have a comparable influence. Consequently, in the “wet” scenario and at the level of the whole Meuse valley in the Walloon region, careful spatial planning would reduce the increase in flood damage by no more than 11–23 %; but, at the level of several municipalities, more sustainable spatial planning would reduce future flood damage to a much greater degree. [less ▲]

Detailed reference viewed: 107 (37 ULg)
Full Text
Peer Reviewed
See detailPSDC et prise de risque : telle est la question
Dumoulin, André ULg

in revue de défense nationale (2013), (3),

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailCharacterization of clay deposits of Nanga-Eboko (Central Cameroon): Suitability in the production of building materials
Mache, Jacques Richard ULg

in Clay Minerals (2013), 48

Clayey deposits of Nanga-Eboko (Central Cameroon) were studied to assess their potential as building materials. Characterization was performed using XRD, IR, XRF, DTA/DTG and firing. Clays appear as ... [more ▼]

Clayey deposits of Nanga-Eboko (Central Cameroon) were studied to assess their potential as building materials. Characterization was performed using XRD, IR, XRF, DTA/DTG and firing. Clays appear as discontinuous pockets with the same organizational characteristics in three villages located on both sides of the Sanaga River. The average thickness of exploitable layer is about 3m. The estimated tonnage ~7-17x105 m3 can supply an industry of great importance. SiO2 (~70%), Al2O3 (~15%) and Fe2O3 (~4%) are the predominant oxides of the natural clays. Quartz (~55%), kaolinite (~33%), illite (~5%) and K-feldspar (~4%) are major minerals. Clays are not suitable for building construction due to their fine-grained size and high plasticity properties. Firing properties of bricks (950 and 1050°C) are good despite the high shrinkage values. Therefore the addition of "degreasers' is recommended to control shaping and drying. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailEfficiency of inventory plot patterns in quantitative analysis of vegetation : a case study of tropical woodland and dense forest in Benin
Salako, Valère K.; Glele Kakai, Romain L.; Assogbadjo, Achille E. et al

in Southern Forests : a Journal of Forest Science (2013), 75(3), 137-143

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailLa fratrie face au "coming-out"
Haxhe, Stéphanie ULg; D'Amore, Salvatore ULg

in Thérapie Familiale (2013), 34(2), 215-230

Detailed reference viewed: 39 (9 ULg)
Full Text
Peer Reviewed
See detailL’insuffisance mitrale chez le cheval : revue de la littérature et comparaison avec la pathologie chez l’homme et chez le chien
Al Haidar, Ali; Leroux, Aurélia ULg; Amory, Hélène ULg

in Annales de Médecine Vétérinaire (2013), 157(1), 52-68

Abstract Mitral regurgitation (MR) is a one of the most common cardiac disease in the equine species. Furthermore, it is the valvular disease that presents the higher risk to be associated with reduced ... [more ▼]

Abstract Mitral regurgitation (MR) is a one of the most common cardiac disease in the equine species. Furthermore, it is the valvular disease that presents the higher risk to be associated with reduced athletic performance, to evolve into congestive heart failure and to become life threatening. The clinical diagnosis of MR depends mainly on the expertise of the veterinarian in cardiology and is above all based on cardiac auscultation. In all of the cases, the definitive diagnosis and the evaluation of the disease severity require performing a Doppler echocardiographic examination. Signs of left ventricular and/or left atrial overload, large regurgitation jet, pulmonary arterial hypertension or significant arrhythmias are negative prognosis factors. Clinical signs of congestive heart failure make the prognosis worse. Other echocardiographic parameters are used in human and dogs in order to determine the severity of the MR, but have been not validated in horses. Treatment of mitral regurgitation in the equine species is symptomatic and directed against the development of a congestive heart failure. A lot of drugs that are used in human or dogs are of limited value in horses for financial reasons and/or lack of pharmacokinetics and pharmacologic data in equine species. [less ▲]

Detailed reference viewed: 51 (24 ULg)
Full Text
Peer Reviewed
See detailGéographies religieuses et migrations postcoloniales: déclinaisons kimbanguistes, pentecôtistes, olangistes en Belgique
Demart, Sarah ULg; Meiers, Bénédicte ULg; Melice, Anne ULg

in African Diaspora : a Journal of Transnational Africa in a Global World (2013), 6(1), 122-149

Detailed reference viewed: 49 (6 ULg)
Full Text
Peer Reviewed
See detailProposal of a simplified analytical approach for the characterisation of the end-plate component in circular tube connection
Hoang, Van Long ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (2013), 90

This paper presents a study realised at Liège University on the behaviour of the rectangular end-plate in bending and the bolt in tension components met in circular tube-to- circular tube connections and ... [more ▼]

This paper presents a study realised at Liège University on the behaviour of the rectangular end-plate in bending and the bolt in tension components met in circular tube-to- circular tube connections and in circular tubular column bases. Analytical formulas for the mentioned components are firstly proposed considering different yield line patterns for the end-plate. Then the results predicted through the proposed analytical approach are validated through comparisons to experimental and finite element results. Finally, the application of the proposed approach for the prediction of the strength of tube-to-tube joints and also for the prediction of the bolt force of column bases is demonstrated. [less ▲]

Detailed reference viewed: 29 (8 ULg)
Full Text
Peer Reviewed
See detailGiulio Massimilla (ed.), Callimaco, Aitia. Libro terzo e quarto, «Biblioteca di studi antichi» 92, Pisa/Roma, Fabrizio Serra editore, 2010.
Caneva, Stefano ULg

in Athenaeum : Studii Periodici di Letteratura e Storia (2013), 101.I-II

Detailed reference viewed: 118 (3 ULg)
Full Text
Peer Reviewed
See detailImpact of sensor and measurement timing errors on model-based insulin sensitivity
Pretty, Christopher ULg; Signal, Matthew; Fisk, Liam et al

in Computer Methods & Programs in Biomedicine (2013)

Detailed reference viewed: 13 (0 ULg)
Full Text
See detailActualités et perspectives du warrant
Vrancken, Martin ULg

in Revue de la Faculté de Droit de l'Université de Liège (2013), (2), 185-235

Le présent entend présenter la figure du warrant dans le paysage des sûretés réelles mobilières en droit belge. Il tient compte de la récente réforme du régime des sûretés réelles mobilières, survenue en ... [more ▼]

Le présent entend présenter la figure du warrant dans le paysage des sûretés réelles mobilières en droit belge. Il tient compte de la récente réforme du régime des sûretés réelles mobilières, survenue en 2013. [less ▲]

Detailed reference viewed: 34 (11 ULg)
Full Text
Peer Reviewed
See detailNew 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting.
Mathieu, Véronique; Van Den Brege, E; Ceusters, Justine ULg et al

in Journal of Medicinal Chemistry (2013), 56(17), 6626-6637

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailResponse of Black African patients with hepatitis C virus genotype 4 to treatment with peg-interferon and ribavirin
Nkuize, M; Mulkay, JP; Adler, M et al

in Acta Gastro-Enterologica Belgica (2013), 76

Aim : To compare responses to therapy of Black African (BA) and non-Black African (non- BA) patients with hepatitis C virus genotype 4 (HCV-4) residing in Belgium. Methods : In this retrospective ... [more ▼]

Aim : To compare responses to therapy of Black African (BA) and non-Black African (non- BA) patients with hepatitis C virus genotype 4 (HCV-4) residing in Belgium. Methods : In this retrospective multicenter study, 473 patients with HCV-4 were selected from databases at 7 Belgian centers ; 209 treatment-naïve patients (154 BA) had received treatment with peg-interferon (peg-IFN) plus ribavirin (RBV) and were included in the study. Results : There was a greater percentage of female patients in the BA group than in the non- BA group ; BA patients were also older, had a greater body mass index, and more frequently had abnormal glucose metabolism. The route of contamination was more frequently unknown in BA than in non-BA patients and BA patients had more HCV-4 subtypes. There were no differences in other demographic factors between the groups. Sustained viral response (SVR) and complete early viral response rates were significantly lower and relapse rates significantly higher in BA than in non-BA patients. There were no differences between groups in rates of dose modification or in drug tolerance. Conclusion : In our cohort, treatment-naïve BA patients with HCV-4 who were treated with peg-IFN and ribavirin had a much lower SVR rate than treatment-naïve non-BA patients with HCV- 4 who were treated with peg-IFN and ribavirin, and a higher relapse rate, possibly related to a weaker response to interferonbased therapy. Treatment may need to be adapted in this population. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
See detailLa dynastie belge et la science d’Albert Ier à la Commission nationale des sciences (1909-1959)
Pirot, Pascal ULg

in Bulletin d’information de l’Association belge d’histoire contemporaine (2013)

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailProteomic Investigation of Aphid Honeydew Reveals an Unexpected Diversity of Proteins
Sabri, Ahmed; Vandermoten, Sophie ULg; Leroy, Pascal et al

in PLoS ONE (2013), 8(9),

Aphids feed on the phloem sap of plants, and are the most common honeydew-producing insects. While aphid honeydew is primarily considered to comprise sugars and amino acids, its protein diversity has yet ... [more ▼]

Aphids feed on the phloem sap of plants, and are the most common honeydew-producing insects. While aphid honeydew is primarily considered to comprise sugars and amino acids, its protein diversity has yet to be documented. Here, we report on the investigation of the honeydew proteome from the pea aphid Acyrthosiphon pisum. Using a two-Dimensional Differential in-Gel Electrophoresis (2D-Dige) approach, more than 140 spots were isolated, demonstrating that aphid honeydew also represents a diverse source of proteins. About 66% of the isolated spots were identified through mass spectrometry analysis, revealing that the protein diversity of aphid honeydew originates from several organisms (i.e. the host aphid and its microbiota, including endosymbiotic bacteria and gut flora). Interestingly, our experiments also allowed to identify some proteins like chaperonin, GroEL and Dnak chaperones, elongation factor Tu (EF-Tu), and flagellin that might act as mediators in the plant-aphid interaction. In addition to providing the first aphid honeydew proteome analysis, we propose to reconsider the importance of this substance, mainly acknowledged to be a waste product, from the aphid ecology perspective. [less ▲]

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailThe susceptibility of the knee extensors to eccentric exercise-induced muscle damage is not affected by leg dominance but by exercise order .
Hody, Stéphanie ULg; Rogister, Bernard ULg; Leprince, Pierre ULg et al

in Clinical Physiology & Functional Imaging (2013), 33(5), 373-380

The aims of this study were first to compare the response of dominant and non-dominant legs to eccentric exercise and second, to examine whether there is an effect of exercise order on the magnitude of ... [more ▼]

The aims of this study were first to compare the response of dominant and non-dominant legs to eccentric exercise and second, to examine whether there is an effect of exercise order on the magnitude of symptoms associated with intense eccentric protocols. Eighteen young men performed 3 sets of 30 maximal eccentric isokinetic (60°.sec-1) contractions of the knee extensors (range of motion, ROM: 0°-100°, 0=full extension) using either dominant or nondominant leg. They repeated a similar eccentric bout using the contralateral leg six weeks later. The sequence of leg’s use was allocated to create equally balanced groups. Four indirect markers of muscle damage including subjective pain intensity, maximal isometric strength, muscle stiffness and plasma CK activity were measured before and 24 hours after exercise. All markers changed significantly following the eccentric bout performed either by dominant or non-dominant legs but no significant difference was observed between legs. Interestingly, the comparison between the first and second eccentric bouts revealed that muscle soreness (-42%, p<0.001), CK activity (-62%, p<0.05) and strength loss (-54%, p<0.01) were significantly lower after the second bout. This study suggests that leg dominance does not influence the magnitude of exercise-induced muscle damage and supports for the first time the existence of a contralateral protection against exercise-induced muscle damage in the lower limbs. [less ▲]

Detailed reference viewed: 45 (13 ULg)
Full Text
Peer Reviewed
See detailPerformance assessment of the FAO AquaCrop model for irrigated cabbage on farmer plots in a semi-arid environment
Wellens, Joost; Raes, Dirk; Traore, Farid et al

in Agricultural Water Management (2013), 127

Small-scale irrigation initiatives are expanding rapidly in Burkina Faso. However, in many cases optimal yields are not being obtained despite the available water and the required nutrient applications ... [more ▼]

Small-scale irrigation initiatives are expanding rapidly in Burkina Faso. However, in many cases optimal yields are not being obtained despite the available water and the required nutrient applications. Local stakeholders need an easy-to-use decision-support tool to assess irrigation water use and its impact on yield. In this study, a water-driven crop model, AquaCrop, developed by FAO, was adapted for cabbage (Brassica oleracea L.) using a limited dataset and leave-one-out cross-validation (LOOCV). The experiment was conducted in south-western Burkina Faso on small irrigated farmer plots, where optimal managerial conditions could not always be guaranteed. Statistical indicators – normalized root mean square error (nRMSE) and index of agreement (d) – suggested that the model is very reliable for simulating cabbage biomass yield and soil water content (low nRMSE and d-index near 1). The relationship between observed and simulated yield produced a d-index of 0.99 and an nRMSE of 1.39% (or 0.59 ton/ha). The comparison between observed and modeled soil water content gave a d-index of 0.90 and an nRMSE of 4.38% (or 9.13 mm). Also of interest was the indirect link between plant density and yield via maximum canopy cover, which can considerably simplify yield estimation. It was concluded that AquaCrop was a very useful tool for enabling local end-users to evaluate and optimize cabbage yield and irrigation water use. [less ▲]

Detailed reference viewed: 61 (21 ULg)
Full Text
Peer Reviewed
See detailBatch mode reinforcement learning based on the synthesis of artificial trajectories
Fonteneau, Raphaël ULg; Murphy, Susan A.; Wehenkel, Louis ULg et al

in Annals of Operations Research (2013), 208(1), 383-416

Detailed reference viewed: 21 (11 ULg)
Full Text
See detail28th CHICAGO GOSPEL MUSIC FESTIVAL
Sacré, Robert ULg

in Blues & Rhythm - The Gospel Truth (2013), (282),

Detailed reference viewed: 1 (0 ULg)
Full Text
See detailBlues on the Fox 2013
Sacré, Robert ULg

in Blues & Rhythm - The Gospel Truth (2013), (282),

Detailed reference viewed: 5 (2 ULg)
Full Text
Peer Reviewed
See detailThe applicability of eGFR equations to different populations
DELANAYE, Pierre ULg; Mariat, Christophe

in Nature Reviews Nephrology (2013), 9

The Cockcroft–Gault equation for estimating glomerular filtration rate has been learnt by every generation of medical students over the decades. Since the publication of the Modification of Diet in Renal ... [more ▼]

The Cockcroft–Gault equation for estimating glomerular filtration rate has been learnt by every generation of medical students over the decades. Since the publication of the Modification of Diet in Renal Disease (MDRD) study equation in 1999, however, the supremacy of the Cockcroft–Gault equation has been relentlessly disputed. More recently, the Chronic Kidney Disease Epidemiology (CKD-EPI) consortium has proposed a group of novel equations for estimating glomerular filtration rate (GFR). The MDRD and CKD-EPI equations were developed following a rigorous process, are expressed in a way in which they can be used with standardized biomarkers of GFR (serum creatinine and/or serum cystatin C) and have been evaluated in different populations of patients. Today, the MDRD Study equation and the CKD-EPI equation based on serum creatinine level have supplanted the Cockcroft–Gault equation. In many regards, these equations are superior to the Cockcroft–Gault equation and are now specifically recommended by international guidelines. With their generalized use, however, it has become apparent that those equations are not infallible and that they fail to provide an accurate estimate of GFR in certain situations frequently encountered in clinical practice. After describing the processes that led to the development of the new GFR-estimating equations, this Review discusses the clinical situations in which the applicability of these equations is questioned. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailEcologisation : entre sciences, conventions et pratiques
Mormont, Marc ULg

in Natures Sciences Sociétés (2013), (21), 159-160

Editorial

Detailed reference viewed: 17 (3 ULg)
Full Text
Peer Reviewed
See detailSoil model systems used to assess fouling, soil adherence and surface cleanability in the laboratory: a review
Toure, Yetioman ULg; Mabon, Nicolas; Sindic, Marianne ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(3), 527-539

Surface fouling is a chronic problem in processing industries. The hygienic state of surfaces is thus a critical parameter with respect to the performance of the production process and to the final ... [more ▼]

Surface fouling is a chronic problem in processing industries. The hygienic state of surfaces is thus a critical parameter with respect to the performance of the production process and to the final quality of the product. For this reason, cleaning and disinfection are essential. The most important first step in implementing a fouling mitigation strategy through cleaning and disinfection is to understand the mechanisms of fouling. This allows ways to be found to reduce, even to eliminate fouling, or to improve the effectiveness of cleaning and disinfection. This paper reviews the relevant literature and summarizes a selection of soil model systems used to aid such improvements. Organic, mineral, microbial, particulate, and composite soil model systems are presented. These soil model systems are of particular relevance in the study of fouling, cleaning or soil adhesion onto solid surfaces in the laboratory environment. The key features of the models, as well as their practical advantages and disadvantages, are described and discussed. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailFeeding regimens and necrotizing enterocolitis
SENTERRE, Thibault ULg

in Neonatology (2013), 104(4), 263-264

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailA drifting impact oscillator with periodic impulsive loading: Application to percussive drilling
Depouhon, Alexandre ULg; Denoël, Vincent ULg; Detournay, Emmanuel

in Physica D: Nonlinear Phenomena (2013), 258(0), 1--10

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailThe role of epigenetics in malignant pleural mesothelioma
Vandermeers, Fabian; Neelature Sriramareddy, Sathya; Chrisostome, Costa et al

in Lung Cancer (2013), 81

Malignant pleural mesothelioma (MPM) is an almost invariably fatal cancer of the pleura due to asbestos exposure. Increasing evidence indicates that unresponsiveness to chemotherapy is due to epigenetic ... [more ▼]

Malignant pleural mesothelioma (MPM) is an almost invariably fatal cancer of the pleura due to asbestos exposure. Increasing evidence indicates that unresponsiveness to chemotherapy is due to epigenetic errors leading to inadequate gene expression in tumor cells. The availability of compounds that modulate epigenetic modifications, such as histone acetylation or DNA methylation, offers new prospects for treatment of MPM. Here, we review latest findings on epigenetics in mesothelioma and present novel strategies for promising epigenetic thérapies. [less ▲]

Detailed reference viewed: 27 (6 ULg)
Full Text
Peer Reviewed
See detailEndocrine Disruptors: A Most Relevant Issue for the Pediatric Endocrinologist.
BOURGUIGNON, Jean-Pierre ULg; Soder, Olle

in Hormone Research in Paediatrics (2013)

Detailed reference viewed: 5 (4 ULg)
Full Text
Peer Reviewed
See detailMeiofauna and harpacticoid copepods in different habitats of a Mediterranean seagrass meadow
Mascart, Thibaud ULg; Lepoint, Gilles ULg; De Troch, Marleen

in Journal of the Marine Biological Association of the United Kingdom (2013), 93(06), 1557-1566

This study investigated whether associated meiobenthic communities, especially harpacticoid copepods differed, amongst habitats. Five pre-defined habitats within and next to the Posidonia oceanica ... [more ▼]

This study investigated whether associated meiobenthic communities, especially harpacticoid copepods differed, amongst habitats. Five pre-defined habitats within and next to the Posidonia oceanica seagrass meadow were sampled: living seagrass canopy leaves (LL), small (SMF) and large (LMF) macrophytodetritus fragments accumulations and sand, bare (BS) and covered (CS). The highest meiofauna abundances were recorded in the BS for the core sampled habitats (BS, CS, SMF and LMF) and in the LMF for seagrass material habitats (SMF, LMF and LL). Harpacticoid copepods were the most abundant taxon in all habitats. The assemblage composition at copepod family level showed two distinct habitats clusters: a leaf (LMF and LL) and a sediment cluster (BS, CS and SMF). Subsequently, stable isotope analyses were conducted to analyse the relationship between copepods and their potential food sources in seagrass material habitats. Based on δ13C isotopic analyses and SIAR mixing model, harpacticoid copepods relied for 70% on epiphytes and for 30% on P. oceanica leaf material in the LMF and LL habitats. [less ▲]

Detailed reference viewed: 41 (7 ULg)
Full Text
Peer Reviewed
See detailRecommandations Europeennes pour la prise en charge des cardiopathies congenitales de l'adulte.
Miltner, B.; Seghaye, Marie-Christine ULg; Lancellotti, Patrizio ULg

in Revue medicale de Liege (2013), 68(9), 450-7

Improved survival of patients with congenital heart disease has increased the number of these patients at adulthood. In 2010, the European Society of Cardiology has published new guidelines for the ... [more ▼]

Improved survival of patients with congenital heart disease has increased the number of these patients at adulthood. In 2010, the European Society of Cardiology has published new guidelines for the management of grown-up congenital heart disease. They provide more detailed information on specific defects in adults. This article summarizes the guidelines for the management of the most common adult congenital heart diseases. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailPrevalence and spread of extended-spectrum β-lactamase-producing
Magoue Lonchel, Carine ULg; MELIN, Pierrette ULg; Gangoué-Piéboji, J et al

in Clinical Microbiology & Infection (2013), 19(9), 416-20

During April 2010 and June 2010, 334 Enterobacteriaceae isolates from 590 participants (outpatients, inpatients, inpatient carers, hospital workers and members of their households) were collected from ... [more ▼]

During April 2010 and June 2010, 334 Enterobacteriaceae isolates from 590 participants (outpatients, inpatients, inpatient carers, hospital workers and members of their households) were collected from faecal samples. Based on b-lactamase pattern, origin of strains and the relationship between participants, 44 isolates of extended-spectrum b-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae were selected from 44 participants (in Ngaoundere Protestant Hospital and Ngaoundere Regional Hospital, Cameroon). To determine the relatedness of bacterial strains, these isolates were fingerprinted using the automated, repetitive-sequenced-based PCR-based DiversiLab system. Subsequently, E. coli isolates that had undergone DiversiLab analysis were examined with respect to their phylogenetic group and detection of the ST131 clone to shed light on the epidemiology of these isolates in the Ngaoundere hospitals. The prevalence of faecal carriage of ESBL-producing Enterobacteriaceae among the study participants was 54.06%. According to participant groups, the prevalence of faecal carriage was also high (outpatients 45%; inpatients 67%; inpatient carers 57%; hospital workers 44%; and members of their households 46%). Analysis of the molecular epidemiology of ESBL-producing E. coli and K. pneumoniae showed a close relationship of the isolates between related and nonrelated individuals. In addition, DiversiLab results of E. coli identified four related isolates (4/22) from cluster III belonging to the epidemiologically important clone ST131. Our results highlight the importance of outpatients, inpatients, their carers, hospital workers and their families as reservoirs of ESBLproducing Enterobacteriaceae. [less ▲]

Detailed reference viewed: 25 (8 ULg)
Full Text
Peer Reviewed
See detailRisk of hip fracture in community-dwelling and institutionalized osteoporotic patients: A 3-year study.
Bruyère, Olivier ULg; Hiligsmann, Mickaël ULg; Zegels, Brigitte ULg et al

in International Journal of Gerontology (2013), 7(3), 167-70

Background and aims: It has been previously suggested that the incidence of hip fracture is higher among people living in nursing homes than among community-dwelling people. However, it is not clear ... [more ▼]

Background and aims: It has been previously suggested that the incidence of hip fracture is higher among people living in nursing homes than among community-dwelling people. However, it is not clear whether this is a consequence of nursing home residency or of the greater age of the residents. We have examined the relationship between the place of residence and hip fracture incidence, in a prospective 3- year study. Methods: Women from nine countries included in this study were part of the placebo group of a randomized controlled trial having assessed the long-term effect of a new antiosteoporotic drug. All women were osteoporotic and received placebo and vitamin D during the 3 years of follow-up. All the institutionalized (nursing home, medical house) women (n ¼ 217) were included in this post hoc analysis and three noninstitutionalized age- and country-matched controls were included (n ¼ 651). Results: The mean (and standard deviation) age of the patients was 80.4 (5.6) years in the institutionalized women and 80.2 (5.8) years in the noninstitutionalized women (p ¼ 0.87). After 3 years of followup, 37 fractures occurred: 12 (5.5%) in institutionalized women and 25 (3.8%) in noninstitutionalized women. The difference between the two groups was not statistically significant (p ¼ 0.29). After controlling for age, body mass index, femoral neck bone mineral density and prevalent nonvertebral fracture, the residence status of the patient (institutionalized vs. noninstitutionalized) was not significantly associated with hip fracture incidence (p ¼ 0.63). Conclusions: We suggest that living in an institutionalized place is not an independent risk factor for hip fracture for osteoporotic women receiving calcium and vitamin D. [less ▲]

Detailed reference viewed: 42 (21 ULg)
Full Text
Peer Reviewed
See detailFast method for the simultaneous quantification of toxic polyphenols applied to the selection of genotypes of yam bean (Pachyrhizus sp.) seeds.
Lautié, Emmanuelle; Rozet, Eric ULg; Hubert, Philippe ULg et al

in Talanta (2013), 117

The purpose of the research was to develop and validate a rapid quantification method able to screen many samples of yam bean seeds to determine the content of two toxic polyphenols, namely pachyrrhizine ... [more ▼]

The purpose of the research was to develop and validate a rapid quantification method able to screen many samples of yam bean seeds to determine the content of two toxic polyphenols, namely pachyrrhizine and rotenone. The analytical procedure described is based on the use of an internal standard (dihydrorotenone) and is divided in three steps: microwave assisted extraction, purification by solid phase extraction and assay by ultra high performance liquid chromatography (UHPLC). Each step was included in the validation protocol and the accuracy profiles methodology was used to fully validate the method. The method was fully validated between 0.25mg and 5mg pachyrrhizin per gram of seeds and between 0.58mg/g and 4mg/g for rotenone. More than one hundred samples from different accessions, locations of growth and harvest dates were screened. Pachyrrhizine concentrations ranged from 3.29mg/g to lower than 0.25mg/g while rotenone concentrations ranged from 3.53mg/g to lower than 0.58mg/g. This screening along with principal component analysis (PCA) and discriminant analysis (DA) analyses allowed the selection of the more interesting genotypes in terms of low concentrations of these two toxic polyphenols. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailGenetic variance in micro-environmental sensitivity for milk and milk quality in Walloon Holstein cattle
Vandenplas, Jérémie ULg; Bastin, Catherine ULg; Gengler, Nicolas ULg et al

in Journal of Dairy Science (2013), 96

Animals that are robust to environmental changes are desirable in the current dairy industry. Genetic differences in micro-environmental sensitivity can be studied through heterogeneity of residual ... [more ▼]

Animals that are robust to environmental changes are desirable in the current dairy industry. Genetic differences in micro-environmental sensitivity can be studied through heterogeneity of residual variance between animals. However, residual variance between animals is usually assumed homogeneous in traditional genetic evaluations. The aim of this study was to investigate genetic heterogeneity of residual variance by estimating variance components in residual variance for milk yield, somatic cell score, contents in milk (g/dL) of two groups of milk fatty acids (i.e. saturated fatty acids and unsaturated fatty acids) and the content in milk of one individual fatty acid (i.e. the oleic acid, C18:1 cis-9), for first-parity Holstein cows in the Walloon Region of Belgium. A total of 146,027 test-day records from 26,887 cows in 747 herds were available. All cows had at least three records and had a known sire. These sires had at least 10 cows with records and each herd x test-day had at least five cows. The five traits were analyzed separately based on fixed lactation curve and random regression test-day models for the mean. Estimation of variance components was performed by running iteratively Expectation Maximization-Restricted Maximum Likelihood algorithm by the implementation of double hierarchical generalized linear models. Based on fixed lactation curve test-day mean models, heritability for residual variances ranged between 1.01*10-3 and 4.17*10-3 for all traits. The genetic standard deviation in residual variance (i.e. approximately the genetic coefficient of variation of residual variance) ranged between 0.12 and 0.17. Therefore, some genetic variance in micro-environmental sensitivity existed in the Walloon Holstein dairy cattle for the five studied traits. The standard deviations due to herd x test-day and permanent environment in residual variance ranged between 0.36 and 0.45 for herd x test-day effect and between 0.55 and 0.97 for permanent environmental effect. Therefore, non-genetic effects also contributed substantially to the micro-environmental sensitivity. Results also showed that the addition of random regressions to the mean model did not reduce heterogeneity in residual variance and that genetic heterogeneity of residual variance was not simply an effect of an incomplete mean model. [less ▲]

Detailed reference viewed: 59 (38 ULg)
Full Text
Peer Reviewed
See detailThree-dimensional reconstruction of the pharyngeal tonsil innervation pattern in sheep
Toppets, Vinciane ULg; Piret, Joëlle ULg; Gabriel, Annick ULg et al

in Journal of Neuroimmunology (2013), (262), 79-84

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailLe religieux et le sacré vus à travers l’iconographie de l’olfaction
Dondero, Maria Giulia ULg

in Questions de Communication (2013), 23

This article explores the representation of olfactory sensoriality in modern religious painting as conveyed by the movement of clouds, and thus raises the question of the relationship between the ... [more ▼]

This article explores the representation of olfactory sensoriality in modern religious painting as conveyed by the movement of clouds, and thus raises the question of the relationship between the religious dimension of faith and the sacred contagion of transcendence. The representation of olfaction in pictorial iconography is compared with the disappearance of the holy bodies in contemporary artistic photography and perfume advertising. Interpretive propositions about the distinction of the religious and the sacred in relation to three corpuses are developed with a semiotic methodology. [less ▲]

Detailed reference viewed: 28 (0 ULg)
Full Text
Peer Reviewed
See detailLa dépression chez les mères adolescentes : pour un repérage des situations de vulnérabilité
Noirhomme-Renard, Florence ULg; Aujoulat, Isabelle; Gosset, Christiane ULg

in Neuropsychiatrie de l'Enfance et de l'Adolescence (2013), 61

Introduction and objectives Due to the high frequency and co-occurrence of vulnerabilities, mothers under 20 years are at higher risk of perinatal depression than adults mothers. We performed a review of ... [more ▼]

Introduction and objectives Due to the high frequency and co-occurrence of vulnerabilities, mothers under 20 years are at higher risk of perinatal depression than adults mothers. We performed a review of the literature investigating the epidemiology of adolescents mothers’ depression, compared these data to adult mothers and listed associated factors, to develop a more preventive approach and specific follow-up. Methods The review is based on Pubmed and Sciencedirect research combining “adolescent” or “teenage” and “depression” as keywords. Results Seventeen international studies were included, evaluating both prenatal (6 studies) and postnatal (14 studies) depression with three different scales (CES-D, BDI, EPDS). Depression rate in adolescents mothers varies from 26 to 63% in the third trimester of pregnancy and from 26 to 61% in the first 3 months postpartum, with differences depending of studies designs, screening instruments and cut-offs. Depression rate declines with time, but still persists with a prevalence ranging from 21 to 32% at 4 to 5 years after delivery. Depression rate in adolescent mothers are globally twice higher than in adult mothers, both in prenatal and postnatal periods. Characteristics associated with adolescent mothers depression include sociodemographic factors (less education, low income), psychosocial factors (confidence, self-esteem), poor or inadequate social support and negative life events (violence exposure, history of abuse). Conclusion Perinatal depression in adolescent mothers is very high and can contribute negatively to child-mother interaction. It should be a priority to screen depression early during pregnancy and to offer appropriate support services during the first years of motherhood. Moreover, it could be of high interest to assess maternofoetal attachment during pregnancy using validated instruments combined with depression scales. [less ▲]

Detailed reference viewed: 71 (28 ULg)
Full Text
See detailLe bois de Robinier faux-acacia: propriétés physiques, mécaniques et de durabilité naturelle
Pollet, Caroline; Verheyen, Cécile; Hebert, Jacques ULg et al

in Forêt Wallonne (2013), 126

Suite à une étude réalisée par le Laboratoire de Technologie du Bois du DEMNA et l’ULG, concernant les propriétés mécaniques, physiques et de durabilité naturelle du bois de robinier fauxacacia, nous ... [more ▼]

Suite à une étude réalisée par le Laboratoire de Technologie du Bois du DEMNA et l’ULG, concernant les propriétés mécaniques, physiques et de durabilité naturelle du bois de robinier fauxacacia, nous proposons de revenir sur les qualités annoncées de ce bois, qui pourrait permettre d’envisager non seulement de ne pas avoir recours à l’utilisation de produits de préservation mais également d’offrir une alternative crédible à l’usage des essences tropicales généralement proposées en menuiserie extérieure. [less ▲]

Detailed reference viewed: 50 (7 ULg)
Full Text
Peer Reviewed
See detailPrésentation et traduction de Franz Brentano, "Philosophie scientifique et philosophie des préjugés" (1903)
Dewalque, Arnaud ULg

in Philosophie (2013), 119

Le texte traduit ici est tiré d’un recueil réunissant plusieurs écrits du philosophe allemand Franz Brentano (1838-1917) et publié en 1925 par son disciple Alfred Kastil sous le titre Essai sur la ... [more ▼]

Le texte traduit ici est tiré d’un recueil réunissant plusieurs écrits du philosophe allemand Franz Brentano (1838-1917) et publié en 1925 par son disciple Alfred Kastil sous le titre Essai sur la connaissance. La pièce maîtresse du recueil est un manuscrit de Brentano intitulé « À bas les préjugés ! », portant le sous-titre : « Une exhortation pour inciter l’époque actuelle à renoncer, dans l’esprit de Bacon et de Descartes, à tous les a priori aveugles » (1903). Nous avons traduit la première partie de ce texte, dans laquelle Brentano s’attaque simultanément au common sense du philosophe écossais Thomas Reid et aux jugements synthétiques a priori d’Immanuel Kant. Cet extrait constitue l’un des rares documents dans lesquels Brentano expose sans détours son opposition radicale à un certain kantisme et, plus largement, à toute forme de constructivisme. Brentano s'attaque à l'idée kantienne du synthétique a priori, en jetant les bases d'un programme gnoséologique dont l'axe central est l'exhibition des sources empiriques de nos concepts fondamentaux (substance, cause, être, nécessité, etc.). Ce programme sera développé à son tour par Carl Stumpf ('Erkenntnislehre', 1939). [less ▲]

Detailed reference viewed: 92 (10 ULg)
Full Text
Peer Reviewed
See detailBordetella pertussis seroprevalence in Belgian adults aged 20–39 years, 2012
Huygen, K; Rodeghiero, C; Govaerts, Daniele et al

in Epidemiology & Infection (2013)

The last report on pertussis seroprevalence in Belgium concerned samples collected during 1993–1994. In the context of the Eupert-Labnet WP6 seroprevalence study (comparing sera from 16 European member ... [more ▼]

The last report on pertussis seroprevalence in Belgium concerned samples collected during 1993–1994. In the context of the Eupert-Labnet WP6 seroprevalence study (comparing sera from 16 European member states), 1500 anonymized leftover diagnostic samples were collected randomly during the second semester of 2012 by the clinical chemistry laboratories of six participating Belgian centres, distributed equally between Flanders, Wallonia and Brussels Capital Region. As suggested by the WP6 organizers, a total of 750 samples (125/centre) were selected from subjects in the 20–29 years age group and 750 samples (125/centre) from subjects in the 30–39 years age group. Anti-PT IgG levels were measured using Virion-Serion ELISA and analysed using predefined cut-off levels. Sixty-one (4%) sera were indicative of an infection in the past 2 years (between 50 and 100 IU/ml) and another 61 (4%) sera had anti-PT IgG antibodies reflecting acute infection (>100 IU/ml). These results highlight the presence of a Bordetella pertussis reservoir in the adult ‘healthy’ Belgian population [less ▲]

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailAnalyse des pratiques de détection des chaleurs dans les élevages bovins laitiers algériens.
Yahimi, Abdelkrim; Djellata, N; Hanzen, Christian ULg et al

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (2013), 66(1), 31-35

Methods used to detect estrus were analyzed in 222 cattle farms, spread over five wilayas center (Tizi Ouzou, Blida, Medea, Tipaza and Bouira) in Algeria. The questionnaire contained general information’s ... [more ▼]

Methods used to detect estrus were analyzed in 222 cattle farms, spread over five wilayas center (Tizi Ouzou, Blida, Medea, Tipaza and Bouira) in Algeria. The questionnaire contained general information’s related to livestock (number of females, stall, and specialisation) but also the methods of heat detection (periods of observation signs considered as important) and any complementary tool used. The majority of farmers (57%) were facing a problem of heat detection. In only 49% of cases, they inseminated their cows for the first time 50 to 90 days after calving. A breeder in two (53%) detected oestrus twice a day and 40% observed three times a day. Observations took place whenever suitable in the day. They declared that a cow was in oestrus primarily on the presence of a vulvar discharge (19%) or mount acceptance (16%). Herd size or specialisation had no impact on the frequency of signs considered. Cows not detected in estrus during the first 60 days after calving were subjected to a clinical examination by a veterinarian in76% of farms. Some helps to the detection such as (rotating schedule, pencil mark) were used by 34% of farms. These practices are influenced (factors responsible for the manifestation, times and number of observation, anestrus post-partum and aids detections of heat) or no (signs of heat, waiting period and difficulty of detection) by speculation and herd size. [less ▲]

Detailed reference viewed: 65 (2 ULg)
Full Text
Peer Reviewed
See detailRural electrification through decentralized concentrating solar power: technological and socio-economic aspects
Quoilin, Sylvain ULg; Orosz, Matthew

in Journal of Sustainable Development of Energy, Water and Environment Systems (2013), 1(3), 199-212

This paper presents the development of small-scale solar Organic Rankine Cycles for rural electrification in remote areas of Lesotho. It is subdivided in two parts. The first part deals with the success ... [more ▼]

This paper presents the development of small-scale solar Organic Rankine Cycles for rural electrification in remote areas of Lesotho. It is subdivided in two parts. The first part deals with the success conditions of decentralized rural electrification projects. Through a literature survey, relevant guiding principles and recommendations are formulated. The second part of the paper describes the proposed system, which is designed in agreement with the formulated recommendations. A framework for benchmarking the performance and cost of various micro-utility platforms and rural electrification distribution models is proposed. [less ▲]

Detailed reference viewed: 60 (9 ULg)
Full Text
Peer Reviewed
See detailFatty acids and associated cardiovascular risk
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Leroy, Ludovic et al

in Food and Nutrition Sciences (2013), 4(9A), 188-194

Background: A fatty acid (FA) is a carboxylic acid with a long aliphatic chain, which is either saturated or unsaturated. Recently, the role of FA and particularly omega-3 and -6 has emerged as ... [more ▼]

Background: A fatty acid (FA) is a carboxylic acid with a long aliphatic chain, which is either saturated or unsaturated. Recently, the role of FA and particularly omega-3 and -6 has emerged as cardiovascular risk factor in the literature. The aim of our study was to establish reference values for these FA and to compare them with data obtained in a population of acute myocardial infarction (AMI) patients. Materials and methods: Hundred thirty five healthy subjects (59.38 ± 27.12 yo, 75 men) were selected as reference population. We also evaluated FA in thirty three patients (55 ± 9 yo, 23 men) admitted in the Emergency Department of our Institution for AMI. The fasting whole blood was drawn in vacutainer containing EDTA. Before analysis, samples were washed and transmethylated. We performed the quantification of different FA by gas chromatography associated with flame ionisation detector (GCFID). Results: We obtained results in control healthy patients to be used as reference values. In the AMI group, levels of omega-6 were significantly higher (p<0.05) for C18:2n6 and C18:3n6 than the reference population and omega-3 values were significantly lower (p<0.01) compared to reference value for C22:6n3. The omega-3 index was lower and the ratio omega-6/omega-3 was higher in AMI group compared to reference values. Conclusions: We have established reference value for FA and have compared these values with the results obtained in AMI population. FA determination is a new tool we are able to use and to process in our laboratory which can help the clinician to screen patients with the highest cardiovascular risks because of the implication of FA in the etiopathogeny of atherosclerosis. [less ▲]

Detailed reference viewed: 16 (9 ULg)
Full Text
Peer Reviewed
See detailLe point sur l'exigence du "bref délai" dans l'action en garantie contre les vices cachés
Kohl, Benoît ULg; Onclin, François ULg

in Journal des Tribunaux (2013), 29/2013(n° 6531), 560-564

La garantie des vices cachés appartient à l’obligation générale de garantie qui pèse sur le vendeur, et vise à permettre à l’acheteur une possession utile de la chose. Cette obligation est organisée par ... [more ▼]

La garantie des vices cachés appartient à l’obligation générale de garantie qui pèse sur le vendeur, et vise à permettre à l’acheteur une possession utile de la chose. Cette obligation est organisée par les articles 1641 et suivants du Code civil. À cet égard, l’article 1648 du même Code impose à l’acquéreur d’introduire son action en garantie dans un « bref délai ». Le législateur ne détaille cependant pas davantage les contours de ce délai. Tout au plus, se borne-t-il à préciser que le bref délai est déterminé « suivant la nature des vices rédhibitoires et l’usage du lieu où la vente a été faite »1. Ce laconisme a suscité de nombreuses interrogations et discussions, tant en doctrine qu’en jurisprudence, autour de la notion du bref délai. Plusieurs décisions récentes nous semblent toutefois trancher certaines de ces controverses, tout en en suscitant de nouvelles. Cette contribution fait le point sur l’exigence du bref délai dans la matière de la garantie des vices cachés. [less ▲]

Detailed reference viewed: 45 (16 ULg)
Full Text
Peer Reviewed
See detailMonte Carlo search algorithm discovery for single-player games
Maes, Francis; Lupien St-Pierre, David ULg; Ernst, Damien ULg

in IEEE Transactions on Computational Intelligence and AI in Games (2013), 5(3), 201-213

Much current research in AI and games is being devoted to Monte Carlo search (MCS) algorithms. While the quest for a single unified MCS algorithm that would perform well on all problems is of major ... [more ▼]

Much current research in AI and games is being devoted to Monte Carlo search (MCS) algorithms. While the quest for a single unified MCS algorithm that would perform well on all problems is of major interest for AI, practitioners often know in advance the problem they want to solve, and spend plenty of time exploiting this knowledge to customize their MCS algorithm in a problem-driven way. We propose an MCS algorithm discovery scheme to perform this in an automatic and reproducible way. We first introduce a grammar over MCS algorithms that enables inducing a rich space of candidate algorithms. Afterwards, we search in this space for the algorithm that performs best on average for a given distribution of training problems. We rely on multi-armed bandits to approximately solve this optimization problem. The experiments, generated on three different domains, show that our approach enables discovering algorithms that outperform several well-known MCS algorithms such as Upper Confidence bounds applied to Trees and Nested Monte Carlo search. We also show that the discovered algorithms are generally quite robust with respect to changes in the distribution over the training problems. [less ▲]

Detailed reference viewed: 22 (9 ULg)
Full Text
Peer Reviewed
See detailThe global grid
Chatzivasileiadis, Spyros; Ernst, Damien ULg; Andersson, Göran

in Renewable Energy : An International Journal (2013), 57

This paper puts forward the vision that a natural future stage of the electricity network could be a grid spanning the whole planet and connecting most of the large power plants in the world: this is the ... [more ▼]

This paper puts forward the vision that a natural future stage of the electricity network could be a grid spanning the whole planet and connecting most of the large power plants in the world: this is the “Global Grid”. The main driving force behind the Global Grid will be the harvesting of remote renewable sources, and its key infrastructure element will be the high capacity long transmission lines. Wind farms and solar power plants will supply load centers with green power over long distances. This paper focuses on the introduction of the concept, showing that a globally interconnected network can be technologically feasible and economically competitive. We further highlight the multiple opportunities emerging from a global electricity network such as smoothing the renewable energy supply and electricity demand, reducing the need for bulk storage, and reducing the volatility of the energy prices. We also discuss possible investment mechanisms and operating schemes. Among others, we envision in such a system a global power market and the establishment of two new coordinating bodies, the “Global Regulator” and the “Global System Operator”. [less ▲]

Detailed reference viewed: 74 (17 ULg)
Full Text
Peer Reviewed
See detailGeschoeid op Engelse leest
Steyaert, Kris ULg

in Spiegel der Letteren (2013), 55(3), 411-413

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detailDiagnosis and follow-up of monoclonal gammopathies of undetermined significance; information for referring physicians.
CAERS, Jo ULg; Vekemans, Marie-Christiane; Bries, Greet et al

in Annals of Medicine (2013), 45

The prevalence of monoclonal gammopathy of undetermined significance (MGUS) is generally estimated at 3.4% in the general population over 50 years, and its incidence increases with age. MGUS represents a ... [more ▼]

The prevalence of monoclonal gammopathy of undetermined significance (MGUS) is generally estimated at 3.4% in the general population over 50 years, and its incidence increases with age. MGUS represents a preneoplastic entity that can transform into multiple myeloma or other lymphoproliferative disorders. The risk of malignant transformation is estimated at 1% per year and persists over time. Predictors of malignant transformation have been identified such as the heavy chain isotype, the monoclonal component level, increasing levels of M-protein during the first years of follow-up, bone marrow plasmocytosis, dosage of serum free light chains, the presence of immunophenotypic abnormal plasma cells, aneuploidy and the presence of circulating plasma cells. Prognostic scores that combine certain of these factors have been proposed and allow the identification of high-risk patients. Their use could assist in tailoring the care for each patient, based on his/her risk profile. [less ▲]

Detailed reference viewed: 32 (7 ULg)
Full Text
Peer Reviewed
See detailA new role for histone deacetylase 5 in the maintenance of long telomeres.
Novo, Clara Lopes; Polese, Catherine ULg; Matheus, Nicolas ULg et al

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2013), 27

Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin ... [more ▼]

Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin remodeling is probably the least studied; thus, we intended to explore the role of a specific histone deacetylase on telomere maintenance. We uncovered a new role for histone deacetylase 5 (HDAC5) in telomere biology. We report that HDAC5 is recruited to the long telomeres of osteosarcoma- and fibrosarcoma-derived cell lines, where it ensures proper maintenance of these repetitive regions. Indeed, depletion of HDAC5 by RNAi resulted in the shortening of longer telomeres and homogenization of telomere length in cells that use either telomerase or an alternative mechanism of telomere maintenance. Furthermore, we present evidence for the activation of telomere recombination on depletion of HDAC5 in fibrosarcoma telomerase-positive cancer cells. Of potential importance, we also found that depletion of HDAC5 sensitizes cancer cells with long telomeres to chemotherapeutic drugs. Cells with shorter telomeres were used to control the specificity of HDAC5 role in the maintenance of long telomeres. HDAC5 is essential for the length maintenance of long telomeres and its depletion is required for sensitization of cancer cells with long telomeres to chemotherapy. -Novo, C. L., Polese, C., Matheus, N., Decottignies, A., Londono-Vallejo, A., Castronovo, V., Mottet, D. A new role for histone deacetylase 5 in the maintenance of long telomeres. [less ▲]

Detailed reference viewed: 78 (24 ULg)
Full Text
Peer Reviewed
See detailL'amende fiscale en matière TVA sous la loupe de la Cour constitutionnelle
Michiels, Olivier ULg

in Revue de Droit Pénal et de Criminologie (2013), (7-8), 738-747

La note d'observations sous l'arrêt prononcé par la Cour constitutionnelle le 21 février 2013 ( n°13/2013) analyse la nature juridique de l'amende portée par l'article 70 § 2 du Code TVA, le pouvoir d ... [more ▼]

La note d'observations sous l'arrêt prononcé par la Cour constitutionnelle le 21 février 2013 ( n°13/2013) analyse la nature juridique de l'amende portée par l'article 70 § 2 du Code TVA, le pouvoir d'appréciation du juge fiscal à l'égard de cette amende et les mesures d'individualisation dont ce dernier dispose. [less ▲]

Detailed reference viewed: 59 (12 ULg)
Full Text
Peer Reviewed
See detailEffect of inventory plot patterns in the floristic analysis of tropical woodland and dense forest
Houeto, Georges; Glele Kakai, Romain L.; Salako, Valère et al

in African Journal of Ecology (2013), 51(3),

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailGlycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration
Avila Macaya, Ariel Salvatore ULg; Vidal, Pia M; Dear, T Neil et al

in Cell Reports (2013)

Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical ... [more ▼]

Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis. [less ▲]

Detailed reference viewed: 20 (9 ULg)
Full Text
Peer Reviewed
See detailGroup B streptococcal epidemiology and vaccine needs in developed countries
MELIN, Pierrette ULg; EFSTRATIOU, Androulla

in Vaccine (2013), 31(Supplement 4), 31-42

Development of a group B streptococcal vaccine (GBS) vaccine is the most promising approach for the prevention of GBS infections in babies, given the potential adverse effects of intrapartum antibiotic ... [more ▼]

Development of a group B streptococcal vaccine (GBS) vaccine is the most promising approach for the prevention of GBS infections in babies, given the potential adverse effects of intrapartum antibiotic prophylaxis as well as the need for effective prevention of both adult and late perinatal disease. There are numerous prevention strategies at this time but none are 100% effective in the eradication of neonatal early onset GBS disease and there are no preventative strategies for late onset disease. The need for a GBS vaccine is therefore, of utmost importance. Efforts applying genomics to GBS vaccine development have led to the identification of novel vaccine candidates. The publication of GBS whole genomes coupled with new technologies including multigenome screening and bioinformatics has also allowed researchers to overcome the serotype limitation of earlier vaccine preparations in the search of a universal effective vaccine against GBS. This review brings together the key arguments concerning the potential need of a GBS vaccine in developed countries and describes the current status with GBS epidemiology and microbiology in these countries. [less ▲]

Detailed reference viewed: 22 (3 ULg)