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 References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 1001 to 1100 of 55847     6 7 8 9 10 11 12 13 14 15 16     Cultural Practices Shaping Zoonotic Diseases Surveillance: The Case of Highly Pathogenic Avian Influenza and Thailand Native Chicken Farmers.Delabouglise, Alexis; Antoine-Moussiaux, Nicolas ; Tatong, D. et alin Transboundary and Emerging Diseases (2016)Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population. Eval- uating the acceptability of passive ... [more ▼]Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population. Eval- uating the acceptability of passive surveillance and its economic, social and cul- tural determinants appears a critical step for improving it. A participatory rural appraisal was implemented in a rural subdistrict of Thailand. Focus group inter- views were used to identify sanitary risks perceived by native chicken farmers and describe the structure of their value chain. Qualitative individual interviews with a large diversity of actors enabled to identify perceived costs and benefits associ- ated with the reporting of HPAI suspicions to sanitary authorities. Besides, flows of information on HPAI suspected cases were assessed using network analysis, based on data collected through individual questionnaires. Results show that the presence of cockfighting activities in the area negatively affected the willingness of all chicken farmers and other actors to report suspected HPAI cases. The high financial and affective value of fighting cocks contradicted the HPAI control pol- icy based on mass culling. However, the importance of product quality in the native chicken meat value chain and the free veterinary services and products delivered by veterinary officers had a positive impact on suspected case reporting. Besides, cockfighting practitioners had a significantly higher centrality than other actors in the information network and they facilitated the spatial diffusion of information. Social ties built in cockfighting activities and the shared purpose of protecting valuable cocks were at the basis of the diffusion of information and the informal collective management of diseases. Building bridges with this informal network would greatly improve the effectiveness of passive surveillance. [less ▲]Detailed reference viewed: 19 (4 ULg) Assessment of cardiovascular risk of new drugs for the treatment of diabetes mellitus: risk assessment vs. risk aversion.Zannad, Faiez; Stough, Wendy Gattis; Lipicky, Raymond J. et alin European heart journal. Cardiovascular pharmacotherapy (2016), 2(3), 200-205The Food and Drug Administration issued guidance for evaluating the cardiovascular risk of new diabetes mellitus drugs in 2008. Accumulating evidence from several completed trials conducted within this ... [more ▼]The Food and Drug Administration issued guidance for evaluating the cardiovascular risk of new diabetes mellitus drugs in 2008. Accumulating evidence from several completed trials conducted within this framework raises questions as to whether requiring safety outcome studies for all new diabetes mellitus therapies remains justified. Given the burden of cardiovascular disease in patients with diabetes, the focus should shift towards cardiovascular outcome studies designed to evaluate efficacy (i.e. to determine the efficacy of a drug over placebo or standard care) rather than demonstrating that risk is not increased by a pre-specified safety margin. All stakeholders are responsible for ensuring that new drug approvals occur under conditions of appropriate safety and effectiveness. It is also a shared responsibility to avoid unnecessary hurdles that may compromise access to useful drugs and threaten the sustainability of health systems. It is critical to renew this debate so that stakeholders can collectively determine the optimal approach for developing new drugs to treat type 2 diabetes mellitus. [less ▲]Detailed reference viewed: 5 (0 ULg) Contribution à l’écologie des coléoptères coprophiles et coprophages en Belgique : diversité spécifique, préférences stercorales et phénologieBebermans, Julien ; Fagot, Jean ; Francis, Frédéric in Entomologie Faunistique = Faunistic Entomology (2016), 69In a study performed from September to October 2014, coprophagous and coprophilic beetle of cattle and horse dung were observed. This research focused on Scarabaeoidea super-family and Staphylinidae ... [more ▼]In a study performed from September to October 2014, coprophagous and coprophilic beetle of cattle and horse dung were observed. This research focused on Scarabaeoidea super-family and Staphylinidae family. Totally, 6245 individuals, belonging to 15 coprophagous scarabs species and 73 staphylinids species were identified. Insects have been captured using a trap weekly visited. Three geographic regions were compared: Pays de Herve, Hesbaye and Pays Brabançon with one trapping site by region, respectively Julémont, Waremme and Grez-Doiceau. One of the objectives was to observe the insects population diversity according to dung type and identify insect preference related to a specific type of dung. The goal was to observe if the communities change between regions. The population dynamics during the ageing of dung has also been considered. Several species showed a significant preference for one of the two kind of feces, even if there are no strict specialist insects. Also, Julémont appeared as being the most diversified site regarding staphylinds, while Grez-Doiceau seemed to be the most suitable place concerning scarabs. Finally, insects were found to invade very quickly the freshly dropped dung, while they seem less attracted after a few days. [less ▲]Detailed reference viewed: 12 (2 ULg) The Perceived Value of Passive Animal Health Surveillance: The Case of Highly Pathogenic Avian Influenza in VietnamDelabouglise, Alexis; Antoine-Moussiaux, Nicolas ; Phan, T.D et alin Zoonoses and Public Health (2016), 63(2), 112-28Economic evaluations are critical for the assessment of the efficiency and sustain- ability of animal health surveillance systems and the improvement of their effi- ciency. Methods identifying and ... [more ▼]Economic evaluations are critical for the assessment of the efficiency and sustain- ability of animal health surveillance systems and the improvement of their effi- ciency. Methods identifying and quantifying costs and benefits incurred by public and private actors of passive surveillance systems (i.e. actors of veterinary author- ities and private actors who may report clinical signs) are needed. This study pre- sents the evaluation of perceived costs and benefits of highly pathogenic avian influenza (HPAI) passive surveillance in Vietnam. Surveys based on participatory epidemiology methods were conducted in three provinces in Vietnam to collect data on costs and benefits resulting from the reporting of HPAI suspicions to vet- erinary authorities. A quantitative tool based on stated preference methods and participatory techniques was developed and applied to assess the non-monetary costs and benefits. The study showed that poultry farmers are facing several options regarding the management of HPAI suspicions, besides reporting the fol- lowing: treatment, sale or destruction of animals. The option of reporting was associated with uncertain outcome and transaction costs. Besides, actors antici- pated the release of health information to cause a drop of markets prices. This cost was relevant at all levels, including farmers, veterinary authorities and private actors of the upstream sector (feed, chicks and medicine supply). One benefit associated with passive surveillance was the intervention of public services to clean farms and the environment to limit the disease spread. Private actors of the poultry sector valued information on HPAI suspicions (perceived as a non-mon- etary benefit) which was mainly obtained from other private actors and media. [less ▲]Detailed reference viewed: 78 (7 ULg) L’épandage d’engrais de ferme avant le semis d’une culture intermédiaire (CIPAN) présente-t-il un risque important de lixiviation de nitrate ?Vandenberghe, Christophe ; De Toffoli, Marc; Lambert, Richard et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(2), Description of the subject. The implementation of the Nitrates Directives in the Walloon region (in the south of Belgium) allows the summer spreading of any kind of manure on soils in preparation for the ... [more ▼]Description of the subject. The implementation of the Nitrates Directives in the Walloon region (in the south of Belgium) allows the summer spreading of any kind of manure on soils in preparation for the sowing of a catch crop. Objectives. This paper aims to assess whether the spreading of a manure before sowing a catch crop is more risky for groundwater quality than planting a cereal followed by another crop without any action being implemented between the harvesting of the cereal and the sowing (winter or spring) of the next crop. Method. This study is based on measurements of the nitrate nitrogen content of soils, at the beginning of the leaching period, performed on reference parcels and on controlled parcels. Results. Three thousand six hundred soil analyses performed in relation to controlled parcels between 2008 and 2013 showed that the presence of a catch crop (information about the possible application of a manure was not known) led to a nitrate nitrogen content (median) lower (with a very highly significant difference) than in a situation where no action was implemented between the two main crops. For the same period, the analysis of 600 results in reference parcels led to the same conclusion. Moreover, no significant difference was found between the two kinds of manure (“fast action”, such as pig slurry or “low action”, such as bovine manure). Conclusions. After the harvesting of a cereal, the spreading of a manure before sowing a catch crop creates no higher risk for water quality than the succession of a cereal by a crop sowed in the autumn. [less ▲]Detailed reference viewed: 32 (8 ULg) SPICAM observations and modeling of Mars auroraeSoret, Lauriane ; Gérard, Jean-Claude ; Libert, Ludivine et alin Icarus (2016), 264Martian aurorae have been detected with the SPICAM instrument on board Mars Express both in the nadir and the limb viewing modes. In this study, we focus on three limb observations to determine both the ... [more ▼]Martian aurorae have been detected with the SPICAM instrument on board Mars Express both in the nadir and the limb viewing modes. In this study, we focus on three limb observations to determine both the altitudes and the intensities of the auroral emissions. The CO (a3P–X1R) Cameron bands between 190 and 270 nm, the CO Fourth Positive system (CO 4P) between 135 and 170 nm, the CO2+ doublet at 289 nm, the OI at 297.2 nm and the 130.4 nm OI triplet emissions have been identified in the spectra and in the time variations of the signals. The intensities of these auroral emissions have been quantified and the altitude of the strongest emission of the CO Cameron bands has been estimated to be 137 ± 27 km. The locations of these auroral events have also been determined and correspond to the statistical boundary of open-closed magnetic field lines, in cusp-like structures. The observed altitudes of the auroral emissions are reproduced by a Monte-Carlo model of electron transport in the Martian thermosphere for mono-energetic electrons between 40 and 200 eV. No correlation between electron fluxes measured in the upper thermosphere and nadir auroral intensity has been found. Here, we simulate auroral emissions observed both at the limb and at the nadir using electron energy spectra simultaneously measured with the ASPERA-3/ELS instrument. The simulated altitudes are in very good agreement with the observations. We find that predicted vertically integrated intensities for the various auroral emissions are overestimated, probably as a consequence of the inclination and curvature of the magnetic field line threading the aurora. However, the relative brightness of the CO and CO2+ emissions is in good agreement with the observations. [less ▲]Detailed reference viewed: 47 (12 ULg) Structured carbons as supports for hydrogenation hybrid catalysts prepared by the immobilization of a Rh diamine complexGheorghiu, Cristina; Garcia-Bordeje, Enrique; Job, Nathalie et alin Chemical Engineering Journal (2016), 291Detailed reference viewed: 69 (10 ULg) Asymmetrical magnetic fabrics in the Egersund doleritic dike swarm (SW Norway) reveal sinistral oblique rifting before the opening of the IapetusMontalbano, Salvatrice ; Bolle, Olivier ; Diot, Hervéin Journal of Structural Geology (2016), 85Detailed reference viewed: 13 (1 ULg) Sludge dewatering and drying: about the difficulty of making experiments with a non-stabilized materialPambou, Yvon-Bert ; Fraikin, Laurent ; Salmon, Thierry et alin Desalination and Water Treatment (2016), 57(30), 13841-13856Detailed reference viewed: 73 (7 ULg) Pour une conception deleuzienne de l'interdiscursivitéFranck, Thomas in Alecsic.org (2016)Detailed reference viewed: 123 (85 ULg) High Temperature Ferromagnetism in a GdAg2 MonolayerOrmaza, M.; Fernandez, L.; Ilyn, M. et alin Nano Letters (2016), 0(0), Detailed reference viewed: 30 (2 ULg) Les gels de carbone: de la maîtrise de la texture à l'amélioration de procédésJob, Nathalie in Chimie Nouvelle (2016), 121Detailed reference viewed: 19 (1 ULg) The role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study.Runhaar, J.; DEROISY, Rita ; van Middelkoop, M. et alin Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 42-48Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a ... [more ▼]Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a tailored diet and exercise program (DEP)or by oral glucosamine sulfate in women at risk for the disease, using a composite clinical and/or radiological outcome. The aim of this updated post-hoc analysis was to re-assess the results according to more precise techniques and take advantage of the 2 x 2 factorial design. Methods: A total of 407 overweight( BMI > or egal 27kg/m2) women of 50–60 years of age with no diagnosis of knee OA were randomized to: (1) noDEP + placebo(Control, N = 102), (2) DEP + placebo (DEP, N = 101), (3) glucosamine sulfate + no DEP (GS, N = 102), and (4) DEP + glucosamine sulfate (DEP + GS, N = 102) and followed for 2.5 years, with standardized postero-anterior, semiflexed (MTP) view knee radiographs at baseline and end of the study. DEP consisted of a tailored low fat and/or low caloric diet and easy to implement physical activities. Glucosamine was given as oral crystalline glucosamine sulfate 1500 mg once daily ,double-blinded vs. placebo. Incident knee OA was defined as radiographic progression of >1mm minimum joint space narrowing (mJSN)in the medial tibiofemoral compartment, as previously assessed by the visual (manual) technique and by a new semi-automated method. Logistic regression analysis was used t ocalculate the odds ratio for the effect of the interventions. Results: After 2.5 years, 11.8% of control subjects developed knee OA. This incidence was decreased with glucosamine sulfate, either alone or in combination with the DEP, but not by the DEP alone. Since there was no statistical interaction between treatments, the 2x2 factorial design allowed analysis of patients receiving glucosamine sulfate (N = 204) vs. those not receiving it (N= 203), similarly for those on the DEP (N = 203) or not (N = 204). Glucosamine sulfate significantly decreased the risk of developing knee OA: odds ratio (OR) = 0.41(95% CI: 0.20–0.85, P = 0.02) by the manual JSN assessment method and OR = 0.42 (95% CI:0.20–0.92, P =0.03) by the semi-automated technique. Conversely, there was no decrease in risk with the DEP. Conclusions: Glucosamine sulfate decreased the risk of developing radiographic knee OA over 2.5 years in overweight, middle-aged women at risk, as determined by medial mJSN progression. Conversely a tailored diet and exercise program exerted no preventive effect, possibly because of the lower than expected effect on weigh tloss. [less ▲]Detailed reference viewed: 39 (7 ULg) Heterogeneous bedrock investigation for a closed-loop geothermal system: A case studyRadioti, Georgia ; Delvoie, Simon ; Charlier, Robert et alin Geothermics (2016)This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The ... [more ▼]This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The investigated site consists of four boreholes equipped with geothermal pipes on the campus of University of Liege, Belgium. The first approach includes acoustic borehole imaging, gamma-ray logging and cuttings observation and results to a detailed fracture characterisation, rock identification and layer dip angle determination. The second approach consists of measuring the thermal conductivity of cuttings at the laboratory. Study of cuttings thermal conductivity measurements can contribute to bedrock heterogeneity knowledge concerning the transition of one formation to another and the layer dipping. The third approach is based on high-resolution temperature profiles, measured during the hardening of the grouting material and the recovery phase of a Distributed Thermal Response Test. Through this approach a correlation of the temperature profiles to the geological characteristics of the surrounding bedrock is identified. The analysis of this correlation can provide information on fractured zones, alternation of different rock types and layering dipping. This latter approach can be easily applied on closed-loop geothermal systems to characterise the bedrock and investigate its heterogeneity as well as contribute to the their long-term behaviour prediction and to the optimisation of their efficiency. [less ▲]Detailed reference viewed: 47 (11 ULg) Fast Atmospheric Plasma Deposition of Bio-Inspired Catechol/Quinone-Rich Nanolayers to Immobilize NDM-1 Enzymes for Water TreatmentMauchauffé, Rodolphe; Bonot, Sébastien; Moreno-Couranjou, Maryline et alin Advanced Materials Interfaces (2016), 3(8), 101002Detailed reference viewed: 19 (2 ULg) What drives the development of community energy in Europe? The case of wind power cooperativesBauwens, Thomas ; Gotchev, Boris; Holstenkamp, Larsin Energy Research & Social Science (2016), 13The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being ... [more ▼]The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being paid to the transition process towards a more decentralized configuration. This article examines the factors likely to foster citizen and community participation as regards wind power cooperatives in Denmark, Germany, Belgium and the UK. Using Elinor Ostrom’s Social-Ecological System Framework, the analysis highlights a double-edged phenomenon: prevailing and growing hostility towards cooperatives, on the one hand, and, on the other, strategic reactions to this evolution. What comes out indeed is that, throughout most of these countries, the emergence of some coordinated inter-organizational actions among cooperatives enables them to survive in their critical environment. [less ▲]Detailed reference viewed: 203 (20 ULg) Insight into SUCNR1 (GPR91) structure and functionGilissen, Julie ; Jouret, François ; Pirotte, Bernard et alin Pharmacology & Therapeutics (2016)SUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR), which represents the largest group of membrane proteins in human genome. The majority of marketed drugs targets GPCRs ... [more ▼]SUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR), which represents the largest group of membrane proteins in human genome. The majority of marketed drugs targets GPCRs, directly or indirectly. SUCNR1 has been classified as an orphan receptor until a landmark study paired it with succinate, a citric acid cycle intermediate. According to the current paradigm, succinate triggers SUCNR1 signaling pathways to indicate local stress that may affect cellular metabolism. SUCNR1 implication has been well documented in renin-induced hypertension, ischemia/reperfusion injury, inflammation and immune response, platelet aggregation and retinal angiogenesis. In addition, the SUCNR1-induced increase of blood pressure may contribute to diabetic nephropathy or cardiac hypertrophy. The understanding of SUCNR1 activation, signaling pathways and functions remains largely elusive, which calls for deeper investigations. SUCNR1 shows a high potential as an innovative drug target and is probably an important regulator of basic physiology. In order to achieve the full characterization of this receptor,more specific pharmacological tools such as small-molecules modulators will represent an important asset. In this review, we describe the structural features of SUCNR1, its current ligands and putative binding pocket. We give an exhaustive overview of the known and hypothetical signaling partners of the receptor in different in vitro and in vivo systems. The link between SUCNR1 intracellular pathways and its pathophysiological roles are also extensively discussed. [less ▲]Detailed reference viewed: 38 (13 ULg) Brentano, la théorie des catégories et la définition de la substanceBoccaccini, Federico in Etudes Philosophiques (2016)Detailed reference viewed: 27 (0 ULg) Response to novely and cocaine stimulant effects: lack of stability across environments in female Swiss miceNyssen, Laura ; Brabant, Christian ; Didone, Vincent et alin Psychopharmacology (2016), 233Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model ... [more ▼]Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model novelty seeking is the "response to novelty," i.e., the levels of locomotor activity in a new environment. In rodents, a positive correlation was demonstrated between the response to novelty and several effects of drugs, especially the locomotor stimulant effects of cocaine. Objectives: The present study was designed to test in mice whether the response to novelty is stable across environments and whether its relationship with the stimulant effects of cocaine is altered by environmental changes. Experiment 1 assessed the responses to novelty of the same mice in two different novel environments. Experiment 2 tested the correlation between response to novelty and acute stimulant effects of cocaine recorded in two distinct environments. Results: The results show a weak correlation only during the first 5 min of the session between the responses to novelty measured in two distinct environments. Experiment 2 demonstrates that novelty responses and stimulant effects of cocaine are positively correlated only when both behavioral responses are measured in the same environment. In contrast, the relationship between response to novelty and acute stimulant effects of cocaine is completely lost when the behavioral responses are recorded in two different environments. Conclusions: The present results question the usual interpretation of the correlation between the response to novelty and the stimulant effects of cocaine as reflecting a relationship between two underlying individual stable characteristics. [less ▲]Detailed reference viewed: 18 (4 ULg) Nutritive value of three tropical forgae legumes and their influence on growth performance, carcass traits and organ weights of pigsKambashi Mutiaka, Bienvenu ; Kalala Bolokango, Gaetan ; Dochain, Denis et alin Tropical Animal Health and Production (2016)The effects of tropical forage legumes on feed intake, growth performance and carcass traits were investigated in 16 groups of two Large White × Duroc pigs. The diets consisted of a commercial ... [more ▼]The effects of tropical forage legumes on feed intake, growth performance and carcass traits were investigated in 16 groups of two Large White × Duroc pigs. The diets consisted of a commercial corn–soybean meal diet as the basal diet and three forage-supplemented diets. Four groups of control pigs received daily 4 % of body weight of the basal diet, and 12 groups of experimental pigs were fed the basal diet at 3.2 % of body weight completed with fresh leaves of one of the three forage legumes (Psophocarpus scandens, Stylosanthes guianensis and Vigna unguiculata) ad libitum. The study lasted 90 days. The in vitro digestion and fermentation of the forage legumes were also determined. The in vitro digestible energy content of the legumes was between 0.72 and 0.77 that of the basal diet (14.4 MJ/kg dry matter (DM)). V. unguiculata was the most digestible forage legume expected for crude protein digestibility. Feeding forage legumes lowered the dry matter intake by 4.5 to 9.6 % (P< 0.05), final body weight (P= 0.013), slaughter weight, average daily gain and hot carcass weight (P< 0.05) without affecting the feed conversion ratio (FCR), dressing percentage and back fat thickness. In conclusion, using forage to feed pig could be interesting in pig smallholder productionwith limited access to concentrate, as FCR was not significantly affected. [less ▲]Detailed reference viewed: 21 (9 ULg) Bott type periodicity for the higher octonionsKreusch, Marie in Journal of Noncommutative Geometry (2016), 9(4), 1041-1393We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions ... [more ▼]We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions and Clifford algebras. The algebras $\bbO_{n}$ and $\bbO_{p,q}$ with $p+q=n$ have a natural $\Z_2^n$-grading, and they are characterized by cubic forms over the field $\Z_2$. We establish a periodicity for the algebras~$\bbO_{n}$ and $\bbO_{p,q}$ similar to that of the Clifford algebras $\mathrm{Cl}_{n}$ and~$\mathrm{Cl}_{p,q}$. [less ▲]Detailed reference viewed: 162 (53 ULg) Impact of Serial B-Type Natriuretic Peptide Changes for Predicting Outcome in Asymptomatic Patients With Aortic Stenosis.Henri, Christine; DULGHERU, Raluca Elena ; Magne, Julien et alin The Canadian journal of cardiology (2016)BACKGROUND: The aim of this study was to determine the impact on the outcome of serial B-type natriuretic peptide (BNP) changes during follow-up in asymptomatic patients with >/= moderate aortic stenosis ... [more ▼]BACKGROUND: The aim of this study was to determine the impact on the outcome of serial B-type natriuretic peptide (BNP) changes during follow-up in asymptomatic patients with >/= moderate aortic stenosis (AS) and preserved left ventricular ejection fraction. METHODS: We prospectively screened 69 patients who underwent comprehensive transthoracic echocardiography, BNP level measurement at baseline and after every 6 or 12 months. Annualized BNP changes were calculated as the difference between the last and baseline BNP measurements divided by the duration of follow-up. The primary endpoint was the occurrence of symptoms, aortic valve replacement, or cardiovascular death. RESULTS: During a follow-up of 30 +/- 19 months, 43 patients experienced a cardiac event. These patients were significantly older (73 +/- 9 vs 65 +/- 16 years; P = 0.010), had more often dyslipidemia (79% vs 42%; P = 0.038), more severe AS (peak velocity: 3.9 +/- 0.6 vs 3.5 +/- 0.6 m/s; P = 0.002), larger indexed left atrial area (10.2 +/- 2.5 vs 8.7 +/- 1.9 cm2/m2; P = 0.006), and a higher increase in annualized BNP (+90 +/- 155 vs +7 +/- 49 pg/mL/y; P = 0.010). Patients with higher annualized BNP changes (> 20 pg/mL/y) had a significantly lower cardiac event-free survival (1 year: 63 +/- 8% vs 97 +/- 3%; 3 years: 31 +/- 8% vs 68 +/- 8%; P < 0.001). Using the multivariate Cox proportional hazards model, higher annualized BNP changes were significantly associated with increased risk of cardiac events (hazard ratio: 2.73, 95% confidence interval: 1.27-5.86; P = 0.010) after adjustment for age, dyslipidemia, and echocardiographic parameters. CONCLUSIONS: In asymptomatic patients with AS and preserved left ventricular ejection fraction, the use of serial BNP changes may help to anticipate development of class I indication for aortic valve replacement. [less ▲]Detailed reference viewed: 35 (5 ULg) Comparative virucidal efficacy of seven disinfectants against murine norovirus and feline calicivirus, surrogates of human norovirusZonta, William ; Mauroy, Axel ; Farnir, Frédéric et alin Food and Environmental Virology (2016)Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge ... [more ▼]Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge of an efficient disinfection for both hands and food contact surfaces is helpful for the food sector and provides precious information for public health. The aim of this study was to evaluate the effect of seven disinfectants belonging to different groups of biocides (alcohol, halogen, oxidizing agents, quaternary ammonium compounds, aldehyde and biguanide) on infectious viral titre and on genomic copy number. Due to the absence of a cell culture system for HuNoV, two HuNoV surrogates such as murine norovirus (MNV) and feline calicivirus (FCV), were used and the tests were performed in suspension, on gloves and on stainless steel discs. When, as criteria of efficacy, a log reduction > 3 of the infectious viral titre on both surrogates and in the three tests is used, the most efficacious disinfectants in this study appear to be biocidal products B, C and D, representing the halogens, the oxidizing agents group and a mix of QAC, alcohol and aldehyde, respectively. In addition, these three disinfectants also elicited a significant effect on genomic copy number for both surrogate viruses and in all three tests. The results of this study demonstrate that a halogen compound, oxidizing agents and a mix of QAC, alcohol and aldehyde are advisable for HuNoV disinfection of either potentially contaminated surfaces or materials in contact with foodstuffs. [less ▲]Detailed reference viewed: 37 (8 ULg) Transatlantic Editorial: A Comparison Between European and North American Guidelines on Myocardial Revascularization.Kolh, Philippe ; Kurlansky, Paul; Cremer, Jochen et alin Annals of Thoracic Surgery (2016), 101(6), 2031-44Detailed reference viewed: 8 (0 ULg) Bacterial community composition in relation to bedrock type and macrobiota in soils 1 from the Sør Rondane Mountains, East AntarcticaTytgat, Bjorn; Verleyen, Elie; Sweetlove, Maxime et alin FEMS Microbiology Ecology (2016), 92Antarctic soils are known to be oligotrophic and of having low buffering capacities. It is expected that this is particularly the case for inland high altitude regions. We hypothesized that the bedrock ... [more ▼]Antarctic soils are known to be oligotrophic and of having low buffering capacities. It is expected that this is particularly the case for inland high altitude regions. We hypothesized that the bedrock type and the presence of macrobiota in these soils enforce a high selective pressure on their bacterial communities. To test this, we analysed the bacterial community structure in 52 soil samples from the western Sør Rondane Mountains (Dronning Maud Land, East Antarctica) using the Illumina MiSeq platform in combination with ARISA fingerprinting. The samples were taken along broad environmental gradients in an area covering nearly 1000 km². Ordination and variation partitioning analyses revealed that the total organic carbon content was the most significant variable in structuring the bacterial communities, followed by pH, electric conductivity, bedrock type and the moisture content, while spatial distance was of relatively minor importance. Acidobacteria (Chloracidobacteria) and Actinobacteria (Actinomycetales) dominated gneiss derived mineral soil samples, while Proteobacteria (Sphingomonadaceae), Cyanobacteria, Armatimonadetes and candidate division FBP dominated soil samples with a high total organic carbon content that were mainly situated on granite derived bedrock. [less ▲]Detailed reference viewed: 40 (4 ULg) Human norovirus infection in Latin Americada Silva Polo, Tatiane; Peiro, Juliana; Claudio Nogueira Mendes, Luiz et alin Journal of Clinical Virology (2016), 78Detailed reference viewed: 10 (3 ULg) Tea production between contract and none contract farmers in Phu Tho Province of VietnamLe Thi Kim, Oanh ; Bui Thi, Nga; Lebailly, Philippe in Scholars Journal of Agriculture and Veterinary Sciences (2016), 3(2), 117-122Tea is one of key crops which substantially contributes to Vietnam’s annual exports, creates jobs and raises income for farmers. However, tea production farmers are still facing many difficulties such as ... [more ▼]Tea is one of key crops which substantially contributes to Vietnam’s annual exports, creates jobs and raises income for farmers. However, tea production farmers are still facing many difficulties such as low farm management, disease control, etc. Of which, tea consumption is considered to be the most challenge and the main reasons is the low cooperation between farmers and other stakeholders in the tea value chain. This study aims to look more deeply and find out the linkage and benefit of farmers in the model of cooperation between farmers and tea processing company through contract and none contract tea production in the study site. The results shown that the contract farming in tea production in the study sites was still not tightened and did not reflect clearly its real roles. However, it was gradually reflected it s roles as the fully contract farmers (worker farmers) received the highest productivity, turnover and value added and the most satisfied, the contract farmers (partly contract) achieved not as high benefit but quite satisfied with their results and contract. None contract farmers although received reasonable results recently but they still did not assure the production, they would like to engage in some kinds of cooperation in the future. [less ▲]Detailed reference viewed: 99 (20 ULg) Implicit learning: A way to improve visual search in spatial neglect?Wansard, Murielle ; Geurten, Marie ; Colson, Catherine et alin Consciousness & Cognition (2016)Studies have shown that neglect patients are able to use stimulus regularities to orient faster toward the neglected side, without necessarily being aware of that information, or at the very least without ... [more ▼]Studies have shown that neglect patients are able to use stimulus regularities to orient faster toward the neglected side, without necessarily being aware of that information, or at the very least without being able to verbalize their knowledge. In order to better control for the involvement of explicit processes, the present study sought to test neglect patients’ ability to detect more complex associations between stimuli using tasks similar to those used in implicit learning studies. Our results demonstrate that neglect patients had difficulties implicitly learning complex associations, contrary to what we found with controls. The possible influence of attentional and working memory impairments are discussed. [less ▲]Detailed reference viewed: 19 (3 ULg) Voir les fous « jouer » aux fous, puis penser la folie… : À propos de Foucault à Münsterlingen : À l’origine de l’histoire de la folieEnglebert, Jérôme ; Follet, Valériein Revue de Synthèse (2016)Detailed reference viewed: 39 (2 ULg) Examen de jurisprudence (2010-2013) - Les sociétés commerciales (première partie)Caprasse, Olivier ; Dieux, Xavier; Lambrecht, Philippein Revue Critique de Jurisprudence Belge [= RCJB] (2016)Detailed reference viewed: 25 (5 ULg) Photocatalytic decomposition of hydrogen peroxide over nanoparticles of TiO2 and Ni(II)-porphyrin doped TiO2: a relationship between activity and porphyrin anchoring modeTasseroul, Ludivine ; Pàez Martinez, Carlos ; Lambert, Stéphanie et alin Applied Catalysis B : Environmental (2016), 182The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared ... [more ▼]The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared spectroscopy and thermal gravimetry combined with differential scanning calorimetry measurements allowed the determination of the TCPPNi anchoring mode. At low TCPPNi concentrations, this anchoring on Degussa P25 TiO2 took place through all four carboxylic groups, while at higher concentrations the anchoring occurred through one or two carboxylic groups. For the firsttime,the effect of UV/vis light irradiation on the H2O2-degradation activity of TiO2 and TCPPNi-doped TiO2 was studied using the method of following the production of O2 by gas pressure monitoring. The activity of seven different catalysts was related to the TCPPNi anchoring mode and the percentage of TiO2 Degussa P25 coverage. An optimum degradation of H2O2 was observed for 0.0115 mol TCPPNi × g−1 P25. In that case, the TCPPNi was anchored through the four carboxylic groups, corresponding to a strong interaction with Degussa P25 TiO2. Moreover, the TCPPNi did not cover the surface completely, therefore allowing the light to reach and activate the TiO2. [less ▲]Detailed reference viewed: 55 (12 ULg) Influences of the aqueous synthesis way and organosilane nature on the physico-chemical properties of porous aluminaClaude, Vincent ; Vilaseca, Miriam; Tatton, Andrew et alin European Journal of Inorganic Chemistry (2016), 2016(11), 1678-1689The aqueous sol-gel synthesis of γ-Al2O3 modified with different silicon precursors {trimethoxysilane, triethoxysilane and N-[3-(trimethoxysilyl)propyl]ethylene diamine} has been investigated. Two ... [more ▼]The aqueous sol-gel synthesis of γ-Al2O3 modified with different silicon precursors {trimethoxysilane, triethoxysilane and N-[3-(trimethoxysilyl)propyl]ethylene diamine} has been investigated. Two parameters have been studied: the silicon addition step and the type of silicon alkoxide. A first observation was that adding a silicon alkoxide either before or just after the precipitation step influences both the crystallinity and structure, whereas adding the alkoxide after a long agitation time only slightly modifies the support properties. It was also highlighted that due to their higher reactivity, silicon precursors with methoxy groups interact more strongly with the bulk alumina than the silicon precursors with ethoxy groups. This difference of Si location in the alumina structure permitted not only their resistance toward phase transition to be increased at high temperature, but also to stabilize them more efficiently against sintering under normal and steam conditions. Among the different silicon alkoxides tested, samples prepared with N-[3-(trimethoxysilyl)propyl]ethylene diamine showed very unusual properties. The alumina supports modified with this precursor showed grain-shaped nanocrystallites, whereas all other samples were platelet-like. As a result, this sample presented a very narrow pore diameter distribution of around 5 nm and a remarkably high specific surface area (530 m2/g). [less ▲]Detailed reference viewed: 12 (0 ULg) Gemtuzumab Ozogamicin Versus Best Supportive Care in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Unsuitable for Intensive Chemotherapy: Results of the Randomized Phase III EORTC-GIMEMA AML-19 TrialAmadori, Sergio; Suciu, Stefan; Selleslag, Dominik et alin Journal of Clinical Oncology (2016)Purpose To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute myeloid leukemia unsuitable for ... [more ▼]Purpose To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute myeloid leukemia unsuitable for intensive chemotherapy. Patients and Methods In this trial, patients at least 61 years old were centrally randomized (1:1) to receive either a single induction course of GO (6 mg/m2 on day 1 and 3 mg/m2 on day 8) or BSC. Patients who did not progress after GO induction could receive up to eight monthly infusions of the immunoconjugate at 2 mg/m2. Randomization was stratified by age, WHO performance score, CD33 expression status, and center. The primary end point was overall survival (OS) by intention-to-treat analysis. Results A total of 237 patients were randomly assigned (118 to GO and 119 to BSC). The median OS was 4.9 months (95% CI, 4.2 to 6.8 months) in the GO group and 3.6 months (95% CI, 2.6 to 4.2 months) in the BSC group (hazard ratio, 0.69; 95% CI, 0.53 to 0.90; P = .005); the 1-year OS rate was 24.3% with GO and 9.7% with BSC. The OS benefit with GO was consistent across most subgroups, and was especially apparent in patients with high CD33 expression status, in those with favorable/intermediate cytogenetic risk profile, and in women. Overall, complete remission (CR [complete remission] + CRi [CR with incomplete recovery of peripheral blood counts]) occurred in 30 of 111 (27%) GO recipients. The rates of serious adverse events (AEs) were similar in the two groups, and no excess mortality from AEs was observed with GO. Conclusion First-line monotherapy with low-dose GO, as compared with BSC, significantly improved OS in older patients with acute myeloid leukemia who were ineligible for intensive chemotherapy. No unexpected AEs were identified and toxicity was manageable. [less ▲]Detailed reference viewed: 18 (0 ULg) Towards Generic Image Classification using Tree-based Learning: an Extensive Empirical StudyMarée, Raphaël ; Geurts, Pierre ; Wehenkel, Louis in Pattern Recognition Letters (2016)This paper considers the general problem of image classification without using any prior knowledge about image classes. We study variants of a method based on supervised learning whose common steps are ... [more ▼]This paper considers the general problem of image classification without using any prior knowledge about image classes. We study variants of a method based on supervised learning whose common steps are the extraction of random subwindows described by raw pixel intensity values and the use of ensemble of extremely randomized trees to directly classify images or to learn image features. The influence of method parameters and variants is thoroughly evaluated so as to provide baselines and guidelines for future studies. Detailed results are provided on 80 publicly available datasets that depict very diverse types of images (more than 3800 image classes and over 1.5 million images). [less ▲]Detailed reference viewed: 253 (39 ULg) compte rendu de : Serena Ammirati, Sul libro latino antico. Ricerche bibliologiche e paleografiche, Pisa-Roma, Fabrizio Serra Editore, 2015Rochette, Bruno in Athenaeum : Studii Periodici di Letteratura e Storia (2016)Detailed reference viewed: 48 (0 ULg) ON THE USE OF HIGH-THROUGHPUT SEQUENCING FOR THE STUDY OF CYANOBACTERIAL DIVERSITY IN ANTARCTIC AQUATIC MATS 1Stelmach Pessi, Igor ; De Carvalho Maalouf, Pedro; Laughinghouse, Haywood Dail et alin Journal of Phycology (2016), 52The study of Antarctic cyanobacterial diversity has been mostly limited to morphological identification and traditional molecular techniques. High-throughput sequencing (HTS) allows a much better ... [more ▼]The study of Antarctic cyanobacterial diversity has been mostly limited to morphological identification and traditional molecular techniques. High-throughput sequencing (HTS) allows a much better understanding of microbial distribution in the environment, but its application is hampered by several methodological and analytical challenges. In this work we explored the use of HTS as a tool for the study of cyanobacterial diversity in Antarctic aquatic mats. Our results highlight the importance of using artificial communities to validate the parameters of the bioinformatics procedure used to analyse natural communities, since pipeline-dependent biases had a strong effect on the observed community structures. Analysis of microbial mats from five Antarctic lakes and an aquatic biofilm from the Sub-Antarctic showed that HTS is a valuable tool for the assessment of cyanobacterial diversity. The majority of the OTUs retrieved were related to filamentous taxa such as Leptolyngbya and Phormidium, which are common genera in Antarctic lacustrine microbial mats. However, other phylotypes related to different taxa such as Geitlerinema, Pseudanabaena, Synechococcus and Chamaesiphon, Calothrix and Coleodesmium were also found. Results revealed a much higher diversity than what had been reported using traditional methods and also highlighted remarkable differences between the cyanobacterial communities of the studied lakes. The aquatic biofilm from the Sub-Antarctic had a distinct cyanobacterial community in comparison to the studied Antarctic lakes, which, in turn, displayed a salinity-dependent community-structure at the phylotype level. [less ▲]Detailed reference viewed: 29 (13 ULg) Defining multiplication in some additive expansions of polynomial ringsPoint, Françoise; Rigo, Michel ; Waxweiler, Laurentin Communications in Algebra (2016), 44Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this ... [more ▼]Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this applies to polynomial rings over a finite field. [less ▲]Detailed reference viewed: 24 (8 ULg) The radial artery for coronary artery bypass grafting: a second revival?Sousa Uva, Miguel; Kolh, Philippe in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(1), 210-1Detailed reference viewed: 19 (1 ULg) Clarifying the Socio-Economic Dimensions of Agroecology: Between Principles and PracticesDumont, Antoinette M.; Vanloqueren, Gaëtan; Stassart, Pierre M et alin Agroecology and Sustainable Food Systems (2016), 1(1), 24-47AbstractThe concept of agroecology is being mobilized increasingly. However, its socio-economic dimensions receive little attention from academia. This study helps to clarify the socio-economic principles ... [more ▼]AbstractThe concept of agroecology is being mobilized increasingly. However, its socio-economic dimensions receive little attention from academia. This study helps to clarify the socio-economic principles of agroecology by first identifying a list of principles in popular and scientific literature and, as a second step, by putting the principles to the test of a qualitative study of two Belgian organizations. Agribio is a grain cooperative, and Les Grosses L√©gumes is a network of consumers, farmers, and the members of an association set up to organize the production and distribution of vegetable boxes. Semi-directed interviews of the various actors linked to these organizations were conducted and then analyzed through an approach inspired by the convention theory in order to reveal the principles that the stakeholders have adopted. The main findings are then made explicit by analysis of four strong agreements (which concern the two organizations? marketing schemes, a Participatory Guarantee System set up by Les Grosses L√©gumes and Agribio?s flour mill). The two case studies show the gap that exists between the principles that describe the horizon of agroecology and the principles that are actually put into practice by the parties in the field through various transition pathways. [less ▲]Detailed reference viewed: 102 (19 ULg) Prophylactic donor lymphocyte infusion in patients with high-risk acute myeloid leukemia: ready for prime time?Baron, Frédéric ; Beguin, Yves in Bone Marrow Transplantation (2016), 51Detailed reference viewed: 61 (2 ULg) Mises en scènes auctoriales autour de la publication d'OedipeDaubercies, Laurence in Revue Voltaire (2016), 16Detailed reference viewed: 12 (0 ULg) Chasing the Dioxin Detection DragonFocant, Jean-François in The Analytical Scientist (2016), 0316-701Detailed reference viewed: 9 (2 ULg) Non-monotonous anisotropy in charge conduction induced by antiferrodistortive transition in metallic SrTiO3Tao, Qian; Loret, Bastien; Xu, Bin et alin Physical Review B (2016), 94Detailed reference viewed: 46 (5 ULg) Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH cells.Rotondi, Sandra; Modarelli, Alessio; Oliva, Maria-Antonietta et alin Molecular and cellular endocrinology (2016)PURPOSE: To search for a possible role of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha), a molecular partner of the Aryl hydrocarbon receptor Interacting Protein (AIP), in somatotropinomas ... [more ▼]PURPOSE: To search for a possible role of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha), a molecular partner of the Aryl hydrocarbon receptor Interacting Protein (AIP), in somatotropinomas. METHODS: Tumours from 51 acromegalic patients were characterized for PPARalpha and AIP expression by immunohistochemistry (IHC) and/or Real Time RT-PCR. Data were analysed according to tumour characteristics and pre-operative treatment with somatostatin analogues (SSA). The effects of fenofibrate were studied in GH3 cells in vitro. RESULTS: PPARalpha was expressed in most somatotropinomas. A modest relationship was found between PPARalpha and AIP expression, both being significantly higher in the presence of pre-operative SSA. However, only AIP expression was influenced by the response to treatment. Dual effects of fenofibrate were observed in GH3 cells, consisting of cell growth inhibition and an increase in GH secretion inhibited by octreotide. CONCLUSIONS: PPARalpha is a new player in somatotropinomas. Potential interactions between PPARalpha agonists and SSA may deserve further investigation. [less ▲]Detailed reference viewed: 21 (5 ULg) Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imagingHenrottin, Jean ; Lemaire, Christian ; Egrise, Dominique et alin Nuclear Medicine & Biology (2016)Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor ... [more ▼]Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor tissues by blocking locally T-lymphocyte proliferation. Recently, 1-(2-[19F]fluoroethyl)-DL-tryptophan (1-[19F]FE-DL-Trp) was reported as a good and specific substrate of this enzyme. Herein, the radiosynthesis of its radioactive isotopomer (1-[18F]FE-DL-Trp, DL-[18F]5) is presented along with in vitro enzymatic and cellular uptake studies. Methods: The one-pot n.c.a. radiosynthesis of this novel potential PET imaging tracer, including HPLC purification and formulation, has been fully automated on a FASTlabTM synthesizer. Chiral separation of both isomers and their formulation were implemented on a second cassette. In vitro enzymatic and cellular uptake studies were then conducted with the D-, L- and DL-radiotracers. Results: The radiolabeling of the tosylate precursor was performed in DMF (in 5 min; RCY: 57% (d.c.), n=3). After hydrolysis, HPLC purification and formulation, DL-[18F]5 was obtained with a global radiochemical yield of 18±3% (not decay corrected, n=7, in 80 min) and a specific activity of 600±180 GBq/µmol (n=5). The subsequent separation of L- and D-enantiomers was performed by chiral HPLC and both were obtained after formulation with a RCY (d.c.) of 6.1% and 5.8%, respectively. In vitro enzymatic assays reveal that L-[18F]5 is a better substrate than D-[18F]5 for human IDO. In vitro cellular assays show an IDO-specific uptake of the racemate varying from 30% to 50% of that of L-[18F]5, and a negligible uptake of D-[18F]5. Conclusion: In vitro studies show that L-[18F]5 is a good and specific substrate of hIDO, while presenting a very low efflux. These results confirm that L-[18F]5 could be a very useful PET radiotracer for IDO expressing cells in cancer imaging. [less ▲]Detailed reference viewed: 55 (12 ULg) Abelian bordered factors and periodicityCharlier, Emilie ; Harju, Tero; Puzynina, Svetlana et alin European Journal of Combinatorics (2016), 51A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only ... [more ▼]A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only if it contains only finitely many unbordered factors. We are interested in abelian and weak abelian analogues of this result; namely, we investigate the following question(s): Let w be an infinite word such that all sufficiently long factors are (weakly) abelian bordered; is w (weakly) abelian periodic? In the process we answer a question of Avgustinovich et al. concerning the abelian critical factorization theorem. [less ▲]Detailed reference viewed: 38 (8 ULg) A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis - From evidence-based medicine to the real-life setting.Bruyère, Olivier ; Cooper, C.; Pelletier, J.P. et alin Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 3-11The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides ... [more ▼]The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides practical guidance for the prioritization of interventions. Further analysis of real-world data for OA provides additional evidence in support of pharmacological interventions,in terms of management of OA pain and function, avoidance of adverse events, disease-modifying effects and long-term outcomes, e.g., delay of total joint replacement surgery, and pharmacoeconomic factors such as reduction in healthcare resource utilization. This article provides an updated assessment of the literature for selected interventions in OA, focusing on real-life data, with the aim of providing easy-to-follow advice on how to establish a treatment flow in patients with knee OA in primary care clinical practice, in support of the clinicians’ individualized assessment of the patient. In step 1, background maintenance therapy with symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) is recommended, for which high-quality evidence is provided only for the prescription formulations of patented crystalline glucosamine sulfate and chondroitin sulfate. Paracetamol may be added for rescue analgesia only,due to limited efficacy and increasing safety signals. Topical non-steroidal anti-inflammatory drugs (NSAIDs) may provide additional symptomatic treatment with the same degree of efficacy as oral NSAIDs without the systemic safety concerns. Oral NSAIDs maintain a central role in step2 Advanced management of persistent symptoms. However, oral NSAIDs are highly heterogeneous in terms of gastrointestinal and cardiovascular safety profile, and patient stratification with careful treatment selection is advocated to maximize the risk: benefit ratio. Intra-articular hyaluronic acid as a next step provides sustained clinical benefit with effects lasting up to 6 months after a short-course of weekly injections. As a last step before surgery, thes low titration of sustained-release tramadol, aweak opioid, affords sustained analgesia with improved tolerability. [less ▲]Detailed reference viewed: 27 (12 ULg) Development of Fourier transform mid-infrared calibrations to predict acetone, β-hydroxybutyrate, and citrate contents in bovine milk through a European dairy networkGrelet, Clément ; Bastin, Catherine ; Gele, M et alin Journal of Dairy Science (2016), 99(6), 4816-4825Detailed reference viewed: 51 (23 ULg) Surface Constrained Elastic Rods with Application to the SphereHuynen, Alexandre ; Detournay, Emmanuel; Denoël, Vincent in Journal of Elasticity (2016)The unilateral contact between an elastic rod and a rigid surface is encountered in numerous biological and engineering applications. Along continuous contacts, the centerline of the rod reflects the ... [more ▼]The unilateral contact between an elastic rod and a rigid surface is encountered in numerous biological and engineering applications. Along continuous contacts, the centerline of the rod reflects the geometry of the constraining surface. This restriction of the rod axis to surface bound configurations enters its local equilibrium through a reaction pressure which ensures the compatibility between the deformation and the restraint geometry. The classic equations governing the static equilibrium of elastic rods are particularized to surface bound configurations by (i) specifying the location of the rod axis in terms of its coordinates in the parameter space associated with the constraining surface parameterization, and (ii) characterizing the orientation of its material frame through its rotation with respect to the surface normal. This formulation, which emphasizes the relations between the rod configuration and the geometry of the constraint, also leads to an expression for the reaction pressure. This approach is then validated on a spherical surface by comparing with known solutions for elastic curves, i.e., inextensible and twist free rods. [less ▲]Detailed reference viewed: 49 (10 ULg) Can breeder reproductive status, performance and egg quality be enhanced by supplementation and transition of n-3 fatty acids?Delezie, E.; Koppenol, A.; Buyse, J. et alin Journal of Animal Physiology and Animal Nutrition (2016)Summary: The aim of this experiment was to investigate the effect of n-3 fatty acid (FA) supplemented diets on breeder performance, productivity and egg quality. Breeders (n = 480) were fed the ... [more ▼]Summary: The aim of this experiment was to investigate the effect of n-3 fatty acid (FA) supplemented diets on breeder performance, productivity and egg quality. Breeders (n = 480) were fed the supplemented diet from 18 weeks onwards; the inclusion level of n-3 FA was increased from 1.5% to 3.0% from 34 weeks of age onwards until 48 weeks of age. Ross-308 broiler breeders (n = 480) were fed one of four different diets: a basal diet rich in n-6 FA (control diet) or one of three diets rich in n-3 FA. For the n-3 FA diets, eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) were fed to the broiler breeders at different ratios formulated to obtain EPA/DHA ratios of 1/1, 1/2 or 2/1. Differences in performance, reproduction and egg quality parameters due to n-3 supplementation were noted more for the 1.5% followed by the 3.0% fed broilers than their 1.5% supplemented counterparts. Egg weight (p < 0.001) and egg mass (p = 0.003) were significantly lower and feed conversion (p = 0.008) significantly higher for the n-3 FA (at 3.0% inclusion level) fed broilers compared to the control group. For the EPA- and DHA-fed breeders, a higher proportional abdominal fat percentage (p = 0.025) and proportional albumen weight (%) (p = 0.041) were found respectively. Dietary treatments did not affect reproduction. It can be concluded that the results of the present experiment indicate no significant differences between treatments at 1.5% inclusion levels. However, increasing this level to 3.0% is not recommended due to the rather negative effects on the measured parameters. It should be further investigated whether these adverse effects were obtained due to (i) the higher supplementation level, (ii) combining a supplementation level of 1.5% with 3% or (iii) the duration of supplementation. © 2016 Blackwell Verlag GmbH. [less ▲]Detailed reference viewed: 17 (1 ULg) Examen de jurisprudence (2010-2013) - Les sociétés commerciales (première partie)Léonard, Laura ; Caprasse, Olivier; Dieux, Xavier et alin Revue Critique de Jurisprudence Belge [= RCJB] (2016), (1), Detailed reference viewed: 26 (3 ULg) Evaluation of a New Method for the Treatment of Invasive, Diffuse, and Unexcisable Lymphangiomas of the Oral Cavity with Defocus CO2 Laser Beam: A 20-Year Follow-UpNamour, Samir ; VAN HEUSDEN, Alain ; Namour, Amaury et alin Photomedicine and Laser Surgery (2016), 34(2), 82-87Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and ... [more ▼]Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and unexcisable oral lymphangiomas. Background data: Cystic lymphatic malformations, or lymphangiomas, are mature lymphatic malformations, consisting of abnormal lymphatic vessels. Surgical excision is considered by most surgeons to be the treatment of choice for lymphangioma. Laser beam has been used to treat superficial or small lymphatic malformations by excision or by photocoagulation, and to excise or photocoagulate small lymphangiomas. Patients and methods: Seventeen patients with diffuse and unexcisable lymphangiomas were treated using a CO2 laser with specific settings: beam was 2W in noncontact and defocus mode, power density was 0.63W/cm2 for irradiation time in the range of 3– 5min, and the estimated energy density range was 114.65–191.02 J/cm2. The beam diameter at the tissular impact point was –2 cm. The laser beam was defocused to provoke a deep heat generation that would dry up the lymphatic tissues and induce deep tissue necrosis that heals by fibrous tissue process. Results: The results were satisfactory and stable, with localized recurrence in three cases. The recurrent areas were re-treated using the same technique successfully and with no further recurrence. Conclusions: The use of CO2 laser under the suggested irradiation conditions can be considered a useful technique for the treatment of invasive lymphangiomas. [less ▲]Detailed reference viewed: 14 (2 ULg) Doped sol–gel films vs. powders TiO2: On the positive effect induced by the presence of a substrateLéonard, Géraldine ; Malengreaux, Charline; Melotte, Quentin et alin Journal of Environmental Chemical Engineering (2016), 4SiO2 and Ag–SiO2 doped TiO2 films and powders have been produced using a controlled sol–gel process. The dopant has been introduced using an alkoxysilane-functionalized ligand, with or without complexed ... [more ▼]SiO2 and Ag–SiO2 doped TiO2 films and powders have been produced using a controlled sol–gel process. The dopant has been introduced using an alkoxysilane-functionalized ligand, with or without complexed silver ions. The influence of dopants on physico-chemical properties of the catalysts is studied by XRD, TEM–EDX, DRUV–vis analyses in the case of powders, while GIXRD, XPS, profilometry, UV–vis absorption analyses have been used for thin films. The photocatalytic activity has been evaluated from the degradation of methylene blue under UV-A light in the presence of the different catalysts over a period of 24 h. The detailed comparison between powders and films highlights a surprising positive effect in the case of films due to the presence of the substrate. In the case of photocatalytic powders, the presence of SiO2 or Ag–SiO2 into the TiO2 matrix has a detrimental effect on the photocatalytic activity while the opposite tendency is observed in the case of films, with best activities obtained with Ag–SiO2 doping. Different factors, in particular crystallinity modification between powders and films, have been studied to explain these opposite behaviors. In the case of powders, crystallization is hindered by SiO2 and Ag particles incorporation into the TiO2 matrix, leading to a decrease of the photocatalytic activity. In the case of thin films, probably because of the presence of a substrate, crystallization is not influenced by the presence of SiO2 and Ag particles. Therefore, the latter ones can fully play their role of electron traps leading to an enhanced photocatalytic activity. [less ▲]Detailed reference viewed: 71 (12 ULg) Absence of selenium protection against methylmercury toxicity in harbour seal leucocytes in vitroDas, Krishna ; Dupont, Aurélie; De Pauw-Gillet, Marie-Claire et alin Marine Pollution Bulletin (2016), 108Previous studies described high concentrations of mercury (Hg) and selenium (Se) in the blood of harbour seals, Phoca vitulina from the North Sea. In the present study, we evaluated the in vitro potential ... [more ▼]Previous studies described high concentrations of mercury (Hg) and selenium (Se) in the blood of harbour seals, Phoca vitulina from the North Sea. In the present study, we evaluated the in vitro potential protective effects of sodium selenite (Na2SeO3) and selenomethionine (SeMet) on cell proliferation of harbour seal lymphocytes exposed to MeHgCl 0.75 µM. In vitro exposure of ConA-stimulated T lymphocytes resulted in severe inhibition of DNA synthesis, likely linked to severe loss of mitochondrial membrane potential at 0.75 µM. Neither selenite nor SeMet showed a protective effect against MeHg toxicity expressed at the T lymphocyte proliferation level for harbour seals. Selenite and SeMet did not show negative effects regarding lymphocyte proliferation and mitochondrial membrane potential. To conclude, our results clearly demonstrated that MeHg affected in vitro immune cells exposure with no protective effects of selenium at a molar ratio Hg:Se of 1:10 in harbour seals from the North Sea. [less ▲]Detailed reference viewed: 11 (6 ULg) Environmental and economic beneﬁts of variable rate nitrogen fertilization in a nitrate vulnerable zoneBasso, Bruno; Dumont, Benjamin ; Cammarano, Davide et alin Science of the Total Environment (2016), 545/546Agronomic input and management practices have traditionally been applied uniformly on agricultural ﬁelds despite the presence of spatial variability of soil properties and landscape position. When spatial ... [more ▼]Agronomic input and management practices have traditionally been applied uniformly on agricultural ﬁelds despite the presence of spatial variability of soil properties and landscape position. When spatial variability is ignored, uniform agronomic management can be both economically and environmentally inefﬁcient. The objectives of this study were to: i) identify optimal N fertilizer rates using an integrated spatio-temporal analysis of yield and site-speciﬁc N rate response; ii) test the sensitivity of site speciﬁc N management to nitrate leaching in response to different N rates; and iii) demonstrate the environmental beneﬁts of variable rate N fertilizer in a Nitrate Vulnerable Zone. This study was carried out on a 13.6 ha ﬁeld near the Venice Lagoon, northeast Italy over four years (2005–2008). We utilized a validated crop simulation model to evaluate crop response to different N rates at speciﬁc zones in the ﬁeld based on localized soil and landscape properties under rainfed conditions. The simulated rates were: 50 kg N ha -1 applied at sowing for the entire study area and increasing fractions, ranging from 150 to 350 kg N ha -1 applied at V6 stage. Based on the analysis of yield maps from previous harvests and soil electrical resistivity data, three management zones were deﬁned. Two N rates were applied in each of these zones, one suggested by our simulation analysis and the other with uniform N fertilization as normally applied by the producer. N leaching was lower and net revenue was higher in the zones where variable rates of N were applied when compared to uniform N fertilization. This demonstrates the efﬁcacy of using crop models to determine variable rates of N fertilization within a ﬁeld and the application of variable rate N fertilizer to achieve higher proﬁt and reduce nitrate leaching. [less ▲]Detailed reference viewed: 33 (2 ULg) Monitoring the freshness of fish: development of a qPCR method applied to MAP chilled whitingDehaut, Alexandre; Krzewinski, Frédéric; Grard, Thierry et alin Journal of the Science of Food and Agriculture (2016)Detailed reference viewed: 16 (1 ULg) Reconstruction of the Evolutionary History and Dispersal of Usutu Virus, a Neglected Emerging Arbovirus in Europe and Africa.Engel, Dimitri; Jost, Hanna; Wink, Michael et alin mBio (2016), 7(1), Usutu virus (USUV), one of the most neglected Old World encephalitic flaviviruses, causes epizootics among wild and captive birds and sporadic infection in humans. The dynamics of USUV spread and ... [more ▼]Usutu virus (USUV), one of the most neglected Old World encephalitic flaviviruses, causes epizootics among wild and captive birds and sporadic infection in humans. The dynamics of USUV spread and evolution in its natural hosts are unknown. Here, we present the phylogeny and evolutionary history of all available USUV strains, including 77 newly sequenced complete genomes from a variety of host species at a temporal and spatial scaled resolution. The results showed that USUV can be classified into six distinct lineages and that the most recent common ancestor of the recent European epizootics emerged in Africa at least 500 years ago. We demonstrated that USUV was introduced regularly from Africa into Europe in the last 50 years, and the genetic diversity of European lineages is shaped primarily by in situ evolution, while the African lineages have been driven by extensive gene flow. Most of the amino acid changes are deleterious polymorphisms removed by purifying selection, with adaptive evolution restricted to the NS5 gene and several others evolving under episodic directional selection, indicating that the ecological or immunological factors were mostly the key determinants of USUV dispersal and outbreaks. Host-specific mutations have been detected, while the host transition analysis identified mosquitoes as the most likely origin of the common ancestor and birds as the source of the recent European USUV lineages. Our results suggest that the major migratory bird flyways could predict the continental and intercontinental dispersal patterns of USUV and that migratory birds might act as potential long-distance dispersal vehicles. IMPORTANCE: Usutu virus (USUV), a mosquito-borne flavivirus of the Japanese encephalitis virus antigenic group, caused massive bird die-offs, mostly in Europe. There is increasing evidence that USUV appears to be pathogenic for humans, becoming a potential public health problem. The emergence of USUV in Europe allows us to understand how an arbovirus spreads, adapts, and evolves in a naive environment. Thus, understanding the epidemiological and evolutionary processes that contribute to the emergence, maintenance, and further spread of viral diseases is the sine qua non to develop and implement surveillance strategies for their control. In this work, we performed an expansive phylogeographic and evolutionary analysis of USUV using all published sequences and those generated during this study. Subsequently, we described the genetic traits, reconstructed the potential pattern of geographic spread between continents/countries of the identified viral lineages and the drivers of viral migration, and traced the origin of outbreaks and transition events between different hosts. [less ▲]Detailed reference viewed: 23 (1 ULg) Les ambiguïtés de l’anthropomorphisme : de la divinité agissante à sa statue dans la céramique grecqueCollard, Hélène in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2016), 5L’image, sous ses divers aspects, a joué un rôle essentiel dans la vie des anciens Grecs, en particulier dans le domaine religieux, puisque elle était l’une des modalités de perception du divin. En Grèce ... [more ▼]L’image, sous ses divers aspects, a joué un rôle essentiel dans la vie des anciens Grecs, en particulier dans le domaine religieux, puisque elle était l’une des modalités de perception du divin. En Grèce, la figuration anthropomorphe des dieux est largement majoritaire. Toutefois, en se tournant vers un support particulier, le vase peint, et un type de représentation particulier, la statue divine, on montrera ici que l’anthropomorphisme a pu amener une certaine ambiguïté. Dans la céramique, les représentations de statues fonctionnent sur plusieurs modes, selon la chronologie. C’est ce que l’on propose d’analyser, en examinant un groupe de vases décorés d’un thème semblable et sur lesquels une divinité est représentée, mais soit sous la forme d’une figure « vivante », soit d’une statue plus ou moins bien caractérisée. Cette étude permettra d’aborder les concepts de « fixité » et de « mouvement » de/dans l’image, mais aussi d’explorer quelques pistes de réflexions sur l’image divine et, plus largement, sur les modes de représentation du divin en Grèce ancienne. [less ▲]Detailed reference viewed: 85 (3 ULg) Fuel cell electrodes from organometallic platinum precursors: an easy atmospheric plasma approachMerche, Delphine; Dufour., Thierry; Baneton, Joffrey et alin Plasma Processes and Polymers (2016), 13Detailed reference viewed: 77 (8 ULg) Assessment of partial coalescence in whippable oil-in-water food emulsionsPetrut, Raul Flaviu ; Danthine, Sabine ; Blecker, Christophe in Advances in Colloid and Interface Science (2016), (229), 25-33Partial coalescence influences to a great extent the properties of final food products such as ice cream and whipped toppings. In return, the partial coalescence occurrence and development are conditioned ... [more ▼]Partial coalescence influences to a great extent the properties of final food products such as ice cream and whipped toppings. In return, the partial coalescence occurrence and development are conditioned, in such systems, by the emulsion's intrinsic properties (e.g. solid fat content, fat crystal shape and size), formulation (e.g. protein content, surfactants presence) and extrinsic factors (e.g. cooling rate, shearing). A set of methods is available for partial coalescence investigation and quantification. These methods are critically reviewed in this paper, balancing the weaknesses of themethods in terms of structure alteration (for turbidity, dye dilution, etc.) and assumptions made for mathematical models (for particle size determination) with their advantages (good repeatability, high sensitivity, etc.).With the methods proposed in literature, the partial coalescence investigations can be conducted quantitatively and/or qualitatively. Good correlation were observed between some of the quantitative methods such as dye dilution, calorimetry, fat particle size;while a poor correlation was found in the case of solvent extraction method with other quantitativemethods. The most suitableway for partial coalescence quantification was implied to be the fat particle size method, which would give results with a high degree of confidence if used in combination with a microscopic technique for the confirmation of partial coalescence as the main destabilization mechanism. [less ▲]Detailed reference viewed: 19 (2 ULg) Production, purification and characterization of a novel cold-active superoxide dismutase from the Antarctic strain Aspergillus glaucus 363Abrashev, R.; Feller, Georges ; Kostadinova, N. et alin Fungal Biology (2016), 120Detailed reference viewed: 17 (6 ULg) Searching for consensus among physicians involved in the management of sick-listed workers in the Belgian health care sector: a qualitative study among practitioners and stakeholdersVanmeerbeek, Marc ; Govers, Patrick ; Schippers, Nathalie et alin BMC Public Health (2016), 16Background In Belgium, the management of sick leave involves general practitioners (GPs), occupational health physicians (OPs) and social insurance physicians (SIPs). A dysfunctional relationship among ... [more ▼]Background In Belgium, the management of sick leave involves general practitioners (GPs), occupational health physicians (OPs) and social insurance physicians (SIPs). A dysfunctional relationship among these physicians can impede a patient’s ability to return to work. The objective of this study was to identify ways to improve these physicians’ mutual collaboration. Methods Two consensus techniques were successively performed among the three professional groups. Eight nominal groups (NGs) gathered 74 field practitioners, and a two-round Delphi process involved 32 stakeholders. Results From the results, it appears that two areas (reciprocal knowledge and evolution of the legal and regulatory framework) are objects of consensus among the three medical group that were surveyed. Information transfer, particularly electronic transfer, was stressed as an important way to improve. The consensual proposals regarding interdisciplinary collaboration indicate specific and practical changes to be implemented when professionals are managing workers who are on sick leave. The collaboration process appeared to be currently more problematic, but the participants correctly identified the need for common training. Conclusions The three physician groups all agree regarding several inter-physician collaboration proposals. The study also revealed a latent conflict situation among the analysed professionals that can arise from a lack of mutual recognition. Practical changes or improvements must be included in an extended framework that involves the different determinants of interdisciplinary collaboration that are shown by theoretical models. Collaboration is a product of the actions and behaviours of various partners, which requires reciprocal knowledge and trust; collaboration also implies political and economic structures that are led by public health authorities. [less ▲]Detailed reference viewed: 24 (4 ULg) Targeted control of the saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), and the benefits of good control of this pest to winter wheat yieldCensier, Florence ; Chavalle, Sandrine ; San Martin y Gomez, Gilles et alin Pest Management Science (2016)BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe ... [more ▼]BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe damage in cereals. In 2012 and 2013, field trials were conducted in heavily infested fields to assess its impact on winter wheat crops and to determine efficient ways of dealing with severe infestations. RESULTS: Crop exposure to H. marginata varied with the different protection methods tried. These methods included one to four successive applications of lambda-cyhalothrin. Yield losses were significant, reaching 6% in 2012 and as high as 15% in 2013, and these losses were linearly related to the number of galls on stems. CONCLUSION: The trials showed that insecticide applications needed to be synchronized with H. marginata flight peaks and to target the egg hatching period. They also revealed that insecticides applied to coincide with the first flight could, in humid conditions, also reach the larvae close to the soil surface, prior to their pupation. [less ▲]Detailed reference viewed: 58 (15 ULg) Trophic ecology of the seagrass-inhabiting footballer demoiselle Chrysiptera annulata (Peters, 1855); comparison with three other reef-associated damselfishesLepoint, Gilles ; Michel, Loïc ; Parmentier, Eric et alin Belgian Journal of Zoology (2016), 146(1), 21-32Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming ... [more ▼]Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming behavior, from almost non territorial to monoculture farmers. In addition, few species inhabit seagrass meadows but, presently, none can be considered as seagrass-eating specialists. The footballer demoiselle, Chrysiptera annulata, is found in the seagrass meadows on the reef flat of the Great Reef of Toliara (Madagascar, Mozambique Channel). Regarding this unusual habitat for pomacentrid, this study aimed to answer 3 questions: 1) What is the diet of C. annulata? 2) Do the resources supporting this diet include seagrass? 3) Does its trophic niche overlap those of other sympatric damselfishes (Pomacentrus trilineatus, Chrysiptera unimaculata and Plectroglyphidodon lacrymatus) living in close association with macrophytes or eating algae? Stomach content examination and stable isotope analysis showed that the footballer demoiselle is not a seagrass consumer but is an omnivorous/herbivorous species heavily relying on algal resources and small invertebrates. SIAR, a stable isotope mixing model, indicated it assimilated large amount of turf algae and various benthic or planktonic invertebrates in lower proportions. SIBER metrics pointed out that isotopic niche of the footballer demoiselle partly overlaps the one of its congeneric C. unimaculata, but not those of P. trilineatus and P. lacrymatus. Trophic strategies of C. annulata differed both from farming species such as P. lacrymatus or from less territorial herbivores such as P. trilineatus. Its seagrass meadow habitat on the Great Reef of Toliara allow the conquest of an unusual habitat for damselfishes and could limit competition with C. unimaculata, a species displaying the same territorial behavior and the same isotopic niche but living on the reef itself. [less ▲]Detailed reference viewed: 59 (18 ULg) Kinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35.Marcoccia, Francesca; Bottoni, Carlo; Sabatini, Alessia et alin Antimicrobial agents and chemotherapy (2016), 60(4), 2366-72Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized ... [more ▼]Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized, and their kinetic parameters were compared with those of the NDM-1 wild type. Thekcat,Km, andkcat/Kmvalues calculated for the two mutants were slightly different from those of the wild-type enzyme. Interestingly, thekcat/Kmof NDM-1(I35S)for loracarbef was about 14-fold higher than that of NDM-1. Far-UV circular dichroism (CD) spectra of NDM-1 and NDM-1(I35T)and NDM-1(I35S)enzymes suggest local structural rearrangements in the secondary structure with a marked reduction of alpha-helix content in the mutants. [less ▲]Detailed reference viewed: 17 (5 ULg) Clostridium difficile in foods and animals: A comprehensive reviewRodriguez Diaz, Cristina ; Taminiau, Bernard ; Van Broeck, Johan et alin Advances in Experimental Medicine and Biology (2016), 27Detailed reference viewed: 38 (2 ULg) Simultaneous multi-scale and multi-instrument observations of Saturn's aurorae during the 2013 observing campaignMelin, H.; Badman, S.; Stallard, T. et alin Icarus (2016)Detailed reference viewed: 9 (1 ULg) A comparison of a tablet version of the Quality of Life Systemic Inventory for Children (QLSI-C) to the standard paper versionToucheque, Malorie ; Etienne, Anne-Marie ; Missotten, Pierre et alin Psychological Assessment (2016), 28(6), 780-785Integration of e-Health technologies for purposes of both assessment and intervention has recently become an interest area in pediatric psychology. The purpose of this study is to present psychometric ... [more ▼]Integration of e-Health technologies for purposes of both assessment and intervention has recently become an interest area in pediatric psychology. The purpose of this study is to present psychometric characteristics of a technology-based (i.e., tablet administration) approach for measuring quality of life (QOL) in children. Eighty children (8-12 years) completed the Quality of Life Systemic Inventory for Children (QLSI-C) twice over a two-week delay, in a crossover design that used paper and tablet-based modes of administration. Equivalence of scores across methods was examined using Intraclass correlation coefficients (ICC), augmented by paired t-test and Pearson’s correlations. Test-retest reliability was assessed using paired t-test and Pearson’s correlations while internal consistency was assessed using Cronbach’s coefficient. Results showed a good concordance across methods of administration (ICCs = .72 to .91; r = .56 to .83). Paired t-test showed no significant differences between the tablet and paper version of the QLSI-C. Internal consistency reliability yielded acceptable Cronbach’s alphas for all QLSI-C scores, with all α >.70. Test-retest reliability for the tablet-administered QLSI-C was good (r = .66 to .90). Paired t-test showed no significant difference between time 1 and 2 for the QLSI-C scores, except for the state score. Findings established the reliability of the tablet-administered QLSI-C scores. This technology approach to assessment is more attractive for children, decreases time for administration, and enhances the ease of scoring. These advantages might encourage both clinicians and researchers to consider using e-Health developments in assessment in pediatric psychology. [less ▲]Detailed reference viewed: 77 (14 ULg) A Belgian Survey on Geriatric Assessment in Oncology Focusing on Large-Scale Implementation and Related Barriers and Facilitators.Kenis, C.; Heeren, P.; Decoster, L. et alin The journal of nutrition, health & aging (2016), 20(1), 60-70OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for ... [more ▼]OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for implementing GA in this setting. Design / setting / participants: The principal investigator of every participating hospital (n=22) was invited to complete a newly developed questionnaire with closed- and open-ended questions. The closed-ended questions surveyed how GA was implemented. The open-ended questions identified barriers and facilitators for the implementation of GA in daily oncology practice. Descriptive statistics and conventional content analysis were performed as appropriate. RESULTS: Qualifying criteria (e.g. disease status and cancer type) for GA varied substantially between hospitals. Thirteen hospitals (59.1%) succeeded to screen more than half of eligible patients. Most hospitals reported that GA data and follow-up data had been collected in almost all screened patients. Implementing geriatric recommendations and formulating new geriatric recommendations at the time of follow-up are important opportunities for improvement. The majority of identified barriers were organizational, with high workload, lack of time or financial/staffing problems as most cited. The most cited facilitators were all related to collaboration. CONCLUSION: Interventions to improve the implementation of GA in older patients with cancer need to address a wide range of factors, with organization and collaboration as key elements. All stakeholders, seeking to improve the implementation of GA in older patients with cancer, should consider and address the identified barriers and facilitators. [less ▲]Detailed reference viewed: 13 (5 ULg) Formulation of a 1D finite element of heat exchanger for accurate modelling of the grouting behaviour: Application to cyclic thermal loadingCerfontaine, Benjamin ; Radioti, Georgia ; Collin, Frédéric et alin Renewable Energy : An International Journal (2016), 96This paper presents a comprehensive formulation of a finite element for the modelling of borehole heat exchangers. This work focuses on the accurate modelling of the grouting and the field of temperature ... [more ▼]This paper presents a comprehensive formulation of a finite element for the modelling of borehole heat exchangers. This work focuses on the accurate modelling of the grouting and the field of temperature near a single borehole. Therefore the grouting of the BHE is explicitly modelled. The purpose of this work is to provide tools necessary to the further modelling of thermo-mechanical couplings. The finite element discretises the classical governing equation of advection-diffusion of heat within a 1D pipe connected to ground nodes. Petrov-Galerkin weighting functions are used to avoid numerical disturbances. The formulation is able to capture highly transient and steady-state phenomena. The proposed finite element is validated with respect to analytical solutions. An example consisting of a 100 m depth U-pipe is finally simulated. A first continuous heating simulation highlights the nonsymmetric distribution of temperature inside and near the borehole. An estimation of the error on the results as a function of the resolution parameters is also carried out. Finally simulations of cyclic thermal loading exhibit the need to take into account all daily variations if the grouting behaviour must be modelled. This is true especially in case of freeze-thaw damaging risk. [less ▲]Detailed reference viewed: 43 (7 ULg) Physico-chemical properties and amino acid profiles of sap from Tunisian date palmMakhouf-Gafsi, Ines; Mokni-Ghribi, Abir; Brahim, Bchir et alin Scientia Agricola (2016), 73(1), 85-90Date palm sap (Phoenix dactylifera L.), also known as "legmi", is a fresh juice ex¬tracted from date palm trees. The present study aimed to elucidate the effects of collection time (at the beginning of ... [more ▼]Date palm sap (Phoenix dactylifera L.), also known as "legmi", is a fresh juice ex¬tracted from date palm trees. The present study aimed to elucidate the effects of collection time (at the beginning of the tapping period and after seven days of collection) on the amino acid profile and physico-chemical properties of date palm sap from both male and female trees. Dry matter, protein, amino acid, and sugar profiles were determined using the Kjeldahl method, High-Performance Liquid Chromatography (HPLC), and High-Performance Anion-Exchange Chro¬matography with Pulsed Amperometric Detection (HPAEC-PAD), respectively. Date palm sap from both male and female trees contained high levels of carbohydrates. HPLC analysis showed that this fraction was dominated by sucrose in the sap sample from female trees compared to that from male trees. Male date palm sap was noted to exhibit lower dry matter content than female date palm sap but higher protein, total polyphenol, ash, and amino acid contents. While the major essential amino acids in the sap from male trees consisted of valine and threonine, they were represented by lysine and phenylalanine in sap samples from female trees. Further, Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) analysis showed the presence of a proteinic band of 30 kDa only for the sap from male trees. Taken together, the sap from both male and female date palm trees had a number of properties that are highly valued by the functional food industry. [less ▲]Detailed reference viewed: 33 (2 ULg) EACVI appropriateness criteria for the use of cardiovascular imaging in heart failure derived from European National Imaging Societies voting.Garbi, Madalina; Edvardsen, Thor; Bax, Jeroen et alin European heart journal cardiovascular Imaging (2016)This paper presents the first European appropriateness criteria for the use of cardiovascular imaging in heart failure, derived from voting of the European National Imaging Societies representatives. The ... [more ▼]This paper presents the first European appropriateness criteria for the use of cardiovascular imaging in heart failure, derived from voting of the European National Imaging Societies representatives. The paper describes the development process and discusses the results. [less ▲]Detailed reference viewed: 12 (1 ULg) Réparation des ouvrages en béton armé - Partie 2 : Compatibilité et performancesCourard, Luc ; Bissonnette, Benoîtin Techniques de l'Ingénieur. Analyse Chimique et Caractérisation (2016)La réparation des bétons nécessite non seulement une bonne connaissance du support à réparer, des matériaux de réparation et de l’environnement dans lequel ils vont être mis en œuvre, mais aussi une ... [more ▼]La réparation des bétons nécessite non seulement une bonne connaissance du support à réparer, des matériaux de réparation et de l’environnement dans lequel ils vont être mis en œuvre, mais aussi une compréhension des mécanismes à la base de l’adhésion. Les compatibilités dimensionnelle, électrochimique, chimique et porosimétrique (perméabilité) sont les clés de la réussite et de la durabilité de la réparation. Sur la base de l’analyse du patrimoine en béton armé et des stratégies d’intervention possible, l’accent a été placé dans la première partie sur l’étude des effets et des causes des principaux défauts de surface observés. Une fois la condition du béton en place adéquatement évaluée (Partie 1), la préparation de la surface avant réparation, sa propreté ou encore sa rugosité sont des conditions essentielles au développement de l’adhérence et de l’accrochage du produit de réparation, garantissant ainsi la durabilité de l’intervention. [less ▲]Detailed reference viewed: 19 (1 ULg) Prognostic relevance of epilepsy at presentation in glioblastoma patients.Berendsen, Sharon; Varkila, Meri; Kroonen, Jerome et alin Neuro-oncology (2016)BACKGROUND: Epileptogenic glioblastomas are thought to convey a favorable prognosis, either due to early diagnosis or potential antitumor effects of antiepileptic drugs. We investigated the relationship ... [more ▼]BACKGROUND: Epileptogenic glioblastomas are thought to convey a favorable prognosis, either due to early diagnosis or potential antitumor effects of antiepileptic drugs. We investigated the relationship between survival and epilepsy at presentation, early diagnosis, and antiepileptic drug therapy in glioblastoma patients. METHODS: Multivariable Cox regression was applied to survival data of 647 consecutive patients diagnosed with de novo glioblastoma between 2005 and 2013 in order to investigate the association between epilepsy and survival in glioblastoma patients. In addition, we quantified the association between survival and valproic acid (VPA) treatment. RESULTS: Epilepsy correlated positively with survival (HR: 0.75 (95% CI: 0.61-0.92), P < .01). This effect is independent of age, sex, performance status, type of surgery, adjuvant therapy, tumor location, and tumor volume, suggesting that this positive correlation cannot be attributed solely to early diagnosis. For patients who presented with epilepsy, the use of the antiepileptic drug VPA did not associate with survival when compared with patients who did not receive VPA treatment. CONCLUSION: Epilepsy is an independent prognostic factor for longer survival in glioblastoma patients. This prognostic effect is not solely explained by early diagnosis, and survival is not associated with VPA treatment. [less ▲]Detailed reference viewed: 21 (5 ULg) Comparison of Moving Boundary and Finite-Volume Heat Exchanger Models in the Modelica LanguageDesideri, Adriano ; Dechesne, Bertrand ; Wronski, Jorrit et alin energies (2016)When modeling low capacity energy systems, such as a small size (5–150kWel) organic Rankine cycle unit, the governing dynamics are mainly concentrated in the heat exchangers. As a consequence, the ... [more ▼]When modeling low capacity energy systems, such as a small size (5–150kWel) organic Rankine cycle unit, the governing dynamics are mainly concentrated in the heat exchangers. As a consequence, the accuracy and simulation speed of the higher level system model mainly depend on the heat exchanger model formulation. In particular, the modeling of thermo-flow systems characterized by evaporation or condensation requires heat exchanger models capable of handling phase transitions. To this aim, the finite volume (FV) and the moving boundary (MB) approaches are the most widely used. The two models are developed and included in the open-source ThermoCycle Modelica library. In this contribution, a comparison between the two approaches is presented. An integrity and accuracy test is designed to evaluate the performance of the FV and MB models during transient conditions. In order to analyze how the two modeling approaches perform when integrated at a system level, two organic Rankine cycle (ORC) system models are built using the FV and the MB evaporator model, and their responses are compared against experimental data collected on an 11kWel ORC power unit. Additionally, the effect of the void fraction value in the MB evaporator model and of the number of control volumes (CVs) in the FV one is investigated. The results allow drawing general guidelines for the development of heat exchanger dynamic models involving two-phase flows. [less ▲]Detailed reference viewed: 29 (7 ULg) Distribution of heavy and clay minerals in coastal sediment of jijel, East of Algeria: indicators of sediment sources and transport and deposition environmentsKERMANI, S.; BOUTIBA, M.; BOUTALEB, A. et alin Arabian Journal of Geosciences (2016)Detailed reference viewed: 113 (30 ULg) Antes del "monstruo" de Rojas: Las conversiones de José Martín RecuerdaFrancois, Jeromine in Dicenda (2016), 35Detailed reference viewed: 22 (0 ULg) Non-ovarian aromatization is required to activate female sexual motivation in testosterone-treated ovariectomized quailde Bournonville, Catherine; Balthazart, Jacques ; Ball, Gregory et alin Hormones and Behavior (2016), 83Detailed reference viewed: 24 (3 ULg) Prevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: A Randomized Controlled Trial.Muysoms, Filip E.; DETRY, Olivier ; Vierendeels, Tijl et alin Annals of surgery (2016), 263(4), 638-645BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high ... [more ▼]BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high risk of incisional hernia. METHODS: A multicenter randomized trial was conducted on patients undergoing elective abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133). In the study group, retromuscular mesh-augmented reinforcement was performed with a large-pore polypropylene mesh (Ultrapro, width 7.5 cm). The primary endpoint was the incidence of incisional hernias at 2-year follow-up. RESULTS: Between February 2009 and January 2013, 120 patients were recruited at 8 Belgian centers. Patients' characteristics at baseline were similar between groups. Operative and postoperative characteristics showed no difference in morbidity or mortality. The cumulative incidence of incisional hernias at 2-year follow-up after conventional closure was 28% (95% confidence interval [CI], 17%-41%) versus 0% (95% CI, 0%-6%) after mesh-augmented reinforcement (P < 0.0001; Fisher exact test). The estimated "freedom of incisional hernia" curves (Kaplan-Meier estimate) were significantly different across study arms (chi = 19.5, P < 0.0001; Mantel-Cox test). No adverse effect related to mesh-augmented reinforcement was observed, apart from an increased mean time to close the abdominal wall for mesh-augmented reinforcement compared with the control group: 46 minutes (SD, 18.6) versus 30 minutes (SD, 18.5), respectively (P < 0.001; Mann-Whitney U test). CONCLUSIONS: Prophylactic retromuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic aneurysm is safe and effectively prevents the development of incisional hernia during 2 years, with an additional mean operative time of 16 minutes. [less ▲]Detailed reference viewed: 15 (4 ULg) Gender effect on the scapular 3D posture and kinematic in healthy subjectsSchwartz, Cédric ; Croisier, Jean-Louis ; Rigaux, Elise et alin Clinical Physiology and Functional Imaging (2016)Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However ... [more ▼]Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However the literature reports, for the shoulder, differences in the range of motion between genders. The specific influence of gender on the scapula-thoracic kinematics has not been studied yet. The dominant shoulder of two populations of men and women composed of 11 subjects each were evaluated in three dimensions for three distinct motions: flexion in the sagittal plane, abduction in the frontal plane and gleno-humeral internal/external rotation with the arm abducted at 90°. Posture, kinematics and range of motion were studied separately. For flexion and abduction and with regard to the scapular kinematic, external rotation were significantly larger for women than men. The differences were of at least 5° at 120° of humeral elevation. Upward rotations were identical. Women also showed larger average active humero-thoracic range of motion. The mean differences were of 13°, 7°, 12° and 5° for abduction, flexion, internal rotation and external rotation, respectively. No difference was observed between the scapular resting positions of both populations. The observed differences concerning both the scapular and humeral patterns would indicate that the shoulder behavior of men and women should not be expected to be similar. [less ▲]Detailed reference viewed: 114 (34 ULg) Efficacy and safety of hyaluronic acid in the management of osteoarthritis : Evidence from real-life setting trials and surveys.Maheu, E.; Rannou, F.; Reginster, Jean-Yves in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 28-33The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee ... [more ▼]The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee osteoarthritis (OA) as second-line treatment in patients who remain symptomatic despite use of non-steroidal anti-inflammatory drugs (NSAIDs). This recommendation is based upon accumulating evidence that IA HA provides a significant benefit in knee OA. There is good evidence that IA HA injections reduce pain and increase function in knee OA, and the benefits are long-lasting as compared with IA corticosteroids. Evidence from real-life studies of repeat courses of IA HA demonstrates an improvement in pain or function lasting up to 40 months (12 months after the last injection cycle), a reduction in use of concomitant analgesia by up to 50%, and suggests that there may be a delay in the need for total knee replacement (TKR) of around 2 years. The clinical benefit of IA HA on knee OA may be 2-fold: (i) mechanical viscosupplementation of the joint (allowing lubrication and shock absorption) and (ii) the re-establishment of joint homeostasis through induction of endogenous HA production, which continues long after the exogenous injection has left the joint.The magnitude of the clinical effect may be different for different HA products, but this has not been proven so far and requires further investigation. IA HA injections are generally considered to be safe,although a slightly higher number of cases of local reactions and post-injection non-septic arthritis has been reported with high molecular weight cross-linked HAs. The use of IA HA in knee OA patients with mild–moderate disease, and for more severe patients wishing to delay TKR surgery,is recommended by the ESCEO taskforce. Further investigation into the OA patient types most likely to benefit from IA HA is warranted. Viscosupplementation with IA HA is a safe and effective component of the multi-modal management of knee OA. [less ▲]Detailed reference viewed: 19 (6 ULg) Des voisins encombrants, l’édition belge entre France et Pays-BasHabrand, Tanguy in Revue des Livres pour Enfants (2016) Chemical composition of essential oils and floral waters of Mentha longifolia (L.) Huds. from SenegalDiop, Serigne Mbacké; Guèye, Momar Talla; Ndiaye, Ibrahima et alin American Journal of Essential Oils and Natural Products (2016), 4(1), 46-49Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively ... [more ▼]Essential oils of Mentha longifolia from Senegal were extracted from fresh plants and dried plants in the shade for 7 days. The yields were of 0.39 and 0.32% in the fresh and dried plants respectively. Analysis of the essential oils, floral waters and the assay of pulegone were carried out by GC/FID and GC/MS. The major compounds identified in the oils were pulegone (52.0 and 42.4%), menthone (14.3 and 21.2%), 1, 8-cineole (13.1 and 11.4%) and isomenthone (9.0 and 13.2%) in the fresh and dried plants, respectively. Analyses revealed that floral waters were also characterized by the same major compounds as essential oils but at different rates. In these floral waters, pulegone constituted 60.2 and 47.0%, 1,8- cineole 7.9 and 19.6%, isomenthone 7.2 and 10.7%, menthone 6.4 and 9.2%, chrysanthenone 6.4 and 3.2% and α-terpineol 3.0 and 2.7% in the fresh and dried plants, respectively. The assay results of pulegone, a hepatotoxic compound, have shown very high levels (444.6 and 393.3mg/g) in both fresh and dried plants. [less ▲]Detailed reference viewed: 27 (1 ULg) Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2).Butler, Georgina S.; Connor, Andrea R.; Sounni, Nor Eddine et alin Matrix Biology (2016)Members of the CCN family of matricellular proteins are cytokines linking cells to the extracellular matrix. We report that CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14 (membrane-type 1 ... [more ▼]Members of the CCN family of matricellular proteins are cytokines linking cells to the extracellular matrix. We report that CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14 (membrane-type 1-matrix metalloproteinase, MT1-MMP) that we identified using MMP14 "inactive catalytic domain capture" (ICDC) as a yeast two-hybrid protease substrate trapping platform in parallel with degradomics mass spectrometry screens for MMP14 substrates. CCN3 and CCN5, previously unknown substrates of MMPs, were biochemically validated as substrates of MMP14 and other MMPs in vitro-CCN5 was processed in the variable region by MMP14 and MMP2, as well as by MMP1, 3, 7, 8, 9 and 15. CCN1, 2 and 3 are proangiogenic factors yet we found novel opposing activity of CCN5 that was potently antiangiogenic in an aortic ring vessel outgrowth model. MMP14, a known regulator of angiogenesis, cleaved CCN5 and abrogated the angiostatic activity. CCN3 was also processed in the variable region by MMP14 and MMP2, and by MMP1, 8 and 9. In addition to the previously reported cleavages of CCN1 and CCN2 by several MMPs we found that MMPs 8, 9, and 1 process CCN1, and MMP8 and MMP9 also process CCN2. Thus, our study reveals additional and pervasive family-wide processing of CCN matricellular proteins/cytokines by MMPs. Furthermore, CCN5 cleavage by proangiogenic MMPs results in removal of an angiogenic brake held by CCN5. This highlights the importance of thorough dissection of MMP substrates that is needed to reveal higher-level control mechanisms beyond type IV collagen and other extracellular matrix protein remodelling in angiogenesis. SUMMARY: We find CCN family member cleavage by MMPs is more pervasive than previously reported and includes CCN3 (Nov) and CCN5 (WISP2). CCN5 is a novel antiangiogenic factor, whose function is abrogated by proangiogenic MMP cleavage. By processing CCN proteins, MMPs regulate cell responses angiogenesis in connective tissues. [less ▲]Detailed reference viewed: 8 (0 ULg) Effects of 10Hz and 20Hz transcranial alternating current stimulation on automatic motor controlCappon, Davide; D'Ostilio, Kevin ; Garraux, Gaëtan et alin Brain Stimulation (2016)Background: Automatic motor inhibition is an important and adaptive process through which an activated motor plan is suppressed if the movement is not intended to be executed. Neuronal networks are ... [more ▼]Background: Automatic motor inhibition is an important and adaptive process through which an activated motor plan is suppressed if the movement is not intended to be executed. Neuronal networks are characterized by oscillatory activity. In the brain, a large variety of rhythms have been described that differ in their frequency, origin and reactivity to changes in task demands. Recent studies have demonstrated that active cortical networks are susceptible to weak sinusoidal perturbations of exogenous electric fields. Objective/Hypothesis: The aim of this study was to investigate the frequency-specific effect of transcranial alternate current stimulation (tACS) over the automatic control of movement in healthy volunteers. We hypothesized that applying two different tACS frequencies during a visuo-motor task would result in different behavioural effects and in diverse modulation of cortical excitability. Methods: In this study we used tACS to interact non-invasively with the ongoing task-related oscillatory activity. Stimulation was delivered at alpha (10 Hz) and beta (20 Hz) frequency over the supplementary motor area and the primary motor cortex (SMA-M1) connections, which are part of the BG-cortical motor loop, during the execution of the subliminal masked prime task. We measured the effects on task performance and on motor cortex corticospinal excitability by means of motor evoked potentials (MEPs) evoked by transcranial magnetic stimulation (TMS). Results: Results indicate a specific effect of 10 and 20-Hz tACS on functional inhibition in the SMA-M1 circuit. Behaviorally there is an interference in task-related automatic inhibition: 10 Hz tACS reduced the automatic inhibition. In contrast 20 Hz tACS increased the automatic inhibition. At a neurophysiological level there is a modulation in excitability of M1: 20 Hz tACS reduced MEP amplitudes, whereas there was no change after 10 Hz tACS. Conclusion(s): The current study provides novel evidence that automatic mechanisms of motor behaviour can be modulated by imposing synchronized electrical oscillatory activity upon motor cortical regions. Our study has important implications for cognitive neuroscience studies suggesting that the use tACS might offer the possibility to demonstrate a causal link between endogenous brain oscillations, specific exogenous alternate current frequencies and specific cognitive processes. [less ▲]Detailed reference viewed: 81 (1 ULg) Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure.van Hemmen, J.; Saris, I. M. J.; Cohen-Kettenis, P. T. et alin Cerebral cortex (New York, N.Y. : 1991) (2016)Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the ... [more ▼]Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extended WM regions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation of WM microstructure, although sex chromosome genes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role. [less ▲]Detailed reference viewed: 13 (0 ULg) VALIDATION OF THE FRENCH VERSION OF THE PARENTING STRESS INDEX–SHORT FORM (FOURTH EDITION)Toucheque, Malorie ; Etienne, Anne-Marie ; Stassart, Céline et alin Journal of Community Psychology (2016), 44(4), 419-425Introduction: The Parenting Stress Index (PSI) is widely used to measure stress related to the demands of parenthood. Unfortunately, no French adaptation and validation of the PSI Short Form (Fourth ... [more ▼]Introduction: The Parenting Stress Index (PSI) is widely used to measure stress related to the demands of parenthood. Unfortunately, no French adaptation and validation of the PSI Short Form (Fourth Edition) had yet been published. This study examine the factor structure and the psychometric properties of the French translation of the PSI-4-SF. Method: Sample consists of 210 parents of children aged 5 to 12 years old. Factor structure of the PSI-4-SF was investigated using confirmatory factor analysis (CFA). Three models were tested, with one, two and three dimensions. Internal consistency reliability and validity were also examined. Results: CFA showed that the original three-factor solution most closely approximated our data despite the imperfection of the model fit indices. Results also indicated a good internal consistency reliability and validity. Conclusion: The French version of the PSI-4-SF shows promise as a valuable instrument for assessing parenting stress in the French-speaking population. [less ▲]Detailed reference viewed: 39 (8 ULg) Detecting urban road network accessibility problems using taxi GPS dataCui, JianXun; Liu, Feng; Janssens, Davy et alin Journal of Transport Geography (2016), 51Urban population growth and economic development have led to the creation of new communities, jobs and services at places where the existing road network might not cover or efficiently handle traffic ... [more ▼]Urban population growth and economic development have led to the creation of new communities, jobs and services at places where the existing road network might not cover or efficiently handle traffic. This generates isolated pockets of areas which are difficult to reach through the transport system. To address this accessibility problem, we have developed a novel approach to systematically examine the current urban land use and road network conditions as well as to identify poorly connected regions, using GPS data collected from taxis. This method is composed of four major steps. First, city-wide passenger travel demand patterns and travel times are modeled based on GPS trajectories. Upon this model, high density residential regions are then identified, and measures to assess accessibility of each of these places are developed. Next, the regions with the lowest level of accessibility among all the residential areas are detected, and finally the detected regions are further examined and specific transport situations are analyzed. By applying the proposed method to the Chinese city of Harbin, we have identified 20 regions that have the lowest level of accessibility by car among all the identified residential areas. A serious reachability problem to petrol stations has also been discovered, in which drivers from 92.6% of the residential areas have to travel longer than 30 min to refill their cars. Furthermore, the comparison against a baseline model reveals the capacity of the derived measures in accounting for the actual travel routes under divergent traffic conditions. The experimental results demonstrate the potential and effectiveness of the proposed method in detecting car-based accessibility problems, contributing towards the development of urban road networks into a system that has better reachability and more reduced inequity. [less ▲]Detailed reference viewed: 23 (1 ULg) [18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinomaWITHOFS, Nadia ; Martinive, Philippe ; VANDERICK, Jean et alin European journal of nuclear medicine and molecular imaging (2016)PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal ... [more ▼]PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use. [less ▲]Detailed reference viewed: 39 (9 ULg) Biosynthesis, Chemical Structure, and Structure-Activity Relationship of Orfamide Lipopeptides Produced by Pseudomonas protegens and Related SpeciesMa, Zongwang; Geudens, Niels; Kieu, Nam P. et alin Frontiers in Microbiology (2016), 7Detailed reference viewed: 6 (0 ULg) Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signsBaise, Etienne ; Habyarimana, Jean ; Amory, Hélène et alin Equine Veterinary Journal (2016)Detailed reference viewed: 82 (35 ULg) Improving Farmers’ Profitability, Soil and Water Conservation through an Adapted Tillage Technique: Experiences from the Cultivation of Potatoes in Bamiléké’s Hills, CameroonDjoukeng, Henri Grisseur ; Brostaux, Yves ; Tankou, Christopher Mubeteneh et alin International Journal of Agriculture Innovations and Research (2016), 4(4), 708-716On farms situated on slopes, such as those in the Western Highlands of Cameroon, the implementation of soil and water conservation techniques remains a major concern. The land preparation methods commonly ... [more ▼]On farms situated on slopes, such as those in the Western Highlands of Cameroon, the implementation of soil and water conservation techniques remains a major concern. The land preparation methods commonly practiced in the Western Highlands agro-ecological zone of Cameroon are ridging along the steepest slopes (RASS) and the flatbed (FB). Field observations showed FB and RASS promote erosion by runoff, thereby compromising some agriculture functions (environmental function, production function and even social function). In order to ensure soil stability and maintain good water quality for rivers, a new land preparation method, tied ridging (TR), was tested. Erosion by runoff tests were conducted with four blocks of three plots on each of the most commonly exploited slopes, namely 11% and 29% gradient. With the main crop in the area (potato, Solanum tuberosum L.), the performance of RASS, FB, and TR were compared during crop years 2013 and 2014. The water runoff and sediments were collected per plot and per block after every rainfall. The results showed a significant difference between the FB or RASS and TR in terms of soil loss (Fmin(2, 2) = 322.7, p = 0.003), yields (F(2, 2) = 287.7, p = 0.003), and runoff water (Fmin(2, 12) = 2.4x106, p < 0.001). The TR technique generated a 7% increase in seedlings density, a 41% increase in the workforce, and an 81% and 100% increase in yields compared to FB in 11% and 29% slopes, respectively. The TR increased farmer’s profitability by 686 US$.ha-1 and 1420 US$.ha-1 over RASS in 11% and 29% slopes, respectively. The TR showed undeniable advantages: for the producer, the stress of additional work was offset by the gain in yields while creating additional job opportunities and improving the conservation of soil and water. Although the technique has several advantages, the provision of financial means for its implementation could be a negative point. Twelve farmers were involved in the experiment. The test results convinced the participants and other curious farmers who adopted the technology during the second experiment. [less ▲]Detailed reference viewed: 40 (13 ULg) Risk assessment of soil compaction in the Walloon region in BelgiumD'Or, Dimitri; Destain, Marie-France in Mathematical Geosciences (2016)It is well known that soil compaction affects root growth and disrupts the activity of soil microfauna and microorganisms, resulting in yield loss. With the more intensive use of heavy machines in ... [more ▼]It is well known that soil compaction affects root growth and disrupts the activity of soil microfauna and microorganisms, resulting in yield loss. With the more intensive use of heavy machines in agriculture and forestry, the risk of soil compaction is increasing. In this study, precompression stress (Pc) was chosen as an indicator of the susceptibility of soils to compaction and was calculated using pedotransfer functions (PTFs). PTFs involve eight variables related to the hydraulic and mechanical behaviour of soils: organic matter content; bulk density; air capacity; available water capacity; non-plant available water capacity; saturated hydraulic conductivity; cohesion; and angle of internal friction. Combining these PTFs with geostatistics and Monte Carlo simulations, Pc maps were produced at the regional scale for Wallonia in Belgium, accompanied by uncertainty quantification maps. These maps were then used to produce compaction risk maps based on common scenarios. The results showed that the modal Pc map was coherent with the spatial distribution of the main variables, namely soil texture and organic matter content. The risk maps enabled areas with a compaction risk in both agricultural and forestry contexts to be identified. These maps could be useful in drawing up soil protection measures and policies. [less ▲]Detailed reference viewed: 38 (11 ULg) Growth hormone releasing hormone excess and blockade in X-LAG syndrome.Daly, Adrian Francis ; Lysy, Philippe; Defilles, Celine et alin Endocrine-related cancer (2016)X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and ... [more ▼]X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GH-releasing hormone (GHRH) levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(D-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. [less ▲]Detailed reference viewed: 36 (16 ULg) Electrophoretic deposition of hydroxyapatite and hydroxyapatite– alginate on rapid prototyped 3D Ti6Al4V scaffoldsOzhukil Kollath, Vinayaraj; Chen, Qiang; Mullens, Steven et alin Journal of Materials Science (2016), 51The advantage of using bioceramic particles coated on porous three-dimensional structures is still unexplored in the purpose of improving the osteoinduction of hybrid metallic scaffold implants in vivo ... [more ▼]The advantage of using bioceramic particles coated on porous three-dimensional structures is still unexplored in the purpose of improving the osteoinduction of hybrid metallic scaffold implants in vivo. In this study, we evaluate electrophoretic deposition (EPD) to coat porous Ti6Al4V scaffolds with hydroxyapatite (HA). Scaffolds were shaped in different open structures with a horizontal shift in fiber stacking. They were produced using three-dimensional fiber deposition method and were coated by EPD with HA powder (d10 = 1.7, d50 = 5.7 and d90 = 18 lm) suspended in ethanol or butanol at different concentration, DC voltage, and time. A composite HA–alginate was also used to coat the scaffolds. Alginate was used as a binder, and the coating properties (homogeneity, thickness, cracks, continuity, etc.) were compared to coatings obtained from pure HA suspensions. Voltage and time of deposition effects were studied between 10 and 140 V and 10 and 120 s, respectively. Coating thickness and density with respect to the depth of the porous structure were studied by observing cross sections using scanning electron microscopy and image processing analysis. HA–alginate combination resulted in a homogeneous and deeper dense layer of HA. This work also points to the characteristics of HA–alginate composite as a superior alternative to pure HA coating which needs an appropriate thermal treatment for adequate substrate adhesion. [less ▲]Detailed reference viewed: 32 (6 ULg) The thyroid gland and thyroid hormones in sheepshead minnow (Cyprinodon variegatus) during early development and metamorphosisSchnitzler, Joseph ; Klaren, Peter; Mariavelle, Emeline et alin Fish Physiology and Biochemistry (2016), 42(2), 607-616The sheepshead minnow is widely used in ecotoxicological studies that only recently have begun to focus on disruption of the thyroid axis by xenobiotics and endocrine disrupting compounds. However ... [more ▼]The sheepshead minnow is widely used in ecotoxicological studies that only recently have begun to focus on disruption of the thyroid axis by xenobiotics and endocrine disrupting compounds. However, reference levels of the thyroid prohormone thyroxine (T4) and biologically active hormone 3,5,30-triiodothyronine (T3) and their developmental patterns are unknown. This study set out to describe the ontogeny and morphology of the thyroid gland in sheepshead minnow, and to correlate these with whole-body concentrations of thyroid hormones during early development and metamorphosis. Eggs were collected by natural spawning in our laboratory. T4 and T3 were extracted from embryos, larvae and juveniles and an enzyme-linked immunoassay was used to measure whole-body hormone levels. Length and body mass, hatching success, gross morphology, thyroid hormone levels and histology were measured. The onset of metamorphosis at 12-day post-hatching coincided with surges in whole-body T4 and T3 concentrations. Thyroid follicles were first observed in pre-metamorphic larvae at hatching and were detected exclusively in the subpharyngeal region, surrounding the ventral aorta. Follicle size and thyrocyte epithelial cell heights varied during development, indicating fluctuations in thyroid hormone synthesis activity. The increase in the whole-body T3/T4 ratio was indicative of an increase in outer ring deiodination activity. This study establishes a baseline for thyroid hormones in sheepshead minnows, which will be useful for the understanding of thyroid hormone functions and in future studies of thyroid toxicants in this species. [less ▲]Detailed reference viewed: 42 (20 ULg) Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study GroupLübbert, Michael; Suciu, Stefan; Hagemeijer, Anne et alin Annals of Hematology (2016), 95In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal ... [more ▼]In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal monosomies (MK2+) within a complex karyotype (Lübbert et al., Haematologica 97:393-401, 2012). We now analyzed 206 myelodysplastic syndrome (MDS) patients (88 % of 233 patients randomized in the EORTC/GMDSSG phase III trial 06011, 61 of them with RAEBt, i.e. AML by WHO) with cytogenetics informative for MK status.. Endpoints are the following: complete/partial (CR/PR) and overall response rate (ORR) and progression-free (PFS) and overall survival (OS). Cytogenetic subgroups are the following: 63 cytogenetically normal (CN) patients, 143 with cytogenetic abnormalities, 73 of them MKnegative (MK−), and 70 MK-positive (MK+). These MK+ patients could be divided into 17 with a single autosomal monosomy (MK1) and 53 with at least two monosomies (MK2+). ORR with DAC in CN patients: 36.1 %, in MK−patients: 16.7 %, in MK+ patients: 43.6 % (MK1: 44.4 %, MK2+ 43.3 %). PFS was prolonged by DAC compared to best supportive care (BSC) in the CN (hazard ratio (HR) 0.55, 99 % confidence interval (CI), 0.26; 1.15, p=0.03) and MK2+ (HR 0.50; 99%CI, 0.23; 1.06, p=0.016) but not in the MK−, MK+, and MK1 subgroups. OS was not improved by DAC in any subgroup. In conclusion, we demonstrate for the first time in a randomized phase III trial that high-risk MDS patients with complex karyotypes harboring two or more autosomal monosomies attain encouraging responses and have improved PFS with DAC treatment compared to BSC. [less ▲]Detailed reference viewed: 10 (1 ULg) Compte-rendu de Pierre-Jean Renaudie, Husserl et les catégories. Langage, pensée et perception, Paris, Vrin, 2015Leclercq, Bruno in Philosophiques (2016), 43(1), 149-153Detailed reference viewed: 26 (0 ULg) PrésentationGauvry, Charlotte ; Leclercq, Bruno in Bulletin d'Analyse Phénoménologique (2016)Detailed reference viewed: 9 (0 ULg) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.Ponikowski, Piotr; Voors, Adriaan A.; Anker, Stefan D. et alin European Heart Journal (2016)Detailed reference viewed: 9 (2 ULg)