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See detailLessons learned from the virus indexing of Musa germplasm: insights from a multiyear collaboration
De Clerck, Caroline ULiege; Crew, Kathy; Van den Houwe, Ines et al

in Annals of Applied Biology (2017)

The Bioversity International Transit Center (ITC) for banana hosts more than 1500 accessions largely covering the genetic diversity of the genus Musa. Its objective is to conserve this genetic diversity ... [more ▼]

The Bioversity International Transit Center (ITC) for banana hosts more than 1500 accessions largely covering the genetic diversity of the genus Musa. Its objective is to conserve this genetic diversity and to supply plant materials to users worldwide. All the Musa accessions must be tested for virus presence and, if infected, virus elimination must be attempted, to enable the supply of virus-free plant material. An international collaborative effort launched under the auspices of Bioversity International (2007–2013) finally led to the implementation of a two-step process to test the accessions. The first step, called pre-indexing, involved only molecular tests and was designed as a pre-screen of new germplasm lines or existing accessions to reduce the need for post-entry virus therapy and repeated virus indexing. The second step, called full indexing, was performed on either older existing accessions or newer accessions which tested negative during pre-indexing, and involvedmolecular tests, transmission electron microscopy (TEM) and symptom observation. In total, 270 germplasm lines (434 samples) were pre-indexed; while full indexing was carried out on 243 accessions (68 of which had been pre-indexed). A significant proportion of the samples tested during pre-indexing was infected with at least one virus (68%), showing the utility of this early pre-screening step. Banana streak OL virus and Banana mild mosaic virus were the most commonly detected viruses during both pre- and full indexing. For 22 accessions, viral particles were observed by TEM in full indexing while the molecular tests were negative, underlining the importance of combining various detection techniques. After full indexing, viruses were not detected in 166 accessions, which were then released for international distribution from the ITC. This publication exemplifies how the practical application of diagnostic protocols can raise fundamental questions related to their appropriate use in routine practice and the need for their continuous monitoring and improvement after their first publication. [less ▲]

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See detailMorphology of the filtration apparatus of three planktivorous fishes and relation with ingested anthropogenic particles
Collard, France ULiege; Gilbert, Bernard ULiege; Eppe, Gauthier ULiege et al

in Marine Pollution Bulletin (2017)

Anthropogenic particles (APs), including microplastics, are ingested by a wide variety of marine organisms. Exposure of Clupeiformes (e.g. herrings, anchovies, sardines) is poorly studied despite their ... [more ▼]

Anthropogenic particles (APs), including microplastics, are ingested by a wide variety of marine organisms. Exposure of Clupeiformes (e.g. herrings, anchovies, sardines) is poorly studied despite their economic and ecological importance. This study aims to describe the morphology of the filtration apparatus of three wild-caught Clupeiformes (Sardina pilchardus, Clupea harengus and Engraulis encrasicolus) and to relate the results to ingested APs. Consequently, the species with the more efficient filtration apparatus will be more likely to ingest APs. We hypothesized that sardines were the most exposed species. The filtration area and particle retention threshold were determined in the three species, with sardines displaying the highest filtration area and the closest gill rakers. Sardines ingested more fibers and smaller fragments, confirming that it is the most efficient filtering species. These two results lead to the conclusion that, among the three studied, the sardine is the species most exposed to APs. [less ▲]

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See detailUse of Intra-Articular Hyaluronic Acid in the Management of Knee Osteoarthritis in Clinical Practice
Cooper, Cyrus; Rannou, François; Richette, Pascal et al

in Arthritis Care and Research (2017), EPub ahead of print

This review emphasizes the safety profile of intra-articular hyaluronic acid treatment of knee osteoarthritis, as well as its moderate but real efficacy on symptoms, which is in the same range than other ... [more ▼]

This review emphasizes the safety profile of intra-articular hyaluronic acid treatment of knee osteoarthritis, as well as its moderate but real efficacy on symptoms, which is in the same range than other pharmacological modalities used in this indication. Effectiveness of intraarticular hyaluronic acid has also been highlighted based on ‘real-life’ data, together with the clinical benefit of systematic repeated treatment cycles, and the influence of the molecular weight of hyaluronic acid on treatment outcome. These aspects should be particularly helpful to clinicians when making personalized care decisions. [less ▲]

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See detailTracing Migrant-Mothers’ ‘Return’ Narratives in the Mexico-U.S and Peru-Belgium Migratory Circuits.
Vivas Romero, Maria ULiege; Sanchez-Martinez, Anabela

in Travaux et recherches dans les amériques du centre (2017)

How do contemporary migrant mothers strategize return to their home countries? And how does the social protections available for their bi-national children in sending and destination countries factor in ... [more ▼]

How do contemporary migrant mothers strategize return to their home countries? And how does the social protections available for their bi-national children in sending and destination countries factor in the decision to return? Through this contribution, we aimed to tackle these questions. We draw from the analysis of two longitudinal migratory careers and argue that our participant’s return decisions were influenced both by their children’s effective access to social protection and their subjective perceptions of ‘good-motherhood’. This Trans-Atlantic comparison shows how different situated-institutional-contexts, cultures of care and motherhood resulted into different patterns of mobility for these women and their families. [less ▲]

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See detailLa «Health Literacy»,un moyen pour réduire les inégalités sociales de santé
Bragard, Isabelle ULiege; COUCKE, Philippe ULiege; Pétré, Benoît ULiege et al

in Revue Médicale de Liège (2017), 72(1),

Health literacy (HL) is defined as ‘the knowledge, motivation, and competences to access, understand, appraise and apply health information in order to make judgments and take decisions in everyday life ... [more ▼]

Health literacy (HL) is defined as ‘the knowledge, motivation, and competences to access, understand, appraise and apply health information in order to make judgments and take decisions in everyday life concerning health care, disease prevention and health promotion to maintain or improve quality of life’. This concept begins to be recognized as a priority area for action at political level in Belgium. Indeed, a limited HL may affect health by leading, by example, with poorer management of chronic diseases, more hospital admissions and premature deaths. This paper addresses the question of HL evaluation, improvement interventions as well as the many challenges that remain in this area. HL seems fundamental to the development of better health management. It would allow patients to play a more active role in health care, to involve all health stakeholders, and to contribute to a more sustainable health system. Improving HL could allow better equal access to health care. [less ▲]

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See detailL'attention chez Descartes. Aspect mental et aspect physiologique
Hatfield, Gary; Dubouclez, Olivier ULiege

in Les études philosophiques (2017), (1), 7-25

Résumé. – Bien qu’il n’ait pas donné une analyse approfondie du concept d’attention, Descartes invoque fréquemment l’attention. Il a observé et décrit une diversité de phénomènes attentionnels et ... [more ▼]

Résumé. – Bien qu’il n’ait pas donné une analyse approfondie du concept d’attention, Descartes invoque fréquemment l’attention. Il a observé et décrit une diversité de phénomènes attentionnels et les a replacés dans un cadre explicatif qui prend en compte aussi bien leurs aspects mentaux que physiologiques. Il a mis en relation la focalisation de l’attention et les actes de la volonté. Dans le cas de l’attention aux perceptions sensibles ou aux actes de l’imagination, il a décrit en détails les processus physiologiques qui captent l’attention, la maintiennent ou la détournent. Ces processus physiologiques montrent bien que la personne cartésienne constitue une unité fonctionnelle formée d’une âme et d’un corps. [less ▲]

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See detailAdded value and limitations of electrical source localization
RIKIR, Estelle ULiege

in Epilepsia (2017), 58(1), 174-175

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See detailEstrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura.
Chauvel, Virginie; Multon, Sylvie ULiege; Schoenen, Jean ULiege

in Cephalalgia : An International Journal of Headache (2017)

Background: Cortical spreading depression (CSD) is the likely culprit of the migraine aura. Migraine is sexually dimorphic and thought to be a ‘‘low 5-HT’’ condition. We sought to decipher the ... [more ▼]

Background: Cortical spreading depression (CSD) is the likely culprit of the migraine aura. Migraine is sexually dimorphic and thought to be a ‘‘low 5-HT’’ condition. We sought to decipher the interrelation between serotonin, ovarian hormones and cortical excitability in a model of migraine aura. Methods: Occipital KCl-induced CSDs were recorded for one hour at parieto-occipital and frontal levels in adult male (n 1⁄4 16) and female rats (n 1⁄4 64) one hour after intraperitoneal (i.p.) injection of 5-hydroxytryptophan (5-HTP) or NaCl. Sixty-five oophorectomized females were treated with estradiol- (E2) or cholesterol- (Chol) filled capsules. Two weeks later we recorded CSDs after 5-HTP/NaCl injections before or 20 hours after capsule removal. Results: 5-HTP had no effect in males, but decreased CSD frequency in cycling females, significantly so during estrus, at parieto-occipital (􏰀3.5CSD/h, p<0.001) and frontal levels (􏰀2.5CSD/h, p1⁄40.014). In oophorectomized rats, CSD susceptibility increased during E2 treatment at both recording sites (þ5CSD/h, p1⁄40.001 and þ3CSD/h, p<0.01), but decreased promptly after E2 withdrawal (􏰀4.7CSD/h, p < 0.001 and 􏰀1.7CSD/h, p 1⁄4 0.094). The CSD inhibitory effect of 5-HTP was significant only in E2-treated rats (􏰀3.4CSD/h, p 1⁄4 0.006 and 􏰀1.8CSD/h, p 1⁄4 0.029). Neither the estrous cycle phase, nor E2 or 5-HTP treatments significantly modified CSD propagation velocity. Conclusion: 5-HTP decreases CSD occurrence in the presence of ovarian hormones, suggesting its potential efficacy in migraine with aura prophylaxis in females. Elevated E2 levels increase CSD susceptibility, while estrogen withdrawal decreases CSD. In a translational perspective, these findings may explain why migraine auras can appear during pregnancy and why menstrual-related migraine attacks are rarely associated with an aura. [less ▲]

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See detailLe nintedanib (OFEV) : nouveau traitement remboursé dans la fibrose pulmonaire idiopathique
GUIOT, Julien ULiege; CORHAY, Jean-Louis ULiege; Louis, Renaud ULiege

in Revue médico-chirugicale du CHU de Charleroi (2017), 2017-1

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See detailMICROPALEONTOLOGY OF THE LOWER MESOPROTEROZOIC ROPER GROUP, AUSTRALIA, AND IMPLICATIONS FOR EARLY EUKARYOTIC EVOLUTION
Javaux, Emmanuelle ULiege; Knoll, Andrew H.

in Journal of Paleontology (2017)

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See detailOpinion Statement ECJ-TF 2/2016 on the Decision of the Court of Justice of the European Union of 13 July 2016 in Brisal and KBC Finance Ireland (Case C-18/15), on the Admissibility of Gross Withholding Tax of Interest
CFE ECJ task Force; Richelle, Isabelle ULiege

in European Taxation (2017), 2017

This Opinion Statement of the CFE ECJ Task Force analyses the ECJ’ s decision in Brisal and KBC Finance Ireland (Case C-18/15) of 13 July 2016. Following a Portuguese reference for a preliminary ruling ... [more ▼]

This Opinion Statement of the CFE ECJ Task Force analyses the ECJ’ s decision in Brisal and KBC Finance Ireland (Case C-18/15) of 13 July 2016. Following a Portuguese reference for a preliminary ruling, the Court’ s decision provides further clarification on the permissibility of withholding taxation within the European Union. In relation to interest, the Court held that non-resident taxpayers may be subject to withholding taxes (even if comparable residents pursuing the same activity are not) but that non-residents may nevertheless not be taxed on gross income (when comparable residents are taxed on net profits) and are, therefore, entitled to deduct expenses directly connected to their business activity [less ▲]

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See detailPESTO SAUCE TYPE PRODUCTS: INFLUENCE OF BEESWAX AND STORAGE CONDITIONS ON RHEOLOGY AND COLLOIDAL STABILITY
Bouacida, Saoussen; Muresan, Vlad; Essaidi, Ismahen et al

in Journal of Microbiology, Biotechnology and Food Sciences (2017), 6(3), 911-920

One of the major problems for pesto sauce type products is the tendency of oil to cream, causing their alteration and decreasing consumer’s acceptability. In this study, colloidal and oxidative stability ... [more ▼]

One of the major problems for pesto sauce type products is the tendency of oil to cream, causing their alteration and decreasing consumer’s acceptability. In this study, colloidal and oxidative stability of pesto samples with (0.5-1.2%) of beeswax was evaluated during storage at 4, 20 and 40°C. The rheological behavior and color analysis was evaluated at the same temperatures. Sensory evaluation by using a hedonic test was also perfomed. Increasing the samples beeswax content increased the pesto colloidal stability. The samples with 0.8-1.2% have the highest stability and overall performed well on sensory analysis. The peroxide values of samples increased significantly (p<0.05) with storage time and temperature, as well as the p-anisidine values. During the storage at 40°C, peroxide values of samples without wax and with 1,2% wax increased from 11.75 to 33.81 and 32.72 meq O2/kg, respectively. In the same condition, p-Anisidine values increased from 4.51 to 10.71 and 9.94, respectively. For these same samples stored 793 h, peroxide values increased from 13.33 to 33.81 and to 32.72 meq O2/kg, when the temperature increased from 4 to 40°C. The same observation was made for p-anisidine values, which increased from 8.40 to 10.71 and 9.94. As expected, the pesto samples showed the best oxidative stability at low temperature. It was shown that beeswax content, temperature and time of storage are important parameters for controlling pesto rheology, colloidal and oxidative stability. In fact, the pseudo plasticity of samples increases with increasing beeswax added and with decreasing the temperature. The colloidal and oxidative stability of samples decreased as the storage time and temperature increased. [less ▲]

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See detailVous êtes formidables
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2017), 60

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See detailL’accès des filles à l’enseignement supérieur au Burkina Faso : choix parentaux, parcours d’étudiantes et défis
Wouango, Joséphine ULiege

in International Review of Education (2017), 63(2),

Qu'est-ce qui motive les parents des milieux moins aisés à investir dans une scolarisation prolongée de leurs filles ? Qu'est-ce qui amène les filles issues de ces milieux à se maintenir dans le système ... [more ▼]

Qu'est-ce qui motive les parents des milieux moins aisés à investir dans une scolarisation prolongée de leurs filles ? Qu'est-ce qui amène les filles issues de ces milieux à se maintenir dans le système scolaire jusqu'à l'université ? De nombreuses recherches sur le système éducatif burkinabé montrent qu'il existe encore des disparités entre filles et garçons à tous les niveaux, avec une aggravation de l'écart à mesure que le niveau d'études augmente. Dans ces conditions, la perspective pour des filles issues de familles moins aisées de poursuivre des études supérieures est moins certaine. Pourtant, on remarque une relative présence de filles issues de ces milieux à l'université de Ouagadougou. À partir d'une enquête qualitative auprès d'étudiantes et de leurs parents, cet article met en exergue les logiques sociales qui expliquent le parcours scolaire particulier de ces filles. Le niveau de scolarisation des aînés, la place de la fille dans la fratrie ou le souci d'équité sont des facteurs à l'origine du choix de certains parents de scolariser leurs filles. Les parents se réfèrent à plusieurs formes de justification en faveur des études universitaires des filles, parmi lesquelles la logique de fidélité des filles dans le retour de l’aide revient à de multiples reprises. Quant aux étudiantes, elles évoquent des motivations diverses pour expliquer leur parcours scolaire et universitaire, souvent émaillé de difficultés, notamment la volonté d’aider leurs parents. L’article montre en outre l’importance du soutien familial dans l’entrée des filles à l’école et à l’université, ainsi que dans la poursuite et la réussite de leurs études. [less ▲]

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See detailMethane balance of an intensively grazed pasture and estimation of the enteric methane emissions from cattle
Dumortier, Pierre ULiege; Aubinet, Marc ULiege; Beckers, Yves ULiege et al

in Agricultural and Forest Meteorology (2017), 232

The methane turbulent fluxes of an intensively grazed pasture were measured continuously from June 2012 to December 2013 at the Dorinne Terrestrial Observatory (DTO) in Belgium. During grazing periods ... [more ▼]

The methane turbulent fluxes of an intensively grazed pasture were measured continuously from June 2012 to December 2013 at the Dorinne Terrestrial Observatory (DTO) in Belgium. During grazing periods, the fluxes were dominated by enteric fermentation and were found to be strongly related to cow stocking density. In 2013, total emission from the pasture was found between 9 and 11 g CH4 m−2, 97% of which being emitted during grazing periods. Emission per LU (livestock unit) was estimated in a non-invasive way by integrating eddy covariance fluxes over large periods and by assuming a homogeneous average cattle disposition on the pasture. This estimate was compared to the one obtained during confinement periods, where cows were confined in a small part of the pasture. The emission per LU varied between 104 and 134 g CH4 LU−1 day−1 (13 and 17 g CH4 kg DMI−1), depending on the dataset and the computation method used. Diel course was characterized by two emission peaks, one in the morning and a larger one in the afternoon. For rest periods (no cattle on the pasture), small emissions were observed (median and mean values of 0.5 and 1.5 mg CH4 m−2 day−1, respectively). [less ▲]

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See detailLa gestion des ressources publiques : acteurs, enjeux et processus
Piron, Damien ULiege; Weerts, Audrey ULiege; Wintgens, Sophie ULiege

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2017), 28

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See detailUsutu virus, Belgium, 2016
Garigliany, Mutien-Marie ULiege; Linden, Annick ULiege; Gilliaux, Gautier ULiege et al

in Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (2017), 48(1), 116-119

During late summer 2016, in a northwest European region extending over Belgium, the Netherlands and the eastern border of the German state of North Rhine Westphalia, an outbreak of wild bird deaths ... [more ▼]

During late summer 2016, in a northwest European region extending over Belgium, the Netherlands and the eastern border of the German state of North Rhine Westphalia, an outbreak of wild bird deaths occurred similar to those reported on the continent since 1996. Dead birds were necropsied and examined by complementary methods. Pathologic and immunohistological investigations strongly suggested an infection by Usutu virus. Subsequently, genomic segments of the said virus were detected, the virus was isolated and its complete genome was sequenced. The strain, designated Usutu-LIEGE, is a close phylogenetic relative of those isolated in Germany which form a distinct group within the USUV phylogeny, the so-called Europe_3 lineage. Should this outbreak recapitulate the characteristics of those in southwest Germany in 2011 and in/around Vienna (Austria) in 2001, it is expected that specific avian populations in the affected area will face a significant reduction in size for a few years. [less ▲]

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See detailBioclimatism in Architecture : an evolutionary perspective
Nguyen, Anh Tuan; Reiter, Sigrid ULiege

in International Journal of Design and Nature and Ecodynamics (2017), 12(1), 16-29

Fundamentals of vernacular architecture have been used in bioclimatic architecture which has gradually become the inspiration of various movements in contemporary architecture. The study points out that ... [more ▼]

Fundamentals of vernacular architecture have been used in bioclimatic architecture which has gradually become the inspiration of various movements in contemporary architecture. The study points out that the development of bioclimatism in architecture has followed the pattern of a natural evolutionary process in which “natural selection” is likely motivated by several factors, including resources and environment problems, and driven by different mechanisms including novel building design concepts and methods, new standards and codes, discoveries in building science and construction costs. This study is an effort aimed to clarify the evolution process of the bioclimatic approach in architecture over time and its influences on contemporary movements in architecture. The paper shows also that the evolutionary theory generated new scientific tools able to improve building design thanks to simulation-based optimization methods applied to building performances. Finally, this study investigates new motivations in the era of climate change whose effects are expected to introduce more challenges as well as more trends towards a sustainable built environment through the new concept of Eco-adaptive architecture. [less ▲]

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See detailEuropean consensus-based (S2k) Guideline on the Management of Herpes Zoster - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 2: Treatment
WERNER R.N.; NIKKELS, Arjen ULiege; MARINOVIC B. et al

in Journal of the European Academy of Dermatology & Venereology (2017)

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim ... [more ▼]

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim of this European project was the elaboration of a consensus-based guideline on the management of patients who present with HZ, considering different patient populations and different localizations. This interdisciplinary guideline aims at an improvement of the outcomes of the acute HZ management concerning disease duration, acute pain and quality of life of the affected patients and at a reduction in the incidence of postherpetic neuralgia (PHN) and other complications. The guideline development followed a structured and pre-defined process, considering the quality criteria for guidelines development as suggested by the AGREE II instrument. The steering group was responsible for the planning and the organization of the guideline development process (Division of Evidence-Based Medicine, dEBM). The expert panel was nominated by virtue of clinical expertise and/or scientific experience and included experts from the fields of dermatology, virology/infectiology, ophthalmology, otolaryngology, neurology and anaesthesiology. Recommendations for clinical practice were formally consented during the consensus conference, explicitly considering different relevant aspects. The guideline was approved by the commissioning societies after an extensive internal and external review process. In this second part of the guideline, therapeutic interventions have been evaluated. The expert panel formally consented recommendations for the treatment of patients with HZ (antiviral medication, pain management, local therapy), considering various clinical situations. Users of the guideline must carefully check whether the recommendations are appropriate for the context of intended application. In the setting of an international guideline, it is generally important to consider different national approaches and legal circumstances with regard to the regulatory approval, availability and reimbursement of diagnostic and therapeutic interventions. [less ▲]

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See detailHabitat selection and reproduction of newts in networks of fish and fishless aquatic patches
Winandy, Laurane ULiege; Legrand, Pauline ULiege; Denoël, Mathieu ULiege

in Animal Behaviour (2017), 123

The spatial distribution of organisms in patchy environments can be determined by the relationship between habitat quality and animal behaviour. In species with complex life cycles, such as pond-breeding ... [more ▼]

The spatial distribution of organisms in patchy environments can be determined by the relationship between habitat quality and animal behaviour. In species with complex life cycles, such as pond-breeding amphibians, the selection of a suitable wetland is crucial. While the traditional view of amphibian ecology suggests strong site fidelity and low vagility, more recent research highlights mechanisms involving active site choice through avoidance behaviour and bet-hedging strategies in heterogeneous environments. The introduction of fish to the aquatic environment is one of the factors that may alter site selection and lead to local dispersal. In this context, we investigated the habitat choice of Alpine newts, Ichthyosaura alpestris, in networks of fish (Carassius auratus) and fishless aquatic patches. Using a laboratory design consisting of aquaria divided into two water tanks connected by a terrestrial platform, we assessed newt distribution and movement between patches. During the breeding period, we compared the reproductive success of individuals in two types of networks. We found that newts escaped fish by rapidly changing aquatic patches and then aggregating in safe aquatic patches that were free of fish. In the fish network, newts maintained reproduction, but the high local abundance resulted in decreased sexual activity and egg production and increased use of the terrestrial habitat. However, in the fishless network, newts moved between aquatic patches several times, exhibited more courtship behaviour and laid more eggs than they did in the fish networks. Our results showed both adaptive habitat switching due to environmental risks in the fish network and habitat supplementation (i.e. use of alternative resources) in the fishless network. Such studies on movement behaviour and habitat selection have conservation implications in showing that the persistence of native species in invaded networks depends on the rescue effect, with immigration to fish-free habitats potentially preventing local extinction. [less ▲]

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See detailNullité et restitutions – À propos de la nullité d’une convention portant mise à disposition de travailleurs conclue en méconnaissance de la loi du 24 juillet 1987
Daumen, Laura ULiege

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2017), 2017(1), 41

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See detailAssessment of vitamin D status - a changing landscape.
Herrmann, Markus; Farrell, Christopher-John L.; Pusceddu, Irene et al

in Clinical Chemistry & Laboratory Medicine (2017)

In recent years it has been shown that vitamin D deficiency is associated with an increased incidence as well as the progression of a broad range of diseases including osteoporosis, rickets ... [more ▼]

In recent years it has been shown that vitamin D deficiency is associated with an increased incidence as well as the progression of a broad range of diseases including osteoporosis, rickets, cardiovascular disease, autoimmune disease, multiple sclerosis and cancer. Consequently, requests for the assessment of vitamin D status have increased dramatically. Despite significant progress in the analysis of vitamin D metabolites and an expansion of our pathophysiological knowledge of vitamin D, the assessment of vitamin D status remains a challenging and partially unresolved issue. Current guidelines from scientific bodies recommend the measurement of 25-hydroxy vitamin D (25-OHD) in blood as the preferred test. However, growing evidence indicates significant limitations of this test, including analytical aspects and interpretation of results. In addition, the relationships between 25-OHD and various clinical indices, such as bone mineral density and fracture risk, are rather weak and not consistent across races. Recent studies have systematically investigated new markers of vitamin D status including the vitamin D metabolite ratio (VMR) (ratio between 25-OHD and 24,25-dihydroxy vitamin D), bioavailable 25-OHD [25-OHD not bound to vitamin D binding protein (DBP)], and free 25-OHD [circulating 25-OHD bound to neither DBP nor albumin (ALB)]. These parameters may potentially change how we will assess vitamin D status in the future. Although these new biomarkers have expanded our knowledge about vitamin D metabolism, a range of unresolved issues regarding their measurement and the interpretation of results prevent their use in daily practice. It can be expected that some of these issues will be overcome in the near future so that they may be considered for routine use (at least in specialized centers). In addition, genetic studies have revealed several polymorphisms in key proteins of vitamin D metabolism that affect the circulating concentrations of vitamin D metabolites. The affected proteins include DBP, 7-dehydrocholesterol synthase and the vitamin D receptor (VDR). Here we aim to review existing knowledge regarding the biochemistry, physiology and measurement of vitamin D. We will also provide an overview of current and emerging biomarkers for the assessment of vitamin D status, with particular attention methodological aspects and their usefulness in clinical practice. [less ▲]

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See detailRelevance of vitamin D in the pathogenesis and therapy of frailty.
Bruyère, Olivier ULiege; Cavalier, Etienne ULiege; Buckinx, Fanny ULiege et al

in Current Opinion in Clinical Nutrition & Metabolic Care (2017), 20(1), 26-29

PURPOSE OF REVIEW: This article reviews recently published evidence regarding the role of vitamin D in the physiopathology of physical frailty in elderly populations and its role in the management of this ... [more ▼]

PURPOSE OF REVIEW: This article reviews recently published evidence regarding the role of vitamin D in the physiopathology of physical frailty in elderly populations and its role in the management of this geriatric condition. RECENT FINDINGS: Some recent studies have found a low level of 25-hydroxyvitamin D, considered the best marker of vitamin D status, in frail individuals. All prospective studies consistently report that low vitamin D status is associated with an increased risk of becoming frail. Recent studies also suggest that the relationship between vitamin D status and frailty is largely mediated by the development of sarcopenia. Very few well designed randomized controlled trials are available that assess the effectiveness of vitamin D supplementation in the prevention or management of frailty. In the absence of specific guidelines, a minimal serum 25-hydroxyvitamin D level of 75 nmol/l is proposed for frail elderly patients by some scientific societies. The doses necessary to reach this target are between 800 and 2000 IU/day. SUMMARY: Several studies suggest a potential effect of vitamin D on physical frailty but large clinical trials are lacking at this time to provide solid evidence of clinical benefit. [less ▲]

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See detailWork–Home Interface and Well-Being: A Cross-Lagged Analysis
Babic, Audrey ULiege; Stinglhamber, Florence; Bertrand, Françoise ULiege et al

in Journal of Personnel Psychology (2017), 16

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See detailImpact of food type on respiration, fractionation and turnover of carbon and nitrogen stable isotopes in the marine amphipod Gammarus aequicauda (Martynov, 1931).
Remy, François ULiege; Darchambeau, François ULiege; Melchior, Aurélie et al

in Journal of Experimental Marine Biology & Ecology (2017), 486

This study experimentally determined the impact of food source type on turnover rate and trophic enrichment factors (TEFs or ∆) of δ13C and δ15N, as well as on respiration rate, in captive populations of ... [more ▼]

This study experimentally determined the impact of food source type on turnover rate and trophic enrichment factors (TEFs or ∆) of δ13C and δ15N, as well as on respiration rate, in captive populations of the marine amphipod Gammarus aequicauda. Gammarus aequicauda (318 individuals) were fed ad libitum with three food sources animal, algae, and dead Posidonia oceanica leaves (also called “litter”), varying in palatability, digestibility, nutritional qualities and isotopic compositions, for between four and six weeks in a controlled feeding experiment. The resulting death rate was lower for the amphipods fed with animal treatment (30.9%) than for individuals fed with algal (65.9%) or litter treatment (64.4%), indicating a better fitness of the individuals fed with the animal food source. Respiration rates also differed highly among the treatments. Animal treatment showed higher respiration rates than algal and litter treatments, potentially due to the toxicity of the algae and the very low nutritional quality of the litter. Amphipods fed with these treatments might have entered in a “low activity state” to cope with these unsuitable food sources, inducing low respiration rates. Due to the very low assimilation and toxicity of the algae source, turnover rate for δ13C was impossible to determine. Turnover rate for δ13C was much faster (half-life = 12.55 days) for amphipods fed with the animal food source than for amphipods fed with litter (half-life = 51.62 days), showing the faster assimilation of the most nutritionally optimal food sources by G. aequicauda. Turnover for δ15N was impossible to determine because the amphipods were already at isotopic equilibrium at the beginning of the experiment. Despite the detritus feeder status of Gammarus aequicauda, TEFs for the animal treatments were in accordance with values generally found for carnivorous organisms (∆13C = 0.9 ± 0.7‰; ∆15N = 2.9 ± 0.6‰). TEFs for the litter treatment were in accordance with values generally corresponding to detritivorous organisms (∆13C = 1.2‰; ∆15N = 1.0 ± 0.4‰). SIAR mixing model outputs obtained with these new TEF values were more constrained and coherent than outputs obtained with general literature TEFs. This study thus demonstrated the non-negligible impact of the food source on Gammarus aequicauda physiological status, fitness and turnover rates, but also on TEFs—highlighting the importance of TEF experimental calculations for every potential food source of a given organism to ensure more robust isotopic data interpretation. [less ▲]

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See detailEuropean consensus-based (S2k) Guideline on the Management of Herpes Zoster - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 1: Diagnosis
WERNER R. N.; NIKKELS, Arjen ULiege; MARINOVIC B. et al

in Journal of the European Academy of Dermatology & Venereology (2017), 31

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim ... [more ▼]

Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life of affected patients. Different therapeutic approaches to treat acute HZ are available. The aim of this European project was the elaboration of a consensus-based guideline on the management of patients who present with HZ, considering different patient populations and different localizations. This interdisciplinary guideline aims at an improvement of the outcomes of the acute HZ management concerning disease duration, acute pain and quality of life of the affected patients and at a reduction of the incidence of postherpetic neuralgia and other complications. The guideline development followed a structured and predefined process, considering the quality criteria for guidelines development as suggested by the AGREE II instrument. The steering group was responsible for the planning and the organization of the guideline development process (Division of Evidence based Medicine, dEBM). The expert panel was nominated by virtue of clinical expertise and/or scientific experience and included experts from the fields of dermatology, virology/infectiology, ophthalmology, otolaryngology, neurology and anaesthesiology. Recommendations for clinical practice were formally consented during the consensus conference, explicitly considering different relevant aspects. The guideline was approved by the commissioning societies after an extensive internal and external review process. In this first part of the guideline, diagnostic means have been evaluated. The expert panel formally consented recommendations for the management of patients with (suspected) HZ, referring to the assessment of HZ patients, considering various specific clinical situations. Users of the guideline must carefully check whether the recommendations are appropriate for the context of intended application. In the setting of an international guideline, it is generally important to consider different national approaches and legal circumstances with regard to the regulatory approval, availability and reimbursement of diagnostic and therapeutic interventions. [less ▲]

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See detailFirst Report of Candidatus Liberibacter solanacearum Associated with the Psyllid Bactericera trigonica Hodkinson on Carrots in Northern Africa
Tahzima, R.; Massart, Sébastien ULiege; Achbani, E.H. et al

in Plant Disease (2017), 101(1), 242

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See detailAttention et simultanéité intellectuelle chez Descartes, Clauberg et Spinoza
Dubouclez, Olivier ULiege

in Les études philosophiques (2017), 1

Abstract. – is paper deals with a classical problem, can we think or apprehend many things at once ? as it was understood and solved by Descartes and its followers. e idea that we can apprehend di erent ... [more ▼]

Abstract. – is paper deals with a classical problem, can we think or apprehend many things at once ? as it was understood and solved by Descartes and its followers. e idea that we can apprehend di erent ideas at once is central in Descartes’ theory of knowledge, especially in the Rules, and it relies on the claim that attention can be divided between two objects or ideas. Clauberg considers on the contrary that the imagination alone can graps things simultaneously and holds the living body as the true paradigm of simultaneous activity. Spinoza has a synthetic point of view : simultaneity within the body and the mind are expressions of the power of the individ- ual and of his develoment. Attention is no more a condition of intellectual simultaneity, as in Descartes, but is rather an obstacle which needs to be overcome to reach a richer and better understanding of reality. [less ▲]

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See detailLa polémique marxiste comme pouvoir de praxis : le rôle des revues dans la radicalisation d'un imaginaire politique
Franck, Thomas ULiege

in Dacoromania Litteraria (2017), 3

On the basis of Antonio Gramsci’s praxis philosophy, taken up by André Tosel, and Cornelius Castoriadis’ works on radical imaginary, this article analyses the debate about Marxism, during the year 1946 ... [more ▼]

On the basis of Antonio Gramsci’s praxis philosophy, taken up by André Tosel, and Cornelius Castoriadis’ works on radical imaginary, this article analyses the debate about Marxism, during the year 1946, between two intellectual reviews: Les Temps Modernes and Critique. If the creation of those reviews is deeply related to a social context and an interdiscourse influenced by the political and ideological rise of extreme left – particularly the French Communist Party –, their project consists in a critical questioning of communist discourses, returning to Marx’s and Hegel’s texts. References to these philosophies induce different rhetorical and argumentative particularities that we intend to study in order to understand the complex relations between the rhetoric of a sociohistorical interdiscourse and his ideological substructure. [less ▲]

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See detailDetection, isolation and characterization of Fusobacterium gastrosuis sp. nov. colonizing the stomach of pigs
De Witte, C.; Flahou, B.; Ducatelle, R. et al

in Systematic & Applied Microbiology (2017), 40(1), 42-50

Nine strains of a novel Fusobacterium sp. were isolated from the stomach of 6-8 months old and adult pigs. The isolates were obligately anaerobic, although they endured 2 hours exposure to air ... [more ▼]

Nine strains of a novel Fusobacterium sp. were isolated from the stomach of 6-8 months old and adult pigs. The isolates were obligately anaerobic, although they endured 2 hours exposure to air. Phylogenetic analysis based on 16S rRNA and gyrase B genes demonstrated that the isolates showed high sequence similarity with Fusobacterium mortiferum, Fusobacterium ulcerans, Fusobacterium varium, Fusobacterium russii and Fusobacterium necrogenes, but formed a distinct lineage in the genus Fusobacterium. Comparative analysis of the genome of the type strain of this novel Fusobacterium sp. confirmed that it is different from other recognized Fusobacterium spp. DNA-DNA hybridization, fingerprinting and genomic %GC determination further supported the conclusion that the isolates belong to a new, distinct species. The isolates were also distinguishable from these and other Fusobacterium spp. by phenotypical characterization. The strains produced indole and exhibited proline arylamidase and glutamic acid decarboxylase activity. They did not hydrolyse esculin, did not exhibit pyroglutamic acid arylamidase, valine arylamidase, α-galactosidase, β-galactosidase, β-galactosidase-6-phosphate or α-glucosidase activity nor produced acid from cellobiose, glucose, lactose, mannitol, mannose, maltose, raffinose, saccharose, salicin or trehalose. The major fatty acids were C16 : 0 and C18 : 1ω9c. The name Fusobacterium gastrosuis sp. nov. is proposed for the novel isolates with the type strain CDW1(T) (= DSM 101753(T) = LMG 29236(T)). We also demonstrated that Clostridium rectum and Fusobacterium mortiferum represent the same species, with nomenclatural priority for the latter. [less ▲]

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See detailInfluence of the balls kinematics of axially loaded ball bearings on Coulombic frictional dissipations
Bozet, Jean-Luc ULiege; Servais, Christophe ULiege

in Journal of Tribology (2017), 139(1),

Ball bearings have been used for a long time. Nevertheless, the description of their behavior remains incomplete in spite of the large number of surveys dedicated to ball bearings. Particularly, the exact ... [more ▼]

Ball bearings have been used for a long time. Nevertheless, the description of their behavior remains incomplete in spite of the large number of surveys dedicated to ball bearings. Particularly, the exact balls kinematics has still to be addressed in depth. This paper proposes a new way to calculate the balls kinematics by using a simplified quasi-static approach for dry lubricated and axially loaded ball bearings. This method does not use the classical restrictive race control assumptions. More specifically, the role played by the balls kinematics is emphasized by means of the power dissipated within contacts between balls and races. The need for a correct evaluation of the balls behavior is illustrated by using an example, viz. a ball bearing of cryogenic engine turbopump. Indeed, the dissipated power is one of the main concerns in this particular case. [less ▲]

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See detailA Machine Learning-Based Approximation of Strong Branching
Marcos Alvarez, Alejandro ULiege; Louveaux, Quentin ULiege; Wehenkel, Louis ULiege

in INFORMS Journal on Computing (2017), 29(1), 185-195

We present in this paper a new generic approach to variable branching in branch-and-bound for mixed- integer linear problems. Our approach consists in imitating the decisions taken by a good branching ... [more ▼]

We present in this paper a new generic approach to variable branching in branch-and-bound for mixed- integer linear problems. Our approach consists in imitating the decisions taken by a good branching strategy, namely strong branching, with a fast approximation. This approximated function is created by a machine learning technique from a set of observed branching decisions taken by strong branching. The philosophy of the approach is similar to reliability branching. However, our approach can catch more complex aspects of observed previous branchings in order to take a branching decision. The experiments performed on randomly generated and MIPLIB problems show promising results. [less ▲]

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See detailGoat breeding in the rural district of Chemini (Algeria)
Moula, Nassim ULiege; Ait Kaki, Asma; Touazi, Leghel et al

in Nature & Technology (2017), n° 16/Janvier

The Kabyle goat breed represents 10.52% of the total Algerian market (3.8 million heads). A survey of 69 farmers has been carried out in order to characterize it and its breeding in the District of ... [more ▼]

The Kabyle goat breed represents 10.52% of the total Algerian market (3.8 million heads). A survey of 69 farmers has been carried out in order to characterize it and its breeding in the District of Chemini. The questions focused on household agricultural activities, including breeding of goats, cattle, sheep, rabbits, chicken, turkeys, honeybees and the production of olive oil and figs. The goat morpho-biometric characterization was based on 18 corporal measurements. The Hierarchical Cluster Analysis (HCA) of the farm structures defined four groups of farms, variance between groups accounting for 55.7% of total variability. The average number of goats in groups 1 to 4 was 7.2±2.8, 11.1±3.5, 22.3±1.4 and 3.4±1.0, respectively. Group 3 (n=6), showed the greatest number; it consists of older farmers (67 years old or over) not practicing arboriculture. They also have the largest numbers of sheep (48.67), rabbits (50.83), chicken (48.33) and turkeys (42). Group 4 (n=9), with the lowest number of goats, was the group of young farmers (39 years old or less), more dedicated to cattle breeding (~52 heads) and the production of olive oil (~207 trees) and figs (~47 trees). The 18 morpho-biometric variables were significantly higher in males than in females (p<0.05). The Kabyle goat is small (Height at withers: male: 68.23±0.97cm and female: 65.41±0.55cm) with long hair (male: 12.24±0.51cm, and female: 9.51±0.29cm). Its ears are drooping, its convex profile has a slightly pronounced nasal split and its dress color ranges from dark brown to black. This adapted genetic resource should be key in the development of a local production, based on a strong commitment of farmers inside a breed association, for the production of specimens corresponding to a standard, to be determined collectively. [less ▲]

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See detailOral contraceptive and acute intestinal ischemia with mesenteric venous thrombosis: a case report
BELIARD, Aude ULiege; VERRETH, Lucie; GRANDJEAN, Pascale

in Open Access Journal of Contraception (2017), 8

Background: Venous thrombosis is a serious complication of combined contraceptive. However, mesenteric venous thrombosis and intestinal necrosis are infrequently seen in women using oral contraceptives ... [more ▼]

Background: Venous thrombosis is a serious complication of combined contraceptive. However, mesenteric venous thrombosis and intestinal necrosis are infrequently seen in women using oral contraceptives and diagnosis is often delayed. Case presentation: We report a case of a 38-year-old obese female patient who presented with acute abdominal pain. A bowel infection was first diagnosed and treated with antibiotics. Contrast-enhanced tomography of the abdomen revealed diffuse ischemia of small intestine with superior mesenteric thrombosis. Laparotomy with segmental resection of both small and large bowel was performed. No predisposing factor of mesenteric venous thrombosis was demonstrated except association of combined contraceptive with obesity. Conclusion: This report highlights the need for clinicians to suspect venous mesenteric thrombosis in women of reproductive age with acute abdominal pain with poor physical findings. Detailed personal history including prescriptions should help to quickly and accurately determine the problem. [less ▲]

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See detailThe design and study of new Li-ion full cells of LiCo2/3Ni1/6Mn1/6O2 positive electrode paired with MnSn2 and Li4Ti5O12 negative electrodes
Mahmoud, Abdelfattah ULiege; Saadoune, Ismael; Lippens, Pierre-Emmanuel et al

in Solid State Ionics (2017), 300

We report evidence for the electrochemical performances of two Li-ion full cells, built up by the combination of LiCo2/3Ni1/6Mn1/6O2 cathode material with MnSn2 intermetallic and Li4Ti5O12 spinel as the ... [more ▼]

We report evidence for the electrochemical performances of two Li-ion full cells, built up by the combination of LiCo2/3Ni1/6Mn1/6O2 cathode material with MnSn2 intermetallic and Li4Ti5O12 spinel as the anode materials, respectively. MnSn2 and Li4Ti5O12 electrode materials illustrate different working voltage versus the redox couple Li+/Li0 and different reactionmechanisms during lithiuminsertion/deinsertion cycles. The structure,morphological characteristics and the electrochemical properties of the studied materialswere investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and electrochemical techniques. The two full-cell configurations showed different electrochemical behaviors. The MnSn2//LiCo2/3Ni1/6Mn1/6O2 configuration exhibits high working voltage (~3.5 V) and specific capacity (~200 mAh/gcathode) but suffers from high irreversible capacity loss during the first cycles and capacity fading during cycling. The Li4Ti5O12//LiCo2/3Ni1/6Mn1/6O2 cell demonstrated excellent cycling properties at different C-rates with 100% capacity retention after 150 cycles at 1 C. Although the working voltage (~2.2 V) and the specific capacity (~140 mAh/gcathode) are lower than those of the MnSn2//LiCo2/3Ni1/6Mn1/6O2 configuration, the other measured electrochemical properties suggest that the Li4Ti5O12//LiCo2/3Ni1/6Mn1/6O2 full cell is a potential candidate for battery application due to its excellent cycling performance and improved safety. [less ▲]

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See detailLooking for phosphate-accumulating bacteria in activated sludge processes : a multidisciplinary approach
Tarayre, Cédric ULiege; Charlier, Raphaëlle; Delepierre, Anissa ULiege et al

in Environmental Science and Pollution Research (2017)

Over the past decades, an increasing need in renewable resources has progressively appeared. This trend concerns not only fossil fuels but also mineral resources. Wastewater and sewage sludge contain ... [more ▼]

Over the past decades, an increasing need in renewable resources has progressively appeared. This trend concerns not only fossil fuels but also mineral resources. Wastewater and sewage sludge contain significant concentrations in phosphate and can be considered as a fertilizer source of the utmost importance. In wastewater treatment plants, the biological uptake of phosphate is performed by a specific microbiota: the phosphate-accumulating organisms. These microorganisms are recovered in sewage sludge. Here, we aimed to investigate the occurrence of phosphate accumulators in four wastewater treatment plants. A 16S metagenetic analysis identified the main bacterial phyla extracted from the aerobic treatment: α-Proteobacteria, β-Proteobacteria, and Sphingobacteria. An enrichment stage was performed to stimulate the specific growth of phosphate-accumulating bacteria in an acetate medium. An analysis of metabolic activities of sulfur and phosphorus highlighted strong modifications related to phosphorus and much less distinguishable effects with sulfur. A solid acetate medium containing 5-Br-4-Cl-3-indolyl phosphate was used to select potential phosphate-accumulating bacteria from the enriched consortia. The positive strains have been found to belong in the genera Acinetobacter, Corynebacterium, and Pseudomonas. Finally, electron microscopy was applied to the strains and allowed to confirm the presence of polyphosphate granules. Some of these bacteria contained granules the size of which exceeded 100 nm. [less ▲]

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See detailSofosbuvir in Combination with Simeprevir +/- Ribavirin in Genotype 4 Hepatitis C Patients with Advanced Fibrosis or Cirrhosis: A Real-World Experience from Belgium
Degré, D; Sersté, T; Lasser, L et al

in PLoS ONE (2017), 12(1), 0170933

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See detailHow cognition affects perception: Brain activity modelling to unravel top-down dynamics
Desseilles, Martin ULiege; Phillips, Christophe ULiege

in Behavioral and Brain Sciences (2017), 39

In this commentary on Firestone & Scholl's (F&S's) article, we argue that researchers should use brain-activity modelling to investigate top-down mechanisms. Using functional brain imaging and a specific ... [more ▼]

In this commentary on Firestone & Scholl's (F&S's) article, we argue that researchers should use brain-activity modelling to investigate top-down mechanisms. Using functional brain imaging and a specific cognitive paradigm, modelling the BOLD signal provided new insight into the dynamic causalities involved in the influence of cognitions on perceptions. [less ▲]

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See detailSpatial variation in the accumulation of POPs and mercury in bottlenose dolphins of the Lower Florida Keys and the coastal Everglades (South Florida)
Damseaux, France ULiege; Kiszka, J.; Heithaus, M.R. et al

in Environmental Pollution (2017), 220

The bottlenose dolphin (Tursiops truncatus) is an upper trophic level predator and the most common cetacean species found in nearshore waters of southern Florida, including the Lower Florida Keys (LFK ... [more ▼]

The bottlenose dolphin (Tursiops truncatus) is an upper trophic level predator and the most common cetacean species found in nearshore waters of southern Florida, including the Lower Florida Keys (LFK) and the Florida Coastal Everglades (FCE). The objective of this study was to assess contamination levels of total mercury (T-Hg) in skin and persistent organic pollutants (PCBs, PBDEs, DDXs, HCHs, HCB, Σ PCDD/Fs and Σ DL-PCBs) in blubber samples of bottlenose dolphins from LFK (n = 27) and FCE (n = 24). PCBs were the major class of compounds found in bottlenose dolphin blubber and were higher in individuals from LFK (Σ 6 PCBs LFK males: 13421 ± 7730 ng.g-1 lipids, Σ 6 PCBs LFK females: 9683 ± 19007 ng.g-1 lipids) than from FCE (Σ 6 PCBs FCE males: 5638 ng.g-1 ± 3627 lipids, Σ 6 PCBs FCE females: 1427 ± 908 ng.g-1 lipids). These levels were lower than previously published data from the southeastern USA. The Σ DL-PCBs were the most prevalent pollutants of dioxin and dioxin like compounds (Σ DL-PCBs LFK: 739 ng.g-1 lipids, Σ DL-PCBs FCE: 183 ng.g-1 lipids) since PCDD/F concentrations were low for both locations (mean 0.1 ng.g-1 lipids for LFK and FCE dolphins). The toxicity equivalences of PCDD/Fs and DL-PCBs expressed as TEQ in LFK and FCE dolphins is mainly expressed by DL-PCBs (81% LFK - 65% FCE). T-Hg concentrations in skin were significantly higher in FCE (FCE median 9314 ng.g-1 dw) compared to LFK dolphins (LFK median 2941 ng.g-1 dw). These bottlenose dolphins concentrations are the highest recorded in the southeastern USA, and may be explained, at least partially, by the biogeochemistry of the Everglades and mangrove sedimentary habitats that create favourable conditions for the retention of mercury and make it available at high concentrations for aquatic predators. [less ▲]

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See detailHabitat selection by marine larvae in changing chemical environments
Lecchini, David; Dixson, Danielle L.; Lecellier, Gael et al

in Marine Pollution Bulletin (2017), 114

The replenishment and persistence of marine species is contingent on dispersing larvae locating suitable habitat and surviving to a reproductive stage. Pelagic larvae rely on environmental cues to make ... [more ▼]

The replenishment and persistence of marine species is contingent on dispersing larvae locating suitable habitat and surviving to a reproductive stage. Pelagic larvae rely on environmental cues to make behavioural decisions with chemical information being important for habitat selection at settlement. We explored the sensory world of crustaceans and fishes focusing on the impact anthropogenic alterations (ocean acidification, red soil, pesticide) have on conspecific chemical signals used by larvae for habitat selection. Crustacean (Stenopus hispidus) and fish (Chromis viridis) larvae recognized their conspecifics via chemical signals under control conditions. In the presence of acidified water, red soil or pesticide, the ability of larvae to chemically recognize conspecific cues was altered. Our study highlights that recruitment potential on coral reefs may decrease due to anthropogenic stressors. If so, populations of fishes and crustaceans will continue their rapid decline; larval recruitment will not replace and sustain the adult populations on degraded reefs. [less ▲]

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See detailSilicate mineralogy at the surface of Mercury
Namur, Olivier ULiege; Charlier, Bernard ULiege

in Nature Geoscience (2017)

NASA’s MESSENGER spacecraft has revealed geochemical diversity across Mercury’s volcanic crust. Near-infrared to ultraviolet spectra and images have provided evidence for the Fe2+-poor nature of silicate ... [more ▼]

NASA’s MESSENGER spacecraft has revealed geochemical diversity across Mercury’s volcanic crust. Near-infrared to ultraviolet spectra and images have provided evidence for the Fe2+-poor nature of silicate minerals, magnesium sulfide minerals in hollows and a darkening component attributed to graphite, but existing spectral data is insufficient to build a mineralogical map for the planet. Here we investigate the mineralogical variability of silicates in Mercury’s crust using crystallization experiments on magmas with compositions and under reducing conditions expected for Mercury. We find a common crystallization sequence consisting of olivine, plagioclase, pyroxenes and tridymite for all magmas tested. Depending on the cooling rate, we suggest that lavas on Mercury are either fully crystallized or made of a glassy matrix with phenocrysts. Combining the experimental results with geochemical mapping, we can identify several mineralogical provinces: the Northern Volcanic Plains and Smooth Plains, dominated by plagioclase, the High-Mg province, strongly dominated by forsterite, and the Intermediate Plains, comprised of forsterite, plagioclase and enstatite. This implies a temporal evolution of the mineralogy from the oldest lavas, dominated by mafic minerals, to the youngest lavas, dominated by plagioclase, consistent with progressive shallowing and decreasing degree of mantle melting over time. [less ▲]

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See detailLe castor, porte-parole d'une rivière vivante
Denayer, Dorothée ULiege; Semal, Nathalie ULiege

in Mille Lieux (2017), 4

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See detailReversible TAD chemistry as a convenient tool for the design of (re)processable PCL-based shape-memory materials
Defize, Thomas ULiege; Riva, Raphaël ULiege; Thomassin, Jean-Michel ULiege et al

in Macromolecular Rapid Communications (2017), 38(1), 1600517

A chemically cross-linked but remarkably (re)processable shape-memory polymer (SMP) is designed by cross-linking poly(ε -caprolactone) (PCL) stars via the efficient triazolinedione click chemistry, based ... [more ▼]

A chemically cross-linked but remarkably (re)processable shape-memory polymer (SMP) is designed by cross-linking poly(ε -caprolactone) (PCL) stars via the efficient triazolinedione click chemistry, based on the very fast and reversible Alder– ene reaction of 1,2,4-triazoline-3,5-dione (TAD) with indole compounds. Typically, a six-arm star-shaped PCL function- alized by indole moieties at the chain ends is melt-blended with a bisfunctional TAD, directly resulting in a cross-linked PCL-based SMP without the need of post-curing treatment. As demonstrated by the stress relaxation measurement, the labile character of the TAD–indole adducts under stress allows for the solid-state plasticity reprocessing of the permanent shape at will by compression molding of the raw cross-linked material, while keeping excellent shape-memory properties. [less ▲]

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See detailNo copper required for germination of an endangered endemic species from the Katangan Copperbelt (Katanga, DR Congo): Diplolophium marthozianum
Boisson, Sylvain ULiege; Ortmans, William ULiege; Maréchal, Justine et al

in Tropical Ecology (2017), 58(1), 193-198

Two hypotheses were tested with respect to the germination of Diplolophium marthozianum, an endemic plant species of the copper-cobalt outcrops in Katanga, Democratic Republic of Congo: (1) germination of ... [more ▼]

Two hypotheses were tested with respect to the germination of Diplolophium marthozianum, an endemic plant species of the copper-cobalt outcrops in Katanga, Democratic Republic of Congo: (1) germination of copper-endemics is limited by fungal infection in the absence of pathogen control and (2) the germination success of this copper-endemic species is copper-dependent. Seed lots of twenty seeds were weighed, soaked in different disinfection treatments and then placed in a germination medium containing four distinct copper concentrations for 30 days. Seed viability was measured at the beginning and at the end of the experiment by a cut test. Final germination percentage (15.2 ± 8.2 %) and seed viability (24.2 ± 10.3 %) were not affected by copper concentration or disinfection treatments. D. marthozianum is able to germinate in a substrate without added copper, despite pervasive fungal infection. However, seed mass had a significant positive effect on seed germination suggesting that selecting the largest seeds may ensure the highest germination success in ex situ conservation programs. [less ▲]

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See detailThe Role of Companies in Smart City Initiatives: The Case of Belgium
Andre, Anne-Marie; Crutzen, Nathalie ULiege

in Economia (2017)

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See detailCompte-rendu de l'ouvrage de Robert Ford et Bob McGrath : ZYDECO DISCOGRAPHY 1949-2010
Sacré, Robert ULiege

in ABS Magazine (2017), (53),

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See detailLinking pollutant exposure of humpback whales breeding in the Indian Ocean to their feeding habits and feeding areas off Antarctica
Das, Krishna ULiege; Malarvannan, Govindan; Dirtu, Alin et al

in Environmental Pollution (2017), 220

Humpback whales, Megaptera novaeangliae, breeding off la Reunion Island (Indian Ocean) undergo large-scale seasonal migrations between summer feeding grounds near Antarctica and their reproductive winter ... [more ▼]

Humpback whales, Megaptera novaeangliae, breeding off la Reunion Island (Indian Ocean) undergo large-scale seasonal migrations between summer feeding grounds near Antarctica and their reproductive winter grounds in the Indian Ocean. The main scope of the current study was to investigate chemical exposure of humpback whales breeding in the Indian Ocean by providing the first published data on this breeding stock concerning persistent organic pollutants (POPs), namely polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), hexachlorocyclohexanes (HCHs), DDT and its metabolites (DDTs), chlordane compounds (CHLs), polybrominated diphenyl ethers (PBDEs), and methoxylated PBDEs (MeO-PBDEs). Analyses of stable isotopes δ13C and δ15N in skin resulted in further insight in their feeding ecology, which was in agreement with a diet focused mainly on low trophic level prey species, such as krill from Antarctica. POPs were measured in all humpback whales in the order of HCB > DDTs > CHLs > HCHs > PCBs > PBDEs > MeO-BDEs. HCB (median: 24 ng.g-1 lw) and DDTs (median: 7.7 ng.g-1 lw) were the predominant compounds in all whale biopsies. Among DDT compounds, p,p’-DDE was the major organohalogenated pollutant, reflecting its long-term accumulation in humpback whales. Significantly lower concentrations of HCB and DDTs were found in females than in males (p<0.001). Other compounds were similar between the two genders (p>0.05). Differences in the HCB and DDTs suggested gender-specific transfer of some compounds to the offspring. POP concentrations were lower than previously reported results for humpback whales sampled near the Antarctic Peninsula, suggesting potential influence of their nutritional status and may indicate different exposures of the whales according to their feeding zones. Further investigations are required to assess exposure of southern humpback whales throughout their feeding zones. [less ▲]

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See detailEtude rétrospective du bilan thyroïdien: définition de valeurs de référence pédiatriques
LADANG, Aurélie ULiege; VRANKEN, Laura ULiege; LUYCKX, Françoise ULiege et al

in Revue Médicale de Liège (2017)

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range ... [more ▼]

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range for TSH, FT3 and FT4 for Cobas C6000 analyzer. To do so, we have taken in account 0 to 18 year old outclinic patients. During the first year of life, thyroid hormone levels change dramatically before getting stabilized around 3 years old. We also compared our results to those obtained in a Canadian large-scale prospective study (the CALIPER initiative). [less ▲]

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See detailPrésentation
Dubouclez, Olivier ULiege; Pelletier, Arnaud

in Etudes Philosophiques (Les) (2017), n°1(2017), 3-5

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See detailExploring Metacognition as Support for Learning Transfer
Scharff, Lauren; Draeger, John; Verpoorten, Dominique ULiege et al

in Teaching & Learning Inquiry: The ISSoTL Journal (2017), 5(1),

The ability to transfer learning to new situations lies at the heart of lifelong learning and the employability of university graduates. Because students are often unaware of the importance of learning ... [more ▼]

The ability to transfer learning to new situations lies at the heart of lifelong learning and the employability of university graduates. Because students are often unaware of the importance of learning transfer and staff do not always explicitly articulate this expectation, this article explores the idea that metacognition (intentional awareness and the use of that awareness) might enhance the development of learning transfer. Our exploratory study includes results from a survey of 74 staff and 118 students from five institutions in Australia, Belgium, UK, and USA. Our data indicate that many staff and a majority of students do not have a clear understanding of what learning transfer entails, and that there are many mismatches between staff and student perceptions, attitudes, and behaviors regarding learning transfer. This helps explain why learning transfer does not occur as often as it could. We found significant positive correlations between thinking about transfer and thinking about learning processes and the likelihood to use awareness of metacognition to guide practice. Our findings suggest a positive relationship between metacognition and learning transfer. Implications for scholarship of teaching and learning are discussed. [less ▲]

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See detailMulti-approach analysis to assess diet of harbour porpoises Phocoena phocoena in the southern North Sea
Mahfouz, C.; Meziane, T.; Henry, F. et al

in Marine Ecology. Progress Series (2017), 563

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See detailInvited Commentary
Lancellotti, Patrizio ULiege; Nchimi Longang, Alain ULiege

in Annals of Thoracic Surgery (2017), 103(1), 81-82

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See detailCompte rendu: AXEMAN's JAZZ et DEAD MAN'S BLUES ( Ray Celestin)
Sacré, Robert ULiege

in ABS Magazine (2017), (53),

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See detailLearning from Incidents and Incident Reporting: Safety Governance at a Belgian Nuclear Research Center
Rossignol, Nicolas ULiege; Van Oudheusden, Michiel ULiege

in Science, Technology & Human Values (2017), 42

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews ... [more ▼]

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews and focus groups with personnel, it illustrates how REX enacts a safety governmentality centered on identifying incident causes and culprits. As this governmentality mode obscures the epistemic and political character of incidents, it closes down important opportunities for collective learning about safety and safety governance. It is argued that joint reflection about incidents and resistances towards incident reporting serve as fruitful starting points for a more reflexive safety governance that makes explicit how decisions are made in high-risk contexts. Social scientists can enhance governance of this kind by pointing to different perceptions and evaluations of incidents and by insisting that contending interpretations are confronted and accounted for. [less ▲]

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See detailMemory consolidation in children with Specific Language Impairment: Delayed gains and susceptibility to interference in implicit sequence learning
Desmottes, Lise ULiege; Maillart, Christelle ULiege; Meulemans, Thierry ULiege

in Journal of Clinical and Experimental Neuropsychology (2017)

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language ... [more ▼]

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language impairment (SLI). Two aspects of memory consolidation in implicit sequence learning were examined: the evolution of post-training gains in sequence knowledge (Experiment 1) and the susceptibility to interference (Experiment 2). Method and Results: In the first experiment, 18 children with SLI and 17 control children matched for sex, age, and nonverbal intelligence completed a serial reaction-time (SRT) task and were tested 24 hours and 1 week after practicing. The two groups of children attained an equal level of sequence knowledge in the training session, but the children with SLI lacked the consolidation gains displayed by the control children in the two post-training sessions. Working with a new group of children, 17 with SLI and 17 control peers, Experiment 2 examined resistance to interference by introducing a second sequence 15 minutes after the first training session. Similar results were obtained for the performance of both groups in the training session. However, although the performance of the control group improved in the post-training sessions, the performance of the SLI group deteriorated significantly during the consolidation phase due to the interfering sequence. Conclusion: These findings suggest that the consolidation phase of sequence learning is impaired in children with SLI. [less ▲]

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See detailA water retention model for compacted bentonites
Dieudonné, Anne-Catherine ULiege; Della Vecchia, Gabriele; Charlier, Robert ULiege

in Canadian Geotechnical Journal (2017)

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See detailSystématiser les associations. Le concept hjelmslévien de paradigme et son héritage greimassien
Badir, Sémir ULiege; Cigana, Lorenzo ULiege

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017), 8

This paper aims to explore the notion of “paradigm” by following its development in the epistemology of linguistics and semiotics of the twentieth century through three landmarks: its first use within ... [more ▼]

This paper aims to explore the notion of “paradigm” by following its development in the epistemology of linguistics and semiotics of the twentieth century through three landmarks: its first use within linguistics, by Ferdinand de Saussure, its redefinition by Louis Hjelmslev, and its reinterpretation in textual semiotics by Algirdas J. Greimas. The concept of “paradigm” represents, more than others, the very target of structuralist theorisation. Marking the transition between openness and closeness of linguistic categories, it crystallises the structuralist ambition to bring the dynamic variability and richness of semiotic phenomena back to a closed, or at least stable, inventory of functional ground elements. [less ▲]

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See detailArt Nouveau in Liège : From Avant-garde to a new Eclectism
Charlier, Sébastien ULiege

in Coupdefouet (2017), 28

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See detailBehavioral fever in ectothermic vertebrates.
Rakus, Krzysztof; Ronsmans, Maygane; Vanderplasschen, Alain ULiege

in Developmental & Comparative Immunology (2017), 66

Fever is an evolutionary conserved defense mechanism which is present in both endothermic and ectothermic vertebrates. Ectotherms in response to infection can increase their body temperature by moving to ... [more ▼]

Fever is an evolutionary conserved defense mechanism which is present in both endothermic and ectothermic vertebrates. Ectotherms in response to infection can increase their body temperature by moving to warmer places. This process is known as behavioral fever. In this review, we summarize the current knowledge on the mechanisms of induction of fever in mammals. We further discuss the evolutionary conserved mechanisms existing between fever of mammals and behavioral fever of ectothermic vertebrates. Finally, the experimental evidences supporting an adaptive value of behavioral fever expressed by ectothermic vertebrates are summarized. [less ▲]

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See detailTransdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.
Sergeant, Camille; Jublanc, Christel; Leclercq, Delphine et al

in American Journal of Surgical Pathology (2017)

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a ... [more ▼]

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed. [less ▲]

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See detailExposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Sabatel, Catherine ULiege; Radermecker, Coraline ULiege; Fievez, Laurence ULiege et al

in Immunity (2017), 46(3), 457-473

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major ... [more ▼]

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow. Using a mouse model of allergic airway inflammation, we found that adoptive transfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. IM-mediated protection was dependent on IL-10, given that Il10-/- CpG-induced IMs lacked regulatory effects. Thus, the expansion of regulatory lung IMs upon exposure to CpG might underlie the reduced risk of asthma development associated with a microbe-rich environment. [less ▲]

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See detailFactors controlling spatial and temporal patterns of multiple pesticide compounds in groundwater (Hesbaye chalk aquifer, Belgium)
Hakoun, Vivien; Orban, Philippe ULiege; Dassargues, Alain ULiege et al

in Environmental Pollution (2017)

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To ... [more ▼]

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To uncover which factors govern pesticide compound concentrations in a chalk aquifer, we develop a methodology based on time series analyses, uni- and multivariate statistics accounting for concentrations below detection limits. The methodology is applied to long records (1996–2013) of a restricted compound (bentazone), three banned compounds (atrazine, diuron and simazine) and two metabolites (deethylatrazine (DEA) and 2,6–dichlorobenzamide (BAM)) sampled in the Hesbaye chalk aquifer in Belgium. In the confined area, all compounds had non-detects fractions >80%. By contrast, maximum concentrations exceeded EU’s drinking-water standard (100 ngL-1) in the unconfined area. This contrast confirms that recent recharge and polluted water did not reach the confined area, yet. Multivariate analyses based on variables representative of the hydrogeological setting revealed higher diuron and simazine concentrations in the southeast of the unconfined area, where urban activities dominate land use and where the aquifer lacks protection from a less permeable layer of hardened chalk. At individual sites, positive correlations (up to τ =0,48 for bentazone) between pesticide compound concentrations and multi-annual groundwater level fluctuations confirm occurrences of remobilization. A downward temporal trend of atrazine concentrations likely reflects decreasing use of this compound over the last 28 years. However, the lack of a break in concentrations time series and maximum concentrations of atrazine, simazine, DEA and BAM exceeding EU’s standard post-ban years provide evidence of persistence. Contrasting upward trends in bentazone concentrations show that a time lag is required for restriction measures to be efficient. These results shed light on factors governing pesticide compound concentrations in chalk aquifers. The developed methodology is not restricted to chalk aquifers, it could be transposed to study other pollutants with concentrations below detection limits. Several factors govern pesticide compounds concentrations in the chalk: hydrogeological setting, land use, groundwater level fluctuations and persistence. [less ▲]

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See detailRigid catheters reduced duration of less invasive surfactant therapy procedures in manikins.
RIGO, Vincent ULiege; Debauche, Christian; Maton, Pierre et al

in Acta Paediatrica (2017)

Aim: Different catheters can be used for less invasive surfactant therapy (LIST): feeding tubes inserted with or without Magill forceps, different angiocatheters and centre specific devices, such as ... [more ▼]

Aim: Different catheters can be used for less invasive surfactant therapy (LIST): feeding tubes inserted with or without Magill forceps, different angiocatheters and centre specific devices, such as umbilical catheters affixed to a stylet. This study compared the effectiveness of LIST devices and endotracheal tubes (ETT). Methods: Video recordings of 20 neonatologists simulating different LIST techniques on two manikin heads were analysed. Procedural effectiveness was evaluated by the duration of procedures and failure rates. Ease of use was scored. Results: The median procedure time for the Neonatal Intubation Trainer was significantly longer with feeding tubes without Maggil forceps. For the more difficult ALS Baby Trainer, successful procedures lasted a median of 24 (17-32) seconds with ETT, 24 (15-36) seconds with stylet-guided catheters and 34 (27-46) seconds and 37 (29-42) seconds with 13cm and 30cm angiocatheters, respectively. Both methods using feeding tubes were statistically slower than ETT intubation, lasting 32 (25-44) seconds and 39 (27-95) seconds with or without Maggil forceps. Failure rates (7-20%) were no different between the LIST methods. Techniques using feeding tubes were rated as more difficult. Conclusion: Only rigid or stylet-guided catheters required tracheal catheterisation times similar to those of endotracheal intubation and neonatologists found them easier.  KEY NOTES • This manikin study used video recordings of 20 neonatologists to compare the effectiveness of devices for less invasive surfactant therapy (LIST) and endotracheal tubes. • The durations of tracheal catheterisation for LIST using rigid or stylet-guided catheters were no different from those obtained with endotracheal tubes, but feeding tubes with or without Maggil forceps required longer procedures. • Neonatologists found rigid or stylet-guided catheters easier to use. [less ▲]

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See detailPostembryonic development of appendicular and axial skeletons in Labeo parvus (Cyprinidae)
Lederoun, Djiman; Montchowui, Elie; Lalèyè, Philippe et al

in Cybium (2017), 41(1), 3-10

The axial and appendicular skeletons in Labeo parvus (Cyprinidae) were investigated from hatching to 29 days post-hatch (dph) in cleared and stained specimens. The cartilaginous axial caudal skeleton of L ... [more ▼]

The axial and appendicular skeletons in Labeo parvus (Cyprinidae) were investigated from hatching to 29 days post-hatch (dph) in cleared and stained specimens. The cartilaginous axial caudal skeleton of L. parvus develops like in other cyprinids. The first cartilaginous elements, namely hypurals I and II, appeared 6 dph before notochord flexion. Ossification of the complex begins with that of caudal rays on day 10, next the vertebral bodies, and then all the hypurals on day 14. Dorsal fin development is quite comparable to that of the anal fin. Cartilaginous structures (proximal and distal pterygiophores) appear on day 14 in both fins. Ossification of both fins starts with the rays on day 14, then with the anterior pterygiophores on day 19. Examination of the axial skeleton shows that cartilaginous structures, namely basidorsals and basiventrals, arise on day 14 while ossification begins with the anterior vertebral structures on day 10. [less ▲]

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See detailPolyurethane coatings in 20th century outdoor painted sculptures. Part I: Comparative study of various systems by means of ATR-FTIR spectroscopy
Defeyt, Catherine ULiege; Langenbacher, Julia; Rivenc, Rachel

in Heritage Science (2017), 5

Like acrylics and alkyds, polyurethanes (PUs) represent an important class of industrial paints adopted by 20th and 21st artists; primarily by those creating outdoor painted sculptures (OPS). Because PU ... [more ▼]

Like acrylics and alkyds, polyurethanes (PUs) represent an important class of industrial paints adopted by 20th and 21st artists; primarily by those creating outdoor painted sculptures (OPS). Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of paints, they are commonly recognized as the most appropriate option for painted artworks intended for an outdoor setting. However, the PU class includes various systems and subgroups possessing very different properties. Through the FTIR-ATR study of 137 PU coating references from the Getty Conservation Institute (GCI) reference collection, this paper outlines the differences and the similarities existing, in terms of the composition, of two package solvent-borne, two package water-borne, one package water-borne and fluoropolymer polyurethanes. The comparison of the obtained FTIR-ATR results allowed determining markers helpful to discriminate specific PU subgroups by means of ATR-FTIR spectroscopy. The goals of this paper are to provide to the conservation professionals a better understanding of the versatility and diversity of PU coatings and to facilitate the identification of the various types initially used by the artists. [less ▲]

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See detailQuality of life assessment in musculo-skeletal health
Beaudart, Charlotte ULiege; Biver, Emmanuel; Bruyère, Olivier ULiege et al

in Aging Clinical and Experimental Research (2017), (Online First),

Musculoskeletal disorders affect morbidity, quality of life and mortality, and represent an increasing economic and societal burden in the context of population aging and increased life expectancy ... [more ▼]

Musculoskeletal disorders affect morbidity, quality of life and mortality, and represent an increasing economic and societal burden in the context of population aging and increased life expectancy. Improvement of quality of life should be one of the priorities of any interventions to prevent and treat musculoskeletal disorders in the ageing population. Two main approaches, namely generic and disease-specific instruments, can be applied to measure health-related quality of life. Among the generic tools available in scientific literature, the short form 36 questionnaire (SF-36) and the Euroqol five item questionnaire (EQ-5D) are two of the most popular questionnaires used to quantify the health related quality of life in people with musculoskeletal disorders. However, because generic tools may not always be able to detect subtle effects of a specific condition on quality of life, a specific tool is highly valuable. Specific tools improve the ability to clinically characterize quality of life in subjects with a specific musculoskeletal disorder, as well as the capacity to assess changes over time in the QoL of these subjects. The recent development of specific tools should help to validate preventive and therapeutic interventions in this field. [less ▲]

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See detailCarbon budget measurement over 12 years at a crop production site in the silty-loam region in Belgium
Buysse, Pauline; Bodson, Bernard ULiege; Debacq, Alain ULiege et al

in Agricultural and Forest Meteorology (2017), 246

Carbon dioxide (CO2) exchanges between crops and the atmosphere are influenced by both climatic and management drivers. In this study, a site at the Lonzée Terrestrial Observatory (candidate ICOS site) in ... [more ▼]

Carbon dioxide (CO2) exchanges between crops and the atmosphere are influenced by both climatic and management drivers. In this study, a site at the Lonzée Terrestrial Observatory (candidate ICOS site) in Belgium that had been managed for more than 70 years using conventional farming practices, was monitored over three complete rotation cycles (sugar beet/winter wheat/seed potato/winter wheat) from 2004 to 2016. Continuous eddy-covariance measurements and regular biomass samplings were performed in order to obtain the daily and seasonal Net Ecosystem Exchange (NEE), Gross Primary Productivity (GPP), Total Ecosystem Respiration (TER), Net Primary Productivity (NPP) and Net Biome Production (NBP). Meteorological data and crop management practices were also recorded. Over the 12 crop seasons, total NEE varied both between and within crop types. Crop type influenced net carbon (C) sequestration, with the seed potato crop exhibiting the smallest C fluxes. Despite differences in CO2 assimilation response to weather variables and in cumulated TER/GPP dynamics, the sugar beet, winter wheat and maize crops had similar seasonal NEE values. The NEE inter-annual variability, both between and within crop types, was explained mainly by the length of the active vegetation period, as well as the cumulated photosynthetic photon flux density and average air temperature during this period. The establishment of the C budget over the 12 years of study showed that NEE was a downward (negative) flux (−4.40 ± 0.05 kg C m−2), but NBP was an upward (positive) flux (0.99 ± 0.22 kg C m−2). That is, as soon as C exportation at harvest and C importation (manure, slimes) were included in the budget, the site behaved as a C source. The intercrop periods contributed significantly to the total C budget, and the C fluxes generated during these periods were positively related to crop residue amount and temperature. The largest uncertainties about the crop C budget were those relating to biomass measurements. Carrying out a soil C inventory would help to validate the NBP-based estimate of soil C loss. [less ▲]

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See detailRethinking the Memorable Panel from Pierre Sterckx to Olivier Josso Hamel
Crucifix, Benoît ULiege

in European Comic Art (2017), 10(2), 24-47

Going back to the origins of the ‘case mémorable’ in the pages of Les Cahiers de la bande dessinée, this article revisits the debates between Pierre Sterckx and Benoît Peeters, articulated around a ... [more ▼]

Going back to the origins of the ‘case mémorable’ in the pages of Les Cahiers de la bande dessinée, this article revisits the debates between Pierre Sterckx and Benoît Peeters, articulated around a conceptual tension between linear and tabular, about the relationship between single panels and narrative. It proposes that the ‘remembered panel’ pinpoints important issues about the recirculation of single images, isolated from their contexts, and the discourse of memory that becomes associated with it. A close-reading of Olivier Josso Hamel’s Au travail, in which the cartoonist redraws his own set of remembered panels, further calls for a reconsideration of Sterckx’s concept in the light of a creative practice that intimately engages with the memory of such panels in a complex relationship to their original narratives. [less ▲]

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See detailDistributed Training Enhances Implicit Sequence Acquisition in Children With Specific Language Impairment
Desmottes, Lise ULiege; Meulemans, Thierry ULiege; Patinec, Marie-Aude et al

in Journal of Speech, Language, and Hearing research (2017)

Purpose This study explored the effects of 2 different training structures on the implicit acquisition of a sequence in a serial reaction time (SRT) task in children with and without specific language ... [more ▼]

Purpose This study explored the effects of 2 different training structures on the implicit acquisition of a sequence in a serial reaction time (SRT) task in children with and without specific language impairment (SLI). Method All of the children underwent 3 training sessions, followed by a retention session 2 weeks after the last session. In the massed-training condition, the 3 training sessions were in immediate succession on 1 day, whereas in the distributed-training condition, the 3 training sessions were spread over a 1-week period in an expanding schedule format. Results Statistical analyses showed that the children with normal language were unaffected by the training conditions, performing the SRT task similarly in both training conditions. The children with SLI, however, were affected by the training structure, performing the SRT task better when the training sessions were spaced over time rather than clustered on 1 day. Conclusion This study demonstrated that although intensive training does not increase learning in children with SLI, distributing training sessions over time does increase learning. The implications of these results on the learning abilities of children with SLI are discussed, as are the mechanisms involved in massed versus distributed learning. [less ▲]

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See detailTroubles du comportement alimentaire et régulation émotionnelle
Englebert, Jérôme ULiege

in Psychosomatique Relationnelle (2017), 7

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See detailMesenchymal stromal cell therapy for inflmmatory bowel diseases
GREGOIRE, Céline ULiege; LECHANTEUR, Chantal ULiege; BRIQUET, Alexandra ULiege et al

in Alimentary Pharmacology & Therapeutics (2017), 45

Background Inflammatory bowel diseases (IBD) are chronic relapsing diseases in which pro-inflammatory immune cells and cytokines induce intestinal tissue damage and disability. Mesenchymal stromal cells ... [more ▼]

Background Inflammatory bowel diseases (IBD) are chronic relapsing diseases in which pro-inflammatory immune cells and cytokines induce intestinal tissue damage and disability. Mesenchymal stromal cells (MSCs) exert powerful immunomodulatory effects and stimulate tissue repair. Aim To review the current data on mesenchymal stromal cell therapy in IBD. Method We searched PubMed and ‘ClinicalTrials.gov’ databases using the terms ‘mesenchymal stromal cells’, ‘mesenchymal stem cell transplantation’, ‘inflammatory bowel diseases’, ‘Crohn disease’ and ‘colitis, ulcerative’. Additional publications were identified from individual article reference lists. Results MSCs include inhibition of Th1/Th17 lymphocytes and recruitment of regulatory T lymphocytes, induction of antigen-presenting cells into a regulatorylike profile, and stimulation of epithelial cell differentiation and proliferation. More than 200 patients with refractory fistulas have been treated with local injections of MSCs, resulting in complete response in more than half, and in overall response in approximately two thirds of patients. In refractory luminal Crohn’s disease, 49 cases of systemic MSC infusions have been reported, while trials with autologous MSCs resulted in mitigated responses, studies using allogeneic MSCs were promising, with around 60% of patients experiencing a response and around 40% achieving clinical remission. Conclusions Mesenchymal stromal cells might represent a promising therapy for IBD, especially for Crohn’s disease. There remain many unsolved questions concerning the optimal origin and source of mesenchymal stromal cells, dosage and modalities of administration. Moreover, mesenchymal stromal cells still need to prove their effectiveness compared with conventional treatments in randomised controlled trials. [less ▲]

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See detailUpgrading opportunities in agricultural value chains: Lessons from the analysis of the consumption of processed pineapple products in southern Benin
Aoudji, Augustin K.N.; Avocevou-Ayisso, Carole; Adégbidi, Anselme et al

in African Journal of Science, Technology, Innovation and Development (2017), 2017

This study analyzed the consumption of processed pineapple products in southern Benin. The low processing of agricultural products does not enable sub-Saharan Africa to exploit the potential of ... [more ▼]

This study analyzed the consumption of processed pineapple products in southern Benin. The low processing of agricultural products does not enable sub-Saharan Africa to exploit the potential of agriculture for development. The objective of this paper was to identify upgrading opportunities in Benin’s pineapple value chain. A survey was carried out from December 2012 to February 2013 among 250 respondents randomly selected in five cities in southern Benin; and data were collected based on structured interviews. Dried pineapple, jam, syrup, juice, and cocktail were the processed pineapple products available on the market. Beverages, especially the juice, were the main processed pineapple products. The motivations driving the purchase of processed pineapple beverages by consumers were: competitive price and interest in local, natural and therapeutic beverages. The results indicate there is a margin for the value chain to upgrade products and services, and increase the price of pineapple-based products while staying competitive. A strong marketing and advertisement campaign is essential to support wider knowledge of processed pineapple products by consumers. Product traceability is a prerequisite for export in regional and international markets. This makes the certification of the value chain a critical issue. A joint action of value chain stakeholders is needed to exploit these opportunities. [less ▲]

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See detailA dynamic, sex-specific expression pattern of genes regulating thyroid hormone action in the developing zebra finch song control system
Raymaekers, S.R.; Verbeure, W.; Ter Haar, S.M. et al

in General and Comparative Endocrinology (2017), 240

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel ... [more ▼]

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel- lent model to study developmental neuroplasticity. Despite the demonstrated influence of hormones such as sex steroids on this phenomenon, thyroid hormones (THs) – an important factor in neural devel- opment and maturation – have not been studied in this regard. We used in situ hybridization to compare the expression of TH transporters, deiodinases and receptors between both sexes during all phases of song development in male zebra finch. Comparisons were made in four song control nuclei: Area X, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), HVC (used as proper name) and the robust nucleus of the arcopallium (RA). Most genes regulating TH action are expressed in these four nuclei at early stages of development. However, while general expression levels decrease with age, the activating enzyme deiodinase type 2 remains highly expressed in Area X, HVC and RA in males, but not in females, until 90days post-hatch (dph), which marks the end of sensorimotor learning. Furthermore, the L-type amino acid transporter 1 and TH receptor beta show elevated expression in male HVC and RA respectively compared to surrounding tissue until adulthood. Differences compared to sur- rounding tissue and between sexes for the other TH regulators were minor. These developmental changes are accompanied by a strong local increase in vascularization in the male RA between 20 and 30 dph but not in Area X or HVC. Our results suggest that local regulation of TH signaling is an important factor in the development of the song control nuclei during the song learning phase and that TH activation by DIO2 is a key player in this process. [less ▲]

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See detailHigh-resolution regional modelling of natural and anthropogenic radiocarbon in the Mediterranean Sea
Ayache, M.; Dutay, J.-C.; Mouchet, Anne ULiege et al

in Biogeosciences (2017), 14(5), 1197-1213

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See detailObjective assessment of visual pursuit in patients with disorders of consciousness: an exploratory study.
Wannez, Sarah ULiege; Hoyoux, Thomas; Langohr, Thomas et al

in Journal of Neurology (2017)

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See detailTracking Invasive Alien Species (TrIAS): Building a data-driven framework to inform policy
Vanderhoeven, Sonia; Adriaens, Tim; Desmet, Peter et al

in Research Ideas and Outcomes (2017), 3

Imagine a future where dynamically, from year to year, we can track the progression of alien species (AS), identify emerging problem species, assess their current and future risk and timely inform policy ... [more ▼]

Imagine a future where dynamically, from year to year, we can track the progression of alien species (AS), identify emerging problem species, assess their current and future risk and timely inform policy in a seamless data-driven workflow. One that is built on open science and open data infrastructures. By using international biodiversity standards and facilities, we would ensure interoperability, repeatability and sustainability. This would make the process adaptable to future requirements in an evolving AS policy landscape both locally and internationally. In recent years, Belgium has developed decision support tools to inform invasive alien species (IAS) policy, including information systems, early warning initiatives and risk assessment protocols. However, the current workflows from biodiversity observations to IAS science and policy are slow, not easily repeatable, and their scope is often taxonomically, spatially and temporally limited. This is mainly caused by the diversity of actors involved and the closed, fragmented nature of the sources of these biodiversity data, which leads to considerable knowledge gaps for IAS research and policy. We will leverage expertise and knowledge from nine former and current BELSPO projects and initiatives: Alien Alert, Invaxen, Diars, INPLANBEL, Alien Impact, Ensis, CORDEX.be, Speedy and the Belgian Biodiversity Platform. The project will be built on two components: 1) The establishment of a data mobilization framework for AS data from diverse data sources and 2) the development of data-driven procedures for risk evaluation based on risk modelling, risk mapping and risk assessment. We will use facilities from the Global Biodiversity Information Facility (GBIF), standards from the Biodiversity Information Standards organization (TDWG) and expertise from Lifewatch to create and facilitate a systematic workflow. Alien species data will be gathered from a large set of regional, national and international initiatives, including citizen science with a wide taxonomic scope from marine, terrestrial and freshwater environments. Observation data will be funnelled in repeatable ways to GBIF. In parallel, a Belgian checklist of AS will be established, benefiting from various taxonomic and project-based checklists foreseen for GBIF publication. The combination of the observation data and the checklist will feed indicators for the identification of emerging species; their level of invasion in Belgium; changes in their invasion status and the identification of areas and species of concern that could be impacted upon by bioinvasions. Data-driven risk evaluation of identified emerging species will be supported by niche and climate modelling and consequent risk mapping using critical climatic variables for the current and projected future climate periods at high resolution. The resulting risk maps will complement risk assessments performed with the recently developed Harmonia+ protocol to assess risks posed by emergent species to biodiversity and human, plant, and animal health. The use of open data will ensure that interested stakeholders in Belgium and abroad can make use of the information we generate. The open science ensures everyone is free to adopt and adapt the workflow for different scenarios and regions. The checklist will be used at national level, but will also serve as the Belgian reference for international databases (IUCN - GRIIS, EASIN) and impact assessments (IPBES, SEBI). The workflow will be showcased through GEO BON, the Invasivesnet network and the COST Actions Alien Challenge and ParrotNet. The observations and outcomes of risk evaluations will be used to provide science-based support for the implementation of IAS policies at the regional, federal and EU levels. The publication of Belgian data and checklists on IAS is particularly timely in light of the currently ongoing EU IAS Regulation and its implementation in Belgium. By proving that automated workflows can provide rapid and repeatable production of information, we will open up this technology for other conservation assessments. [less ▲]

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See detailThe clinical relevance of imatinib plasma trough concentrations in chronic myeloid leukemia. A Belgian study
Van Obbergh, F; Knoops, L; Devos, T et al

in Clinical Biochemistry (2017), 50

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice ... [more ▼]

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice. Forty-one patients, with 47 imatinib plasma measurements, were analyzed during treatment with imatinib given at a fixed 400mg daily dose. A significant inverse relationship of imatinib concentration with the patients' weight was observed (Pearson's test: p=0.02,R2=0.1). More interestingly, patientswith poor response (switched to another tyrosine kinase inhibitor because of imatinib failure, or because of disease progression after an initial response) displayed a significantly lower mean imatinib concentration as compared to patients maintained on imatinib (822 ng/mL vs 1099 ng/mL; Student's t-test, p=0.04). Failure or disease progression occurred more often in patients in the lowest quartile of imatinib concentrations compared to patients in the highest quartile (p = 0.02, logrank test). No correlation could be established with other biological or clinical parameter, including complete cytogenic response and majormolecular response. In conclusion: in patients treatedwith imatinib at a fixed daily dose of 400 mg, imatinib plasma concentrations decreased with increasing body weight and were lower in patients switched to another tyrosine kinase inhibitor due to imatinib failure. Systematic determination of imatinib plasma trough levels should be encouraged in such patients. [less ▲]

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See detailIntermodal network design: a three-mode bi-objective model applied to the case of Belgium
Mostert, Martine ULiege; Caris, An; Limbourg, Sabine ULiege

in Flexible Services and Manufacturing Journal (2017)

Freight transport planning is nowadays encouraged to align with environmental objectives. Among those, climate change is of particular interest for many countries. In its White Paper on Transport, the ... [more ▼]

Freight transport planning is nowadays encouraged to align with environmental objectives. Among those, climate change is of particular interest for many countries. In its White Paper on Transport, the European Commission considers intermodal transport as a potential solution for reducing environmental impacts. In order to make good strategic transport decisions, realistic decision support models for freight transport networks must be developed, so that insights can be derived for the different stakeholders of the transportation chain. This research proposes a bi-objective mathematical formulation which takes into account economic and environmental objectives, on a road and intermodal network with three modes of transport (road, intermodal rail, and intermodal inland waterways), and in which economies of scale of intermodal transport can be considered. With this model better fitting reality, an application to the Belgian case study provides practical information on how flows, terminal types and locations vary depending on the chosen policy, on the integration or not of economies of scale, on costs or emissions modifications and on the number of terminals to locate. Results show that the chosen policy influences the terminal type and the intermodal market share. The study also highlights the interest of intermodal transport on short distances, and the risk of flow exchanges inside the intermodal market share, rather than between road and intermodal transport. [less ▲]

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See detailMiddle Ordovician acritarchs and problematic organic-walled microfossils from the Saq-Hanadir transitional beds in the QSIM-801 well, Saudi Arabia
Le Hérissé, A.; Guidat, C.; Not, F. et al

in Revue de Micropaléontologie (2017), 60

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See detailLooking beyond general metrics for model comparison – lessons from an international model intercomparison study
de Boer-Euser, Tanja; Bouaziz, Laurène; De Niel, Jan et al

in Hydrology and Earth System Sciences (2017), 21

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for ... [more ▼]

International collaboration between research institutes and universities is a promising way to reach consensus on hydrological model development. Although comparative studies are very valuable for international cooperation, they do often not lead to very clear new insights regarding the relevance of the modelled processes. We hypothesise that this is partly caused by model complexity and the comparison methods used, which focus too much on a good overall performance instead of focusing on specific events. In this study, we use an approach that focuses on the evaluation of specific events and characteristics. Eight international research groups calibrated their hourly model on the Ourthe catchment in Belgium and carried out a validation in time for the Ourthe catchment and a validation in space for nested and neighbouring catchments. The same protocol was followed for each model and an ensemble of best performing parameter sets was selected. Although the models showed similar performances based on general metrics (i.e. Nash–Sutcliffe Efficiency), clear differences could be observed for specific events. The results illustrate the relevance of including a very quick flow reservoir preceding the root zone storage to model peaks during low flows and including a slow reservoir in parallel with the fast reservoir to model the recession for the Ourthe catchment. This intercomparison enhanced the understanding of the hydrological functioning of the catchment and, above all, helped to evaluate each model against a set of alternative models. [less ▲]

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See detailSedation of Patients With Disorders of Consciousness During Neuroimaging: Effects on Resting State Functional Brain Connectivity.
KIRSCH, Murielle ULiege; Guldenmund, Pieter; Bahri, Mohamed Ali ULiege et al

in Anesthesia and Analgesia (2017), 124(2),

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See detailPersistence of the effec of frugivore identity on post-dispersal seed fate: consequences for the assessment of functional redundancy
Lugon, Ana Paula; Boutefeu, Marion; Bovy, Emilie et al

in Biotropica (2017)

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See detailNew directions in hypnosis research: strategies for advancing the cognitive and clinical neuroscience of hypnosis
Jensen, Mark P; Jamieson, Graham A; Lutz, Antoine et al

in Neuroscience of Consciousness (2017), 3(1), 1-14

In August of 2015, the International Society of Hypnosis and Confederation Francophone d’hypnose et Therapies Breves co-sponsored a 1-day meeting among hypnosis researchers, just before the International ... [more ▼]

In August of 2015, the International Society of Hypnosis and Confederation Francophone d’hypnose et Therapies Breves co-sponsored a 1-day meeting among hypnosis researchers, just before the International Congress of Hypnosis in Paris, France. One of the goals of the meeting was to discuss the state-of-the- science of hypnosis research from the purview of clinical and cognitive neuroscience. The purpose of this article is to summarize the key issues that were raised during the discussions, including the points of agreement and disagreement among the participants (all of whom are authors on this article). Here we first briefly summarize what we view as (i) the most important research findings and developments in the field during the past two decades and (ii) the most salient challenges facing contemporary hypnosis research. Next, we summarize our discussion concerning directions for future hypnosis research and collaborative endeavors that could expand upon recent advances, ad- dress emerging challenges, and facilitate a reemergence of hypnosis research as a vital field within cognitive and clinical neuroscience. [less ▲]

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See detailReduced intensity and non-myeloablative allogenic stem cell transplantation from alternative HLA-mismatched donors for Hodgkin's lymphoma: a study by the French Society of Bone Marrow Transplantation and Cellular Therapy
Gauthier, J; Castagna, L; Garnier, F et al

in Bone Marrow Transplantation (2017), 52

Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed ... [more ▼]

Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed Hodgkin lymphoma (HL). When an HLA-matched donor is lacking a graft from a familial haploidentical (HAPLO) donor, a mismatched unrelated donor (MMUD) or cord blood (CB) might be considered. In this retrospective study, we compared the outcome of patients with HL undergoing a RIC or NMA allo-SCT from HAPLO, MMUD or CB. Ninety-eight patients were included. Median follow-up was 31 months for the whole cohort. All patients in the HAPLO group (N = 34) received a T-cell replete allo-SCT after a NMA (FLU-CY-TBI, N = 31, 91%) or a RIC (N = 3, 9%) followed by post-transplant cyclophosphamide. After adjustment for significant covariates, MMUD and CB were associated with significantly lower GvHD-free relapse-free survival (GRFS; hazard ratio (HR) = 2.02, P = 0.03 and HR = 2.43, P = 0.009, respectively) compared with HAPLO donors. In conclusion, higher GRFS was observed in Hodgkin lymphoma patients receiving a RIC or NMA allo-SCT with posttransplant cyclophosphamide from HAPLO donors. Our findings suggest they should be favoured over MMUD and CB in this setting. [less ▲]

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See detailImpact of pollen resources drift on common bumblebees in NW Europe
Roger, N.; Moerman, R.; Carvalheiro, L. G. et al

in Global Change Biology (2017), 23(1), 68-76

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant ... [more ▼]

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant abundance and quality. Here, we investigate whether generalist bumblebee species, with stable population trends over the past years, adapted their diets in response to changes in the distribution and chemical quality of their pollen resources. We selected five common species of bumblebee in NW Europe for which we had a precise description of their pollen diet through two time periods (‘prior to 1950’ and ‘2004–2005’). For each species, we assessed whether the shift in their pollen diet was related with the changes in the suitable area of their pollen resources. Concurrently, we evaluated whether the chemical composition of pollen resources changed over time and experimentally tested the impact of new major pollen species on the development of B. terrestris microcolonies. Only one species (i.e. B. lapidarius) significantly included more pollen from resources whose suitable area expanded. This opportunist pattern could partly explain the expansion of B. lapidarius in Europe. Regarding the temporal variation in the chemical composition of the pollen diet, total and essential amino acid contents did not differ significantly between the two time periods while we found significant differences among plant species. This result is driven by the great diversity of resources used by bumblebee species in both periods. Our bioassay revealed that the shift to new major pollen resources allowed microcolonies to develop, bringing new evidence on the opportunist feature of bumblebee in their diets. Overall, this study shows that the response to pollen resource drift varies among closely related pollinators, and a species-rich plant community ensures generalist species to select a nutrient-rich pollen diet. © 2016 John Wiley & Sons Ltd [less ▲]

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See detailGenomewide association of piglet responses to infection with one of two porcine reproductive and respiratory syndrome virus isolates.
Waide, E. H.; Tuggle, C. K.; Serao, N. V. L. et al

in Journal of Animal Science (2017), 95(1), 16-38

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease in the swine industry. Identification of host genetic factors that enable selection for improved performance during PRRS virus ... [more ▼]

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease in the swine industry. Identification of host genetic factors that enable selection for improved performance during PRRS virus (PRRSV) infection would reduce the impact of this disease on animal welfare and production efficiency. We conducted genomewide association study (GWAS) analyses of data from 13 trials of approximately 200 commercial crossbred nursery-age piglets that were experimentally infected with 1 of 2 type 2 isolates of PRRSV (NVSL 97-7985 [NVSL] and KS2006-72109 [KS06]). Phenotypes analyzed were viral load (VL) in blood during the first 21 d after infection (dpi) and weight gain (WG) from 0 to 42 dpi. We accounted for the previously identified QTL in the region on SSC4 in our models to increase power to identify additional regions. Many regions identified by single-SNP analyses were not identified using Bayes-B, but both analyses identified the same regions on SSC3 and SSC5 to be associated with VL in the KS06 trials and on SSC6 in the NVSL trials ( < 5 x 10); for WG, regions on SSC5 and SSC17 were associated in the NVSL trials ( < 3 x 10). No regions were identified with either method for WG in the KS06 trials. Except for the region on SSC4, which was associated with VL for both isolates (but only with WG for NVSL), identified regions did not overlap between the 2 PRRSV isolate data sets, despite high estimates of the genetic correlation between isolates for traits based on these data. We also identified genomic regions whose associations with VL or WG interacted with either PRRSV isolate or with genotype at the SSC4 QTL. Gene ontology (GO) annotation terms for genes located near moderately associated SNP ( < 0.003) were enriched for multiple immunologically (VL) and metabolism- (WG) related GO terms. The biological relevance of these regions suggests that, although it may increase the number of false positives, the use of single-SNP analyses and a relaxed threshold also increased the identification of true positives. In conclusion, although only the SSC4 QTL was associated with response to both PRRSV isolates, genes near associated SNP were enriched for the same GO terms across PRRSV isolates, suggesting that host responses to these 2 isolates are affected by the actions of many genes that function together in similar biological processes. [less ▲]

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See detailSpecial issue on Caryl Phillips
Ledent, Bénédicte ULiege

in Ariel : A Review of International English Literature (2017), 48(3&4), 1-247

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See detailFluvial archives, a valuable record of vertical crustal deformation
Demoulin, Alain ULiege; Mather, Anne; Whittaker, Alexander

in Quaternary Science Reviews (2017)

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature ... [more ▼]

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature of crustal deformation and its history. In recent decades, geomorphic analysis of rivers has proved powerful in elucidating the tectonic evolution of actively uplifting and eroding orogens. Here, we review the main recent developments that have improved and expanded qualitative and quantitative information about vertical tectonic motions (the effects of horizontal deformation are not addressed). Channel long profiles have received considerable attention in the literature, and we briefly introduce basic aspects of the behaviour of bedrock rivers from field and numerical modelling perspectives, before describing the various metrics that have been proposed to identify the information on crustal deformation contained within their steady-state characteristics. Then, we review the literature dealing with the transient response of rivers to tectonic perturbation, through the production of knickpoints propagating through the drainage network. Inverse modelling of river profiles for uplift in time and space is also shown to be very effective in reconstructing regional tectonic histories. Finally, we present a synthetic morphometric approach for deducing the tectonic record of fluvial landscapes. As well as the erosional imprint of tectonic forcing, sedimentary deposits, such as fluvial terrace staircases, are also considered as a classical component of tectonic geomorphology. We show that these studies have recently benefited from rapid advances in dating techniques, allowing more reliable reconstruction of incision histories and estimation of incision rates. The combination of progress in the understanding of transient river profiles and larger, more rigorous data sets of terrace ages has led to improved understanding of river erosion and the implications for terrace profile correlation, i.e., extrapolation of local data to entire profiles. Finally, planform changes in fluvial systems are considered at the channel scale in alluvial rivers and regional level in terms of drainage reorganisation. Examples are given of how numerical modelling can efficiently combine with topographic data to shed new light on the (dis)equilibrium state of drainage systems across regional drainage divides. [less ▲]

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See detailTime related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.
Klaassens, Bernadet L.; Rombouts, Serge A. R. B.; Winkler, Anderson ULiege et al

in Human Brain Mapping (2017), 38(1), 308-325

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the ... [more ▼]

Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired per subject during this randomized, double blind, placebo-controlled, crossover study. Within-group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P < 0.05, FWE-corrected) using a non-parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self-referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects. Hum Brain Mapp 38:308-325, 2017. (c) 2016 Wiley Periodicals, Inc. [less ▲]

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See detailTargeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases.
Garcia-Caballero, Melissa; Paupert, Jenny; Blacher, Silvia ULiege et al

in Journal of Hematology & Oncology (2017), 10(1), 122

BACKGROUND: Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic ... [more ▼]

BACKGROUND: Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic vessels (lymphangiogenesis) in primary tumors facilitates tumor cell dissemination to regional lymph nodes and correlates with distant metastases. Lymphangiogenesis has thus emerged as a suitable therapeutic target to block metastases, but no anti-lymphangiogenic compounds have been approved for clinical use to date. Therefore, new or improved therapies blocking lymphatic metastases are urgently required. METHODS: We established murine breast tumors to assess the effect of AD0157 on tumor growth, lymphangiogenesis, and lymphatic dissemination. Then, a battery of in vivo (mouse corneal neovascularization and ear sponges), ex vivo (mouse lymphatic rings and rat mesentery explants), and in vitro (proliferation, tubulogenesis, wound-healing, Boyden chambers, and spheroids) assays was used to give insight into the lymphangiogenic steps affected by AD0157. Finally, we investigated the molecular pathways controlled by this drug. RESULTS: AD0157 was found to inhibit the growth of human breast cancer xenografts in mice, to strongly reduce tumor-associated lymphangiogenesis and to block metastatic dissemination to both lymph nodes and distant organs. The high anti-lymphangiogenic potency of AD0157 was further supported by its inhibitory activity at low micromolar range in two in vivo pathological models and in two ex vivo assays. In addition, AD0157 inhibited lymphatic endothelial cell proliferation, migration and invasion, cellular sprouting, and tube formation. Mechanistically, this compound induced apoptosis in lymphatic endothelial cells and decreased VEGFR-3/-2, ERK1/2, and Akt phosphorylations. CONCLUSIONS: These findings demonstrate the suitability of AD0157 to suppress tumor-associated lymphangiogenesis. Beyond discovering a new potent anti-lymphangiogenic drug that is worth considering in future clinical settings, our study supports the interest of designing anti-lymphangiogenic therapies to avoid distant metastatic processes. [less ▲]

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See detailMultiple Gas-Phase Conformations of a Synthetic Linear Poly(acrylamide) Polymer Observed Using Ion Mobility-Mass Spectrometry
Haler, Jean ULiege; Far, Johann ULiege; Aqil, Abdelhafid ULiege et al

in Journal of the American Society for Mass Spectrometry (2017), 28(11), 24922499

Ion mobility-mass spectrometry (IM-MS) has emerged as a powerful separation and identification tool to characterize synthetic polymer mixtures and topologies (linear, cyclic, star-shaped ... [more ▼]

Ion mobility-mass spectrometry (IM-MS) has emerged as a powerful separation and identification tool to characterize synthetic polymer mixtures and topologies (linear, cyclic, star-shaped,...). Electrospray coupled to IM-MS already revealed the coexistence of several charge state-dependent conformations for a single charge state of biomolecules with strong intramolecular interactions, even when limited resolving power IM-MS instruments were used. For synthetic polymers, the sample's polydispersity allows the observation of several chain lengths. A unique collision cross-section (CCS) trend is usually observed when increasing the degree of polymerization (DP) at constant charge state, allowing the deciphering of different polymer topologies. In this paper, we report multiple coexisting CCS trends when increasing the DP at constant charge state for linear poly(acrylamide) PAAm in the gas phase. This is similar to observations on peptides and proteins. Biomolecules show in addition population changes when collisionally heating the ions. In the case of synthetic PAAm, fragmentation occurred before reaching the energy for conformation conversion. These observations, which were made on two different IM-MS instruments (SYNAPT G2 HDMS and high resolution multi-pass cyclic T-Wave prototype from Waters), limit the use of ion mobility for synthetic polymer topology interpretations to polymers where unique CCS values are observed for each DP at constant charge state. [less ▲]

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See detailPostoperative care in endoscopic sinus surgery: a critical review.
Eloy, Philippe; Andrews, Peter; POIRRIER, Anne-Lise ULiege

in Current Opinion in Otolaryngology & Head & Neck Surgery (2017), 25(1), 35-42

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard ... [more ▼]

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard treatment for medically refractive disease. Postoperative care is recommended by international leaders as an important part of the patient's management. This article is a critical review and discussion focusing on postoperative care, which is based on expert opinion, clinical studies, randomized controlled trials and meta-analysis studies. RECENT FINDINGS: Postoperative care including nasal rinsing, topical corticosteroids, antibiotics and avoidance of nasal packing are unanimously considered to be the cornerstone of best practice following FESS. However, the effectiveness of in-office nasal debridement is still under debate. SUMMARY: There is a lack of consensus regarding the necessity of performing in-office nasal debridement and the majority of clinicians carry out their postoperative care according to experience and their own preference. This is often determined by the extent of surgery performed, the severity of the postoperative inflammation, as well as being dependent on the patient's discomfort, the time constraints associated with postoperative care and the costs associated with additional appointments. Ideally, nasal debridement should be performed by the operating surgeon under endoscopic control both gently and atraumatically. [less ▲]

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See detailUnderstanding and overcoming metformin gastrointestinal intolerance.
Bonnet, Fabrice; Scheen, André ULiege

in Diabetes, Obesity & Metabolism (2017), 19(473-481),

Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacologic option as supported by multiple international guidelines, yet a rather large ... [more ▼]

Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacologic option as supported by multiple international guidelines, yet a rather large proportion of patients cannot tolerate metformin in adequate amounts because of its associated gastrointestinal (GI) adverse events (AEs). GI AEs typically encountered with metformin therapy include diarrhoea, nausea, flatulence, indigestion, vomiting, and abdominal discomfort, with diarrhoea and nausea being the most common. Although starting at a low dose and titrating slowly may help prevent some of metformin's GI AEs, some patients are unable to tolerate metformin at all and it may also be difficult to convince patients to start metformin again after a bout of GI AEs. Despite this clinical importance the underlying mechanisms of metformin's GI intolerance are poorly known. This review discusses the epidemiology of metformin GI intolerance; its underlying mechanisms; genotype variability and associated factors affecting metformin GI intolerance, such as comorbidities, co-medications, and bariatric surgery; clinical consequences, and therapeutic strategies to overcome metformin GI intolerance. These strategies include appropriate titration of immediate-release metformin, use of extended-release metformin, the promise of delayed-release metformin and gut microbiome modulators, and alternative pharmacological therapies when metformin cannot be tolerated at all. Given the available data, all efforts should be made to maintain metformin before considering a shift to another drug therapy. [less ▲]

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See detailInvited review: Phenotypes to genetically reduce greenhouse gas emissions in dairying
de Haas, Yvette; Pszczola, Marcin; Soyeurt, Hélène ULiege et al

in Journal of Dairy Science (2017), 100(2), 855-870

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See detailInvestigating resting-state functional connectivity in the cervical spinal cord at 3T.
Eippert, Falk; Kong, Yazhuo; Winkler, Anderson ULiege et al

in NeuroImage (2017), 147

The study of spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signal has recently been extended from the brain to the spinal cord. Two ultra-high field functional magnetic resonance ... [more ▼]

The study of spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signal has recently been extended from the brain to the spinal cord. Two ultra-high field functional magnetic resonance imaging (fMRI) studies in humans have provided evidence for reproducible resting-state connectivity between the dorsal horns as well as between the ventral horns, and a study in non-human primates has shown that these resting-state signals are impacted by spinal cord injury. As these studies were carried out at ultra-high field strengths using region-of-interest (ROI) based analyses, we investigated whether such resting-state signals could also be observed at the clinically more prevalent field strength of 3T. In a reanalysis of a sample of 20 healthy human participants who underwent a resting-state fMRI acquisition of the cervical spinal cord, we were able to observe significant dorsal horn connectivity as well as ventral horn connectivity, but no consistent effects for connectivity between dorsal and ventral horns, thus replicating the human 7T results. These effects were not only observable when averaging along the acquired length of the spinal cord, but also when we examined each of the acquired spinal segments separately, which showed similar patterns of connectivity. Finally, we investigated the robustness of these resting-state signals against variations in the analysis pipeline by varying the type of ROI creation, temporal filtering, nuisance regression and connectivity metric. We observed that - apart from the effects of band-pass filtering - ventral horn connectivity showed excellent robustness, whereas dorsal horn connectivity showed moderate robustness. Together, our results provide evidence that spinal cord resting-state connectivity is a robust and spatially consistent phenomenon that could be a valuable tool for investigating the effects of pathology, disease progression, and treatment response in neurological conditions with a spinal component, such as spinal cord injury. [less ▲]

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See detailINPP5E Preserves Genomic Stability through Regulation of Mitosis
Sierra Potchanant, EA; Cerabona, D; Sater, ZA et al

in Molecular and Cellular Biology (2017), 37(6), 500-516

The partially understood phosphoinositide signaling cascade regulates multiple aspects of cellular metabolism. Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is ... [more ▼]

The partially understood phosphoinositide signaling cascade regulates multiple aspects of cellular metabolism. Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in the developmental disorders Joubert and MORM syndromes, is essential for the function of the primary cilium and maintenance of phosphoinositide balance in nondividing cells. Here, we report that INPP5E further contributes to cellular homeostasis by regulating cell division. We found that silencing or genetic knockout of INPP5E in human and murine cells impairs the spindle assembly checkpoint, centrosome and spindle function, and maintenance of chromosomal integrity. Consistent with a cell cycle regulatory role, we found that INPP5E expression is cell cycle dependent, peaking at mitotic entry. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit. Our findings identify the previously unknown, essential role of INPP5E in mitosis and prevention of aneuploidy, providing a new perspective on the function of this phosphoinositide phosphatase in health and development. [less ▲]

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See detailManagement of abdominal wall desmoid tumors.
DETRY, Olivier ULiege

in Acta Chirurgica Belgica (2017)

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See detailComparison of clinical effects of epidural levobupivacaine morphine versus bupivacaine morphine in dogs undergoing elective pelvic limb surgery
Cerasoli, Ilaria; Tutunaru, Alexandru-Cosmin ULiege; Cenani, Alessia et al

in Veterinary Anaesthesia & Analgesia (2017)

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