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See detailImplicit learning: A way to improve visual search in spatial neglect?
Wansard, Murielle ULg; Geurten, Marie ULg; Colson, Catherine et al

in Consciousness & Cognition (2016)

Studies have shown that neglect patients are able to use stimulus regularities to orient faster toward the neglected side, without necessarily being aware of that information, or at the very least without ... [more ▼]

Studies have shown that neglect patients are able to use stimulus regularities to orient faster toward the neglected side, without necessarily being aware of that information, or at the very least without being able to verbalize their knowledge. In order to better control for the involvement of explicit processes, the present study sought to test neglect patients’ ability to detect more complex associations between stimuli using tasks similar to those used in implicit learning studies. Our results demonstrate that neglect patients had difficulties implicitly learning complex associations, contrary to what we found with controls. The possible influence of attentional and working memory impairments are discussed. [less ▲]

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See detailMecanismes de l'effet diuretique de la cafeine.
Marx, Barbara; Scuvee, Eleonore; Scuvée-Moreau, Jacqueline ULg et al

in Medecine sciences : M/S (2016), 32(5), 485-90

Caffeine is an alkaloid which belongs to the family of methylxanthines and is present in beverages, food and drugs. Caffeine competitively antagonizes the adenosine receptors (AR), which are G protein ... [more ▼]

Caffeine is an alkaloid which belongs to the family of methylxanthines and is present in beverages, food and drugs. Caffeine competitively antagonizes the adenosine receptors (AR), which are G protein-coupled receptors largely distributed throughout the body, including brain, heart, vessels and kidneys. Caffeine consumption has a well-known diuretic effect. The homeostasis of salt and water involves different segments of the nephron, in which adenosine plays complex roles depending on the differential expression of AR. Hence, caffeine increases glomerular filtration rate by opposing the vasoconstriction of renal afferent arteriole mediated by adenosine via type 1 AR during the tubuloglomerular feedback. Caffeine also inhibits Na(+) reabsorption at the level of renal proximal tubules. In addition, caffeine perturbs the hepatorenal reflex via sensory nerves in Mall's intrahepatic spaces. Here, we review the physiology of caffeine-induced natriuresis and diuresis, as well as the putative pathological implications. [less ▲]

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See detailVALIDATION OF THE FRENCH VERSION OF THE PARENTING STRESS INDEX–SHORT FORM (FOURTH EDITION)
Toucheque, Malorie ULg; Etienne, Anne-Marie ULg; Stassart, Céline ULg et al

in Journal of Community Psychology (2016), 44(4), 419-425

Introduction: The Parenting Stress Index (PSI) is widely used to measure stress related to the demands of parenthood. Unfortunately, no French adaptation and validation of the PSI Short Form (Fourth ... [more ▼]

Introduction: The Parenting Stress Index (PSI) is widely used to measure stress related to the demands of parenthood. Unfortunately, no French adaptation and validation of the PSI Short Form (Fourth Edition) had yet been published. This study examine the factor structure and the psychometric properties of the French translation of the PSI-4-SF. Method: Sample consists of 210 parents of children aged 5 to 12 years old. Factor structure of the PSI-4-SF was investigated using confirmatory factor analysis (CFA). Three models were tested, with one, two and three dimensions. Internal consistency reliability and validity were also examined. Results: CFA showed that the original three-factor solution most closely approximated our data despite the imperfection of the model fit indices. Results also indicated a good internal consistency reliability and validity. Conclusion: The French version of the PSI-4-SF shows promise as a valuable instrument for assessing parenting stress in the French-speaking population. [less ▲]

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See detailRhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota.
Neyrinck, Audrey M.; Etxeberria, Usune; Taminiau, Bernard ULg et al

in Molecular Nutrition & Food Research (2016)

SCOPE: Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by inflammation and oxidative stress, which could be promoted by gut barrier function ... [more ▼]

SCOPE: Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by inflammation and oxidative stress, which could be promoted by gut barrier function alterations. In this study, we have tested the hypothesis of the hepatoprotective effect of rhubarb extract in a mouse model of binge drinking and we explored the contribution of the gut microbiota in the related- metabolic effects. METHODS AND RESULTS: Mice were fed a control diet supplemented with or without 0.3% rhubarb extract for 17 days and were necropsied 6 hours after an alcohol challenge. Supplementation with rhubarb extract changed the microbial ecosystem (assessed by 16S rDNA pyrosequencing) in favor of Akkermansia muciniphila and Parabacteroides goldsteinii. Furthermore, it improved alcohol-induced hepatic injury, down-regulated key markers of both inflammatory and oxidative stresses in the liver tissue, without affecting significantly steatosis. In the gut, rhubarb supplementation increased crypt depth, tissue weight, the expression of antimicrobial peptides. CONCLUSIONS: These findings suggest that some bacterial genders involved in gut barrier function, are promoted by phytochemicals present in rhubarb extract, and could therefore be involved in the modulation of the susceptibility to hepatic diseases linked to acute alcohol consumption. This article is protected by copyright. All rights reserved. [less ▲]

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See detailNon-monotonous anisotropy in charge conduction induced by antiferrodistortive transition in metallic SrTiO3
Tao, Qian; Loret, Bastien; Xu, Bin ULg et al

in Physical Review B (2016), 94

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See detailGender effect on the scapular 3D posture and kinematic in healthy subjects
Schwartz, Cédric ULg; Croisier, Jean-Louis ULg; Rigaux, Elise et al

in Clinical Physiology and Functional Imaging (2016)

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However ... [more ▼]

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However the literature reports, for the shoulder, differences in the range of motion between genders. The specific influence of gender on the scapula-thoracic kinematics has not been studied yet. The dominant shoulder of two populations of men and women composed of 11 subjects each were evaluated in three dimensions for three distinct motions: flexion in the sagittal plane, abduction in the frontal plane and gleno-humeral internal/external rotation with the arm abducted at 90°. Posture, kinematics and range of motion were studied separately. For flexion and abduction and with regard to the scapular kinematic, external rotation were significantly larger for women than men. The differences were of at least 5° at 120° of humeral elevation. Upward rotations were identical. Women also showed larger average active humero-thoracic range of motion. The mean differences were of 13°, 7°, 12° and 5° for abduction, flexion, internal rotation and external rotation, respectively. No difference was observed between the scapular resting positions of both populations. The observed differences concerning both the scapular and humeral patterns would indicate that the shoulder behavior of men and women should not be expected to be similar. [less ▲]

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See detailRecommendations for the imaging assessment of prosthetic heart valves: a report from the European Association of Cardiovascular Imaging endorsed by the Chinese Society of Echocardiography, the Inter-American Society of Echocardiography, and the Brazilian Department of Cardiovascular Imaging.
Lancellotti, Patrizio ULg; Pibarot, Philippe; Chambers, John et al

in European heart journal cardiovascular Imaging (2016)

Prosthetic heart valve (PHV) dysfunction is rare but potentially life-threatening. Although often challenging, establishing the exact cause of PHV dysfunction is essential to determine the appropriate ... [more ▼]

Prosthetic heart valve (PHV) dysfunction is rare but potentially life-threatening. Although often challenging, establishing the exact cause of PHV dysfunction is essential to determine the appropriate treatment strategy. In clinical practice, a comprehensive approach that integrates several parameters of valve morphology and function assessed with 2D/3D transthoracic and transoesophageal echocardiography is a key to appropriately detect and quantitate PHV dysfunction. Cinefluoroscopy, multidetector computed tomography, cardiac magnetic resonance imaging, and to a lesser extent, nuclear imaging are complementary tools for the diagnosis and management of PHV complications. The present document provides recommendations for the use of multimodality imaging in the assessment of PHVs. [less ▲]

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See detailAssessment of partial coalescence in whippable oil-in-water food emulsions
Petrut, Raul Flaviu ULg; Danthine, Sabine ULg; Blecker, Christophe ULg

in Advances in Colloid and Interface Science (2016), (229), 25-33

Partial coalescence influences to a great extent the properties of final food products such as ice cream and whipped toppings. In return, the partial coalescence occurrence and development are conditioned ... [more ▼]

Partial coalescence influences to a great extent the properties of final food products such as ice cream and whipped toppings. In return, the partial coalescence occurrence and development are conditioned, in such systems, by the emulsion's intrinsic properties (e.g. solid fat content, fat crystal shape and size), formulation (e.g. protein content, surfactants presence) and extrinsic factors (e.g. cooling rate, shearing). A set of methods is available for partial coalescence investigation and quantification. These methods are critically reviewed in this paper, balancing the weaknesses of themethods in terms of structure alteration (for turbidity, dye dilution, etc.) and assumptions made for mathematical models (for particle size determination) with their advantages (good repeatability, high sensitivity, etc.).With the methods proposed in literature, the partial coalescence investigations can be conducted quantitatively and/or qualitatively. Good correlation were observed between some of the quantitative methods such as dye dilution, calorimetry, fat particle size;while a poor correlation was found in the case of solvent extraction method with other quantitativemethods. The most suitableway for partial coalescence quantification was implied to be the fat particle size method, which would give results with a high degree of confidence if used in combination with a microscopic technique for the confirmation of partial coalescence as the main destabilization mechanism. [less ▲]

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See detailCore Outcome Measure Index for low back patients: do we miss anxiety and depression?
Cedraschi, C; Marty, M; Courvoisier, DS et al

in European Spine Journal (2016), 25

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See detailA single amino acid substitution toggles chloride dependence of the alpha-amylase paralog Amyrel in Drosophila melanogaster and Drosophila virilis species
Claisse, G.; Feller, Georges ULg; Bonneau, M. et al

in Insect Biochemistry and Molecular Biology (2016), 75

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See detailPhotocatalytic decomposition of hydrogen peroxide over nanoparticles of TiO2 and Ni(II)-porphyrin doped TiO2: a relationship between activity and porphyrin anchoring mode
Tasseroul, Ludivine ULg; Pàez Martinez, Carlos ULg; Lambert, Stéphanie ULg et al

in Applied Catalysis B : Environmental (2016), 182

The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared ... [more ▼]

The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared spectroscopy and thermal gravimetry combined with differential scanning calorimetry measurements allowed the determination of the TCPPNi anchoring mode. At low TCPPNi concentrations, this anchoring on Degussa P25 TiO2 took place through all four carboxylic groups, while at higher concentrations the anchoring occurred through one or two carboxylic groups. For the firsttime,the effect of UV/vis light irradiation on the H2O2-degradation activity of TiO2 and TCPPNi-doped TiO2 was studied using the method of following the production of O2 by gas pressure monitoring. The activity of seven different catalysts was related to the TCPPNi anchoring mode and the percentage of TiO2 Degussa P25 coverage. An optimum degradation of H2O2 was observed for 0.0115 mol TCPPNi × g−1 P25. In that case, the TCPPNi was anchored through the four carboxylic groups, corresponding to a strong interaction with Degussa P25 TiO2. Moreover, the TCPPNi did not cover the surface completely, therefore allowing the light to reach and activate the TiO2. [less ▲]

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See detailDialects in Pre-Coptic Egyptian. With a special attention to Late Egyptian
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (2016), 23

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See detailDoped sol–gel films vs. powders TiO2: On the positive effect induced by the presence of a substrate
Léonard, Géraldine ULg; Malengreaux, Charline; Melotte, Quentin et al

in Journal of Environmental Chemical Engineering (2016), 4

SiO2 and Ag–SiO2 doped TiO2 films and powders have been produced using a controlled sol–gel process. The dopant has been introduced using an alkoxysilane-functionalized ligand, with or without complexed ... [more ▼]

SiO2 and Ag–SiO2 doped TiO2 films and powders have been produced using a controlled sol–gel process. The dopant has been introduced using an alkoxysilane-functionalized ligand, with or without complexed silver ions. The influence of dopants on physico-chemical properties of the catalysts is studied by XRD, TEM–EDX, DRUV–vis analyses in the case of powders, while GIXRD, XPS, profilometry, UV–vis absorption analyses have been used for thin films. The photocatalytic activity has been evaluated from the degradation of methylene blue under UV-A light in the presence of the different catalysts over a period of 24 h. The detailed comparison between powders and films highlights a surprising positive effect in the case of films due to the presence of the substrate. In the case of photocatalytic powders, the presence of SiO2 or Ag–SiO2 into the TiO2 matrix has a detrimental effect on the photocatalytic activity while the opposite tendency is observed in the case of films, with best activities obtained with Ag–SiO2 doping. Different factors, in particular crystallinity modification between powders and films, have been studied to explain these opposite behaviors. In the case of powders, crystallization is hindered by SiO2 and Ag particles incorporation into the TiO2 matrix, leading to a decrease of the photocatalytic activity. In the case of thin films, probably because of the presence of a substrate, crystallization is not influenced by the presence of SiO2 and Ag particles. Therefore, the latter ones can fully play their role of electron traps leading to an enhanced photocatalytic activity. [less ▲]

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See detailKinetic Studies on CphA Mutants Reveal the Role of the P158-P172 Loop in Activity versus Carbapenems.
Bottoni, Carlo; Perilli, Mariagrazia; Marcoccia, Francesca et al

in Antimicrobial Agents and Chemotherapy (2016), 60(5), 3123-6

Site-directed mutagenesis of CphA indicated that prolines in the P158-P172 loop are essential for the stability and the catalytic activity of subclass B2 metallo-beta-lactamases against carbapenems. The ... [more ▼]

Site-directed mutagenesis of CphA indicated that prolines in the P158-P172 loop are essential for the stability and the catalytic activity of subclass B2 metallo-beta-lactamases against carbapenems. The sequential substitution of proline led to a decrease of the catalytic efficiency of the variant compared to the wild-type (WT) enzyme but also to a higher affinity for the binding of the second zinc ion. [less ▲]

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See detailSynthèse bibliographique sur le comportement de recherche de l’hôte chez la punaise de lit (Cimex lectularius) et applications dans le cadre de la lutte intégrée
Legrand, Pauline ULg; Verheggen, François ULg; Haubruge, Eric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(2),

This study analyzes host-seeking behavior in the common bed bug, Cimex lectularius, paying particular attention to human stimuli involved in this orientation process. The potential applications in ... [more ▼]

This study analyzes host-seeking behavior in the common bed bug, Cimex lectularius, paying particular attention to human stimuli involved in this orientation process. The potential applications in integrated pest management are discussed. The common bed bug is an obligate hematophagous that has been associated with humans for millennia. When searching for food, this insect relies for orientation on signals produced by its hosts. Carbon dioxide emitted by human respiration is more attractive to bugs than body heat. The response of bed bugs to other volatile organic compounds released by the human body has been tested, but their perception and behavioral impact are not always studied together, and some discrepancies occasionally appear. Currently, carbon dioxide is the most efficient lure for bed bugs, although real human bait is more attractive. Some home-made traps baited with dry ice are more efficient than other traps using complicated chemical blends. Dry ice seems to be more efficient as a lure than complex chemical blends, and it can be used in simple traps. Our knowledge of host-seeking behavior in bed bugs is still partial and new questions are constantly arising. Further efforts in the study of the chemical ecology of this process are needed in order to improve the management of this pest. The control of bed bugs in European countries appears to be a major challenge for the years to come. [less ▲]

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See detailEvaluation of a New Method for the Treatment of Invasive, Diffuse, and Unexcisable Lymphangiomas of the Oral Cavity with Defocus CO2 Laser Beam: A 20-Year Follow-Up
Namour, Samir ULg; VAN HEUSDEN, Alain ULg; Namour, Amaury et al

in Photomedicine and Laser Surgery (2016), 34(2), 82-87

Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and ... [more ▼]

Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and unexcisable oral lymphangiomas. Background data: Cystic lymphatic malformations, or lymphangiomas, are mature lymphatic malformations, consisting of abnormal lymphatic vessels. Surgical excision is considered by most surgeons to be the treatment of choice for lymphangioma. Laser beam has been used to treat superficial or small lymphatic malformations by excision or by photocoagulation, and to excise or photocoagulate small lymphangiomas. Patients and methods: Seventeen patients with diffuse and unexcisable lymphangiomas were treated using a CO2 laser with specific settings: beam was 2W in noncontact and defocus mode, power density was 0.63W/cm2 for irradiation time in the range of 3– 5min, and the estimated energy density range was 114.65–191.02 J/cm2. The beam diameter at the tissular impact point was –2 cm. The laser beam was defocused to provoke a deep heat generation that would dry up the lymphatic tissues and induce deep tissue necrosis that heals by fibrous tissue process. Results: The results were satisfactory and stable, with localized recurrence in three cases. The recurrent areas were re-treated using the same technique successfully and with no further recurrence. Conclusions: The use of CO2 laser under the suggested irradiation conditions can be considered a useful technique for the treatment of invasive lymphangiomas. [less ▲]

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See detailBovine Herpesvirus 4 Modulates Its beta-1,6-N-Acetylglucosaminyltransferase Activity through Alternative Splicing.
Lété, Céline ULg; Markine-Goriaynoff, Nicolas; Machiels, Bénédicte ULg et al

in Journal of virology (2016), 90(4), 2039-51

Carbohydrates play major roles in host-virus interactions. It is therefore not surprising that, during coevolution with their hosts, viruses have developed sophisticated mechanisms to hijack for their ... [more ▼]

Carbohydrates play major roles in host-virus interactions. It is therefore not surprising that, during coevolution with their hosts, viruses have developed sophisticated mechanisms to hijack for their profit different pathways of glycan synthesis. Thus, the Bo17 gene of Bovine herpesvirus 4 (BoHV-4) encodes a homologue of the cellular core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M), which is a key player for the synthesis of complex O-glycans. Surprisingly, we show in this study that, as opposed to what is observed for the cellular enzyme, two different mRNAs are encoded by the Bo17 gene of all available BoHV-4 strains. While the first one corresponds to the entire coding sequence of the Bo17 gene, the second results from the splicing of a 138-bp intron encoding critical residues of the enzyme. Antibodies generated against the Bo17 C terminus showed that the two forms of Bo17 are expressed in BoHV-4 infected cells, but enzymatic assays revealed that the spliced form is not active. In order to reveal the function of these two forms, we then generated recombinant strains expressing only the long or the short form of Bo17. Although we did not highlight replication differences between these strains, glycomic analyses and lectin neutralization assays confirmed that the splicing of the Bo17 gene gives the potential to BoHV-4 to fine-tune the global level of core 2 branching activity in the infected cell. Altogether, these results suggest the existence of new mechanisms to regulate the activity of glycosyltransferases from the Golgi apparatus. IMPORTANCE: Viruses are masters of adaptation that hijack cellular pathways to allow their growth. Glycans play a central role in many biological processes, and several studies have highlighted mechanisms by which viruses can affect glycosylation. Glycan synthesis is a nontemplate process regulated by the availability of key glycosyltransferases. Interestingly, bovine herpesvirus 4 encodes one such enzyme which is a key enzyme for the synthesis of complex O-glycans. In this study, we show that, in contrast to cellular homologues, this virus has evolved to alternatively express two proteins from this gene. While the first one is enzymatically active, the second results from the alternative splicing of the region encoding the catalytic site of the enzyme. We postulate that this regulatory mechanism could allow the virus to modulate the synthesis of some particular glycans for function at the location and/or the moment of infection. [less ▲]

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See detailPrevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: A Randomized Controlled Trial.
Muysoms, Filip E.; DETRY, Olivier ULg; Vierendeels, Tijl et al

in Annals of surgery (2016), 263(4), 638-645

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high ... [more ▼]

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high risk of incisional hernia. METHODS: A multicenter randomized trial was conducted on patients undergoing elective abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133). In the study group, retromuscular mesh-augmented reinforcement was performed with a large-pore polypropylene mesh (Ultrapro, width 7.5 cm). The primary endpoint was the incidence of incisional hernias at 2-year follow-up. RESULTS: Between February 2009 and January 2013, 120 patients were recruited at 8 Belgian centers. Patients' characteristics at baseline were similar between groups. Operative and postoperative characteristics showed no difference in morbidity or mortality. The cumulative incidence of incisional hernias at 2-year follow-up after conventional closure was 28% (95% confidence interval [CI], 17%-41%) versus 0% (95% CI, 0%-6%) after mesh-augmented reinforcement (P < 0.0001; Fisher exact test). The estimated "freedom of incisional hernia" curves (Kaplan-Meier estimate) were significantly different across study arms (chi = 19.5, P < 0.0001; Mantel-Cox test). No adverse effect related to mesh-augmented reinforcement was observed, apart from an increased mean time to close the abdominal wall for mesh-augmented reinforcement compared with the control group: 46 minutes (SD, 18.6) versus 30 minutes (SD, 18.5), respectively (P < 0.001; Mann-Whitney U test). CONCLUSIONS: Prophylactic retromuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic aneurysm is safe and effectively prevents the development of incisional hernia during 2 years, with an additional mean operative time of 16 minutes. [less ▲]

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See detailTransatlantic Editorial: a comparison between European and North American guidelines on myocardial revascularization.
Kolh, Philippe ULg; Kurlansky, Paul; Cremer, Jochen et al

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(5), 1307-17

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See detailReal-time remedial action against aperiodic small signal rotor angle instability
Weckesser, Johannes ULg; Jóhannsson, Hjörtur; Østergaard, Jacob

in IEEE Transactions on Power Systems (2016), 31(1), 387-396

This paper presents a method that in real-time determines remedial actions, which restore stable operation with respect to aperiodic small signal rotor angle stability (ASSRAS) when insecure or unstable ... [more ▼]

This paper presents a method that in real-time determines remedial actions, which restore stable operation with respect to aperiodic small signal rotor angle stability (ASSRAS) when insecure or unstable operation has been detected. An ASSRAS assessment method is used to monitor the stability boundary for each generator in real-time. The ASSRAS boundary represents the condition when a generator reaches the maximum steady state active power injection. The proposed control method exploits analytically derived expressions for the ASSRAS boundary and other characteristic curves in the injection impedance plane to determine an active power redispatch among selected generators to restore stable and secure operation. Since the method is purely based on analytically derived expression, the computation of the remedial actions is fast and well suited for real-time operation. The method was tested on the IEEE 14-bus and the Nordic32 test systems where results show that the method can efficiently determine the required active power redispatch to avoid an imminent instability. [less ▲]

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See detailEstradiol-induced neurogenesis in the female accessory olfactory bulb is required for the learning of the male odor.
Brus, Maina; Trouillet, Anne-Charlotte; Hellier, Vincent ULg et al

in Journal of Neurochemistry (2016)

Odors processed by the main and accessory olfactory bulbs (MOB, AOB) are important for sexual behavior. Interestingly, both structures continue to receive new neurons during adulthood. A role for ... [more ▼]

Odors processed by the main and accessory olfactory bulbs (MOB, AOB) are important for sexual behavior. Interestingly, both structures continue to receive new neurons during adulthood. A role for olfactory neurogenesis in sexual behavior in female mice has recently been shown and gonadal hormones such as estradiol can modulate adult neurogenesis. Therefore, we wanted to determine the role of estradiol in learning the odors of sexual partners and in the adult neurogenesis of female aromatase-knockout mice (ArKO), unable to produce estradiol. Female WT and ArKO mice were exposed to male odors during 7 days and olfactory preferences, cell proliferation, cell survival and functional involvement of newborn neurons were analyzed, using BrdU injections, in combination with a marker of cell activation (Zif268) and neuronal fate (DCX, NeuN). Behavioral tasks indicated that both WT and ArKO females were able to discriminate between the odors of two different males, but ArKO mice failed to learn the familiar male odor. Proliferation of newborn cells was reduced in ArKO mice only in the dentate gyrus of the hippocampus. Olfactory exposure decreased cell survival in the AOB in WT females, suggesting a role for estradiol in a structure involved in sexual behavior. Finally, newborn neurons do not seem to be functionally involved in the AOB of ArKO mice compared with WT, when females were exposed to the odor of a familiar male, suggesting that estradiol-induced neurogenesis in the AOB is required for the learning of the male odor in female mice. This article is protected by copyright. All rights reserved. [less ▲]

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See detailEmpédocle, ou comment entrer en philosophie. Sartre et la pensée allemande dans les années 1920
Cormann, Grégory ULg

in Etudes Sartriennes (2016), 20

Comment Sartre est-il entré en philosophie ? Au-delà des petits récits légendaires, tels que ceux que Raymond Aron a laissés à propos de la découverte de la phénoménologie ou de la première formulation de ... [more ▼]

Comment Sartre est-il entré en philosophie ? Au-delà des petits récits légendaires, tels que ceux que Raymond Aron a laissés à propos de la découverte de la phénoménologie ou de la première formulation de la théorie de la contingence pendant les années passées à l’ENS, le présent article vise à établir les conditions dans lesquelles Sartre a formulé à son origine le projet de faire œuvre de philosophe. En pistant le réseau de curiosité intellectuelle pour la pensée allemande dont le titre du manuscrit Empédocle atteste, cet article reconstitue d’abord le milieu intellectuel dans lequel Sartre évolue au milieu des années 1920 avec ses camarades Aron et Nizan, autour des activités du Groupe d’Information Internationale de l’École Normale Supérieure. Comme les Carnets et Les Mots le confirment dans l’après-coup, ce milieu intellectuel fortement « alsacien » lui permet tout à la fois de prolonger et de compliquer – jusqu’à la rupture, peut-être – la vocation à la fois pédagogique et critique que charriait son inscription dans une histoire intellectuelle double, française et allemande. Dans cette étude de la « sociabilité alsacienne » du jeune Sartre et de son rapport avec les premières générations de la germanistique française, la figure de Robert Minder (1902-1980) sert de point de comparaison avec Sartre. La suite de l’article précise la nature du projet philosophique de Sartre dans le rapport qu’il entretient avec la vocation littéraire qui l’a attiré vers des études de philosophie. Dans cette partie, c’est la rencontre personnelle et théorique de Sartre avec Bernard Groethuysen (1880-1946) qui sert de guide. La trajectoire du philosophe allemand permet tout à la fois à Sartre d’articuler la littérature et la philosophie (dans un espace de circulation culturelle franco-allemand) et d’amorcer le passage de l’exigence nietzschéenne d’un recommencement de la philosophie (qui vaut aussi pour l’après-Première Guerre mondiale) avec le programme d’une philosophie rigoureuse déjà incarné chez Groethuysen par la phénoménologie de Husserl. En conclusion, l’article revient sur la façon dont Sartre récupère la situation particulière dans laquelle il rédige son Empédocle – son histoire amoureuse avec Simone Jollivet – en direction d’une philosophie qui expose non seulement le philosophe à une enquête permanente sur soi (Victor Hugo prenant alors le relais de Nietzsche), mais qui soit aussi une entreprise philosophique nouvelle qui conteste de l’intérieur, en la poussant dans ses conséquences extrêmes, la généalogie héroïque – et masculiniste – dont elle est issue. En somme, il s’agit ici, par le truchement d’une lecture symbolique d’un texte de jeunesse, de considérer la philosophie sartrienne au point où elle se précède elle-même, avant la découverte de Heidegger et avant la rencontre de Simone de Beauvoir. Dans cette reconstruction des conditions de possibilité de la philosophie de Sartre – et de Beauvoir – se poursuit dès lors l’entreprise, encore très partiellement réalisée, de faire l’archéologie de la philosophie française contemporaine (selon l’expression d’Alain Badiou) dans l’entre-deux-guerres, à savoir de déterminer la portée critique et historiographique de la phénoménologie existentialiste. [less ▲]

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See detailThe role of personal goals in autonoetic experience when imagining future events
Lehner, Edith; D'Argembeau, Arnaud ULg

in Consciousness & Cognition (2016), 42

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See detailEffect of rifampin on the disposition of brivaracetam in human subjects: further insights into brivaracetam hydrolysis.
Stockis, Armel; Watanabe, Shikiko; Scheen, André ULg et al

in Drug metabolism and disposition: the biological fate of chemicals (2016), 44(6), 792-799

Brivaracetam (BRV) is a high-affinity synaptic vesicle protein 2A ligand developed for the treatment of uncontrolled partial-onset seizures. The present Phase I open-label two-way crossover study was ... [more ▼]

Brivaracetam (BRV) is a high-affinity synaptic vesicle protein 2A ligand developed for the treatment of uncontrolled partial-onset seizures. The present Phase I open-label two-way crossover study was designed to assess the effect of rifampin on the pharmacokinetics of BRV and its hydroxy (BRV-OH); acid (BRV-AC); and hydroxy acid (BRV OHAC) metabolites. Twenty-six healthy subjects received BRV 150mg single oral dose, either alone or following 5 days of rifampin 600 mg/day. BRV and its metabolites were examined for their plasma profiles and urinary excretion. Pharmacokinetic modeling was developed to estimate the rate constants of the various metabolic routes. Parallel in vitro assays were conducted to characterize the hydrolysis of BRV to BRV-AC as well as to identify any potential effect of rifampin on the hydrolysis reaction. Rifampin did not significantly affect the maximum plasma concentration (Cmax) of BRV but decreased its area under the curve (AUC) by 45%. In addition, rifampin significantly increased the AUC of BRV-OH (+109%), decreased the AUC of BRV-AC (-53%), but had little effect on BRV-OHAC (-10%). In vitro assays showed that the major urinary metabolite BRV-AC (33% of the dose) was likely to be formed by amidase EC 3.5.1.4. In vitro data indicated that the enzyme was not significantly inhibited nor induced by rifampin. Modeling confirmed that all the observed changes in vivo were secondary to the induction of the CYP2C19-mediated hydroxylation of BRV to BRV-OH (3.7-fold increase in the rate constant). [less ▲]

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See detailMonitoring the freshness of fish: development of a qPCR method applied to MAP chilled whiting
Dehaut, Alexandre; Krzewinski, Frédéric; Grard, Thierry et al

in Journal of the Science of Food and Agriculture (2016)

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See detailThe clinical challenge of concomitant aortic and mitral valve stenosis.
Unger, Philippe; Lancellotti, Patrizio ULg; de Canniere, Didier

in Acta Cardiologica (2016), 71(1), 3-6

The coexistence of mitral and aortic stenosis is not exceptional. Whereas rheumatic fever is currently plummeting in the Western countries, the incidence of degenerative disease is inversely increasing ... [more ▼]

The coexistence of mitral and aortic stenosis is not exceptional. Whereas rheumatic fever is currently plummeting in the Western countries, the incidence of degenerative disease is inversely increasing. The haemodynamic interactions which may interfere both with the usual echocardiographic parameters and with the invasive assessment may render the diagnosis difficult. The therapeutic challenges raised by this entity should not be underestimated. The increased morbidity and mortality of multivalvular surgery has to be balanced with the risk of a second operation down the line if one valvular involvement, deemed of a lesser importance, is neglected. This complex situation requires the multidisciplinary approach of a heart team involving surgeons, cardiologists, geriatrists if need be and imaging specialists. [less ▲]

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See detailNew data about anatomy, branching, and inferred growth patterns in the Early Devonian plant Armoricaphyton chateaupannense, Montjean-sur-Loire, France
Gerrienne, Philippe ULg; Gensel, PG

in Review of Palaeobotany and Palynology (2016), 224(Part 1), 38-53

This study provides detailed information, based on serial peels, on the anatomy of the primary and secondary xylem, lateral branch formation, and proposed growth pattern of Armoricaphyton Strullu-Derrien ... [more ▼]

This study provides detailed information, based on serial peels, on the anatomy of the primary and secondary xylem, lateral branch formation, and proposed growth pattern of Armoricaphyton Strullu-Derrien et al., an Early Devonian (Pragian) basal euphyllophyte. The centrarch primary xylem strand is circular to oval in cross section and includes P-type tracheids. The pattern of lateral branch departure is described in detail based on serial peels. The secondary xylem, illustrated in transverse, radial and tangential longitudinal sections, includes P-type tracheids with similar pitting in radial and tangential walls. The presence of one-walled spaces interpreted as rays is confirmed. This study also documents the earliest occurrence of secondary xylem at bases of next higher order of branches. A model of growth for this unusual Early Devonian plant is presented, with documented epidogenetic, menetogenetic and possible apoxogenetic phases. The difference in proportion of primary tosecondary xylem is postulated to be a result of this mode of growth. The possible implications of xylem size and organization in the lateral organ in Armoricaphyton relative to the early evolution of the megaphyllous leaf are briefly discussed. [less ▲]

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See detailBott type periodicity for the higher octonions
Kreusch, Marie ULg

in Journal of Noncommutative Geometry (2016), 9(4), 1041-1393

We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions ... [more ▼]

We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions and Clifford algebras. The algebras $\bbO_{n}$ and $\bbO_{p,q}$ with $p+q=n$ have a natural $\Z_2^n$-grading, and they are characterized by cubic forms over the field $\Z_2$. We establish a periodicity for the algebras~$\bbO_{n}$ and $\bbO_{p,q}$ similar to that of the Clifford algebras $\mathrm{Cl}_{n}$ and~$\mathrm{Cl}_{p,q}$. [less ▲]

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See detailDisplacement of an Electrically Charged Drop on a Vibrating Bath
Brandenbourger, Martin ULg; Vandewalle, Nicolas ULg; Dorbolo, Stéphane ULg

in Physical Review Letters (2016), 116

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See detailBurkholderia genome mining for nonribosomal peptide synthetases reveals a great potential for novel siderophores and lipopeptides synthesis
Esmaeel, Q.; Pupin, M.; Phuong Kieu, N. et al

in MicrobiologyOpen (2016), 5(3), 512-526

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See detailBRYONIA ALBA L. AND ECBALLIUM ELATERIUM (L.) A. RICH. - TWO RELATED SPECIES OF THE CUCURBITACEAE FAMILY WITH IMPORTANT PHARMACEUTICAL POTENTIAL
Ielciu, Irina-Ioana ULg; Frederich, Michel ULg; Tits, Monique ULg et al

in Farmacia (2016), 64(3), 323-332

The importance of the Cucurbitaceae family consists not only in the species that are widely known for various economically important human uses, but also in the species that have proven an important and ... [more ▼]

The importance of the Cucurbitaceae family consists not only in the species that are widely known for various economically important human uses, but also in the species that have proven an important and promising potential concerning their biological activities. Bryonia alba L. and Ecballium elaterium (L.) A. Rich. are two species belonging to this family, that are known since ancient times for their homeopathic or traditional use in the treatment of numerous disorders. There is clear evidence that links between the two species are not only related to family morphological characters, but also to a certain degree to the sexual system and, most importantly, to the active principle content or to potential medicinal uses. All these elements helped to include both species in the same tribe and may result in important reasons for heading future studies towards the elucidation of their complete phytochemical composition and mechanisms of the biological activities. The present study aims to review the existing scientific literature on the two species and to offer sufficient evidence in order to justify a most detailed study of their pharmaceutical potential. [less ▲]

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See detailLong term-cultured and cryopreserved primordial germ cells from various chicken breeds retain high proliferative potential and gonadal colonisation competency
Tonus, Céline ULg; Cloquette, Karine; Ectors, Fabien ULg et al

in Reproduction, Fertility and Development (2016), 28(5), 628-639

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See detailOld‐Age Employment and Hours of Work Trends: Empirical Analysis for Four European Countries
Jousten, Alain ULg; Perelman, Sergio ULg; Flawinne, Xavier ULg et al

in IZA Journal of European Labor Studies (2016)

FFor the last two decades, the increase of employment among individuals aged 50+ has been a policy objective on the European employment agenda. The present paper focuses on the case of Belgium, France ... [more ▼]

FFor the last two decades, the increase of employment among individuals aged 50+ has been a policy objective on the European employment agenda. The present paper focuses on the case of Belgium, France, Germany and The Netherlands over the period 1997—2011. First, we provide descriptive analysis of older workers’ employment using data from the European Union Labour Force Survey. Second, we use econometric techniques to explain the different employment and hours of work patterns for various sub-groups of older workers over time. We find evidence of catching up of older generation’s employment rates – with no rupture at the financial crisis in 2007. Third, we use microsimulation techniques to decompose the effects of structural changes, as well as extensive and intensive labor supply changes. [less ▲]

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See detailClarifying the Socio-Economic Dimensions of Agroecology: Between Principles and Practices
Dumont, Antoinette M.; Vanloqueren, Gaëtan; Stassart, Pierre M ULg et al

in Agroecology and Sustainable Food Systems (2016), 1(1), 24-47

AbstractThe concept of agroecology is being mobilized increasingly. However, its socio-economic dimensions receive little attention from academia. This study helps to clarify the socio-economic principles ... [more ▼]

AbstractThe concept of agroecology is being mobilized increasingly. However, its socio-economic dimensions receive little attention from academia. This study helps to clarify the socio-economic principles of agroecology by first identifying a list of principles in popular and scientific literature and, as a second step, by putting the principles to the test of a qualitative study of two Belgian organizations. Agribio is a grain cooperative, and Les Grosses L√©gumes is a network of consumers, farmers, and the members of an association set up to organize the production and distribution of vegetable boxes. Semi-directed interviews of the various actors linked to these organizations were conducted and then analyzed through an approach inspired by the convention theory in order to reveal the principles that the stakeholders have adopted. The main findings are then made explicit by analysis of four strong agreements (which concern the two organizations? marketing schemes, a Participatory Guarantee System set up by Les Grosses L√©gumes and Agribio?s flour mill). The two case studies show the gap that exists between the principles that describe the horizon of agroecology and the principles that are actually put into practice by the parties in the field through various transition pathways. [less ▲]

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See detailThe Concept of Risk Assessment and Being Unfit for Surgery.
Kolh, Philippe ULg; De Hert, S.; De Rango, P.

in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2016), 51(6), 857-66

The concept of risk assessment and the identification of surgical unfitness for vascular intervention is a particularly controversial issue today as the minimally invasive surgical population has ... [more ▼]

The concept of risk assessment and the identification of surgical unfitness for vascular intervention is a particularly controversial issue today as the minimally invasive surgical population has increased not only in volume but also in complexity (comorbidity profile) and age, requiring an improved pre-operative selection and definition of high risk. A practical step by step (three steps, two points for each) approach for surgical risk assessment is suggested in this review. As a general rule, the identification of a "high risk" patient for vascular surgery follows a step by step process where the risk is clearly defined, quantified (when too "high"?), and thereby stratified based on the procedure, the patient, and the hospital, with the aid of predictive risk scores. However, there is no standardized, updated, and objective definition for surgical unfitness today. The major gap in the current literature on the definition of high risk in vascular patients explains the lack of sound validated predictive systems and limited generalizability of risk scores in vascular surgery. In addition, the concept of fitness is an evolving tool and many traditional high risk criteria and definitions are no longer valid. Given the preventive purpose of most vascular procedures performed in elderly asymptomatic patients, the decision to pursue or withhold surgery requires realistic estimates not only regarding individual peri-operative mortality, but also life expectancy, healthcare priorities, and the patient's primary goals, such as prolongation of life versus maintenance of independence or symptom relief. The overall "frailty" and geriatric risk burden, such as cognitive, functional, social, and nutritional status, are variables that should be also included in the analyses for stratification of surgical risk in elderly vascular patients. [less ▲]

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See detailEfficacy and safety of hyaluronic acid in the management of osteoarthritis : Evidence from real-life setting trials and surveys.
Maheu, E.; Rannou, F.; Reginster, Jean-Yves ULg

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 28-33

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee osteoarthritis (OA) as second-line treatment in patients who remain symptomatic despite use of non-steroidal anti-inflammatory drugs (NSAIDs). This recommendation is based upon accumulating evidence that IA HA provides a significant benefit in knee OA. There is good evidence that IA HA injections reduce pain and increase function in knee OA, and the benefits are long-lasting as compared with IA corticosteroids. Evidence from real-life studies of repeat courses of IA HA demonstrates an improvement in pain or function lasting up to 40 months (12 months after the last injection cycle), a reduction in use of concomitant analgesia by up to 50%, and suggests that there may be a delay in the need for total knee replacement (TKR) of around 2 years. The clinical benefit of IA HA on knee OA may be 2-fold: (i) mechanical viscosupplementation of the joint (allowing lubrication and shock absorption) and (ii) the re-establishment of joint homeostasis through induction of endogenous HA production, which continues long after the exogenous injection has left the joint.The magnitude of the clinical effect may be different for different HA products, but this has not been proven so far and requires further investigation. IA HA injections are generally considered to be safe,although a slightly higher number of cases of local reactions and post-injection non-septic arthritis has been reported with high molecular weight cross-linked HAs. The use of IA HA in knee OA patients with mild–moderate disease, and for more severe patients wishing to delay TKR surgery,is recommended by the ESCEO taskforce. Further investigation into the OA patient types most likely to benefit from IA HA is warranted. Viscosupplementation with IA HA is a safe and effective component of the multi-modal management of knee OA. [less ▲]

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See detailCrop model improvement reduces the uncertainty of the response to temperature of multi-model ensembles
Maiorano, Andrea; Martre, Pierre; Asseng, Senthold et al

in Field Crops Research (2016), In press

o improve climate change impact estimates and to quantify their uncertainty, multi-model ensembles (MMEs) have been suggested. Model improvements can improve the accuracy of simulations and reduce the ... [more ▼]

o improve climate change impact estimates and to quantify their uncertainty, multi-model ensembles (MMEs) have been suggested. Model improvements can improve the accuracy of simulations and reduce the uncertainty of climate change impact assessments. Furthermore, they can reduce the number of models needed in a MME. Herein, 15 wheat growth models of a larger MME were improved through re-parameterization and/or incorporating or modifying heat stress effects on phenology, leaf growth and senescence, biomass growth, and grain number and size using detailed field experimental data from the USDA Hot Serial Cereal experiment (calibration data set). Simulation results from before and after model improvement were then evaluated with independent field experiments from a CIMMYT world-wide field trial network (evaluation data set). Model improvements decreased the variation (10th to 90th model ensemble percentile range) of grain yields simulated by the MME on average by 39% in the calibration data set and by 26% in the independent evaluation data set for crops grown in mean seasonal temperatures >24 °C. MME mean squared error in simulating grain yield decreased by 37%. A reduction in MME uncertainty range by 27% increased MME prediction skills by 47%. Results suggest that the mean level of variation observed in field experiments and used as a benchmark can be reached with half the number of models in the MME. Improving crop models is therefore important to increase the certainty of model-based impact assessments and allow more practical, i.e. smaller MMEs to be used effectively. [less ▲]

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See detail. Mass sensor utilising the mode-localisation effect in an electrostatically-coupled MEMS resonator pair fabricated using an SOI process
Wood, Graham; Chun, Zhao; Pu, Suan et al

in Microelectronic Engineering (2016), 159

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode ... [more ▼]

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode-localisation effect. It has been demonstrated that the shift in the amplitude ratio of the coupled-resonators at the in-phase mode frequency, in response to a mass change, is five orders of magnitude greater than the equivalent resonant frequency shift of a single resonator device. The device has been fabricated using a silicon-on-insulator (SOI) based process, which allows for high-yield and stiction-free fabrication. In addition, the design of the resonators has been created to have a larger surface area than previously reported designs, in order to facilitate future biological functionalisation. The mass sensitivity has been compared to current state-of-the-art mode-localised mass sensors and a 5.4 times increase in the amplitude ratio response to a given mass change has been demonstrated for the device in this work. [less ▲]

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See detailIn silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market.
Geris, Liesbet ULg; Guyot, Y.; Schrooten, J. et al

in Interface focus (2016), 6(2), 20150105

The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as ... [more ▼]

The cell therapy market is a highly volatile one, due to the use of disruptive technologies, the current economic situation and the small size of the market. In such a market, companies as well as academic research institutes are in need of tools to advance their understanding and, at the same time, reduce their R&D costs, increase product quality and productivity, and reduce the time to market. An additional difficulty is the regulatory path that needs to be followed, which is challenging in the case of cell-based therapeutic products and should rely on the implementation of quality by design (QbD) principles. In silico modelling is a tool that allows the above-mentioned challenges to be addressed in the field of regenerative medicine. This review discusses such in silico models and focuses more specifically on the bioprocess. Three (clusters of) examples related to this subject are discussed. The first example comes from the pharmaceutical engineering field where QbD principles and their implementation through the use of in silico models are both a regulatory and economic necessity. The second example is related to the production of red blood cells. The described in silico model is mainly used to investigate the manufacturing process of the cell-therapeutic product, and pays special attention to the economic viability of the process. Finally, we describe the set-up of a model capturing essential events in the development of a tissue-engineered combination product in the context of bone tissue engineering. For each of the examples, a short introduction to some economic aspects is given, followed by a description of the in silico tool or tools that have been developed to allow the implementation of QbD principles and optimal design. [less ▲]

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See detailElectrophoretic deposition of hydroxyapatite and hydroxyapatite– alginate on rapid prototyped 3D Ti6Al4V scaffolds
Ozhukil Kollath, Vinayaraj; Chen, Qiang; Mullens, Steven et al

in Journal of Materials Science (2016), 51

The advantage of using bioceramic particles coated on porous three-dimensional structures is still unexplored in the purpose of improving the osteoinduction of hybrid metallic scaffold implants in vivo ... [more ▼]

The advantage of using bioceramic particles coated on porous three-dimensional structures is still unexplored in the purpose of improving the osteoinduction of hybrid metallic scaffold implants in vivo. In this study, we evaluate electrophoretic deposition (EPD) to coat porous Ti6Al4V scaffolds with hydroxyapatite (HA). Scaffolds were shaped in different open structures with a horizontal shift in fiber stacking. They were produced using three-dimensional fiber deposition method and were coated by EPD with HA powder (d10 = 1.7, d50 = 5.7 and d90 = 18 lm) suspended in ethanol or butanol at different concentration, DC voltage, and time. A composite HA–alginate was also used to coat the scaffolds. Alginate was used as a binder, and the coating properties (homogeneity, thickness, cracks, continuity, etc.) were compared to coatings obtained from pure HA suspensions. Voltage and time of deposition effects were studied between 10 and 140 V and 10 and 120 s, respectively. Coating thickness and density with respect to the depth of the porous structure were studied by observing cross sections using scanning electron microscopy and image processing analysis. HA–alginate combination resulted in a homogeneous and deeper dense layer of HA. This work also points to the characteristics of HA–alginate composite as a superior alternative to pure HA coating which needs an appropriate thermal treatment for adequate substrate adhesion. [less ▲]

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See detailBovine noroviruses: A missing component of calf diarrhoea diagnosis
Di Felice, Elisabetta; Mauroy, Axel ULg; Dal Pozzo, Fabiana ULg et al

in Veterinary Journal (2016), 207

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See detailParsimonious time series clustering using P-splines
Iorio, Carmela; Frasso, Gianluca ULg; D’Ambrosio, Antonio et al

in Expert Systems with Applications (2016)

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available ... [more ▼]

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available observations. The measured time series can also be very noisy and sparse and an appropriate model describing them can be hard to define. We propose to model the observed measurements by using P-spline smoothers and then to cluster the functional objects as summarized by the optimal spline coefficients. According to the characteristics of the observed measurements, our proposal can be combined with any suitable clustering method. In this paper we provide applications based on non-hierarchical clustering algorithms. We evaluate the accuracy and the efficiency of our proposal by simulations and by analyzing two real data examples. [less ▲]

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See detailObservation en bref
Onclin, François ULg

in Aménagement - Environnement (2016)

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See detailCompeting effects of volume change and water uptake on the water retention behaviour of a compacted MX-80 bentonite/sand mixture
Gatabin, Claude; Talandier, Jean; Collin, Frédéric ULg et al

in Applied Clay Science (2016), 121-122

Bentonite-based materials have been studied as potential barriers for the geological disposal of radioactive waste. In this context, the hydro-mechanical behaviour of the engineered barrier is first ... [more ▼]

Bentonite-based materials have been studied as potential barriers for the geological disposal of radioactive waste. In this context, the hydro-mechanical behaviour of the engineered barrier is first characterized by free swelling conditions (as a consequence of the progressive filling of technological gaps) followed by constant volume conditions. This paper presents an experimental study conducted in order to characterize the water retention behaviour of a compacted MX-80 bentonite/sand mixture. The water retention properties upon wetting were investigated under both free swelling and constant volume conditions. In the high suction range, the water content was not influenced by the imposed volume constraints. On the contrary, swelling significantly affected the water retention behaviour at low suctions, and the quantity of water stored was higher under free swelling conditions than it was under prevented swelling. In this case, competing effects between bentonite swelling and water uptake did not lead to an increase of the degree of saturation upon wetting, as it was observed for samples wetted under constant volume conditions. The influence of the very strong hydro-mechanical coupling is further discussed. [less ▲]

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See detailA comprehensive density functional theory study of the key role of fluorination and dual hydrogen bonding in the activation of the epoxide/CO2 coupling by fluorinated alcohols
Alves, Margot ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

in RSC Advances (2016), 6(43), 36327-36335

The activation mechanism of the CO2/propylene oxide coupling catalysed by a bicomponent organocatalyst combining the use of TBABr with (multi)phenolic or fluorinated hydrogen bond donors (HBDs) was ... [more ▼]

The activation mechanism of the CO2/propylene oxide coupling catalysed by a bicomponent organocatalyst combining the use of TBABr with (multi)phenolic or fluorinated hydrogen bond donors (HBDs) was investigated using the Density Functional Theory (DFT). Thus, it was shown that increasing the number of electron withdrawing trifluoromethyl substituents in HBDs strengthens their proton donor capability and allows a better stabilization by hydrogen bonding of the intermediates and transition states. In addition, the high efficiency of fluorinated monoalcohol activators is related to a dual hydrogen bonding mechanism by two fluorinated molecules that cooperatively contribute to the CO2/propylene oxide coupling. [less ▲]

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See detailCorrelation between ethanol behavioral sensitization and midbrain dopamine neuron reactivity to ethanol
Didone, Vincent ULg; Masson, Sébastien; Quoilin, Caroline et al

in Addiction Biology (2016), 21(2), 387-396

Repeated ethanol injections lead to a sensitization of its stimulant effects in mice. Some recent results argue against a role for ventral tegmental area (VTA) dopamine neurons in ethanol behavioral ... [more ▼]

Repeated ethanol injections lead to a sensitization of its stimulant effects in mice. Some recent results argue against a role for ventral tegmental area (VTA) dopamine neurons in ethanol behavioral sensitization. The aim of the present study was to test whether in vivo ethanol locomotor sensitization correlates with changes in either basal- or ethanol evoked firing rates of dopamine neurons in vitro. Female Swiss mice were daily injected with 2.5 g/kg ethanol (or saline in the control group) for 7 days and their locomotor activity was recorded. At the end of the sensitization procedure, extracellular recordings were made from dopaminergic neurons in midbrain slices from these mice. Significantly higher spontaneous basal firing rates of dopamine neurons were recorded in ethanol-sensitized mice relative to control mice, but without correlations with the behavioral effects. The superfusion of sulpiride, a dopamine D2 antagonist, induced a stronger increase of dopamine neuron firing rates in ethanol-sensitized mice. This shows that the D2 feedback in dopamine neurons is preserved after chronic ethanol administration and argues against a reduced D2 feedback as an explanation for the increased dopamine neuron basal firing rates in ethanol-sensitized mice. Finally, ethanol superfusion (10–100 mM) significantly increased the firing rates of dopamine neurons and this effect was of higher magnitude in ethanol-sensitized mice. Furthermore, there were significant correlations between such a sensitization of dopamine neuron activity and ethanol behavioral sensitization. These results support the hypothesis that changes in brain dopamine neuron activity contribute to the behavioral sensitization of the stimulant effects of ethanol. [less ▲]

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See detailIs the Nociception Coma Scale-Revised a Useful Clinical Tool for Managing Pain in Patients with Disorders of Consciousness?
Chatelle, Camille ULg; De Val, Marie Daniele; Catano, Antonio et al

in The Clinical journal of pain (2016)

OBJECTIVES: Our objective was to assess the clinical interest of the Nociception Coma Scale Revised (NCS-R) in pain management of patients with disorders of consciousness. METHODS: Thirty-nine patients ... [more ▼]

OBJECTIVES: Our objective was to assess the clinical interest of the Nociception Coma Scale Revised (NCS-R) in pain management of patients with disorders of consciousness. METHODS: Thirty-nine patients with potential painful conditions (e.g., due to fractures, decubitus ulcers or spasticity) were assessed during nursing cares before and after the administration of an analgesic treatment tailored to each patient's clinical status. In addition to the NCS-R, the Glasgow Coma Scale (GCS) was used before and during treatment in order to observe fluctuations in consciousness. Twenty-three of them had no analgesic treatment prior to the assessment whereas the analgesic treatment has been adapted in the other 16 patients. We performed non-parametric Wilcoxon tests to investigate the difference in the NCS-R and GCS total scores but also in the NCS-R subscores before versus during treatment. The effect of the level of consciousness and the etiology were assessed using a U Mann Whitney. RESULTS: NCS-R total scores were statistically lower during treatment when compared to the scores obtained before treatment. We also found that the motor, verbal and facial expression subscores were lower during treatment than before treatment. On the other hand, we found no difference between the GCS total scores obtained before versus during treatment. DISCUSSION: Our results suggest that the NCS-R is an interesting clinical tool for pain management. Besides, this tool seems useful when a balance is needed between reduced pain and preserved level of consciousness in patients with disorders of consciousness. [less ▲]

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See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (première partie)
Léonard, Laura ULg; Caprasse, Olivier; Dieux, Xavier et al

in Revue Critique de Jurisprudence Belge [= RCJB] (2016), (1),

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See detailIconic turn et critique du paradigme langagier
Hagelstein, Maud ULg

in Bulletin d'Analyse Phénoménologique (2016), 12 (2016)(2),

Comment appréhender le problème de la légalité des significations dans le champ non verbal du visuel ? Tel est l’exercice auquel s’essaie le théoricien de l’image allemand Gottfried Boehm, soucieux de ... [more ▼]

Comment appréhender le problème de la légalité des significations dans le champ non verbal du visuel ? Tel est l’exercice auquel s’essaie le théoricien de l’image allemand Gottfried Boehm, soucieux de dégager les principes formels structurant l’émergence de significations dans le domaine du visuel, tout en tenant à distance l’usage de la grammaire prédicative pour la compréhension des images. Sa proposition s’inscrit dans le cadre des débats autour de ce que l’on appelle — dans le domaine de la théorie de l’image actuelle — l’iconic turn (le « tournant iconique » / ikonische Wendung). À bien des égards, l’iconic turn est lié à une réflexion large sur l’héritage de l’iconologie, cette discipline d’interprétation des images inaugurée en 1912 par le théoricien de l’art Aby Warburg (1866-1929), nourrie par la philosophie des formes symboliques de Ernst Cassirer (1874-1945), et systématisée par Erwin Panofsky (1892-1968) dans ses Essais d’iconologie (1939), notamment1. Visant l’interprétation du contenu symbolique des images, la méthode iconologique concevait l’art comme l’un des domaines essentiels de production de sens, une « forme symbolique » privilégiée, pour reprendre la terminologie cassirérienne2. Le célèbre tableau synthétique repris en introduction aux Essais d’iconologie montre comment procède l’iconologie, par dégagement progressif de couches de significations. S’il a construit sa méthode en dialogue avec la philosophie, Panofsky n’a pas pour autant intégré au cahier des charges de l’iconologie l’ambition de dégager systématiquement les principes formels conditionnant la possibilité même de la signification — raison pour laquelle cette discipline n’est pas à proprement parler philosophique. L’iconologie est exégétique ; elle offre les outils nécessaires à une interprétation précise du contenu des œuvres. Table des matières 1. Changement de paradigme : le tournant iconique 2. La différence iconique : une logique des contrastes 3. L’image montre la monstration 4. Un affranchissement relatif Conclusion [less ▲]

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See detailA quadratic contact element passing the patch test
Nguyen, Duc-Tué; Rauchs, Gast; Ponthot, Jean-Philippe ULg

in Key Engineering Materials [=KEM] (2016), 681

For the two dimensional contact modeling, the standard node-to-segment quadratic contact elements are known to exhibit oscillations of the contact pressure. This situation is particularly critical when ... [more ▼]

For the two dimensional contact modeling, the standard node-to-segment quadratic contact elements are known to exhibit oscillations of the contact pressure. This situation is particularly critical when using the penalty method with a high penalty parameter because the amplitude of the oscillations increase with increasing penalty parameter. The aim of this article is to present a method for removing the oscillations of contact pressure observed while using quadratic contact element. For this purpose, the nodal forces at the slave and at the master nodes need to be evaluated appropriately. One possibility is to develop a suitable procedure for computing the nodal forces. In that sake, we selected the approach first proposed in [35] in an appropriate manner. After presenting the improved quadratic contact element, some numerical examples are illustrated in this paper to compare the standard quadratic node-to-segment element with the proposed element. The examples show that the proposed element can strongly reduce the oscillating contact pressure for both plane and curved contact surfaces. [less ▲]

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See detailDetecting urban road network accessibility problems using taxi GPS data
Cui, JianXun; Liu, Feng; Janssens, Davy et al

in Journal of Transport Geography (2016), 51

Urban population growth and economic development have led to the creation of new communities, jobs and services at places where the existing road network might not cover or efficiently handle traffic ... [more ▼]

Urban population growth and economic development have led to the creation of new communities, jobs and services at places where the existing road network might not cover or efficiently handle traffic. This generates isolated pockets of areas which are difficult to reach through the transport system. To address this accessibility problem, we have developed a novel approach to systematically examine the current urban land use and road network conditions as well as to identify poorly connected regions, using GPS data collected from taxis. This method is composed of four major steps. First, city-wide passenger travel demand patterns and travel times are modeled based on GPS trajectories. Upon this model, high density residential regions are then identified, and measures to assess accessibility of each of these places are developed. Next, the regions with the lowest level of accessibility among all the residential areas are detected, and finally the detected regions are further examined and specific transport situations are analyzed. By applying the proposed method to the Chinese city of Harbin, we have identified 20 regions that have the lowest level of accessibility by car among all the identified residential areas. A serious reachability problem to petrol stations has also been discovered, in which drivers from 92.6% of the residential areas have to travel longer than 30 min to refill their cars. Furthermore, the comparison against a baseline model reveals the capacity of the derived measures in accounting for the actual travel routes under divergent traffic conditions. The experimental results demonstrate the potential and effectiveness of the proposed method in detecting car-based accessibility problems, contributing towards the development of urban road networks into a system that has better reachability and more reduced inequity. [less ▲]

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See detailEffects of microgravity simulation on zebrafish transcriptomes and bone physiology; exposure starting at 5 days post-fertilization.
Aceto, Jessica ULg; Nourizadeh-Lillabadi, Rasoul; Bradamante, Silvia et al

in NPJ Microgravity (2016), 2

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See detailDegradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2).
Butler, Georgina S.; Connor, Andrea R.; Sounni, Nor Eddine ULg et al

in Matrix Biology (2016)

Members of the CCN family of matricellular proteins are cytokines linking cells to the extracellular matrix. We report that CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14 (membrane-type 1 ... [more ▼]

Members of the CCN family of matricellular proteins are cytokines linking cells to the extracellular matrix. We report that CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14 (membrane-type 1-matrix metalloproteinase, MT1-MMP) that we identified using MMP14 "inactive catalytic domain capture" (ICDC) as a yeast two-hybrid protease substrate trapping platform in parallel with degradomics mass spectrometry screens for MMP14 substrates. CCN3 and CCN5, previously unknown substrates of MMPs, were biochemically validated as substrates of MMP14 and other MMPs in vitro-CCN5 was processed in the variable region by MMP14 and MMP2, as well as by MMP1, 3, 7, 8, 9 and 15. CCN1, 2 and 3 are proangiogenic factors yet we found novel opposing activity of CCN5 that was potently antiangiogenic in an aortic ring vessel outgrowth model. MMP14, a known regulator of angiogenesis, cleaved CCN5 and abrogated the angiostatic activity. CCN3 was also processed in the variable region by MMP14 and MMP2, and by MMP1, 8 and 9. In addition to the previously reported cleavages of CCN1 and CCN2 by several MMPs we found that MMPs 8, 9, and 1 process CCN1, and MMP8 and MMP9 also process CCN2. Thus, our study reveals additional and pervasive family-wide processing of CCN matricellular proteins/cytokines by MMPs. Furthermore, CCN5 cleavage by proangiogenic MMPs results in removal of an angiogenic brake held by CCN5. This highlights the importance of thorough dissection of MMP substrates that is needed to reveal higher-level control mechanisms beyond type IV collagen and other extracellular matrix protein remodelling in angiogenesis. SUMMARY: We find CCN family member cleavage by MMPs is more pervasive than previously reported and includes CCN3 (Nov) and CCN5 (WISP2). CCN5 is a novel antiangiogenic factor, whose function is abrogated by proangiogenic MMP cleavage. By processing CCN proteins, MMPs regulate cell responses angiogenesis in connective tissues. [less ▲]

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See detailMultimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model
NCHIMI LONGANG, Alain ULg; Courtois, Audrey ULg; EL HACHEMI, Mounia ULg et al

in European Radiology (2016), 26

Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction ... [more ▼]

Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results All of the following significantly increased with time post-induction (p < 0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. [less ▲]

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See detailL’utilisation de l’hydrolyse enzymatique pour la production de nanocellulose dans une stratégie de bioraffinage forestier intégré
Bombeck, Pierre-Louis ULg; Hebert, Jacques ULg; Richel, Aurore ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(1), 94-103

Introduction. In a world that seeks to break free from petrochemicals, the concept of forest biomass biorefinery is increasingly being studied as a way to maximize the value of the components of this ... [more ▼]

Introduction. In a world that seeks to break free from petrochemicals, the concept of forest biomass biorefinery is increasingly being studied as a way to maximize the value of the components of this biomass. Due to the high added value expected when transforming cellulose fibers into nanocellulose, this technology is highly attractive to the pulp and paper industrial world. Literature. The concept of integrated forest biorefinery is to adapt existing pulp mills so as to maximize the value of the co-products. Through the use of various methods, two types of nanocellulose may be obtained from the cellulose in the pulp. Due to its production of valuable byproducts, enzymatic hydrolysis is an interesting method to use for this purpose, but it must be combined with mechanical post-treatments. The production of nanocellulose from chemical pulp takes place in the final step of pulp production, and could be implemented without modifying the existing mills. The economic viability of this mode of production and the potential market size are the subject of recent studies that appear encouraging. Conclusions. Nanocellulose is a promising biomaterial whose field of application continues to grow. Cellulose in wood pulp can be used as a raw material for the production of nanocellulose using enzymatic pre-treatments that generate valuable co-products. This process can be integrated into a conventional chemical pulp mill and constitutes a broadening of the products available to the pulp and paper industry. [less ▲]

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See detailAn inversion method for cometary atmospheres
Hubert, Benoît ULg; Opitom, Cyrielle ULg; Hutsemekers, Damien ULg et al

in Icarus (2016)

Remote observation of cometary atmospheres produces a measurement of the cometary emissions integrated along the line of sight. This integration is the so-called Abel transform of the local emission rate ... [more ▼]

Remote observation of cometary atmospheres produces a measurement of the cometary emissions integrated along the line of sight. This integration is the so-called Abel transform of the local emission rate. The observation is generally interpreted under the hypothesis of spherical symmetry of the coma. Under that hypothesis, the Abel transform can be inverted. We derive a numerical inversion method adapted to cometary atmospheres using both analytical results and least squares fitting techniques. This method, derived under the usual hypothesis of spherical symmetry, allows us to retrieve the radial distribution of the emission rate of any unabsorbed emission, which is the fundamental, physically meaningful quantity governing the observation. A Tikhonov regularization technique is also applied to reduce the possibly deleterious effects of the noise present in the observation and to warrant that the problem remains well posed. Standard error propagation techniques are included in order to estimate the uncertainties affecting the retrieved emission rate. Several theoretical tests of the inversion techniques are carried out to show its validity and robustness. In particular, we show that the Abel inversion of real data is only weakly sensitive to an offset applied to the input flux, which implies that the method, applied to the study of a cometary atmosphere, is only weakly dependent on uncertainties on the sky background which has to be subtracted from the raw observations of the coma. We apply the method to observations of three different comets observed using the TRAPPIST telescope: 103P/ Hartley 2, F6/ Lemmon and A1/ Siding Spring. We show that the method retrieves realistic emission rates, and that characteristic lengths and production rates can be derived from the emission rate for both CN and C2 molecules. We show that the retrieved characteristic lengths can differ from those obtained from a direct least squares fitting over the observed flux of radiation, and that discrepancies can be reconciled for by correcting this flux by an offset (to which the inverse Abel transform is nearly not sensitive). The A1/Siding Spring observations were obtained very shortly after the comet produced an outburst, and we show that the emission rate derived from the observed flux of CN emission at 387 nm and from the C2 emission at 514.1 nm both present an easily-identifiable shoulder that corresponds to the separation between pre- and post-outburst gas. As a general result, we show that diagnosing properties and features of the coma using the emission rate is easier than directly using the observed flux, because the Abel transform produces a smoothing that blurs the signatures left by features present in the coma. We also determine the parameters of a Haser model fitting the inverted data and fitting the line-of-sight integrated observation, for which we provide the exact analytical expression of the line-of-sight integration of the Haser model. [less ▲]

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See detailIdentification of specific bovine blood biomarkers with a non-targeted approach using HPLC ESI tandem mass spectrometry
Lecrenier, Marie-Caroline ULg; Marbaix, Hélène; Dieu, Marc et al

in Food Chemistry (2016), 213

Animal by-products are valuable protein sources in animal nutrition. Among them are blood products and blood meal, which are used as high-quality material for their beneficial effects on growth and health ... [more ▼]

Animal by-products are valuable protein sources in animal nutrition. Among them are blood products and blood meal, which are used as high-quality material for their beneficial effects on growth and health. Within the framework of the feed ban relaxation, the development of complementary methods in order to refine the identification of processed animal proteins remains challenging. The aim of this study was to identify specific biomarkers that would allow the detection of bovine blood products and processed animal proteins using tandem mass spectrometry. Seventeen biomarkers were identified: nine peptides for bovine plasma powder; seven peptides for bovine haemoglobin powder, including six peptides for bovine blood meal; and one peptide for porcine blood. They were not detected in several commercial compound feed or feed materials, such as blood by-products of other animal origins, milk-derived products and fish meal. These biomarkers could be used for developing a species-specific and blood-specific detection method. [less ▲]

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See detailCultural Practices Shaping Zoonotic Diseases Surveillance: The Case of Highly Pathogenic Avian Influenza and Thailand Native Chicken Farmers.
Delabouglise, Alexis; Antoine-Moussiaux, Nicolas ULg; Tatong, D. et al

in Transboundary and Emerging Diseases (2016)

Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population. Eval- uating the acceptability of passive ... [more ▼]

Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population. Eval- uating the acceptability of passive surveillance and its economic, social and cul- tural determinants appears a critical step for improving it. A participatory rural appraisal was implemented in a rural subdistrict of Thailand. Focus group inter- views were used to identify sanitary risks perceived by native chicken farmers and describe the structure of their value chain. Qualitative individual interviews with a large diversity of actors enabled to identify perceived costs and benefits associ- ated with the reporting of HPAI suspicions to sanitary authorities. Besides, flows of information on HPAI suspected cases were assessed using network analysis, based on data collected through individual questionnaires. Results show that the presence of cockfighting activities in the area negatively affected the willingness of all chicken farmers and other actors to report suspected HPAI cases. The high financial and affective value of fighting cocks contradicted the HPAI control pol- icy based on mass culling. However, the importance of product quality in the native chicken meat value chain and the free veterinary services and products delivered by veterinary officers had a positive impact on suspected case reporting. Besides, cockfighting practitioners had a significantly higher centrality than other actors in the information network and they facilitated the spatial diffusion of information. Social ties built in cockfighting activities and the shared purpose of protecting valuable cocks were at the basis of the diffusion of information and the informal collective management of diseases. Building bridges with this informal network would greatly improve the effectiveness of passive surveillance. [less ▲]

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See detailWhat Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies.
Moscarelli, Marco; Fattouch, Khalil; Casula, Roberto et al

in The Annals of thoracic surgery (2016)

BACKGROUND: Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. METHODS: A ... [more ▼]

BACKGROUND: Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. METHODS: A systematic literature review identified eight studies of which seven fulfilled criteria for meta-analysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long-term follow-up. RESULTS: Minimally invasive mitral valve surgery conferred comparable early mortality to standard sternotomy (p = 0.19); it was also associated with a lower number of units of blood transfused (weighted mean difference, -1.93; 95% confidence interval [CI], -3.04 to -0.82; p = 0.0006) and atrial fibrillation rate (odds ratio, 0.49; 95% CI, 0.32 to 0.74; p = 0.0007); however, cardiopulmonary bypass time was longer (weighted mean difference, 20.88; 95% CI, -1.90 to 43.65; p = 0.07). There was no difference in terms of valve repair rate (odds ratio, 1.51; 95% CI, 0.89 to 2.54; p = 0.12), and the incidence of stroke was significantly lower in the high-quality analysis with no heterogeneity (odds ratio, 0.35; 95% CI, 0.15 to 0.82; p = 0.02; chi2, 1.67; I2, 0%; p = 0.43). CONCLUSIONS: Minimally invasive mitral valve surgery is a safe and comparable alternative to standard sternotomy in patients at high risk, with similar early mortality and repair rate and better postoperative outcomes, although a longer cardiopulmonary bypass time is required. [less ▲]

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See detailFabrication and characterization of polymer membranes with integrated arrays of high performance micro-magnets
Roy, D. L.; Shaw, Gorky ULg; Haettel, R. et al

in Materials Today Communications (2016), 6

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See detailImmiscible iron- and silica-rich liquids in the Upper Zone of the Bushveld Complex
Fischer, Lennart A.; Wang, Meng; Charlier, Bernard ULg et al

in Earth and Planetary Science Letters (2016), 443

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See detailQuantitative assessment of mouse mammary gland morphology using automated digital image processing and TEB detection.
Blacher, Silvia ULg; Gérard, Céline ULg; Gallez, Anne ULg et al

in Endocrinology (2016)

The assessment of rodent mammary gland morphology is largely used to study the molecular mechanisms driving breast development and to analyze the impact of various endocrine disruptors with putative ... [more ▼]

The assessment of rodent mammary gland morphology is largely used to study the molecular mechanisms driving breast development and to analyze the impact of various endocrine disruptors with putative pathological implications. In this work, we propose a methodology relying on fully automated digital image analysis methods including image processing and quantification of the whole ductal tree and of the terminal end buds (TEB) as well. It allows to accurately and objectively measure both growth parameters and fine morphological glandular structures. Mammary gland elongation was characterized by two parameters: the length and the epithelial area of the ductal tree. Ductal tree fine structures were characterized by: 1) branch end-point density, 2) branching density and 3) branch length distribution. The proposed methodology was compared to quantification methods classically used in the literature. This procedure can be transposed to several software and thus largely used by scientists studying rodent mammary gland morphology. [less ▲]

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See detailEnvironmental Control of Root System Biology.
Rellan-Alvarez, Ruben; Lobet, Guillaume ULg; Dinneny, Jose R.

in Annual review of plant biology (2016)

The plant root system traverses one of the most complex environments on earth. Understanding how roots support plant life on land requires knowing how soil properties affect the availability of nutrients ... [more ▼]

The plant root system traverses one of the most complex environments on earth. Understanding how roots support plant life on land requires knowing how soil properties affect the availability of nutrients and water and how roots manipulate the soil environment to optimize acquisition of these resources. Imaging of roots in soil allows the integrated analysis and modeling of environmental interactions occurring at micro- to macroscales. Advances in phenotyping of root systems is driving innovation in cross-platformcompatible methods for data analysis. Root systems acclimate to the environment through architectural changes that act at the root-type level as well as through tissue-specific changes that affect the metabolic needs of the root and the efficiency of nutrient uptake. A molecular understanding of the signaling mechanisms that guide local and systemic signaling is providing insight into the regulatory logic of environmental responses and has identified points where crosstalk between pathways occurs. Expected final online publication date for the Annual Review of Plant Biology Volume 67 is April 29, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. [less ▲]

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See detailRecommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, Jean-Yves ULg; Cooper, Cyrus; Rizzoli, René et al

in Aging Clinical and Experimental Research (2016), 28(1), 47-58

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a ... [more ▼]

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities. Methods: A multidisciplinary expert working group was hosted by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, which reviewed and discussed the recent literature from a perspective of clinical experience and guideline development. Relevant parallels were drawn from the development of definition of osteoporosis as a disease and clinical assessment of pharmaceutical treatments for that indication. Results A case-finding decision tree is briefly reviewed with a discussion of recent prevalence estimations of different relevant threshold values. The selection criteria for patients in regulatory studies are discussed according to the aims of the investigation (sarcopenia prevention or treatment) and the stage of project development. The possible endpoints of such studies are reviewed and a pleais made for the establishment of a core outcome set to be used in all clinical trials of sarcopenia. Conclusions : The current lack of guidelines for the assessment of new therapeutic treatments for sarcopenia could potentially hinder the delivery of effective medicines to patients at risk. [less ▲]

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See detailInvestigation on possible transmission of monkeys' Plasmodium to human in a populations living in the equatorial rainforest of the Democratic republic of Congo
MVUMBI, Dieudonné; BOBANGA, Thierry; UMESUMBU, Solange et al

in International Journal for Parasitology: parasites and wild life (2016), 5

Plasmodiums are protozoa that may infect various hosts. Only five species are now recognized as naturally parasitizing humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ... [more ▼]

Plasmodiums are protozoa that may infect various hosts. Only five species are now recognized as naturally parasitizing humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. This fifth species, P. knowlesi, previously identified as naturally parasitizing the monkey Macaca fascicularis, has been microscopically confused for a long time with P. malariae or P. falciparum and it was not possible to correctly differentiate them until the advent of molecular biology. To date, natural human infections with P. knowlesi only occur in Southeast Asia and a similar phenomenon of natural transmission of simian plasmodium to humans has not been reported elsewhere. This study was conducted to investigate a possible transmission of African small monkey's plasmodium to humans in populations living near the rainforest of the Democratic Republic of Congo (DRC) where several species of non-human primates are living. Two successive real-time PCRs were identified in the literature and used in combination for purpose. Only P. falciparum was found in this study. However, studies with larger samples and with more advanced techniques should be conducted. [less ▲]

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See detailCharacterization of saccharides released during an in vitro pepsin-pancreatin digestion of corn flour using HPAEC-PAD
Odjo, Djosse Psijus Sylvanus ULg; Bera, François ULg; Jacquet, Nicolas ULg et al

in Stärke = Starch (2016), 68

Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric ... [more ▼]

Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric detector (HPAEC-PAD) and two colorimetric approaches (glucose oxidase/ peroxidase assay and the 3,5-dinitrosalicylic acid assay). HPAEC-PAD revealed five major saccharides as the result of in vitro pepsin-pancreatin digestion of corn grain: glucose, isomaltose, maltose, maltotriose, and glucosyl-maltotriose. Concentrations of glucose released as measured by the three methods assessed are similar when the in vitro pepsin-pancreatin digestion is followed by post incubation with amyloglucosidase. This post incubation unfortunately leads to a loss of information about the degree of polymerization of oligosaccharides that can impact their absorption through intestinal tract. HPAEC-PAD gives both qualitative and quantitative information and then seems more suitable for a nutritional appreciation of the digestion of starchy feedstuffs. [less ▲]

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See detailAn acceleration sensing method based on the mode localization of weakly coupled resonators
Zhang, H.M.; Yuan, W.Z.; Li, B.Y. et al

in Journal of Microelectromechanical Systems (2016), 25(2), 286-296

Abstract—This paper reports an acceleration sensing method based on two weakly coupled resonators (WCRs) using the phenomenon of mode localization. When acceleration acts on the proof masses, differential ... [more ▼]

Abstract—This paper reports an acceleration sensing method based on two weakly coupled resonators (WCRs) using the phenomenon of mode localization. When acceleration acts on the proof masses, differential electrostatic stiffness perturbations will be applied to the WCRs, leading to mode localization, and thus, mode shape changes. Therefore, acceleration can be sensed by measuring the amplitude ratio shift. The proposed mode localization with the differential perturbation method leads to a sensitivity enhancement of a factor of 2 than the common single perturbation method. The theoretical model of the sensitivity, bandwidth, and linearity of the accelerometer is established and verified. The measured relative shift in amplitude ratio (∼312162 ppm/g) is 302 times higher than the shift in resonance frequency (∼1035 ppm/g) within the measurement range of ±1g. The measured resolution based on the amplitude ratio is 0.619 mg and the nonlinearity is ∼3.5% in the open-loop measurement operation. [less ▲]

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See detailAccelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates
Raibaut, Laurent; Cargoët, Marine; Ollivier, Nathalie et al

in Chemical Science (2016)

Given the potential of peptide selenoesters for protein total synthesis and the paucity of methods for the synthesis of these sensitive peptide derivatives, we sought to explore the usefulness of the bis ... [more ▼]

Given the potential of peptide selenoesters for protein total synthesis and the paucity of methods for the synthesis of these sensitive peptide derivatives, we sought to explore the usefulness of the bis(2-selenylethyl)amido (SeEA) group, i.e. the selenium analog of the bis(2-sulfanylethyl)amido (SEA) group, for accelerating peptide bond formation. A chemoselective exchange process operating in water was devised for converting SEA peptides into the SeEA ones. Kinetic studies show that SeEA ligation, which relies on an initial N,Se-acyl shift process, proceeds significantly faster than SEA ligation. This property enabled the design of a kinetically controlled three peptide segment assembly process based on the sequential use of SeEA and SEA ligation reactions. The method was validated by the total synthesis of hepatocyte growth factor K1 (85 AA) and biotinylated NK1 (180 AA) domains [less ▲]

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See detailGuiana Dolphins (Sotalia guianensis) and DR-CALUX for Screening Coastal Brazilian Environments for Dioxins and Related Compounds
Dorneles, Paulo; Lailson-Brito, Jose; Bisi, Tatiana et al

in Archives of Environmental Contamination & Toxicology (2016)

Guiana dolphin is the top predator of highest toxicological concern in Brazil and many studies on levels of persistent, bioaccumulative, and toxicant (PBT) pollutants have been performed on the species ... [more ▼]

Guiana dolphin is the top predator of highest toxicological concern in Brazil and many studies on levels of persistent, bioaccumulative, and toxicant (PBT) pollutants have been performed on the species. However, due to high costs of the analyses, only one investigation comprised the determination of dioxins and related compounds (DRCs) in Guiana dolphin tissues. The dioxin responsive-chemically activated luciferase gene expression (DR-CALUX ) cell bioassay was used in the present study for the analyses of hepatic samples from 28 male Guiana dolphins in order to screen estuarine environments for DRCs, comprising three regions (Northeastern, Southeastern, and Southern) and four states [Parana´ (PR), Rio de Janeiro (RJ), Espı´rito Santo (ES), and Ceara´ (CE)] of Brazil. High bioanalytical equivalent (BEQ) concentrations [dioxins (pg BEQ/g lipid)] were found, varying from 1.94 to 15.6 pg BEQ/g. A significant negative correlation between BEQ concentrations and total length was found in Guiana dolphins from Brazil (all analysed dolphins). This pattern also was verified for RJ state, pointing to (1) chemically induced developmental disruption or to (2) increasing efficiency of the detoxifying activity with the growth of the animal. Comparison was performed with literature data and significantly higher BEQ levels were found in Brazilian Guiana dolphins than in those reported for North Sea harbour porpoises. Higher levels were found in Southeastern (the most PBT-contaminated area of the country) than in Southern region. However, it is not possible to affirm that Guiana dolphins are more contaminated by DRCs in SE than in S region, because individuals were lengthier in S than in SE region. Our results seem to have mirrored dolphin exposure to PCBs in Brazil according to the literature. Further studies are required for investigating the hypotheses 1 and 2 mentioned above. [less ▲]

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See detailNumerical and experimental study of the glass flow and heat transfer in the continuous glass fiber drawing process
Chouffart, Quentin ULg; Simon, Philippe; Terrapon, Vincent ULg

in Journal of Materials Processing Technology (2016)

The manufacturing process of glass fibers used for the reinforcement of composite materials consistsin drawing a free jet of a molten glass at high temperature into fibers using a winder. This process is ... [more ▼]

The manufacturing process of glass fibers used for the reinforcement of composite materials consistsin drawing a free jet of a molten glass at high temperature into fibers using a winder. This process is sensitive to numerous disturbances that can cause the fiber to break during the drawing process, and thus reduce the process efficiency. The underlying physics of the forming of a single fiber is investigated here through numerical simulations, and results are validated with measurements obtained on a dedicated experimental unit. Both a two-dimensional axisymmetric and a simplified one-dimensional model are used to simulate the high-temperature region before glass transition. The influence of key parameters and physical mechanisms on the internal stress is investigated through a sensitivity analysis. The simplified model is then used to identify the optimal operating window and to assess the impact of temperature inhomogeneities at the bushing plate. Results show that the initial region close to the tip is critical, and that a low cooling rate reduces the stress. Operating at high tip temperature, large drawing velocity and small tip radius is then found to be the best strategy to minimize the stress. Finally, it is shown that the heat pattern of the bushing plate is one of the most important causes for disturbance in the process. [less ▲]

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See detailGeneralized Pascal triangle for binomial coefficients of words
Leroy, Julien ULg; Rigo, Michel ULg; Stipulanti, Manon ULg

in Advances in Applied Mathematics (2016), 80

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word ... [more ▼]

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word. Similarly to the Sierpiński gasket that can be built as the limit set, for the Hausdorff distance, of a convergent sequence of normalized compact blocks extracted from Pascal triangle modulo 2, we describe and study the first properties of the subset of [0, 1] × [0, 1] associated with this extended Pascal triangle modulo a prime p. [less ▲]

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See detailThe Perceived Value of Passive Animal Health Surveillance: The Case of Highly Pathogenic Avian Influenza in Vietnam
Delabouglise, Alexis; Antoine-Moussiaux, Nicolas ULg; Phan, T.D et al

in Zoonoses and Public Health (2016), 63(2), 112-28

Economic evaluations are critical for the assessment of the efficiency and sustain- ability of animal health surveillance systems and the improvement of their effi- ciency. Methods identifying and ... [more ▼]

Economic evaluations are critical for the assessment of the efficiency and sustain- ability of animal health surveillance systems and the improvement of their effi- ciency. Methods identifying and quantifying costs and benefits incurred by public and private actors of passive surveillance systems (i.e. actors of veterinary author- ities and private actors who may report clinical signs) are needed. This study pre- sents the evaluation of perceived costs and benefits of highly pathogenic avian influenza (HPAI) passive surveillance in Vietnam. Surveys based on participatory epidemiology methods were conducted in three provinces in Vietnam to collect data on costs and benefits resulting from the reporting of HPAI suspicions to vet- erinary authorities. A quantitative tool based on stated preference methods and participatory techniques was developed and applied to assess the non-monetary costs and benefits. The study showed that poultry farmers are facing several options regarding the management of HPAI suspicions, besides reporting the fol- lowing: treatment, sale or destruction of animals. The option of reporting was associated with uncertain outcome and transaction costs. Besides, actors antici- pated the release of health information to cause a drop of markets prices. This cost was relevant at all levels, including farmers, veterinary authorities and private actors of the upstream sector (feed, chicks and medicine supply). One benefit associated with passive surveillance was the intervention of public services to clean farms and the environment to limit the disease spread. Private actors of the poultry sector valued information on HPAI suspicions (perceived as a non-mon- etary benefit) which was mainly obtained from other private actors and media. [less ▲]

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See detailTuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
Kumar, Amit; Abbas, Wasim; Colin, Laurence et al

in Scientific reports (2016), 6

Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In ... [more ▼]

Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In primary T cells treated with exogenous Nef or acutely infected with Nef-expressing HIV-1 in vitro, Akt became phosphorylated on serine(473) and threonine(308). In vitro, Akt activation mediated by Nef in T-cells was blocked by HIV protease inhibitors (PI), but not by reverse transcriptase inhibitors (RTI). Ex vivo, we found that the Akt pathway is hyperactivated in peripheral blood lymphocytes (PBLs) from cART naive HIV-1-infected patients. PBLs isolated from PI-treated patients, but not from RTI-treated patients, exhibited decreased Akt activation, T-cell proliferation and IL-2 production. We found that PI but not RTI can block HIV-1 reactivation in latently infected J-Lat lymphoid cells stimulated with various stimuli. Using luciferase measurement, we further confirmed that Nef-mediated reactivation of HIV-1 from latency in 1G5 cells was blocked by PI parallel to decreased Akt activation. Our results indicate that PI-mediated blockade of Akt activation could impact the HIV-1 reservoir and support the need to further assess the therapeutic use of HIV-1 PI in order to curtail latently infected cells in HIV-1-infected patients. [less ▲]

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See detailInfluence of methanol/sorbitol co-feeding rate on pAOX1 induction in a Pichia pastoris Mut+ strain in bioreactor with limited oxygen transfer rate.
Carly, F.; Niu, H.; Delvigne, Frank ULg et al

in Journal of industrial microbiology & biotechnology (2016), 43(4), 517-23

High Pichia pastoris biomass density could be obtained using high co-feeding rate of methanol and sorbitol in a fed-batch or continuous culture, while further higher feeding rate finally leads to oxygen ... [more ▼]

High Pichia pastoris biomass density could be obtained using high co-feeding rate of methanol and sorbitol in a fed-batch or continuous culture, while further higher feeding rate finally leads to oxygen limitation in bioreactor. In the literature, there is lack of report about AOX1 promoter regulation with regard to dissolved oxygen level (DO). Therefore, in this work, chemostat cultures were performed to investigate the cell growth, metabolism and regulation of the AOX1 promoter (pAOX1) regarding co-feeding rate of optimized methanol/sorbitol mixture (methanol fraction 0.60 C-mol/C-mol) using a P. pastoris Mut+/pAOX1-lacZ strain. The oxygen transfer rates (OTR) in bioreactor were kept in the range of typical values of large bioreactor, i.e., 4-8 g/(L h) if DO equals 30 % saturation or 5-10 g/(L h) if DO nears zero. For DO >0, an increase of the carbon fed led to an increase of pAOX1 induction. By contrast, when dissolved oxygen was completely depleted, methanol accumulated, causing a 30 % decrease of pAOX1 induction. However, this decrease is more likely to be lined to methanol accumulation than to low level of dissolved oxygen (<4 % DO). Methanol/sorbitol co-feeding allowed cells to adapt to oxygen transient limitations that often occur at industrial scale with reduced effect on pAOX1 induction. The optimal feeding rate tested here was 6.6 mmol C (DCW h)(-1) at an OTR of 8.28 g O2(L h)(-1) with over fivefold pAOX1 induction (probably directly associated with target protein productivity) compared with previous work. [less ▲]

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See detailSolidarity economy and its anarchist grammar
Frère, Bruno ULg

in Sociology and anthropology (2016), 5(24),

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local ... [more ▼]

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local Exange Trading Systems, proximity services, organic community supported agriculture and fairtrade distributions. Because they try to answer to the Aristotelian theoretical question “what can we do to live harmoniously together?”, these solidarity initiatives are deeply political in the philosophical sense of the term. They galvanize civic commitment at the “micro” level. But today, an important question arises regarding the kind of formal political institution that would speak in the name of all these initiatives. In France, some intellectuals who have an interest in these solidarity initiatives see them as new economic models with the potential to solve the current financial crisis, and they are eager for academic specialists and leaders of the movement to achieve some kind of consensus about the kind of concrete political identity such initiatives may be expected to generate. However this paper studies their way of establishing a basis for moving from micro level initiatives to substantial “macro” polity unity. Using the insights of french pragmatic sociology, and particularly the notion of grammar of justification, it aims to understand what the obstacles to this aim being realised are. [less ▲]

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See detailAbout the Uniform Hölder Continuity of Generalized Riemann Function
Bastin, Françoise ULg; Nicolay, Samuel ULg; Simons, Laurent ULg

in Mediterranean Journal of Mathematics (2016), 13(1), 101-117

In this paper, we study the uniform H\"{o}lder continuity of the generalized Riemann function~$R_{\alpha,\beta}$ (with $\alpha>1$ and $\beta>0$) defined by \[ R_{\alpha,\beta}(x)=\sum_{n=1}^{+\infty}\frac ... [more ▼]

In this paper, we study the uniform H\"{o}lder continuity of the generalized Riemann function~$R_{\alpha,\beta}$ (with $\alpha>1$ and $\beta>0$) defined by \[ R_{\alpha,\beta}(x)=\sum_{n=1}^{+\infty}\frac{\sin(\pi n^\beta x)}{n^\alpha},\quad x\in\mathbb{R}, \] using its continuous wavelet transform. In particular, we show that the exponent we find is optimal. We also analyse the behaviour of~$R_{\alpha,\beta}$ as $\beta$ tends to infinity. [less ▲]

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See detailChemical composition of essential oils and floral waters of Mentha longifolia (L.) Huds. from Senegal
Diop, Serigne Mbacké; Guèye, Momar Talla; Ndiaye, Ibrahima et al

in American Journal of Essential Oils and Natural Products (2016), 4(1), 46-49

Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively ... [more ▼]

Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively. Analysis of the essential oils, floral waters and the assay of pulegone were carried out by GC/FID and GC/MS. The major compounds identified in the oils were pulegone (52.0 and 42.4%), menthone (14.3 and 21.2%), 1, 8-cineole (13.1 and 11.4%) and isomenthone (9.0 and 13.2%) in the fresh and dried plants, respectively. Analyses revealed that floral waters were also characterized by the same major compounds as essential oils but at different rates. In these floral waters, pulegone constituted 60.2 and 47.0%, 1,8- cineole 7.9 and 19.6%, isomenthone 7.2 and 10.7%, menthone 6.4 and 9.2%, chrysanthenone 6.4 and 3.2% and α-terpineol 3.0 and 2.7% in the fresh and dried plants, respectively. The assay results of pulegone, a hepatotoxic compound, have shown very high levels (444.6 and 393.3mg/g) in both fresh and dried plants. [less ▲]

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See detailUne présentation rare de craniosténose associée à un crâne lacunaire
Vaessen, françois; Thimmesch, Mathieu; BORN, Jacques et al

in Revue Médicale de Liège (2016), 71(3), 120-123

A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its ... [more ▼]

A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its physiopathology remains up to now poorly understood; it is mostly associated with neural tube defects. The association of a lacunar skull with a craniosynostosis has rarely been described in the literature. The case of a 9-month-old patient presenting a multisutural craniosynostosis with a lacunar skull is reported in this article. The surgical treatment allowed to remodel the skull and to hope for a spontaneous regression of the lacunae. [less ▲]

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See detailWhat drives the development of community energy in Europe? The case of wind power cooperatives
Bauwens, Thomas ULg; Gotchev, Boris; Holstenkamp, Lars

in Energy Research & Social Science (2016), 13

The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being ... [more ▼]

The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being paid to the transition process towards a more decentralized configuration. This article examines the factors likely to foster citizen and community participation as regards wind power cooperatives in Denmark, Germany, Belgium and the UK. Using Elinor Ostrom’s Social-Ecological System Framework, the analysis highlights a double-edged phenomenon: prevailing and growing hostility towards cooperatives, on the one hand, and, on the other, strategic reactions to this evolution. What comes out indeed is that, throughout most of these countries, the emergence of some coordinated inter-organizational actions among cooperatives enables them to survive in their critical environment. [less ▲]

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See detailBi-objective Road and Pipe Network Design for Crude Oil Transport in the Sfax Region in Tunisia
Belaid, Emna ULg; Limbourg, Sabine ULg; Mostert, Martine ULg et al

in Procedia Engineering (2016), 142

In this paper, we examine a bi-objective road and pipe network design for crude oil transport in the Sfax region in Tunisia. In particular, we search for the minimum spanning trees (MST) that connect the ... [more ▼]

In this paper, we examine a bi-objective road and pipe network design for crude oil transport in the Sfax region in Tunisia. In particular, we search for the minimum spanning trees (MST) that connect the different oil fields with the port of La Skhirra. In the determination of the minimum spanning trees, two objectives are taken into account, i.e. accident risk and construction costs. By using an improved ɛ-constraint resolution technique, the Pareto optimal combinations of risk and cost are found. Results indicate that the network solutions by pipe outperform the solutions by road. When the minimum spanning trees for the two extremes on the Pareto curves, i.e. the cost minimum and risk minimum, are compared, one could note considerable differences in the links that form the MST. This implies that policy makers have an important role in deliberating between costs and risks. [less ▲]

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See detailApport du cathétérisme cardiaque dans le diagnostic et le traitement de la maladie coronarienne avant 40 ans
MEURICE, Caroline; LEGRAND, Victor ULg; PIERARD, Luc ULg

in Revue Médicale de Liège (2016), 71(3), 129-136

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See detailNew Hosts of The Lassa Virus.
Olayemi, Ayodeji; Cadar, Daniel; Magassouba, N. Faly et al

in Scientific Reports (2016), 6

Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to ... [more ▼]

Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa. [less ▲]

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See detailPlan de formation-insertion et garantie d'emploi : l'employeur qui s'engage
Cordier, Quentin ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), 14

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See detailThere is nothing more pratical than a good theory. Conceptuals tools for the Practioners in Conservation
Verbeeck, Muriel ULg

in Studies in Conservation (2016)

This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed ... [more ▼]

This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed from Gerard Genette are used to analyze a practical case: Dirty Corner, installation by Anish Kapoor vandalized in the gardens of Versailles. [less ▲]

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See detailConsumer acceptance of insect-based alternative meat products in Western countries
Caparros Megido, Rudy ULg; Gierts, Chloé; Blecker, Christophe ULg et al

in Food Quality & Preference (2016)

During the past few years, entomophagy has been increasing in significance. As insects are generally high in protein, they are principally considered as meat substitutes. Nevertheless, in Western ... [more ▼]

During the past few years, entomophagy has been increasing in significance. As insects are generally high in protein, they are principally considered as meat substitutes. Nevertheless, in Western countries, meat substitute consumption is actually very low, principally due to food neophobia and poor sensory qualities in comparison with meat. In insect particular case, food neophobia is clearly high. To reduce insect food neophobia, previous studies suggest to insert invisible insect in food preparation and/or to associate them with known flavors. In this study, a survey on entomophagy perception and hedonic tests were realized to assess the level of sensory-liking of hybrid insect-based burgers (beef, lentils, mealworms and beef, mealworms and lentils). Participants’ overall liking of the four burgers differed between genders and was influenced by burger appearance and taste. Women clearly preferred beef burger appearance, whereas men preferred the appearance of beef and insect-based burgers. Concerning insect-based burger taste, participants (men and women) rated it intermediately, between that of the beef and lentil burger, with a preference for the mealworm and beef burger. Results also showed that people with previous entomophagy experience was limited but that they gave globally higher ratings to all preparations. In conclusion, insect tasting sessions are important to decrease food neophobia, as they encourage people to “take the first step” and become acquainted with entomophagy. Nevertheless, insect integration into Western food culture will involve a transitional phase with minced or powdered insects incorporated into ready-to-eat preparations, as people are not ready to add insects to their diets in “whole form.” [less ▲]

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See detailBacterial and eukaryotic biodiversity patterns in terrestrial and aquatic habitats in the 1 Sør Rondane Mountains, Dronning Maud Land, East Antarctica
Obbels, Dagmar; Verleyen, Elie; Mano, Marie-José et al

in FEMS Microbiology Ecology (2016), 92

The bacterial and microeukaryotic biodiversity were studied using pyrosequencing analysis on a 454 GS FLX+ platform of partial SSU rRNA genes in terrestrial and aquatic habitats of the Sør Rondane ... [more ▼]

The bacterial and microeukaryotic biodiversity were studied using pyrosequencing analysis on a 454 GS FLX+ platform of partial SSU rRNA genes in terrestrial and aquatic habitats of the Sør Rondane Mountains, including soils, on mosses, endolithic communities, cryoconite holes and supraglacial and subglacial meltwater lenses. This inventory was complemented with Denaturing Gradient Gel Electrophoresis targeting Chlorophyta and Cyanobacteria. OTUs belonging to the Rotifera, Chlorophyta, Tardigrada, Ciliophora, Cercozoa, Fungi, Bryophyta, Bacillariophyta, Collembola and Nematodawere present with a relative abundance of at least 0.1% in the eukaryotic communities. Cyanobacteria, Proteobacteria, Bacteroidetes, Acidobacteria, FBP and Actinobacteria were the most abundant bacterial phyla. Multivariate analyses of the pyrosequencing data revealed a general lack of differentiation of both eukaryotes and prokaryotes according to habitat type. However, the bacterial community structure in the aquatic habitats was dominated by the filamentous cyanobacteria Leptolyngbya and appeared to be significantly different compared with those in dry soils, on mosses, and in endolithic habitats. A striking feature in all datasets was the detection of a relatively large amount of sequences new to science, which underscores the need for additional biodiversity assessments in Antarctic inland locations. [less ▲]

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See detailClostridium difficile in foods and animals: A comprehensive review
Rodriguez Diaz, Cristina ULg; Taminiau, Bernard ULg; Van Broeck, Johan et al

in Advances in Experimental Medicine and Biology (2016), 27

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See detailDevelopment of a Reference Database for Particle-Induced Gamma-ray Emission spectroscopy
Dimitriou, P.; Becker, H.-W.; Bogdanović-Radović, I. et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2016), 371

Particle-Induced Gamma-ray Emission (PIGE) is a powerful analytical technique that exploits the interactions of rapid charged particles with nuclei located near a sample surface to determine the ... [more ▼]

Particle-Induced Gamma-ray Emission (PIGE) is a powerful analytical technique that exploits the interactions of rapid charged particles with nuclei located near a sample surface to determine the composition and structure of the surface regions of solids by measurement of characteristic prompt γ rays. The potential for depth profiling of this technique has long been recognized, however, the implementation has been limited owing to insufficient knowledge of the physical data and lack of suitable user-friendly computer codes for the applications. Although a considerable body of published data exists in the nuclear physics literature for nuclear reaction cross sections with γ rays in the exit channel, there is no up-to-date, comprehensive compilation specifically dedicated to IBA applications. A number of PIGE cross-section data had already been uploaded to the Ion Beam Analysis Nuclear Data Library (IBANDL) (http://www-nds.iaea.org/ibandl) by members of the IBA community by 2011, however a preliminary survey of this body of unevaluated experimental data has revealed numerous discrepancies beyond the uncertainty limits reported by the authors. Using the resources and coordination provided by the IAEA, a concerted effort to improve the situation was made within the Coordinated Research Project on the Development of a Reference Database for PIGE spectroscopy, from 2011 to 2015. The aim of the CRP was to create a data library for Ion Beam Analysis that contains reliable and usable data on charged particle γ-ray emission cross sections that would be made freely available to the user community. As the CRP has reached its completion, we shall present its main achievements, including the results of nuclear cross-section evaluations and the development of a computer code that will become available to the public allowing for the implementation of a standardless PIGE technique. © 2015 Elsevier B.V. All rights reserved. [less ▲]

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See detailInfluences of the aqueous synthesis way and organosilane nature on the physico-chemical properties of porous alumina
Claude, Vincent ULg; Vilaseca, Miriam; Tatton, Andrew ULg et al

in European Journal of Inorganic Chemistry (2016), 2016(11), 1678-1689

The aqueous sol-gel synthesis of γ-Al2O3 modified with different silicon precursors {trimethoxysilane, triethoxysilane and N-[3-(trimethoxysilyl)propyl]ethylene diamine} has been investigated. Two ... [more ▼]

The aqueous sol-gel synthesis of γ-Al2O3 modified with different silicon precursors {trimethoxysilane, triethoxysilane and N-[3-(trimethoxysilyl)propyl]ethylene diamine} has been investigated. Two parameters have been studied: the silicon addition step and the type of silicon alkoxide. A first observation was that adding a silicon alkoxide either before or just after the precipitation step influences both the crystallinity and structure, whereas adding the alkoxide after a long agitation time only slightly modifies the support properties. It was also highlighted that due to their higher reactivity, silicon precursors with methoxy groups interact more strongly with the bulk alumina than the silicon precursors with ethoxy groups. This difference of Si location in the alumina structure permitted not only their resistance toward phase transition to be increased at high temperature, but also to stabilize them more efficiently against sintering under normal and steam conditions. Among the different silicon alkoxides tested, samples prepared with N-[3-(trimethoxysilyl)propyl]ethylene diamine showed very unusual properties. The alumina supports modified with this precursor showed grain-shaped nanocrystallites, whereas all other samples were platelet-like. As a result, this sample presented a very narrow pore diameter distribution of around 5 nm and a remarkably high specific surface area (530 m2/g). [less ▲]

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See detailSupplementation of transport and freezing media with anti-apoptotic drugs improves ovarian cortex survival
HENRY, Laurie ULg; Fransolet, Maïté ULg; LABIED, Soraya ULg et al

in Journal of Ovarian Research (2016)

Background: Ovarian tissue preservation is proposed to patients at risk of premature ovarian failure, but this procedure still needs to be optimized. To limit injury during ovarian tissue cryopreservation ... [more ▼]

Background: Ovarian tissue preservation is proposed to patients at risk of premature ovarian failure, but this procedure still needs to be optimized. To limit injury during ovarian tissue cryopreservation, anti-apoptotic drugs were added to the transport and freezing media of ovarian cortex tissue. Methods: Sheep ovaries were transported, prepared and frozen in solutions containing vehicle or anti-apoptotic drugs (Z-VAD-FMK, a pan-caspase inhibitor, or sphingosine-1-phosphate (S1P), a bioactive lipid). After the tissue was thawed, the ovarian cortex was cultured for 2 or 6 days. Follicular quantification and morphological and proliferation analyses were performed on histological sections. Results: After 2 days of culture, S1P improved the quality of primordial follicles; higher densities of morphologically normal and proliferative primordial follicles were found. Z-VAD-FMK displayed similar effects by preserving global primordial follicular density, but this effect was evident after 6 days of culture. This drug also improved cell proliferation after 2 and 6 days of culture. Conclusions: Our results showed that the addition of S1P or Z-VAD-FMK to the transport and freezing media prior to ovarian tissue cryopreservation improves primordial follicular quality and therefore improves global tissue survival. This should ultimately lead to improved fertility restoration after auto-transplantation. [less ▲]

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See detailStructural Proteomics of Herpesviruses.
Leroy, Baptiste; Gillet, Laurent ULg; Vanderplasschen, Alain ULg et al

in Viruses (2016), 8(2),

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have ... [more ▼]

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have been unsuccessful because these viruses have developed numerous immune evasion mechanisms. Therefore, a better understanding of their complex lifecycle is needed. In particular, while the genome of numerous herpesviruses has been sequenced, the exact composition of virions remains unknown for most of them. Mass spectrometry has recently emerged as a central method and has permitted fundamental discoveries in virology. Here, we review mass spectrometry-based approaches that have recently allowed a better understanding of the composition of the herpesvirus virion. In particular, we describe strategies commonly used for proper sample preparation and fractionation to allow protein localization inside the particle but also to avoid contamination by nonstructural proteins. A collection of other important data regarding post-translational modifications or the relative abundance of structural proteins is also described. This review also discusses the poorly studied importance of host proteins in herpesvirus structural proteins and the necessity to develop a quantitative workflow to better understand the dynamics of the structural proteome. In the future, we hope that this collaborative effort will assist in the development of new strategies to fight these infections. [less ▲]

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See detailContext-dependent roles for lymphotoxin-beta receptor signaling in cancer development.
Fernandes, Monica T.; Dejardin, Emmanuel ULg; Santos, Nuno R. Dos

in Biochimica et biophysica acta (2016)

The LTalpha1beta2 and LIGHT TNF superfamily cytokines exert pleiotropic physiological functions through the activation of their cognate lymphotoxin-beta receptor (LTbetaR). Interestingly, since the ... [more ▼]

The LTalpha1beta2 and LIGHT TNF superfamily cytokines exert pleiotropic physiological functions through the activation of their cognate lymphotoxin-beta receptor (LTbetaR). Interestingly, since the discovery of these proteins, accumulating evidence has pinpointed a role for LTbetaR signaling in carcinogenesis. Early studies have shown a potential anti-tumoral role in a subset of solid cancers either by triggering apoptosis in malignant cells or by eliciting an anti-tumor immune response. However, more recent studies provided robust evidence that LTbetaR signaling is also involved in diverse cell-intrinsic and microenvironment-dependent pro-oncogenic mechanisms, affecting several solid and hematological malignancies. Consequently, the usefulness of LTbetaR signaling axis blockade has been investigated as a potential therapeutic approach for cancer. Considering the seemingly opposite roles of LTbetaR signaling in diverse cancer types and their key implications for therapy, we here extensively review the different mechanisms by which LTbetaR activation affects carcinogenesis, focusing on the diverse contexts and different models assessed. [less ▲]

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