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 References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 1101 to 1200 of 51356     7 8 9 10 11 12 13 14 15 16 17     Pour une étude croisée des armes et des lettresDumont, Jonathan ; Masson, Christophe in Moyen Age (Le) (2015), CXXI(I), 11-20Detailed reference viewed: 19 (6 ULg) Remote sensing enables high discrimination between organic and non-organic cotton for organic cotton certification in West AfricaDenis, Antoine ; Tychon, Bernard in Agronomy for Sustainable Development (2015)One of the challenges of organic crop certification is the efficient targeting of the relatively small percentage of risk-sensitive fields that have to be controlled during the regulatory annual in situ ... [more ▼]One of the challenges of organic crop certification is the efficient targeting of the relatively small percentage of risk-sensitive fields that have to be controlled during the regulatory annual in situ inspection. A previous study carried out on wheat and maize in Germany has shown that organic and non-organic crops can be efficiently distinguished by remote sensing. That study pointed to the possibility that these techniques could be used for helping organic crop certification bodies to better target risk-sensitive fields. This study is a first adaptation of that research on organic cotton in southwestern Burkina Faso, West Africa. This study assumed that organic and non-organic cotton, primarily because of their different approaches to fertilization and pest control, would result in bio-chemico-physical differences measurable by both in situ and remote sensing indicators. This study included 100 cotton fields, of which 50 were organic, 28 conventional, and 22 genetically modified. In situ indicators were derived from chlorophyll content, canopy cover, height, and spatial heterogeneity measurements. Remote sensing spectral and spatial heterogeneity indicators were derived from two SPOT 5 satellite images. Discriminant models were then computed. The results show statistically highly significant differences between organic and non-organic cotton fields for both in situ and satellite indicators, using univariate and multivariate linear models, with up to 86 % discrimination performance. This is the first time that the efficiency of using remote sensing to discriminate between organic and non-organic crops is evaluated in a developing country, particularly for cotton, with good discrimination being achieved. Pending further validation, it therefore seems that remote sensing could be used to enhance organic cotton certification in West Africa by enabling more efficient targeting of suspect fields and consequently could contribute to a better development of this sector. [less ▲]Detailed reference viewed: 25 (4 ULg) Simulation-based study comparing multiple imputation methods for non-monotone missing ordinal data in longitudinal settingsDonneau, Anne-Françoise ; Mauer, Murielle; Lambert, Philippe et alin Journal of Biopharmaceutical Statistics (2015), 25(03), 570-601The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the ... [more ▼]The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the joint modeling and the fully conditional specification approaches. Their relative performance for the longitudinal ordinal data setting under the missing at random (MAR) assumption is not well documented. This paper intends to fill this gap by conducting a large simulation study on the estimation of the parameters of a longitudinal proportional odds model. The two MI methods are also illustrated in quality of life data from a cancer clinical trial. [less ▲]Detailed reference viewed: 105 (28 ULg) Principal-component analysis of particle motionChen, Hui Yao; Liegeois, Raphaël ; de Bruyn, John et alin Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2015)We demonstrate the application of principal-component analysis (PCA) to the analysis of particle motion data in the form of a time series of images. PCA has the ability to resolve and isolate ... [more ▼]We demonstrate the application of principal-component analysis (PCA) to the analysis of particle motion data in the form of a time series of images. PCA has the ability to resolve and isolate spatiotemporal patterns in the data. Using simulated data, we show that this translates into the ability to separate individual frequency components of the particle motion. We also show that PCA can be used to extract the fluid viscosity from images of particles undergoing Brownian motion. PCA thus provides an efficient alternative to more traditional particle-tracking methods for the analysis of microrheological data. [less ▲]Detailed reference viewed: 14 (2 ULg) Les initiatives commerciales de bioraffinage en Région Wallonne: production de biocarburants et voies de valorisation connexesJacquet, Nicolas ; Desquay, Lucas ; Jadot, Bastien et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(2), 197-203Introduction Biorefining is progressively gaining interest in Wallonia as a complement to the conventional petrochemical industry. Biorefineries are categorized according to the nature of the raw ... [more ▼]Introduction Biorefining is progressively gaining interest in Wallonia as a complement to the conventional petrochemical industry. Biorefineries are categorized according to the nature of the raw materials they treat (food or non-food) and the nature of their productions (energy and biofuels or biobased compounds). Literature Production of first-generation and second-generation biofuels (bioethanol and biodiesel) is described, as well as their parallel valorisation pathways. A description of the Belgian biobased industry is also provided. Conclusion Diversification of supply chains, as well as the need to promote a circular economy, becomes a priority for the development of biorefining in Wallonia. [less ▲]Detailed reference viewed: 50 (14 ULg) Image analysis of X-ray tomograms of sludge during convective drying in a pilot-scale fixed bedLi, Jie ; Plougonven, Erwan ; Fraikin, Laurent et alin Chemical Engineering Science (2015), 134Detailed reference viewed: 16 (2 ULg) Single-Walled Metal–Organic Nanotube Built from a Simple SynthonAdarsh, Nayarassery; Dirtu, Marinela; Naik, Anil et alin Chemistry : A European Journal (2015), 21Detailed reference viewed: 12 (0 ULg) Hypersonic Aerothermochemistry Duplication in Ground Plasma Facilities: A Flight-to-Ground ApproachSakraker, Isil ; Turchi, Alessandro; Chazot, Olivierin Journal of Spacecraft & Rockets (2015)High conservative safety margins, applied to the design of spacecraft thermal protection systems for planetary entry, need to be reduced for higher efficiency of future space missions. Ground testing of ... [more ▼]High conservative safety margins, applied to the design of spacecraft thermal protection systems for planetary entry, need to be reduced for higher efficiency of future space missions. Ground testing of such protection systems is of great importance during the design phase. This study covers a methodology for simulating the complex hypersonic entry aerothermochemistry in a plasma wind tunnel for a given spacecraft geometry without any assumption on axisymmetry or bluntness. A demonstration of this proposed methodology is made on the Qubesat for Aerothermodynamic Research and Measurements on AblatioN, QARMAN mission, which is a rectangular reentry CubeSat with a cork-based ablative thermal protection system in the front unit. The reacting boundary-layer profiles of the hypersonic entry probe compare well with the ones developing at the stagnation region of the plasma test model, defined with the proposed flight-to-ground duplication method. [less ▲]Detailed reference viewed: 23 (3 ULg) Amélioration de la biodégradation du biphényle par Rhodococcus erythropolis t902.1 en présence de Fe2O3 et de nanoparticules de fer encapsulées dans un xérogel de silicewanoussa; Hiligsmann, Serge ; Tasseroul, Ludivine et alin Déchets Sciences et Techniques (2015), 69In this work, the effect of iron oxide particles Fe2O3 and iron nanoparticles encapsulated in a porous silica matrix (xerogel Fe/SiO2) was investigated on biphenyl biodegradation by the strain Rhodococcus ... [more ▼]In this work, the effect of iron oxide particles Fe2O3 and iron nanoparticles encapsulated in a porous silica matrix (xerogel Fe/SiO2) was investigated on biphenyl biodegradation by the strain Rhodococcus erythropolis T902.1. After 18 days of incubation biodegradation yields of 75% and 85% were achieved respectively in presence of non-autoclaved or autoclaved xerogel Fe/SiO2 at 10-5 M iron. These results are 42 and 60 % higher than in standard conditions without nanoparticles. They suggest that the autoclave procedure lead to the release of some iron less anchored in the silica matrix. This study highlights that siderophore production by Rhodococcus erythropolis T902.1 would be related to the presence of iron nanoparticles in the culture. It suggests that the production of these strong chelating compounds decreases with increase of iron release from xerogel Fe/SiO2. Moreover, most of the surfactants synthesized by Rhodococcus erythropolis T902.1 which are glycolipids containing trehalose (hexose), would be linked to cell surface and not excreted in the culture medium; the biomass hexose content also increased by 85% in presence of iron nanoparticles. [less ▲]Detailed reference viewed: 30 (4 ULg) Fonctionnement exécutif et attentionnel consécutif à des lésions cérébrales acquises : une analyse de cas multiplesHogge, Michael; Salmon, Eric ; Collette, Fabienne in Revue de Neuropsychologie, Neurosciences Cognitives et Cliniques (2015), 7(2), 71-99Le fonctionnement exécutif a été conceptualisé comme un ensemble de processus cognitifs de haut niveau pouvant être clairement distingués, et dont le substrat cérébral se situerait au sein des régions ... [more ▼]Le fonctionnement exécutif a été conceptualisé comme un ensemble de processus cognitifs de haut niveau pouvant être clairement distingués, et dont le substrat cérébral se situerait au sein des régions frontales. Un certain nombre de données obtenues notamment chez des patients présentant des lésions cérébrales acquises sont toutefois venues remettre en question cette conceptualisation. Dans ce contexte, nous avons administré une large batterie d’épreuves exécutives et attentionnelles à un petit groupe de patients cérébro-lésés (N=9) afin de déterminer, au moyen d’analyses de cas multiples, l’influence de la localisation et de l’étendue des lésions, ainsi que l’influence de difficultés attentionnelles, sur la survenue d’un syndrome dysexécutif. Les analyses de profils individuels semblent indiquer qu’un mauvais transfert d’information entre régions cérébrales antérieures et postérieures serait responsable de la survenue de troubles exécutifs, et que, dans certains cas, ce soient des difficultés attentionnelles qui déterminent ces déficits. Toutefois, il se pourrait également que l’atteinte de certaines régions clés (relativement focalisées) sous-tendant des processus cognitifs impliqués dans un large éventail de tâches exécutives soit responsable de la survenue d’un dysfonctionnement exécutif massif. [less ▲]Detailed reference viewed: 25 (1 ULg) Transnational Politics as Cultural Circulation: Toward a Conceptual Understanding of Migrant Political Participation on the MoveBoccagni, Paolo; Lafleur, Jean-Michel ; Levitt, Peggyin Mobilities (2015)This article contributes to the burgeoning literature on transnational politics by bringing tools used by scholars of cultural diffusion and circulation into these debates. We build on research on social ... [more ▼]This article contributes to the burgeoning literature on transnational politics by bringing tools used by scholars of cultural diffusion and circulation into these debates. We build on research on social remittances and their potential to yield broader and deeper effects or to ‘scale up’ and ‘scale out.’ Based on a variety of empirical examples, we propose that processes such as circulation, portability, and contact, viewed through a transnational optic, help to nuance recent research on political transnationalism and its empirical indicators – including, most notably, external voting. [less ▲]Detailed reference viewed: 23 (8 ULg) Algebrability and nowhere Gevrey differentiabilityBastin, Françoise ; Conejero, J. Alberto; Esser, Céline et alin Israel Journal of Mathematics (2015), 205We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and ... [more ▼]We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and, therefore, lineability) of functions enjoying this property. In the process of proving these results we also provide a new construction of nowhere Gevrey di fferentiable functions. [less ▲]Detailed reference viewed: 113 (38 ULg) Plant functional traits as a promising tool for the ecological restoration of degraded tropical metal-rich habitats and revegetation of metal-rich bare soils: A case study in copper vegetation of Katanga, DRCIlunga wa Ilunga, Edouard; Mahy, Grégory ; Piqueray, Julien et alin Ecological Engineering (2015), 82Ecological restoration of degraded metal-rich habitats and bare metal-rich soils created by mining activities has nowadays become a major environmental issue to reduce mining impacts on the erosion of ... [more ▼]Ecological restoration of degraded metal-rich habitats and bare metal-rich soils created by mining activities has nowadays become a major environmental issue to reduce mining impacts on the erosion of biodiversity and the degradation of landscape, soil and water.Studies based on species identification for restoration purposes without reference to plant trait are limited only to local pool of species which makes the interpretation and applications in various ecological contexts rather difficult. This study aims at trait analysis of metal-rich habitats in order to test the differences in plant traits in degraded primary habitat and along a successional gradient in secondary habitats. In this context, investigation of the existence of resilience or the need for ecological restoration is attempted. A second aim of this work is also the identification of traits candidates for appropriate species selection for revegetation of metal-rich bare soils purposes.Results showed that the cover of xylopodia trait values decreases according to the intensity of degradation among habitats, and can be considered an indicator of habitat degradation. Differences of traits values among primary and old secondary habitats highlighted that the absence of resilience of degraded primary steppic savanna was not explained by 14 soil factors measured.The main plant traits for revegetation of metal-rich bare soils are the following: annual life cycle, growth phenology in wet season, depth 0-10. cm of underground system. , bud bank by seeds, dispersule size <2. mm. ×. 2. mm and dispersal mode by adhesion.Future challenge would be to develop new functional ecosystem on metal-rich bare soils promoting biodiversity conservation and ecosystem services related to water and soil protection. This would require the association of species selected for revegetation and phytostabilization from plant traits occurring in secondary metalliferous habitats and species selected from plant traits specific to primary habitats. © 2015 Elsevier B.V. [less ▲]Detailed reference viewed: 14 (0 ULg) Island floras are not necessarily more species-poor than continental ones.Patiño, J.; Solymos, P.; Carine, M.A. et alin Journal of Biogeography (2015), 42Detailed reference viewed: 24 (0 ULg) Recel et repentirMoreau, Pierre in Revue de Jurisprudence de Liège, Mons et Bruxelles (2015), (17), 797-798Detailed reference viewed: 10 (0 ULg) An analogue of Cobham's theorem for graph directed iterated function systemsCharlier, Emilie ; Leroy, Julien ; Rigo, Michel in Advances in Mathematics (2015), 280Feng and Wang showed that two homogeneous iterated function systems in $\mathbb{R}$ with multiplicatively independent contraction ratios necessarily have different attractors. In this paper, we extend ... [more ▼]Feng and Wang showed that two homogeneous iterated function systems in $\mathbb{R}$ with multiplicatively independent contraction ratios necessarily have different attractors. In this paper, we extend this result to graph directed iterated function systems in $\mathbb{R}^n$ with contraction ratios that are of the form $\frac{1}{\beta}$, for integers $\beta$. By using a result of Boigelot {\em et al.}, this allows us to give a proof of a conjecture of Adamczewski and Bell. In doing so, we link the graph directed iterated function systems to Büchi automata. In particular, this link extends to real numbers $\beta$. We introduce a logical formalism that permits to characterize sets of $\mathbb{R}^n$ whose representations in base $\beta$ are recognized by some Büchi automata. This result depends on the algebraic properties of the base: $\beta$ being a Pisot or a Parry number. The main motivation of this work is to draw a general picture representing the different frameworks where an analogue of Cobham's theorem is known. [less ▲]Detailed reference viewed: 33 (14 ULg) The age of river-transported carbon: A global perspectiveMarwick, Trent R.; Tamooh, Fredrick; Teodoru, Cristian R. et alin Global Biogeochemical Cycles (2015), 29(2), 122--137The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of ... [more ▼]The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of different riverine C pools, there remain large regions for which no data are available and no comprehensive attempts to synthesize the available information and examine global patterns in the 14C content of different riverine C pools. Here we present new 14C data on particulate and dissolved organic C (POC and DOC) from six river basins in tropical and subtropical Africa and compiled >1400 literature Δ14C data and ancillary parameters from rivers globally. Our analysis reveals a consistent pattern whereby POC is progressively older in systems carrying higher sediment loads, coinciding with a lower organic carbon content. At the global scale, this pattern leads to a proposed global median Δ14C signature of −203‰, corresponding to an age of ~1800 years B.P. For DOC exported to the coastal zone, we predict a modern (decadal) age (Δ14C = +22 to +46‰), and paired data sets confirm that riverine DOC is generally more recent in origin than POC—in contrast to the situation in ocean environments. Weathering regimes complicate the interpretation of 14C ages of dissolved inorganic carbon, but the available data favor the hypothesis that in most cases, more recent organic C is preferentially mineralized. [less ▲]Detailed reference viewed: 29 (3 ULg) Clinical Significance of Exercise Pulmonary Hypertension in Secondary Mitral Regurgitation.Lancellotti, Patrizio ; Magne, Julien; DULGHERU, Raluca Elena et alin The American journal of cardiology (2015)In patients with heart failure, exercise echocardiography can help in risk stratification and decision making. The prognostic significance of exercise pulmonary hypertension (PH) in patients with ... [more ▼]In patients with heart failure, exercise echocardiography can help in risk stratification and decision making. The prognostic significance of exercise pulmonary hypertension (PH) in patients with secondary mitral regurgitation (MR) remains unknown. The aim of the present study was to assess the prognostic value of exercise PH in patients with secondary MR and narrow QRS intervals. From 2005 to 2012, 159 consecutive patients with secondary MR, narrow QRS intervals, left ventricular dysfunction (mean ejection fraction 36 +/- 7%), and measurable systolic pulmonary arterial pressure (SPAP) during exercise echocardiography were included. Resting and exercise PH were defined as SPAP >50 and >60 mm Hg, respectively. Exercise PH was more frequent than resting PH (40% vs 13%, p <0.0001). On multivariate logistic regression, the independent determinants of exercise PH were resting SPAP (p <0.0001), exercise MR severity (p <0.0001), and e'-wave velocity (p = 0.004). The incidence of cardiac events during follow-up was significantly higher in patients with exercise PH compared with those without exercise PH (4 years: 40 +/- 7% vs 20 +/- 5%, p <0.0001). Patients with exercise PH exhibited higher rates of cardiac events and death than those with resting PH. In a multivariate Cox proportional hazards model, exercise PH was independently associated with the occurrence of cardiac events (p <0.0001). In conclusion, in patients with secondary MR, exercise PH is determined mainly by resting SPAP, left ventricular diastolic burden, and exercise MR severity. Exercise PH is a powerful predictor of poor outcomes, with a 5.3-fold increased risk for cardiac-related death during follow-up. These results highlight the added value of exercise echocardiography in secondary MR. [less ▲]Detailed reference viewed: 14 (1 ULg) Are Children Conservative, Liberal or Metacognitive? Preliminary Evidence for the Involvement of the Distinctiveness Heuristic in Decision MakingGeurten, Marie ; Willems, Sylvie ; Meulemans, Thierry in Journal of Experimental Child Psychology (2015), 132The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children ... [more ▼]The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children, aged 4, 6, and 9 years, studied two lists of unrelated items. One of these lists was visually displayed (picture condition) while the other was presented auditorily (word condition). After each study phase, participants completed recognition tests. Finally, they answered questions about their explicit knowledge of the distinctive-encoding effect. The results revealed that even the youngest children in our sample showed a smaller proportion of intrusions in the picture condition than in the word condition. Furthermore, the results of the signal detection analyses were consistent with the hypothesis that the lower rate of false recognitions after picture encoding results from the implementation of a conservative response criterion based on metacognitive expectations (distinctiveness heuristic). Moreover, the absence of correlation between children’s explicit knowledge of the distinctiveness rule and their effective use of this metacognitive heuristic seems to indicate that its involvement in memory decisions could be mediated by implicit mechanisms. [less ▲]Detailed reference viewed: 36 (5 ULg) A Systematic Review of Cost-Effectiveness Analyses of Drugs for Postmenopausal Osteoporosis.Hiligsmann, Mickaël ; Evers, Silvia M.; Ben Sedrine, Wafa et alin PharmacoEconomics (2015), 33(3), 205-224BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal ... [more ▼]BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal osteoporosis remains and even increases. OBJECTIVE: This study aims to identify all recent economic evaluations on drugs for postmenopausal osteoporosis, to critically appraise the reporting quality, and to summarize the results. METHODS: A literature search using Medline, the National Health Service Economic Evaluation database and the Cost-Effectiveness Analysis Registry was undertaken to identify original articles published between January 1, 2008 and December 31, 2013. Studies that assessed cost effectiveness of drugs in postmenopausal osteoporosis were included. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement was used to assess the quality of reporting of these articles. RESULTS: Of 1,794 articles identified, 39 studies fulfilled the inclusion criteria. They were conducted in 14 different countries and nine active interventions were assessed. When compared with no treatment, active osteoporotic drugs were generally cost effective in postmenopausal women aged over 60-65 years with low bone mass, especially those with prior vertebral fractures. Key drivers of cost effectiveness included individual fracture risk, medication adherence, selected comparators and country-specific analyses. Quality of reporting varied between studies with an average score of 17.9 out of 24 (range 7-21.5). CONCLUSION: This review found a substantial number of published cost-effectiveness analyses of drugs in osteoporosis in the last 6 years. Results and critical appraisal of these articles can help decision makers when prioritizing health interventions and can inform the development of future economic evaluations. [less ▲]Detailed reference viewed: 30 (10 ULg) Faire la guerre, faire l’État. Les officiers « militaires » sous les trois premiers souverains Valois de NaplesMasson, Christophe in Mélanges de l'Ecole française de Rome. Moyen-Age (2015), CXXVII(I), From Louis Ist to René Ist, the Valois dukes of Anjou tried to establish their power on the kingdom of Naples. The former had indeed been adopted by Jeanne Ist, the last queen of the Capetian dynasty. The ... [more ▼]From Louis Ist to René Ist, the Valois dukes of Anjou tried to establish their power on the kingdom of Naples. The former had indeed been adopted by Jeanne Ist, the last queen of the Capetian dynasty. The Valois dukes led several military expeditions to establish their power in Naples, facing the rivalry of the Anjou-Duras and then of the Aragon dynasty. These armies would later on constitute the framework of the Valois’s local administration in Italy. This paper will examine how the three first dukes of Anjou exerted military power. On the one hand, the smaller military responsibilities—exerted on a limited geographical area—were most of the time entrusted to Neapolitean subjects. On the other hand, the officers in charge of the conduct of armies and of the strongholds close to the prince (castles or province of residence) turned out to be most of the time entrusted to foreigners. In sum, the balance of power between the local feudal lords and the duke of Anjou drew the military structures of the royal power; and each of the parties found there its own interest. [less ▲]Detailed reference viewed: 12 (0 ULg) Boosting regulatory T-cell function with the humanized CD4-specific humanized monoclonal antibody Tregalizumab (BT-061)Humblet-Baron, Stéphanie; Baron, Frédéric in Immunology & Cell Biology (2015), 1-2Detailed reference viewed: 16 (3 ULg) Sartre in Venedig: der Mann, der in die Kälte gingCormann, Grégory ; Viehöver, Vera in Bulletin d'Analyse Phénoménologique (2015), 11Detailed reference viewed: 28 (3 ULg) Rituximab therapy for hairy cell leukemia : a retrospective study of 41 casesLeclerc, Mathieu; Suarez, Felipe; Noël, Marie-Pierre et alin Annals of Hematology (2015), 94The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and ... [more ▼]The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 centers in France and Belgium, who received 49 treatment courses with the anti-CD20 monoclonal antibody rituximab. Most of the patients were treated at relapse (84 % of cases) and rituximab was combined to a PA in 41 % of cases. Overall, response rate is 90 % including 71 % complete hematologic responses (CHRs). Frontline treatment, combination therapy, and absolute neutrophil count were associated with response in multivariate analysis. Three-year relapse-free and overall survivals are 68 and 90 %, respectively. When combined to a PA, rituximab yields a 100 % response rate, even beyond frontline therapy. In contrast, response rate is only 82 % (59 % CHR) when rituximab is used alone. In this latter setting, relapse rate is 56 % and median time to relapse is 17.5 months. All eight patients who were treated two times with the antibody responded again to retreatment. We confirm the high efficacy of the combination rituximab + PA. However, when rituximab is used as monotherapy, response rate is lower and the high relapse rate is a concern. Prospective clinical trials are needed to confirm the superiority of the combination rituximab + PA over PA alone, both as frontline therapy and at relapse. [less ▲]Detailed reference viewed: 15 (1 ULg) The Impact of Attentional Allocation Capacities on Nonword Repetition in Children with Specific Language ImpairmentLeclercq, Anne-Lise ; Maillart, Christelle ; Lange, Manon et alin Clinical Linguistics & Phonetics (2015)This study aimed at directly assessing the hypothesis that attentional allocation capacity influences poor NWR performances in children with SLI, using an attention demanding visual search task given ... [more ▼]This study aimed at directly assessing the hypothesis that attentional allocation capacity influences poor NWR performances in children with SLI, using an attention demanding visual search task given concurrently with the NWR task. Twenty-one children with SLI, 21 typically-developing children matched on age, and 21 typically-developing children matched on nonword span performed an immediate serial recall task of nonwords. The nonword lists were presented either alone or concurrently with the visual search task. Overall, results revealed a resource-sharing trade-off between the two tasks. Children with SLI were affected to the same extent as their span-matched controls by the necessity to allocate their attentional resources between the two tasks. Interestingly, nonword processing strategies seemed to differ among groups: age-matched controls allocated a larger part of their attentional resources to the encoding stage, while nonword recall was more attention demanding in children with SLI and younger controls. [less ▲]Detailed reference viewed: 32 (4 ULg) Short-term Effect of Infliximab Is Reflected in the Clot Lysis Profile of Patients with Inflammatory Bowel Disease: A Prospective Study.Bollen, Lize; Vande Casteele, Niels; Peeters, Miet et alin Inflammatory bowel diseases (2015), 21(3), 570-8BACKGROUND: Inflammatory bowel disease (IBD) is recognized as an independent risk factor for thrombosis. First, we investigate whether the concentration of fibrinolysis inhibitors is increased in patients ... [more ▼]BACKGROUND: Inflammatory bowel disease (IBD) is recognized as an independent risk factor for thrombosis. First, we investigate whether the concentration of fibrinolysis inhibitors is increased in patients with IBD. Second, we investigate the effect of infliximab induction therapy on the hemostatic profile. METHODS: This prospective study included 103 patients with IBD starting infliximab therapy and 113 healthy controls. Plasma was collected before the first infliximab infusion (wk 0) and after induction therapy (wk 14). Patients not showing a clinical response on induction were considered as primary nonresponders. Fibrinolysis inhibitors were measured by enzyme-linked immunosorbent assay. Using a clot lysis assay, the area under the curve (global marker for coagulation/fibrinolysis), 50% clot lysis time (marker for fibrinolytic capacity), and amplitude (indicator for clot formation) were determined. RESULTS: Patients with IBD selected for infliximab treatment have higher area under the curve (median 29 [interquartile range, 20-38]) and amplitude (0.4 [0.3-0.5]) compared with healthy controls (18 [13-24] and 0.3 [0.2-0.3], respectively, P < 0.001). Primary nonresponders showed a decrease neither in inflammatory markers nor in hemostatic parameters, whereas in primary responders, a decrease in inflammatory markers was associated with a decrease in both area under the curve (29 [20-38] (wk 0) to 20 [14-28] (wk 14), P < 0.001) and amplitude (0.4 [0.3-0.5] (wk 0) to 0.3 [0.3-0.4] (wk 14), P < 0.001). CONCLUSIONS: This is the first prospective study demonstrating that the clot lysis profile differs between patients with IBD and healthy individuals. On infliximab induction treatment, this clot lysis profile normalizes in responders suggesting that infliximab treatment is advisable for patients with IBD with an activated hemostatic profile. [less ▲]Detailed reference viewed: 14 (3 ULg) Cancer du sein : de la thérapie ciblée à la médecine personnaliséeJERUSALEM, Guy ; COLLIGNON, Joëlle ; Josse, Claire et alin Revue Médicale de Liège (2015), 70(5-6), 269-276Dans cet article, les auteurs passent en revue les grands principes de prise en charge du traitement systémique du cancer du sein et posent la question suivante : jusqu'où réellement aujourd'hui ce ... [more ▼]Dans cet article, les auteurs passent en revue les grands principes de prise en charge du traitement systémique du cancer du sein et posent la question suivante : jusqu'où réellement aujourd'hui ce traitement est-il individualisé ? Les nouvelles technologies permettent une analyse détaillée des anomalies génomiques au niveau des cellules cancéreuses. Malheureusement, nous n'avons pas encore compris comment utiliser au mieux ces données au bénéfice du patient. La majorité des modifications du génome sont des évènements relativement rares compliquant le développement de nouveaux médicaments dans le cadre d'une médecine de précision. De plus, les tumeurs présentent une grande hétérogénéité temporelle et spatiale dont il faudra tenir compte lors de ce développement. Une collaboration internationale intensive est en cours pour tenter de confirmer que la médecine de précision permet d'optimiser les résultats du traitement systémique dans le cancer du sein. [less ▲]Detailed reference viewed: 104 (2 ULg) Effects of nutritional programming on growth and metabolism caused by albumen removal in an avian modelWillems, E.; Koppenol, A.; De Ketelaere, B. et alin Journal of Endocrinology (2015), 225Detailed reference viewed: 19 (1 ULg) Assessment of contaminant levels and trophic relations at a World Heritage Site by measurements in a characteristic shorebird speciesSchwemmer, Philipp; Covaci, Adrian; Das, Krishna et alin Environmental Research (2015), 136The River Elbe is responsible for influxes of contaminants into the Wadden Sea World Heritage Site. We investigated levels of polychlorinated biphenyls (PCBs), oxychlordane (OxC), hexachlorobenzene (HCB ... [more ▼]The River Elbe is responsible for influxes of contaminants into the Wadden Sea World Heritage Site. We investigated levels of polychlorinated biphenyls (PCBs), oxychlordane (OxC), hexachlorobenzene (HCB), hexachlorocyclohexanes (α-, β-, γ-HCHs), dichlorodiphenyltrichloroethane (DDT) and its metabolites, and polybrominated diphenyl ethers (PBDEs) in blood and feathers from Eurasian oystercatchers (Haematopus ostralegus; n=28) at the Elbe and compared it with a non-riverine site about 90 km further north. (1) Mean levels of all contaminants in feathers and serum were significantly higher at the river (ƩPCBs: 27.6 ng/g feather, 37.0 ng/ml serum; ƩDDTs: 5.3 ng/g feather, 4.4 ng/ml serum) compared with the non-riverine site (ƩPCBs: 6.5 ng/g feather, 1.2 ng/ml serum; ƩDDTs: 1.4 ng/g feather, 0.5 ng/ml serum). Mean ƩHCH and HCB levels were <1.8 ng/g in feather and <1.8 ng/ml in serum at both sites. (2) Levels of most detectable compounds in serum and feathers were significantly related, but levels were not consistently higher in either tissue. (3) There was no significant relationship between trophic level in individual oystercatchers (expressed as δ15N) or the degree of terrestrial feeding (expressed as δ13C) and contaminant loads. (4) PBDEs were not detected in significant amounts at either site. The results of this study indicate that the outflow from one of Europe’s largest river systems is associated with significant historical contamination, reflected by the accumulation of contaminants in body tissues in a coastal benthivore predator. [less ▲]Detailed reference viewed: 45 (7 ULg) Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis.Grange, Laura; Bureau, Jean-Francois; Nikolayeva, Iryna et alin BMC genetics (2015), 16(1), 11BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the ... [more ▼]BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the heritability of traits and diseases. Epistasis, one potentially important cause of this missing heritability, is difficult to explore at the genome-wide level. Here, we develop and assess a tool based on interactive odds ratios (IOR), Fast Odds Ratio-based sCan for Epistasis (FORCE), as a novel approach for exhaustive genome-wide epistasis search. IOR is the ratio between the multiplicative term of the odds ratio (OR) of having each variant over the OR of having both of them. By definition, an IOR that significantly deviates from 1 suggests the occurrence of an interaction (epistasis). As the IOR is fast to calculate, we used the IOR to rank and select pairs of interacting polymorphisms for P value estimation, which is more time consuming.ResultsFORCE displayed power and accuracy similar to existing parametric and non-parametric methods, and is fast enough to complete a filter-free genome-wide epistasis search in a few days on a standard computer. Analysis of psoriasis data uncovered novel epistatic interactions in the HLA region, corroborating the known major and complex role of the HLA region in psoriasis susceptibility.ConclusionsOur systematic study revealed the ability of FORCE to uncover novel interactions, highlighted the importance of exhaustiveness, as well as its specificity for certain types of interactions that were not detected by existing approaches. We therefore believe that FORCE is a valuable new tool for decoding the genetic basis of complex diseases. [less ▲]Detailed reference viewed: 15 (0 ULg) Le genre Guibourtia Benn., un taxon à haute valeur commerciale et sociétale (synthèse bibliographique)Tosso, Dji-ndé Félicien ; Daïnou, Kasso ; Hardy, J. Olivier et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), Known as a genus of great socio-cultural and economical importance, Guibourtia Benn. includes morphologically very similar multipurpose sister species, found in various habitats with different climate and ... [more ▼]Known as a genus of great socio-cultural and economical importance, Guibourtia Benn. includes morphologically very similar multipurpose sister species, found in various habitats with different climate and soil conditions. In many places, Guibourtia is subject to local overexploitation by forest companies and local communities. As the population density of Guibourtia species is generally very low, it may be necessary to conduct scientific investigations that will provide valuable information for the management of the populations concerned. This paper is based on an extensive literature review and summarizes the available information on the genus Guibourtia, in terms of botany, ecology, genetics, forestry and ethnobotany. Our review provided evidence that, to date, ecological and silvicultural knowledge regarding Guibourtia species is lacking and that it is very difficult to morphologically differentiate very similar sister species. In addition, we provide a new determination key for the genus Guibourtia. Based on the available information, it is difficult to assess the conservation status of these taxa. Further investigations are needed to suggest appropriate management strategies for Guibourtia. Moreover, species diversity within this genus and its distribution in various tropical biomes make it an excellent biological model for understanding the historical, biological and environmental mechanisms that explain the diversity of tropical moist forests. [less ▲]Detailed reference viewed: 21 (10 ULg) Cell based advanced therapeutic medicinal products for bone repair: Keep it simple?Leijten, J.; Chai, Y. C.; Papantoniou, I. et alin Advanced drug delivery reviews (2015), 84The development of cell based advanced therapeutic medicinal products (ATMPs) for bone repair has been expected to revolutionize the health care system for the clinical treatment of bone defects. Despite ... [more ▼]The development of cell based advanced therapeutic medicinal products (ATMPs) for bone repair has been expected to revolutionize the health care system for the clinical treatment of bone defects. Despite this great promise, the clinical outcomes of the few cell based ATMPs that have been translated into clinical treatments have been far from impressive. In part, the clinical outcomes have been hampered because of the simplicity of the first wave of products. In response the field has set-out and amassed a plethora of complexities to alleviate the simplicity induced limitations. Many of these potential second wave products have remained "stuck" in the development pipeline. This is due to a number of reasons including the lack of a regulatory framework that has been evolving in the last years and the shortage of enabling technologies for industrial manufacturing to deal with these novel complexities. In this review, we reflect on the current ATMPs and give special attention to novel approaches that are able to provide complexity to ATMPs in a straightforward manner. Moreover, we discuss the potential tools able to produce or predict 'goldilocks' ATMPs, which are neither too simple nor too complex. [less ▲]Detailed reference viewed: 4 (0 ULg) Re: Chung et al.'s Letter to the Editor in response to: Early detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model. Med Eng Phys 2014;36(September (9)):1101-5 by Morimont et al.MORIMONT, Philippe ; Pironet, Antoine ; Desaive, Thomas et alin Medical engineering & physics (2015)Detailed reference viewed: 19 (0 ULg) Jean-Marie KAJDANSKI, Pain gris, 2014.Baiwir, Esther in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2015), (1/2015), 13-14Detailed reference viewed: 38 (0 ULg) La notification du décès d’une partie à la causeMoreau, Pierre in Revue de Jurisprudence de Liège, Mons et Bruxelles (2015), (17), 778-779Detailed reference viewed: 14 (0 ULg) Support Functionalization To Retard Ostwald Ripening in Copper Methanol Synthesis CatalystsVan den Berg, Roy; Parmentier, Tanja; Elkjaer, Christian et alin ACS Catalysis (2015), 5A main reason for catalyst deactivation in supported catalysts for methanol synthesis is copper particle growth. We have functionalized the support surface in order to suppress the formation and/or ... [more ▼]A main reason for catalyst deactivation in supported catalysts for methanol synthesis is copper particle growth. We have functionalized the support surface in order to suppress the formation and/or transport of mobile copper species and thereby catalyst deactivation. A Stöber silica support was functionalized by treatment with aminopropyltriethoxysilane, which introduces aminopropyl groups on the surface. Copper was deposited on both unfunctionalized and functionalized Stöber silica via incipient wetness impregnation with aqueous copper nitrate solutions followed by drying and calcination. Similar particle size distributions (1−5 nm) were obtained for both supports by changing the flow of N2 to a flow of 2% NO/N2 during calcination of the unfunctionalized and amine functionalized silica, respectively. The effect of support functionalization with aminopropyl groups was an increased stability in the methanol synthesis reaction (40 bar, 260 °C, 23% CO/7% CO2/60% H2/10% Ar, 3% COx conversion) due to more limited copper particle growth as determined by transmission electron microscopy (TEM). Changing the interparticle distance did not have an influence on the deactivation rate, while the addition of few very large copper particles did, indicating that Ostwald ripening was most probably the dominant particle growth mechanism for these samples. In situ TEM images showed the contact angle between the reduced copper particles and the support. As shape and size was similar on silica as on amine-functionalized silica, the thermodynamic stability of the copper particles was unaltered. The driving force for copper particle growth was thus unchanged upon functionalization. We therefore suggest that Ostwald ripening in methanol synthesis catalysts was retarded by inhibiting the transport of copper species over the support surface. Diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) revealed a decrease in the number of surface groups (hydroxyl, methoxy, and aminopropyl) upon functionalization because aminopropyltriethoxysilane reacted with multiple hydroxyl groups. Because of that, the distance between neighboring functional groups was increased, suppressing the mobility of Ostwald ripening species from one copper particle to another. [less ▲]Detailed reference viewed: 30 (1 ULg) Préciser, argumenter et évaluer les objectifs thérapeutiques pour améliorer la prise en charge orthophoniqueMartinez Perez, Trecy ; dor, Orianne ; Maillart, Christelle in Rééducation Orthophonique (2015), 261L’adage « reculer pour mieux sauter » s’applique parfaitement à l’étape de définition du projet thérapeutique. Prendre le temps de sélectionner les objectifs, définir les résultats attendus, choisir les ... [more ▼]L’adage « reculer pour mieux sauter » s’applique parfaitement à l’étape de définition du projet thérapeutique. Prendre le temps de sélectionner les objectifs, définir les résultats attendus, choisir les techniques d’intervention, identifier la progression à proposer dans les activités et anticiper l’évaluation de l’intervention, constituent des composantes essentielles de l’action thérapeutique. A travers cet article, nous développons quatre dimensions importantes du projet thérapeutique : l’individualisation sur base d’une l’évaluation langagière statique et dynamique, d’une concertation avec le patient et son entourage et de l’identification des facilitants et obstacles à la prise en charge ; la précision des objectifs à court terme pour assurer la cohérence et la continuité des interventions ; la prise de décisions argumentées à propos des objectifs à long terme prioritaires, de la sélection de la cible, de la stratégie d’intervention à privilégier ; et finalement l’évaluation de l’intervention afin d’en vérifier l’efficacité, le transfert et la spécificité. De cette manière, le projet va guider l’action de l’orthophoniste et servir de repère à son intervention. [less ▲]Detailed reference viewed: 112 (2 ULg) Photocatalytic decolorization of Gentian Violet with Na-doped (SnO2 and ZnO)Benhebal, Hadj; Chaib, Messaoud; Crine, Michel et alin Chiang Mai Journal of Sciences (2015), 42Photocatalysis is a technique used for the purification and decolorization of water. In this work, the photocatalytic decolorization of aqueous solutions of Gentian Violet has been investigated. The ... [more ▼]Photocatalysis is a technique used for the purification and decolorization of water. In this work, the photocatalytic decolorization of aqueous solutions of Gentian Violet has been investigated. The photocatalysts used for the study are tin dioxide (SnO2) and zinc oxide (ZnO) doped with sodium and prepared by sol-gel process. Photocatalysts were synthesised by sol-gel process and characterized by several techniques such as X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer, Emmett and Teller (BET) method and UV-vis Spectroscopy. The results of photocatalytic activity of gentian violet degradation under ultraviolet irradiation, indicated that the synthesised photocatalyst exhibit good photocatalytic performance. [less ▲]Detailed reference viewed: 16 (1 ULg) Bayesian inversions of a dynamic vegetation model at four European grassland sitesMinet, Julien ; Laloy, Eric; Tychon, Bernard et alin Biogeosciences (2015), 12(9), 2809--2829Eddy covariance data from four European grassland sites are used to probabilistically invert the CARAIB (CARbon Assimilation In the Biosphere) dynamic vegetation model (DVM) with 10 unknown parameters ... [more ▼]Eddy covariance data from four European grassland sites are used to probabilistically invert the CARAIB (CARbon Assimilation In the Biosphere) dynamic vegetation model (DVM) with 10 unknown parameters, using the DREAM(ZS) (DiffeRential Evolution Adaptive Metropolis) Markov chain Monte Carlo (MCMC) sampler. We focus on comparing model inversions, considering both homoscedastic and heteroscedastic eddy covariance residual errors, with variances either fixed a priori or jointly inferred together with the model parameters. Agreements between measured and simulated data during calibration are comparable with previous studies, with root mean square errors (RMSEs) of simulated daily gross primary productivity (GPP), ecosystem respiration (RECO) and evapotranspiration (ET) ranging from 1.73 to 2.19, 1.04 to 1.56 g C m−2 day−1 and 0.50 to 1.28 mm day−1, respectively. For the calibration period, using a homoscedastic eddy covariance residual error model resulted in a better agreement between measured and modelled data than using a heteroscedastic residual error model. However, a model validation experiment showed that CARAIB models calibrated considering heteroscedastic residual errors perform better. Posterior parameter distributions derived from using a heteroscedastic model of the residuals thus appear to be more robust. This is the case even though the classical linear heteroscedastic error model assumed herein did not fully remove heteroscedasticity of the GPP residuals. Despite the fact that the calibrated model is generally capable of fitting the data within measurement errors, systematic bias in the model simulations are observed. These are likely due to model inadequacies such as shortcomings in the photosynthesis modelling. Besides the residual error treatment, differences between model parameter posterior distributions among the four grassland sites are also investigated. It is shown that the marginal distributions of the specific leaf area and characteristic mortality time parameters can be explained by site-specific ecophysiological characteristics. [less ▲]Detailed reference viewed: 24 (5 ULg) Postcolonial Thesholds: Gateways and BordersWilson, Janet; Tunca, Daria in Journal of Postcolonial Writing (2015), 51(1), 1-107Detailed reference viewed: 21 (6 ULg) Characterization of collagen fibrils after equine suspensory ligament injury: an ultrastructural and biochemical approachShikh Al Sook, Mohamad Khir ; Gabriel, Annick ; Salouci, Moustafa et alin Veterinary Journal (2015)Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the ﬁbril ... [more ▼]Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the ﬁbril morphology, as well as the collagen content and types. The purpose of this study was to evaluate, using biochemical and ultrastructural approaches, the alterations in collagen fibrils after injury. Eight Warmblood horses with visible signs of injury in only one forelimb SL were selected and specimens were examined by transmission electron microscope (TEM). Collagen types I, III and V were purified by differential salt precipitation after collagen extraction with acetic acid containing pepsin. TEM revealed abnormal organization as well as alterations in the diameter and shape of fibrils after SL injury. The bands corresponding to types I, III and V collagen were assessed by densitometry after sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Densitometric analysis indicated that the proportions of type III and type V collagen were significantly higher (P <0.001) in damaged tissues compared to normal tissues with a mean increase of 20.9 and 17.3% respectively. Concurrently, a significant decrease (P <0.001) in type I collagen within damaged tissues was recorded with a mean decrease of 15.2%. These alterations could be the hallmark of a decrease in the tissue quality and mechanical properties of the ligament. This provides new insight for subsequent research on tissue regeneration that may lead to the development of future treatment strategies for SL injury. [less ▲]Detailed reference viewed: 294 (119 ULg) La Monte Young vs The Velvet, Minimalisme vs Punk, savant vs populaire : constructions et déconstructions postmodernesLevaux, Christophe in Volume! La revue des musiques populaires (2015), 11(2), 101-121Detailed reference viewed: 7 (0 ULg) Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis.Gabriel, Maude ; Delforge, Yves ; Deward, Adeline et alin BMC Cancer (2015), 15Detailed reference viewed: 12 (4 ULg) Investigation of the links between mass transfer conditions, dissolved hydrogen concentration and biohydrogen production by the pure strain Clostridium butyricum CWBI1009Beckers, L.; Masset, J.; Hamilton, C. et alin Biochemical Engineering Journal (2015), 98Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen ... [more ▼]Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen Potential (BHP) tests and in a 2.5L anaerobic sequenced batch reactor (AnSBR) under different operating conditions regarding liquid-to-gas mass transfer. Through the addition of both stirring up to 400rpm and nitrogen sparging, the yields were enhanced from 1.6 to 3.1molH2molglucose -1 and the maximum hydrogen production rates from 140 to 278mLh-1. These original results were achieved with a pure Clostridium strain. They showed that hydrogen production was improved by a higher liquid-to-gas hydrogen transfer resulting in a lower dissolved hydrogen concentration in the culture medium and therefore in a lower bacterial inhibition. In addition, biohydrogen partitioning between the gas and the liquid phase did not conform to Henry's Law due to critical supersaturation phenomena up to seven-fold higher than the equilibrium conditions. Therefore, dissolved hydrogen concentration should be systematically measured instead of the headspace hydrogen partial pressure. A model was proposed to correlate H2 production yield and rate by the pure C. butyricum strain CWBI1009 with mass transfer coefficient KLa. [less ▲]Detailed reference viewed: 33 (9 ULg) Chemical composition and functional properties of dietary fibre extracted by Englyst and Prosky methods from the alga Ulva lactuca collected in TunisiaYaich, Hela; Garna, Haikel; Bchir, Brahim et alin Algal Research (2015), 9Nowadays there is a growing trend to find new sources of dietary fibre (DF), such as marine algae by-products that have traditionally been undervalued. In this respect, the aim of the present ... [more ▼]Nowadays there is a growing trend to find new sources of dietary fibre (DF), such as marine algae by-products that have traditionally been undervalued. In this respect, the aim of the present investigation was firstly to compare two methods of dietary fibre quantification (Englyst and Prosky) and secondly to determine the chemical composition and some of the functional properties of total and insoluble fibres extracted in accordance with the Englyst method. The dietary fibres of dried Ulva lactuca collected from the Tunisian littoral were determined by the Prosky (gravimetric method) and Englyst (enzymatic-chemical method) methods. The two extraction methods (Englyst–Prosky) provided approximately the same values in total fibres (~54%). However, they had different insoluble and soluble fibre contents. U. lactuca contained 20.53% and 31.55% of soluble fibres and 34.37% and 21.54% of insoluble fibres using the Prosky and Englyst methods, respectively. The fractionation of the insoluble dietary fibre concentrate revealed that hemicellulose was the most abundant fraction (32.49%), followed by cellulose (16.59%) and “lignin-like” compounds (1.53%). For both fibre concentrates, the main neutral sugar was glucose (20.70%–27.59%), which corresponded to hemicellulose and cellulose. The water holding capacity of insoluble fibre concentrate was relatively high. It varied between 9.32 g and 10.3 g of water/g of dry fibre at 25 °C and 80 °C, respectively. Nevertheless, the oil holding capacity of the insoluble fibre concentrate was not affected by temperature. It was about 1.08 and 1.01 g of oil/g of dry fibre at 25 °C and 80 °C. Despite the significant functional properties of fibre concentrate, the presence of lead limits its use as an ingredient in the food industry. [less ▲]Detailed reference viewed: 16 (1 ULg) Redistribution of a mixture of organic vapours inside a activated carbon filterBerezovka, Inna; Hichem, Fettaka; Salmon, Thierry et alin Chemical Engineering Journal (2015), 280X-ray tomography in a combination with gas chromatography was used for quantitative and qualitative analysis of adsorption front of organics distributed inside activated carbon filters during defined ... [more ▼]X-ray tomography in a combination with gas chromatography was used for quantitative and qualitative analysis of adsorption front of organics distributed inside activated carbon filters during defined period of storage. This approach was tested against filters partly contaminated by CCl4 and n-heptane separately and by their mixture. X-ray tomography was shown to be capable to “recognize” different organic vaporvapours adsorbed on activated carbon and to follow their movement inside filters. Gas Chromatography was used either to monitor all possible losses of adsorbed species spices from the carbon bed, or either for “seeing” the location of each component of the mixture of organics along the filter depth. Such in situ information could be useful for evaluation of lifetime of carbon filters and for a thorough understanding of adsorption process taking place under static conditions. [less ▲]Detailed reference viewed: 19 (1 ULg) Influence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrilsHuynen, Céline; Willet, Nicolas; Buell, Alexander K. et alin Biochimica et Biophysica Acta-Proteins and Proteomics (2015), 1854Detailed reference viewed: 10 (0 ULg) Geological context of the Mesolithic Heid de Fer and Ourlaine sites at Becco (Liège province, Belgium)Mottequin, Bernard; Marion, Jean-Marc in Anthropologica et Praehistorica : Bulletin de la Société Royale Belge d'Anthropologie et de Préhistoire (2015), 125/2014 (2015)In the surroundings of the hamlet of Becco (Theux, province of Liège , Belgium), the sites of "La Heid de Fer" and 'L'Ourlaine" are known to have supplied lithic materials assigned to the Early Mesolithic ... [more ▼]In the surroundings of the hamlet of Becco (Theux, province of Liège , Belgium), the sites of "La Heid de Fer" and 'L'Ourlaine" are known to have supplied lithic materials assigned to the Early Mesolithic (pre-Boreal). Located a the top a small cliff formed by sandstones and siltstones belonging to the Esneux Formation (Devonian, Famennian), "La Heid de Fer" station overlooks a steep slope developed in the shales and siltstones belonging to Lambermont and Hodimont Formations (Upper Devonian, Famennian), within which occurs an oolitic hematite level reaching several decimeters thick (0.5 m maximum). As suggested by the particular topography of these two sites, further investigations should be conducted in this area in search of other traces of the microlithic industry. [less ▲]Detailed reference viewed: 26 (3 ULg) Daclizumab versus rabbit antithymocyte globulin in high-risk renal tranplants : five-year follow-up of a randomized studyHellemans, R; Hazzan, M; Durand, D et alin American Journal of Transplantation (2015), 15Acute rejection after kidney transplantation is a major cause of allograft dysfunction and can lead to rapid loss of graft function despite anti-rejection therapy. Even when kidney function initially ... [more ▼]Acute rejection after kidney transplantation is a major cause of allograft dysfunction and can lead to rapid loss of graft function despite anti-rejection therapy. Even when kidney function initially recovers, acute rejection is associated with an increased risk of long-term graft failure (1). Acute rejection is, accordingly, a well-established surrogate endpoint for long-term outcomes. High-quality evidence has shown that induction therapy with a biological agent lowers the risk of acute rejection, and it is therefore widely administered as part of the early immunosuppressive regimen (2,3). In recipients at low immunological risk (i.e. patients with no previous exposure to human leukocyte antigens [HLA]) either lymphocyte-depleting polyclonal [less ▲]Detailed reference viewed: 16 (1 ULg) Ichthyosaurs from the Jurassic of Skye, ScotlandBrusatte, S. L.; Young, M. T.; Challands, T. J. et alin Scottish Journal of Geology (2015), 51(1), 4355Fossils of Mesozoic vertebrates are rare in Scotland, particularly specimens of marine reptiles such as plesiosaurs and ichthyosaurs. We describe a suite of ichthyosaur fossils from the Early to Middle ... [more ▼]Fossils of Mesozoic vertebrates are rare in Scotland, particularly specimens of marine reptiles such as plesiosaurs and ichthyosaurs. We describe a suite of ichthyosaur fossils from the Early to Middle Jurassic of Skye, which to our knowledge are the first ichthyosaurs from Scotland to be described and figured in detail. These fossils span approximately 30 million years, from the Sinemurian to the Bathonian, and indicate that ichthyosaurs were a major component of Scottish marine faunas during this time. The specimens include isolated teeth that could represent the most northerly known occurrences of the widespread Sinemurian species Ichthyosaurus communis, a characteristic component of the famous Lyme Regis faunas of England, suggesting that such faunas were also present in Scotland during the Early Jurassic. An associated humerus and vertebrae from Toarcian–Bajocian-aged deposits are named as a new genus and species of basal neoichthyosaurian, Dearcmhara shawcrossi. The taxonomic affinities of this taxon, which comes from a critical but poorly sampled interval in the fossil record, suggest that non-ophthalmosaurid neoichthyosaurians dominated European assemblages around the Early–Middle Jurassic boundary, and were later replaced by ophthalmosaurids, whose radiation likely took place outside Europe. Many of these specimens were collected by amateurs and donated to museum collections, a co-operative relationship essential to the preservation of Scotland’s fossil heritage. [less ▲]Detailed reference viewed: 15 (1 ULg) Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract Synergically Inhibit Inflammatory and Catabolic Mediator's Synthesis by Normal Bovine and Osteoarthritic Human Chondrocytes in MonolayerComblain, Fanny ; Sanchez, Christelle ; Lesponne, Isabelle et alin PLoS ONE (2015)Detailed reference viewed: 17 (1 ULg) Effect of improved feeding and housing, Friesian blood level and parity on milk production of Ankole x Friesian cowsKibwana, Denise Katungu; Makumyaviri, A.M.; Hornick, Jean-Luc in Pakistan Veterinary Journal (2015), 35(1), 76-80In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk ... [more ▼]In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk consumption in population. An improved farming system, including feed supplementation, Friesian cross-breeding and the sheltering of animals in stalls at night, was studied to evaluate its effect on milk production by Ankole x Friesian crossbreds. The study was performed in Beni, D.R. Congo, on two groups of 15 animals (control group-CoG and improved group-IG), homogeneous according to Friesian blood and parity levels. The improved system, Friesian blood and parity levels increased significantly milk production (P<0.001). Farming system increased milk production by 1.6 l/d (5.2 l/d vs 6.8 l/d respectively in CoG and IG). Milk production ranged from 5.3±0.04 l/d to 6.6±0.02 l/d and from 4.9±0.02 l/d to 7.2±0.02 l/d according, respectively, to Friesian blood level and parity. A significant interaction was observed between farming system and Friesian blood level, and between farming system and parity (P<0.001). The two groups were characterized by a fair adaptation to forage availability associated to climatic factors. The study showed the importance of genetic and environmental factors on the milk production of crossbred dairy cows of the region. [less ▲]Detailed reference viewed: 44 (3 ULg) Vehicle routing problems with loading constraints: State-of-the-art and future directionsPollaris, Hanne; Braekers, Kris; Caris, An et alin OR Spectrum (2015), 37(Issue 2), 297-330Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring ... [more ▼]Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring these constraints impairs planning and induces last-minute changes resulting in additional costs. Developing vehicle routing models incorporating loading constraints is critical to more efficient route planning. The last couple of years has seen a huge increase of contributions to this field of research with almost 60 % of these being published after 2009. Our contribution is twofold. First, we overview the recent developments in the literature on all vehicle types in which loading constraints play a key role (trucks, airplanes, ships, and automated guided vehicles), using a state-of-the-art classification scheme to identify the loading constraints considered in each article. Second, we identify research gaps and opportunities for future research. [less ▲]Detailed reference viewed: 50 (5 ULg) Impact of 6 % hydroxyethyl starch (HES) 130/0.4 on the correlation between standard laboratory tests and thromboelastography (TEG(R)) after cardiopulmonary bypass.HANS, Grégory ; Hartstein, Gary ; Roediger, Laurence et alin Thrombosis research (2015), 135(5), 984-9BACKGROUND: Hydroxyethyl starches (HES) affect the results of thromboelastography (TEG(R)). We sought to determine whether using HES rather than crystalloids for cardiopulmonary bypass (CPB) prime and ... [more ▼]BACKGROUND: Hydroxyethyl starches (HES) affect the results of thromboelastography (TEG(R)). We sought to determine whether using HES rather than crystalloids for cardiopulmonary bypass (CPB) prime and intraoperative fluid therapy changes the TEG cutoff values best identifying patients with a low platelet count or a low fibrinogen level after CPB. METHODS: Data from 96 patients who had on-pump cardiac surgery, a TEG(R) (kaolin-heparinase) and standard investigations of blood clotting performed after separation from CPB and protamine administration were retrospectively reviewed. Patients were assigned to the HES or crystalloid group according to whether balanced 6% HES 130/0.4 or balanced crystalloids were used for intraoperative fluid therapy and pump prime. Mutlivariable linear regression models with computation of the standardized regression coefficients were used to identify independent associations between the four main TEG parameters (R time, alpha angle, K time and MA) and the type of fluid used, the INR, the aPTT, the fibrinogen level and the platelet count. Receiver-operating-characteristic curves were used to assess the effect of HES on the ability of TEG parameters to identify patients with a platelet count<80.000mul(-1) or a fibrinogen level<1.5 gr l(-1) and on the cutoff values best identifying these patients. RESULTS: The type of fluid used significantly affected the MA (P<0.001), the K time (P<0.001) and the alpha angle (P<0.001) regardless of the results of the standard clotting tests. According to standardized ss regression coefficients the platelet count and the type of fluid used were stronger predictors of the MA, the alpha angle and the K time than the fibrinogen level. MA better predicted platelets<80.000mul(-1) than K time and alpha angle (P=0.023). The best cutoff value of MA identifying patients with platelets<80.000mul(-1) was 62mm in the crystalloid group and 53mm in the HES group. MA, K time and alpha angle were poor predictors of the postoperative fibrinogen level. CONCLUSION: HES significantly changes the cutoff value of TEG(R) MA best identifying patients<80.000mul(-1) after on-pump cardiac surgery. [less ▲]Detailed reference viewed: 13 (2 ULg) НОВАЯ ЕДИНАЯ ЭКОДОГИЧЕСКАЯ СЕДЬСКОХОЗЯЙСТВЕННАЯ ПОДИТИКА НА 2015-2020 гг. И ЕЕ РЕАДИЗАЦИЯ В ВАДДОНИИBurny, Philippe in Scientific notes of Orel State University (2015), 2(65), 42-44For realization of the new uniform agricultural policy coordinated in 2013, the government of Wallonia made some decisions left for coordination to EU member states or regions in them as in Belgium. In ... [more ▼]For realization of the new uniform agricultural policy coordinated in 2013, the government of Wallonia made some decisions left for coordination to EU member states or regions in them as in Belgium. In July 2014, the decision on introduction of the obligatory “green” payment proportional to the main payment, obligatory payment to young farmers (1,8% of the total amount of direct payments), additional payment for the first 30 hectares was made (the size is established by the member state or the region), the connected payment (21,3% of the total amount of direct payments), and obligatory main payment (29,9 % of the total amount of regional direct payments only in Wallonia). [less ▲]Detailed reference viewed: 9 (0 ULg) Transition of maternal dietary n-3 fatty acids from the yolk to the liver of broiler breeder progeny via the residual yolk sacKoppenol, A.; Buyse, J.; Everaert, Nadia et alin Poultry Science (2015), 94(1), 43-52The aim of the present study was to evaluate the transfer of maternal dietary fatty acids (FA) from the yolk to the developing offspring, with special emphasis on n-3 FA eicosapentaenoic acid (EPA) and ... [more ▼]The aim of the present study was to evaluate the transfer of maternal dietary fatty acids (FA) from the yolk to the developing offspring, with special emphasis on n-3 FA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Six hundred forty Ross 308 breeders were housed from 6 to 58 wk of age in 16 pens resulting in 4 replicates per dietary treatment. They were fed 1 of 4 diets: a basal diet, rich in n-6 FA (CON), or an n-3 FA enriched diet formulated to obtain an EPA/DHA ratio of 1/1 (EPA = DHA), 1/2 (DHA), or 2/1 (EPA). At 28, 43, and 58 wk of age, 20 eggs per treatment were collected and analyzed for FA composition. At these same breeder ages, 600 fertilized eggs per treatment were incubated. At hatch the residual yolks of 25 chicks per treatment were collected and analyzed for FA composition. At every hatch, 180 chicks per treatment were raised under standard conditions and livers were sampled at d 1, 14, 28, and 38 d for FA analysis. Concentrations of EPA in the yolk and residual yolk of eggs laid by EPA-fed breeders were highest, next-to-highest for EPA = DHA-fed breeders, next-tolowest for DHA-fed breeders, and lowest in those laid by control hens, reflecting the inclusion levels in the maternal diets. Yolk and residual yolk DHA concentrations, however, were not only elevated due to DHA supplementation, compared with the control diet, but also due to EPA supplementation. Offspring hepatic EPA concentrations were elevated until d 28 in all n-3 enriched groups, whereas hepatic DHA concentrations were only affected by EPA = DHA and DHA supplementation at d 1. No differences were found in hepatic DHA concentrations at later offspring ages. Considering the role of EPA and DHA in early development and growth, the maternal supply of these n-3 FA might improve offspring health and performance. � 2014 Poultry Science Association Inc. [less ▲]Detailed reference viewed: 23 (1 ULg) A Low-Cost Digital Image Correlation Technique for Characterising the Shear Deformation of Fabrics for Draping StudiesPierce, R. S.; Falzon, B. G.; Thompson, M. C. et alin Strain (2015)A novel digital image correlation (DIC) technique has been developed to track changes in textile yarn orientations during shear characterisation experiments, requiring only low-cost digital imaging ... [more ▼]A novel digital image correlation (DIC) technique has been developed to track changes in textile yarn orientations during shear characterisation experiments, requiring only low-cost digital imaging equipment. Fabric shear angles and effective yarn strains are calculated and visualised using this new DIC technique for bias extension testing of an aerospace grade, carbon-fibre reinforcement material with a plain weave architecture. The DIC results are validated by direct measurement, and the use of a wide bias extension sample is evaluated against a more commonly used narrow sample. Wide samples exhibit a shear angle range 25% greater than narrow samples and peak loads which are 10 times higher. This is primarily due to excessive yarn slippage in the narrow samples; hence, the wide sample configuration is recommended for characterisation of shear properties which are required for accurate modelling of textile draping [less ▲]Detailed reference viewed: 19 (2 ULg) Stellar acoustic radii, mean densities, and ages from seismic inversion techniquesBuldgen, Gaël ; Dupret, Marc-Antoine ; Reese, Daniel et alin Astronomy and Astrophysics (2015), 574Context. Determining stellar characteristics such as the radius, mass or age is crucial when studying stellar evolution or exoplanetary systems, or when characterising stellar populations in the Galaxy ... [more ▼]Context. Determining stellar characteristics such as the radius, mass or age is crucial when studying stellar evolution or exoplanetary systems, or when characterising stellar populations in the Galaxy. Asteroseismology is the golden path to accurately obtain these characteristics. In this context, a key question is how to make these methods less model-dependent. Aims: Building on the previous work of Daniel Reese, we wish to extend the Substractive Optimally Localized Averages (SOLA) inversion technique to new stellar global characteristics beyond the mean density. The goal is to provide a general framework in which to estimate these characteristics as accurately as possible in low-mass main-sequence stars. Methods: First, we describe our framework and discuss the reliability of the inversion technique and possible sources of error. We then apply this methodology to the acoustic radius, an age indicator based on the sound speed derivative and the mean density, and compare it to estimates based on the average large and small frequency separations. These inversions are carried out for several test cases including various metallicities, different mixing-lengths, non-adiabatic effects, and turbulent pressure. Results: We observe that the SOLA method yields accurate results in all test cases whereas results based on the large and small frequency separations are less accurate and more sensitive to surface effects and structural differences in the models. If we include the surface corrections of Kjeldsen et al. (2008, ApJ, 683, L175), we obtain results of comparable accuracy for the mean density. Overall, the mean density and acoustic radius inversions are more robust than the inversions for the age indicator. Moreover, the current approach is limited to relatively young stars with radiative cores. Increasing the number of observed frequencies improves the reliability and accuracy of the method. [less ▲]Detailed reference viewed: 9 (3 ULg) Le mélanome cutané sporadique au-delà de sa classification normative. Plaidoyer prenant en compte son particularisme évolutifPierard, Gérald ; Pierard-Franchimont, Claudine in Revue Médicale de Liège (2015), 70(5-6), 277-281For aeons, cutaneous sporadic melanoma, exhibiting either a slow or rapid growth rate, is identified using a set of well defined histopathological criteria. Such diagnostic step is greatly appreciated ... [more ▼]For aeons, cutaneous sporadic melanoma, exhibiting either a slow or rapid growth rate, is identified using a set of well defined histopathological criteria. Such diagnostic step is greatly appreciated, and it brings a rough estimate of the probable evolution of the cancer. Some additional assessments try to improve the progressive prognosis of cutaneous melanoma. In this scope, fractals and spectral analyses expect to better perceive the individual progressive characteristics of each tumor. The extent in the tumoral germinative compartment and the peritumoral microvascular network are explored and should in a near future make clear the progressive potential of cutaneous melanoma. The possible tumoral regression and the immune reaction should be better perceived. [less ▲]Detailed reference viewed: 23 (7 ULg) From << An enzyme able to destroy penicillin >> to carbapenemases: 70 years of beta-lactamase misbehavior.Frère, Jean-Marie ; Sauvage, Eric ; Kerff, Frederic in Current drug targets (2015)As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They ... [more ▼]As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the beta-lactam ring. Later, an enzyme mediated by an R-factor was isolated from Enterobacteriaceae. Methicillin and cephalosporins, both very poor substrates of the S. aureus enzyme, were found to be sensitive to this new enzyme. Third generation cephalosporins appeared to solve the problem, but further enzymes were selected that exhibited extended spectra and could for instance hydrolyze cefotaxime and/or ceftazidime. The discovery of carbapenems constituted a major advance for our antimicrobial arsenal: they inactivated most of the essential penicillin binding proteins effectively and escaped the activity of nearly all known beta-lactamases. However, the metallo-beta-lactamases, which had not been recognised as a major danger before 1990, were found to act as effective carbapenemases and started to spread in a worrying way. Moreover, carbapenem-hydrolyzing enzymes were found in each of the 3 classes of active-site serine beta-lactamases. [less ▲]Detailed reference viewed: 11 (3 ULg) Extracellular peptidase hunting for improvement of protein production in plant cells and rootsLallemand, Jérôme ; Bouché, Frédéric ; Desiron, Carole et alin Frontiers in Plant Science (2015), 6(37), Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now ... [more ▼]Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now reaching the market, progress are still needed to improve plant hosts and strategies for biopharming. Targeting recombinant proteins toward the extracellular space offers several advantages in terms of protein folding and purification, but degradation events are observed, due to endogenous peptidases. This paper focuses on the analysis of extracellular proteolytic activities in two production systems: cell cultures and root-secretion (rhizosecretion), in Arabidopsis thaliana and Nicotiana tabacum. Proteolytic activities of extracellular proteomes (secretomes) were evaluated in vitro against two substrate proteins: bovine serum albumin (BSA) and human serum immunoglobulins G (hIgGs). Both targets were found to be degraded by the secretomes, BSA being more prone to proteolysis than hIgGs. The analysis of the proteolysis pH-dependence showed that target degradation was mainly dependent upon the production system: rhizosecretomes contained more peptidase activity than extracellular medium of cell suspensions, whereas variations due to plant species were smaller. Using class-specific peptidase inhibitors, serine and metallopeptidases were found to be responsible for degradation of both substrates. An in-depth in silico analysis of genomic and transcriptomic data from Arabidopsis was then performed and led to the identification of a limited number of serine and metallo-peptidases that are consistently expressed in both production systems. These peptidases should be prime candidates for further improvement of plant hosts by targeted silencing. [less ▲]Detailed reference viewed: 121 (17 ULg) Marine space ecology and seagrasses. Does patch type matter in Posidonia oceanica seascapes?Abadie, Arnaud ; Gobert, Sylvie ; Bonacorsi, Marina et alin Ecological Indicators (2015), 57The use of landscape tools in the study of seagrass meadows (seascapes) begins to be widely spreadbut still require the establishment of several basis, i.e. a patch type classification based on ... [more ▼]The use of landscape tools in the study of seagrass meadows (seascapes) begins to be widely spreadbut still require the establishment of several basis, i.e. a patch type classification based on numericalcharacteristics. Thanks to the complex seascapes created by the Posidonia oceanica meadows, they appearto be suitable for a study at a patch type level (class), which bring a new insight of their arrangement at thewhole seascape scale. By interpreting side scan sonar images from the Corsican coast (France) through aGIS software, it was possible to describe 11 types of patches and to evaluate their natural or anthropogenicorigin. Comparison of different landscape metrics and wave exposure (Relative wave Exposure Index,REI) at the seascape and the patch level showed that the particularity of P. oceanica seascapes are mainlycharacterized by certain types of patches often of anthropogenic origin. Furthermore the REI seems not tobe a relevant index for a study at a class scale. A bathymetrical succession of natural patches was outlinedfrom the lower to the upper limit of the meadow, with a long-term dynamic opposed to a shorter oneconcerning anthropogenic patches. In order to assess the origin (natural or induced by human activities)of the patches in P. oceanica meadows, as well as in any other seagrass, a Patchiness Source Index (PaSI),ranging from 0 to 1, was defined. [less ▲]Detailed reference viewed: 23 (10 ULg) Once-weekly DPP-4 inhibitors: do they meet an unmet need?Scheen, André in Lancet Diabetes & Endocrinology (2015), 3(3), 162-164Detailed reference viewed: 18 (2 ULg) Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathwayAlhosin, Mahmoud; León-González1, Antonio J.; Dandache et alin Scientific Reports (2015), 5Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an ... [more ▼]Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an anthocyanin-rich dietary bilberry extract (Antho 50) on B CLL cells from 30 patients and on peripheral blood mononuclear cells (PBMCs) from healthy subjects, and determined the underlying mechanism. Antho 50 induced concentration- and time-dependent pro-apoptotic effects in B CLL cells isolated from patients but little or no effect in PBMCs. Among the main phenolic compounds present in this bilberry extract, delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside showed the highest apoptotic effect on B CLL cells, suggesting that anthocyanins play a main role in the cytotoxic activity. Antho 50-induced apoptosis is associated with activation of caspase 3 and down-regulation of the anti-apoptotic protein UHRF1. Antho 50 induced also rapid dephosphorylation of Akt and Bad, and down-regulation of Bcl-2 resulting in reduced cell viability. Antho 50 significantly induced PEG-catalase-sensitive formation of reactive oxygen species in B CLL cells. PEG-catalase prevented the Antho 50-induced reduced cell viability, induction of apoptosis, up-regulation of caspase 3, down-regulation of UHRF1 and Bcl-2, and dephosphorylation of Bad. The present findings indicate that Antho 50 exhibits strong pro-apoptotic activity through redox-sensitive caspase 3 activation-related mechanism in B CLL cells involving dysregulation of Bad/Bcl-2 pathway. This activity is due, at least in part, to a composition rich on glucoside and rutinoside derivatives of delphinidin. They further suggest that Antho 50 has chemotherapeutic potential by targeting selectively B CLL cells. [less ▲]Detailed reference viewed: 16 (4 ULg) Trans-iron elements in the hot DO-type white dwarf RE 0503-289 and the prospective search for technetiumWerner, K; Rauch, T; Crespo Lopez-Urrutia, J R et alin The Astronomical Society of the Pacific Conference Series (2015), 493Detailed reference viewed: 17 (0 ULg) Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: a double-blind randomized controlled clinical trial.Passerieux, Emilie; Hayot, Maurice; Jaussent, Audrey et alin Free radical biology & medicine (2015), 81Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. As growing evidence suggests that oxidative ... [more ▼]Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. As growing evidence suggests that oxidative stress may contribute to FSHD pathology, antioxidants that might modulate or delay oxidative insults could help in maintaining FSHD muscle function. Our primary objective was to test whether oral administration of vitamin C, vitamin E, zinc gluconate, and selenomethionine could improve the physical performance of patients with FSHD. Adult patients with FSHD (n=53) were enrolled at Montpellier University Hospital (France) in a randomized, double-blind, placebo-controlled pilot clinical trial. Patients were randomly assigned to receive 500 mg vitamin C, 400mg vitamin E, 25mg zinc gluconate and 200 mug selenomethionine (n=26), or matching placebo (n=27) once a day for 17 weeks. Primary outcomes were changes in the two-minute walking test (2-MWT), maximal voluntary contraction, and endurance limit time of the dominant and nondominant quadriceps (MVCQD, MVCQND, TlimQD, and TlimQND, respectively) after 17 weeks of treatment. Secondary outcomes were changes in the antioxidant status and oxidative stress markers. Although 2-MWT, MVCQ, and TlimQ were all significantly improved in the supplemented group at the end of the treatment compared to baseline, only MVCQ and TlimQ variations were significantly different between groups (MVCQD: P=0.011; MVCQND: P=0.004; TlimQD: P=0.028; TlimQND: P=0.011). Similarly, the vitamin C (P<0.001), vitamin E as alpha-tocopherol (P<0.001), vitamin C/vitamin E ratio (P=0.017), vitamin E gamma/alpha ratio (P=0.022) and lipid peroxides (P<0.001) variations were significantly different between groups. In conclusion, vitamin E, vitamin C, zinc, and selenium supplementation has no significant effect on the 2-MWT, but improves MVCQ and TlimQ of both quadriceps by enhancing the antioxidant defenses and reducing oxidative stress. This trial was registered at clinicaltrials.gov (number: NCT01596803). [less ▲]Detailed reference viewed: 61 (4 ULg) The origin and control of mega-gullies in Kinshasa (D.R. Congo)Makanzu Imwangana, Fils; Vandecasteele, Ine; Trefois, Philippe et alin Catena (2015), 125This study aims to investigate the relation between mega-gully (> 5 m width) distribution and urbanization in Kinshasa (D.R. Congo), to establish what governs mega-gully location and plan form and to ... [more ▼]This study aims to investigate the relation between mega-gully (> 5 m width) distribution and urbanization in Kinshasa (D.R. Congo), to establish what governs mega-gully location and plan form and to illustrate the concepts behind mega-gully treatment. For this purpose, the diachronic distribution of mega-gullies has been mapped in Kinshasa. All mega-gullies have been reported in ArcGis 9.3 on the orthorectified SPOT 2007 image. A newly elaborated DEM enables the mega-gullies to be placed in their natural topographical context. The GIS inventory on the SPOT 2006/2007 anaglyph indicates the mega-gully situation in the high town of Kinshasa 5 years ago: 308 mega-gullies with a cumulated length of 94.7 km, a mean drainage density of 0.4 km km− 2 and an average width and depth of 17 m and 6 m respectively. On the WorldView 1 (WV1) coverage, the number of mega-gullies has more than doubled between 2007 and 2010 from 160 to 334. The study shows that mega-gullies only develop within the urbanized perimeter of the high town of Kinshasa and only 5 to 10 years after incipient urbanization. The study also indicates that neither the location, the plan form or the downslope course of mega-gullies in Kinshasa are controlled by the natural topography. Forty-three point eight percent of the mega-gullies in Kinshasa are ‘axial’, occupying urban structures which function as artificial runoff drainage lines: roads, tarred or not, with or without side-road trenches, gutters in all forms and materials from concrete to sand, also foot paths and further all artificial runoff drainage lines. The study reveals that every mega-gully is directly or indirectly induced by human activities, but that every gully also finally ends to grow after an initial phase of sudden development. Mega-gully treatment follows two principles, often combined. The first is to stop the alimentation of the mega-gully head with water. The second includes a complete stabilization of the channel and walls inside the mega-gully. This study emphasizes that gully prevention can basically be achieved by control of the runoff discharges in the artificial stream network, as well as beside the roads. [less ▲]Detailed reference viewed: 46 (9 ULg) Le pouvoir par les armes, le pouvoir par les idéesDumont, Jonathan ; Masson, Christophe in Moyen Age (Le) (2015), CXXI(I), Ouverte à des questions que seulement quelques décennies auparavant elle peinait à envisager, l'histoire politique ou l'histoire du/des pouvoir(s) n'est plus uniquement aujourd'hui une étude des ... [more ▼]Ouverte à des questions que seulement quelques décennies auparavant elle peinait à envisager, l'histoire politique ou l'histoire du/des pouvoir(s) n'est plus uniquement aujourd'hui une étude des structures administratives et judiciaires, ou encore des événements dits "politiques". Elle fait, tout au contraire, la part belle à des dynamiques de recherche interdisciplinaire. L'étude croisée du fait militaire et des idées est l'une d'entre elles. Le présent recueil d'articles, "Le pouvoir par les armes. Le pouvoir par les idées", se positionne dans la continuité des recherches récentes en la matière. Il entend, en particulier, se concentrer sur les liens que les hommes et les femmes de la fin du Moyen Âge établirent entre l'action armée et les discours sur le pouvoir. C'est en effet à travers les interconnexions de ces deux champs que l'on peut mieux comprendre le succès ou l'insuccès d'une politique - militaire ou non - ou l'émergence d'une propagande justifiant un pouvoir et, parfois, le recours aux armes. Ce volume entend ainsi contribuer à éclairer la manière dont émerge, se construit et s'affirme les différents pouvoirs au Moyen Âge tardif et au cours de la première Renaissance. [less ▲]Detailed reference viewed: 41 (10 ULg) Size and porosity effects on thermal conductivity of nanoporous material with an extension to nanoporous particles embedded in a host matrixMachrafi, Hatim ; Lebon, Georgy in Physics Letters A (2015), 379Detailed reference viewed: 23 (6 ULg) a retrospective serological survey on human babesiosis in BelgiumLempereur, Laetitia ; Shiels, Brian; Saegerman, Claude et alin Clinical Microbiology and Infection (2015), 21(1), Detailed reference viewed: 20 (0 ULg) Is Dysfunctional use of the Mobile Phone a Behavioural addiction? Confronting Symptom-Based Versus Process-based ApproachesBillieux, Joël; Philippot, Pierre; Schmid, Cécile et alin Clinical Psychology & Psychotherapy (2015)Detailed reference viewed: 20 (2 ULg) International assessment of future low flow regimes and their impact on three water related sectors in the Meuse basin – a collaborative approachBauwens, Alexandra; Degré, Aurore ; Deraedt, Deborah et alin International Journal of River Basin Management (2015), 13(1), 123-135There is a wide recognition of the watershed scale as the right scale for global water management, notably in the context of the WFD. Hence, it often refers to international management and therefore to ... [more ▼]There is a wide recognition of the watershed scale as the right scale for global water management, notably in the context of the WFD. Hence, it often refers to international management and therefore to various pre-existing regional management tools, models or even objectives. In this study we aim at describing the collaborative assessment of climate change’s effect on low flow regime and the consequences on three water related sectors: drinking water production, agriculture and electricity production. The paper highlights the choices that were made during the study that involved scientific teams, managers and stakeholders from the four main countries of the Meuse Basin. It shows that the methodological choices were operational and aimed at preserving existing methods and knowledge within each country. They led to hydrological scenarios comparable to the main available ensemble approaches and to methodologies well accepted within the concerned countries. The results of the project highlight and quantify the water scarcity that the three sectors will have to face by the end of the century mainly regarding the electricity production. They also show that common allocation rules are necessary to manage water demand during future low flow periods. [less ▲]Detailed reference viewed: 53 (12 ULg) Test-positive rate at CT colonography is increased by rectal bleeding and/orunexplained weight loss, unlike other common gastrointestinal symptomsHock, Danielle; MATERNE, Roland; Ouhadi, Roxanne et alin European Journal of Radiology (2015), 22015AbstractPurpose: We evaluated the rate of significant colonic and extra-colonic abnormalities at computed tomography colonography (CTC), accordingto symptoms and age.Materials and methods: We ... [more ▼]2015AbstractPurpose: We evaluated the rate of significant colonic and extra-colonic abnormalities at computed tomography colonography (CTC), accordingto symptoms and age.Materials and methods: We retrospectively evaluated 7361 consecutive average-risk subjects (3073 males, average age: 60.3 ± 13.9; range 18–96years) for colorectal cancer (CRC) who underwent CTC. They were divided into three groups according to clinical symptoms: 1343 asymptomaticindividuals (group A), 899 patients with at least one “alarm” symptom for CRC, including rectal bleeding and unexplained weight loss (groupC), and 5119 subjects with other gastrointestinal symptoms (group B). Diagnostic and test-positive rates of CTC were established using opticalcolonoscopy (OC) and/or surgery as reference standard. In addition, clinically significant extra-colonic findings were noted.Results: 903 out of 7361 (12%, 95% confidence interval (CI) 0.11–0.13) subjects had at least one clinically significant colonic finding at CTC. CTCtrue positive fraction and false positive fraction were respectively 637/642 (99.2%, 95%CI 0.98–0.99) and 55/692 (7.95%, 95%CI 0.05–0.09). Thepooled test-positive rate in group C (138/689, 20.0%, 95%CI 0.17–0.23) was significantly higher than in both groups A (79/1343, 5.9%, 95%CI0.04–0.07) and B (420/5329, 7.5%, 95%CI 0.07–0.08) (p < 0.001). Aging and male gender were associated to a higher test positive rate. The rateof clinically significant extra-colonic findings was significantly higher in group C (44/689, 6.4%, 95%CI 0.04–0.08) versus groups A (26/1343,1.9%, 95%CI 0.01–0.02) and B (64/5329, 1.2%, 95%CI 0.01–0.02) (p < 0.001).Conclusion: Both test-positive and significant extra-colonic finding rates at CTC are significantly increased in the presence of “alarm” gastroin-testinal symptoms especially in older patients. [less ▲]Detailed reference viewed: 18 (5 ULg) Glioblastoma Circulating Cells: Reality, Trap or Illusion?LOMBARD, Arnaud ; Goffart, Nicolas ; Rogister, Bernard in Stem Cells International (2015)Detailed reference viewed: 23 (1 ULg) Importance of structural damping in the dynamic analysis of compliant deployable structuresDewalque, Florence ; Rochus, Pierre ; Bruls, Olivier in Acta Astronautica (2015), 111Compliant mechanisms such as tape springs are often used on satellites to deploy appendices, e.g. solar panels, antennas, telescopes and solar sails. Their main advantage comes from the fact that their ... [more ▼]Compliant mechanisms such as tape springs are often used on satellites to deploy appendices, e.g. solar panels, antennas, telescopes and solar sails. Their main advantage comes from the fact that their motion results from the elastic deformation of structural components, unlike usual hinges or prismatic joints, the motion of which is dictated by contact surfaces. No actuators or external energy sources are required and the deployment is purely passive, which appears as a decisive feature for the design of low-cost missions with small satellites or cubesats. The mechanical behaviour of a tape spring is intrinsically complex and nonlinear involving buckling, hysteresis and self-locking phenomena. High-ﬁdelity mechanical models are then needed to get a detailed understanding of the deployment process, improve the design and predict the actual behaviour in the space 0-g environment. In the majority of the previous works, dynamic simulations were performed without any physical representation of the structural damping. These simulations could be successfully achieved because of the presence of numerical damping in the transient solver. However, in this case, the dynamic response turns out to be quite sensitive to the amount of numerical dissipation, so that the predictive capabilities of the model are questionable. In this work based on numerical case studies, we show that the dynamic simulation of a tape spring can be made less sensitive to numerical parameters when the structural dissipation is taken into account. [less ▲]Detailed reference viewed: 51 (7 ULg) Microanatomy of the cervical and anorectal squamocolumnar junctions: a proposed model for anatomical differences in HPV-related cancer riskYang, Eric J; Quick, Charles M; Hanamornroongruang, Suchanan et alin Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2015), 28Detailed reference viewed: 12 (0 ULg) Trophodynamics of estuarine intertidal harpacticoid copepods based on stable isotope composition and fatty acid profilesCnudde, Clio; Moens, Tom; Werbrouck, Eva et alin Marine Ecology. Progress Series (2015), 524Trophic interactions at the basis of food webs, for instance between meiofauna, primary producers and bacteria, are key drivers of benthic energy fluxes. Yet both qualitative and quantitative information ... [more ▼]Trophic interactions at the basis of food webs, for instance between meiofauna, primary producers and bacteria, are key drivers of benthic energy fluxes. Yet both qualitative and quantitative information about meiofaunal resource utilization under in situ conditions is scant. By means of natural stable isotope ratios of carbon and nitrogen and of fatty acid (FA) profiles, we examined the variability of in situ resource utilization of a range of harpacticoid copepod species from 5 stations in an estuarine intertidal area. These stations, located in different habitats, differed in sediment granulometry, resource availability, presence/absence of vegetation and other environmental variables, as well as in copepod species composition. Our goal was to describe inter-specific differences among harpacticoid species, as well as spatio-temporal variability within species. Despite differences in resource availability between habitats, δ13C data clearly point at microphytobenthos (MPB) as the major carbon source to the harpacticoid assemblages at all 5 stations. Small differences in carbon isotopic ratios between co-occurring species indicate some degree of resource differentiation, whereas both the δ15N and FA composition suggest that several harpacticoid species obtain MPB carbon indirectly, perhaps through feeding on bacteria or ciliates. For a limited number of species, such as Paraleptastacus spinicauda, clear dietary contributions of suspended particulate matter and bacteria were found, and MPB appeared to have only a small or no contribution. Even in vegetated salt-marsh stations, Spartina anglica detritus did not appear to contribute to copepod diets. The δ13C of Cletodidae were highly depleted, reflecting a contribution of methane-derived carbon. [less ▲]Detailed reference viewed: 59 (2 ULg) Farmers' practices and willingness to adopt supplemental irrigation in Burkina FasoZongo, Bétéo ; Diarra, Abdoulaye; Barbier, Bruno et alin International Journal of Food and Agricultural Economics (2015), 3(1), 101-117This study analyzes farmers' practices and willingness to adopt supplemental irrigation on rainfed crops in the Sahelian and Sudano-Sahelian areas of Burkina Faso. A survey of 629 farmers revealed a ... [more ▼]This study analyzes farmers' practices and willingness to adopt supplemental irrigation on rainfed crops in the Sahelian and Sudano-Sahelian areas of Burkina Faso. A survey of 629 farmers revealed a diversity of farming practices within and between two agro-climatic zones. Over 65% of farmers believe that supplemental irrigation is a good way to mitigate the adverse effects of dry spells on crop yields. Determining factors of farmers’ willingness to adopt supplemental irrigation were identified using a logistic model. Lack of information is the major obstacle to promoting this innovation. Farmers’ training and information dissemination are the best ways to increase the acceptance of this promising technology. [less ▲]Detailed reference viewed: 50 (13 ULg) Drying of alga as a source of bioenergy feedstock and food supplement - A reviewBennamoun, Lyes; Afzal, Muhammad. T.; Léonard, Angélique in Renewable & Sustainable Energy Reviews (2015), 50Detailed reference viewed: 27 (2 ULg) Added value of a triaxial accelerometer assessing gait parameters to predict falls and mortality among nursing home residents: A two-year prospective study.Buckinx, Fanny ; Beaudart, Charlotte ; Slomian, Justine et alin Technology and health care : official journal of the European Society for Engineering and Medicine (2015), 23BACKGROUND: Gait impairment seems to be a risk factor for falls and mortality. Because gait change cannot be determined easily with classical clinical tests, some authors have suggested that it might be ... [more ▼]BACKGROUND: Gait impairment seems to be a risk factor for falls and mortality. Because gait change cannot be determined easily with classical clinical tests, some authors have suggested that it might be useful to use a gait-analysis system among elderly community-dwelling people. OBJECTIVE: The main objective of the present study was to determine the predictive value of a quantitative evaluation of the gait characteristics in nursing home residents for the occurrence of falls and death performed using a tri-axial accelerometer (Locometrix(R)). MATERIAL AND METHODS: One hundred elderly nursing home residents (80 women and 20 men, mean age 86.4 +/- 6.04 years) were included in this study with the aim to follow them for 2 years. Deaths and falls were systematically recorded. A quantitative evaluation of a 10-second walk was performed with a tri-axial accelerometer (Locometrix(R)). Demographic data (i.e age, sex, body mass index) and clinical data (i.e. fall risk evaluated by the Tinetti test) were also recorded. RESULTS: During the two years of follow-up, 27 patients died. After adjustment on all potential confounding variables, only body mass index was significantly associated with the risk of mortality with an odds ratio of 0.86 (95% CI: 0.77-0.96, p=0.04). At the end of the study period, 440 falls had occurred (mean: 4.44 +/- 6.79 falls per patient) but no single factors were independently associated with fall incidence. CONCLUSION: Our results show that a quantitative gait analysis performed using a tri-axial accelerometer is not predictive of long-term falls and mortality among nursing home residents. [less ▲]Detailed reference viewed: 19 (16 ULg) a phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periodsBruyère, Olivier ; DEROISY, Rita ; Dardenne, Nadia et alin Osteoporosis International (2015)Summary In a randomized, cross-over study, once monthly administration of vitamin D3 was preferred over a once daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better ... [more ▼]Summary In a randomized, cross-over study, once monthly administration of vitamin D3 was preferred over a once daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better compliance but without any significant difference in the increase in vitamin D levels. Introduction The aim of the present study was to compare a once-monthly administration of vitamin D3 to a daily administration of a fixed-dose combination of vitamin D3 and calcium during two treatment periods of 6 months. Methods One hundred volunteers aged 50 years old or older were randomized to receive either one drinkable ampoule containing 25,000 IU vitamin D3 (D-Cure®, SMB) once monthly (group VD) or one chewable tablet containing 1000 mg calcium carbonate+800 IU vitamin D3 (Steovit Forte®, Takeda) once daily (group VDCa) during 6 months. After the first 6 months of treatment, the groups were reversed according to the randomized cross-over design. Treatment compliance (i.e. the primary outcome), preference, acceptability and vitamin D levels and adverse events were all collected. Results For the two periods, the patients had a significantly higher compliance in the VD group than in the VDCa group (p<0.0001). During the study, 50 (56.8 %) patients preferred the VD treatment, 16 (18.2 %) patients preferred the VDCa, and for 22 (25.0 %) patients, neither treatment was preferred. At the end of the first 6 months of treatment, the mean (SD) increase of 25(OH)D was 6.57 ng/mL (8.19) in the VD group and 3.88 ng/mL (10.0) in the VDCa group (p=0.16 between groups). Conclusion In this study, a once-monthly administration of vitamin D3 was preferred over a once-daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better compliance but without any significant difference in the increase in vitamin D levels. [less ▲]Detailed reference viewed: 38 (11 ULg) Bioaccumulation of organohalogenated compounds in sharks and rays from the southeastern USAWeijs, Liesbeth; Briels, Nathalie; Adams, Douglas et alin Environmental Research (2015), 137Organohalogenated compounds are widespread in the marine environment and can be a serious threat to organisms in all levels of aquatic food webs, including elasmobranch species. Information about the ... [more ▼]Organohalogenated compounds are widespread in the marine environment and can be a serious threat to organisms in all levels of aquatic food webs, including elasmobranch species. Information about the concentrations of POPs (persistent organic pollutants) and of MeO-PBDEs (methoxylated polybrominated diphenyl ethers) in elasmobranchs is scarce and potential toxic effects are poorly understood. The aims of the present study were therefore to investigate the occurrence of multiple POP classes (PCBs, PBDEs, DDXs, HCB, CHLs) and of MeO-PBDEs in various elasmobranch species from different trophic levels in estuarine and marine waters of the southeastern United States. Overall, levels and patterns of PCBs, PBDEs, DDXs, HCB, CHLs and of MeO-PBDEs varied according to the species, maturity stage, gender and habitat type. The lowest levels of POPs were found in Atlantic stingrays and the highest levels were found in bull sharks. As both species are respectively near the bottom and at top of the trophic web, with juvenile bull sharks frequently feeding on Atlantic stingrays, these findings further suggest a bioaccumulation and biomagnification process with trophic position. MeO-PBDEs were not detected in Atlantic stingrays, but were found in all shark species. HCB was not found in Atlantic stingrays, bonnetheads or lemon sharks, but was detected in the majority of bull sharks examined. Comparison with previous studies suggests that Atlantic stingrays may be experiencing toxic effects of PCBs and DDXs on their immune system. However, the effect of these compounds on the health of shark species remains unclear. [less ▲]Detailed reference viewed: 32 (15 ULg) Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.Harvey, N. C.; Gluer, C. C.; Binkley, N. et alin Bone (2015), 78Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures ... [more ▼]Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX(R) algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g. diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX. [less ▲]Detailed reference viewed: 22 (9 ULg) Detection of differential item functioning using the lasso approachMagis, David ; Tuerlinckx, Francis; De Boeck, Paulin Journal of Educational & Behavioral Statistics (2015), 40This paper proposes a novel approach to detect differential item functioning (DIF) among dichotomously scored items. Unlike standard DIF methods that perform an item-by-item analysis, we propose the “LR ... [more ▼]This paper proposes a novel approach to detect differential item functioning (DIF) among dichotomously scored items. Unlike standard DIF methods that perform an item-by-item analysis, we propose the “LR lasso DIF method”: logistic regression (LR) model is formulated for all item responses. The model contains item specific intercepts, an effect of the sum score and item-group interaction (i.e. DIF) effects, with a lasso penalty on all DIF parameters. Optimal penalty parameter selection is investigated through several known information criteria (AIC, BIC and cross-validation) as well as through a newly developed alternative. A simulation study was conducted to compare the global performance of the suggested “LR lasso DIF” method to the logistic regression and Mantel-Haenszel methods (in terms of false alarm and hit rates). It is concluded that for small samples the LR lasso DIF approach globally outperforms the logistic regression method, and also the Mantel-Haenszel method, especially in the presence of item impact, while it yields similar results with larger samples. [less ▲]Detailed reference viewed: 60 (3 ULg) Allogeneic hematopoietic stem cell transplantation in solid organ transplant recipients: a retrospective, multicenter study of the EBMTBasak, GW.; Wiktor-Jedrzejczak, W.; Labopin, M. et alin American Journal of Transplantation (2015), 15We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in ... [more ▼]We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in recipients of solid organ transplantation (SOT). We investigated 28 patients with malignant (N=22) or nonmalignant diseases (N=6), who underwent 31 alloSCT procedures: 12 after kidney, 13 after liver, and three after heart transplantation. The incidence of solid organ graft failure at 60 months after first alloSCT was 33% (95% confidence interval [CI], 16–51%) for all patients, 15% (95% CI, 2–40%) for liver recipients, and 50% (95% CI, 19–75%) for kidney recipients (p = 0.06). The relapse rate after alloSCT (22%) was low following transplantation for malignant disorders, despite advanced stages of malignancy. Overall survival at 60 months after first alloSCT was 40% (95% CI, 19–60%) for all patients, 51% (95% CI, 16–86%) for liver recipients, and 42% (95% CI, 14–70%) for kidney recipients (p = 0.39). In summary, we show that selected SOT recipients suffering from hematologic disorders may benefit from alloSCT and experience enhanced long-term survival without loss of organ function. [less ▲]Detailed reference viewed: 21 (0 ULg) Local modulation of steroid action: rapid control of enzymatic activity.Charlier, Thierry D.; Cornil, Charlotte ; Patte-Mensah, Christine et alin Frontiers in neuroscience (2015), 9Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects ... [more ▼]Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects should be associated with rapid modulations of estrogens concentrations. 17beta-estradiol is synthesized by the enzyme aromatase, using testosterone as a substrate, but can also be degraded into catechol-estrogens via hydroxylation by the same enzyme, leading to an increase or decrease in estrogens concentration, respectively. The first evidence that aromatase activity (AA) can be rapidly modulated came from experiments performed in Japanese quail hypothalamus homogenates. This rapid modulation is triggered by calcium-dependent phosphorylations and was confirmed in other tissues and species. The mechanisms controlling the phosphorylation status, the targeted amino acid residues and the reversibility seem to vary depending of the tissues and is discussed in this review. We currently do not know whether the phosphorylation of the same amino acid affects both aromatase and/or hydroxylase activities or whether these residues are different. These processes provide a new general mechanism by which local estrogen concentration can be rapidly altered in the brain and other tissues. [less ▲]Detailed reference viewed: 110 (0 ULg) Compte rendu de l'ouvrage d'I. Mazzini, Letteratura e medicina nel mondo antico, Rome: Università La Sapienza, 2011Ricciardetto, Antonio in Latomus : Revue d'Etudes Latines (2015), 74(1), 280-282Detailed reference viewed: 61 (17 ULg) First evidence of Devonian strata in sweden? - a palynological investigation of Övedskloster drillcores 1 and 2, Skåne, SwedenMehlqvist, K; Vajda, V.; Steemans, Philippe in Geological Magazine (2015), 221Detailed reference viewed: 14 (1 ULg) Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.Garcia-Gonzalo, F. R.; Phua, S. C.; Roberson, E. C. et alin Developmental Cell (2015), 34Primary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for signaling is unclear. One possibility is that some forms of signaling require a distinct membrane lipid composition ... [more ▼]Primary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for signaling is unclear. One possibility is that some forms of signaling require a distinct membrane lipid composition, found at cilia. We found that the ciliary membrane contains a particular phosphoinositide, PI(4)P, whereas a different phosphoinositide, PI(4,5)P2, is restricted to the membrane of the ciliary base. This distribution is created by Inpp5e, a ciliary phosphoinositide 5-phosphatase. Without Inpp5e, ciliary PI(4,5)P2 levels are elevated and Hh signaling is disrupted. Inpp5e limits the ciliary level s of inhibitors of Hh signaling, including Gpr161 and the PI(4,5)2-binding protein Tulp3. Increasing ciliary PI(4,5)P2levels or conferring the ability to bind PI(4)P on Tulp3 increases the ciliary localization of Tulp3. Lowering Tulp3 in cells lacking Inpp5e [less ▲]Detailed reference viewed: 23 (3 ULg) BMP Signaling Regulates Bone Morphogenesis in Zebrafish through Promoting Osteoblast Function as Assessed by Their Nitric Oxide ProductionWindhausen, Thomas ; Squifflet, Steeve; Renn, Jörg et alin Molecules (2015), 20Bone morphogenetic proteins (BMPs) control many developmental and physiological processes, including skeleton formation and homeostasis. Previous studies in zebrafish revealed the crucial importance of ... [more ▼]Bone morphogenetic proteins (BMPs) control many developmental and physiological processes, including skeleton formation and homeostasis. Previous studies in zebrafish revealed the crucial importance of proper BMP signaling before 48 h post-fertilization (hpf) for cartilage formation in the skull. Here, we focus on the involvement of the BMP pathway between 48 and 96 hpf in bone formation after 96 hpf. Using BMP inhibitors and the expression of a dominant-negative BMP receptor, we analyze whether the loss of BMP signaling affects osteoblastogenesis, osteoblast function and bone mineralization. To this end, we used the transgenic zebrafish line Tg(osterix:mCherry), detection of nitric oxide (NO) production, and alizarin red staining, respectively. We observed that inhibition of BMP signaling between 48 and 72 hpf led to a reduction of NO production and bone mineralization. Osteoblast maturation and chondrogenesis, on the other hand, seemed unchanged. Osteoblast function and bone formation were less affected when BMP signaling was inhibited between 72 and 96 hpf. These results suggest that for the onset of bone formation, proper BMP signaling between 48 and 72 hpf is crucial to ensure osteoblast function and ossification. Furthermore, detection of NO in developing zebrafish larvae appears as an early indicator of bone calcification activity. [less ▲]Detailed reference viewed: 20 (12 ULg) Cardiovascular imaging practice in Europe: a report from the European Association of Cardiovascular Imaging.Lancellotti, Patrizio ; Plonska-Gosciniak, Edyta; Garbi, Madalina et alin European heart journal cardiovascular Imaging (2015), 16(7), 697-702The need for cardiovascular imaging (CVI) is expected to increase over the coming years due to the changes in CV disease epidemiology and ageing of the population. However, reliable statistics on CVI ... [more ▼]The need for cardiovascular imaging (CVI) is expected to increase over the coming years due to the changes in CV disease epidemiology and ageing of the population. However, reliable statistics on CVI practice in Europe are lacking. Establishing the current status of the use of CVI across Europe has become the first comprehensive project of the European Association of Cardiovascular Imaging and the European Society of Cardiology Taskforce on CVI. In 2013, a survey with relevant information regarding CVI was sent to all National Imaging/Echocardiography Societies and Working Groups. Representatives from 41 countries returned the questionnaire. The present report provides key results of the survey, relating to existing education, training, certification and national accreditation programmes, healthcare organizations, and reimbursement systems. [less ▲]Detailed reference viewed: 18 (1 ULg) Du « compagnonnage de route » à la « fin du mandat ». Une réflexion sur les intellectuels entre Sartre et FortiniCavazzini, Andrea in Année Sartrienne (L') (2015)Detailed reference viewed: 17 (1 ULg) Socioeconomic impact on the prevalence of cardiovascular risk factors in Wallonia, Belgium: a population based-studyStreel, Sylvie ; Donneau, Anne-Françoise ; Hoge, Axelle et alin BioMed Research International (2015)Detailed reference viewed: 39 (11 ULg) Characterization of Cichopeptins, New Phytotoxic Cyclic Lipodepsipeptides Produced by Pseudomonas cichorii SF1-54, and Their Role in Bacterial Midrib Rot Disease of LettuceHuang, CJ; Pauwelyn, E.; Ongena, Marc et alin Molecular Plant-Microbe Interactions [=MPMI] (2015), 28(9), 109-1022Detailed reference viewed: 23 (7 ULg) Uncertainty in training image-based inversion of hydraulic head data constrained to ERT data: workflow and case studyHermans, Thomas ; Nguyen, Frédéric ; Caers, Jefin Water Resources Research (2015), 51In inverse problems, investigating uncertainty in the posterior distribution of model parameters is as important as matching data. In recent years, most efforts have focused on techniques to sample the ... [more ▼]In inverse problems, investigating uncertainty in the posterior distribution of model parameters is as important as matching data. In recent years, most efforts have focused on techniques to sample the posterior distribution with reasonable computational costs. Within a Bayesian context, this posterior depends on the prior distribution. However, most of the studies ignore modeling the prior with realistic geological uncertainty. In this paper, we propose a workflow inspired by a Popper-Bayes philosophy, that data should first be used to falsify models, then only be considered for matching. We propose a workflow consisting of three steps: (1) in defining the prior, we interpret multiple alternative geological scenarios from literature (architecture of facies) and site specific data (proportions of facies). Prior spatial uncertainty is modeled using multiple-point geostatistics, where each scenario is defined using a training image. (2) We validate these prior geological scenarios by simulating electrical resistivity tomography (ERT) data on realizations of each scenario and comparing them to field ERT in a lower dimensional space. In this second step, the idea is to probabilistically falsify scenarios with ERT, meaning that scenarios which are incompatible receive an updated probability of zero while compatible scenarios receive a non-zero updated belief. (3) We constrain the hydrogeological model with hydraulic head and ERT using a stochastic search method. The workflow is applied to a synthetic and a field case studies in an alluvial aquifer. This study highlights the importance of considering and estimate prior uncertainty (without data) through a process of probabilistic falsification. [less ▲]Detailed reference viewed: 20 (9 ULg) Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological SocietyBaron, Frédéric ; Zachée, Pierre; Maertens, Johan et alin Journal of Hematology & Oncology (2015), 8(4), 10118613045-014-0098-9Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the ... [more ▼]Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n = 49) or 8 Gy TLI + anti-thymocyte globulin (TLI-ATG arm; n = 45) conditioning. Results: The 180-day cumulative incidences of grade II-IV acute GVHD (primary endpoint) were 12.2% versus 8.9% in Flu-TBI and TLI-ATG patients, respectively (P = 0.5). Two-year cumulative incidences of moderate/severe chronic GVHD were 40.8% versus 17.8% in Flu-TBI and TLI-ATG patients, respectively (P = 0.017). Five Flu-TBI patients and 10 TLI-ATG patients received pre-emptive DLI for low donor chimerism levels, while 1 Flu-TBI patient and 5 TLI-ATG patients (including 2 patients given prior pre-emptive DLIs) received a second HCT for poor graft function, graft rejection, or disease progression. Four-year cumulative incidences of relapse/progression were 22% and 50% in Flu-TBI and TLI-ATG patients, respectively (P = 0.017). Four-year cumulative incidences of nonrelapse mortality were 24% and 13% in Flu-TBI and TLI-ATG patients, respectively (P = 0.5). Finally, 4-year overall (OS) and progression-free survivals (PFS) were 53% and 54%, respectively, in the Flu-TBI arm, versus 54% (P = 0.9) and 37% (P = 0.12), respectively, in the TLI-ATG arm. Conclusions: In comparison to patients included in the Flu-TBI arm, patients included in the TLI-ATG arm had lower incidence of chronic GVHD, higher incidence of relapse and similar OS. [less ▲]Detailed reference viewed: 24 (15 ULg) A Stereocontrolled Synthesis of the Hydrophobic Moiety of RhamnolipidsMenhour, Boudjema; Mayon, Patrick; Plé, Karen et alin Tetrahedron Letters (2015), 56Detailed reference viewed: 40 (3 ULg) Information behaviour of French-speaking speech–language therapists in Belgium: results of a questionnaire surveyDurieux, Nancy ; Pasleau, Françoise ; Piazza, Aurélie et alin Health Information andLibraries Journal (2015)BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study ... [more ▼]BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study was to explore Belgian French-speaking SLTs’ information behaviour and their awareness of EBP. The collected data allow one to determine how far they have embraced this approach. METHODS: The two Belgian French-speaking SLT professional associations promoted an online questionnaire survey by email. Additionally, clinical supervisors of students were asked to participate. In March 2012, 2068 emails were sent. RESULTS: The participation rate was at least 20% (n = 415). The reported information needs mainly concerned treatment or diagnosis. Most of the time, to attempt to fulfil their information needs, SLTs relied on their own resources (personal experience and libraries) and on colleagues in the workplace. When they searched on the Internet, they preferred to use a general search engine rather than a specialised bibliographic database. Barriers to obtaining scientific information are highlighted. Only 12% of the respondents had already heard about EBP. CONCLUSION: This study provides the first overview of the information behaviour of SLTs working in the French community of Belgium. Several recommendations are suggested for SLTs and librarians. [less ▲]Detailed reference viewed: 27 (6 ULg) Identification of Mistuning and Model Updating of an Academic Blisk Based on Geometry and Vibration MeasurementsNyssen, Florence ; Golinval, Jean-Claude in Mechanical Systems & Signal Processing (2015)In this work, an experimental modal analysis is performed on an academic bladed disk using a base excitation to identify the mistuning of each blade. Optical measurement is used to obtain the exact ... [more ▼]In this work, an experimental modal analysis is performed on an academic bladed disk using a base excitation to identify the mistuning of each blade. Optical measurement is used to obtain the exact geometry of the structure and to be able to associate geometrical mistuning to each blade. Differences are observed between the experimentally identified mistuning and the geometrical mistuning. Since the bladed disk is a one-piece structure, there are no welded connections between the blades and the disk and the material properties can be assumed to be uniform. It can be shown that these differences come from nonuniform clamping conditions, and that this mistuning is of the same order of magnitude than the variations in the geometry of the structure. It follows that the precise characterisation of mistuning for industrial structures is in practice illusory because of the numerous factors introducing mistuning, such as the clamping conditions, aerodynamic damping, wear in service, etc. [less ▲]Detailed reference viewed: 11 (1 ULg) Multiple timescale spectral analysisDenoël, Vincent in Probabilistic Engineering Mechanics (2015), 39(0), 69--86Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the ... [more ▼]Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the steady-state second order cumulant of a linear oscillator, under the action of a stationary loading prescribed by means of its power spectral density. There exists however a broad variety of such similar problems, extending the concept to multi degree-of-freedom systems, non Gaussian excitation, slightly nonlinear oscillators or even transient excitations. In this wide class of problems, the cumulants of the response are obtained as the result of the integral of corresponding spectra over the frequency space, which is possibly multidimensional. Application of standard numerical integration techniques may be prohibitive, a reason why the spectral approach is often left aside. Besides, many engineering problems involve a clear timescale separation, usually of those pertaining to the loading and to the mechanical behavior of the system. In these problems, a proper consideration of the timescale separation results in dropping the order of integration by one, at least. This offers the possibility to derive analytical solutions, whenever the order of integration drops to zero, or to make numerical integration competitive. The paper presents this general method, together with some applications in wind and marine engineering. [less ▲]Detailed reference viewed: 15 (5 ULg)