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See detailLandscape cultivation alters d30Si signature in terrestrial ecosystems
Vandevenne, F; Delvaux, C; Hughes, H et al

in Scientific Reports (2015)

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See detailSedimentary development and magnetic susceptibility evolution of the Frasnian in Western Belgium (Dinant Synclinorium, La Thure section)
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Develeeschouwer, Xavier et al

in Special Publication - Geological Society of London (2015), 414

Recent opening of the La Thure quarry in Western Belgium allowed the collection of new data from a poorly outcropping area of the Belgian Frasnian platform. The studied section covers an interval ... [more ▼]

Recent opening of the La Thure quarry in Western Belgium allowed the collection of new data from a poorly outcropping area of the Belgian Frasnian platform. The studied section covers an interval extending from thefalsiovalis to hassi s.l. Zones. Sedimentological analyses allowed the reconstruction of depositional settings in the northwestern part of the Dinant Synclinorium after the demise of the extended Givetian carbonate platform. Two depositional models are distinguished: (a) siliciclastic drowned platform during the Early Frasnian; and (b) a forereef depositional setting belonging to a rimmed shelf during the Middle Frasnian. Moreover, interpreted depositional settings in the northwestern part of the Dinant Synclinorium allowed to constraint the direction of the main facies belts for the Belgian Frasnian platform. Combination of MS and geochemistry demonstrates the inherent-parallel link existing between variation in MS values and proxy for terrestrial input (such as Si and Al). This observation means that, despite the remagnetization occurring within the Belgian Frasnian lithologies, the main trends in the MS signal from the La Thure section still reflect some syn-sedimentary conditions. The increase in MS and clastic input proxies recorded in distal fore-reef deposit within the punctata Zone are likely to be considered as enhanced by rapid and strong shallowing events recognized in the ‘puncataEvent’ interval. [less ▲]

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See detailEchocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study.
Caballero, Luis; Kou, Seisyou; DULGHERu et al

in European heart journal cardiovascular Imaging (2015)

AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study ... [more ▼]

AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 +/- 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was obtained from all subjects following predefined protocols. The majority of the Doppler diastolic parameters (e', E/e') as well as right ventricle systolic s' wave velocity were similar in men and women. Left ventricle s' wave velocity was higher in men than in women. E wave and e' were higher in younger subjects and decreased progressively in the older ones. E/e' ratio increased with ageing. Septal e' <8 cm/s was present in 19.7% of the subjects in the 40-60 year group and in 55% of those in the >/=60 year group. However, the cut-off value of average E/e' or lateral E/e' remained <15 or 13, respectively, in the majority of patients. CONCLUSION: The NORRE study provides the reference values for the most useful Doppler parameters in the evaluation of heart physiology. These data highlight the need of using age-specific reference values especially for the diagnosis of LV systolic and diastolic dysfunction and for the estimation of LV filling pressures. [less ▲]

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See detailThe astronomical calibration of the Givetian (Middle Devonian) timescale (Dinant Synclinorium, Belgium)
De Vleeschouwer, David; Boulvain, Frédéric ULg; Da Silva, Anne-Christine ULg et al

in Special Publication - Geological Society of London (2015), 414

Recent advances in radiometric dating result in significant improvements in the geological timescale and provide better insight into the timing of various processes and evolutions within the Earth’s ... [more ▼]

Recent advances in radiometric dating result in significant improvements in the geological timescale and provide better insight into the timing of various processes and evolutions within the Earth’s system. However, no radiometric ages are contained within the Givetian. Consequently, the absolute ages of the Givetian Stage boundaries, as well as the stage’s duration, remain poorly constrained. As an alternative, the analysis of sedimentary cycles allows for the estimation of the duration of this stage. We examined the high-resolution magnetic susceptibility signals of four Givetian outcrops in the Givet area for a possible astronomical imprint, to fully understand the rates of evolutionary and environmental change. All four sections are firmly correlated and wavelet analyses of the magnetic susceptibility signals reveal the imprint of astronomical eccentricity forcing. The highly stable 405 kyr cycles constrain the duration of the Givetian Stage at 4.35+0.45 Myr, which is in good agreement with the International Chronostratigraphic Chart (5.0 Myr). The studied sections also exhibit an imprint of obliquity, suggesting a climatic teleconnection between low and high latitudes. The corresponding microfacies curves demonstrate similar astronomical imprint, and thereby indicate that the observed 10 5year-scale cyclicity is the result of climatic and environmental change [less ▲]

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See detailAntidiabetic agents: Potential anti-inflammatory activity beyond glucose control.
Scheen, André ULg; Esser, N.; Paquot, Nicolas ULg

in Diabetes & metabolism (2015)

A growing body of evidence is emerging to show that abdominal obesity, the metabolic syndrome, type 2 diabetes, cardiovascular disease and microvascular diabetic complications are intimately related to ... [more ▼]

A growing body of evidence is emerging to show that abdominal obesity, the metabolic syndrome, type 2 diabetes, cardiovascular disease and microvascular diabetic complications are intimately related to chronic inflammation. These observations pave the way to the development of new pharmacological strategies that aim to reduce silent inflammation. However, besides specific anti-inflammatory agents, glucose-lowering medications may also exert anti-inflammatory effects that could contribute to improved outcomes in diabetic patients. Most studies have used metformin, an AMP-activated protein kinase (AMPK) activator, and thiazolidinediones (TZDs), which act as peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists. Both pharmacological classes (considered insulin-sparing agents or insulin sensitizers) appear to have greater anti-inflammatory activity than insulin-secreting agents such as sulphonylureas or glinides. In particular, TZDs have shown the widest range of evidence of lowered tissue (visceral fat and liver) and serum inflammation. In contrast, despite reducing postprandial hyperglycaemia, the effect of alpha-glucosidase inhibitors on inflammatory markers appears rather modest, whereas dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and glucagon-like peptide-1 (GLP-1) receptor agonists appear more promising in this respect. These incretin-based therapies exert pleiotropic effects, including reports of anti-inflammatory activity. No human data are available so far regarding sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Although they may have indirect effects due to reduced glucotoxicity, their specific mode of action in the kidneys does not suggest systemic anti-inflammatory activity. Also, in spite of the complex relationship between insulin and atherosclerosis, exogenous insulin may also exert anti-inflammatory effects. Nevertheless, for all these glucose-lowering agents, it is essential to distinguish between anti-inflammatory effects resulting from better glucose control and potential anti-inflammatory effects related to intrinsic actions of the pharmacological class. Finally, it would also be of major clinical interest to define what role the anti-inflammatory effects of these glucose-lowering agents may play in the prevention of macrovascular and microvascular diabetic complications. [less ▲]

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See detailLa correction de l’expression écrite en langue étrangère en Fédération Wallonie-Bruxelles : expliciter l’implicite
Noiroux, Kevin ULg; Simons, Germain ULg

in Les cahiers de l’Association des chercheurs et enseignants didacticiens des langues étrangères (acedle) (2015)

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See detailMethanotrophy within the water column of a large meromictic tropical lake (Lake Kivu, East Africa)
Morana, C.; Borges, Alberto ULg; Roland, Fleur ULg et al

in Biogeosciences (2015), 12(7), 2077-2088

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See detailCortical spreading depression decreases Fos expression in rat periaqueductal gray matter.
Borysovich Bogdanov, Volodymir; LOMBARD, Arnaud ULg; Multon, Sylvie ULg et al

in Neuroscience Letters (2015)

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See detailReporting nuclear cardiology: a joint position paper by the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI).
Tragardh, Elin; Hesse, Birger; Knuuti, Juhani et al

in European heart journal cardiovascular Imaging (2015)

The report of an imaging procedure is a critical component of an examination, being the final and often the only communication from the interpreting physician to the referring or treating physician. Very ... [more ▼]

The report of an imaging procedure is a critical component of an examination, being the final and often the only communication from the interpreting physician to the referring or treating physician. Very limited evidence and few recommendations or guidelines on reporting imaging studies are available; therefore, an European position statement on how to report nuclear cardiology might be useful. The current paper combines the limited existing evidence with expert consensus, previously published recommendations as well as current clinical practices. For all the applications discussed in this paper (myocardial perfusion, viability, innervation, and function as acquired by single photon emission computed tomography and positron emission tomography or hybrid imaging), headings cover laboratory and patient demographics, clinical indication, tracer administration and image acquisition, findings, and conclusion of the report. The statement also discusses recommended terminology in nuclear cardiology, image display, and preliminary reports. It is hoped that this statement may lead to more attention to create well-written and standardized nuclear cardiology reports and eventually lead to improved clinical outcome. [less ▲]

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See detailMicrofluidic Enzymatic Biosensing Systems: a Review
Mross, Stefan; Pierrat, Sebastien; Zimmermann, Tom et al

in Biosensors & Bioelectronics (2015), 70

Microfluidic biosensing systems with enzyme-based detection have been extensively studied in the last years owing to features such as high specificity, a broad range of analytes and a high degree of ... [more ▼]

Microfluidic biosensing systems with enzyme-based detection have been extensively studied in the last years owing to features such as high specificity, a broad range of analytes and a high degree of automation. This review gives an overview of the most important factors associated with these systems. In the first part, frequently used immobilization protocols such as physisorption and covalent bonding and detection techniques such as amperometry and fluorescence measurements are discussed with respect to effort, lifetime and measurement range. The Michaelis–Menten model describing the kinetics of enzymatic reactions, the role of redox mediators and the limitations of the linear measurement range of enzymatic sensors are introduced. Several possibilities of extending the linear measurement range in microfluidic systems such as diffusion-limiting membranes and the flow injection setup are presented. Regarding the integration of enzymes into microfluidic systems during the fabrication process, the constraints imposed by the biomolecules due to the limited usage of high temperatures and solvents are addressed. In the second part, the most common forms of enzyme integration into microfluidic systems, i.e. in channels and on electrodes, on microparticles, on paper and thread and as injected enzyme solutions, are reviewed, focusing on fabrication, applications and performance. [less ▲]

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See detailRoot System Markup Language: toward an unified root architecture description language
Lobet, Guillaume ULg; Pound, Michael; Diener, Julien et al

in Plant Physiology (2015)

The number of image analysis tools supporting the extraction of architectural features of root systems has increased over the last years. These tools offer a handy set of complementary facilities, yet it ... [more ▼]

The number of image analysis tools supporting the extraction of architectural features of root systems has increased over the last years. These tools offer a handy set of complementary facilities, yet it is widely accepted that none of these software tool is able to extract in an efficient way growing array of static and dynamic features for different types of images and species. . We describe the Root System Markup Language (RSML) that has been designed to overcome two major challenges: (i) to enable portability of root architecture data between different software tools in an easy and interoperable manner allowing seamless collaborative work, and (ii) to provide a standard format upon which to base central repositories which will soon arise following the expanding worldwide root phenotyping effort. RSML follows the XML standard to store 2D or 3D image metadata, plant and root properties and geometries, continuous functions along individual root paths and a suite of annotations at the image, plant or root scales, at one or several time points. Plant ontologies are used to describe botanical entities that are relevant at the scale of root system architecture. An xml-schema describes the features and constraints of RSML and open-source packages have been developed in several languages (R, Excel, Java, Python, C#) to enable researchers to integrate RSML files into popular research workflow. [less ▲]

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See detailGenetic analysis of heat stress effects on yield traits, udder health, and fatty acids of Walloon Holstein cows
Hammami, Hedi ULg; Vandenplas, Jérémie; Vanrobays, Marie-Laure ULg et al

in Journal of Dairy Science (2015), 98(7), 4956-4968

Genetic parameters that considered tolerance for heat stress were estimated for production, udder health, and milk composition traits. Data included 202,733 test-day records for milk, fat, and protein ... [more ▼]

Genetic parameters that considered tolerance for heat stress were estimated for production, udder health, and milk composition traits. Data included 202,733 test-day records for milk, fat, and protein yields, fat and protein percentages, somatic cell score (SCS), 10 individual milk fatty acids (FA) predicted by mid-infrared spectrometry, and 7 FA groups. Data were from 34,468 first-lactation Holstein cows in 862 herds in the Walloon region of Belgium and were collected between 2007 and 2010. Test-day records were merged with daily temperature-humidity index (THI) values based on meteorological records from public weather stations. The maximum distance between each farm and its corresponding weather station was 21km. Linear reaction norm models were used to estimate the intercept and slope responses of 23 traits to increasing THI values. Most yield and FA traits had phenotypic and genetic declines as THI increased, whereas SCS, C18:0, C18:1 cis-9, and 4 FA groups (unsaturated FA, monounsaturated FA, polyunsaturated FA, and long-chain FA) increased with THI. Moreover, the latter traits had the largest slope-to-intercept genetic variance ratios, which indicate that they are more affected by heat stress at high THI levels. Estimates of genetic correlations within trait between cold and hot environments were generally high (>0.80). However, lower estimates (< = 0.67) were found for SCS, fat yield, and C18:1 cis-9, indicating that animals with the highest genetic merit for those traits in cold environments do not necessarily have the highest genetic merit for the same traits in hot environments. Among all traits, C18:1 cis-9 was the most sensitive to heat stress. As this trait is known to reflect body reserve mobilization, using its variations under hot conditions could be a very affordable milk biomarker of heat stress for dairy cattle expressing the equilibrium between intake and mobilization under warm conditions. [less ▲]

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See detailComputational benchmarking for ultrafast electron dynamics: wavefunction methods vs density functional theory
Oliveira, Micael J. T.; Mignolet, Benoît ULg; Kus, Tomasz et al

in Journal of Chemical Theory and Computation (2015), 11

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See detailLa vignette therapeutique de l'etudiant. Instaurer, surveiller et interrompre des traitements medicamenteux: un exercice pratique en vie reelle.
Scheen, André ULg

in Revue medicale de Liege (2015), 70(1), 49-53

Some patients are exposed to complex clinical situations, which impose a careful analysis of both the indications and contraindications of ongoing pharmacological treatments as well as of the dosing or ... [more ▼]

Some patients are exposed to complex clinical situations, which impose a careful analysis of both the indications and contraindications of ongoing pharmacological treatments as well as of the dosing or drug adjustments to be proposed. This article illustrates some problems encountered when a new drug therapy is initiated, when medications with narrow therapeutic window should be supervised and when some drugs should be stopped mainly for safety reasons. The clinical case relates the story of a patient with type 2 diabetes, arterial hypertension and coronary heart disease, who presents a congestive heart failure associated with an episode of atrial fibrillation and a severe renal insufficiency. [less ▲]

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See detailEffects of isoflurane and sevoflurane on the neutrophil myeloperoxidase system of horses
MINGUET, Grégory ULg; Franck, Thierry ULg; JORIS, Jean ULg et al

in Veterinary Immunology and Immunopathology (2015)

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See detailPreparation and characterizations of EGDE crosslinked chitosan electrospun membranes
Aqil, Abdelhafid ULg; Tchemtchoua, Victor T.; Colige, Alain ULg et al

in Clinical Hemorheology and Microcirculation (2015), 60(1), 39-50

Composite Crosslinked nanofibrous membranes of chitosan, ethylene glycol diglycidyl ether (EGDE) and polyethy- 10 lene oxide was successfully prepared with bead free morphology via electrospinning ... [more ▼]

Composite Crosslinked nanofibrous membranes of chitosan, ethylene glycol diglycidyl ether (EGDE) and polyethy- 10 lene oxide was successfully prepared with bead free morphology via electrospinning technique followed by heat mediated 11 chemical crosslinking. Architectural stability of nanofiber mat in aqueous medium was achieved by chemical crosslinking of 12 only 1% EGDE, and tensile strength tests revealed that increasing EGDE content has considerably enhance the elastic modu- 13 lus of nanofibers. The structure, morphology and mechanical properties of nanofibers were characterized by Attenuated Total 14 Reflection-Fourier Transform Infrared spectroscopy (ATR–FTIR), scanning electron microscopy (SEM) and Instron machine, 15 respectively. Skin fibroblasts and endothelial cells showedgood attachment, proliferation and viability on crosslinked electrospun 16 membranes. The results indicate a good biocompatibility and non-toxic nature of the resulted membrane. [less ▲]

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See detailE-learning in cardiovascular imaging: another step towards a structured educational approach.
Cosyns, Bernard; De Diego, Jose Juan Gomez; Stefanidis, Alexandros et al

in European heart journal cardiovascular Imaging (2015)

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See detailOptimization of a cheap and residential small-scale production of edible crickets with local by-products as an alternative protein-rich human food source in Ratanakiri Province (Cambodia)
Caparros Megido, Rudy ULg; Alabi, Taofic ULg; Nieus, Clément et al

in Journal of the Science of Food and Agriculture (2015)

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may ... [more ▼]

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may represent a sustainable, cost effective and high quality alternative source of protein to traditional livestock. This study aimed to optimise a cheap and residential cricket breeding system based on unused wild resources. The cricket development, Teleogryllus testaceus (Walker), under seven diets composed of taro aerial parts, young cassava leaves, young cashew leaves and brown rice flour (with or without banana slices), versus a traditionally used broiler feed diet was studied. Results - Cricket mortality was low in all diets, except the two cashew-based diets. Total biomass was significantly higher under the broiler feed, in addition to the two diets containing a combination of cassava leaf powder and brown rice. Yet, crickets fed with the taro diet had the highest percentage of protein. Concerning the breeding system cost, units using cassava leaves were the cheapest ones. Conclusion – Diets based of cassava leaves seems to be the most promising ones. Nevertheless, to produce crickets with a high body mass and a high protein level, a new experiment must be realised in which the cassava leaf maturity will be adapted to fit with the cricket growth stage. Moreover, to reduce the cost of the breeding units, handmade local products should be used instead of purchased components. [less ▲]

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See detailLa médecine personnalisée : aspects pharmacoéconomiques
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg; Ethgen, Olivier ULg

in Revue Médicale de Liège (2015), 70(5-6), 339-342

Personalized medicine : pharmacoeconomic aspects Summary : The development and establishment of personalized medicine should allow the improvement of the quality of the care services as well as of the ... [more ▼]

Personalized medicine : pharmacoeconomic aspects Summary : The development and establishment of personalized medicine should allow the improvement of the quality of the care services as well as of the development of new and adapted therapeutic solutions. In a society, whose resources for health care are not endless, the issue of costs and economic effectiveness of personalized medicine is important. Numerous pharmacoeconomic studies have been conducted and many of them suggest that personalized medicine leads to better health, but at higher cost. However, the pharmacoeconomic methods developed over recent years will have to be adapted to better take into account the complexity of the problem, especially the capacity and the reliability of tests to best target patients, and also the whole care process of patients. [less ▲]

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See detailCardiac computed tomography core syllabus of the European Association of Cardiovascular Imaging (EACVI).
Nieman, Koen; Achenbach, Stephan; Pugliese, Francesca et al

in European heart journal cardiovascular Imaging (2015)

The European Association of Cardiovascular Imaging (EACVI) Core Syllabus for Cardiac Computed Tomography (CT) is now available online. The syllabus lists key elements of knowledge in Cardiac CT. It ... [more ▼]

The European Association of Cardiovascular Imaging (EACVI) Core Syllabus for Cardiac Computed Tomography (CT) is now available online. The syllabus lists key elements of knowledge in Cardiac CT. It represents a framework for the development of training curricula and provides expected knowledge-based learning outcomes to the Cardiac CT trainees. [less ▲]

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See detailConservation research presence protects: a case study of great ape abundance in the Dja region, Cameroon
Tagg, Nikki; Willie, Jacob; Duarte, Jesus et al

in Animal Conservation (2015)

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See detailBilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway
Alhosin, Mahmoud; León-González1, Antonio J.; Dandache et al

in Scientific Reports (2015), 5

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an ... [more ▼]

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an anthocyanin-rich dietary bilberry extract (Antho 50) on B CLL cells from 30 patients and on peripheral blood mononuclear cells (PBMCs) from healthy subjects, and determined the underlying mechanism. Antho 50 induced concentration- and time-dependent pro-apoptotic effects in B CLL cells isolated from patients but little or no effect in PBMCs. Among the main phenolic compounds present in this bilberry extract, delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside showed the highest apoptotic effect on B CLL cells, suggesting that anthocyanins play a main role in the cytotoxic activity. Antho 50-induced apoptosis is associated with activation of caspase 3 and down-regulation of the anti-apoptotic protein UHRF1. Antho 50 induced also rapid dephosphorylation of Akt and Bad, and down-regulation of Bcl-2 resulting in reduced cell viability. Antho 50 significantly induced PEG-catalase-sensitive formation of reactive oxygen species in B CLL cells. PEG-catalase prevented the Antho 50-induced reduced cell viability, induction of apoptosis, up-regulation of caspase 3, down-regulation of UHRF1 and Bcl-2, and dephosphorylation of Bad. The present findings indicate that Antho 50 exhibits strong pro-apoptotic activity through redox-sensitive caspase 3 activation-related mechanism in B CLL cells involving dysregulation of Bad/Bcl-2 pathway. This activity is due, at least in part, to a composition rich on glucoside and rutinoside derivatives of delphinidin. They further suggest that Antho 50 has chemotherapeutic potential by targeting selectively B CLL cells. [less ▲]

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See detailChemotherapy-driven dysbiosis in the intestinal microbiome
Montassier, E.; Gastinne, T.; Vangay, P. et al

in Alimentary Pharmacology & Therapeutics (2015)

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See detailCompte rendu de Alan C. BOWEN, "Simplicius on the Planets and their Motions. In Defense of a Heresy"
Gavray, Marc-Antoine ULg

in Revue Philosophique de Louvain (2015), 113(1), 188-190

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See detailVISMODEGIB ET CARCINOMES BASOCELLULAIRES LOCALEMENT AVANCES
LEBAS, Eglantine ULg; RORIVE, Andrée ULg; EL HAYDERI, Lara ULg et al

in Revue Médicale de Liège (2015)

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in ... [more ▼]

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in the pathogenesis of basal cell carcinoma. Vismodegib is a selective inhibitor of this pathway and may be administered orally. Its main indication is locally advanced basal cell carcinoma, when other therapeutic options have failed or are contra-indicated. Vismodegib can also be used as prophylactic therapy in the Gorlin syndrome or basal cell nevomatosis. Its principal adverse effects are muscle spasms, alopecia and altered taste. They are frequent, but often moderate in intensity; they sometimes restrict continuation of treatment. Two clinical cases are presented, relating the efficacity and tolerance of this new therapeutic option. [less ▲]

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See detailApplication of random eigenvalue analysis to assess bridge flutter probability
Canor, Thomas; Caracoglia, Luca; Denoël, Vincent ULg

in Journal of Wind Engineering and Industrial Aerodynamics (2015), 140(0), 79--86

Abstract This study examines the well-known issue of evaluating the flutter probability for a long-span bridge, necessary for assessing structural integrity and reliability. The motivation stems from the ... [more ▼]

Abstract This study examines the well-known issue of evaluating the flutter probability for a long-span bridge, necessary for assessing structural integrity and reliability. The motivation stems from the need for critically reviewing and investigating a number of existing numerical approaches (e.g., random perturbation analysis, collocation methods, Galerkin approach) for the modeling and the solution of stochastic dynamic problems, by adapting them to the specific problem. The study proposes a generalized formulation for stochastic bridge flutter in terms of random eigenvalue analysis. A 1200 m suspension bridge model is used in the numerical simulations to compare the various methods and to provide indications on advantages and limitations of each method. Moreover, the link between the proposed formulation and existing studies on the propagation of uncertainty in aeroelastic systems, for example associated with measurement errors in wind tunnel, is examined. [less ▲]

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See detailThe influence of various reef sounds on coral-fish larvae behaviour
Parmentier, Eric ULg; Berten, Laetitia; Rigo, Pierre ULg et al

in Journal of Fish Biology (2015)

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See detailX-linked acrogigantism (X-LAG) syndrome : Clinical Profile and Therapeutic responses
Beckers, Albert ULg; Lodish, MB; Trivellin, G et al

in Endocrine-Related Cancer (2015), 22

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See detailFunctional analysis of the three HMA4 copies of the metal hyperaccumulator Arabidopsis halleri
Nouet, Cécile ULg; Charlier, Jean-Benoit; Carnol, Monique ULg et al

in Journal of Experimental Botany (2015), in press

In Arabidopsis halleri, the AhHMA4 gene has an essential function in Zn/Cd hypertolerance and hyperaccumulation by mediating root to shoot translocation of metals. Constitutive high expression of AhHMA4 ... [more ▼]

In Arabidopsis halleri, the AhHMA4 gene has an essential function in Zn/Cd hypertolerance and hyperaccumulation by mediating root to shoot translocation of metals. Constitutive high expression of AhHMA4 results from a tandem triplication and cis-activation of the promoter of all three copies. The three AhHMA4 copies possess divergent promoter sequences, but highly conserved coding sequences, and display identical expression profiles in the root and shoot vascular system. Here, we expressed an AhHMA4::GFP fusion under the control of each three A. halleri HMA4 promoters in a hma2hma4 double mutant of Arabidopsis thaliana to individually examine the function of each A. halleri AhHMA4 copy. The protein localized non-polarly at the plasma membrane of the root pericycle cells of both A. thaliana and A. halleri. The expression of each AhHMA4::GFP copy complemented the severe Zn deficiency phenotype of the hma2hma4 mutant by restoring root-to-shoot translocation of zinc. However, each copy had different impact on metal homeostasis in the A. thaliana genetic background: AhHMA4 copies 2 and 3 were more highly expressed and provided higher Zn tolerance in roots and accumulation in shoots than copy 1, whereas AhHMA4 copy 3 also increased Cd tolerance in roots. Our data suggest a certain extent of functional differentiation among the three A. halleri HMA4 copies, stemming from differences in expression levels rather than in expression profile. HMA4 is a key node of the Zn homeostasis network and small changes in expression level can have major impact on Zn allocation to root or shoot tissues. [less ▲]

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See detailOutils didactiques et (in)égalités. Texte de cadrage et présentation succincte des contributions.
Simons, Germain ULg

in Didactiques en pratique (2015), (1), 4-7

Ce texte présente la thématique abordée lors de l'Université d'été du Cifen 2014 : "Outils didactiques et (in)égalités". Il propose également un bref résumé de chacune des contributions proposées lors des ... [more ▼]

Ce texte présente la thématique abordée lors de l'Université d'été du Cifen 2014 : "Outils didactiques et (in)égalités". Il propose également un bref résumé de chacune des contributions proposées lors des conférences de la matinée ou lors des ateliers de l'après-midi. [less ▲]

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See detailThe finite index basis property
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Journal of Pure and Applied Algebra (2015), 219(7), 25212537

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See detailOptimal control of a Cope rearrangement by coupling the reaction path to a dissipative bath or a second active mode
Chenel, Aurélie; Meier, Christoph; Dive, Georges et al

in The Journal of Chimical Physics (2015), 142

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See detailCatalogue of the types and illustrated specimens recovered from the ‘black marble’ of Denée, a marine conservation-Lagerstätte from the Mississippian of southern Belgium
Mottequin, Bernard ULg; Poty, Edouard; Prestianni, Cyrille

in Geologica Belgica (2015)

The Viséan ‘black marble’ of Denée is one of the best preserved Mississippian fossil assemblages. This Lagerstätte is famous for the exceptional preservation of several groups of macro-organisms (fishes ... [more ▼]

The Viséan ‘black marble’ of Denée is one of the best preserved Mississippian fossil assemblages. This Lagerstätte is famous for the exceptional preservation of several groups of macro-organisms (fishes, echinoids, graptolites). However, only a part of the fauna has received attention from specialists and most of the phyla may benefit from a modern revision based on new investigative techniques such as 3D imagery and CT-scanning. Almost all the specimens illustrated in the literature have been traced and we present here a comprehensive catalogue of this material. Representatives of several minor groups are photographically illustrated for the first time as well as five emblematic specimens of the styracopterid genus Benedenius (Pisces). For purposes of nomenclatural formality, the lectotypes of Benedenius deneensis Traquair (in de Koninck, 1878), B. soreili Fraipont, 1890, Oligoporus soreili Fraipont, 1904, Taeniaster? fournieri Fraipont, 1904, and Scaphiocrinus longicaudatus Fraipont, 1904 are here selected. [less ▲]

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See detailPredicting biomass and grain protein content using Bayesian methods
Mansouri, Majdi ULg; Destain, Marie-France ULg

in Stochastic Environmental Research & Risk Assessment (2015)

This paper deals with the problem of predicting biomass and grain protein content using improved particle filtering (IPF) based on minimizing the Kullback–Leibler divergence. The performances of IPF are ... [more ▼]

This paper deals with the problem of predicting biomass and grain protein content using improved particle filtering (IPF) based on minimizing the Kullback–Leibler divergence. The performances of IPF are compared with those of the conventional particle filtering (PF) in two comparative studies. In the first one, we apply IPF and PF at a simple dynamic crop model with the aim to predict a single state variable, namely the winter wheat biomass, and to estimate several model parameters. In the second study, the proposed IPF and the PF are applied to a complex crop model (AZODYN) to predict a winter-wheat quality criterion, namely the grain protein content. The results of both comparative studies reveal that the IPF method provides a better estimation accuracy than the PF method. The benefit of the IPF method lies in its ability to provide accuracy related advantages over the PF method since, unlike the PF which depends on the choice of the sampling distribution used to estimate the posterior distribution, the IPF yields an optimum choice of this sampling distribution, which also utilizes the observed data. The performance of the proposed method is evaluated in terms of estimation accuracy, root mean square error, mean absolute error and execution times. [less ▲]

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See detailSolutrean and Magdalenian ferruginous rocks heat-treatment: accidental and/or deliberate action?
Salomon, Hélène ULg; Vignaud, Colette; Lahlil, Sophia et al

in Journal of Archaeological Science (2015), 55

Heating of prehistoric coloring materials can induce radical changes in color indicative of structural matter transformation. For instance, the structure of the yellow iron oxide-rich mineral, goethite ... [more ▼]

Heating of prehistoric coloring materials can induce radical changes in color indicative of structural matter transformation. For instance, the structure of the yellow iron oxide-rich mineral, goethite, changes into the red iron oxide-rich mineral, hematite, when it is heated to around 250-300°C. For a long time, heating has been thought to be the reason for the high frequencies of red rocks used in camp sites and the red pigments in rock art paintings. However, records of heat-treatment of coloring materials are usually not well documented; the contextual information is not clear enough to confirm intentional heating. Two Solutrean camp sites (the flint workshop Les Maîtreaux and the hunting site Combe Saunière I) and one middle Magdalenian cave with rock art (Grotte Blanchard, La Garenne) allow us to study the heating process of ferruginous rocks. All three sites, which have been excavated relatively recently, have well-defined archaeological records and strong associations between the ferruginous rocks and other artifacts. With the use of X-ray diffraction and electron µ-diffraction for identifying structural modification and SEM-FEG and TEM-FEG for detecting dehydration nano-pores, we have strong evidence for intentional heat-treatment of yellow goethite-rich materials in two archaeological contexts and one site for unintentional heating, where rocks were only partially transformed. Intentional heating to obtain red hematite from primary goethite would have required ingenious methods of temperature control in fireplace settings and purpose-built ground ovens. [less ▲]

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See detailDramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal
Ayora, A F; HERION, Francine ULg; ROMPEN, Eric ULg et al

in Journal of Clinical Periodontology (2015), 42

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these ... [more ▼]

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients. [less ▲]

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See detailUne épée pour saint Pierre ? Les princes Valois d'Anjou et le Grand Schisme d’Occident
Masson, Christophe ULg

in Moyen Age (Le) (2015), CXX(I), 71-81

At the time of the Great Western Schism, the dukes of Valois d’Anjou tried several times to establish themselves in the Kingdom of Naples, vassal to the Holy See. With the support of the Avignon popes ... [more ▼]

At the time of the Great Western Schism, the dukes of Valois d’Anjou tried several times to establish themselves in the Kingdom of Naples, vassal to the Holy See. With the support of the Avignon popes, they received regular financial aid in addition to the concession of the royal title. If this recognition allowed them to legitimize their war of conquest and thereby reconcile the backing of many Neapolitan feudal lords, it came with the duty of throwing the pope in Rome under the throne of Saint Peter. However, in spite of promises made in this guise, the Dukes of Anjou showed little inclination to direct its army toward Lazio. In sum, if the justification at the basis of all of the Angevine military campaigns was indispensable for their existence, it was of little factual consequence. [less ▲]

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See detailCan we identify patients with high risk of osteoarthritis progression who will respond to treatment ? A focus on epidemiology and phenotype of osteoarthritis
Bruyère, Olivier ULg; Cooper, C; Arden, N et al

in Drugs & Aging (2015), 32(3), 179-187

Osteoarthritis is a syndrome affecting a variety of patient profiles. A European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and the European Union Geriatric Medicine ... [more ▼]

Osteoarthritis is a syndrome affecting a variety of patient profiles. A European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and the European Union Geriatric Medicine Society working meeting explored the possibility of identifying different patient profiles in osteoarthritis. The risk factors for the development of osteoarthritis include systemic factors (e.g., age, sex, obesity, genetics, race, and bone density) and local biomechanical factors (e.g., obesity, sport, joint injury, and muscle weakness); most also predict disease progression, particularly joint injury, malalignment, and synovitis/effusion. The characterization of patient profiles should help to better orientate research, facilitate trial design, and define which patients are the most likely to benefit from treatment. There are a number of profile candidates. Generalized, polyarticular osteoarthritis and local, monoarticular osteoarthritis appear to be two different profiles; the former is a feature of osteoarthritis comorbid with inflammation or the metabolic syndrome, while the latter is more typical of post-trauma osteoarthritis, especially in cases with severe malalignment. Other biomechanical factors may also define profiles, such as joint malalignment, loss of meniscal function, and ligament injury. Early- and late-stage osteoarthritis appear as separate profiles, notably in terms of treatment response. Finally, there is evidence that there are two separate profiles related to lesions in the subchondral bone, which may determine benefit from bone-active treatments. Decisions on appropriate therapy should be made considering clinical presentation, underlying pathophysiology, and stage of disease. Identification of patient profiles may lead to more personalized healthcare, with more targeted treatment for osteoarthritis. [less ▲]

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See detailThe impact of oregano (Origanum heracleoticum) essential oil and carvacrol on virulence gene transcription by Escherichia coli O157:H7
Mith, Hasika; Clinquart, Antoine ULg; Zhiri, Abdesselam et al

in FEMS Microbiology Letters (2015), 362

The aim of the current study was to determine, via reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis, the effect of oregano essential oil (Origanum heracleoticum) and ... [more ▼]

The aim of the current study was to determine, via reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis, the effect of oregano essential oil (Origanum heracleoticum) and carvacrol, its major component, on the expression of virulence-associated genes in enterohaemorrhagic Escherichia coli (EHEC) O157:H7 ATCC strain 35150. Both oregano oil and carvacrol demonstrated their efficacy firstly, by inhibiting the transcription of the ler gene involved in up regulation of the LEE2, LEE3 and LEE4 promoters and of attaching and effacing lesions and secondly by decreasing both Shiga toxin and fliC genes expression. In addition, a decrease in luxS gene transcription involved in quorum sensing was observed. These results were dose dependent and showed a specific effect of O. heracleoticum and carvacrol in downregulating the expression of virulence genes in EHEC O157:H7. These findings suggest that oregano oil and carvacrol have the potential to mitigate the adverse health effects caused by virulence gene expression in EHEC O157: [less ▲]

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See detailMagnetic shielding performances of YBa2Cu3O7−δ -coated silver tubes obtained by electrophoretic deposition
Devendra Kumar, N; Closset, Raphaël ULg; Wera, Laurent ULg et al

in Superconductor Science and Technology (2015), 28

We report a complete procedure to achieve multilayer YBCO thick films by electrophoretic deposition on silver tubes using a suspension of YBCO powder in butanol. With the aim to optimize the magnetic ... [more ▼]

We report a complete procedure to achieve multilayer YBCO thick films by electrophoretic deposition on silver tubes using a suspension of YBCO powder in butanol. With the aim to optimize the magnetic shielding performances of the coatings, we have carried out an extensive investigation of the influence of the deposition parameters, the multilayer deposition sequence and the intermediate/final heat treatments on the coating microstructure. Using the optimized conditions, a 24-layer YBCO coating has been successfully prepared on an 80 mm long Ag tube: the melt growth processed multilayered YBCO thick film thus obtained can shield an applied magnetic field of 1.9 mT at 77 K, the highest value per thickness unit reported so far in the literature for these materials. [less ▲]

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See detailGalectin expression in cancer diagnosis and prognosis: a systematic review
Thijssen, Victor; Heusschen, Roy ULg; CAERS, Jo ULg et al

in Biochimica et Biophysica Acta - Reviews on Cancer (2015)

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See detailMale song quality modulates c-Fos expression in the auditory forebrain of the female canary.
Monbureau, Marie; Barker, Jennifer M.; Leboucher, Gerard et al

in Physiology & behavior (2015), 147

In canaries, specific phrases of male song (sexy songs, SS) that are difficult to produce are especially attractive for females. Females exposed to SS produce more copulation displays and deposit more ... [more ▼]

In canaries, specific phrases of male song (sexy songs, SS) that are difficult to produce are especially attractive for females. Females exposed to SS produce more copulation displays and deposit more testosterone into their eggs than females exposed to non-sexy songs (NS). Increased expression of the immediate early genes c-Fos or zenk (a.k.a. egr-1) has been observed in the auditory forebrain of female songbirds hearing attractive songs. C-Fos immunoreactive (Fos-ir) cell numbers were quantified here in the brain of female canaries that had been collected 30min after they had been exposed for 60min to the playback of SS or NS or control white noise. Fos-ir cell numbers increased in the caudomedial mesopallium (CMM) and caudomedial nidopallium (NCM) of SS birds as compared to controls. Song playback (pooled SS and NS) also tended to increase average Fos-ir cell numbers in the mediobasal hypothalamus (MBH) but this effect did not reach full statistical significance. At the individual level, Fos expression in CMM was correlated with its expression in NCM and in MBH but also with the frequency of calls that females produced in response to the playbacks. These data thus indicate that male songs of different qualities induce a differential metabolic activation of NCM and CMM. The correlation between activation of auditory regions and of the MBH might reflect the link between auditory stimulation and changes in behavior and reproductive physiology. [less ▲]

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See detailAcyclic, connected and tree sets
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Monatshefte für Mathematik (2015), 176(4), 521550

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See detailCrystallisation-driven self-assembly of poly(2-isopropyl-2- oxazoline)-block-poly(2-methyl-2-oxazoline) above the LCST
Legros, Camille ULg; De Pauw-Gillet, Marie-Claire ULg; Tam, Kam Chiu et al

in Soft Matter (2015)

The solution behaviour in water of a polyoxazoline-type block copolymer, namely poly(2- isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline), denoted as P(iPrOx-b-MeOx), above the lower critical ... [more ▼]

The solution behaviour in water of a polyoxazoline-type block copolymer, namely poly(2- isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline), denoted as P(iPrOx-b-MeOx), above the lower critical solution temperature (LCST) of the PiPrOx block was exploited to induce a temporary or permanent self-assembly. Spherical micelles were first obtained and could be disassembled in a reversible manner when kept for a short period of time (i.e. t < 1h30) above the LCST, and cooled down to room temperature. In contrast, annealing the copolymer solution for more than 1h30 at 65 °C induced the crystallisation of the PiPrOx block, as evidenced by wide angle X-ray scattering (WAXS) experiments. This crystallisationdriven self-assembly phenomenon resulted in different morphologies, including spherical and distorted crystallised micelles and micron-size fibers, their relative proportion varying with annealing time. Formation of micron-size range fiber-like structures might be explained by a re-organization of parent crystallised micelles. The crystal structure, as determined by WAXS, appeared to be identical to that of the PiPrOx homopolymer. [less ▲]

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See detailSpeed limit to the Abrikosov lattice in mesoscopic superconductors
Grimaldi, Gaia; Leo, Antonio; Sabatino, P. et al

in Physical Review. B : Condensed Matter (2015)

We study the instability of the superconducting state in a mesoscopic geometry for the low pinning material Mo3Ge characterized by a large Ginzburg-Landau parameter. We observe that in the current driven ... [more ▼]

We study the instability of the superconducting state in a mesoscopic geometry for the low pinning material Mo3Ge characterized by a large Ginzburg-Landau parameter. We observe that in the current driven switching to the normal state from a nonlinear region of the Abrikosov flux flow, the mean critical vortex velocity reaches a limiting maximum velocity as a function of the applied magnetic fi eld. Based on time dependent Ginzburg-Landau simulations we argue that the observed behavior is owed to the high velocity vortex dynamics confi ned on a mesoscopic scale. We build up a general phase diagram which includes all possible dynamic confi gurations of Abrikosov lattice in a mesoscopic superconductor. [less ▲]

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See detailSafety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes.
Scheen, André ULg

in Expert opinion on drug safety (2015), epub

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy a growing place in the armamentarium of drugs used for the management of hyperglycemia in type 2 diabetes, although some safety ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy a growing place in the armamentarium of drugs used for the management of hyperglycemia in type 2 diabetes, although some safety concerns have been raised in recent years. Areas covered: An updated review providing an analysis of available safety data (meta-analyses, randomized controlled trials, observational cohort and case-control studies and pharmacovigilance reports) with five commercialized DPP-4 inhibitors (sitagliptin, vildagliptin, saxagliptin, alogliptin, linagliptin). A special focus is given to overall safety profile; pancreatic adverse events (AEs) (acute pancreatitis, pancreatic cancer); overall cardiovascular safety (myocardial infarction and stroke); congestive heart failure concern and finally, safety in special populations (elderly, renal impairment). Expert opinion: The good tolerance/safety profile of DPP-4 inhibitors has been largely confirmed, including in more fragile populations (elderly, renal impairment) with almost no increased risk of infection or gastrointestinal AEs, no weight gain and a minimal risk of hypoglycemia. Although an increased risk of acute pancreatitis and pancreatic cancer was suspected, the complete set of available data appears reassuring so far. Cardiovascular safety of DPP-4 inhibitors has been proven but an unexpected increased risk of heart failure has been reported which should be confirmed in ongoing trials and better understood. Further postmarketing surveillance is recommended. [less ▲]

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See detailL'image et le temps. Une poétique du récit historien chez Alphonse Dupront.
Servais, Amandine ULg

in Phantasia (2015), 1

Par l’étude d’un cas – Alphonse Dupront (particulièrement son texte « Itinéraire », in Du sacré. Croisades et pèlerinages. Images et langages) – j’entends éprouver l’hypothèse selon laquelle l’image ... [more ▼]

Par l’étude d’un cas – Alphonse Dupront (particulièrement son texte « Itinéraire », in Du sacré. Croisades et pèlerinages. Images et langages) – j’entends éprouver l’hypothèse selon laquelle l’image détermine des modalités inédites du savoir historien. Dupront ne produit pas, sur les images, un discours en surplomb ni un texte où l’image est prétextuelle. Il réalise une expérience : son texte est à la fois le lieu d’une pratique et l’endroit où se réfléchit cette pratique. Le récit de Dupront constitue un métadiscours et c’est par l’image que le récit historien est contraint de s’engager dans l’autoréflexivité. Chez Dupront, les catégories du temps et de l’image sont étroitement intriquées. Cette intrication des catégories vient de ce que la définition du temps (longue durée) engendre une conception de l’événement (le vécu qu’étudie l’historien) s’accordant à une certaine définition de l’image (l’image entendue comme agrégat d’hétérogènes et, par-là, possédant un potentiel d’actualisation). Dès lors, événement et image partagent une même propriété, celle d’être actualisables. Cette contiguïté catégorielle fonde le système dupronien. En cela, l’image occupe une place prépondérante ; elle détermine des modalités inédites du savoir historique et questionne le dispositif historique dans son ensemble. Ainsi, la marge où se tient Dupront révèle quelque chose de fort qui œuvre au sein de la pratique. [less ▲]

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See detailInfluence of viscosity on Liquid Flow Inside Structured Packings
Bradttmöller, Christian; Janzen, Anna; Crine, Michel ULg et al

in Industrial & Engineering Chemistry Research (2015), 54

In this study, X-ray computer tomography and light-induced fluorescence were applied to investigate the morphology of liquid flow inside structured packings. Fluid dynamic parameters such as liquid holdup ... [more ▼]

In this study, X-ray computer tomography and light-induced fluorescence were applied to investigate the morphology of liquid flow inside structured packings. Fluid dynamic parameters such as liquid holdup and wetted surface were determined to study the effect of the variation of viscosity and liquid load. Flow patterns inside the packing were identified and categorized. Liquid film thickness and its distribution were analyzed on single sheets. For both methods, the measured holdup values are in good agreement, despite differences in the techniques of measurement. For the flow patterns and their relative contribution, as well as mean liquid film thickness, a strong dependency on the varied parameters was found. Furthermore, the density function of film thickness distribution changed characteristically with liquid load and viscosity. The complementary use of tomography and optical assessment allowed an improved insight into flow phenomena and the observed interdependency of physical, geometric, and operational parameters. [less ▲]

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See detailImplausibility of the vibrational theory of olfaction.
Block, Eric; Jang, Seogjoo; Matsunami, Hiroaki et al

in Proceedings of the National Academy of Sciences of the United States of America (2015)

The vibrational theory of olfaction assumes that electron transfer occurs across odorants at the active sites of odorant receptors (ORs), serving as a sensitive measure of odorant vibrational frequencies ... [more ▼]

The vibrational theory of olfaction assumes that electron transfer occurs across odorants at the active sites of odorant receptors (ORs), serving as a sensitive measure of odorant vibrational frequencies, ultimately leading to olfactory perception. A previous study reported that human subjects differentiated hydrogen/deuterium isotopomers (isomers with isotopic atoms) of the musk compound cyclopentadecanone as evidence supporting the theory. Here, we find no evidence for such differentiation at the molecular level. In fact, we find that the human musk-recognizing receptor, OR5AN1, identified using a heterologous OR expression system and robustly responding to cyclopentadecanone and muscone, fails to distinguish isotopomers of these compounds in vitro. Furthermore, the mouse (methylthio)methanethiol-recognizing receptor, MOR244-3, as well as other selected human and mouse ORs, responded similarly to normal, deuterated, and 13C isotopomers of their respective ligands, paralleling our results with the musk receptor OR5AN1. These findings suggest that the proposed vibration theory does not apply to the human musk receptor OR5AN1, mouse thiol receptor MOR244-3, or other ORs examined. Also, contrary to the vibration theory predictions, muscone-d30 lacks the 1,380- to 1,550-cm-1 IR bands claimed to be essential for musk odor. Furthermore, our theoretical analysis shows that the proposed electron transfer mechanism of the vibrational frequencies of odorants could be easily suppressed by quantum effects of nonodorant molecular vibrational modes. These and other concerns about electron transfer at ORs, together with our extensive experimental data, argue against the plausibility of the vibration theory. [less ▲]

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See detailAcoustic monitoring of O2 production of a seagrass meadow
Felisberto, Paulo; Jesus, Sérgio M.; Zabel, Friedrich et al

in Journal of Experimental Marine Biology and Ecology (2015), 464(0), 75-87

Acoustic data were acquired in October 2011 over a Posidonia oceanica meadow in the Bay of la Revellata, Calvi, Corsica. The purpose was to develop an acoustic system for monitoring the oxygen (O2 ... [more ▼]

Acoustic data were acquired in October 2011 over a Posidonia oceanica meadow in the Bay of la Revellata, Calvi, Corsica. The purpose was to develop an acoustic system for monitoring the oxygen (O2) production of an entire seagrass meadow. In a shallow water area (b38 m), densely covered by P. oceanica, a sound source transmitted signals in 3 different bands (400–800 Hz, 1.5–3.5 kHz and 6.5–8.5 kHz) toward three self-recording hydrophones at a distance of 100 m, over the period of oneweek. The data showa high correlation between the diel cycle of the acoustic signals' energy received by the hydrophones and the temporal changes in water column O2 concentration as measured by optodes. The results thus show that a simple acoustic acquisition system can be used to monitor the O2-based productivity of a seagrass meadow at the ecosystem level with high temporal resolution. The finding of a significant production of O2 as bubbles in seagrass ecosystems suggests that net primary production is underestimated by methods that rely on the mass balance of dissolved O2 measurements. [less ▲]

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See detailWhich psychological factors influence Internet addiction? Evidence through an integrative model
Burnay, Jonathan ULg; Billieux, Joël; Blairy, Sylvie ULg et al

in Computers in Human Behavior (2015), 43

Since the appearance of Internet, several preoccupations have appeared as a result, with Internet addiction being one of the most common. The goals of the present study were two-fold. First, to examine ... [more ▼]

Since the appearance of Internet, several preoccupations have appeared as a result, with Internet addiction being one of the most common. The goals of the present study were two-fold. First, to examine which psychological factors are relevant to explain Internet addiction, including impulsivity, passion and social provision. Second, to incorporate all these factors into an integrative model. Based on multiple regressions and path analysis, results revealed a positive relation between Internet addiction and specific impulsivity components (lack of perseverance, urgency) and obsessive passion. Moreover, positive relations were observed between obsessive passion and reassurance of worth, opportunity for nurturance, sensation seeking and harmonious passion. In other words, Internet addiction is related to obsessive passion, but is explained by different psychological factors. Accordingly, both Internet addiction and obsessive passion can be viewed as two important and complementary facets of problematic Internet use. [less ▲]

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See detailVoedselveiligheid van insecten : een stand van zaken
Claeys, Wendie; Van Huffel, Xavier; Sindic, Marianne ULg

in Food Science and Law (2015), 2

Insects appear to be an interesting alternative source for food proteins. pending a clear European legislation, 10 insect species are currently tolerated on the Belgian market by the Belgian Food Safety ... [more ▼]

Insects appear to be an interesting alternative source for food proteins. pending a clear European legislation, 10 insect species are currently tolerated on the Belgian market by the Belgian Food Safety Agency. Edible insects are quite nutritious, but like vertebrates, they may contain pathogenes and toxic substances which can be hazardous to our health when consumed. The potential risks may, however, be largely controlled by the correct application of good hygiene and manufacturing practices during the breeding and marketing of these insects. Additionally, it is important to respect the appropriate storage and preparation conditions to heat the insects before consumption. Moreover, a possible allergic reaction of persons who are allergic to shellfishand/or dust mites cannot be excluded. [less ▲]

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See detailOn the increasing relevance of time in later Late Egyptian: jw sDm=f and jw jw=f r sDm, and other things
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (2015), 22

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See detailPositive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.
Bury, Daniel; Dahmane, Ismahene ULg; Derouaux, Adeline ULg et al

in Biochemical pharmacology (2015), 93(2), 141-50

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan ... [more ▼]

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan macromolecule. The essential function of the GT makes it an attractive antimicrobial target; therefore a better understanding of its function and its mechanism of interaction with substrates could help in the design and the development of new antibiotics. In this work, we have used a surface plasmon resonance Biacore((R)) biosensor, based on an amine derivative of moenomycin A immobilized on a sensor chip surface, to investigate the mechanism of binding of substrate analogous inhibitors to the GT. Addition of increasing concentrations of moenomycin A to the Staphylococcus aureus MtgA led to reduced binding of the protein to the sensor chip as expected. Remarkably, in the presence of low concentrations of the most active disaccharide inhibitors, binding of MtgA to immobilized moenomycin A was found to increase; in contrast competition with moenomycin A occurred only at high concentrations. This finding suggests that at low concentrations, the lipid II analogs bind to the acceptor site and induce a cooperative binding of moenomycin A to the donor site. Our results constitute the first indication of the existence of a positive cooperativity between the acceptor and the donor sites of peptidoglycan GTs. In addition, our study indicates that a modification of two residues (L119N and F120S) within the hydrophobic region of MtgA can yield monodisperse forms of the protein with apparently no change in its secondary structure content, but this is at the expense of the enzyme function. [less ▲]

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See detailAtmospheric Pressure Plasma as an Activation Step for Improving Protein Adsorption on Hydroxyapatite Powder
Ozhukil Kollath, Vinayaraj ULg; Put, Sofie; Mullens, Steven et al

in Plasma Processes and Polymers (2015)

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See detailFocal cerebral ischemia impairs motivation in a progressive FR schedule of reinforcement in mice
Linden, Jérôme ULg; Plumier, Jean-Christophe ULg; Fassotte, Ludivine et al

in Behavioural Brain Research (2015), 279

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See detailSimulation of the elementary evolution operator with the motional states of an ion in an anharmonic trap
Santos, Ludovic; Justum, Yves; Vaeck, Nathalie et al

in The journal of chemical physics (2015), 142

Following a recent proposal of L. Wang and D. Babikov, J. Chem. Phys. 137, 064301 (2012), we theoretically illustrate the possibility of using the motional states of a Cd+ ion trapped in a slightly ... [more ▼]

Following a recent proposal of L. Wang and D. Babikov, J. Chem. Phys. 137, 064301 (2012), we theoretically illustrate the possibility of using the motional states of a Cd+ ion trapped in a slightly anharmonic potential to simulate the single-particle time-dependent Schrödinger equation. The simulated wave packet is discretized on a spatial grid and the grid points are mapped on the ion motional states which define the qubit network. The localization probability at each grid point is obtained from the population in the corresponding motional state. The quantum gate is the elementary evolution operator corresponding to the time-dependent Schrödinger equation of the simulated system. The corresponding matrix can be estimated by any numerical algorithm. The radio-frequency field able to drive this unitary transformation among the qubit states of the ion is obtained by multi-target optimal control theory. The ion is assumed to be cooled in the ground motional state and the preliminary step consists in initializing the qubits with the amplitudes of the initial simulated wave packet. The time evolution of the localization probability at the grids points is then obtained by successive applications of the gate and reading out the motional state population. The gate field is always identical for a given simulated potential, only the field preparing the initial wave packet has to be optimized for different simulations. We check the stability of the simulation against decoherence due to fluctuating electric fields in the trap electrodes by applying dissipative Lindblad dynamics. [less ▲]

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See detailAbnormal glomerular filtration rate in children, adolescents and young adults starts below 75 mL/min/1.73 m2
Pottel, Hans; Hoste, Liesbeth; DELANAYE, Pierre ULg

in Pediatric Nephrology : Journal of the International Pediatric Nephrology Association (2015), 30(5), 821-828

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See detailSoil redistribution and weathering controlling the fate of geochemical and physical carbon stabilization mechanisms in soils of an eroding landscape
Doetterl, Sebastien; Six, Johan; Bodé, Samuel et al

in Biogeosciences (2015)

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See detailOleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig.
Horcajada, M.-N.; Sanchez, Christelle ULg; Membrez Scalfo et al

in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society (2015), 23(1), 94-102

OBJECTIVE: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, on joint ageing and osteoarthritis (OA) development. DESIGN: Sixty 4-week-old Dunkin-Hartley ... [more ▼]

OBJECTIVE: To assess the potential protective effects of three polyphenols oleuropein, rutin and curcumin, on joint ageing and osteoarthritis (OA) development. DESIGN: Sixty 4-week-old Dunkin-Hartley guinea pigs were randomized into four groups and received daily during 31 weeks either standard guinea pig diet (control group) or a standard guinea pig diet enriched with oleuropein (0.025%), rutin (0.5%) or rutin/curcumin (0.5%/0.25%) association. Biomarkers of OA (Coll2-1, Coll2-1NO2, Fib3-1, Fib3-2, ARGS), as well as inflammation (PGE2) were quantified in the serum. Histological assessments of knee cartilage and synovial membrane were performed at week 4 (five young reference guinea pigs) and week 35. RESULTS: At week 35, guinea pigs in the control group spontaneously developed significant cartilage lesions with mild synovial inflammation. The histological scores of cartilage lesions and synovitis were well correlated with the increased level of serum biomarkers. Histologically, all treatments significantly reduced the cartilage degradation score (P < 0.01), but only oleuropein significantly decreased the synovial histological score (P < 0.05) and serum PGE2 levels (P < 0.01) compared to the control group. Coll2-1 was decreased by rutin and the combination of rutin/curcumin, Fib3-1 and Fib3-2 were only decreased by the rutin/curcumin mixture, while Coll2-1NO2 was significantly decreased by all treatments (P < 0.05). CONCLUSION: Oleuropein and rutin +/- curcumin significantly slowed down the progression of spontaneous OA lesions in guinea pigs. While no additive effect was seen in the curcumin + rutin group, the differential effects of oleuropein and rutin on inflammatory and cartilage catabolic markers suggest an interesting combination for future studies in OA protection. [less ▲]

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See detailMultiscale variability of amphipod assemblages in Posidonia oceanica meadows
Sturaro, Nicolas ULg; Lepoint, Gilles ULg; Vermeulen, Simon et al

in Journal of Sea Research (2015), 95

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and ... [more ▼]

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and conservation. Amphipod crustaceans are key organisms in seagrass ecosystems. However, little attention has been paid to the spatial scales at which amphipod assemblages may vary. We examined variability patterns of amphipod populations inhabiting Posidonia oceanica meadows, over spatial scales spanning four orders of magnitude (1 to 1000 metres) and for two consecutive years. This study reports the scales that contributed most to spatial variation of amphipod assemblages and explores the potential processes of the observed patterns, with particular emphasis on habitat features. The number of species, the diversity and the density of some species, exhibited high variation across years. Most species showed the highest spatial variation in density and biomass at small scales (~1 and 10 m). Based on density data, the structure of amphipod assemblages did not differ at any scales investigated. The patchiness that occurred at small scales may have been only weakly related to habitat features. Instead, we postulated that behavioural processes of amphipods were likely good explanatory factors. Although, the small scale spatial variability can be an important feature of amphipod assemblages in P. oceanica meadows, many patterns probably remained undetected as they may occur at scales smaller than those investigated. [less ▲]

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See detailNovel magneto-electric multiferroics from first-principles calculations
Varignon, Julien ULg; Bristowe, Nicholas ULg; Bousquet, Eric ULg et al

in Comptes Rendus Physique (2015), 16

Interest in first-principles calculations within the multiferroic community has been rapidly on the rise over the last decade. Initially considered as a powerful support to explain experimentally observed ... [more ▼]

Interest in first-principles calculations within the multiferroic community has been rapidly on the rise over the last decade. Initially considered as a powerful support to explain experimentally observed behaviours, the trend has evolved and, nowadays, density functional theory calculations have become also an essential predicting tool for identifying original rules to achieve multiferroism and design new magneto-electric compounds. This chapter aims at highlighting the key advances in the field of multiferroics, to which first-principles methods have contributed significantly. The essential theoretical developments that made this research possible are also briefly presented. [less ▲]

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See detailThe EChO science case
Tinetti, Giovanna; Drossart, Pierre; Eccleston, Paul et al

in ArXiv e-prints (2015), 1502

The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general ... [more ▼]

The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general population of planets in our Milky Way. The key science questions that urgently need addressing are therefore: What are exoplanets made of? Why are planets as they are? What causes the exceptional diversity observed as compared to the Solar System? EChO (Exoplanet Characterisation Observatory) has been designed as a dedicated survey mission for transit and eclipse spectroscopy capable of observing a large and diverse planet sample within its four-year mission lifetime. EChO can target the atmospheres of super-Earths, Neptune-like, and Jupiter-like planets, in the very hot to temperate zones (planet temperatures of 300K-3000K) of F to M-type host stars. Over the next ten years, several new ground- and space-based transit surveys will come on-line (e.g. NGTS, CHEOPS, TESS, PLATO), which will specifically focus on finding bright, nearby systems. The current rapid rate of discovery would allow the target list to be further optimised in the years prior to EChO's launch and enable the atmospheric characterisation of hundreds of planets. Placing the satellite at L2 provides a cold and stable thermal environment, as well as a large field of regard to allow efficient time-critical observation of targets randomly distributed over the sky. A 1m class telescope is sufficiently large to achieve the necessary spectro-photometric precision. The spectral coverage (0.5-11 micron, goal 16 micron) and SNR to be achieved by EChO, thanks to its high stability and dedicated design, would enable a very accurate measurement of the atmospheric composition and structure of hundreds of exoplanets. [less ▲]

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See detailIntensity of prolactinoma on T2-weighted magnetic resonance imaging: towards another gender difference.
KREUTZ, Julie ULg; VROONEN, Laurent ULg; Cattin, Françoise et al

in Neuroradiology (2015)

INTRODUCTION: Clinical presentations of prolactinomas are quite different between genders. In comparison with women's prolactinoma, those in men showed predominance of large tumors with high prolactin ... [more ▼]

INTRODUCTION: Clinical presentations of prolactinomas are quite different between genders. In comparison with women's prolactinoma, those in men showed predominance of large tumors with high prolactin (PRL) levels. This preponderance could be attributed to a greater proliferative potential of the tumors. Differences in magnetic resonance imaging (MRI) signal at diagnosis have not been yet clearly evaluated. METHODS: We conduct a retrospective study comparing MRI signal intensity (SI) on T2-weighted images (T2-WI) between 41 men and 41 women to investigate whether or not men prolactinoma present specific features. RESULTS: In addition to the size of the adenoma and PRL levels (P < 0001), prolactinomas in men also exhibit differences from those in women in signal on T2-WI on MRI (P < 0001). Women's prolactinomas are mostly of high SI on T2-WI while men's prolactinomas exhibit a more heterogeneous pattern of SI on T2-WI. Prolactinomas presenting with low SI on T2-WI are almost exclusively encountered in men. CONCLUSIONS: Presence of T2-WI hypointensities in pituitary adenoma can be predictive of a different subtype of prolactinoma almost encountered in men and possibly translate the presence of spherical amyloid deposits, in agreement with the literature. [less ▲]

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See detailValidation and Psychometric Properties of the French Versions of the Environmental Reward Observation Scale and of the Reward Probability Index
Wagener, Aurélie ULg; Blairy, Sylvie ULg

in Psychologica Belgica (2015)

Background: Low levels of environmental rewards have been related to depression on a number of occasions in the scientific literature. Two scales have been created to assess environmental rewards: the ... [more ▼]

Background: Low levels of environmental rewards have been related to depression on a number of occasions in the scientific literature. Two scales have been created to assess environmental rewards: the Environmental Reward Observation Scale (EROS) and the Reward Probability Index (RPI). This study aims to validate the French versions of these two scales. Method: 466 non-clinical adults completed an online survey assessing environmental rewards, depression, anxiety, activation, avoidance and behavioural systems. Confirmatory factor analyses were performed to assess the factorial structures of the French EROS and RPI. Results: A one-factor solution for the EROS and a two-factor solution for the RPI best fitted the data. High levels of internal consistency were found for both the EROS and the RPI. Convergent validity was also examined, revealing that high environmental rewards appear to be related to activation and behavioural activation system. Conclusion: The French versions of the EROS and the RPI appear to be reliable assessments of environmental rewards. [less ▲]

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See detailSpore assemblages from Upper Ordovician and Lowermost Silurian sediments recovered from the Qusaiba-1 shallow core hole, Qasim region, central Saudi Arabia
Wellman, Charles H.; Steemans, Philippe ULg; Miller, M.A.

in Review of Palaeobotany and Palynology (2015), 212

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See detail¿Podemos hablar de una postura del traductor?
Mogollon Zapata, Juan Manuel ULg

in Tropelías: Revista de Teoría de la Literatura y Literatura Comparada (2015), 24

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See detailCharge Redistribution Effects on the UV-VIS Spectra of Small Ligated Gold Clusters: a Computational Study
Lugo Preciado, Jesus Gustavo ULg; Schwanen, Valérie ULg; Fresch, Barbara ULg et al

in Journal of Physical Chemistry C (2015), 119(20), 10969-10980

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See detailHot topic: Innovative lactation-stage-dependent prediction of methane emissions from milk mid-infrared spectra
Vanlierde, Amélie; Vanrobays, Marie-Laure ULg; Dehareng, Frédéric et al

in Journal of Dairy Science (2015), In press

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See detailEvaluation and Comparison of Anatomical Landmark Detection Methods for Cephalometric X-Ray Images: A Grand Challenge
Ching Wei, Wang; Cheng-Ta, Huang; Meng-Che, Hsieh et al

in IEEE Transactions on Medical Imaging (2015)

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See detailEffets du froid sur les stades précoces de développement du maïs (Zea mays)
Riva-Roveda, Laetitia ULg; Périlleux, Claire ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), 42-52

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See detailThe Cellobiose Sensor CebR is the Gatekeeper of Streptomyces scabies Pathogenicity
Francis, Isolde; Jourdan, Samuel ULg; Fanara, Steven ULg et al

in MBio (2015)

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See detailBiotechnological uses of RNAi in plants: Risk assessment considerations
Casacuberta, J. M.; Devos, Y.; du Jardin, Patrick ULg et al

in Trends in Biotechnology (2015), 33(3), 145-147

RNAi offers opportunities to generate new traits in genetically modified (GM) plants. Instead of expressing novel proteins, RNAi-based GM plants reduce target gene expression. Silencing of off-target ... [more ▼]

RNAi offers opportunities to generate new traits in genetically modified (GM) plants. Instead of expressing novel proteins, RNAi-based GM plants reduce target gene expression. Silencing of off-target genes may trigger unintended effects, and identifying these genes would facilitate risk assessment. However, using bioinformatics alone is not reliable, due to the lack of genomic data and insufficient knowledge of mechanisms governing mRNA-small (s)RNA interactions. © 2014 Elsevier Ltd. [less ▲]

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See detailMedical education and training in geriatrics in the 21st centrury. Where do we come from - where do we go ?
Roller, Regina Elisabeth; PETERMANS, Jean ULg

in European Geriatric Medicine (2015)

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See detailKnowledge of the concept Light Rail Transit: Exploring its relevance and identification of the determinants of various knowledge levels
Creemers, Lieve; Tormans, Hans; Bellemans, Tom et al

in Transportation Research. Part A : Policy & Practice (2015), 74

This paper explores the knowledge of the concept ‘Light Rail Transit’ (LRT) in the context of implementing a Light Rail system in a (sub)-urban region. To this end, three models are estimated: a first ... [more ▼]

This paper explores the knowledge of the concept ‘Light Rail Transit’ (LRT) in the context of implementing a Light Rail system in a (sub)-urban region. To this end, three models are estimated: a first model to explore the role of knowledge on modal choice, a second one to identify the determinants of the level of knowledge and a third model to identify the determinants of a cognitive mismatch between actual (real) knowledge and perceived knowledge. The first model (a negative binomial regression model) underlines the significant relation between knowledge of the concept LRT and modal choice. Given the lack of knowledge of the concept ‘Light Rail Transit’ revealed by the descriptive results, it is of crucial importance to raise the level of knowledge. Knowledge acquisition can be based on transit experiences and information provision. To explore how information campaigns should be constructed and which target groups should be approached, the factors influencing travelers’ knowledge and the determinants of a cognitive mismatch are identified by a Multinomial Logit Model (MNL-model) and a binary logit model. The results show that various socio-economic variables as well as socio-psychological variables are significantly influencing actual knowledge and significantly influencing a cognitive mismatch. Among these variables, employment, gender, perception of ticket price of Public Transit (PT) and expectations with regard to seat availability in the LRT-vehicle are the most influential ones. [less ▲]

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See detailWeight Management in Type 2 Diabetes: Current and Emerging Approaches to Treatment.
Van Gaal, Luc; Scheen, André ULg

in Diabetes care (2015), 38(6), 1161-1172

Diabetes is a growing global health concern, as is obesity. Diabetes and obesity are intrinsically linked: obesity increases the risk of diabetes and also contributes to disease progression and ... [more ▼]

Diabetes is a growing global health concern, as is obesity. Diabetes and obesity are intrinsically linked: obesity increases the risk of diabetes and also contributes to disease progression and cardiovascular disease. Although the benefits of weight loss in the prevention of diabetes and as a critical component of managing the condition are well established, weight reduction remains challenging for individuals with type 2 diabetes due to a host of metabolic and psychological factors. For many patients, lifestyle intervention is not enough to achieve weight loss, and alternative options, such as pharmacotherapy, need to be considered. However, many traditional glucose-lowering medications may lead to weight gain. This article focuses on the potential of currently available pharmacological strategies and on emerging approaches in development to support the glycemic and weight-loss goals of individuals with type 2 diabetes. Two pharmacotherapy types are considered: those developed primarily for blood glucose control that have a favorable effect on body weight and those developed primarily to induce weight loss that have a favorable effect on blood glucose control. Finally, the potential of combination therapies for the management of obese patients with type 2 diabetes is discussed. [less ▲]

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See detailLes vers à soie sauvages à Madagascar : Enjeux écologiques et socio-économiques
Verheggen, François ULg; Haubruge, Eric ULg; Bogaert, Jan ULg

in Entomologie Faunistique = Faunistic Entomology (2015), 68

We here introduce the book « The Malagasy silk moths: ecological and socio-economic challenges » published in 2013 by the Presses agronomiques de Gembloux (Belgium). This book reflects the achievements ... [more ▼]

We here introduce the book « The Malagasy silk moths: ecological and socio-economic challenges » published in 2013 by the Presses agronomiques de Gembloux (Belgium). This book reflects the achievements and scientific activities of the project "Sustainable Management and valorisation of the endemic silkworm Borocera cajani in forest areas in the Antananarivo region" funded by Commission universitaire pour le Développement (CUD - CIUF). [less ▲]

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See detailMaximal bifix decoding
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Discrete Mathematics (2015), 338(5), 725742

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See detailMaterial Flow Visualization Friction Stir Welding via Particle Tracing
Dialami, Narges; Chiumenti, Michele; Cervera, Miguel et al

in International Journal of Material Forming (2015), 8

This work deals with the modeling of the material flow in Friction Stir Welding (FSW) processes using particle tracing method. For the computation of particle trajectories, three accurate and ... [more ▼]

This work deals with the modeling of the material flow in Friction Stir Welding (FSW) processes using particle tracing method. For the computation of particle trajectories, three accurate and computationally efficient integration methods are implemented within a FE model for FSW process: the Backward Euler with Sub-stepping (BES), the 4-th order Runge-Kutta (RK4) and the Back and Forth Error Compensation and Correction (BFECC) methods. Firstly, their performance is compared by solving the Zalesak’s disk benchmark. Later, the developed methodology is applied to some FSW problems providing a quantitative 2D and 3D view of the material transport in the process area. The material flow pattern is compared to the experimental evidence. [less ▲]

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See detailFe–Ti–V–P ore deposits associated with Proterozoic massif-type anorthosites and related rocks
Charlier, Bernard ULg; Namur, Olivier; Bolle, Olivier ULg et al

in Earth-Science Reviews (2015), 141(0), 56-81

Magmatic rocks containing economic concentrations of iron, titanium, vanadium and phosphorous are commonly associated with massif-type anorthosites and related rocks. This rock association is part of the ... [more ▼]

Magmatic rocks containing economic concentrations of iron, titanium, vanadium and phosphorous are commonly associated with massif-type anorthosites and related rocks. This rock association is part of the anorthosite–mangerite–charnockite–(rapakivi-)granite suites that are restricted to the Proterozoic. Understanding the geochemistry and emplacement mechanisms of ilmenite, magnetite and apatite ore deposits is crucial for exploration, efficient mining operations and ore processing. This review discusses the controlling factors on the grade of an ore, its mineralogy, and its major and trace element distribution. We present petrogenetic models of currently mined deposits (Lac Tio, Tellnes, Damiao) and discuss the characteristics of minor ore bodies from anorthosite provinces worldwide (Grenville, North China Craton, East European Craton, Rogaland, Laramie). Models of formation of anorthosite and related rocks are presented, as well as the nature of the possible parental magmas of the suite. A mineralogical classification of Fe–Ti ores is proposed: (1) Gabbro-noritic ilmenite ore ± apatite ± magnetite; (2) Ti-magnetite-dominated ore; (3) Nelsonite (Fe–Ti oxides + apatite); and (4) Rutile-ilmenite ore. The stability of ilmenite and magnetite is then critically reviewed and the influence of various factors, particularly oxygen fugacity and crystallization pressure, is examined. We discuss liquidus compositions of Fe–Ti oxides and the behavior of important trace elements such as Cr and V, both of which are sensitive to fO2 variations. Post-cumulus evolution of both oxides can occur due to re-equilibration with trapped liquid, re-equilibration with ferromagnesian silicates, exsolution, oxidation, reaction between ilmenite and magnetite, and metamorphic overprinting. These various processes are described and their effects on the oxide geochemistry are emphasized. Several potential ore-forming processes have been invoked and can explain the formation of huge concentration of ilmenite, ± magnetite, ± apatite. Fractional crystallization can be combined with crystal sorting and plagioclase buoyancy to produce relative enrichment of dense ore minerals. Silicate liquid immiscibility can segregate conjugate Si-rich and Fe-rich melts, the latter being enriched in Fe–Ti–P. Magma mixing can produce hybrid magmas located in a single-phase field of the phase diagram and precipitate a pure ilmenite cumulate. Alternative processes are also described, such as ejection of Fe–Ti-enriched residual melts by filter-pressing and compaction, solid-state remobilization of ilmenite in veins, and hydrothermal transport of Fe and Ti from the host anorthosite followed by concentration in veins and lenticular ore bodies. The magnetic properties of Fe–Ti ore deposits present contrasting signatures, depending on whether the natural remanent magnetization is dominated by hemo-ilmenite or multi-domain magnetite. Micro- and macro-scale deformation features of ore rocks are intimately correlated with magma emplacement, and with ballooning of the anorthosite diapir associated with gravitational sagging of dense ore bodies. Exploration perspectives show that oxide-apatite gabbronorites are interesting targets because ilmenite in these rocks is poorer in Cr and Mg, and because the Ti-resource may be combined with apatite and vanadiferous magnetite. [less ▲]

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See detailDiabetes is a risk factor for knee osteoarthritis progression
Eymard, F; Parsons, C; Edwards, M et al

in Osteoarthritis and Cartilage (2015), 23

Purpose Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology ... [more ▼]

Purpose Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology of knee osteoarthritis (OA). We investigated their impact on radiographic progression by an annualised measure of the joint space narrowing (JSN) of the medial tibiofemoral compartment. Methods 559 patients older than 50 years with symptomatic knee OA were recruited for the placebo arm of the SEKOIA trial. The presence of diabetes, hypertension and dyslipidemia was determined at baseline interview. BMI was calculated, obesity was considered >30 kg/m2. MetS was defined by the sum of metabolic factors ≥3. Minimal medial tibiofemoral joint space on plain radiographs was measured by an automated method at baseline and then annually for up to 3 years. Results The mean age of patients was 62.8 [62.2-63.4] years; 392 were women. A total of 43.8% was obese, 6.6% had type 2 diabetes, 45.1% hypertension, 27.6% dyslipidemia and 13.6% MetS. Mean annualised JSN was greater for patients with type 2 diabetes than without diabetes (0.26 [-0.35 - -0.17] vs. 0.14 [-0.16 - -0.12] mm; p=0.001). This association remained significant after adjustment for sex, age, BMI, hypertension and dyslipidemia (p=0.018). In subgroup analysis, type 2 diabetes was a significant predictor of JSN in males but not females. The other metabolic factors and MetS were not associated with annualised JSN. Conclusion Type 2 diabetes was a predictor of joint space reduction in men with established knee OA. No relationships were found between MetS or other metabolic factors and radiographic progression. [less ▲]

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See detailLe secret des plus grands "géants" en partie percé
Beckers, Albert ULg

in Vaisseaux, Coeur, Poumons (2015), 20(4),

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See detailOstéoporose et Médecine Personnalisée
Reginster, Jean-Yves ULg; NEUPREZ, Audrey ULg; LECART, Marie-Paule ULg et al

in Revue Médicale de Liège (2015), 70(5-6), 321-324

Osteoporosis is at the very early stages of the implementation of personalized medicine. However, the development of FRAX®, an algorithm offering the opportunity to calculate, in an individual patient ... [more ▼]

Osteoporosis is at the very early stages of the implementation of personalized medicine. However, the development of FRAX®, an algorithm offering the opportunity to calculate, in an individual patient, his/her 10-year fracture risk improves the decision process on the appropriateness to initiate a pharmacological treatment. This algorithm helps the physician to select drugs which are active on non-vertebral fractures only in high risk patients. Taking into consideration patients’ preferences, when selecting a therapeutic option, will improve long term adherence and subsequently efficacy and efficiency of the treatments. Attempts to define the natural course of osteoporosis or the response to therapy in individual patients by assessing their genetic profile remains, so far, inconclusive. [less ▲]

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See detailA New Approach to the 2-Regularity of the ℓ-Abelian Complexity of 2-Automatic Sequences
Parreau, Aline; Rigo, Michel ULg; Rowland, Eric ULg et al

in The Electronic Journal of Combinatorics (2015), 22(1), 127

We prove that a sequence satisfying a certain symmetry property is 2-regular in the sense of Allouche and Shallit, i.e., the Z-module generated by its 2-kernel is finitely generated. We apply this theorem ... [more ▼]

We prove that a sequence satisfying a certain symmetry property is 2-regular in the sense of Allouche and Shallit, i.e., the Z-module generated by its 2-kernel is finitely generated. We apply this theorem to develop a general approach for studying the l-abelian complexity of 2-automatic sequences. In particular, we prove that the period-doubling word and the Thue--Morse word have 2-abelian complexity sequences that are 2-regular. Along the way, we also prove that the 2-block codings of these two words have 1-abelian complexity sequences that are 2-regular. [less ▲]

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See detailCompte rendu de l'ouvrage d'I. Mazzini, Letteratura e medicina nel mondo antico, Rome: Università La Sapienza, 2011
Ricciardetto, Antonio ULg

in Latomus : Revue d'Etudes Latines (2015), 74(1), 280-282

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See detailError analysis of generalized-alpha Lie group time integration methods for constrained mechanical systems
Arnold, Martin; Bruls, Olivier ULg; Cardona, Alberto

in Numerische Mathematik (2015), 129(1), 149-179

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order ... [more ▼]

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order systems in linear spaces. Recently, they were extended to constrained systems in flexible multibody dynamics that have a configuration space with Lie group structure. In the present paper, the convergence of these Lie group methods is analysed by a coupled one-step error recursion for differential and algebraic solution components. It is shown that spurious oscillations in the transient phase result from order reduction that may be avoided by a perturbation of starting values or by index reduction. Numerical tests for a benchmark problem from the literature illustrate the results of the theoretical investigations. [less ▲]

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