References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailA stable inversion method for feedforward control of constrained flexible multibody systems
Bruls, Olivier ULg; Bastos, Guaraci Jr.; Seifried, Robert

in Journal of Computational and Nonlinear Dynamics (2014), 9(1), 011014

The inverse dynamics of flexible multibody systems is formulated as a two-point boundary value problem for an index-3 differential-algebraic equation (DAE). This DAE represents the equation of motion with ... [more ▼]

The inverse dynamics of flexible multibody systems is formulated as a two-point boundary value problem for an index-3 differential-algebraic equation (DAE). This DAE represents the equation of motion with kinematic and trajectory constraints. For so-called nonminimum phase systems, the remaining dynamics of the inverse model is unstable. Therefore, boundary conditions are imposed not only at the initial time but also at the final time in order to obtain a bounded solution of the inverse model. The numerical solution strategy is based on a reformulation of the DAE in index-2 form and a multiple shooting algorithm, which is known for its robustness and its ability to solve unstable problems. The paper also describes the time integration and sensitivity analysis methods that are used in each shooting phase. The proposed approach does not require a reformulation of the problem in input-output normal form known from nonlinear control theory. It can deal with serial and parallel kinematic topology, minimum phase and nonminimum phase systems, and rigid and flexible mechanisms. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailEffects of limestone fillers on surface free energy and electrical conductivity of the interstitial solution of cement mixes
Courard, Luc ULg; Michel, Frédéric ULg; Perkowicz, Sylwia et al

in Cement and Concrete Composites (2014), 45

Most of concrete formulations actually contain mineral additives that are used as an inert filler or supplementary cementitious material (as type II addition). These materials are generally used in order ... [more ▼]

Most of concrete formulations actually contain mineral additives that are used as an inert filler or supplementary cementitious material (as type II addition). These materials are generally used in order to increase concrete performances both in its fresh and hardened states. The mineral additives usually improve the consistency and workability of fresh concrete and reduce the water demand for a required concrete slump because of an additional volume of fines. The way of action depends on the physical and chemical characteristics of fillers. The study of surface free energies and electric conductivities of interstitial solutions of cement mixes modified by blast furnace slags and limestone fillers contributes to a better knowledge of hardening and interaction process. [less ▲]

Detailed reference viewed: 44 (5 ULg)
Full Text
Peer Reviewed
See detailWater soluble exo-polysaccharide from Syncephalastrum racemosum, a strong inducer of plant defence reactions
Valepyn, Emmanuel ULg; Cabrera, Juan-Carlos; Richel, Aurore ULg et al

in Carbohydrate Polymers (2014), 101

This study examines the production, characterization and bioactivity on plant cell cultured in vitro of exopolysaccharides (EPS) from Syncephalastrum racemosum CBS 443.59. Firstly, the influence of the ... [more ▼]

This study examines the production, characterization and bioactivity on plant cell cultured in vitro of exopolysaccharides (EPS) from Syncephalastrum racemosum CBS 443.59. Firstly, the influence of the fungus culture condition in shake flasks (pH, temperature and different carbon and nitrogen sources) on EPS and biomass production were evaluated. In order to enhance EPS production, a new protocol based on two-stage pH fermentation in a 3 L stirred fermentor was developed. Under this condition, EPS production increased by 3.55 times, compared to a constant pH process, reaching a maximal EPS concentration of 2.62 g/L. Structurally, the EPS contains a polyglucuronic acid backbone, linked essentially with mannose and fucose units and some galactose and glucose units. The bioactivity of EPS as inducer of defence reactions in plant suspension-cultured cells was also studied. Our results show, for first time, that EPS from S. racemosum CBS 443.59 induces, depending on the concentration, PAL activation and H2O2 synthesis in Arabidospsis thaliana cell suspensions. [less ▲]

Detailed reference viewed: 26 (7 ULg)
Full Text
Peer Reviewed
See detailModelling the Holocene migrational dynamics of Fagus sylvatica L. and Picea abies (L.) H. Karst
Lehsten, Lehsten; Dullinger, Stefan; Hülber, Karl et al

in Global Ecology and Biogeography (2014)

Aim: Vegetation dynamics and the competitive interactions involved are assumed to restrict the ability of species to migrate. But in most migration modelling approaches disturbance-driven succession and ... [more ▼]

Aim: Vegetation dynamics and the competitive interactions involved are assumed to restrict the ability of species to migrate. But in most migration modelling approaches disturbance-driven succession and competition processes are reduced to simple assumptions or are even missing. The aim of this study was to test a combination of a migration model and a dynamic vegetation model to estimate the migration of tree species controlled by climate, environment and local species dynamics such as succession and competition. Location: Europe. Methods: To estimate the effect of vegetation dynamics on the migration of European beech and Norway spruce, we developed a post-process migration tool (LPJ-CATS). This tool integrates outputs of the migration model CATS and the dynamic vegetation model LPJ-GUESS. The model LPJ-CATS relies on a linear dependency between the dispersal kernel and migration rate and is based on the assumption that competition reduces fecundity. Results: Simulating potential migration rates with the CATS model, which does not account for competition and disturbance, resulted in mean Holocene migra- tion rates of 435 ± 55 and 330 ± 95 m year−1 for the two species Picea abies and Fagus sylvatica, respectively. With LPJ-CATS, these mean migration rates were reduced to 250 ± 75 and 170 ± 60 m year−1 for spruce and beech, respectively. Moreover, LPJ-CATS simulated migration pathways of these two species that gen- erally comply well with those documented in the palaeo-records. Main conclusions: Our ‘hybrid’ modelling approach allowed for the simulation of generally realistic Holocene migration rates and pathways of the two study species on a continental scale. It suggests that competition can considerably modify spread rates, but also the magnitude of its effect depends on how close climate conditions are to the niche requirements of a particular species. [less ▲]

Detailed reference viewed: 34 (17 ULg)
Full Text
Peer Reviewed
See detailLe canon littéraire au crible des Physiologies
Stienon, Valérie ULg

in Revue d'Histoire Littéraire de la France (2014), 1

Gustave Lanson considérait les productions mineures comme le tissu conjonctif de l’histoire littéraire. Un tel point de vue peut rapidement faire apparaître les Physiologies parisiennes des années 1830 ... [more ▼]

Gustave Lanson considérait les productions mineures comme le tissu conjonctif de l’histoire littéraire. Un tel point de vue peut rapidement faire apparaître les Physiologies parisiennes des années 1830-1845 comme le laboratoire de bien des esthétiques modernes, ce corpus étant d’autant plus inventif qu’il procède pour une grande part des poétiques d’écriture hybrides et expansives de la presse. Parce qu'elles sont enclines à traiter du personnel, des lieux et des pratiques littéraires à partir d'une fraction symboliquement réprouvée, sinon marginale, de la production littéraire, les Physiologies peuvent assumer tout à la fois une fonction de régulation et de révélation des processus de légitimation. L'article met en évidence ce double rôle d'élucidation et d'observation participante manifestée par ces textes. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailLe droit pour le prévenu de comparaître personnellement devant les juridictions répressives
Michiels, Olivier ULg

in Revue de Droit Pénal et de Criminologie (2014), 1/2014(janvier), 113-119

La note rappelle les règles belges relatives à la comparution du prévenu personne physique devant les juridictions répressives en les mettant en parallèle avec la jurisprudence de la Cour européenne des ... [more ▼]

La note rappelle les règles belges relatives à la comparution du prévenu personne physique devant les juridictions répressives en les mettant en parallèle avec la jurisprudence de la Cour européenne des droits de l'homme. Elle s'attache ensuite à examiner la question de l'incapacité pour une partie d'être présente à son procès. [less ▲]

Detailed reference viewed: 28 (3 ULg)
Full Text
Peer Reviewed
See detailA vibrotactile P300-based BCI for consciousness detection and communication
Lugo, Zulay; Rodriguez, Javi; Lechner, Alexander et al

in Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)

Brain–computer interface (BCI) has been used for many years for communication in severely disabled patients. BCI based on electrophysiological signals has enabled communication, using auditory or visual ... [more ▼]

Brain–computer interface (BCI) has been used for many years for communication in severely disabled patients. BCI based on electrophysiological signals has enabled communication, using auditory or visual stimuli to elicit event-related potentials (ERPs). The aim of this study was to determine whether patients with locked-in syndrome (LIS) could elicit a P300 wave, using a vibrotactile oddball paradigm for establishing somatosensory BCI-based communication. Six chronic LIS patients performed 2electroencephalography (EEG)-based vibrotactile P300 oddball tasks. After a simple mental counting task of the target stimuli, participants were instructed to answer 5 questions by counting the vibration on either the right wrist for “yes” or the left wrist for “no.” All participants were able to elicit a P300 wave using the vibrotactile oddball paradigm BCI task. In the counting task, 4 patients got accuracies of 100% (average above chance). In the communication task, one patient achieved 100% accuracy (average above chance). We have shown the feasibility of eliciting a P300 response using vibrotactile stimulation in patients with LIS. The present study provides evidence that this approach can be used for EEG-based BCI communications in this patient group. This is the first study to prove the feasibility of a BCI based on somatosensory (vibratory) stimulation in a group of braininjured patients. Furthermore, this approach could be used for the detection of consciousness in non-communicating patients due to severe brain injuries. [less ▲]

Detailed reference viewed: 50 (4 ULg)
Full Text
Peer Reviewed
See detailIsolation of an amylolytic chrysophyte, Poterioochromonas sp. from the digestive tract of the termite R. santonensis
Tarayre, Cédric ULg; Bauwens, Julien ULg; Brasseur, Catherine ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(1),

The aim of this work was the isolation and cultivation of amylolytic protists living in the digestive tract of the termite Reticulitermes santonensis (Feytaud). A chrysophyte identified as ... [more ▼]

The aim of this work was the isolation and cultivation of amylolytic protists living in the digestive tract of the termite Reticulitermes santonensis (Feytaud). A chrysophyte identified as Poterioochromonas sp. was isolated in a special medium containing rice grains as a source of carbon and nitrogen. Then, the protist was grown in a medium containing starch as a carbon source, tryptone, and a phosphate buffer at different pH values (5, 6 and 7). Yeast extract was added or not. Ciprofloxacin was used to avoid the bacterial development. Other antibiotics were also tested but showed an inhibitive effect on the growth of Poterioochromonas sp. Yeast extract allowed reaching 1.9 (pH 5), 2.3 (pH 6) and 2.2 (pH 7) times higher final cell concentrations, and 2.8 (pH 5), 2.8 (pH 6) and 2.2 (pH 7) times higher biomass yields. The starch concentration did not decrease in the medium until 3 and 4 days of culture, with and without yeast extract, respectively. Eight days of culture were necessary for hydrolyzing the starch completely, with and without yeast extract. Maltose and maltotriose were detected in the culture media and were hydrolyzed progressively. Maximal maltose concentrations were 0.68, 0.66 and 0.51 g.l-1 in the medium containing yeast extract. Maltotriose concentrations were only 0.17, 0.14 and 0.12 g.l-1. Other glucose oligomers were also detected but in lower quantities. It was determined that the protist developed a weak amylase activity, particularly at a weakly acidic pH (5-6). Such a pH also allowed a better growth of the protist. A maximal amylase activity of 112 nkat.l-1 was measured with yeast extract at pH 5. No other enzymatic activity (protease, cellulase or xylanase) was detected except amylase. The degradation products of starch which were obtained by enzymatic hydrolysis allow the identification of α-amylase, amyloglucosidase and possibly β-amylase activities. [less ▲]

Detailed reference viewed: 44 (14 ULg)
Full Text
Peer Reviewed
See detailFourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria
Wybo, Ingrid; Van den Bossche; Soetens, Oriane et al

in Journal of Antimicrobial Chemotherapy (2014), 69

Objectives: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre ... [more ▼]

Objectives: To collect recent data on the susceptibility of anaerobes to antimicrobial agents with known activity against anaerobes, and to compare them with results from previous Belgian multicentre studies. Methods: Four hundred and three strict anaerobic clinical isolates were prospectively collected from February 2011 to April 2012 in eight Belgian university hospitals. MICs were determined by one central laboratory for 11 antimicro- bial agents using Etest methodology. Results: According to EUCAST breakpoints, .90% of isolates were susceptible to amoxicillin/clavulanate (94%), piperacillin/tazobactam (91%), meropenem (96%), metronidazole (92%) and chloramphenicol (98%), but only 70% and 40% to clindamycin and penicillin, respectively. At CLSI recommended breakpoints, only 71% were sus- ceptible to moxifloxacin and 79% to cefoxitin. MIC50/MIC90 values for linezolid and for tigecycline were 1/4 and 0.5/ 4 mg/L, respectively. When compared with survey data from 2004, no major differences in susceptibility profiles were noticed. However, the susceptibility of Prevotella spp. and other Gram-negative bacilli to clindamycin decreased from 91% in 1993 – 94 and 82% in 2004 to 69% in this survey. Furthermore, the susceptibility of clostridia to moxifloxacin decreased from 88% in 2004 to 66% in 2011 – 12 and that of fusobacteria from 90% to 71%. Conclusions: Compared with previous surveys, little evolution was seen in susceptibility, except a decline in activity of clindamycin against Prevotella spp. and other Gram-negative bacteria, and of moxifloxacin against clostridia. Since resistance was detected to all antibiotics, susceptibility testing of anaerobic isolates is indicated in severe infections to confirm appropriateness of antimicrobial therapy. [less ▲]

Detailed reference viewed: 17 (2 ULg)
Peer Reviewed
See detailA 3400 year lacustrine paleoseismic record from the North Anatolian Fault, Turkey: Implications for bimodal recurrence behavior
Avsar, Ulas; Hubert, Aurelia ULg; De Batist, Marc et al

in Geophysical Research Letters (2014), 41(2), 377-384

High-resolution physical, geochemical, and geochronological analyses on the sedimentary sequence of Yeniçağa Lake, located in a fault-bounded basin along the North Anatolian Fault, reveal fingerprints of ... [more ▼]

High-resolution physical, geochemical, and geochronological analyses on the sedimentary sequence of Yeniçağa Lake, located in a fault-bounded basin along the North Anatolian Fault, reveal fingerprints of paleoearthquakes. A robust sediment chronology, spanning the last 3400 years, is constructed by radiocarbon dating and time-stratigraphical correlation with the precisely dated Sofular Cave speleothem record. Yeniçağa sedimentary sequence contains 11 seismically induced event deposits characterized by siliciclastic-enriched intervals. Some of the event deposits are also associated with implications of sudden lake deepening, which may be related to coseismic subsidence. The paleoearthquake series having an average recurrence interval of ca. 260 years are interrupted by two possible seismic gaps of ca. 420 and 540 years. [less ▲]

Detailed reference viewed: 42 (14 ULg)
Full Text
Peer Reviewed
See detailDétermination des propriétés de couches dans le béton à l'aide d'un géoradar commercial à hautes fréquences: approche pic-à-pic et analyse fréquentielle du coefficient de réflexion
Van der Wielen, Audrey ULg; Nguyen, Frédéric ULg; Courard, Luc ULg

in Annales du Bâtiment et des Travaux Publics (2014)

The Ground Penetrating Radar (GPR) is an efficient tool for the non-destructive inspection of concrete structures. It is widely used for the detection of rebars or humid zones or for evaluating the ... [more ▼]

The Ground Penetrating Radar (GPR) is an efficient tool for the non-destructive inspection of concrete structures. It is widely used for the detection of rebars or humid zones or for evaluating the thickness of elements. But when an element contains a thin layer, the radar waves are submitted to multiple reflections on the interfaces and the layer appears in the radargram as a single reflection, whose detailed analysis can allow determining the thickness and the permittivity of the thin layer. Two approaches were considered in this paper. In the first one, the analysis is based on the peak-to-peak reflection amplitude. The second approach uses a frequency analysis of the reflection coefficient, whose amplitude and phase can then be calculated for several frequencies. With this method, the thickness and permittivity of the layer can in theory be simultaneously determined. Both methods were numerically validated through finite difference simulations and experimentally tested on concrete samples containing an air layer of variable thickness. We showed that the frequency analysis allowed to reach a higher precision in the parameters estimation for a limited additional computing cost. The method efficiency depends on the conditions and is optimal for layers with a high permittivity presenting a large contrast with the matrix. [less ▲]

Detailed reference viewed: 27 (2 ULg)
Peer Reviewed
See detailA 3400 year lacustrine paleoseismic record from the North Anatolian Fault, Turkey: Implications for bimodal recurrence behavior
Avsar, Ulas; Hubert, Aurelia ULg; De Batist, Marc et al

in Geophysical Research Letters (2014), 41(2), 377-384

High-resolution physical, geochemical, and geochronological analyses on the sedimentary sequence of Yeniçağa Lake, located in a fault-bounded basin along the North Anatolian Fault, reveal fingerprints of ... [more ▼]

High-resolution physical, geochemical, and geochronological analyses on the sedimentary sequence of Yeniçağa Lake, located in a fault-bounded basin along the North Anatolian Fault, reveal fingerprints of paleoearthquakes. A robust sediment chronology, spanning the last 3400 years, is constructed by radiocarbon dating and time-stratigraphical correlation with the precisely dated Sofular Cave speleothem record. Yeniçağa sedimentary sequence contains 11 seismically induced event deposits characterized by siliciclastic-enriched intervals. Some of the event deposits are also associated with implications of sudden lake deepening, which may be related to coseismic subsidence. The paleoearthquake series having an average recurrence interval of ca. 260 years are interrupted by two possible seismic gaps of ca. 420 and 540 years. [less ▲]

Detailed reference viewed: 42 (14 ULg)
Full Text
Peer Reviewed
See detailAntiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)
Kopa, T.K.; Tchinda Tiabou, Alembert ULg; Tala, M.F. et al

in Phytochemistry Letters (2014), 8

Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolation of one new anthraquinone derivative, grandiquinone A (3-acetoxy-8-hydroxy-2-methylanthraquinone) (1 ... [more ▼]

Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolation of one new anthraquinone derivative, grandiquinone A (3-acetoxy-8-hydroxy-2-methylanthraquinone) (1), along with nine known compounds: 5,8-dihydroxy-2-methylanthraquinone (2), hydroxysesamone (3), 3-hydroxy-2-methylanthraquinone (4), quinizarine (5), betulinic acid (6), ursolic acid (7), tectograndone (8), corosolic acid (9) and sitosterol 3-O-β-d-glucopyranoside (10). Compounds 2 and 3 were isolated for the first time from the leaves of this plant, while 5 has never been reported from the genus Tectona. Hydroxysesamone (3) and tectograndone (8) were subjected to cyclisation and acetylation reactions to afford two hemisynthetic derivatives, 6,9-dihydroxy-2,2-(dimethyldihydropyrano)-3,4-dihydro-2H-benzo[g]chromene-5,10-dione (11) and acetyltectograndone (12) respectively, which are reported here for the first time. The ethyl acetate-soluble portion, some of the isolated compounds and hemisynthetic derivatives were evaluated for their antiplasmodial activity against the multidrug-resistant Dd2 strain of Plasmodium falciparum. Compound 3 showed a prominent activity, while 2, 8, 9, 11 and 12 showed significant in vitro anti-malarial activity. Compound 1 was weakly active in this test. The structures of the compounds were elucidated by spectroscopic methods and comparison of the data with the literature. [less ▲]

Detailed reference viewed: 30 (2 ULg)
Full Text
Peer Reviewed
See detailA climate analysis tool for passive heating and cooling strategies in hot humid climate based on Typical Meteorological Year data sets
Nguyen, Anh Tuan ULg; Reiter, Sigrid ULg

in Energy & Buildings (2014), 68(Part C), 756-763

Through a newly developed climate analysis tool, this paper examines the potential of improving thermal comfort under the climates of Vietnam thanks to passive strategies. A Building climatic chart for ... [more ▼]

Through a newly developed climate analysis tool, this paper examines the potential of improving thermal comfort under the climates of Vietnam thanks to passive strategies. A Building climatic chart for Vietnamese was proposed based on Fanger’s theory [1] and the comfort zone of this chart was then extended by calculating the effects of passive heating and cooling strategies. Typical Meteorological Year weather data are used for extracting and graphically printing of hourly environmental parameters on the psychrometric chart and for climate analysis, subsequently. The limitation and the scope of this method are also specified. The climates of three climatic regions in Vietnam have been used as case studies using all year, seasonal and monthly analysis. The results show that natural ventilation is an effective cooling solution as thermal comfort improvement varies with the climatic zones, increasing from 24.8% in Hanoi, 22.1% in Danang to 32.0% in Hochiminh city. Meanwhile, passive solar heating is only effective under the climate of Hanoi. Direct evaporative cooling also shows great cooling potential for comfort improvement but probable elevated humidity is not expected. Total possible comfort in a year of each location indicates that further climate modification methods are inevitable to achieve comfort during extreme weather conditions, especially in Hanoi. [less ▲]

Detailed reference viewed: 132 (23 ULg)
Full Text
Peer Reviewed
See detailAutomated analysis of background EEG and reactivity during therapeutic hypothermia in comatose patients after cardiac arrest
Noirhomme, Quentin ULg; Lehembre, Rémy; Lugo, Zulay et al

in Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)

Visual analysis of electroencephalography (EEG) background and reactivity during therapeutic hypothermia provides important outcome information, but is time-consuming and not always consistent between ... [more ▼]

Visual analysis of electroencephalography (EEG) background and reactivity during therapeutic hypothermia provides important outcome information, but is time-consuming and not always consistent between reviewers. Automated EEG analysis may help quantify the brain damage. Forty-six comatose patients in therapeutic hypothermia, after cardiac arrest, were included in the study. EEG background was quantified with burst-suppression ratio (BSR) and approximate entropy, both used to monitor anesthesia. Reactivity was detected through change in the power spectrum of signal before and after stimulation. Automatic results obtained almost perfect agreement (discontinuity) to substantial agreement (background reactivity) with a visual score from EEG-certified neurologists. Burst-suppression ratio was more suited to distinguish continuous EEG background from burst-suppression than approximate entropy in this specific population. Automatic EEG background and reactivity measures were significantly related to good and poor outcome. We conclude that quantitative EEG measurements can provide promising information regarding current state of the patient and clinical outcome, but further work is needed before routine application in a clinical setting. [less ▲]

Detailed reference viewed: 41 (13 ULg)
Full Text
Peer Reviewed
See detailNeutralising properties of peptides derived from CXCR4 extracellular loops towards CXCL12 binding and HIV-1 infection
Chevigné, Andy; Fievez, Virginie; Szpakowska, Martyna ULg et al

in Biochimica et Biophysica Acta-Molecular Cell Research (2014)

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailA 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock
Kumar Kadri, Naveen; Sahana, Goutam; Charlier, Carole ULg et al

in PLoS Genetics (2014), 10(1), 1004049

In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has ... [more ▼]

In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has concomitantly severely declined. It is generally assumed that this reduction is primarily due to the negative energy balance of high-producing cows at the peak of lactation. We herein describe the fine-mapping of a major fertility QTL in Nordic Red cattle, and identify a 660-kb deletion encompassing four genes as the causative variant. We show that the deletion is a recessive embryonically lethal mutation. This probably results from the loss of RNASEH2B, which is known to cause embryonic death in mice. Despite its dramatic effect on fertility, 13%, 23% and 32% of the animals carry the deletion in Danish, Swedish and Finnish Red Cattle, respectively. To explain this, we searched for favorable effects on other traits and found that the deletion has strong positive effects on milk yield. This study demonstrates that embryonic lethal mutations account for a non-negligible fraction of the decline in fertility of domestic cattle, and that associated positive effects on milk yield may account for part of the negative genetic correlation. Our study adds to the evidence that structural variants contribute to animal phenotypic variation, and that balancing selection might be more common in livestock species than previously appreciated. [less ▲]

Detailed reference viewed: 31 (6 ULg)
Full Text
Peer Reviewed
See detailAn Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics.
Matheus, Nicolas ULg; Hansen, Sylvain ULg; Rozet, Eric ULg et al

in Phytochemical analysis : PCA (2014)

INTRODUCTION: As a complement to the classic metabolomics biofluid studies, the visualisation of the metabolites contained in cells or tissues could be a very powerful tool to understand how the local ... [more ▼]

INTRODUCTION: As a complement to the classic metabolomics biofluid studies, the visualisation of the metabolites contained in cells or tissues could be a very powerful tool to understand how the local metabolism and biochemical pathways could be affected by external or internal stimuli or pathologies. Therefore, extraction and/or lysis is necessary to obtain samples adapted for use with the current analytical tools (liquid NMR and MS). These extraction or lysis work-ups are often the most labour-intensive and rate-limiting steps in metabolomics, as they require accuracy and repeatability as well as robustness. Many of the procedures described in the literature appear to be very time-consuming and not easily amenable to automation. OBJECTIVE: To find a fast, simplified procedure that allows release of the metabolites from cells and tissues in a way that is compatible with NMR analysis. METHODS: We assessed the use of sonication to disrupt cell membranes or tissue structures. Both a vibrating probe and an automated bath sonicator were explored. RESULTS: The application of sonication as the disruption procedure led to reproducible NMR spectral data compatible with metabolomics studies. This method requires only a small biological tissue or cell sample, and a rapid, reduced work-up was applied before analysis. The spectral patterns obtained are comparable with previous, well-described extraction protocols. CONCLUSION: The rapidity and the simplicity of this approach could represent a suitable alternative to the other protocols. Additionally, this approach could be favourable for high- throughput applications in intracellular and intratissular metabolite measurements. Copyright (c) 2014 John Wiley & Sons, Ltd. [less ▲]

Detailed reference viewed: 55 (21 ULg)
Full Text
Peer Reviewed
See detailSubjective Evaluation of the Audiovisual Spatial Congruence in the Case of Stereoscopic-3D Video and Wave Field Synthesis
André, Cédric ULg; Corteel, Etienne; Embrechts, Jean-Jacques ULg et al

in International Journal of Human-Computer Studies (2014), 72(1), 23-32

While 3D cinema is becoming increasingly established, little effort has focused on the general problem of producing a 3D sound scene spatially coherent with the visual content of a stereoscopic-3D (s-3D ... [more ▼]

While 3D cinema is becoming increasingly established, little effort has focused on the general problem of producing a 3D sound scene spatially coherent with the visual content of a stereoscopic-3D (s-3D) movie. The perceptual relevance of such spatial audiovisual coherence is of significant interest. In this paper, a subjective experiment is carried out where an angular error between an s-3D video and a spatially accurate sound reproduced through Wave Field Synthesis (WFS) is simulated. The psychometric curve is measured with the method of constant stimuli, and the threshold for bimodal integration is estimated. The impact of the presence of background noise is also investigated. A comparison is made between the case without any background noise and the case with an SNR of 4 dB(A). Estimates of the thresholds and the slopes, as well as their confidence intervals, are obtained for each level of background noise. When background noise was present, the point of subjective equality (PSE) was higher (19.4° instead of 18.3°) and the slope was steeper (-0.077 instead of -0.062 per degree). Because of the overlap between the confidence intervals, however, it was not possible to statistically differentiate between the two levels of noise. The implications for the sound reproduction in a cinema theater are discussed. [less ▲]

Detailed reference viewed: 113 (19 ULg)
Full Text
Peer Reviewed
See detailA Management Control Perspective of Sustainability Reporting in Higher Education: In Search of a Holistic View
Ceulemans, Kim; Van Caillie, Didier ULg; Molderez, Ingrid et al

in ACRN Journal of Entrepreneurship Perspectives (2014), III(1), 1-17

Higher education institutions have been actively attempting to integrate sustainability in their curricula, research, operations, and outreach activities over the last decades. Despite the efforts ... [more ▼]

Higher education institutions have been actively attempting to integrate sustainability in their curricula, research, operations, and outreach activities over the last decades. Despite the efforts undertaken, it is currently still challenging for their internal and external stakeholders to assess an institution’s sustainability-related activities and the extent of their implementation within the different activities of higher education. Since sustainability reporting in higher education is currently still in its early stages, and because a holistic view of sustainability integration in higher education on a management level is often lacking, this paper researches possible contributions of management control to sustainability reporting and the sustainability integration process in higher education. The paper adheres to a management control approach by applying Simons’ (1995) Levers of Control Framework to the field of sustainability in higher education, in search for a theoretical framework for reporting and integrating sustainability on a strategic level into higher education institutions. The research stresses the need for a holistic approach and for further in-depth study into certain aspects of the control framework, i.e., practical implementation of vision and mission statements, the concept of materiality, staff development, diagnostic indicator development, and the study of stakeholder engagement processes in higher education [less ▲]

Detailed reference viewed: 46 (2 ULg)
Full Text
Peer Reviewed
See detailHollow Cylinder Tests on Boom Clay: Modelling of Strain Localization in the Anisotropic Excavation Damaged Zone
François, B; Labiouse, V; Dizier, A et al

in Rock Mechanic and Rock Engineering (2014), 47(1), 71-86

Detailed reference viewed: 35 (8 ULg)
Full Text
See detailAssessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography.
Gosseries, Olivia ULg; Thibaut, Aurore ULg; Boly, Mélanie ULg et al

in Annales Françaises d'Anesthésie et de Réanimation (2014)

Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of ... [more ▼]

Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of awareness in severely brain-injured patients is challenging because it relies on behavioral assessments, which can be affected by motor, sensory and cognitive impairments of the patients. Other means of evaluation are needed to improve the accuracy of the diagnosis in this challenging population. We will here review the different altered states of consciousness occurring after severe brain damage, and explain the difficulties associated with behavioral assessment of consciousness. We will then describe a non-invasive technique, transcranial magnetic stimulation combined with high-density electroencephalography (TMS-EEG), which has allowed us to detect the presence or absence of consciousness in different physiological, pathological and pharmacological states. Some potential underlying mechanisms of the loss of consciousness will then be discussed. In conclusion, TMS-EEG is highly promising in identifying markers of consciousness at the individual level and might be of great value for clinicians in the assessment of consciousness. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Full Text
Peer Reviewed
See detailConsciousness and Unconsciousness: An EEG Perspective
Noirhomme, Quentin ULg; Laureys, Steven ULg

in Clinical EEG and Neuroscience (2014), 45

Detailed reference viewed: 24 (2 ULg)
Full Text
See detailEntre permis forestier et permis minier, la diff icile émergence des forêts communautaires au Gabon
Morin, Amélie; Meunier, Quentin; Moumbogou et al

in Parcs et Réserves (2014), 68(4), 16-22

A l’heure de l’attribution des premières forêts communautaires au Gabon, de multiples questions surgissent et attendent de manière urgente une réponse de la part de l’Etat. Le présent article se penche ... [more ▼]

A l’heure de l’attribution des premières forêts communautaires au Gabon, de multiples questions surgissent et attendent de manière urgente une réponse de la part de l’Etat. Le présent article se penche sur l’une d’entre elles, à savoir la superposition des permis d’exploitation (minier, forestier) avec l’espace utilisé traditionnellement par les communautés locales et candidates à l’obtention d’une forêt communautaire. Quelques situations rencontrées sur le terrain sont présentées et discutées. Il est urgent qu’un réel aménagement du territoire voie le jour au Gabon, qui détermine la place de chaque activité, hiérarchise l’affectation de l’espace et détermine le cas échéant les conditions de « cohabitation » de plusieurs permis. [less ▲]

Detailed reference viewed: 80 (14 ULg)
Full Text
Peer Reviewed
See detailLombostat au long cours versus école du dos périodique
Tomasella, Marco ULg; Demoulin, Christophe ULg; Vanderthommen, Marc ULg et al

in Revue Belge du dommage corporel et de médecine légale (2014), 41ème année(2014/1), 3-12

Detailed reference viewed: 48 (6 ULg)
Full Text
See detailLa voix n'est pas infatigable
Tréger, Isabelle; Remacle, Angélique ULg

in L'Orthophoniste (2014), 335

Detailed reference viewed: 33 (6 ULg)
Full Text
See detailPolitique budgétaire et décision politique: gérer un système fédéral complexe
Piron, Damien ULg

in Revue Nouvelle (2014), 69(1), 61-71

En Belgique, la décision politique repose depuis la fin du XIXème siècle sur le modèle consociatif: des compromis sont conclus entre les "piliers" issus des clivages philosophique et économique. L ... [more ▼]

En Belgique, la décision politique repose depuis la fin du XIXème siècle sur le modèle consociatif: des compromis sont conclus entre les "piliers" issus des clivages philosophique et économique. L'intégration européenne et la fédéralisation redessinent néanmoins cette méthode de gouvernement, ainsi que le montre la comparaison des politiques d'assainissement des finances publiques conduites par les gouvernements Dehaene Ier et Di Rupo. Le modèle fédéral engendre en effet une multiplication du nombre d'acteurs impliqués dans la prise de décision, ce qui complique l'élaboration de compromis. Il appartient donc aux acteurs politiques de maintenir le système belge gouvernable en imaginant des procédures adaptées à cette nouvelle réalité. [less ▲]

Detailed reference viewed: 54 (5 ULg)
Full Text
Peer Reviewed
See detailMarket Power in the Credit Rating Industry: State of Play and Proposal for Reforms
Candelon, Bertrand; Gautier, Axel ULg; Petit, Nicolas ULg

in CPI Antitrust Chronicle (2014), 2

In recent years, the Credit Rating Agencies (“CRAs”) have been in the eye of the storm. Some argue that CRA rating errors—symptomatized by rating inflation or deflation—originate in excessive competition ... [more ▼]

In recent years, the Credit Rating Agencies (“CRAs”) have been in the eye of the storm. Some argue that CRA rating errors—symptomatized by rating inflation or deflation—originate in excessive competition. This paper argues that the low level of competition in credit rating is a better explanation for rating this phenomenon. [less ▲]

Detailed reference viewed: 33 (4 ULg)
Full Text
Peer Reviewed
See detailRobust method optimization strategy – a useful tool for method transfer: the case of SFC
Dispas, Amandine ULg; Lebrun, Pierre ULg; Andri, Bertyl ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2014), 88

The concept of Quality by Design (QbD) is now well established in pharmaceutical industry and should be applied to the development of any analytical methods. In this context, the key concept of Design ... [more ▼]

The concept of Quality by Design (QbD) is now well established in pharmaceutical industry and should be applied to the development of any analytical methods. In this context, the key concept of Design Space (DS) was introduced in the field of analytical method optimization. In chromatographic words, the DS is the space of chromatographic conditions that will ensure the quality of peaks separation, thus DS is a zone of robustness. In the present study, the interest of robust method optimization strategy was investigated in the context of direct method transfer from sending to receiving laboratory. The benefit of this approach is to speed up the method life cycle by performing only one quantitative validation step in the final environment of method use. A Supercritical Fluid Chromatography (SFC) method previously developed was used as a case study in this work. Moreover, the interest of geometric transfer was investigated simultaneously in order to stress a little bit more the transfer exercise and, by the way, emphasize the additional benefit of DS strategy in this particular context. Three successful transfers were performed on two column geometries. In order to compare original and transferred methods, the observed relative retention times (RT) were modelled as a function of the predicted relative RT and of the method type (original or transferred). The observed relative RT of the original and transferred methods are not statistically different and thus the method transfer is successfully achieved thanks to the robust optimization strategy. Furthermore, the analytical method was improved considering analysis time (reduced five times) and peak capacity (increased three times). To conclude, the advantage of using a DS strategy implemented for the optimization and transfer of SFC method was successfully demonstrated in this work. [less ▲]

Detailed reference viewed: 55 (17 ULg)
Full Text
Peer Reviewed
See detailThe 24-h recall instrument for home nursing to measure the activity profile of home nurses:development and psychometric testing
De Vliegher, Kristel; Aaertgeerts, Bert; Declercq, Anja et al

in Primary Health Care Research & Development (2014)

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailAn ecological study of Electra posidoniae Gautier, 1954 (Cheilostomata, Anasca), a bryozoan epiphyte solely found on the seagrass Posidonia oceanica (L.) Delile, 1813
Lepoint, Gilles ULg; Mouchette, Olivier; Pelaprat, Corine et al

in Belgian Journal of Zoology (2014), 144(1), 51-63

The bryozoan Electra posidoniae Gautier is found solely on the leaves of the Neptune grass Posidonia oceanica (L.) Delile, dominating the leaf epifauna of this seagrass. Epiphytes of marine angiosperms ... [more ▼]

The bryozoan Electra posidoniae Gautier is found solely on the leaves of the Neptune grass Posidonia oceanica (L.) Delile, dominating the leaf epifauna of this seagrass. Epiphytes of marine angiosperms (or seagrasses) often play an important role in ecosystem functioning, for example as food web suppliers. As dysfunction of epiphytic compartment is often implied in human-induced seagrass decline, it is important to understand the dynamics and life traits of this community in pristine areas. This study involved the monthly assessment of colonization dynamics, biomass seasonality and diet composition through stable isotopes measurements of E. posidoniae at a depth of 10 m in the Revellata Bay (Corsica, Mediterranean Sea). Ancestrulae (i.e. colony founders) appeared towards the end of winter and were very selective in their settlement position along the P. oceanica leaves. A maximum of 100,000 colonies per square meter was recorded. E. posidoniae colonies dominated the epiphytic community biomass in early spring, and were over-covered by epiphytic algae in June. Food shortage could be also involved in this decrease. Although stable isotope ratios of C, N and S showed that this suspension feeder mainly relies on the water column productivity for its food, other food sources such as re-suspended epiphytic diatoms could be important in late spring (i.e. after the phytoplanktonic bloom). Additionally, a contribution of seagrass phytodetritus to the diet of this species cannot be excluded. The species was almost absent in winter, raising the question of its recruitment in spring. This study confirms the quantitative importance of this species in the seagrass meadow and explores its role in the relationship between the water column and this seagrass ecosystem. [less ▲]

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailDIRECTED INFORMATION TRANSFER IN SCALP ELECTROENCEPHALOGRAPHIC RECORDINGS: INSIGHTS ON DISORDERS OF CONSCIOUSNESS
Marinazzo, Daniele; Gosseries, Olivia ULg; Boly, Mélanie ULg et al

in Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) (2014)

Introduction: The neural mechanisms underlying electrophysiological changes observed in patients with disorders of consciousness following a coma remain poorly understood. The aim of this article is to ... [more ▼]

Introduction: The neural mechanisms underlying electrophysiological changes observed in patients with disorders of consciousness following a coma remain poorly understood. The aim of this article is to investigate the mechanisms underlying the differences in spontaneous electroencephalography between patients in vegetative/unresponsive wakefulness syndrome, minimally conscious state, emergence of the minimally conscious state and age-matched healthy control subjects. <br />Methods: Forty recording of spontaneous scalp electroencephalography were performed in 27 patients who were comatose on admission, and on healthy controls. Multivariate Granger Causality and Transfer Entropy were applied on the data. <br />Results: Distinctive patterns of putative bottlenecks of information were associated to each conscious state. Healthy controls are characterized by a greater amount of synergetic contributions from duplets of variables. <br />Conclusion: A novel set of measures was tested to get a novel insight on the pattern of information transfer in a network of scalp electrodes in patients with disorders of consciousness. [less ▲]

Detailed reference viewed: 42 (6 ULg)
Full Text
Peer Reviewed
See detail2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.
Brignole, Michele; Auricchio, Angelo; Baron-Esquivias, Gonzalo et al

in Revista espanola de cardiologia (English ed.) (2014), 67(1), 58

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailRecommandations européennes pour la prise en charge des cardiopathies congénitales complexes de l'adulte
MILTNER, Béatrice ULg; LANCELLOTTI, Patrizio ULg; SEGHAYE, Marie-Christine ULg

in Revue Médicale de Liège (2014), 69(1), 16-25

THe number of patients with Grown-Up Congenital Heart disease (GUCH) consulting adult cardiologists is steadily increasing. These patients have either a non-diagnosed congenital heart disease revealed at ... [more ▼]

THe number of patients with Grown-Up Congenital Heart disease (GUCH) consulting adult cardiologists is steadily increasing. These patients have either a non-diagnosed congenital heart disease revealed at adulthood, or a diagnosed congenital heart disease for which one or multiple interventions have possibly been performed during childhood. In this article, we summarize the recommendations of the European Society of Cardiology of 2010 for complex congenital heart disease. [less ▲]

Detailed reference viewed: 43 (4 ULg)
Full Text
Peer Reviewed
See detailEffect of zolpidem in chronic disorders of consciousness: a prospective open-label study.
Thonnard, Marie ULg; Gosseries, Olivia ULg; Demertzi, Athina ULg et al

in Functional Neurology (2014)

Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty ... [more ▼]

Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty patients (35±15 years; 18 females; mean time since insult ± SD: 4±5.5 years; 31 with traumatic etiology) with a diagnosis of vegetative state/unresponsive wakefulness syndrome (n=28) or minimally conscious state (n=32) were behaviorally assessed using the Coma Recovery Scale-Revised (CRS-R) before and one hour after administration of 10 mg of zolpidem. At the group level, the diagnosis did not change after intake of zolpidem (p=0.10) and CRS-R total scores decreased (p=0.01). Twelve patients (20%) showed improved behaviors and/or CRS-R total scores after zolpidem administration but in only one patient was the diagnosis after zolpidem intake found to show a significant improvement (functional object use), which suggested a change of diagnosis. However, in this patient, a double-blind placebo-controlled trial was performed in order to better specify the effects of zolpidem, but the patient, on this trial, failed to show any clinical improvements. The present open-label study therefore failed to show any clinically significant improvement (i.e., change of Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study diagnosis) in any of the 60 studied chronic DOC patients. [less ▲]

Detailed reference viewed: 34 (4 ULg)
Full Text
Peer Reviewed
See detailCharacterization of Lactobacillus strains isolated from Algerian children faeces for their probiotic properties
Bahri, F.; Lejeune, Annick ULg; Dubois-Dauphin, R. et al

in African Journal of Microbiology Research [=AJMR] (2014), 8(3), 297-303

Lactic acid bacteria termed probiotics have preventive as well as curative effects on several types of diarrhoea of different aetiologies. The main objective of this study was to screen lactobacilli ... [more ▼]

Lactic acid bacteria termed probiotics have preventive as well as curative effects on several types of diarrhoea of different aetiologies. The main objective of this study was to screen lactobacilli strains having probiotic traits, isolated from Algerian healthy children faeces on the purpose of using them further in children diarrheal illnesses. One hundred and twenty (120) lactic acid bacteria isolates were selected from faecal samples of healthy Algerian children aged between five and ten years. Gram positive rods and catalase negative bacteria (52 isolates) were screened, in vitro, for their probiotic potential properties including ability to survive in simulated gastro-intestinal conditions, adherence to Caco-2 cells and their antimicrobial activity. The results show that only five strains resisted in simulated gastric juice at pH 1.5 and pepsin. Four of them were resistant to simulated intestinal conditions at pH 8 and pancreatin and have a good adherence. In the end, three of them were retained as they display interesting probiotic profiles characterized by a strong antimicrobial effect against some intestinal pathogenic bacteria. They were identified by 16S rDNA sequencing as Lactobacillus plantarum F12, Lactobacillus brevis G6 and Lactobacillus paracasei B13. [less ▲]

Detailed reference viewed: 38 (4 ULg)
Full Text
Peer Reviewed
See detailDe l’Européanisation à la régionalisation des politiques d’intégration en Wallonie.
Martiniello, Marco ULg

in Migrations Société (2014), 26(151), 2-28

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailPrix de transfert des biens incorporels : état des lieux
Schleck, Daniel ULg

in Comptabilité et Fiscalité Pratiques (2014), 1

Detailed reference viewed: 47 (12 ULg)
Full Text
Peer Reviewed
See detailA review on simulation-based optimization methods applied to building performance analysis
Nguyen, Anh Tuan ULg; Reiter, Sigrid ULg; Rigo, Philippe ULg

in Applied Energy (2014), 113

Recent progress in computer science and stringent requirements of the design of “greener” buildings put forwards the research and applications of simulation-based optimization methods in the building ... [more ▼]

Recent progress in computer science and stringent requirements of the design of “greener” buildings put forwards the research and applications of simulation-based optimization methods in the building sector. This paper provides an overview on this subject, aiming at clarifying recent advances and outlining potential challenges and obstacles in building design optimization. Key discussions are focused on handling discontinuous multi-modal building optimization problems, the performance and selection of optimization algorithms, multi-objective optimization, the application of surrogate models, optimization under uncertainty and the propagation of optimization techniques into real-world design challenges. This paper also gives bibliographic information on the issues of simulation programs, optimization tools, efficiency of optimization methods, and trends in optimization studies. The review indicates that future researches should be oriented towards improving the efficiency of search techniques and approximation methods (surrogate models) for large-scale building optimization problems; and reducing time and effort for such activities. Further effort is also required to quantify the robustness in optimal solutions so as to improve building performance stability. [less ▲]

Detailed reference viewed: 154 (17 ULg)
Full Text
Peer Reviewed
See detailLa transposition didactique en français langue étrangère et seconde
Bento, Margaret; Defays, Jean-Marc ULg; Meunier, Deborah ULg

in Français dans le Monde. Revue Internationale et Francophone des Professeurs de Français. Recherches et Applications (2014), 55

Detailed reference viewed: 60 (8 ULg)
Full Text
Peer Reviewed
See detailRisk Taking of Executives under Different Incentive Contracts: Experimental Evidence
Lefebvre, Mathieu ULg; Vieider, Ferdinand

in Journal of Economic Behavior & Organization (2014), 97

Classic financial agency theory recommends compensation through stock options rather than shares to counteract excessive risk aversion in agents. In a setting where any kind of risk taking is suboptimal ... [more ▼]

Classic financial agency theory recommends compensation through stock options rather than shares to counteract excessive risk aversion in agents. In a setting where any kind of risk taking is suboptimal for shareholders, we show that excessive risk taking may occur for one of two reasons: risk preferences or incentives. Even when compensated through restricted company stock, experimental CEOs take large amounts of excessive risk. This contradicts classical financial theory, but can be explained through risk preferences that are not uniform over the probability and outcome spaces, and in particular, risk seeking for small probability gains and large probability losses. Compensation through options further increases risk taking as expected. We show that this effect is driven mainly by the personal asset position of the experimental CEO, thus having deleterious effects on company performance. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailL'écosystème d'innovation universitaire de Aalto : une contribution au repérage des acteurs impliqués lors de la phase d'émergence
Froehlicher, Thomas ULg; Barès, Franck

in Management International = International Management = Gestión Internacional (2014), 18(1), 153-165

The aim of this article is to better under- stand how the innovation ecosystem of Aalto University, in Helsinki, Finland, was structured in the early 2000s. Relying on an analysis of secondary data as ... [more ▼]

The aim of this article is to better under- stand how the innovation ecosystem of Aalto University, in Helsinki, Finland, was structured in the early 2000s. Relying on an analysis of secondary data as well as on the principles of a structural analy- sis of the network, we located the actors and their connections over the emergence period of this ecosystem. The results show the coexistence of two spaces organized as socio-cognitive networks able to interact and reinforce each other. A territorialized space, focused on an innovation dynamic built on the convergence strategy of the three university rectors involved at Aalto; and a deterritorialized space built by a community of actors focused on the affir- mation of proposals and ideas to imple- ment new innovation governance practices. [less ▲]

Detailed reference viewed: 31 (3 ULg)
Full Text
Peer Reviewed
See detailAutograph/Holograph and Authorial Manuscripts in Arabic Script [Conference Review]
Franssen, Elise ULg

in Comparative Oriental Manuscript Studies Newsletter (2014), 7

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailSensitivity analysis for multibody systems formulated on a Lie group
Sonneville, Valentin ULg; Bruls, Olivier ULg

in Multibody System Dynamics (2014), 31

A direct differentiation method and an adjoint variable method are proposed for the efficient semi-analytical evaluation of the sensitivities of multibody systems formulated in a matrix Lie group ... [more ▼]

A direct differentiation method and an adjoint variable method are proposed for the efficient semi-analytical evaluation of the sensitivities of multibody systems formulated in a matrix Lie group framework. These methods rely on the linearization of the equations of motion and/or of the time integration procedure. The simpler structure of the equations of motion in the Lie group formalism appears as an advantage for that purpose. Lie bracket contributions and the non-linearity of the exponential map need to be taken into account in the sensitivity algorithms. Nevertheless, essential characteristics of formulations of the direct differentiation method and the adjoint variable method on linear spaces are recovered. Some implementation issues are discussed and two relevant examples illustrate the properties of these methods. [less ▲]

Detailed reference viewed: 67 (15 ULg)
Full Text
See detailLa qualité d'accueil fait débat
Pirard, Florence ULg

in Revue [Petite] Enfance (2014), 113

La qualité des services d'accueil et d'éducation des jeunes enfants constitue un enjeu sociétal d'actualité, mais peut faire l'objet d'interprétations multiples. Fondé sur les résultats d'une recherche ... [more ▼]

La qualité des services d'accueil et d'éducation des jeunes enfants constitue un enjeu sociétal d'actualité, mais peut faire l'objet d'interprétations multiples. Fondé sur les résultats d'une recherche menée dans une démarche de théorisation ancrée, cet article donne de manière synthétique une grille de lecture de différentes manières de considérer la qualité des services d'accueil et d'éducation des jeunes enfants dans un cadre professionnel. [less ▲]

Detailed reference viewed: 24 (8 ULg)
Full Text
Peer Reviewed
See detailA More Than 20% Increase in Deceased-Donor Organ Procurement and Transplantation Activity After the Use of Donation After Circulatory Death.
Le Dinh, H.; MONARD, Josée ULg; DELBOUILLE, Marie-Hélène ULg et al

in Transplantation proceedings (2014), 46(1), 9-13

BACKGROUND: Organ procurement and transplant activity from controlled donation after circulatory death (DCD) was evaluated over an 11-year period to determine whether this program influenced the ... [more ▼]

BACKGROUND: Organ procurement and transplant activity from controlled donation after circulatory death (DCD) was evaluated over an 11-year period to determine whether this program influenced the transplant and donation after brain death (DBD) activities. MATERIAL AND METHODS: Deceased donor (DD) procurement and transplant data were prospectively collected in a local database for retrospective review. RESULTS: There was an increasing trend in the potential and actual DCD numbers over time. DCD accounted for 21.9% of the DD pool over 11 years, representing 23.7% and 24.2% of the DD kidney and liver pool, respectively. The DBD retrieval and transplant activity increased during the same time period. Mean conversion rate turning potential into effective DCD donors was 47.3%. Mean DCD donor age was 54.6 years (range, 3-83). Donors >/=60 years old made up 44.1% of the DCD pool. Among referred donors, reasons for nondonation were medical contraindications (33.7%) and family refusals (19%). Mean organ yield per DCD donor was 2.3 organs. Mean total procurement warm ischemia time was 19.5 minutes (range, 6-39). In 2012, 17 DCD and 37 DBD procurements were performed in the Liege region, which has slightly >1 million inhabitants. CONCLUSIONS: This DCD program implementation enlarged the DD pool and did not compromise the development of DBD programs. The potential DCD pool might be underused and seems to be a valuable organ donor source. [less ▲]

Detailed reference viewed: 37 (15 ULg)
Full Text
Peer Reviewed
See detailQu'apportent les nouvelles recommandations américaines à propos de la prise en charge des dyslipidémies en prévention cardiovasculaire ? Comparaison avec les recommandations européennes et belges
Descamps, O; Rietzschel, E; Langlois, M et al

in Louvain Medical (2014), 133(1), 26-35

Les dernières recommandations américaines concernant la prise en charge des dyslipidémies en prévention cardiovasculaire ont soulevé de nombreuses questions par leurs différences avec nos approches ... [more ▼]

Les dernières recommandations américaines concernant la prise en charge des dyslipidémies en prévention cardiovasculaire ont soulevé de nombreuses questions par leurs différences avec nos approches habituelles. Entre autres, elles ont éradiqué la nécessité de « cible » de LDL-C à atteindre en fonction du niveau de risque cardiovasculaire et ont proposé plutôt une stratégie basée sur l’intensité de la réduction relative du LDL-C. L’examen critique et la comparaison des recommandations font apparaitre, toutefois, plus de similitudes que de différences, tout en encourageant à repenser certains aspects de notre pratique et à raviver notre motivation pour le plus grand bien des patients. [less ▲]

Detailed reference viewed: 60 (5 ULg)
Full Text
Peer Reviewed
See detailSensitivity analysis for multibody systems formulated on a Lie group
Sonneville, Valentin ULg; Bruls, Olivier ULg

in Multibody System Dynamics (2014), 31

A direct differentiation method and an adjoint variable method are proposed for the efficient semi-analytical evaluation of the sensitivities of multibody systems formulated in a matrix Lie group ... [more ▼]

A direct differentiation method and an adjoint variable method are proposed for the efficient semi-analytical evaluation of the sensitivities of multibody systems formulated in a matrix Lie group framework. These methods rely on the linearization of the equations of motion and/or of the time integration procedure. The simpler structure of the equations of motion in the Lie group formalism appears as an advantage for that purpose. Lie bracket contributions and the non-linearity of the exponential map need to be taken into account in the sensitivity algorithms. Nevertheless, essential characteristics of formulations of the direct differentiation method and the adjoint variable method on linear spaces are recovered. Some implementation issues are discussed and two relevant examples illustrate the properties of these methods. [less ▲]

Detailed reference viewed: 67 (15 ULg)
Full Text
Peer Reviewed
See detailIsocinétisme : aspects spécifiques chez le sportif
Croisier, Jean-Louis ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Kinésithérapie Scientifique (2014), 550

Detailed reference viewed: 238 (49 ULg)
Full Text
Peer Reviewed
See detailDoes comfort therapy during controlled donation after circulatory death shorten the life of potential donors?
LEDOUX, Didier ULg; DELBOUILLE, Marie-Hélène ULg; DE ROOVER, Arnaud ULg et al

in Clinical transplantation (2014), 28(1), 47-51

INTRODUCTION: Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this ... [more ▼]

INTRODUCTION: Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this study was to determine whether this policy shortens the DCD donors' life. METHODS: The authors retrospectively analyzed prospectively collected data on patients proposed for DCD at the University Hospital of Liege, Belgium, over a 56-month period. The survival duration of these patients, defined as duration between the time of proposal for DCD and the time of circulatory arrest, was compared between patients who actually donated organs and those who did not. RESULTS: About 128 patients were considered for controlled DCD and 54 (43%) became donors. Among the 74 non-donor patients, 34 (46%) objected to organ donation, 38 patients (51%) were denied by the transplant team for various medical reasons, and two potential DCD donors did not undergo procurement due to logistical and organizational reasons. The survival durations were similar in the DCD donor and non-donor groups. No non-donor patient survived. CONCLUSIONS: Survival of DCD donors is not shortened when compared with non-donor patients. These data support the ethical and respectful approach to potential DCD donors in the authors' center, including regular comfort therapy. [less ▲]

Detailed reference viewed: 29 (5 ULg)
Full Text
Peer Reviewed
See detailGold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release
Liu, Ji ULg; Detrembleur, Christophe ULg; Grignard, Bruno ULg et al

in Chemistry : An Asian Journal (2014), 9(1), 275-288

Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)- light-sensitive gold-nanorod (GNR) core and a phase-changing poly(e-caprolactone)- b-poly(ethylene glycol ... [more ▼]

Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)- light-sensitive gold-nanorod (GNR) core and a phase-changing poly(e-caprolactone)- b-poly(ethylene glycol) polymer corona (GNR@PCL-b-PEG). The underlying mechanism of the drugloading and triggered-release behaviors involves the entrapment of drug payloads among the PCL crystallites and a heat-induced phase change, respectively. A low premature release of the pre-loaded doxorubicin was observed in PBS buffer (pH 7.4) at 37 °C (<10% of the entire payload after 48 h). However, release could be activated within 30 min by conventional heating at 50 °C, above the Tm of the crystalline PCL domain (43.5 °C), with about 60% release over the subsequent 42 h at 37 °C. The NIR-induced heating of an aqueous suspension of GNR@PCL-b- PEG under NIR irradiation (802 nm) was investigated in terms of the irradiation period, power, and concentrationdependent heating behavior, as well as the NIR-induced shape-transformation of the GNR cores. Remotely NIR-triggered release was also explored upon NIR irradiation for 30 min and about 70% release was achieved in the following 42 h at 37°C, with a mild warming (<4 °C) of the surroundings. The cytotoxicity of GNR@PCL-b-PEG against the mouse fibroblastic-like L929 cell-line was assessed by MTS assay and good compatibility was confirmed with a cell viability of over 90% after incubation for 72 h. The cellular uptake of GNR@PCL-b-PEG by melanoma MEL-5 cells was also confirmed, with an averaged uptake of 1250 ( ± 110) particles cell-1 after incubation for 12 h (50 mg mL-1). This GNR@PCL-b-PEG DDS is aimed at addressing the different requirements for therapeutic treatments and is envisaged to provide new insights into DDS targeting for remotely triggered release by NIR activation. [less ▲]

Detailed reference viewed: 26 (9 ULg)
Full Text
Peer Reviewed
See detailIntroduction d’approches socioconstructivistes dans le cours d’éducation physique. Avis des acteurs sur l’utilisation de fiches d’observation et du débat d’idées
Cloes, Marc ULg; Derome, Stéphane; Bonvoisin, Pierre-Henry

in e Journal de la Recherche sur l'Intervention en Éducation Physique et Sport (2014), 31

Two specific teaching approaches respecting the socioconstructivist principles (observation cards and students verbal exchanges) have been implemented in three secondary PE school classes during short ... [more ▼]

Two specific teaching approaches respecting the socioconstructivist principles (observation cards and students verbal exchanges) have been implemented in three secondary PE school classes during short teaching volleyball units. The study examines the opinions of the teachers and students about their experience. Both kind of actors were positively surprised by these original teaching approaches. PE teachers had some difficulties to share the leadership with their students but were impressed by the behavior of their students. The latter underlined that they appreciated to have the opportunity to learn by themselves. More resources should be developed to help the PE teachers to adopt such teaching approaches. [less ▲]

Detailed reference viewed: 43 (2 ULg)
Full Text
See detailQuantitative analysis using near infrared spectroscopy, application to tablet content uniformity test, II
Ginot, Y.-M.; Bernard-Moulin, P.; Boiret, M. et al

in STP Pharma Pratiques (2014), 24(1), 3-36

The first part of this article [1] described the methodology to follow to develop a technique for the quantitative analysis of active substance in a solid tablet type formulation using near infrared ... [more ▼]

The first part of this article [1] described the methodology to follow to develop a technique for the quantitative analysis of active substance in a solid tablet type formulation using near infrared spectroscopy. It seems appropriate to complete this description by detailing the different steps involved through illustrated examples and by proposing useful guidelines for new users. The quantitative analysis example chosen is that of content uniformity (CU) of tablet type solid forms (cf. Ph. Eur. 2.9.6/2.9.40) [2], a test required in the pharmaceutical industry and for which this alternative quantitative analysis could offer substantial gains. It should be noted that the approach described applies to other types of quantitative analysis (mean assay, water content in raw materials, polymorph assay within a tablet, etc.). [less ▲]

Detailed reference viewed: 45 (7 ULg)
Full Text
Peer Reviewed
See detailPas de culture de sécurité sans un leadership totalement convaincu, impliqué et moteur dans la démarche
COUCKE, Philippe ULg

in Healthcare Executive (2014)

La culture de sécurité en santé publique a 40 ans de retard Le rapport de l’IOM (Institute of Medicine), publié en 1999, met le doigt sur les risques auxquels les patients s’exposent en rentrant dans un ... [more ▼]

La culture de sécurité en santé publique a 40 ans de retard Le rapport de l’IOM (Institute of Medicine), publié en 1999, met le doigt sur les risques auxquels les patients s’exposent en rentrant dans un secteur hospitalier. Ces nombres éloquents ne sont pas l’apanage d’un système de santé publique particulier, par ailleurs fortement décrié et propre aux Etats Unis d’Amérique. Les statistiques dans d’autres systèmes de santé sont identiques et l’OMS clame aujourd’hui que, lorsque vous êtes admis dans un hôpital, vous avez 10% de risque d’en sortir moins bien qu’à l’entrée (European Union Network for Patient Safety). Et pourtant, tous les acteurs du terrain se gargarisent avec le slogan «priorité à la sécurité». Malheureusement, il s’agit là souvent simplement d’un slogan qui ne se reflète pas dans nos pratiques journalières. Et c’est là que le secteur de la santé se différencie singulièrement des autres domaines d’activités industrielles dits à haut risque (aviation civile, centrales atomiques, industrie alimentaire), qui ont depuis longue date un «management du risque opérationnel» organisé, structuré et prospectif. Un des principes de base du management du risque est la mesure: dans les écoles managériales on apprend que l’on ne peut manager ce que l’on ne mesure pas. Mesurons-nous les risques en santé publique? Avons-nous des indicateurs fiables, reproductibles, transparents qui nous donnent une idée de la sécurité et de la qualité de nos pratiques? L’incidence des risques systémiques – et je préfère utiliser ce terme plutôt que celui d’«erreur médicale» – est certainement sous-estimée, car il n’y pas en santé publique une culture de sécurité qui prône la déclaration spontanée et transparente de tous les événements, qu’ils soient indésirables (sans effet délétère pour le patient) ou greffés d’effet mineur (incident) ou majeur (accident). [less ▲]

Detailed reference viewed: 80 (8 ULg)
Full Text
Peer Reviewed
See detailWhere are the politics in responsible innovation? European governance, technology assessments, and beyond
Van Oudheusden, Michiel ULg

in Journal of Responsible Innovation (2014), 1(1), 67-86

Responsible innovation (RI) is founded on the idea that present modes of innovating with science and technology fail because they insufficiently take into account societal needs and values. Hence ... [more ▼]

Responsible innovation (RI) is founded on the idea that present modes of innovating with science and technology fail because they insufficiently take into account societal needs and values. Hence, proponents of RI solicit society's opinions in an attempt to render science and technology developments, institutions, and policies more socially responsive. This article asks how the RI concept is taken up and elaborated, based on accounts developed on the EU policy level and on a Flemish, technology assessment level. It finds that, notwithstanding important differences between these two deliberative frameworks, neither one leaves much room for politics, understood as the constitution and contestation of power. Rather, these frameworks largely ignore questions about the politics in and of deliberation, the authoritative allocation of values, and the institutional uptake of deliberative engagements. The article's aim is to provide constructive criticism of the RI paradigm by rendering these political issues explicit and proposing ways of taking them into account. [less ▲]

Detailed reference viewed: 30 (3 ULg)
Full Text
Peer Reviewed
See detailDe quoi sont faits les systèmes sémiotiques
Badir, Sémir ULg

in Actes Sémiotiques (2014), 117

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailRemote ischaemic pre-conditioning in cardiac surgery: benefit or not?
Kolh, Philippe ULg

in European heart journal (2014), 35(3), 141-3

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailScreening for malnutrition in lung cancer patients undergoing therapy
BARTHELEMY, Nicole ULg; Streel, Sylvie ULg; Donneau, Anne-Françoise ULg et al

in Supportive Care in Cancer (2014), 22(6), 15311536

Detailed reference viewed: 31 (14 ULg)
Full Text
Peer Reviewed
See detailRessources naturelles, matières premières et géographie. L'exemple des ressources énergétiques et minières
Deshaies, Michel; Merenne-Schoumaker, Bernadette ULg

in BSGLg (2014), 62

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has ... [more ▼]

Natural resources, including mineral and energy resources are increasingly the subject of geographical works. To understand this renewal, the authors first seek to show how the geography of resources has evolved over time and then analyze new research issues that emerge from a decade. Through this brief analysis, everything indicates a real expansion of fields of investigation, undoubtedly related to the new challenges and opportunities posed by resources that go far beyond the traditional field of economic geography. [less ▲]

Detailed reference viewed: 35 (0 ULg)
Full Text
Peer Reviewed
See detailPhosphine- and ammonium-functionalized ordered mesoporous carbons as supports for cluster-derived metal nanoparticles
Vidick, Deborah; Léonard, Alexandre ULg; Poleunis, Claude et al

in Catalysis Today (2014), 235

An ordered mesoporous carbon (OMC) was functionalized with ammonium or chelating phosphine ligands. In both cases, the functionalization procedure started by oxidation by nitric acid treatment, followed ... [more ▼]

An ordered mesoporous carbon (OMC) was functionalized with ammonium or chelating phosphine ligands. In both cases, the functionalization procedure started by oxidation by nitric acid treatment, followed by activation of surface carboxylic acid groups with thionyl chloride, then formation of amide bonds with diamines. The pendant amine groups were then either quaternized or further reacted with phosphine. The introduced functions were used as anchors for molecular mixed-metal clusters. These organometallic grafted species could then be thermally transformed into hetero-metallic nanoparticles (NP) embedded within the mesoporous framework. The NP/OMC nanocomposites could find application in hydrogenation, heterogeneous catalysis or as electrodes in fuel cells. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailEclipsing Am binary systems in the SuperWASP survey
Smalley, B.; Southworth, J.; Pintado, O. I. et al

in Astronomy and Astrophysics (2014), 564

The results of a search for eclipsing Am star binaries using photometry from the SuperWASP survey are presented. The light curves of 1742 Am stars fainter than V = 8.0 were analysed for the presence of ... [more ▼]

The results of a search for eclipsing Am star binaries using photometry from the SuperWASP survey are presented. The light curves of 1742 Am stars fainter than V = 8.0 were analysed for the presence of eclipses. A total of 70 stars were found to exhibit eclipses, with 66 having sufficient observations to enable orbital periods to be determined and 28 of which are newly identified eclipsing systems. Also presented are spectroscopic orbits for 5 of the systems. The number of systems and the period distribution is found to be consistent with that identified in previous radial velocity surveys of "classical" Am stars. [less ▲]

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailIron sucrose - characteristics, efficacy and regulatory aspects of an established treatment of iron deficiency and iron-deficiency anemia in a broad range of therapeutic areas
JASPERS, Aurélie ULg; Beguin, Yves ULg

in Expert Opinion on Pharmacotherapy (2014), 15

Introduction: Iron is a key element in the transport and utilization of oxygen and a variety of metabolic pathways. Iron deficiency is a major cause of anemia and can be associated with fatigue, impaired ... [more ▼]

Introduction: Iron is a key element in the transport and utilization of oxygen and a variety of metabolic pathways. Iron deficiency is a major cause of anemia and can be associated with fatigue, impaired physical function and reduced quality of life. Administration of oral or intravenous (i.v.) iron is the recommended treatment for iron-deficiency anemia (IDA) in different therapeutic areas. Areas covered: This article provides an overview of studies that evaluated i.v. iron sucrose for anemia and iron status management, either alone or in combination with erythropoiesis-stimulating agents, across various diseases and conditions. Expert opinion: Iron sucrose is an established, effective and well-tolerated treatment of IDA in patients with acute or chronic conditions such as chronic kidney disease, inflammatory bowel disease, pregnancy (second and third trimester), postpartum period, heavy menstrual bleeding and cancer who need rapid iron supply and in whom oral iron preparations are ineffective or not tolerated. Available data on patient blood management warrant further studies on preoperative iron treatment. First experience with iron sucrose follow-on products raises questions about their therapeutic equivalence without comparative clinical data in newly diagnosed patients or patients on existing chronic treatment. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailModulating effect of COMT genotype on the brain regions underlying proactive control process during inhibition
Jaspar, Mathieu ULg; Genon, Sarah ULg; Muto, Vincenzo ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 50

Introduction. Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions ... [more ▼]

Introduction. Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to three groups of 15 young adults according to their COMT Val158Met genotype [Val/Val (VV), Val/Met (VM) and Met/Met (MM)]. Based on the theory of dual mechanisms of control (Braver, et al., 2007), the Stroop task has been built to induce proactive or reactive control processes according to the task context. Results. Behavioral results did not show any significant group differences for reaction times but Val allele carriers individuals are less accurate in the processing of incongruent items. fMRI results revealed that proactive control is specifically associated with increased activity in the anterior cingulate cortex (ACC) in carriers of the Met allele, while increased activity is observed in the middle frontal gyrus (MFG) in carriers of the Val allele. Conclusion. These observations, in keeping with a higher cortical dopamine level in MM individuals, support the hypothesis of a COMT Val158Met genotype modulation of the brain regions underlying proactive control, especially in frontal areas as suggested by Braver et al. [less ▲]

Detailed reference viewed: 70 (23 ULg)
Full Text
Peer Reviewed
See detailAssessing the potential of an algorithm based on mean climatic data to predict wheat yield
Dumont, Benjamin ULg; Leemans, Vincent ULg; Ferrandis, Salvador et al

in Precision Agriculture (2014)

The real-time non-invasive determination of crop biomass and yield prediction is one of the major challenges in agriculture. An interesting approach lies in using process-based crop yield models in ... [more ▼]

The real-time non-invasive determination of crop biomass and yield prediction is one of the major challenges in agriculture. An interesting approach lies in using process-based crop yield models in combination with real-time monitoring of the input climatic data of these models, but unknown future weather remains the main obstacle to reliable yield prediction. Since accurate weather forecasts can be made only a short time in advance, much information can be derived from analyzing past weather data. This paper presents a methodology that addresses the problem of unknown future weather by using a daily mean climatic database, based exclusively on available past measurements. It involves building climate matrix ensembles, combining different time ranges of projected mean climate data and real measured weather data originating from the historical database or from real-time measurements performed in the field. Used as an input for the STICS crop model, the datasets thus computed were used to perform statistical within-season biomass and yield prediction. This work demonstrated that a reliable predictive delay of 3-4 weeks could be obtained. In combination with a local micrometeorological station that monitors climate data in real-time, the approach also enabled us to (i) predict potential yield at the local level, (ii) detect stress occurrence and (iii) quantify yield loss (or gain) drawing on real monitored climatic conditions of the previous few days. [less ▲]

Detailed reference viewed: 60 (31 ULg)
Full Text
Peer Reviewed
See detailDeterminants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.
Voilliot, Damien; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014)

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the ... [more ▼]

BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. METHODS AND RESULTS: We prospectively enrolled 63 patients with SSc (age 54+/-3years, 76% female) followed in CHU Sart-Tilman in Liege. All patients underwent graded semi-supine exercise echocardiography. Systolic pulmonary arterial pressure (sPAP) was derived from the peak velocity of the tricuspid regurgitation jet and adding the estimation of right atrial pressure, both at rest and during exercise. Resting pulmonary arterial hypertension (PH) was defined as sPAP >35mmHg and EIPH as sPAP >50mmHg during exercise. The following formulas were used: mean PAP (mPAP)=0.61xsPAP+2, left atrial pressure (LAP)=1.9+1.24xleft ventricular (LV) E/e' and pulmonary vascular resistance (PVR)=(mPAP-LAP)/LV cardiac output (CO) and slope of mPAP-LVCO relationship=changes in mPAP/changes in LVCO. Resting PH was present in 3 patients (7%) and 21 patients developed EIPH (47%). Patients with EIPH had higher resting LAP (10.3+/-2.2 versus 8.8+/-2.3mmHg; p=0.03), resting PVR (2.6+/-0.8 vs. 1.4+/-1.1Woods units; p=0.004), exercise LAP (13.3+/-2.3 vs. 9+/-1.7mmHg; p<0.0001), exercise PVR (3.6+/-0.7 vs. 2.1+/-0.9 Woods units; p=0.02) and slope of mPAP-LVCO (5.8+/-2.4 vs. 2.9+/-2.1mmHg/L/min; p<0.0001). After adjustment for age and gender, exercise LAP (beta=3.1+/-0.8; p=0.001) and exercise PVR (beta=7.9+/-1.7; p=0.0001) were independent determinants of exercise sPAP. CONCLUSION: EIPH is frequent in SSc patients and is mainly related to both increased exercise LV filling pressure and exercise PVR. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailLes sons de contact de l'ombrine côtière - Umbrina cirrosa (Linné, 1758)
Lagardère, Jean-Paul; Parmentier, Eric ULg

in Bulletin de la Société de Borda (2014), 514

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailInfluences of proline and cysteine residues on fragment yield in matrix-assisted laser desorption/ionization in-source decay mass spectrometry
Asakawa, Daiki; Smargiasso, Nicolas ULg; Quinton, Loïc ULg et al

in Journal of the American Society for Mass Spectrometry (2014)

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailLes vergetures, leurs couleurs et leur mécanobiologie.
FRANCHIMONT, Claudine ULg; Peters, S.; Hermanns, J.F. et al

in Revue Médicale de Liège (2014), 69

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailExercise testing in asymptomatic severe aortic stenosis.
Magne, Julien ULg; Lancellotti, Patrizio ULg; Pierard, Luc ULg

in JACC. Cardiovascular imaging (2014), 7(2), 188-99

The management and the clinical decision making in asymptomatic patients with aortic stenosis are challenging. An "aggressive" management, including early aortic valve replacement, is debated in these ... [more ▼]

The management and the clinical decision making in asymptomatic patients with aortic stenosis are challenging. An "aggressive" management, including early aortic valve replacement, is debated in these patients. However, the optimal timing for surgery remains controversial due to the lack of prospective data on the determinants of aortic stenosis progression, multicenter studies on risk stratification, and randomized studies on patient management. Exercise stress testing with or without imaging is strictly contraindicated in symptomatic patients with severe aortic stenosis. Exercise stress test is now recommended by current guidelines in asymptomatic patients and may provide incremental prognostic value. Indeed, the development of symptoms during exercise or an abnormal blood pressure response are associated with poor outcome and should be considered as an indication for surgery, as suggested by the most recently updated European Society of Cardiology 2012 guidelines. Exercise stress echocardiography may also improve the risk stratification and identify asymptomatic patients at higher risk of a cardiac event. When the test is combined with imaging, echocardiography during exercise should be recommended rather than post-exercise echocardiography. During exercise, an increase >18 to 20 mm Hg in mean pressure gradient, absence of improvement in left ventricular ejection fraction (i.e., absence of contractile reserve), and/or a systolic pulmonary arterial pressure >60 mm Hg (i.e., exercise pulmonary hypertension) are suggestive signs of advanced stages of the disease and impaired prognosis. Hence, exercise stress test may identify resting asymptomatic patients who develop exercise abnormalities and in whom surgery is recommended according to current guidelines. Exercise stress echocardiography may further unmask a subset of asymptomatic patients (i.e., without exercise stress test abnormalities) who are at high risk of reduced cardiac event free survival. In these patients, early surgery could be beneficial, whereas regular follow-up seems more appropriate in patients without echocardiographic abnormalities during exercise. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailRecommandations europeennes concernant la therapie de resynchronisation cardiaque.
ROBINET, Sébastien ULg; DELCOUR, Alexandre ULg; Lancellotti, Patrizio ULg

in Revue medicale de Liege (2014), 69(4), 180-7

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In ... [more ▼]

Cardiac resynchronization therapy (CRT) is one of the most successful heart failure therapies to emerge in the last 25 years; it is applicable to > 25-30% of patients with symptomatic heart failure. In this article, we summarize the recommendations of the European Society of Cardiology of 2013 on cardiac resynchronization therapy. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailCervical cancer and HPV: Awareness and vaccine acceptability among parents in Morocco.
Mouallif, Mustapha; Bowyer, Harriet L.; Festali, Soukaina et al

in Vaccine (2014), 32(3), 409-16

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since ... [more ▼]

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since 2008 but there are no available data on their acceptability. This study aimed to assess awareness of HPV and the vaccine, and to identify factors associated with acceptability of the vaccine among parents in Morocco. We carried out a questionnaire-based survey using face-to-face interviews in a sample of 852 parents (670 mothers and 182 fathers) with at least one unmarried daughter </=26 years. We collected data within public and private health centres and clinics in four regions in Morocco between July and August 2012. The main outcome measure was parental acceptability of the HPV vaccine for their daughter(s). Responses revealed very low awareness of HPV infection (4.7%) and the HPV vaccine (14.3%). None of the participants had vaccinated their daughter(s) against HPV and vaccine acceptability was low among mothers (32%) and fathers (45%). Higher education and income, previous awareness of the HPV vaccine and endorsement of the belief that a recommendation from the Ministry of Health or a doctor to have the vaccine would be encouraging, were associated with mothers' HPV vaccine acceptability. Non-acceptability among mothers was associated with having more than two daughters, believing the vaccine was expensive, lack of information and believing that whatever happens to an individual's health is God's will. The only factor associated with the fathers' acceptability of the vaccine was the cost of the vaccine. Increasing HPV and HPV vaccine awareness through educational campaigns, along with active recommendation by physicians and a publically funded vaccination programme could increase parental acceptability of the HPV vaccine in Morocco. [less ▲]

Detailed reference viewed: 29 (2 ULg)
Full Text
Peer Reviewed
See detailCell invasion in the spheroid sprouting assay: a spatial organisation analysis adaptable to cell behaviour.
Blacher, Silvia ULg; Erpicum, Charlotte ULg; Lenoir, Benedicte et al

in PLoS ONE (2014), 9(5), 97019

The endothelial cell spheroid assay provides a suitable in vitro model to study (lymph) angiogenesis and test pro- and anti-(lymph) angiogenic factors or drugs. Usually, the extent of cell invasion ... [more ▼]

The endothelial cell spheroid assay provides a suitable in vitro model to study (lymph) angiogenesis and test pro- and anti-(lymph) angiogenic factors or drugs. Usually, the extent of cell invasion, observed through optical microscopy, is measured. The present study proposes the spatial distribution of migrated cells as a new descriptor of the (lymph) angiogenic response. The utility of this novel method rests with its capacity to locally characterise spheroid structure, allowing not only the investigation of single and collective cell invasion but also the evolution of the spheroid core itself. Moreover, the proposed method can be applied to 2D-projected spheroid images obtained by optical microscopy, as well as to 3D images acquired by confocal microscopy. To validate the proposed methodology, endothelial cell invasion was evaluated under different experimental conditions. The results were compared with widely used global parameters. The comparison shows that our method prevents local spheroid modifications from being overlooked and leading to the possible misinterpretation of results. [less ▲]

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailBlocking lipid synthesis overcomes tumor re-growth and metastasis after anti-angiogenic therapy withdrawal.
Sounni, Nor Eddine ULg; Cimino, Jonathan ULg; BLACHER, Silvia ULg et al

in Cell Metabolism (2014), 20(2), 280-94

The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied transcriptomic, proteomic, and metabolomic approaches ... [more ▼]

The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied transcriptomic, proteomic, and metabolomic approaches to preclinical models and provide evidence for tumor adaptation to vascular endothelial growth factor blockade through a metabolic shift toward carbohydrate and lipid metabolism in tumors. During sunitinib or sorafenib treatment, tumor growth was inhibited and tumors were hypoxic and glycolytic. In sharp contrast, treatment withdrawal led to tumor regrowth, angiogenesis restoration, moderate lactate production, and enhanced lipid synthesis. This metabolic shift was associated with a drastic increase in metastatic dissemination. Interestingly, pharmacological lipogenesis inhibition with orlistat or fatty acid synthase downregulation with shRNA inhibited tumor regrowth and metastases after sunitinib treatment withdrawal. Our data shed light on metabolic alterations that result in cancer adaptation to antiangiogenic treatments and identify key molecules involved in lipid metabolism as putative therapeutic targets. [less ▲]

Detailed reference viewed: 60 (26 ULg)
Full Text
Peer Reviewed
See detailBrentano's "Descriptive" Realism
Seron, Denis ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(4), 1-14

Brentano’s metaphysical position in Psychology from an Empirical Standpoint is usually assumed to be metaphysical realism. I propose an alternative interpretation, according to which Brentano was at that ... [more ▼]

Brentano’s metaphysical position in Psychology from an Empirical Standpoint is usually assumed to be metaphysical realism. I propose an alternative interpretation, according to which Brentano was at that time, as well as later, a full-fledged phenomenalist. However, his phenomenalism is markedly different from standard phenomenalism in that it does not deny that the physicist’s judgments are really about the objective world. The aim of the theory of intentionality, I argue, is to allow for extra-phenomenal aboutness within a phenomenalist framework. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
See detailQuestions de méthodes. Sartre, Giovannangeli, la phénoménologie et les "structuralistes"
Cormann, Grégory ULg

in Bulletin d'Analyse Phénoménologique (2014), 10(11), 74-88

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailRegenerative orthopaedics: in vitro, in vivo ... in silico.
Geris, Liesbet ULg

in International orthopaedics (2014), 38(9), 1771-8

In silico, defined in analogy to in vitro and in vivo as those studies that are performed on a computer, is an essential step in problem-solving and product development in classical engineering fields ... [more ▼]

In silico, defined in analogy to in vitro and in vivo as those studies that are performed on a computer, is an essential step in problem-solving and product development in classical engineering fields. The use of in silico models is now slowly easing its way into medicine. In silico models are already used in orthopaedics for the planning of complicated surgeries, personalised implant design and the analysis of gait measurements. However, these in silico models often lack the simulation of the response of the biological system over time. In silico models focusing on the response of the biological systems are in full development. This review starts with an introduction into in silico models of orthopaedic processes. Special attention is paid to the classification of models according to their spatiotemporal scale (gene/protein to population) and the information they were built on (data vs hypotheses). Subsequently, the review focuses on the in silico models used in regenerative orthopaedics research. Contributions of in silico models to an enhanced understanding and optimisation of four key elements-cells, carriers, culture and clinics-are illustrated. Finally, a number of challenges are identified, related to the computational aspects but also to the integration of in silico tools into clinical practice. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailExciton dissociation at donor-acceptor heterojunctions: Dynamics using the collective effective mode representation of the spin-boson model
Chenel, Aurélie; Mangaud, Etienne; Burghardt, Irène et al

in Journal of Chemical Physics (2014), 140

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailBrain natriuretic peptide release in patients with aortic stenosis: Resting and exercise echocardiographic determinants.
Henri, Christine; Magne, Julien ULg; Dulgheru, Raluca et al

in International journal of cardiology (2014), 172(3), 611-3

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailIncrease in dimethylsulfide (DMS) emissions due to eutrophication of coastal waters offsets their reduction due to ocean acidification
Gypens, N; Borges, Alberto ULg

in Frontiers in Marine Science - Marine Ecosystem Ecology (2014), 1(4),

Available information from manipulative experiments suggested that the emission of dimethylsulfide (DMS) would decrease in response to the accumulation of anthropogenic CO2 in the ocean (ocean ... [more ▼]

Available information from manipulative experiments suggested that the emission of dimethylsulfide (DMS) would decrease in response to the accumulation of anthropogenic CO2 in the ocean (ocean acidification). However, in coastal environments, the carbonate chemistry of surface waters was also strongly modified by eutrophication and related changes in biological activity (increased primary production and change in phytoplankton dominance) during the last 50 years. Here, we tested the hypothesis that DMS emissions in marine coastal environments also strongly responded to eutrophication in addition to ocean acidification at decadal timescales. We used the R-MIRO-BIOGAS model in the eutrophied Southern Bight of the North Sea characterized by intense blooms of Phaeocystis that are high producers of dimethylsulfoniopropionate (DMSP), the precursor of DMS. We showed that, for the period from 1951 to 2007, eutrophication actually led to an increase of DMS emissions much stronger than the response of DMS emissions to ocean acidification. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailContinuity amid change in India’s political economy: from “socialist” to “neoliberal” India.
Maiorano, Diego ULg

in Economic and Political Weekly (2014)

The aim of this paper is to show that the social coalition that benefited from India’s central government’s economic policies remained unchanged between the pre and post economic reforms periods. More ... [more ▼]

The aim of this paper is to show that the social coalition that benefited from India’s central government’s economic policies remained unchanged between the pre and post economic reforms periods. More specifically, this paper will argue that the economic policies promoted by the central government between 1980 and 2004 – irrespective of the political party heading the Cabinet – mostly benefited the middle class and the corporate sector, while the poor and the rural world were clearly relegated to a secondary position in the governments’ policy priorities. The paper will highlight six important lines of continuity in India’s economic policy and will argue that if we look at who the “winner” and the “losers” of these policy processes are, the economic reforms of the early 1990s do not separate two different phases of India’s development path. From this point of view the election of the United Progressive Alliance (UPA) government in 2004 might constitute a more important break with the past. [less ▲]

Detailed reference viewed: 54 (1 ULg)
Full Text
Peer Reviewed
See detailGenetic analysis of pig survival up to commercial weight in a crossbred population
Dufrasne, Marie ULg; Misztal, Ignacy; Tsuruta, Shogo et al

in Livestock Science (2014), 167

Records from 99,384 crossbred pigs from Duroc sires and Large White x Landrace dams were used to estimate genetic parameters for survival traits at different stages of the fattening period, and their ... [more ▼]

Records from 99,384 crossbred pigs from Duroc sires and Large White x Landrace dams were used to estimate genetic parameters for survival traits at different stages of the fattening period, and their relations with final weight. Traits analyzed were preweaning mortality (PWM), culling between weaning and harvesting (Call), culling during the farrowing period (Cfar), in the nursery site (Cnur), during the finishing phase (Cfin), and hot carcass weight (HCW). Because of the binary nature of PWM and culling traits, threshold-linear models were used: Model 1, including PWM, Call, and HCW; Model 2, including PWM, Cfar, Cnur, Cfin, and HCW. Both models included sex and parity number as fixed effects for all traits. Contemporary groups were considered as fixed effect for HCW and as random effects for the binary traits. Random effects were sire additive genetic, common litter, and residual effects for all traits and models. Heritability estimates were 0.03 for PWM, and 0.15 for HCW with both models, 0.06 for Call with Model 1, and 0.06 for Cfar, 0.14 for Cnur, and 0.10 for Cfin with Model 2. Litter variance explained a large part of the total variance and its influence declined slightly with age. For Model 1, genetic correlations were -0.36 between PWM and Call, -0.02 between PWM and HCW, and -0.25 between Call and HCW; correlations for litter effect were -0.15 between PWM and Call, -0.19 between PWM and HCW, and -0.21 between Call and HCW. For Model 2, genetic correlations were all positive between PWM and culling traits, except between PWM and Cnur (-0.61). Genetic correlations between HCW and the other traits were moderate and negative to null. Correlations for common litter effect were all negative between traits, except between Cfar and Cfin, and between Cnur and Cfin. Heritability of PWM and culling traits increased with age period. Therefore, selection for survival after weaning may be more efficient. The low genetic correlations between PWM and culling traits suggest that different genes influence pre- and postweaning mortality. The HCW was not correlated with the other traits. However, relationships are not strongly unfavorable, therefore selection for survival and high final weight is possible. [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailEffects of glucose-lowering agents on vascular outcomes in type 2 diabetes: A critical reappraisal.
Scheen, André ULg; Charbonnel, B.

in Diabetes & metabolism (2014)

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major ... [more ▼]

Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain how hyperglycaemia induces vascular damage. However, randomized controlled trials investigating either an intensive glucose-lowering strategy vs standard care or the addition of a new glucose-lowering agent vs a placebo have largely failed to demonstrate any clinical benefits in terms of cardiovascular morbidity or mortality. This lack of evidence has led some people to contest the clinical efficacy of lowering blood glucose in patients with T2DM, despite its positive effects on microvascular complications. This article analyzes the various reasons that might explain such discrepancies. There are still strong arguments in favour of targeting hyperglycaemia while avoiding other counterproductive effects, such as hypoglycaemia and weight gain, and of integrating the glucose-lowering approach within a global multi-risk strategy to reduce the burden of cardiovascular disease in T2DM. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailUn complexe d’espèces d’Afzelia des forêts africaines d’intérêt économique et écologique (synthèse bibliographique)
Donkpegan, Segbedji ULg; Hardy, J. Olivier; Lejeune, Philippe ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(2),

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The ... [more ▼]

The purpose of this review is to provide a knowledge update and a comprehensive literature review of the genus Afzelia, a complex of sister species exploited for their timber in Central Africa. The distribution of Afzelia species in Africa suggests that the tree has made various adaptations due to ecological factors. However, on the basis of only vegetative criteria, it is difficult to distinguish species in forest inventory, and this could compromise the sustainable management approach promoted by the populations of Central African countries. We show that the genus remains generally understudied, although some of its species are considered by the IUCN as being under threat. Therefore, the ecological and genetic aspects of our investigations should prove relevant to the future cultivation of Afzelia. [less ▲]

Detailed reference viewed: 25 (4 ULg)
Full Text
Peer Reviewed
See detailEffect of the kinematic hardening in the simulations of the straightening of long rolled profiles
Bouffioux, Chantal ULg; Boman, Romain ULg; Caillet, Nicolas et al

in Key Engineering Materials [=KEM] (2014), 611-612

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are ... [more ▼]

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are straightened using a series of rollers placed alternately above and below the pieces with shifts which create a succession of bendings. The process is modeled to study the impact of the industrial parameters ( the duration of the cooling and the rollers positions), to improve the final geometry and to reduce the residual stresses.Tests are carried out on this structural steel to observe the material behavior, then material laws are chosen and parameters of these laws are defined using and inverse method. Two sets of material data are obtained: for the first one, the hardening is supposed to be isotropic, and for the second one, additional tests are performed to describe isotropic and kinematic hardenings.The cooling followed by the straightening is then simulated by the finite element with these two sets of date. The comparison of the rollers forces, the deformation and the residual stresses show the impact of the kinematic hardening on such a process where the material undergoes a sucession of the tensions and compressions. The real forces applied by the rollers,the real curvature of the interlocks at the end of the straightening process and the distribution of the residual longitudinal stresses measured on the web using the ring core method are used to validate the numerical model. [less ▲]

Detailed reference viewed: 17 (8 ULg)
Full Text
Peer Reviewed
See detailSimulation-based study comparing multiple imputation methods for non-monotone missing ordinal data in longitudinal settings
Donneau, Anne-Françoise ULg; Mauer, Murielle; Lambert, Philippe ULg et al

in Journal of Biopharmaceutical Statistics (2014)

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the ... [more ▼]

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the joint modeling and the fully conditional specification approaches. Their relative performance for the longitudinal ordinal data setting under the missing at random (MAR) assumption is not well documented. This paper intends to fill this gap by conducting a large simulation study on the estimation of the parameters of a longitudinal proportional odds model. The two MI methods are also illustrated in quality of life data from a cancer clinical trial. [less ▲]

Detailed reference viewed: 62 (16 ULg)
Full Text
See detailBulletin bibliographique de la Société Rencesvals 2013-2014
Henrard, Nadine ULg

in Bulletin Bibliographique de la Société Rencesvals (2014), 45

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailComparison of two FFPE preparation methods using label-free shotgun proteomics: Application to tissues of diverticulitis patients.
Quesada-Calvo, Florence; Bertrand, Virginie ULg; Longuespée, Rémi ULg et al

in Journal of proteomics (2014), 112C

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic ... [more ▼]

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic biomarkers. However, the critical step in this field is the ability to obtain an efficient and repeatable extraction using the limited quantities of material available for research in hospital biobanks. This work describes the evaluation of the peptide/protein extraction using FFPE sections treated by the following two methods before shotgun proteomic analysis: a commercial solution (FFPE-FASP) (filter aided sample preparation) and an antigen retrieval-derived protocol (On Slice AR). Their efficiencies and repeatabilities are compared using data-independent differential quantitative label-free analysis. FFPE-FASP was shown to be globally better both qualitatively and quantitatively than On Slice AR. FFPE-FASP was tested on several samples, and differential analysis was used to compare the tissues of diverticulitis patients (healthy and inflammatory tissues). In this differential proteomic analysis using retrospective clinical FFPE material, FFPE-FASP was reproducible and provided a high number of confident protein identifications, highlighting potential protein biomarkers. BIOLOGICAL SIGNIFICANCE: In clinical proteomics, FFPE is an important resource for retrospective analysis and for the discovery of biomarkers. The challenge for FFPE shotgun proteomic analysis is preparation by an efficient and reproducible protocol, which includes protein extraction and digestion. In this study, we analyzed two different methods and evaluated their repeatabilities and efficiencies. We illustrated the reproducibility of the most efficient method, FFPE-FASP, by a pilot study on diverticulitis tissue and on FFPE samples amount accessible in hospital biobanks. These data showed that FFPE is suitable for use in clinical proteomics, especially when the FFPE-FASP method is combined with label-free shotgun proteomics as described in the workflow presented in this work. [less ▲]

Detailed reference viewed: 39 (7 ULg)
Full Text
Peer Reviewed
See detailCharacterization of Black locust (Robinia pseudoacacia L.) heartwood extractives: identification of resveratrol and piceatannol
Sergent, Thérèse; Kohnen, Stéphane; Jourez, Benoît ULg et al

in Wood Science and technology (2014)

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less ... [more ▼]

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less durability against fungi decay, which could be attributed to lower extractive content. In order to elucidate this idea, extractives from mature and juvenile heartwoods of black locust trees were investigated. Results showed that extractive and phenolic contents were higher in mature than in juvenile heartwoods. The identification of phenolic compounds by UPLC–DAD–MS/MS revealed, for the first time, the presence of resveratrol and piceatannol. These two stilbenes as well as the flavonoid dihydrorobinetin were present at the highest level in mature heartwood, and as they are known antifungals, they could account for the great durability of mature heartwood. The stilbenes were detected in significant amounts particularly in mature heartwood where piceatannol reached a level tenfold higher than that reported for Japanese knotweed roots, the primary natural source of these stilbenes, whereas resveratrol level was comparable with reported values. As resveratrol and piceatannol receive increasing demand for nutraceutical, cosmetic and, possibly, pharmaceutical purposes, due to their beneficial health effects, this study underlines the use of R. pseudoacacia as a promising sustainable and economical source of resveratrol and piceatannol. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailAssociative learning of Nasonia vitripennis Walker (Hymenoptera: Pteromalidae) to methyldisulfanylmethane
Frederickx, Christine ULg; Verheggen, François ULg; Brostaux, Yves ULg et al

in Journal of Forensic Sciences (2014)

Traditional methods of volatile detection used by police typically consist of reliance on canine olfaction. However, dogs have some limitations such as cost of training and time of conditioning. The ... [more ▼]

Traditional methods of volatile detection used by police typically consist of reliance on canine olfaction. However, dogs have some limitations such as cost of training and time of conditioning. The possibility of using parasitic wasps for detecting explosives and narcotics has been developed. Moreover, wasps are cheap to produce and can be conditioned with impressive speed for a specific chemical-detection task. We examined the ability of Nasonia vitripennis Walker to learn and respond to methydisulfanylmethane (DMDS), a volatile discriminator of cadaver. The training aimed to form an association between an unconditioned stimulus (pupae) and the conditioned stimulus (odor source). After the training, the time spent of conditioned wasps in the DMDS chamber was measured. Statistical analysis showed that the increasing concentrations involved an increase in the time spent in the chamber containing DMDS. This study indicates that N. vitripennis can respond to DMDS, which provide further support for its development as a biological sensor. [less ▲]

Detailed reference viewed: 62 (6 ULg)
Full Text
Peer Reviewed
See detailEcosystem services of mixed species forest stands and monocultures: comparing practitioners' and scientists' perceptions with formal scientific knowledge
Carnol, Monique ULg; Baeten, Lander; Branquart, Etienne et al

in Forestry (2014)

Mixed species stands might contribute to important goals of sustainable forest management, such as higher biological diversity, more resistance and resilience to disturbances and higher carbon storage ... [more ▼]

Mixed species stands might contribute to important goals of sustainable forest management, such as higher biological diversity, more resistance and resilience to disturbances and higher carbon storage. Knowledge of stakeholders' perceptions of such ecosystem services in mixed species stands is required for effective policy development. We showed that practitioners' and scientists' perceptions of ecosystem services in mixed species stands in Belgium differed from formal scientific knowledge derived from a synthesis of published studies. The positive perception of supporting, regulating and cultural services in mixed species stands contrasted with less conclusive results from the literature, where positive, negative and neutral effects were reported. Many respondents also signified a lack of information about regulating services. Furthermore, provisioning services were perceived as equal in mixed species stands and monocultures, in contrast to higher productivity demonstrated in mixed species stands in the literature. The regional (Flanders and Wallonia) ecological and socio-economic context influenced both the perception of ecosystem services and of the importance of management objectives. Our results highlighted the need to address the lack of scientific data, to adapt communication to the ecological and socio-economic context, as well as to improve information flow on regulating services and productivity. [less ▲]

Detailed reference viewed: 26 (6 ULg)
Full Text
Peer Reviewed
See detailValidation of an extended French version of ID MigraineTM as a migraine-screening tool
Streel, Sylvie ULg; Donneau, Anne-Françoise ULg; Dardenne, Nadia ULg et al

in Cephalalgia : An International Journal of Headache (2014)

Detailed reference viewed: 19 (11 ULg)
Full Text
Peer Reviewed
See detailAssessment of Solvent Degradation within a Global Process Model of Post-Combustion CO2 Capture
Léonard, Grégoire ULg; Toye, Dominique ULg; Heyen, Georges ULg

in Computer Aided Chemical Engineering (2014), 33

Solvent degradation may be a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. However, its influence on the ... [more ▼]

Solvent degradation may be a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. However, its influence on the process operations has rarely been studied. In the present work, a kinetics model describing solvent oxidative and thermal degradation has been developed based on own experimental results for the benchmark solvent, i.e. 30 wt% monoethanolamine (MEA) in water. This model has been included into a global Aspen Plus model of the CO2 capture process. The selected process modelling approaches are described in the present work. Using the resulting simulation model, optimal operating conditions can be identified to minimize both the energy requirement and the solvent degradation in the process. This kind of process model assessing solvent degradation may contribute to the design of large-scale CO2 capture plants to consider not only the process energy penalty, but also its environmental penalty. Indeed, both aspects are relevant for the large-scale deployment of the CO2 capture technology. [less ▲]

Detailed reference viewed: 43 (18 ULg)