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See detailPharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor.
Scheen, André ULg

in Clinical pharmacokinetics (2014), 53(3), 213-25

Empagliflozin is an orally active, potent and selective inhibitor of sodium glucose co-transporter 2 (SGLT2), currently in clinical development to improve glycaemic control in adults with type 2 diabetes ... [more ▼]

Empagliflozin is an orally active, potent and selective inhibitor of sodium glucose co-transporter 2 (SGLT2), currently in clinical development to improve glycaemic control in adults with type 2 diabetes mellitus (T2DM). SGLT2 inhibitors, including empagliflozin, are the first pharmacological class of antidiabetes agents to target the kidney in order to remove excess glucose from the body and, thus, offer new options for T2DM management. SGLT2 inhibitors exert their effects independently of insulin. Following single and multiple oral doses (0.5-800 mg), empagliflozin was rapidly absorbed and reached peak plasma concentrations after approximately 1.33-3.0 h, before showing a biphasic decline. The mean terminal half-life ranged from 5.6 to 13.1 h in single rising-dose studies, and from 10.3 to 18.8 h in multiple-dose studies. Following multiple oral doses, increases in exposure were dose-proportional and trough concentrations remained constant after day 6, indicating a steady state had been reached. Oral clearance at steady state was similar to corresponding single-dose values, suggesting linear pharmacokinetics with respect to time. No clinically relevant alterations in pharmacokinetics were observed in mild to severe hepatic impairment, or in mild to severe renal impairment and end-stage renal disease. Clinical studies did not reveal any relevant drug-drug interactions with several other drugs commonly prescribed to patients with T2DM, including warfarin. Urinary glucose excretion (UGE) rates were higher with empagliflozin versus placebo and increased with dose, but no relevant impact on 24-h urine volume was observed. Increased UGE resulted in proportional reductions in fasting plasma glucose and mean daily glucose concentrations. [less ▲]

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See detailMitochondrial encephalomyopathy with cytochrome c oxidase deficiency caused by a novel mutation in the MTCO1 gene.
Debray, François-Guillaume ULg; Seneca, Sara; Gonce, Michel et al

in Mitochondrion (2014)

Cytochrome c oxidase (COX) deficiency is one of the most common respiratory chain deficiencies. A woman was presented at the age of 18y with acute loss of consciousness, non-convulsive status epilepticus ... [more ▼]

Cytochrome c oxidase (COX) deficiency is one of the most common respiratory chain deficiencies. A woman was presented at the age of 18y with acute loss of consciousness, non-convulsive status epilepticus, slow neurological deterioration, transient cortical blindness, exercise intolerance, muscle weakness, hearing loss, cataract and cognitive decline. Muscle biopsy revealed ragged-red fibers, COX negative fibers and a significant decreased activity of complex IV in a homogenate. Using next generation massive parallel sequencing of the mtDNA, a novel heteroplasmic mutation was identified in MTCO1, m.7402delC, causing frameshift and a premature termination codon. Single fiber PCR showed co-segregation of high mutant load in COX negative fibers. Mutation in mitochondrially encoded complex IV subunits should be considered in mitochondrial encephalomyopathies and COX negative fibers after the common mtDNA mutations have been excluded. [less ▲]

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See detailThe value of disturbance-tolerant cercopithecine monkeys as seed dispersers in degraded habitats
Albert, Aurélie; McConkey, Kim; Savini, Tommaso ULg et al

in Biological Conservation (2014), 170

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See detailL'électroneuromyographie dans la pathologie de la face dorsale du pied
WANG, François-Charles ULg

in Médecine et Chirurgie du Pied = Foot Medicine and Surgery (2014), (30), 86-89

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See detailGlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolysporaerythraea
Li-Li, Yao; Cheng-Heng, Liao; Gang, Huang et al

in Applied Microbiology and Biotechnology (2014)

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See detailWhich incretin-based therapy for type 2 diabetes?
Scheen, André ULg

in Lancet (2014)

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See detailA Givetian tintinnid-like palynomorph from Libya.
Steemans, Philippe ULg; Breuer, P.; Ville de Goyet, F. de et al

in Review of Palaeobotany and Palynology (2014), ?

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See detailGouvy/Bovigny : empierrement à Courtil "Obourcy"
Drailly, Christelle; Thiebaux, Aurélie ULg; Goemaere, Eric

in Chronique de l'Archéologie Wallonne (2014), 21

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See detailDensity estimates and nesting-site selection in chimpanzees of the Nimba Mountains, Côte d'Ivoire and Guinea
Granier, Nicolas ULg; Hambuckers, Alain ULg; Matsuzawa et al

in American Journal of Primatology (2014)

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked ... [more ▼]

We investigated nesting behavior of non habituated chimpanzees populating the Nimba Mountains to document their abundance and their criterions of nesting-site selection. During a 19-month study we walked 80 km of transects and recces each month, and recorded 764 nests (mean group size = 2.23 nests) along with characteristics of vegetation structure and composition, topography and seasonality. Population density estimated with two nest count methods ranged between 0.14 and 0.65 chimpanzee/km2. These values are lower than previous estimates, emphasizing the necessity of protecting remaining wild ape populations. Chimpanzees built nests in 108 tree species out of 437 identified, but 2.3% of total species comprised 52% of nests. Despite they preferred nesting in trees of 25-29 cm DBH and at a mean height of 8.02 m, we recorded an important proportion of terrestrial nests (8.2%) that may reflect a cultural trait of Nimba chimpanzees. A logistic model of nest presence formulated as a function of 12 habitat variables revealed preference for gallery and mountain forests rather than lowland forest, and old-growth forest rather than secondary forests. They nested more frequently in the study area during the dry season (December-April). The highest probability of observing nests was at 770 m altitude, particularly in steep locations (mean ground declivity = 15.54%). Several of the reported nest characteristics combined with the existence of 2 geographically separated clusters of nest, suggest that the study area constitutes the non-overlapping peripheral areas of 2 distinct communities. This nest-based study led us to findings on the behavioral ecology of Nimba chimpanzees, which constitute crucial knowledge to implement efficient and purpose-built conservation. [less ▲]

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See detailEffets de deux associations culturales avec du blé sur les populations de pucerons (Homoptera: Aphididae) et d’auxiliaires aphidiphages: étude préliminaire menée en Chine
Chevalier Mendes Lopes, Thomas ULg; Bosquée, Emilie ULg; Honba, David et al

in Entomologie Faunistique = Faunistic Entomology (2014)

Crop associations have several advantages when the plant species and the crop production methods, including the harvesting, are well selected. This preliminary study was conducted in the Shandong province ... [more ▼]

Crop associations have several advantages when the plant species and the crop production methods, including the harvesting, are well selected. This preliminary study was conducted in the Shandong province (China) to better characterize the effect of wheat (Triticum aestivum L.)/oilseed rape (Brassica napus L.) and wheat/pea (Pisum sativum L.) associations on the aphid and aphidophagous beneficial populations. Aphids observed on wheat tillers were more abundant in the pure stand of wheat during the two weeks prior to their population peak, compared with crop associations. Considering the aphidophagous beneficials, more ladybirds were observed in the associations, compared with the pure crop stand. Yellow pan traps were also used to assess the diversity and abundance of adult beneficial species. The parasitoid species Aphidius gifuensis (Ashmead) was prevalent. Among predators, Propylea japonica (Thunberg) and Harmonia axyridis (Pallas) were the most abundant species. This study contributes to better understand the potential of crop associations with wheat as a sustainable method to control aphid populations in this region of China. [less ▲]

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See detailA modified DOI-based method to statistically estimate the depth of investigation of dc resistivity surveys
Deceuster, J.; Etienne, A.; Robert, Tanguy et al

in Journal of Applied Geophysics (2014), 103

Several techniques are available to estimate the depth of investigation or to identify possible artifacts in dc resistivity surveys. Commonly, the depth of investigation (DOI) is mainly estimated by using ... [more ▼]

Several techniques are available to estimate the depth of investigation or to identify possible artifacts in dc resistivity surveys. Commonly, the depth of investigation (DOI) is mainly estimated by using an arbitrarily chosen cut-off value on a selected indicator (resolution, sensitivity or DOI index). Ranges of cut-off values are recommended in the literature for the different indicators. However, small changes in threshold values may induce strong variations in the estimated depths of investigation. To overcome this problem, we developed a new statistical method to estimate the DOI of dc resistivity surveys based on a modified DOI index approach. This method is composed of 5 successive steps. First, two inversions are performed by using different resistivity reference models for the inversion (0.1 and 10 times the arithmetic mean of the logarithm of the observed apparent resistivity values). Inversion models are extended to the edges of the survey line and to a depth range of three times the pseudodepth of investigation of the largest array spacing used. In step 2, we compute the histogram of a newly defined scaled DOI index. Step 3 consists of the fitting of the mixture of two Gaussian distributions (G1 and G2) to the cumulative distribution function of the scaled DOI index values. Based on this fitting, step 4 focuses on the computation of an interpretation index (II) defined for every cell j of the model as the relative probability density that the cell j belongs to G1, which describes the Gaussian distribution of the cells with a scaled DOI index close to 0.0. In step 5, a new inversion is performed by using a third resistivity reference model (the arithmetic mean of the logarithm of the observed apparent resistivity values). The final electrical resistivity image is produced by using II as alpha blending values allowing the visual discrimination between well-constrained areas and poorly-constrained cells. The efficiency of the proposed methodology is assessed on synthetic and field data. By using synthetic benchmark analysis, we demonstrate that the selected well-constrained cells are well-reconstructed in size and shape as well as in resistivity contrasts. Compared to the existing image appraisal tools, the proposed statistical method allows the identification of the statistically well-constrained cells of the model without using any arbitrary cut-off value. Using this statistical method in combination with the resolution, when interpreting dc resistivity surveys, provides the geophysicist valuable information to avoid over- or misinterpretation of ERT images. [less ▲]

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See detailWhen the value of gold is zero.
Chase, J. Geoffrey; Moeller, Knut; Shaw, Geoffrey M. et al

in BMC research notes (2014), 7

This manuscript presents the concerns around the increasingly common problem of not having readily available or useful "gold standard" measurements. This issue is particularly important in critical care ... [more ▼]

This manuscript presents the concerns around the increasingly common problem of not having readily available or useful "gold standard" measurements. This issue is particularly important in critical care where many measurements used in decision making are surrogates of what we would truly wish to use. However, the question is broad, important and applicable in many other areas.In particular, a gold standard measurement often exists, but is not clinically (or ethically in some cases) feasible. The question is how does one even begin to develop new measurements or surrogates if one has no gold standard to compare with?We raise this issue concisely with a specific example from mechanical ventilation, a core bread and butter therapy in critical care that is also a leading cause of length of stay and cost of care. Our proposed solution centers around a hierarchical validation approach that we believe would ameliorate ethics issues around radiation exposure that make current gold standard measures clinically infeasible, and thus provide a pathway to create a (new) gold standard. [less ▲]

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See detailOn the policy implications of changing longevity
Pestieau, Pierre ULg; Ponthiere, Grégory ULg

in CESifo Ecoonmic Studies (2014), 60

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See detailCurrent systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system
Ciais, P.; Dolman, A. J.; Bombelli, A. et al

in Biogeosciences (2014), 11(13), 3547--3602

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify ... [more ▼]

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires transformational advances from the existing sparse, exploratory framework towards a dense, robust, and sustained system in all components: anthropogenic emissions, the atmosphere, the ocean, and the terrestrial biosphere. The paper is addressed to scientists, policymakers, and funding agencies who need to have a global picture of the current state of the (diverse) carbon observations.We identify the current state of carbon observations, and the needs and notional requirements for a global integrated carbon observation system that can be built in the next decade. A key conclusion is the substantial expansion of the ground-based observation networks required to reach the high spatial resolution for CO2 and CH4 fluxes, and for carbon stocks for addressing policy-relevant objectives, and attributing flux changes to underlying processes in each region. In order to establish flux and stock diagnostics over areas such as the southern oceans, tropical forests, and the Arctic, in situ observations will have to be complemented with remote-sensing measurements. Remote sensing offers the advantage of dense spatial coverage and frequent revisit. A key challenge is to bring remote-sensing measurements to a level of long-term consistency and accuracy so that they can be efficiently combined in models to reduce uncertainties, in synergy with groundbased data. Bringing tight observational constraints on fossil fuel and land use change emissions will be the biggest challenge for deployment of a policy-relevant integrated carbon observation system. This will require in situ and remotely sensed data at much higher resolution and density than currently achieved for natural fluxes, although over a small land area (cities, industrial sites, power plants), as well as the inclusion of fossil fuel CO2 proxy measurements such as radiocarbon in CO2 and carbon-fuel combustion tracers. Additionally, a policy-relevant carbon monitoring system should also provide mechanisms for reconciling regional top-down (atmosphere-based) and bottom-up (surface-based) flux estimates across the range of spatial and temporal scales relevant to mitigation policies. In addition, uncertainties for each observation data-stream should be assessed. The success of the system will rely on long-term commitments to monitoring, on improved international collaboration to fill gaps in the current observations, on sustained efforts to improve access to the different data streams and make databases interoperable, and on the calibration of each component of the system to agreed-upon international scales. [less ▲]

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See detailReturn-to-play critera after hamstring injury: actual medicine practice professional soccer teams
Delvaux, François ULg; Rochcongar, p; Bruyère, Olivier ULg et al

in Journal of Sports Science & Medicine (2014), 13

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See detailRating Network Paths for Locality-Aware Overlay Construction and Routing
Du, Wei; Liao, Yongjun ULg; Tao, Narisu et al

in IEEE/ACM Transactions on Networking (2014)

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse ... [more ▼]

This paper investigates the rating of network paths, i.e. acquiring quantized measures of path properties such as round-trip time and available bandwidth. Comparing to finegrained measurements, coarse-grained ratings are appealing in that they are not only informative but also cheap to obtain. Motivated by this insight, we firstly address the scalable acquisition of path ratings by statistical inference. By observing similarities to recommender systems, we examine the applicability of solutions to recommender system and show that our inference problem can be solved by a class of matrix factorization techniques. A technical contribution is an active and progressive inference framework that not only improves the accuracy by selectively measuring more informative paths but also speeds up the convergence for available bandwidth by incorporating its measurement methodology. Then, we investigate the usability of rating-based network measurement and inference in applications. A case study is performed on whether locality awareness can be achieved for overlay networks of Pastry and BitTorrent using inferred ratings. We show that such coarse-grained knowledge can improve the performance of peer selection and that finer granularities do not always lead to larger improvements. [less ▲]

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See detailValidation of real-time PCR for detection of six major pathogens in seafood products
Taminiau, Bernard ULg; Korsak Koulagenko, Nicolas ULg; Lemaire et al

in Food Control (2014), 44

Seafood can pose a public health concern to consumers. It is often consumed rawand may be contaminated with several foodborne pathogens. In order to guarantee the safety of seafood, real-time polymerase ... [more ▼]

Seafood can pose a public health concern to consumers. It is often consumed rawand may be contaminated with several foodborne pathogens. In order to guarantee the safety of seafood, real-time polymerase chain reaction (PCR) protocols may be used as these enable results to be provided within 24 h. The first goal of our work was to develop real-time PCR protocols enabling the detection of six foodborne pathogens that may be present in seafood products (Campylobacter jejuni, Campylobacter coli, enterohemorrhagic Escherichia coli, Salmonella spp., Vibrio parahaemolyticus, and Vibrio vulnificus). The corresponding gene targets were: 50S/VS1, rfbE, ttr, tlh, and vvp. A multiplex PCR was also developed to detect the virulence genes of V. parahaemolyticus: tdh and trh. A total of 420 bacterial strains belonging to four different genera/strains were used in this study. Sensitivity and specificity were always 100%, except in the case of Salmonella spp., where three strains were not detected by our PCR protocols. The second objective of our work was to assess the detection limit of our real-time PCR protocols on artificially contaminated seafood products (raw shrimps, cooked shrimps, and raw mussels), purchased in public stores. Six different levels of contamination were assayed in four replicates for each matrix. The real-time PCR protocols enabled a better level of detection than the ISO methods, except for Salmonella in raw shrimps and for V. vulnificus in shrimps (raw and cooked). The estimated level of detection was between 1 and 47 cfu/25 g sample for the ISO norms and between 1 and 315 cfu/25 g sample for the realtime PCR protocols tailored in our work. The real-time PCRs developed in our work allowed for good selectivity, sensitivity, and specificity. The sensitivity on seafood products was estimated at a level of 100%, except for Salmonella (97%). In the spiking assays, the levels of detection were lower with the real-time PCR protocol than those obtained with the ISO method. This was not the case for V. vulnificus in raw and cooked shrimps and for Salmonella in raw shrimps. These real-time PCR protocols appear to be good alternative methods for surveillance of seafood products to ensure the absence of foodborne pathogens. One additional conclusion is that laboratories have to use enrichment media that are compatible with those recommended by ISO standards. This may facilitate the isolation of the pathogen if the real-time PCR protocol gives a suspect positive signal during the first step of the seafood analysis. [less ▲]

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See detailPharmacotherapie du sujet agee: primum non nocere!
Scheen, André ULg

in Revue medicale de Liege (2014), 69(5-6), 282-6

Elderly patients, having various chronic diseases, are generally exposed to polypharmacy that may lead to potential adverse events. The latter may be explained by pharmacokinetic and pharmacodynamic ... [more ▼]

Elderly patients, having various chronic diseases, are generally exposed to polypharmacy that may lead to potential adverse events. The latter may be explained by pharmacokinetic and pharmacodynamic particularities that render elderly individuals more vulnerable when exposed to certain medications. Recruitment of elderly patients in clinical trials is often limited, so that it is not always easy to determine the real benefit/risk ratio of pharmacotherapy in this population. Obviously, iatrogenicity is quite frequent. Therefore, in front of unexplained alterations of health status in an elderly individual, the physician should consider the possibility of a drug adverse effect. Because of this situation, the physician should envisage a reasonable drug prescription in an elderly patient. Especially, not only the initiation of drug therapy should be carefully analyzed, but also the opportunity to eventually stop a medication that may be useless or even dangerous. Rather polypharmacy per se, it is the inappropriate prescription that should be avoided in the elderly. [less ▲]

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See detailSECOND ORDER SYMMETRIES OF THE CONFORMAL LAPLACIAN
Michel, Jean-Philippe ULg; Radoux, Fabian ULg; Silhan, Josef

in Symmetry, Integrability and Geometry: Methods and Applications [=SIGMA] (2014), 10(016), 26

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by ... [more ▼]

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by differential operators of second order. They are constructed from conformal Killing 2-tensors satisfying a natural and conformally invariant condition. As a consequence, we get also the classification of the second order symmetries of the conformal Laplacian. Our results generalize the ones of Eastwood and Carter, which hold on conformally flat and Einstein manifolds respectively. We illustrate our results on two families of examples in dimension three. [less ▲]

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See detailFragmentation and isomerization due to field heating in traveling wave ion mobility
Morsa, Denis ULg; Gabelica, Valérie ULg; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2014), 25(6), 1384-1393

During their travel inside a traveling wave ion mobility cell (TW IMS), ions are susceptible to heating because of the presence of high intensity electric fields. Here, we report effective temperatures T ... [more ▼]

During their travel inside a traveling wave ion mobility cell (TW IMS), ions are susceptible to heating because of the presence of high intensity electric fields. Here, we report effective temperatures T eff,vib obtained at the injection and inside the mobility cell of a SYNAPT G2 HDMS spectrometer for different probe ions: benzylpyridinium ions and leucine enkephalin. Using standard parameter sets, we obtained a temperature of ~800 K at injection and 728 ± 2 K into the IMS cell for p-methoxybenzylpyridinium. We found that T eff,vib inside the cell was dependent on the separation parameters and on the nature of the analyte. While the mean energy of the Boltzmann distributions increases with ion size, the corresponding temperature decreases because of increasing numbers of vibrational normal modes. We also investigated conformational rearrangements of 7+ ions of cytochrome c and reveal isomerization of the most compact structure, therefore highlighting the effects of weak heating on the gas-phase structure of biologically relevant ions. [less ▲]

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See detailVibronic Valence and Rydberg Transitions in Geminal Chloro-Fluoro-Ethene (1,1-C2H2FCl). A Spectroscopic and Quantum Chemical Investigation.
Locht, Robert ULg; Dehareng, Dominique ULg; Leyh, Bernard ULg

in Molecular Physics (2014), 112(11), 1520-1539

The vacuum UV photoabsorption spectrum of 1,1-C2H2FCl has been examined in detail between 5 eV and 15 eV photon energy by using synchrotron radiation dispersed by three different monochromators. Quantum ... [more ▼]

The vacuum UV photoabsorption spectrum of 1,1-C2H2FCl has been examined in detail between 5 eV and 15 eV photon energy by using synchrotron radiation dispersed by three different monochromators. Quantum chemical calculations are performed to help in the analysis of the valence/Rydberg transitions region centered at 7.05 eV including the 3a”(pi)→pi* and the 3a” (pi*)→3s Rydberg transitions. Interactions between states involving transitions to the 3s, 4d and sigma* orbitals are identified. A vibrational analysis is proposed for the structures belonging to these transitions. For the pi(3a”)→pi* transition, one vibrational progression is observed with ω3=1410±50 cm-1 and its lowest excitation energy is determined at about 6.398±0.003 eV. The pi(3a”)→3s Rydberg transition is characterized by a single progression with ω3= 1410±80 cm-1 likely starting at about 6.45 eV. These vibrations are ascribed to the C=C stretching motion. The abundant structure observed in the spectrum between 7.8 eV and 10.5 eV has been analyzed in terms of vibronic transitions to ns (δ= 0.97), np (δ= 0.63 and 0.40) and nd (δ= 0.13 and -0.11) Rydberg states which belong to series converging to the 1,1-C2H2FCl+( 2A”) ionic ground state. The analysis of the vibrational structure of the individual Rydberg states has been attempted leading to average values of the wavenumbers ω3= 1 420±20 cm-1, ω7= 720±50 cm-1 and ω9= 390±50 cm-1. Between 10.5 eV and 12.5 eV nine other Rydberg states converging to the 1,1-C2H2FCl+ ( 2A') first excited state were analyzed by the same way. The vibrational structure of these Rydberg states results from the excitation of one vibrational normal mode ν7 with an average value of ω7= 520±20 cm-1 which is assigned to the C-Cl stretching vibration as inferred from quantum chemical calculations. [less ▲]

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See detailIntegration of inland waterway transport in the intermodal supply chain: a taxonomy of research challenges
Caris, An; Limbourg, Sabine ULg; Macharis, Cathy et al

in Journal of Transport Geography (2014), 41

This paper identifies research opportunities which will enable the further integration of inland waterway transport in the intermodal supply chain. Intermodal transport may be interpreted as a chain of ... [more ▼]

This paper identifies research opportunities which will enable the further integration of inland waterway transport in the intermodal supply chain. Intermodal transport may be interpreted as a chain of actors who supply a transport service. Inland navigation can play a crucial role in increasing supply chain service performance. A first group of research challenges lies in the evolving relationship between transport geography and logistics activities. The next set of research challenges has the objective to encourage efficient operations in IWT: development of a system wide model for IWT, integration of operational planning systems and analysis of bundling networks. A third group of research efforts is directed towards shippers and consignees who use the intermodal transport chain to send or receive their goods: further development of models that integrate intermodal transport decisions with supply chain decisions and creation of green supply chains. A fourth cluster of research challenges concerns the problem domain of external cost calculations. Finally detailed time series data on freight transport should be collected to support these future research tracks? [less ▲]

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See detailSynthesis of protected α-alkyl lanthionine derivatives
Denoël, Thibaut; Zervosen, Astrid ULg; Lemaire, Christian ULg et al

in Tetrahedron (2014), 70(30), 4526-4533

Abstract Protected α-alkyl lanthionine derivatives were synthesized in five steps starting from a known phenyloxazoline precursor. This approach involved the synthesis of a family of substituted cyclic ... [more ▼]

Abstract Protected α-alkyl lanthionine derivatives were synthesized in five steps starting from a known phenyloxazoline precursor. This approach involved the synthesis of a family of substituted cyclic sulfamidates and their regioselective opening by nucleophilic attack with a protected cysteine. This efficient multistep strategy affords various α-alkylated lanthionine derivatives in high yields. [less ▲]

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See detailInsights into oxygen transport and net community production in sea ice from oxygen, nitrogen and argon concentrations
Zhou, Jiayun ULg; Delille, Bruno ULg; Brabant, F. et al

in Biogeosciences (2014), 11

We present the evolution of O2 standing stocks, saturation levels and concentrations in landfast sea ice, collected in Barrow (Alaska), from February to June 2009. The comparison of the standing stocks ... [more ▼]

We present the evolution of O2 standing stocks, saturation levels and concentrations in landfast sea ice, collected in Barrow (Alaska), from February to June 2009. The comparison of the standing stocks and saturation levels of O2 against those of N2 and Ar suggests that the dynamic of O2 in sea ice strongly depends on physical processes (gas incorporation and subsequent transport). We then discuss on the use of O2 / Ar and O2 / N2 to correct for the physical contribution and to determine the biological contribution (NCP) to O2 supersaturations. We conclude that O2 / Ar suits better than O2 / N2, because O2 / N2 is more sensitive due to the relative abundance of O2, N2 and Ar, and less biased when gas bubble formation and gas diffusion are maximized. We further estimate the NCP in the impermeable layers during ice growth and in the permeable layers during ice decay. Our results indicate that NCP contributed to a~release of carbon to the atmosphere in the upper ice layers, but to an uptake of carbon at sea ice bottom. Overall, seawater (rather than the atmosphere) may be the main supplier of carbon for sea ice microorganisms. [less ▲]

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See detailNormal reference ranges for echocardiography: do we really need more?
Lancellotti, Patrizio ULg

in European heart journal cardiovascular Imaging (2014), 15(3), 253-4

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See detailEffect of fuel and kiln type on the polycyclic aromatic hydrocarbon (PAH) levels in smoked shrimp, a Beninese food condiment
Kpoclou, Euloge; Anihouvi, Victor; Azokpota, Paulin et al

in Food Additives & Contaminants. Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment (2014), 31(7), 1212-1218

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See detailPatterns of tree species composition across tropical African forests
Fayolle, Adeline ULg; Swaine, Michael D.; Bastin, Jean-François ULg et al

in Journal of Biogeography (2014), online

Aim : In this study we identified large-scale variation in tree species composition across tropical African forests and determined the underlying environmental and historical factors. Location : Tropical ... [more ▼]

Aim : In this study we identified large-scale variation in tree species composition across tropical African forests and determined the underlying environmental and historical factors. Location : Tropical forests from Senegal to Mozambique. Methods : Distribution data were gathered for 1175 tree species in 455 sample sites scattered across tropical Africa, including all types of tropical forests (wet, moist, dry, and lowland to moderate elevation montane forests). The value of elevation and 19 climatic variables extracted from the BIOCLIM data set were assigned to each sample site. We determined the variation in species composition using correspondence analysis and identified the environmental correlates. We defined floristic clusters according to species composition and identified the characteristic species using indicator analysis. Results : We identified a major floristic discontinuity located at the Albertine rift that separated the dry, moist and wet forests of West and Central Africa (the entire Guineo-Congolian Region) from the upland and coastal forests of East Africa. Except for the Albertine Rift, we found no evidence to support the other proposed floristic discontinuities (Dahomey Gap etc.). We detected two main environmental gradients across tropical African forests. The rainfall gradient was strongly correlated with the variation in tree species composition in West and Central Africa. The elevation/temperature gradient highlighted the major floristic differences within East Africa and between East Africa and the Guineo-Congolian Region, the latter being most probably due to the geological disruption and associated climatic history of the East African uplift. Main conclusions : We found floristic evidence for three main biogeographical regions across the tropical African forests, and described six floristic clusters with particular environmental conditions within these regions: Coastal and Upland for East Africa, Dry and Wet-Moist for West Africa, and Moist and Wet for Central Africa. [less ▲]

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See detailAssessing the effects of spatial discretization on large-scale flow model performance and prediction uncertainty
Wildemeersch, Samuel ULg; Goderniaux, Pascal; Orban, Philippe ULg et al

in Journal of Hydrology (2014), 510

Large-scale physically-based and spatially-distributed models (>100 km2) constitute useful tools for water management since they take explicitly into account the heterogeneity and the physical processes ... [more ▼]

Large-scale physically-based and spatially-distributed models (>100 km2) constitute useful tools for water management since they take explicitly into account the heterogeneity and the physical processes occurring in the subsurface for predicting the evolution of discharge and hydraulic heads for several predictive scenarios. However, such models are characterized by lengthy execution times. Therefore, modelers often coarsen spatial discretization of large-scale physically-based and spatially-distributed models for reducing the number of unknowns and the execution times. This study investigates the influence of such a coarsening of model grid on model performance and prediction uncertainty. The improvement of model performance obtained with an automatic calibration process is also investigated. The results obtained show that coarsening spatial discretization mainly influences the simulation of discharge due to a poor representation of surface water network and a smoothing of surface slopes that prevents from simulating properly surface water-groundwater interactions and runoff processes. Parameter sensitivities are not significantly influenced by grid coarsening and calibration can compensate, to some extent, for model errors induced by grid coarsening. The results also show that coarsening spatial discretization mainly influences the uncertainty on discharge predictions. However, model prediction uncertainties on discharge only increase significantly for very coarse spatial discretizations. [less ▲]

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See detailRevisiting the Palaeolithic site of Kulbulak (Uzbekistan): First results from luminescence dating
Vandenberghe, D.A.G.; Flas, Damien ULg; De Dapper, Morgan et al

in Quaternary International (2014), 324

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See detailAssessment of Solvent Degradation within a Global Process Model of Post-Combustion CO2 Capture
Léonard, Grégoire ULg; Toye, Dominique ULg; Heyen, Georges ULg

in Computer Aided Chemical Engineering (2014), 33

Solvent degradation may be a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. However, its influence on the ... [more ▼]

Solvent degradation may be a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. However, its influence on the process operations has rarely been studied. In the present work, a kinetics model describing solvent oxidative and thermal degradation has been developed based on own experimental results for the benchmark solvent, i.e. 30 wt% monoethanolamine (MEA) in water. This model has been included into a global Aspen Plus model of the CO2 capture process. The selected process modelling approaches are described in the present work. Using the resulting simulation model, optimal operating conditions can be identified to minimize both the energy requirement and the solvent degradation in the process. This kind of process model assessing solvent degradation may contribute to the design of large-scale CO2 capture plants to consider not only the process energy penalty, but also its environmental penalty. Indeed, both aspects are relevant for the large-scale deployment of the CO2 capture technology. [less ▲]

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See detailChromera velia, Endosymbioses and the Rhodoplex Hypothesis - Plastid Evolution in Cryptophytes, Alveolates, Stramenopiles and Haptophytes (CASH Lineages)
Petersen, Jörn; Ludewig, Ann-Kathrin; Michael, Victoria et al

in Genome Biology and Evolution (2014)

The discovery of Chromera velia, a free-living photosynthetic relative of apicomplexan pathogens, has provided an unexpected opportunity to study the algal ancestry of malaria parasites. In this work we ... [more ▼]

The discovery of Chromera velia, a free-living photosynthetic relative of apicomplexan pathogens, has provided an unexpected opportunity to study the algal ancestry of malaria parasites. In this work we compared the molecular footprints of a eukaryote-to-eukaryote endosymbiosis in C. velia to their equivalents in peridinin-containing dinoflagellates (PCD) to re- evaluate recent claims in favor of a common ancestry of their plastids. To this end, we established the draft genome and a set of full-length cDNA sequences from C. velia via next- generation sequencing. We documented the presence of a single coxI gene in the mitochondrial genome, which thus represents the genetically most reduced aerobic organelle identified so far, but focused our analyses on five “lucky genes” of the Calvin cycle. These were selected because of their known support for a common origin of complex plastids from cryptophytes, alveolates (represented by PCDs), stramenopiles and haptophytes (CASH) via a single secondary endosymbiosis with a red alga. As expected, our broadly sampled phylogenies of the nuclear- encoded Calvin cycle markers support a rhodophycean origin for the complex plastid of Chromera. However, they also suggest an independent origin of apicomplexan and dinophycean (PCD) plastids via two eukaryote-to-eukaryote endosymbioses. Although at odds with the current view of a common photosynthetic ancestry for alveolates, this conclusion is nonetheless in line with the deviant plastome architecture in dinoflagellates and the morphological paradox of four versus three plastid membranes in the respective lineages. Further support for independent endosymbioses is provided by analysis of five additional markers, four of them involved in the plastid protein import machinery. Finally, we introduce the “rhodoplex hypothesis” as a convenient way to designate evolutionary scenarios where CASH plastids are ultimately the product of a single secondary endosymbiosis with a red alga, but were subsequently horizontally spread via higher-order eukaryote-to-eukaryote endosymbioses. [less ▲]

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See detailEffects of vitamin D in the elderly population : current status and perspectives
Bruyère, Olivier ULg; CAVALIER, Etienne ULg; Souberbielle, JC et al

in Archives of Public Health (2014), 72

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support ... [more ▼]

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case–control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated. [less ▲]

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See detailThe Coexistence Approach--theoretical background and practical considerations of using plant fossils for climate quantification
Utescher, T.; Bruch, A. A.; Erdei, B. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2014), 410

The Coexistence Approach was established by Mosbrugger and Utescher (1997) as a plant-based method to re- construct palaeoclimate by considering recent climatic distribution ranges of the nearest living ... [more ▼]

The Coexistence Approach was established by Mosbrugger and Utescher (1997) as a plant-based method to re- construct palaeoclimate by considering recent climatic distribution ranges of the nearest living relatives of each fossil taxon. During its existence for over more than 15 years, its basics have been tested and reviewed in comparison with other terrestrial and marine climate reconstruction techniques and climate modelling data. However, some controversies remain about its underlying data or its applicability in general. In view of these controversies this paper discusses the power and limitations of the Coexistence Approach by summarising past results and new developments. We give insights into the details and problems of each step of the application from the assignment of the fossil plant to the most suitable nearest living relative, the crucial consideration of the usefulness of specific taxa towards their climatic values and the correct interpretation of the software-based suggested palaeoclimatic intervals. Furthermore, we reflect on the fundamental data inte- grated in the Coexistence Approach by explaining different concepts and usages of plant distribution information and the advantages and disadvantages of modern climatic maps. Additionally, we elaborate on the importance of continually updating the information incorporated in the database due to new findings in e.g., (palaeo-)botany, meteorology and computer technology. Finally, for a transparent and appropriate use, we give certain guidelines for future applications and emphasize to users how to carefully consider and discuss their results. We show the Coexistence Approach to be an adaptive method capable of yielding palaeoclimatic and palaeoenvironmental information through time and space. [less ▲]

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See detailPrognosis and therapy of tumor-related versus non-tumor-related status epilepticus: a systematic review and meta-analysis.
Arik, Yunus; Leijten, Frans Ss; Seute, Tatjana et al

in BMC neurology (2014), 14

BACKGROUND: Status epilepticus (SE) is a medical emergency with high mortality rates. Of all SE's, 7% are caused by a brain tumor. Clinical guidelines on the management of SE do not make a distinction ... [more ▼]

BACKGROUND: Status epilepticus (SE) is a medical emergency with high mortality rates. Of all SE's, 7% are caused by a brain tumor. Clinical guidelines on the management of SE do not make a distinction between tumor-related SE and SE due to other causes. However, pathophysiological research points towards specific mechanisms of epilepsy in brain tumors. We investigated whether clinical features support a distinct profile of tumor-related SE by looking at measures of severity and response to treatment. METHODS: Systematic review of the literature and meta-analysis of studies on adult SE that report separate data for tumor-related SE and non-tumor-related SE on the following outcomes: short-term mortality, long-term morbidity, duration of SE, and efficacy of anticonvulsant intervention. RESULTS: Fourteen studies on outcome of SE were included. Tumor-related SE was associated with higher mortality than non-tumor-related SE (17.2% versus 11.2%, RR 1.53, 95%-CI 1.24-1.90). After exclusion of patients with hypoxic-ischemic encephalopathy (a group with a known poor prognosis) from the non-tumor-group, the difference in mortality increased (17.2% versus 6.6%; RR 2.78, 95%-CI 2.21 - 3.47). Regarding long-term morbidity and duration of SE there were insufficient data. We did not find studies that systematically compared effects of therapy for SE between tumor- and non-tumor-related SE. CONCLUSIONS: Based on - mostly retrospective - available studies, short-term mortality seems higher in tumor-related SE than in SE due to other causes. Further studies on the outcome and efficacy of different therapeutic regimens in tumor-related SE are needed, to clarify whether tumor-related SE should be regarded as a distinct clinical entity. [less ▲]

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See detailAs Above, so Below: Narrative Salience and Side Effects of National Innovation Systems
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Critical Policy Studies (2014), accepté à publication

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See detailAn efficient flamelet-based combustion model for compressible flows
Saghafian, Amirreza; Terrapon, Vincent ULg; Pitsch, Heinz

in Combustion and Flame (2014)

A combustion model based on a flamelet/progress variable approach for high-speed flows is introduced. In the proposed formulation, the temperature is computed from the transported total energy and ... [more ▼]

A combustion model based on a flamelet/progress variable approach for high-speed flows is introduced. In the proposed formulation, the temperature is computed from the transported total energy and tabulated species mass fractions. Only three additional scalar equations need to be solved for the combustion model. Additionally, a flamelet library is used that is computed in a pre-processing step. This approach is very efficient and allows for the use of complex chemical mechanisms. An approximation is also introduced to eliminate costly iterative steps during the temperature calculation. To better account for compressibility effects, the chemical source term of the progress variable is rescaled with the density and temperature. The compressibility corrections are analyzed in an a priori study. The model is also tested in both Reynolds-averaged Navier–Stokes (RANS) and large-eddy simulation (LES) computations of a hydrogen jet in a supersonic transverse flow. Comparison with experimental measurements shows good agreement, particularly for the LES case. It is found that the disagreement between RANS results and experimental data is mostly due to the mixing model deficiencies and the presumed probability density functions used in the RANS formulation. A sensitivity study of the proposed model shows the importance of the compressibility corrections especially for the source term of the progress variable. [less ▲]

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See detailFaites vos jeux, rien ne va plus ... la peau a l'age de la retraite, aujourd'hui et demain.
Pierard, Gérald ULg; Lesuisse, M.; Saint-Leger, D. et al

in Revue medicale de Liege (2014), 69(5-6), 366-71

Senescence of people represents a global expression of obsolescence of their organs, tissues, cells and constitutive molecules. Skin, similarly to any other organ, is ageing in particular ways. Over the ... [more ▼]

Senescence of people represents a global expression of obsolescence of their organs, tissues, cells and constitutive molecules. Skin, similarly to any other organ, is ageing in particular ways. Over the past century, the time effects on skin have been expressed differently. Skin of any individual presently engaged in the Third Age looks different from that of his/her line ancestral. What is the expected future? The Third Age population is expanding and skin problems call for a variety of management procedures. Prevention of the diverse types of skin ageing has made tremendous progresses particularly in the field of preventive and corrective dermocosmetology. The future should further speed up such trends. [less ▲]

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See detailDirect evidence for gray seal (Halichoerus grypus) predation and scavenging on harbor porpoises (Phocoena phocoena)
Bouveroux, T.; Kiszka, J.; Heithaus, R. et al

in Marine Mammal Science (2014)

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See detailValorisation des résidus de bois issus de l'exploitation artisanale des forêts communautaires au Cameroun : cas de la forêt communautaire de Mambioko (Gic CRCV)
Malnoury, Gauthier; Zoyiem Ngouanet, Edmond; Julve Larrubia, Cecilia et al

in Tropicultura (2014), 32(2), 90-94

L’exploitation artisanale du bois des forêts communautaires au Cameroun génère une quantité importante de résidus abandonnés au niveau des sites d’exploitation. Ces pièces de bois pourraient être ... [more ▼]

L’exploitation artisanale du bois des forêts communautaires au Cameroun génère une quantité importante de résidus abandonnés au niveau des sites d’exploitation. Ces pièces de bois pourraient être valorisées en produits commercialisables de manière à améliorer les revenus de la communauté. Cette étude a permis une première estimation de ce volume et présente différentes pistes de valorisation adaptées à la communauté de Mambioko. Cette étude de cas s’adresse à tous les acteurs de la foresterie communautaire au Cameroun et vise une valorisation rationnelle de la matière ligneuse dans un but de développement rural. [less ▲]

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See detailType I error inflation in DIF identification with Mantel-Haenszel: an explanation and a solution
Magis, David ULg; De Boeck, Paul

in Educational & Psychological Measurement (2014), 74

It is known that sum score-based methods for the identification of differential item functioning (DIF), such as the Mantel-Haenszel (MH) approach, can be affected by Type I error inflation in the absence ... [more ▼]

It is known that sum score-based methods for the identification of differential item functioning (DIF), such as the Mantel-Haenszel (MH) approach, can be affected by Type I error inflation in the absence of any DIF effect. This may happen when the items differ in discrimination and when there is item impact. On the other hand, outlier DIF methods have been developed that are robust against this Type I error inflation, while they are still based on the MH DIF statistic. The present paper gives an explanation for why the common MH method is indeed vulnerable to the inflation effect while the outlier DIF versions are not. In a simulation study we were able to produce the Type I error inflation by inducing item impact and item differences in discrimination. At the same time and in parallel with the Type I error inflation the dispersion of the DIF statistic across items was increased. As expected, the outlier DIF methods did not seem sensitive to impact and differences in item discrimination. [less ▲]

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See detailCompte rendu de Han BALTUSSEN, Michael ATKINSON, Michael SHARE, Ian MUELLER (trad.), Simplicius: On Aristotle Physics 1.5-9
Gavray, Marc-Antoine ULg

in International Journal of the Platonic Tradition (2014), 8(1), 115-117

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See detailLa modélisation à l’aide du modèle SWAT des flux hydriques et du transport en suspension sur le bassin versant de la vallée de l’oued EL-Hachem
Tadrist, Nassima ULg; Debauche, Olivier ULg

in Revue des Régions Arides (2014)

Dans le Maghreb, les barrages souffrent régulièrement d’un envasement excessif lié aux problèmes d’érosion présent dans les impluviums situés en amont des barrages. Les origines de cette érosion sont ... [more ▼]

Dans le Maghreb, les barrages souffrent régulièrement d’un envasement excessif lié aux problèmes d’érosion présent dans les impluviums situés en amont des barrages. Les origines de cette érosion sont multiples : aménagement du territoire, déforestation, affectation des terres,… L’hydrologie couplée aux systèmes d’informations géographiques permet à l’aide de modèles distribués et physiquement basés de prédire l’évolution de l’envasement des barrages. L’application de ces modèles en Algérie permettra à terme, de prédire l’impact d’aménagement anti érosifs, de schémas d’aménagement du territoire sur l’envasement des barrages en estimant précisément la quantité de sédiments produit par l’érosion par ruissellement ainsi que le taux de remplissage. Une méthodologie basée sur les données cartographiques (modèle numérique de terrain, carte pédologie, carte géologie et la cartographie d’occupation du sol) ainsi que les données météorologiques journalières (température, humidité relative, vitesse du vent, radiation solaire) est en cours d’élaboration et de test sur le barrage de Bourkourdane. Cette méthodologie utilise le modèles SWAT Le modèle SWAT est utilisé pour prédire la quantité de sédiment s’accumulant dans le barrage, les flux hydriques débit entrants, sortants, ainsi que les volumes d’eau et de sédiments stockés dans le barrage. Une gestion adéquates des lâchers, couplée à une meilleure gestion de l’érosion en amont du barrage permettra d’allonger la durée de vie des barrages Algériens. Plus particulièrement pour le barrage de Boukourdane, une amélioration de la gestion des lâchers est primordiale pour améliorer la recharge de la nappe, lutter contre l’intrusion des eaux marines, et prévenir l’accumulation des particules fines qui réduisent la perméabilité du sol. [less ▲]

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See detailEditorial
Bourgeois, Marc ULg

in Revue de Fiscalité Régionale et Locale (2014), Liv. 1

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See detailInfluence des représentations sociales de l’environnement sur l’adoption des pratiques durables de production. Une contribution à partir du système de production de coton biologique au Bénin
Assogba, Sonagnon Claude-Gervais ULg; Tossou, Cocou Rigobert; Lebailly, Philippe ULg

in Journal of Oriental and African Studies (2014), 23

Le présent article est une contribution à l’analyse des facteurs qui déterminent le comportement des producteurs dans l’odoption des pratiques durables de production de coton au Bénin. Il s’appuie sur une ... [more ▼]

Le présent article est une contribution à l’analyse des facteurs qui déterminent le comportement des producteurs dans l’odoption des pratiques durables de production de coton au Bénin. Il s’appuie sur une recherche menée auprès des biocotonculteurs de la commune de Kandi dans le bassin cotonnier du Nord-Bénin. L’objectif visé est de caractériser les représentations sociales des producteurs de l’environnement et de mieux cerner en quoi elles déterminent leur comportement dans l’appropriation du système de production de coton biologique. Les données ont été collectées auprès d’un échantillon de 188 producteurs sélectionnés à partir d’une typologie à dires d’acteurs, basée sur les critères endogènes de prospérité. L’approche structurale des représentations sociales et le test d’indépendance de chi 2 ont été utilisés à cet effet. Il ressort des résultats et analyses que les producteurs de coton biologique ont une vision anthropocentrique et utilitariste de l’environnement qu’ils perçoivent comme un réservoir pourvoyeur des ressources nécessaires pour leur survie. L’adhésion des producteurs au programme de production de coton biologique est sous-tendue par des motivations d’abord économiques (40%) puis environnementales (18%) et sociales (11%). Il est apparu que le type de comportement adopté par le producteur dans la mise en œuvre des pratiques de production biologique est davantage lié aux facteurs qui motivent son adhésion. Aussi, avons-nous montré que les producteurs qui respectent mieux les exigences du système de production biologique sont ceux dont l’adhésion est principalement mue par des considérations environnementales. [less ▲]

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See detailAge Estimation from Faces and Voices: A Review
Moyse, Evelyne ULg

in Psychologica Belgica (2014), 54(3), 255-265

Age estimation is a skill that we use in everyday life and that is also important in more specific settings such as police testimony. Researchers investigated age estimation either from faces or voices ... [more ▼]

Age estimation is a skill that we use in everyday life and that is also important in more specific settings such as police testimony. Researchers investigated age estimation either from faces or voices but a direct comparison between voices and faces was rather infrequently performed. This paper reviews the literature on age estimation from faces and voices and highlights some similarities and differences. Data from a series of experiments suggest that age estimation from faces and voices can be fairly accurate, but in some cases, a superiority of faces is observed. The age of participants and stimuli both seem to affect age estimation from faces and voices in the same way: (1) age estimation is more accurate for young stimuli than for older stimuli, (2) younger participants are more accurate than older participants irrespective of the age of stimuli, and (3) an own-age bias affects age estimation. By contrast, the influence of ethnicity and gender has been less documented. Available data support that ethnicity influence age estimation from faces but not clearly age estimation from voices. Regarding the effect of stimuli gender, results were opposite: in age estimation from faces, an advantage for male faces was reported whereas in age estimation from voices, the advantage is in favor of female voices. [less ▲]

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See detailSpatial Planning as a driver of change in mobility and residential energy consumption
Dujardin, Sébastien; Marique, Anne-Françoise ULg; Teller, Jacques ULg

in Energy & Buildings (2014), 68

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning ... [more ▼]

This paper analyses the impact of territorial structures upon energy consumption in the Walloon Region (Belgium). The rationale for this research is to consider the long-term influence of spatial planning decisions upon energy consumption in both residential building stock and home-to-work commuting. The analysis has been conducted on a regional scale (16,844 km2) and includes urban, peri-urban and rural settlements. Those settlements that perform well in mobility also appear to perform well in terms of building energy consumption. Even though this is not generally the case, it further reveals that some rural settlements characterized by low density show good performance in terms of energy efficiency. This permits a much more progressive approach in terms of spatial planning, whereby compact cities may be viewed as part of the solution, albeit not the whole solution. [less ▲]

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See detailIron loss calculation in steel laminations at high frequencies
Henrotte, François; Steentjes, Simon; Hameyer, Kay et al

in IEEE Transactions on Magnetics (2014), 50(2), 333-336

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See detailMulti-scale modeling of mycosubtilin lipopeptides at the air/water interface: structure and optical second harmonic generation
Loison, Claire; Nasir, Mehmet Nail ULg; Benichou, Emmanuel et al

in Physical Chemistry Chemical Physics [=PCCP] (2014), 16

Monolayers of the lipopeptide mycosubtilin are studied at the air/water interface. Their structure is investigated using molecular dynamics simulations. All-atom models suggest that the lipopeptide is ... [more ▼]

Monolayers of the lipopeptide mycosubtilin are studied at the air/water interface. Their structure is investigated using molecular dynamics simulations. All-atom models suggest that the lipopeptide is flexible and aggregates at the interface. To achieve simulation times of several microseconds, a coarse-grained (CG) model based on the MARTINI force field was also used. These CG simulations describe the formation of half-micelles at the interface for surface densities up to 1 lipopeptide per nm2. In these aggregates, the tyrosine side chain orientation is found to be constrained: on average, its main axis, as defined along the C–OH bond, aligns along the interface normal and points towards the air side. The origin of the optical second harmonic generation (SHG) from mycosubtilin monolayers at the air/water interface is also investigated. The molecular hyperpolarizability of the lipopeptide is obtained from quantum chemistry calculations. The tyrosine side chain contribution to the hyperpolarizability is found to be dominant. The orientation distribution of tyrosine, associated with a dominant hyperpolarizability component along the C–OH bond of the tyrosine, yields a ratio of the susceptibility elements χ(2)ZZZ/χ(2)ZXX consistent with the experimental measurements recently reported by M. N. Nasir et al. [Phys. Chem. Chem. Phys., 2013, 15, 19919]. [less ▲]

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See detailThe role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women : A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Rizzoli, R; Stevenson, JC; Bauer, JM et al

in Maturitas (2014), 79

From 50 years of age, postmenopausal women are at an increased risk of developing sarcopenia and osteoporosis as a result of deterioration of musculoskeletal health. Both disorders increase the risk of ... [more ▼]

From 50 years of age, postmenopausal women are at an increased risk of developing sarcopenia and osteoporosis as a result of deterioration of musculoskeletal health. Both disorders increase the risk of falls and fractures. The risk of developing sarcopenia and osteoporosis may be attenuated through healthy lifestyle changes, which include adequate dietary protein, calcium and vitamin D intakes, and regular physical activity/exercise, besides hormone replacement therapy when appropriate. Protein intake and physical activity are the main anabolic stimuli for muscle protein synthesis. Exercise training leads to increased muscle mass and strength, and the combination of optimal protein intake and exercise produces a greater degree of muscle protein accretion than either intervention alone. Similarly, adequate dietary protein intake and resistance exercise are important contributors to the maintenance of bone strength. Vitamin D helps to maintain muscle mass and strength as well as bone health. These findings suggest that healthy lifestyle measures in women aged >50 years are essential to allow healthy ageing. The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) recommends optimal dietary protein intake of 1.0–1.2 g/kg body weight/d with at least 20–25 g of high-quality protein at each main meal, with adequate vitamin D intake at 800 IU/d to maintain serum 25-hydroxyvitamin D levels >50 nmol/L as well as calcium intake of 1000 mg/d, alongside regular physical activity/exercise 3–5 times/week combined with protein intake in close proximity to exercise, in postmenopausal women for prevention of age-related deterioration of musculoskeletal health. [less ▲]

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See detailInvolvement of Nitric Oxide and ATP-Sensitive Potassium Channels in the Peripheral Antinoceptive Action of a Tramadol–Dexketoprofen Combination in the Formalin Test
Isiordia-Espinoza, Mario A.; Pozos-Guillén, Amaury; Pérez-Urizar, José et al

in Drug Development Research (2014)

Systemic coadministration of tramadol and dexketoprofen can produce antinociceptive synergism in animals. There has been only limited evaluation of this drug combination in the peripheral nervous system ... [more ▼]

Systemic coadministration of tramadol and dexketoprofen can produce antinociceptive synergism in animals. There has been only limited evaluation of this drug combination in the peripheral nervous system in terms of the antinociceptive interaction and its mechanisms. The aim of the present study was to evaluate the peripheral antinociceptive interaction between tramadol and dexketoprofen in the formalin test and the involvement of the nitric oxide (NO)–cyclic guanosine monophosphate pathway and ATP-sensitive K+ channels. Different doses of tramadol or exketoprofen were administered locally to the formalin-injured mouse paw and the antinociceptive effect evaluated. ED50 values were calculated for both drugs alone and in combination. Coadministration of tramadol and dexketoprofen produced an antinociceptive synergistic interaction during the second phase of the formalin test. Pretreatment with NO antagonists, including l-NG-nitroarginine methyl ester and 1H-[1,2,4]-oxadiazolo-[4,3-a]-quinoxalin-1- one, or the ATP-sensitive K+ channel antagonist glibenclamide reversed the antinociceptive synergistic effect of the tramadol–dexketoprofen combination, suggesting that NO and ATP-sensitive K+ channels were involved. [less ▲]

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See detailPhotic memory for executive brain responses
Chellappa*, Sarah Laxhmi ULg; Ly*, Julien ULg; Meyer, Christelle ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2014), Epub ahead of print

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See detailPrix prédateurs : La Cour d’appel de Paris saisit l’Autorité de la Concurrence d’une demande d’avis pour apprécier le caractère prédateur d’un prix nul
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2014), 1

CA Paris, 20 novembre 2013, Google France et Google c/ Bottin Cartographe

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See detailWhat is the current statut of chondroitin sulfate and glucosamine in the treatment of knee osteoarthritis?
Henrotin, Yves ULg; Marty, Marc; Mobasheri, Ali

in Maturitas (2014), 78

Chondroitin sulfate and glucosamine sulfate exert beneficial effects on the metabolism of in vitro models of cells derived from synovial joints: chondrocytes, synoviocytes and cells from subchondral bone ... [more ▼]

Chondroitin sulfate and glucosamine sulfate exert beneficial effects on the metabolism of in vitro models of cells derived from synovial joints: chondrocytes, synoviocytes and cells from subchondral bone, all of which are involved in osteoarthritis (OA). They increase type II collagen and proteoglycan synthesis in human articular chondrocytes and are able to reduce the production of some pro-inflammatory mediators and proteases, to reduce the cellular death process, and improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Clinical trials have reported a beneficial effect of chondroitin sulfate and glucosamine sulfate on pain and function. The structure-modifying effects of these compounds have been reported and analyzed in recent meta-analyses. The results for knee OA demonstrate a small but significant reduction in the rate of joint space narrowing. Chondroitin sulfate and glucosamine sulphate are recommended by several guidelines from international societies for the management of knee and hip OA, while others do not recommend these products or recommend only under condition. This comprehensive review clarifies the role of these compounds in the therapeutic arsenal for patients with knee OA [less ▲]

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See detailThe effects of stress on singing voice accuracy
Larrouy, Pauline ULg; Morsomme, Dominique ULg

in Journal of Voice (2014), 28(1), 52-58

Objective: The quality of a music performance can be lessened or enhanced if the performer experiences stressful conditions. In addition, the quality of a sung performance requires control of the ... [more ▼]

Objective: The quality of a music performance can be lessened or enhanced if the performer experiences stressful conditions. In addition, the quality of a sung performance requires control of the fundamental frequency of the voice, which is particularly sensitive to stress. The present study aimed to clarify the effects of stress on singing voice accuracy. Methods: Thirty-one music students were recorded in a stressful condition (i.e., a music examination) and a non-stressful condition. Two groups were defined according to the challenge level of the music examination (first and second music levels). Measurements were made by self-reported state anxiety (CSAI-2R questionnaire) and by observing heart rate activity (electrocardiogram) during each performance. In addition, the vocal accuracy of the sung performances was objectively analyzed. Results: As expected, state anxiety and heart rate were significantly higher on the day of the music examination than in the non-stressful condition for all the music students. However, the effect of stress was positive for the first-year students but negative for the second-year students, for whom the music examination was particularly challenging. In addition, highly significant correlations were found between the intensity of cognitive symptoms and the vocal accuracy criteria. Discussion: This study highlights the contrasting effects of stress on singing voice accuracy but also the need to consider the challenge level and perception of the symptoms in experimental and pedagogical settings. [less ▲]

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See detailChemical and biological evaluation of the nutritive value of Algerian green seaweed Ulva lactuca using in vitro gas production technique fior ruminant animals
Zitouni, Hind; Arhab, Rabah; Boudry, Christelle ULg et al

in International Journal of Advanced Research (2014), 2(4), 916-925

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to ... [more ▼]

This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to vetch-oat hay (control), using in vitro gas production technique. Seaweed and control were incubated with rumen liquor taken from fistulated and non lactating cows. Gas production was recorded at: 2, 4, 6, 8, 12, 24, 48 and 72h. The in vitro rumen fermentation parameters were measured after 24h and 72h of fermentation. Proteins degradability was investigated by the enzymatic technique using a protease extracted from Streptomyces griseus. The results showed a wide variation between the chemical components of seaweed and conventional fodder used as control. The main constituents in Ulva lactuca were ashes (39.1% DM), fibers (22.8 % DM) and proteins (15.3% DM). The gas production profile of seaweed during 72h of incubation showed a slow and low gas production. Cumulative gas production obtained after 24h for seaweed (42 ml/g OM) was significantly lower than control (128.4 ml/g OM) (P<0.001). pH, ammonia, volatile fatty acids (VFAs), apparent digestibility of dry matter (DDM), organic matter digestibility (OMD) and metabolizable energy (ME) were significantly different between seaweed and vetch-oat hay (6.86, 290.1 mg/ml, 1.25 mmol/g DM, 38.3%, 29.2%, 3.81MJ/Kg DM respectively for seaweed). Protein degradability measurement indicates the weak hydrolysis of seaweed crude protein which is beneficial for ruminants. This study showed that the use of Ulva lactuca as non conventional feed in ruminant nutrition can be considered under certain conditions. [less ▲]

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See detailSimultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry
Dewalque, Lucas ULg; PIRARD, Catherine ULg; DUBOIS, Nathalie ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2014), 949-950

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to ... [more ▼]

Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to some hormonal diseases. Numerous large-scale biomonitoring studies have detected the biomarkers of these compounds in more than 75% of the general population. To assess the exposure to these chemicals, we developed an analytical method based on a Solid Phase Extraction (SPE) prior to ultra high pressure liquid chromatographytandem mass spectrometry (UPLC-MS/MS) for the simultaneous measurement of seven phthalate metabolites (monobenzyl phthalate, mono-n-butyl phthalate, mono-iso-butyl phthalate, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2- ethyl-5-oxohexyl phthalate, monoethyl phthalate), four parabens (methyl paraben, ethyl paraben, n-propyl paraben, n-butyl parabens) and benzophenone-3 in human urine. The distinction between unconjugated, glucuro- and sulfoconjugated forms was achieved using different enzymatic hydrolyses. The whole procedure was validated according to the total error approach, and was demonstrated to be linear (regression coefficient ranging from 0.987 to 0.998) and accurate (inter and intra assay precision <17.71%, relative bias <5.87%) in the dosing range of concentrations. The limits of quantification (LOQs) obtained ranged between 0.30 and 1.23 ng/ml depending on the analyte. The reliability of the method was proven in passing successfully the German External Quality Assessment Scheme (G-EQUAS). Moreover, the urine from 25 volunteers were analyzed for the determination of glucuro-, sulfo- and free species separately. Phthalate metabolites, parabens and benzophenone-3 were positively detected in almost all urine samples, with detection rates ranging from 40 to 100%. Levels measured ranged from <LOQ to 2207 ng/ml varying widely depending on the compound and the individual. In our small participating population, most of the phthalate metabolites were excreted predominately as glucuroconjugated forms while parabens and benzophenone-3 were detected as glucuro- and sulfoconjugated species in variable proportions according to the target compound. [less ▲]

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See detailQuel universalisme des droits de l'homme?
Delruelle, Edouard ULg

in Revue Trimestrielle des Droits de l'Homme [= RTDH] (2014), 98

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See detailReduced chaos expansions with random coefficients in reduced-dimensional stochastic modeling of coupled problems
Arnst, Maarten ULg; Ghanem, Roger; Phipps, Eric et al

in International Journal for Numerical Methods in Engineering (2014), 97

We address the curse of dimensionality in methods for solving stochastic coupled problems with an emphasis on stochastic expansion methods such as those involving polynomial chaos expansions. The proposed ... [more ▼]

We address the curse of dimensionality in methods for solving stochastic coupled problems with an emphasis on stochastic expansion methods such as those involving polynomial chaos expansions. The proposed method entails a partitioned iterative solution algorithm that relies on a reduced-dimensional representation of information exchanged between subproblems to allow each subproblem to be solved within its own stochastic dimension while interacting with a reduced projection of the other subproblems. The proposed method extends previous work by the authors by introducing a reduced chaos expansion with random coefficients. The representation of the exchanged information by using this reduced chaos expansion with random coefficients enables an expeditious construction of doubly stochastic polynomial chaos expansions that separate the effect of uncertainty local to a subproblem from the effect of statistically independent uncertainty coming from other subproblems through the coupling. After laying out the theoretical framework, we apply the proposed method to a multiphysics problem from nuclear engineering. [less ▲]

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See detailBook Review: Handbook of research methods on social entrepreneurship
Dufays, Frédéric ULg

in International Small Business Journal (2014), 32(4), 471-475

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See detailFunctionalization of carbon xerogels for the preparation of palladium supported catalysts applied in sugar transformations
Mager, Nathalie; Meyer, Nathalie; Léonard, Alexandre ULg et al

in Applied Catalysis B : Environmental (2014), 148-149

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See detailLe renoncement au désir de maternité comme issue possible d’une conflictualité intrapsychique
Delli Gatti, Tamara ULg; Naziri, Despina ULg

in Dialogue : Recherches Cliniques et Sociologiques sur le Couple et la Famille (2014), 204

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See detailMesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et al

in Nephrology Dialysis Transplantation (2014)

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]

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See detailA patient-specific airway branching model for mechanically ventilated patients.
Damanhuri, Nor Salwa; Docherty, Paul D.; Chiew, Yeong Shiong et al

in Computational and mathematical methods in medicine (2014), 2014

Background. Respiratory mechanics models have the potential to guide mechanical ventilation. Airway branching models (ABMs) were developed from classical fluid mechanics models but do not provide accurate ... [more ▼]

Background. Respiratory mechanics models have the potential to guide mechanical ventilation. Airway branching models (ABMs) were developed from classical fluid mechanics models but do not provide accurate models of in vivo behaviour. Hence, the ABM was improved to include patient-specific parameters and better model observed behaviour (ABMps). Methods. The airway pressure drop of the ABMps was compared with the well-accepted dynostatic algorithm (DSA) in patients diagnosed with acute respiratory distress syndrome (ARDS). A scaling factor (alpha) was used to equate the area under the pressure curve (AUC) from the ABMps to the AUC of the DSA and was linked to patient state. Results. The ABMps recorded a median alpha value of 0.58 (IQR: 0.54-0.63; range: 0.45-0.66) for these ARDS patients. Significantly lower alpha values were found for individuals with chronic obstructive pulmonary disease (P < 0.001). Conclusion. The ABMps model allows the estimation of airway pressure drop at each bronchial generation with patient-specific physiological measurements and can be generated from data measured at the bedside. The distribution of patient-specific alpha values indicates that the overall ABM can be readily improved to better match observed data and capture patient condition. [less ▲]

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See detailLower Carboniferous Rugose corals from the Arabian Plate: an insight from the Hakkari area (SE Turkey)
Denayer, Julien ULg; Hoşgör

in Journal of Asian Earth Sciences (2014), 79(1), 345-357

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See detailHigh Prevalence of Abdominal Aortic Aneurysm in Patients with Three-vessel Coronary Artery Disease.
Durieux, R.; VAN DAMME, Hendrik ULg; Labropoulos, N. et al

in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2014)

OBJECTIVES: Currently, the prevalence of abdominal aortic aneurysm (AAA) in patients with coronary artery disease (CAD) and the correlation between CAD severity and AAA prevalence are not clearly known ... [more ▼]

OBJECTIVES: Currently, the prevalence of abdominal aortic aneurysm (AAA) in patients with coronary artery disease (CAD) and the correlation between CAD severity and AAA prevalence are not clearly known. We conducted a prospective study to determine the prevalence of AAA in patients undergoing coronary angiography and to determine the risk factors and a coronary profile associated with AAA. METHODS: Over an 18-month period, abdominal aortic ultrasound was performed on 1,000 patients undergoing coronary angiography for suspected or known CAD, or prior to valve surgery. Clinical characteristics and coronary profile were collected from the patients. RESULTS: The overall number of previously repaired, already diagnosed, and new cases of AAA in the study population was 42, yielding a prevalence of 4.2%. Among the patients with newly detected AAAs, only two had an AAA diameter of >54 mm and were therefore treated surgically. In men aged >/=65 years, the prevalence reached 8.6%, while in men with three-vessel CAD it was 14.4%. Multivariate analysis showed that age >/=65 years (p = .003), male gender (p = .003), family history of AAA (p = .01), current smoking (p = .002), and three-vessel CAD (p < .001) were significantly associated with a higher prevalence of AAA. CONCLUSION: The prevalence of AAA was high in men aged >/=65 years and in those with three-vessel CAD regardless of age. While our findings do not prove the cost-effectiveness of screening for AAA in these high risk patients, they do support the usefulness of a quick ultrasound examination of the abdominal aorta during routine transthoracic echocardiography in such patients. [less ▲]

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See detailHeart Valve Clinic: Rationale and Organization.
Lancellotti, Patrizio ULg; Rosenhek, Raphael; Pibarot, Philippe

in The Canadian journal of cardiology (2014)

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The ... [more ▼]

With an increasing prevalence of patients with valvular heart disease (VHD), a dedicated management approach delivered in a well-defined structure, namely, the heart valve clinic (HVC), is warranted. The HVC is made up of a multidisciplinary team with high expertise in the diagnosis, management, treatment, and surveillance of patients with VHD. The aim of the HVC is to provide the highest quality of care to patients with VHD to improve the level of adherence to current evidence and guidelines, quality of life, and short- and long-term outcomes. The HVC also provides help in (1) informing and educating patients to motivate them to take their prescribed medications and look out for signs indicating a worsening of their disease, (2) organizing meetings for updates in knowledge for modern management of patients with VHD, and (3) disseminating protocols of contemporary and good practice in VHD. [less ▲]

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See detailPatterns in national policies for support of low achievers in reading across Europe
Motiejunaite, Akvile; Noorani, Sogol; Monseur, Christian ULg

in British Educational Research Journal (2014)

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See detailFeruloylbenzotriazole and Weinreb Amide as Bioinspired Building Blocks: A Reactivity Study towards O-, N-, S-, and C-Nucleophiles
Roman, Bart; Monbaliu, Jean-Christophe ULg; De Coen, Laurens et al

in European Journal of Organic Chemistry (2014)

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See detailComparison of Sensory Characteristics of Green Tea Produced in Thai Nguyen and Phu Tho Province, Vietnam
Dang, Thi Minh Luyen ULg; Ha Duyen, Tu; Lebailly, Philippe ULg et al

in Journal of Food Science and Engineering (2014), 4(2/February 2014 (Serial Number 31)), 104-114

Green tea is a popular product with a high consumption in Vietnam. Moreover, green tea produced in Tan Cuong commune, Thai Nguyen province, has long been recognized for its superior quality to those ... [more ▼]

Green tea is a popular product with a high consumption in Vietnam. Moreover, green tea produced in Tan Cuong commune, Thai Nguyen province, has long been recognized for its superior quality to those coming from other regions of the country. This study aims at comparing the tea from Thai Nguyen and Phu Tho and finding out if the difference can be identified through sensory analysis. Two products picked from Tan Cuong, Thai Nguyen province, and two others from Phu Ho district, Phu Tho province were evaluated by a trained panel of 12 judges (11 women and 1 man). The sensory evaluation of the dry tea (11 descriptors) was carried out separately from the brewed tea (21 descriptors) and brewed leaf (five descriptors) using an unstructured intensity scale (10 cm). Statistic analyses have shown differences between regions in all three groups of attributes: dry leaf, liquor and brewed leaf. [less ▲]

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See detailUnusual occurrence of cocoons in population of the saddle gall midge, Haplodiplosis marginata (Diptera: Cecidomyiidae), in Belgium
Censier, Florence ULg; Chavalle, Sandrine; Skuhravá, Marcela et al

in Journal of Insect Science [=JIS] (2014)

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), is a phytophagous species that develops in saddle-shaped galls on stems of wheat Triticum vulgare, barley Hordeum ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), is a phytophagous species that develops in saddle-shaped galls on stems of wheat Triticum vulgare, barley Hordeum sativum, rye Secale cereale and some other species of Poaceae. Only one generation develops per year. Full-grown larvae leave galls, drop onto the soil where they remain up to the springtime of the following year. Larvae do not usually spin cocoons. However, formation of cocoons by larvae was observed in populations developing in western Europe: in England in 1954, in the Netherlands in the 1960s and in Belgium in 2011. On the basis of our analysis, a part of the larval population forms cocoons as protection against unfavorable weather conditions, especially drought. [less ▲]

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See detailCan faecal markers detect a short term reduction in forage intake by cattle?
Benvenutti, Marcelo A.; Coates, David B.; Bindelle, Jérôme ULg et al

in Animal Feed Science & Technology (2014), 194

Detection of a reduction in forage intake is particularly relevant in grazing animals due to its negative effect on animal performance. Estimations of intake reduction using faecal markers can be ... [more ▼]

Detection of a reduction in forage intake is particularly relevant in grazing animals due to its negative effect on animal performance. Estimations of intake reduction using faecal markers can be inaccurate due to the time delay between a change in forage intake and the subsequent change in faecal output. This delay may vary depending on forage quality and marker type. A pen study was conducted for 29 days to test the efficacy of liquid (PEG = polyethylene glycol) and solid (alkanes and CrCl3 = chromium chloride) phase faecal markers to detect a reduction in intake by steers of diets that varied in forage quality. Ten Brahman cross steers (296 ± 16 kg) were allocated equally to diets of leafy, high quality buffel grass (Cenchrus ciliaris) hay and stemmy, low quality buffel grass hay. Hay was offered ad libitum from day 1 to 7, at 90% of voluntary intake from day 8 to 14 and then reduced by 8% each day from day 15 to 24. On day 5 each steer was dosed with two slow release alkane capsules; also, steers received a single daily dose of PEG and CrCl3 at 09:00 on days 5 to 24. Actual and marker derived estimates of forage intake over days 10 to 22 were assessed by repeated-measures analysis of variance. Overall marker recovery rates were satisfactory (0.92 to 1.03) and there was a significant (P < 0.001) progressive decrease in daily recovery rate over time for all markers and diets. Actual and marker-determined forage intake declined over the course of the experiment for both leafy and stemmy hay diets (P < 0.001) for all three markers. There was a lag of 3 to 5 days to detect a significant reduction in estimated intake by steers using markers. The lag period was similar for both liquid and solid phase markers. Results of this experiment indicated that decreases in forage intake by cattle could be detected using indigestible faecal markers, albeit in association with (i) progressively larger reductions in actual forage intake, and (ii) a time lag of 3 to 5 days between the decrease in actual intake and its statistical detection using faecal markers. [less ▲]

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See detailL'économie rhétorique du Résumé
Provenzano, François ULg

in Janus. Quaderni del circolo glossematico (2014), 13

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See detailLes lipopeptides d’origine microbienne, des agents de biocontrôle aux multiples facettes
Jacques, P.; Deravel, J.; Coutte, F. et al

in Phytoma (2014), 672

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See detailRaising the Threshold, Fighting Fragmentation? Mechanical and Psychological Effects of the Legal Electoral Threshold in Belgium
Reuchamps, Min; Onclin, François ULg; Caluwaerts, Didier et al

in West European Politics (2014), 37(5), 1087-1107

Many proportional representation systems are characterised by a legal electoral threshold. Such a threshold reserves the allocation of seats for those parties that reach a minimum share of the votes. In ... [more ▼]

Many proportional representation systems are characterised by a legal electoral threshold. Such a threshold reserves the allocation of seats for those parties that reach a minimum share of the votes. In order to fight fragmentation, a 5 per cent threshold has been introduced for both federal and regional elections in Belgium. This article seeks to explore the mechanical and psychological effects of this legal threshold after five elections. It is shown that the threshold has had limited mechanical and psychological effects on voters but some psychological effects on party elites. Moreover, while in the short term the average number of lists dropped and several pre-electoral coalitions formed, in the longer term the legal threshold has not prevented further fragmentation. [less ▲]

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See detailRediscovery of the forgotten de Ryckholt Collection (gastropods, bivalves, worms; Late Cretaceous, Belgium)
Denayer, Julien ULg; Fischer, Valentin ULg; Mottequin, Bernard ULg

in Cretaceous Research (2014), 47

A significant part of the collection of mid- and Late Cretaceous (Cenomanian, Campanian and Maastrichtian) gastropods, bivalves and worms described and/or illustrated by de Ryckholt in his seminal work ... [more ▼]

A significant part of the collection of mid- and Late Cretaceous (Cenomanian, Campanian and Maastrichtian) gastropods, bivalves and worms described and/or illustrated by de Ryckholt in his seminal work Mélanges paléontologiques between 1854 and 1862, has recently been retraced in the historical collections at Liège University. Of the original collection, more than 206 specimens, including 196 nominal types (lectotypes and genotypes), all considered lost, are now available. The genotypes of the gastropod genera Tudicula de Ryckholt, 1862a and Prosopostoma de Ryckholt, 1862a are photographically illustrated for the first time. Prosopostoma bucculans, from the Cenomanian Bernissart Formation (formerly ‘Tourtia de Tournai’), is here chosen as the type species of the genus Prosopostoma, a possible stromboid. We also reassess the stratigraphic age of the type localities under the revised stratigraphic framework of Belgium and a detailed account on the research history of this material, in order to provide a thorough scientific background for future study of this formidable collection. [less ▲]

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See detailAvaliação da Qualidade de Vida Infantil: O Inventário Sistémico de Qualidade de Vida para Crianças
Fonseca, Marta; Missotten, Pierre ULg; Etienne, Anne-Marie ULg et al

in Psicologia, Reflexão e Crítica = Psychology, Reflection and Criticism (2014), 27(2),

Introduction: Children’s quality of life evaluation has specific methodological aspects. Objective: To examine the psychometric properties of the Portuguese version of the Child Quality of Life Systemic ... [more ▼]

Introduction: Children’s quality of life evaluation has specific methodological aspects. Objective: To examine the psychometric properties of the Portuguese version of the Child Quality of Life Systemic Inventory (CQLSI), which is based on an innovative conceptual and methodological approach to quality of life self-assessment, namely by being interactive and playful, having a psychometry which operates several scores and allowing an analysis of each domain of life. Methods: 120 Portuguese children, from 8 to 12 years old. Results: Internal consistency of the four scores of the CQLSI (State, Goal, Rank and Gap) is satisfactory; all scores have their own specificity. Data show convergent validity. On the other hand, no satisfactory factorial structure was found. Conclusion: Feasibility and psychometric adequacy of the CQLSI Portuguese version seems demonstrated. [less ▲]

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See detailPharmacokinetics in patients with chronic liver disease and hepatic safety of incretin-based therapies for the management of type 2 diabetes mellitus.
Scheen, André ULg

in Clinical pharmacokinetics (2014), 53(9), 773-85

Patients with type 2 diabetes mellitus have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis, and about one-third of cirrhotic patients have ... [more ▼]

Patients with type 2 diabetes mellitus have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis, and about one-third of cirrhotic patients have diabetes. However, the use of several antidiabetic agents, such as metformin and sulphonylureas, may be a concern in case of hepatic impairment (HI). New glucose-lowering agents targeting the incretin system are increasingly used for the management of type 2 diabetes. Incretin-based therapies comprise oral inhibitors of dipeptidyl peptidase-4 (DPP-4) (gliptins) or injectable glucagon-like peptide-1 (GLP-1) receptor agonists. This narrative review summarises the available data regarding the use of both incretin-based therapies in patients with HI. In contrast to old glucose-lowering agents, they were evaluated in specifically designed acute pharmacokinetic studies in patients with various degrees of HI and their hepatic safety was carefully analysed in large clinical trials. Only mild changes in pharmacokinetic characteristics of DPP-4 inhibitors were observed in patients with different degrees of HI, presumably without major clinical relevance. GLP-1 receptor agonists have a renal excretion rather than liver metabolism. Specific pharmacokinetic data in patients with HI are only available for liraglutide. No significant changes in liver enzymes were reported with DPP-4 inhibitors or GLP-1 receptor agonists, alone or in combination with various other glucose-lowering agents, in clinical trials up to 2 years in length. On the contrary, preliminary data suggested that incretin-based therapies may be beneficial in patients with CLD, more particularly in the presence of non-alcoholic fatty liver disease. Nevertheless, caution should be recommended, especially in patients with advanced cirrhosis, because of a lack of clinical experience with incretin-based therapies in these vulnerable patients. [less ▲]

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See detailDiscussion of "Two-dimensional depth-averaged finite volume model for unsteady turbulent flows"
Erpicum, Sébastien ULg; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Research (2014), 52(1), 148-150

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See detailLa primauté de l'intentionnalité et ses conséquences épistémologiques
Boccaccini, Federico ULg

in Bulletin d'Analyse Phénoménologique (2014)

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See detailEvent-triggered transmission for linear control over communication channels
Forni, Fulvio ULg; Galeani, Sergio; Nesic, Dragan et al

in Automatica (2014), 50(2), 490498

We consider an exponentially stable closed loop interconnection of a continuous linear plant and a continuous linear controller, and we study the problem of interconnecting the plant output to the ... [more ▼]

We consider an exponentially stable closed loop interconnection of a continuous linear plant and a continuous linear controller, and we study the problem of interconnecting the plant output to the controller input through a digital channel. We propose a family of "transmission-lazy" sensors whose goal is to transmit the measured plant output information as little as possible while preserving closed-loop stability. In particular, we propose two transmission policies, providing conditions on the transmission parameters. These guarantee global asymptotic stability when the plant state is available or when an estimate of the state is available (provided by a classical continuous linear observer). Moreover, under a specific condition, they guarantee global exponential stability [less ▲]

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See detailOsteonecrosis of the jaw in a male osteoporotic patient treated with denosumab
NEUPREZ, Audrey ULg; Coste, S; Rompen, Eric ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the ... [more ▼]

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk. [less ▲]

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See detailCarbonate Mounds: from Paradox to World Heritage
Henriet, Jean-Pierre; Hamoumi, N.; Da Silva, Anne-Christine ULg et al

in Marine Geology (2014), 352

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See detailUpper airway imaging in sleep-disordered breathing.
POIRRIER, Anne-Lise ULg; Fanielle, Julien; Bruwier, Annick ULg et al

in Acta neurologica Belgica (2014)

Our understanding of sleep-disordered breathing has evolved considerably over the past three decades, and clinical techniques of evaluation have progressed tremendously. Myriad imaging techniques are now ... [more ▼]

Our understanding of sleep-disordered breathing has evolved considerably over the past three decades, and clinical techniques of evaluation have progressed tremendously. Myriad imaging techniques are now available for the physician to approach the dynamic features resulting in turbulent airflow, upper airway narrowing or collapse at different levels. Controversy exists in the choice of investigations, probably because the best evaluation should be a combination of different techniques. Physical, radiographic, endoscopic and acoustic evaluations could be integrated to understand the degree and the levels of airway reduction and/or obstruction in a given patient. This review focuses on cost-effective and easily implemented techniques in daily practice, allowing quality assessment of the dynamic anatomy of sleep-disordered breathing: cephalometry, (sleep-)endoscopy and acoustic reflectometry of the upper airway. [less ▲]

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See detailCurrent challenges in the treatment of osteoporosis: an opportunity for bazedoxifene.
Reginster, Jean-Yves ULg; Ferrari, Serge; Hadji, Peyman

in Current medical research and opinion (2014), 30(6), 1165-1176

Abstract Background: Osteoporosis affects millions of postmenopausal women worldwide. Osteoporosis-related fractures can lead to chronic pain, disability, systemic complications, and increased risk of ... [more ▼]

Abstract Background: Osteoporosis affects millions of postmenopausal women worldwide. Osteoporosis-related fractures can lead to chronic pain, disability, systemic complications, and increased risk of recurrent fractures, resulting in increased healthcare costs and mortality. Because currently available therapies have unique benefit/risk profiles, challenges remain in selecting the most appropriate treatment for each osteoporotic woman. Research and Results: Bazedoxifene (BZA), a new selective estrogen receptor modulator, is being developed for postmenopausal osteoporosis. In a 3-year, global, phase 3 study, BZA significantly reduced the risk of new vertebral fractures and nonvertebral fractures in women with higher baseline fracture risk compared with placebo. In 2 extensions of this study, the efficacy of BZA in reducing vertebral fracture risk was sustained over 7 years. BZA improved lumbar spine and total hip bone mineral density compared with placebo at 3 and 5 years, and demonstrated a favorable safety/tolerability profile, with no endometrial or breast stimulation. BZA was cost-effective compared with raloxifene in a 3-year, head-to-head comparative trial. Indirect comparisons further suggest that BZA may be as effective as bisphosphonates in reducing risk of nonvertebral fractures in women at high risk of fracture. BZA demonstrated efficacy and safety for treating postmenopausal osteoporosis over 7 years, particularly in women at a higher fracture risk. Conclusion: Because of its specific pharmacologic profile, BZA may be appropriate for postmenopausal women seeking a tolerable, safe, effective, and cost-effective long-term osteoporosis treatment. [less ▲]

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See detailIdentification of 1-methyloctyl butanoate as the major sex pheromone component from females of the saddle gall midge, Haplodiplosis marginata (Diptera: Cecidomyiidae)
Censier, Florence ULg; Fischer, Christophe ULg; Pascal, Laurent et al

in Chemoecology (2014)

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective ... [more ▼]

The saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), has undergone a resurgence recently as a pest of cereals in Belgium and other European countries. An effective monitoring tool of saddle gall midge flights is needed in order to understand the enigmatic population dynamics of this pest, and to design an integrated management strategy. Therefore, volatile compounds emitted by females (alkan-2-ols and alk-2-yl butanoates) were identified, and the chirality of the emitted esters was determined to be the R absolute configuration. In field-trapping experiments, racemic non-2-yl butanoate attracted substantial numbers of H. marginata males. Thus, this compound will be useful in baited traps for monitoring seasonal flight patterns, and improving integrated management of the saddle gall midge in agricultural systems. [less ▲]

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See detailHigher long-lasting ethanol sensitization after adolescent ethanol exposure in mice
Quoilin, Caroline; Didone, Vincent ULg; Tirelli, Ezio ULg et al

in Psychopharmacology (2014), 231

Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is ... [more ▼]

Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is a possible consequence of ethanol exposure during adolescence. Objectives. The aim of this study was to characterize the long-term alterations in the stimulant effects of ethanol and in the rate of ethanol sensitization in mice pre-exposed to ethanol during adolescence in comparison to mice pre-exposed to ethanol in adulthood. Methods. Adolescent and adult female SWISS mice were injected with saline or ethanol (2.5 or 4 g/kg) during 14 consecutive days. After a three weeks period of ethanol abstinence, mice were tested as adults before and after a second exposure to daily repeated ethanol injections. Results. All mice pre-exposed to ethanol as adults or adolescents showed higher stimulant effects when re-exposed to ethanol three weeks later. However, this enhanced sensitivity to the stimulant effects of ethanol was of significantly higher magnitude in mice repeatedly injected with high ethanol doses (4g/kg) during adolescence. Furthermore, the increased expression of ethanol stimulant effects in these mice was maintained even after a second procedure of ethanol sensitization. Conclusions. Adolescence is a critical period for the development of a sensitization to ethanol stimulant properties providing that high intermittent ethanol doses are administered. These results might contribute to explain the relationship between age at first alcohol use and risks of later alcohol problems and highlight the dangers of repeated consumption of high alcohol amounts in young adolescents. [less ▲]

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See detailProduction of dissolved organic matter by phytoplankton and its uptake by heterotrophic prokaryotes in large tropical lakes
Morana, Cédric; Sarmento, Hugo; Descy, Jean-Pierre et al

in Limnology & Oceanography (2014), 59(4), 1364-1375

In pelagic ecosystems, phytoplankton extracellular release can extensively subsidize the heterotrophic prokaryotic carbon demand. Time-course experiments were carried out to quantify primary production ... [more ▼]

In pelagic ecosystems, phytoplankton extracellular release can extensively subsidize the heterotrophic prokaryotic carbon demand. Time-course experiments were carried out to quantify primary production, phytoplankton excretion, and the microbial uptake of freshly released dissolved organic carbon (DOC) derived from phytoplankton extracellular release (DOCp) in four large tropical lakes distributed along a productivity gradient: Kivu, Edward, Albert, and Victoria. The contributions of the major heterotrophic bacterial groups to the uptake of DOCp was also analyzed in Lake Kivu, using microautoradiography coupled to catalyzed reporter deposition fluorescent in situ hybridization. The percentage of extracellular release (PER) varied across the productivity gradient, with higher values at low productivity. Furthermore, PER was significantly related to high light and low phosphate concentrations in the mixed layer and was comparatively higher in oligotrophic tropical lakes than in their temperate counterparts. Both observations suggest that environmental factors play a key role in the control of phytoplankton excretion. Standing stocks of DOCp were small and generally contributed less than 1% to the total DOC because it was rapidly assimilated by prokaryotes. In other words, there was a tight coupling between the production and the heterotrophic consumption of DOCp. None of the major phylogenetic bacterial groups that were investigated differed in their ability to take up DOCp, in contrast with earlier results reported for standard labeled single-molecule substrates (leucine, glucose, adenosine triphosphate). It supports the idea that the metabolic ability to use DOCp is widespread among heterotrophic prokaryotes. Overall, these results highlight the importance of carbon transfer between phytoplankton and bacterioplankton in large African lakes. [less ▲]

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See detailEffectiveness of PHARMAceutical care for patients with COPD (PHARMACOP): a randomized controlled trial
Tommelein, Eline; Mehuys, Els; Van Hees, Thierry ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 756-766

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary ... [more ▼]

AIM: Few well-designed randomized controlled trials (RCT) regarding the impact of community pharmacist interventions on pharmacotherapeutic monitoring of patients with Chronic Obstructive Pulmonary Disease (COPD) have been conducted. We assessed the effectiveness of a pharmaceutical care program for patients with COPD. METHODS: The PHARMACOP-trial is a single-blind 3-month RCT, conducted in 170 community pharmacies in Belgium, enrolling patients prescribed daily COPD medication, aged >/=50 years, and with a smoking history >/=10 pack-years. A computer-generated randomization sequence allocated patients to intervention (n=371), receiving protocol-defined pharmacist care, or control group (n=363), receiving usual pharmacist care (1:1 ratio, stratified by center). Interventions, focusing on inhalation technique and adherence to maintenance therapy, were carried out at start of the trial and at one month follow-up. Primary outcomes were inhalation technique and medication adherence. Secondary outcomes were exacerbation rate, dyspnea, COPD specific and generic health status and smoking behavior. RESULTS: From December 2010 to April 2011, 734 patients were enrolled. 42 patients (5.7%) were lost to follow-up. At the end of the trial, inhalation score (Mean estimated difference [Delta],13.5%; 95% Confidence Interval [CI], 10.8-16.1; P<.0001) and medication adherence (Delta, 8.51%; 95%CI, 4.63-12.4; P<.0001) were significantly higher in the intervention group compared to the control group. In the intervention group, a significantly lower hospitalization rate was observed (9 vs 35; Rate Ratio, 0.28; 95%CI, 0.12-0.64; P=.003). No other significant between-group differences were observed. CONCLUSION: Pragmatic pharmacist care programs improve the pharmacotherapeutic regime in patients with COPD and could reduce hospitalization rates. [less ▲]

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See detailA Critical Assessment of Approaches to Outpatient Monitoring.
Appelboom, Geoff; Sussman, Eric S.; Raphael, Pierre et al

in Current medical research and opinion (2014)

Abstract N/A.

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See detailBone forming agents for the management of osteoporosis
Reginster, Jean-Yves ULg; Neuprez, A.; Beaudart, Charlotte ULg et al

in Panminerva medica (2014), 56(2), 97-114

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these ... [more ▼]

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these medications provide only limited fracture reduction and may be linked to skeletal and non-skeletal long-term safety concerns. Therefore, some patients are considered candidates for bone-forming agents because they remain severely osteoporotic or because they failed antiresorptive therapy. Over the last decade, a particular interest was shown in the developmentofmedicationsabletoincreaseosteoblastsnumber,lifespan or activity, hence stimulating bone formation Peptides from the parathyroid hormone family and strontium ranelate were shown to significantly reduce fracture rates but strontium ranelate is no longer an option for treating osteoporosis because of its safety profile. New therapeutic options, including monoclonal antibodies against sclerostin seem to be promising but their role in the armamentarium of osteoporosis will depend on the results of the current phase 3 studies, assessing antifracture efficacy and long-term safety. [less ▲]

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See detailSocial Security and Family Support
Leroux, Marie Louise; Pestieau, Pierre ULg

in Canadian Journal of Economics (2014), 47(1), 115-143

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See detailRecouvrement d'un crédit hypothécaire et accumulation des intérêts
Biquet, Christine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2014), (5), 205-216

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See detailCharacteristics and ceramic properties of clayey ma terials from Amezmiz region (Western High Atlas, Morocco)
Daoudi, Lahcen; El Boudour El Idrissi, Hicham ULg; Saadi, Latifa et al

in Applied Clay Science (2014)

Five clayey materials from two quarries located in the Amezmiz region (Morocco) were sampled and investigated for their physical, chemical, mineralogical and thermal characteristics to evaluate their ... [more ▼]

Five clayey materials from two quarries located in the Amezmiz region (Morocco) were sampled and investigated for their physical, chemical, mineralogical and thermal characteristics to evaluate their potential suitability as raw materials in various ceramic applications. Physical properties were identified by particle size distribution, consistency limits and total organic content. Chemical, mineralogical, and thermal properties were investigated by XRF, XRD, and TG/DTA techniques, respectively. A common raw material in pottery manufacturing of Morocco was used as reference sample (REF). Results show that the main oxides in the samples were SiO2, Al2O3, and Fe2O3, whereas the other oxides were present only in small quantities. Quartz, illite and vermiculite were present as dominant mineral phases with minor kaolinite, calcite and smectite. The results showed that three of the studied clayey materials have adequate characteristics for the production of structural ceramics. However, for the two other clays it is necessary to add more plastic clays to enhance the workability. [less ▲]

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See detailThe relationship between working memory for serial order and numerical development: a longitudinal study
Attout, Lucie ULg; Noël, Marie-Pascale; Majerus, Steve ULg

in Developmental Psychology (2014), 50(6), 1667-1679

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