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See detailDerrière les mots du politique. Le-pire-est-à-venir, un marqueur temporel particulier dans le discours politique en Belgique
Piet, Grégory ULg

in Mots. Les Langages du Politique (2013), 103

Que peut-on apprendre des arguments en science politique quant à leur rôle dans les discours ? S’inscrivant dans la suite des travaux sur les bifurcations et reposant sur une analyse des arguments et des ... [more ▼]

Que peut-on apprendre des arguments en science politique quant à leur rôle dans les discours ? S’inscrivant dans la suite des travaux sur les bifurcations et reposant sur une analyse des arguments et des discours politiques belges relatifs au climat, cet article interroge la fonctionnalité du marqueur le-pire-est-à-venir. Ce dernier, riche d’enseignement, s’apparente à la fois : 1) à un marqueur temporel particulier marquant le changement, 2) à un révélateur de figures politiques et 3) à un marqueur hybride dans l’énonciation des régimes de l’avenir. [less ▲]

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See detailRefractory hypercalcemia and ectopic calcitonin secretion in a malignant pancreatic neuroendocrine tumor: hypocalcemic effects on cinacalcet
VALDES SOCIN, Hernan Gonzalo ULg; rubio almanza, Matilde; LOLY, Jean-Philippe ULg et al

in Acta Clinica Belgica (2013), 68(6), 42

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

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See detailOn the mechanism of elasto-inertial turbulence
Dubief, Yves; Terrapon, Vincent ULg; Soria, Julio

in Physics of Fluids (2013), 25(110817), 1-16

Elasto-inertial turbulence (EIT) is a new state of turbulence found in inertial flows with polymer additives. The dynamics of turbulence generated and controlled by such additives is investigated from the ... [more ▼]

Elasto-inertial turbulence (EIT) is a new state of turbulence found in inertial flows with polymer additives. The dynamics of turbulence generated and controlled by such additives is investigated from the perspective of the coupling between polymer dynamics and flow structures. Direct numerical simulations of channel flow with Reynolds numbers ranging from 1000 to 6000 (based on the bulk and the channel height) are used to study the formation and dynamics of elastic instabilities and their effects on the flow. The flow topology of EIT is found to differ significantly from Newtonian wall-turbulence. Structures identified by positive (rotational flow topology) and negative (extensional/compressional flow topology) second invariant Qa isosurfaces of the velocity gradient are cylindrical and aligned in the spanwise direction. Polymers are significantly stretched in sheet-like regions that extend in the streamwise direction with a small upward tilt. The Qa cylindrical structures emerge from the sheets of high polymer extension, in a mechanism of energy transfer from the fluctuations of the polymer stress work to the turbulent kinetic energy. At subcritical Reynolds numbers, EIT is observed at modest Weissenberg number (Wi, ratio polymer relaxation time to viscous time scale). For supercritical Reynolds numbers, flows approach EIT at large Wi. EIT provides new insights on the nature of the asymptotic state of polymer drag reduction (maximum drag reduction), and explains the phenomenon of early turbulence, or onset of turbulence at lower Reynolds numbers than for Newtonian flows observed in some polymeric flows. [less ▲]

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See detailOvergenerality Memory Style for Past and Future Events and Emotions Related in Bipolar Disorder. What are the Links with Problem Solving and Interpersonal Relationships?
Boulanger, Marie ULg; Lejeune, Aurélie; Blairy, Sylvie ULg

in Psychiatry Research (2013), 210(3), 863-870

This study investigated patients with Bipolar Disorder’s abilities to generate specific past and future events in response to positive and negative cues words as well as emotional intensity related to ... [more ▼]

This study investigated patients with Bipolar Disorder’s abilities to generate specific past and future events in response to positive and negative cues words as well as emotional intensity related to these ones. The relationships between the number of generated specific events cognitive functioning, interpersonal problems and the ability to problem solving were investigated. Nineteen BD and nineteen healthy controls completed a French version of the AMT to evaluate the past and future events recall, in function of their valence, and emotions related. Furthermore, they completed the Optional Thinking Test, the Inventory of Interpersonal Problems and the neuropsychological measures. Compared to healthy controls, BD recollected (1) fewer specific past negative events and (2) fewer future specific positive and negative events furthermore, (3) they felt more emotional intensity related to future events. These results were explained in the light of theoretical models. Finally, specific past memories deficits in BD were linked with issues in problem solving but not with levels of distress arising from interpersonal problems. In view of AM functions in everyday life, all types of deficits should be taken into consideration, and AM remediation envisaged. [less ▲]

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See detailEsterification of vertebrate like steroids in molluscs: A target of endocrine disruptors?
Giusti, Arnaud ULg; Joaquim-Justo, Célia ULg

in Comparative Biochemistry and Physiology. C : Comparative Pharmacology and Toxicology (2013), 158(4), 187-198

Alterations of the reproductive organs of gastropod molluscs exposed to pollutants have been reported in natural populations for more than 40 years. In some cases these impacts have been linked to ... [more ▼]

Alterations of the reproductive organs of gastropod molluscs exposed to pollutants have been reported in natural populations for more than 40 years. In some cases these impacts have been linked to exposure to endocrine disrupting chemicals (EDCs), which are known to induce adverse impacts on vertebrates, mainly by direct binding to steroid receptors or by altering hormone synthesis. Investigations on the mechanisms of action of endocrine disruptors in molluscs show that EDCs induce modifications of endogenous titres of androgens (e.g., testosterone, androstenedione) and oestrogens (e.g., 17ß-oestradiol). Alterations of the activity of enzymes related to steroid metabolism (i.e., cytochrome P450 aromatase, acyltransferases) are also often observed. In bivalves and gastropods, fatty acid esterification of steroids might constitute the major regulation of androgen and oestrogen homeostasis. The present review indicates that metabolism of steroid hormones to fatty acid esters might be a target of synthetic EDCs. Alterations of this process would impact the concentrations of free, potentially bioactive, form of steroids. [less ▲]

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See detailHypovitaminose D du patient brûlé : une équation à plusieurs inconnues.
ROUSSEAU, Anne-Françoise ULg; LEDOUX, Didier ULg; DAMAS, Pierre ULg et al

in Revue Médicale de Liège (2013), 68(11), 574-578

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See detailSocialisation et intérêts politiques : nouvelles contributions empiriques
Fournier, Bernard; Grandjean, Geoffrey ULg

in Politique et Sociétés (2013), 32(2),

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See detailDesign and evaluation of a semantic enrichment process for bibliographic databases
Lacasta, Javier; Nogueras-Iso, Javier; Falquet, Gilles et al

in Data & Knowledge Engineering (2013), 88

The limited semantics of thesauri and similar knowledge models hinder the searching and browsing possibilities of the bibliographic databases classified with this type of resources. This work proposes an ... [more ▼]

The limited semantics of thesauri and similar knowledge models hinder the searching and browsing possibilities of the bibliographic databases classified with this type of resources. This work proposes an automatic process to convert a knowledge model into a domain ontology through the alignment with DOLCE, an upper level ontology. This process is facilitated by an intermediary alignment with Wordnet, a lexical model. The process has been tested with the thesauri and bibliographic databases of Urbamet and the European Urban Knowledge Network. The Urbamet model has been used to create an atlas of urban related resources with advanced search capabilities. [less ▲]

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See detailComparison of insulin degludec with insulin glargine in insulin-naive subjects with Type 2 diabetes: a 2-year randomized, treat-to-target trial.
Begin once trial investigators; RADERMECKER, Régis ULg

in Diabetic Medicine : A Journal of the British Diabetic Association (2013)

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See detailApplication of an innovative design space optimization strategy to thedevelopment of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines
Mbinze Kindenge, Jérémie ULg; Dispas, Amandine ULg; Lebrun, Pierre ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2013), 85

The poor quality of medicines is a crucial problem of public health. Therefore, it is important to haveanalytical tools to attend decisions of the legal authorities while combating this offense. In this ... [more ▼]

The poor quality of medicines is a crucial problem of public health. Therefore, it is important to haveanalytical tools to attend decisions of the legal authorities while combating this offense. In this context,the main objective of this study was to develop generic methods able to trace, screen and determineseveral antibiotics and common associated molecules by mean of liquid chromatographic techniques.For that purpose, an innovative Design Space optimization strategy was applied, targeting 16 antibioticsand 3 beta-lactamase inhibitors. The robustness of the developed method allowed using its use in anenvironment where operational factors such as temperature are not easy to control and eased its trans-fer to Ultra High Performance Liquid Chromatography. To demonstrate its ability to quantify the targetedmolecules, the developed and transferred method was fully validated for two active ingredients com-monly used in association, sulbactam and ceftriaxone, using the accuracy profile as decision tool. Basedon this successful step, the method was then used for the quantitative determination of these two activeingredients in three pharmaceutical brands marketed in the Democratic Republic of Congo. Two out ofthe three pharmaceutical products did not comply with the specifications [less ▲]

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See detailStrategjia e Turqisë përballë shteteve të Ballkanit Perëndimor
Lika, Liridon ULg

in Revista Shkencore Ndërkombëtare Diskutime (2013), Deuxième année(Numéro 8), 62-71

Abstract: Since coming to power of the Justice and Development Party (Adalet ve Kalkinma Partisi, AKP) in 2002, Turkey, like other emerging powers, does not hesitate to pursue a policy based on ... [more ▼]

Abstract: Since coming to power of the Justice and Development Party (Adalet ve Kalkinma Partisi, AKP) in 2002, Turkey, like other emerging powers, does not hesitate to pursue a policy based on diversification of its external relations in order to play a greater role on the international scene. The Turkish government has adopted a foreign policy so called "zero problems" with neighboring countries including the Western Balkans. Through such a policy, the Turkish authorities are making efforts to regain influence in this area, which for five centuries was part of the Ottoman Empire. However, current circumstances in the Balkans are totally different compared to those of a century ago. Therefore, proactive ambitions of Turkish foreign policy for a classic domination of the region appear to be inconsistent with the time. [less ▲]

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See detailUnsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages
L'Homme, Laurent ULg; Esser, Nathalie ULg; Riva, Laura ULg et al

in Journal of Lipid Research (2013), 54

The NLRP3 inflammasome is involved in many obesity-associated diseases such as type 2 diabetes, atherosclerosis and gouty arthritis through its ability to induce IL-1β release. The molecular link between ... [more ▼]

The NLRP3 inflammasome is involved in many obesity-associated diseases such as type 2 diabetes, atherosclerosis and gouty arthritis through its ability to induce IL-1β release. The molecular link between obesity and inflammasome activation is still unclear but free fatty acids have been proposed as one triggering event. Here we reported opposite effects of saturated fatty acids (SFAs) compared to unsaturated fatty acids (UFAs) on NLRP3 inflammasome in human monocytes/macrophages. Palmitate and stearate, both SFAs, triggered IL-1β secretion in a caspase-1/ASC/NLRP3-dependent pathway. Unlike SFAs, the UFAs oleate and linoleate did not lead to IL-1β secretion. In addition, they totally prevented the IL-1β release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers including nigericin, alum and MSU. UFAs did not affect the transcriptional effect of SFAs suggesting a specific effect on the NLRP3 activation. These results provide a new antiinflammatory mechanism of UFAs by preventing the activation of the NLRP3 inflammasome and therefore the IL-1β processing. By this way, UFAs might play a protective role in NLRP3-associated diseases. [less ▲]

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See detailBehavior of Deep Beams with Large Headed Bars
Mihaylov, Boyan ULg; Bentz, Evan; Collins, Michael

in ACI Structural Journal (2013), 110(6), 1013-1022

While anchor heads are particularly useful in the case of large bars which require significant development lengths, the ACI code provides design guidance for bars #11 or smaller. This paper presents a ... [more ▼]

While anchor heads are particularly useful in the case of large bars which require significant development lengths, the ACI code provides design guidance for bars #11 or smaller. This paper presents a test of a large deep beam reinforced with a single #18 headed bar. The behavior of the beam is evaluated in comparison to the behavior of a specimen with more conventional reinforcement of 6#8 headed bars, and to the behavior of a specimen with lap-spliced anchor hooks. Despite the extreme detailing of the specimen with a single #18 bar, the beam had the same strength as the specimen with 6#8 bars. The compressive stress in front of the anchor head reached about 1.5 times the compressive strength of the concrete and the stress in the #18 bar reached about 414 MPa (60 ksi) before the beam failed in shear along a diagonal crack away from the anchorage zone. Shear strength calculations according to Appendix A of the ACI code showed that the current strut-and-tie provisions can overestimate the shear strength of deep beams by as much as 23%. [less ▲]

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See detailPrevalence and Risk Factors for Various Cardiac Diseases in a Hospital-Based Population of 3434 Horses (1994-2011)
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Journal of Veterinary Internal Medicine (2013), 27(6), 1563-70

Background: Risk factors for several cardiac diseases have been suspected in horses, but few have been statistically demonstrated in a large equine population. Objectives: To describe risk factors for ... [more ▼]

Background: Risk factors for several cardiac diseases have been suspected in horses, but few have been statistically demonstrated in a large equine population. Objectives: To describe risk factors for various cardiac diseases in a hospital-based equine population. Animals: Files of 3434 horses admitted at the internal medicine department of the Liege Equine Teaching Hospital between 1994 and 2011were reviewed and of those, 284 were categorized as suffering from moderate to severe cardiac disease. Methods: Observational study. After calculating prevalence for each cardiac disease, we tested whether breed (chi-square test) or gender, age, body weight (BW) and other cardiac diseases (logistic regressions) were risk factors (p<0.05 significant). Results: Mitral regurgitation (MR, 4.4%), atrial fibrillation (AF, 2.3%), aortic regurgitation (AR, 2.1%) and tricuspid regurgitation (TR, 1.7%) were the most common cardiac abnormalities. Determinants were male gender and increasing age for AR (OR=2.03, CI=1.07-4.94), racehorses breed and middle-age for TR (OR=4.36; CI=1.10-17.24), and high BW for AF (OR=3.54; CI=1.67-7.49). MR was the major valvular disease associated with AF, pathological ventricular arrhythmia, pulmonary regurgitation (PR) and congestive heart failure (CHF). TR was also linked to AF, PR and CHF; AR was not linked to CHF. Conclusions and clinical importance: Several previously suspected risks factors of a variety of equine cardiac diseases are statistically confirmed in the studied hospital-based population. Similar observation could be suspected in a larger randomized population and should be taken into account in health and sport’s monitoring of horses presenting predisposing factors. [less ▲]

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See detail"La révocation des libéralités pour cause d'ingratitude"
Moreau, Pierre ULg

in Revue du Notariat Belge (2013), (3079), 734-765

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See detailProteomic Analysis of the Reproductive Organs of the Hermaphroditic Gastropod Lymnea stagnalis Exposed to Different Endocrine Disrupting Chemicals
Giusti, Arnaud ULg; Leprince, Pierre ULg; Mazzucchelli, Gabriel ULg et al

in PLoS ONE (2013), 8(11), 81086

Many studies have reported perturbations of mollusc reproduction following exposure to low concentrations (ng/L range) of endocrine disrupting chemicals (EDCs). However, the mechanisms of action of these ... [more ▼]

Many studies have reported perturbations of mollusc reproduction following exposure to low concentrations (ng/L range) of endocrine disrupting chemicals (EDCs). However, the mechanisms of action of these molecules on molluscs are still poorly understood. Investigation of the modifications of protein expression in organisms exposed to chemicals using proteomic methods can provide a broader and more comprehensive understanding of adverse impacts of pollution on organisms than conventional biochemical biomarkers (e.g., heat-shock proteins, metallothioneins, GST, EROD). In this study we have investigated the impacts of four chemicals, which exhibit different endocrine disrupting properties in vertebrates, on the proteome of the hermaphroditic freshwater pulmonate gastropod Lymnaea stagnalis after 21 days of exposure. Testosterone, tributyltin, chlordecone and cyproterone acetate were chosen as tested compounds as they can induce adverse effects on the reproduction of this snail. The 2D-DIGE method was used to identify proteins whose expression was affected by these compounds. In addition to modifying the expression of proteins involved in the structure and function of the cytoskeleton, chemicals had impacts on the expression of proteins involved in the reproduction of L. stagnalis. Exposure to 19.2 μg/L of chlordecone increased the abundance of ovipostatin, a peptide transmitted during mating through seminal fluid, which reduces oviposition in this species. The expression of yolk ferritin, the vitellogenin equivalent in L. stagnalis, was reduced after exposure to 94.2 ng Sn/L of tributyltin. The identification of yolk ferritin and the modification of its expression in snails exposed to chemicals were refined using western blot analysis. Our results showed that the tested compounds influenced the abundance of yolk ferritin in the reproductive organs. Alteration in proteins involved in reproductive pathways (e.g., ovipostatin and yolk ferritin) could constitute relevant evidence of interaction of EDCs with reproductive pathways that are under the control of the endocrine system of L. stagnalis. [less ▲]

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See detailRole of sea ice in global biogeochemical cycles: Emerging views and challenges
Vancoppenolle, M; Meiners, K.M.; Michel, C. et al

in Quaternary Science Reviews (2013), 79

Observations from the last decade suggest an important role of sea ice in the global biogeochemical cycles, promoted by (i) active biological and chemical processes within the sea ice; (ii) fluid and gas ... [more ▼]

Observations from the last decade suggest an important role of sea ice in the global biogeochemical cycles, promoted by (i) active biological and chemical processes within the sea ice; (ii) fluid and gas exchanges at the sea ice interface through an often permeable sea ice cover; and (iii) tight physical, biological and chemical interactions between the sea ice, the ocean and the atmosphere. Photosynthetic micro-organisms in sea ice thrive in liquid brine inclusions encased in a pure ice matrix, where they find suitable light and nutrient levels. They extend the production season, provide a winter and early spring food source, and contribute to organic carbon export to depth. Under-ice and ice edge phytoplankton blooms occur when ice retreats, favoured by increasing light, stratification, and by the release of material into the water column. In particular, the release of iron – highly concentrated in sea ice – could have large effects in the iron-limited Southern Ocean. The export of inorganic carbon transport by brine sinking below the mixed layer, calcium carbonate precipitation in sea ice, as well as active iceatmosphere carbon dioxide (CO2) fluxes, could play a central role in the marine carbon cycle. Sea ice processes could also significantly contribute to the sulphur cycle through the large production by ice algae of dimethylsulfoniopropionate (DMSP), the precursor of sulfate aerosols, which as cloud condensation nuclei have a potential cooling effect on the planet. Finally, the sea ice zone supports significant ocean-atmosphere methane (CH4) fluxes, while saline ice surfaces activate springtime atmospheric bromine chemistry, setting ground for tropospheric ozone depletion events observed near both poles. All these mechanisms are generally known, but neither precisely understood nor quantified at large scales. As polar regions are rapidly changing, understanding the large-scale polar marine biogeochemical processes and their future evolution is of high priority. Earth system models should in this context prove essential, but they currently represent sea ice as biologically and chemically inert. Paleoclimatic proxies are also relevant, in particular the sea ice proxies, inferring past sea ice conditions from glacial and marine sediment core records and providing analogs for future changes. Being highly constrained by marine biogeochemistry, sea ice proxies would not only contribute to but also benefit from a better understanding of polar marine biogeochemical cycles. [less ▲]

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See detailLe log book :un support d'apprentissage, d'accompagnement et d'évaluation des compétences professionnelles
VIERSET, Viviane ULg

in Bulletin de l'ADMEE-Europe (2013)

Développement pratico-pratique de l'usage du log book comme support d'une posture réflexive.

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See detailIdentity in schizophrenia: A study of trait self-knowledge
Boulanger, Marie ULg; Dethier, Marie ULg; Gendre, Francis et al

in Psychiatry Research (2013), 209(3), 367-374

Identity results from interlock of two systems which are a set of abstracted representations about oneself and a phenomenological self. Literature highlights identity disturbance in schizophrenia that ... [more ▼]

Identity results from interlock of two systems which are a set of abstracted representations about oneself and a phenomenological self. Literature highlights identity disturbance in schizophrenia that affects each of both systems. In the same vein, the present study investigates the stability and the quality of traits self-knowledge, a component of abstracted representations of self, in schizophrenia patients. Sixty-eight patients with schizophrenia and 68 healthy control subjects completed a short version of a personality scale (LABEL). This scale is composed of two versions (A and B), each comprising 50 adjectives that correspond to synonymous adjectives in the alternate list. Participants indicated how these adjectives described themselves and completed both versions of the scale on two separate occasions, one month apart. The findings showed that schizophrenic patients presented an unstable identity and change in identity quality compared with healthy subjects. However, this identity disturbance was weaker than expected. These results are discussed in a part of autobiographical memory disturbances in schizophrenia, illness duration and the decompensation stage. [less ▲]

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See detailPolarization radiation of vortex electrons with large orbital angular momentum
Ivanov, Igor ULg; Karlovets, Dmitry

in Physical Review. A (2013), 88(4), 043840

Vortex electrons—freely propagating electrons whose wave functions have helical wave fronts—could become a novel tool in the physics of electromagnetic radiation. They carry a nonzero intrinsic orbital ... [more ▼]

Vortex electrons—freely propagating electrons whose wave functions have helical wave fronts—could become a novel tool in the physics of electromagnetic radiation. They carry a nonzero intrinsic orbital angular momentum (OAM) ℓ with respect to the propagation axis and, for ℓ≫1, a large OAM-induced magnetic moment μ≈ℓμB (μB is the Bohr magneton), which influences the radiation of electromagnetic waves. Here, we consider in detail the OAM-induced effects caused by such electrons in two forms of polarization radiation, namely, in Cherenkov radiation and transition radiation. Thanks to the large ℓ, we can neglect quantum or spin-induced effects, which are of the order of ℏω/Ee≪1, but retain the magnetic moment contribution ℓℏω/Ee≲1, which makes the quasiclassical approach to polarization radiation applicable. We discuss the magnetic moment contribution to polarization radiation, which has never been experimentally observed, and study how its visibility depends on the kinematical parameters and the medium permittivity. In particular, it is shown that this contribution can, in principle, be detected in azimuthally nonsymmetrical problems, for example when vortex electrons obliquely cross a metallic screen (transition radiation) or move near it (diffraction radiation). We predict a left-right angular asymmetry of the transition radiation (in the plane where the charge radiation distributions would stay symmetric), which appears due to an effective interference between the charge radiation field and the magnetic moment contribution. Numerical values of this asymmetry for vortex electrons with Ee=300 keV and ℓ=100–1000 are 0.1%–1%, and we argue that this effect could be detected with existing technology. The finite conductivity of the target and frequency dispersion play crucial roles in these predictions. [less ▲]

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See detailAn unsaturated hydro-mechanical modelling of two in-situ experiments in Callovo-Oxfordian argillite
Charlier, Robert ULg; Collin, Frédéric ULg; Pardoen, Benoît ULg et al

in Engineering Geology (2013), 165

The unsaturated behaviour of Callovo-Oxfordian argillite is investigated through the modelling of 2 in-situ experiments. The first test studies the influence of ventilation in a gallery on the hydro ... [more ▼]

The unsaturated behaviour of Callovo-Oxfordian argillite is investigated through the modelling of 2 in-situ experiments. The first test studies the influence of ventilation in a gallery on the hydro-mechanical behaviour of the rock mass. The second test consists in a gas injection in the rock mass from an experimental borehole. A hydro-mechanical model is described and used in the modelling of the experiments. A review of the main hydro-mechanical parameters of argillite is presented. The numerical results highlight the need of a flow boundary condition reproducing the fluid transfers between the surroundings and the rock mass. The influence of dissolved gas on the compressibility of the liquid phase is also emphasised. [less ▲]

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See detailSpinal Cord Injuries – How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?
Neirinckx, Virginie ULg; CANTINIEAUX, Dorothée ULg; Coste, Cécile ULg et al

in Stem Cells (2013)

Since several years, adult/perinatal mesenchymal and neural crest stem cells have been widely used to help experimental animal to recover from spinal cord injury. More interestingly, recent clinical ... [more ▼]

Since several years, adult/perinatal mesenchymal and neural crest stem cells have been widely used to help experimental animal to recover from spinal cord injury. More interestingly, recent clinical trials confirmed the beneficial effect of those stem cells, which improve functional score of patients suffering from such lesions. However, a complete understanding of the mechanisms of stem cell-induced recovery is seriously lacking. Indeed, spinal cord injuries gathered a wide range of biochemical and physiopathological events (such as inflammation, oxidative stress, axonal damage, demyelination, etc) and the genuine healing process after cell transplantation is not sufficiently defined. This review aims to sum up recent data about cell therapy in spinal cord lesions using mesenchymal or recently identified neural crest stem cells, by describing precisely which physiopathological parameter is affected and the exact processes underlying the observed changes. Overall, although significant advances are acknowledged, it seems that further deep mechanistic investigation is needed for the development of optimized and efficient cell-based therapy protocols. [less ▲]

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See detailPhotosynthesis-dependent isoprene emission from leaf to planet in a global carbon-chemistry-climate model
Unger, N.; Harper, K.; Zheng, Y. et al

in Atmospheric Chemistry and Physics (2013), 13

We describe the implementation of a biochemical model of isoprene emission that depends on the electron requirement for isoprene synthesis into the Farquhar–Ball–Berry leaf model of photosynthesis and ... [more ▼]

We describe the implementation of a biochemical model of isoprene emission that depends on the electron requirement for isoprene synthesis into the Farquhar–Ball–Berry leaf model of photosynthesis and stomatal conductance that is embedded within a global chemistry-climate simulation framework. The isoprene production is calculated as a function of electron transport-limited photosynthesis, intercellular and atmospheric carbon dioxide concentration, and canopy temperature. The vegetation biophysics module computes the photosynthetic uptake of carbon dioxide coupled with the transpiration of water vapor and the isoprene emission rate at the 30 min physical integration time step of the global chemistry-climate model. In the model, the rate of carbon assimilation provides the dominant control on isoprene emission variability over canopy temperature. A control simulation representative of the present-day climatic state that uses 8 plant functional types (PFTs), prescribed phenology and generic PFT-specific isoprene emission potentials (fraction of electrons available for isoprene synthesis) reproduces 50% of the variability across different ecosystems and seasons in a global database of 28 measured campaign-average fluxes. Compared to time-varying isoprene flux measurements at 9 select sites, the model authentically captures the observed variability in the 30 min average diurnal cycle (R2 = 64–96 %) and simulates the flux magnitude to within a factor of 2. The control run yields a global isoprene source strength of 451 TgC yr−1 that increases by 30% in the artificial absence of plant water stress and by 55% for potential natural vegetation. [less ▲]

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See detailReprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato
Mariutto, Martin; Fauconnier, Marie-Laure ULg; Ongena, Marc ULg et al

in Plant Molecular Biology (2013), Online First Articles

The rhizobacterium Pseudomonas putida BTP1 stimulates induced systemic resistance (ISR) in tomato. A previous work showed that the resistance is associated in leaves with the induction of the first enzyme ... [more ▼]

The rhizobacterium Pseudomonas putida BTP1 stimulates induced systemic resistance (ISR) in tomato. A previous work showed that the resistance is associated in leaves with the induction of the first enzyme of the oxylipin pathway, the lipoxygenase (LOX), leading to a faster accumulation of its product, the free 13-hydroperoxy octadecatrienoic acid (13-HPOT), 2 days after Botrytis cinerea inoculation. In the present study, we further investigated the stimulation of the oxylipin pathway: metabolites and enzymes of the pathway were analyzed to understand the fate of the 13-HPOT in ISR. Actually the stimulation began upstream the LOX: free linolenic acid accumulated faster in P. putida BTP1-treated plants than in control. Downstream, the LOX products 13-fatty acid hydroperoxides esterified to galactolipids and phospholipids were more abundant in bacterized plants than in control before infection. These metabolites could constitute a pool that will be used after pathogen attack to produce free fungitoxic metabolites through the action of phospholipase A2, which is enhanced in bacterized plants upon infection. Enzymatic branches which can use as substrate the fatty acid hydroperoxides were differentially regulated in bacterized plants in comparison to control plants, so as to lead to the accumulation of the most fungitoxic compounds against B. cinerea. Our study, which is the first to demonstrate the accumulation of an esterified defense metabolite during rhizobacteria-mediated induced systemic resistance, showed that the oxylipin pathway is differentially regulated. It suggests that this allows the plant to prepare to a future infection, and to respond faster and in a more effective way to B. cinerea invasion. [less ▲]

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See detailMonocatenary, branched, double-headed and bolaform surface active carbohydrate esters via photochemical thiol-ene/-yne reactions
Boyère, Cédric ULg; Broze, Guy ULg; Blecker, Christophe ULg et al

in Carbohydrate Research (2013), 380

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated ... [more ▼]

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated hydrothiolation reaction involving a thiolated mannose was successfully applied to terminal and internal alkenes, dienes and alkynes, leading to monocatenary, branched, double-headed and bolaform amphiphilic carbohydrate esters,respectively. A surface activity study showed that these new compounds possess valuable properties and display specific behavior at the air-water interface. It also demonstrated the greater flexibility of the thioether moiety in the spacer of the surfactants produced via a thiol-ene reaction in comparison withthe triazole heterocyclic rings in similar glucose-based surfactants synthesized elsewhere by the alkyne-azide 1,3-dipolar addition. [less ▲]

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See detailDevelopment and validation of a UHPLC−LTQ−Orbitrap MS method for non-anthocyanin flavonoids quantification in Euterpe oleracea juice
Dias, A.L.; Rozet, Eric ULg; Larondelle, Y. et al

in Analytical and Bioanalytical Chemistry (2013)

Euterpe oleracea fruits have gained much attention because of their phenolic constituents that have shown potential beneficial effects for health. The aim of this work was to identify and quantify major ... [more ▼]

Euterpe oleracea fruits have gained much attention because of their phenolic constituents that have shown potential beneficial effects for health. The aim of this work was to identify and quantify major non-anthocyanin flavonoids in fruit juice by an accurate UHPLC−LTQ−Orbitrap MS method. Fruits were processed to juice, lyophilized and defatted. The residue was then extracted with methanol by sonication and the extraction time optimized giving recovery rates > 90%. Solubilization of dried extract was realized using 40% MeOH which showed the best compromise for MS detection. For the UHPLC quantification, a HSS C18 column (1.8µm) was used with a gradient elution of methanol and water both with 0.1% formic acid. Total error and accuracy profiles were used as validation criteria. Seven compounds and their isomers were successfully separated, including the major non-anthocyanin flavonoids. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (< 15% relative bias), repeatability and intermediate precision (<13% RSD), selectivity, response function, linearity, LOD (ranged from 0.04 to 0.81 µg/mL) and LOQ (0.15 - 5.78 µg/mL) for 12 compounds were evaluated and the quantification method validated. Its applicability was demonstrated on real samples from different suppliers. Their qualitative and quantitative profiles were similar and some compounds were for the first time quantified. In addition eriodictyol was identified for the first time in this fruit along with 5 other flavonoids for which we proposed a possible structure. [less ▲]

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See detailDermal ultrastructure in collagen VI myopathy.
HERMANNS-LE THI KIM, Trinh ULg; PIERARD, Gérald ULg; Franchimont, Claudine ULg et al

in Ultrastructural Pathology (2013)

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See detailProgramming of neuroendocrine self in the thymus and its defect in neuroendocrine autoimmunity
Geenen, Vincent ULg; Bodart, Gwennaëlle ULg; Henry, Séverine et al

in Frontiers in Neuroscience (2013), 7

During centuries after its first description by Galen, the thymus has been considered only as a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the ... [more ▼]

During centuries after its first description by Galen, the thymus has been considered only as a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the development of T (thymo-dependent) lymphocytes. A unique thymus appeared for the first time in cartilaginous fishes some 500 millions years ago, in the same time or shortly after the emergence of the adaptive (acquired) immune system. The thymus may be compared to a small brain or a computer highly specialized in the orchestration of central immunological self-tolerance. This latter was a necessity for the survival of species given the potent evolutionary pressure impacted by the high risk of autotoxicity inherent to the stochastic generation of the diversity of immune cell receptors that characterize the adaptive immune response. The new paradigm of neuroendocrine self-peptides has been proposed together with the definition of neuroendocrine self. Neuroendocrine self-peptides are not secreted by thymic epithelial cells (TECs) according to the classic model of neuroendocrine signaling, but processed for a presentation by, or in association with, the thymic major histocompatibility complex (MHC) proteins. The autoimmune regulator (AIRE) gene/protein controls the transcription of neuroendocrine genes in TECs. The presentation of self-peptides in the thymus is responsible for the clonal deletion of self-reactive T cells emerging during the random recombination of gene segments that encode variable parts of the T cell receptor for the antigen (TCR). In the same time, self-antigen presentation in the thymus also generates regulatory T (Treg) cells that are able to inhibit in the periphery self-reactive T cells having escaped negative selection in the thymus. Several arguments show that the origin of autoimmunity directed against neuroendocrine glands primarily results from a defect in the intrathymic programming of self-tolerance to neuroendocrine functions. This defect may be genetic or acquired during an enteroviral infection, for example. This novel knowledge of normal and pathologic functions of the thymus already constitutes a solid basis for the development of a novel type of tolerogenic/negative self-vaccination against type 1 diabetes (T1D). [less ▲]

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See detailImproving solar dryers' performancs using design and thermal heat storage
Bennamoun, Lyes ULg

in Food Engineering Reviews (2013)

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See detailSynthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold
Nørholm, Ann-Beth; Francotte, Pierre ULg; Olsen, Lars et al

in Journal of Medicinal Chemistry (2013), 56(21), 87368745

Positive allosteric modulators of ionotropic glutamate receptors are potential compounds for treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind within the dimer interface of ... [more ▼]

Positive allosteric modulators of ionotropic glutamate receptors are potential compounds for treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind within the dimer interface of the ligand-binding domain (LBD) and stabilize the agonist-bound conformation, thereby slowing receptor desensitization and/or deactivation. Here we describe the synthesis and pharmacological testing at GluA2 of a new generation of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides. The most potent modulator 3 in complex with GluA2-LBD-L483Y-N754S was subjected to structural analysis by X-ray crystallography, and the thermodynamics of binding was studied by isothermal titration calorimetry. Compound 3 binds to GluA2-LBD-L483Y-N754S with a Kd of 0.35 μM (ΔH = −7.5 kcal/mol and −TΔS = −1.3 kcal/mol). This is the first time that submicromolar binding affinity has been achieved for this type of positive allosteric modulator. The major structural factor increasing the binding affinity of 3 seems to be interactions between the cyclopropyl group of 3 and the backbone of Phe495 and Met496. [less ▲]

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See detailLa collecte des déchets en Wallonie : organisation et performances
Gautier, Axel ULg; Reginster, Sophie ULg

in Regards Economiques (2013), (106),

En Wallonie, la collecte des déchets est fréquemment déléguée par les communes à une intercommunale ou à un collecteur privé. Par ailleurs, de plus en plus de communes utilisent des conteneurs à puce. Cet ... [more ▼]

En Wallonie, la collecte des déchets est fréquemment déléguée par les communes à une intercommunale ou à un collecteur privé. Par ailleurs, de plus en plus de communes utilisent des conteneurs à puce. Cet article compare les performances en termes de coûts de ces différentes alternatives. [less ▲]

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See detailDMFSGD: A Decentralized Matrix Factorization Algorithm for Network Distance Prediction
Liao, Yongjun ULg; Du, Wei; Geurts, Pierre ULg et al

in IEEE/ACM Transactions on Networking (2013), 21(5), 1511-1524

The knowledge of end-to-end network distances is essential to many Internet applications. As active probing of all pairwise distances is infeasible in large-scale networks, a natural idea is to measure a ... [more ▼]

The knowledge of end-to-end network distances is essential to many Internet applications. As active probing of all pairwise distances is infeasible in large-scale networks, a natural idea is to measure a few pairs and to predict the other ones without actually measuring them. This paper formulates the prediction problem as matrix completion where the unknown entries in a pairwise distance matrix constructed from a network are to be predicted. By assuming that the distance matrix has a low-rank characteristics, the problem is solvable by lowrank approximation based on matrix factorization. The new formulation circumvents the well-known drawbacks of existing approaches based on Euclidean embedding. A new algorithm, so-called Decentralized Matrix Factorization by Stochastic Gradient Descent (DMFSGD), is proposed. By letting network nodes exchange messages with each other, the algorithm is fully decentralized and only requires each node to collect and to process local measurements, with neither explicit matrix constructions nor special nodes such as landmarks and central servers. In addition, we compared comprehensively matrix factorization and Euclidean embedding to demonstrate the suitability of the former on network distance prediction. We further studied the incorporation of a robust loss function and of non-negativity constraints. Extensive experiments on various publicly-available datasets of network delays show not only the scalability and the accuracy of our approach, but also its usability in real Internet applications. [less ▲]

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See detailSynthesis of [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione: an agent for specific radiolabelling of tyrosine
Flagothier, Jessica ULg; Warnier, Corentin ULg; Dammicco, Sylvestre ULg et al

in RSC Advances (2013), 3

We developed a new [18F] prosthetic group, the [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione ([18F]FPTAD), used for its specific ligation with tyrosine-containing peptides or protein in order to ... [more ▼]

We developed a new [18F] prosthetic group, the [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione ([18F]FPTAD), used for its specific ligation with tyrosine-containing peptides or protein in order to develop a new and versatile radiolabelling technique that could provide a useful tool for new developments in PET imaging. [less ▲]

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See detailMyeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
Zouaoui Boudjeltia, Karim; Delporte, Cédric; Van Antwerpen, Pierre et al

in Mediators of Inflammation (2013), 2013

The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation ... [more ▼]

The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels. [less ▲]

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See detailThe multiple spots of the Ganymede auroral footprint
Bonfond, Bertrand ULg; Hess, Sébastien; Bagenal, Fran et al

in Geophysical Research Letters (2013), 40

The interaction between the moons and the magnetosphere of giant planets sometimes gives rise to auroral signatures in the planetary ionosphere, called the satellite footprints. So far, footprints have ... [more ▼]

The interaction between the moons and the magnetosphere of giant planets sometimes gives rise to auroral signatures in the planetary ionosphere, called the satellite footprints. So far, footprints have been detected for Io, Europa, Ganymede, and Enceladus. These footprints are usually seen as single spots. However, the Io footprint, the brightest one, displays a much more complex morphology made of at least three different spots and an extended tail. Here we present Hubble Space Telescope FUV images showing evidence for a second spot in the Ganymede footprint. The spots separation distance changes as Ganymede moves latitudinally in the plasma sheet, as is seen for the Io footprint. This indicates that the processes identified at Io are universal. Moreover, for similar Ganymede System III longitudes, the distance may also vary significantly with time, indicating changes in the plasma sheet density. We identified a rapid evolution of this distance 8 days after the detection of a volcanic outburst at Io, suggesting that such auroral observations could be used to estimate the plasma density variations at Ganymede. [less ▲]

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See detailDevelopment of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
Francotte, Pierre ULg; Goffin, Eric ULg; Fraikin, Pierre et al

in Journal of Medicinal Chemistry (2013), 56(20), 7838-7850

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the ... [more ▼]

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators. [less ▲]

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See detailDynamic Simulation of Large-scale Power Systems Using a Parallel Schur-complement-based Decomposition Method
Aristidou, Petros ULg; Fabozzi, Davide; Van Cutsem, Thierry ULg

in IEEE Transactions on Parallel and Distributed Systems (2013)

Power system dynamic simulations are crucial for the operation of electric power systems as they provide important information on the dynamic evolution of the system after an occurring disturbance. This ... [more ▼]

Power system dynamic simulations are crucial for the operation of electric power systems as they provide important information on the dynamic evolution of the system after an occurring disturbance. This paper proposes a robust, accurate and efficient parallel algorithm based on the Schur complement domain decomposition method. The algorithm provides numerical and computational acceleration of the procedure. Based on the shared-memory parallel programming model, a parallel implementation of the proposed algorithm is presented. The implementation is general, portable and scalable on inexpensive, shared-memory, multi-core machines. Two realistic test systems, a medium-scale and a large-scale, are used for performance evaluation of the proposed method. [less ▲]

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See detailPulsating B-type Stars in the Open Cluster NGC 884: Frequencies, Mode Identification, and Asteroseismology
Saesen, S.; Briquet, Maryline ULg; Aerts, C. et al

in Astronomical Journal (2013), 146

Recent progress in the seismic interpretation of field β Cep stars has resulted in improvements of the physical description in the stellar structure and evolution model computations of massive stars ... [more ▼]

Recent progress in the seismic interpretation of field β Cep stars has resulted in improvements of the physical description in the stellar structure and evolution model computations of massive stars. Further asteroseismic constraints can be obtained from studying ensembles of stars in a young open cluster, which all have similar age, distance, and chemical composition. We present an observational asteroseismology study based on the discovery of numerous multi-periodic and mono-periodic B stars in the open cluster NGC 884. We describe a thorough investigation of the pulsational properties of all B-type stars in the cluster. Overall, our detailed frequency analysis resulted in 115 detected frequencies in 65 stars. We found 36 mono-periodic, 16 bi-periodic, 10 tri-periodic, and 2 quadru-periodic stars and one star with nine independent frequencies. We also derived the amplitudes and phases of all detected frequencies in the U, B, V, and I filter, if available. We achieved unambiguous identifications of the mode degree for 12 of the detected frequencies in nine of the pulsators. Imposing the identified degrees and measured frequencies of the radial, dipole, and quadrupole modes of five pulsators led to a seismic cluster age estimate of log (age/yr) = 7.12-7.28 from a comparison with stellar models. Our study is a proof-of-concept for and illustrates the current status of ensemble asteroseismology of a young open cluster. [less ▲]

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See detailInference of Inhomogeneous Clouds in an Exoplanet Atmosphere
Demory, Brice-Olivier; de Wit, Julien; Lewis, Nikole et al

in Astrophysical Journal Letters (2013), 776

We present new visible and infrared observations of the hot Jupiter Kepler-7b to determine its atmospheric properties. Our analysis allows us to (1) refine Kepler-7b's relatively large geometric albedo of ... [more ▼]

We present new visible and infrared observations of the hot Jupiter Kepler-7b to determine its atmospheric properties. Our analysis allows us to (1) refine Kepler-7b's relatively large geometric albedo of Ag = 0.35 ± 0.02, (2) place upper limits on Kepler-7b thermal emission that remains undetected in both Spitzer bandpasses and (3) report a westward shift in the Kepler optical phase curve. We argue that Kepler-7b's visible flux cannot be due to thermal emission or Rayleigh scattering from H[SUB]2[/SUB] molecules. We therefore conclude that high altitude, optically reflective clouds located west from the substellar point are present in its atmosphere. We find that a silicate-based cloud composition is a possible candidate. Kepler-7b exhibits several properties that may make it particularly amenable to cloud formation in its upper atmosphere. These include a hot deep atmosphere that avoids a cloud cold trap, very low surface gravity to suppress cloud sedimentation, and a planetary equilibrium temperature in a range that allows for silicate clouds to potentially form in the visible atmosphere probed by Kepler. Our analysis does not only present evidence of optically thick clouds on Kepler-7b but also yields the first map of clouds in an exoplanet atmosphere. [less ▲]

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See detailTurbulent non-uniform flows in straight compound open-channels
Proust, S.; Fernandes, J. N.; Peltier, Yann ULg et al

in Journal of Hydraulic Research (2013)

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See detailDifferential asteroseismic study of seismic twins observed by CoRoT. Comparison of HD 175272 with HD 181420
Ozel, N.; Mosser, B.; Dupret, Marc-Antoine ULg et al

in Astronomy and Astrophysics (2013), 558

Context. The CoRoT short asteroseismic runs give us the opportunity to observe a large variety of late-type stars through their solar-like oscillations. We report the observation and modeling of the F5V ... [more ▼]

Context. The CoRoT short asteroseismic runs give us the opportunity to observe a large variety of late-type stars through their solar-like oscillations. We report the observation and modeling of the F5V star HD 175272. <BR /> Aims: Our aim is to define a method for extracting as much information as possible from a noisy oscillation spectrum. <BR /> Methods: We followed a differential approach that consists of using a well-known star as a reference to characterize another star. We used classical tools such as the envelope autocorrelation function to derive the global seismic parameters of the star. We compared HD 175272 with HD 181420 through a linear approach, because they appear to be asteroseismic twins. <BR /> Results: The comparison with the reference star enables us to substantially enhance the scientific output for HD 175272. First, we determined its global characteristics through a detailed seismic analysis of HD 181420. Second, with our differential approach, we measured the difference of mass, radius and age between HD 175272 and HD 181420. <BR /> Conclusions: We have developed a general method able to derive asteroseismic constraints on a star even in case of low-quality data. This method can be applied to stars with interesting properties but low signal-to-noise ratio oscillation spectrum, such as stars hosting an exoplanet or members of a binary system. The CoRoT space mission, launched on 2006 December 27, was developed and is operated by the CNES, with participation of the Science Programs of ESA, ESAs RSSD, Austria, Belgium, Brazil, Germany and Spain. [less ▲]

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See detailModeling of Weakly Conducting Thin Sheets in the Discontinuous Galerkin Method for Shielding Effectiveness Evaluation
Boubekeur, Mohamed; Kameni, Abelin; Modave, Axel ULg et al

in ACES Journal (2013), 28(10), 931

This paper presents a modeling of weakly conducting thin sheets in the time domain discontinuous Galerkin method. This interface condition is used to avoid the mesh of resistive sheets in order to ... [more ▼]

This paper presents a modeling of weakly conducting thin sheets in the time domain discontinuous Galerkin method. This interface condition is used to avoid the mesh of resistive sheets in order to evaluate the shielding effectiveness in high frequency electromagnetic compatibility problems. This condition is valid when the thickness of the sheet is smaller than the skin depth. This approach is validated by a comparison with an analytical solution. A 1D two sheets example, 2D and 3D cavities are treated to illustrate the efficiency of the condition. [less ▲]

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See detailANALYSE SPATIO-TEMPORELLE DES DÉGÂTS D’ÉCORCEMENT DANS LES PLANTATIONS RÉSINEUSES EN RÉGION WALLONNE
Ligot, Gauthier ULg; Lehaire, François ULg; Gheysen, Thibaut et al

in Forêt Wallonne (2013), 126

Les dégâts d’écorcement inquiètent de très nombreux gestionnaires forestiers. Depuis plus de 10 ans, des inventaires sont réalisés annuellement et des outils de diagnostic ont été développés afin d’en ... [more ▼]

Les dégâts d’écorcement inquiètent de très nombreux gestionnaires forestiers. Depuis plus de 10 ans, des inventaires sont réalisés annuellement et des outils de diagnostic ont été développés afin d’en quantifier l’ampleur en Région wallonne. L’examen de ces données met en évidence le rôle prépondérant des densités de cerfs ainsi que de la structure du paysage, de la rigueur des hivers et de la capacité d’accueil du milieu. [less ▲]

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See detailJacks of all trades and masters of some
Rigo, Philippe ULg

in Naval Architect (2013)

Presentation of the EMSHIP - Erasmus Mundus Programme

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See detailLes matrices métalliques et céramiques : de nouveaux matériaux composites
Montrieux, Henri-Michel ULg; Lecomte-Beckers, Jacqueline ULg; Mertens, Anne ULg

in Plus Composites (2013), article n°3

Le présent article décrit différentes limitations des matériaux composites à matrice polymère. Outre l’amélioration de la formulation des résines, une des alternatives qui se présente est d’employer une ... [more ▼]

Le présent article décrit différentes limitations des matériaux composites à matrice polymère. Outre l’amélioration de la formulation des résines, une des alternatives qui se présente est d’employer une matrice métallique ou céramique. Certains de ces matériaux nouveaux sont toujours au stade du développement. Il s’agit par exemple des composites pour applications structurales avec une matrice légère en aluminium ou en magnésium pour lesquels les rapports rigidité-poids et résistance-poids sont élevés. La résilience est aussi améliorée par rapport aux matrices classiques simplement renforcées. D’autres composites à matrice métallique tels que les cermets sont industrialisés comme outils de coupe. Des composites à matrice céramique comme le carbone-carbone ou le carbone-SiC peuvent être industrialisés et présentent une durabilité et une température d’utilisation maximale exceptionnelle. Pour terminer, l’article fournit quelques informations sur les techniques nouvelles de mise à forme des matériaux composites telles que le friction stir processing et l’additive manufacturing. [less ▲]

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See detailPrecise Through Wall Angular Position Sensor Compatible with Cryogenic Temperature for Space Launcher
Carapelle, Alain ULg; Martin, Nicolas ULg; Chantraine, Thierry ULg

in Sensor Letters (2013), 11(10), 1992-1995

A new rotation sensor is developed and tested for the next generation of Ariane space launchers. It aimed at measuring accurately the angular position of an admission valve (target sensitivity of 0.01° ... [more ▼]

A new rotation sensor is developed and tested for the next generation of Ariane space launchers. It aimed at measuring accurately the angular position of an admission valve (target sensitivity of 0.01°) from cryogenic (4K) to room temperature without recalibration. The measurement has to be done contactless and through pipe walls. Innovative electromagnetic application, cryogenic design and data treatment allows reaching the specifications. [less ▲]

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See detailThe auditory P300-based single-switch brain–computer interface:Paradigm transition from healthy subjects to minimally consciouspatients
Pokorny, Christoph; Klobassa, Daniela; Pichler, Gerald et al

in Artificial Intelligence in Medicine (2013), 59(2), 81-90

Objective: Within this work an auditory P300 brain–computer interface based on tone stream segregation,which allows for binary decisions, was developed and evaluated.Methods and materials: Two tone ... [more ▼]

Objective: Within this work an auditory P300 brain–computer interface based on tone stream segregation,which allows for binary decisions, was developed and evaluated.Methods and materials: Two tone streams consisting of short beep tones with infrequently appearingdeviant tones at random positions were used as stimuli. This paradigm was evaluated in 10 healthysubjects and applied to 12 patients in a minimally conscious state (MCS) at clinics in Graz, Würzburg,Rome, and Liège. A stepwise linear discriminant analysis classifier with 10 × 10 cross-validation was usedto detect the presence of any P300 and to investigate attentional modulation of the P300 amplitude.Results: The results for healthy subjects were promising and most classification results were better thanrandom. In 8 of the 10 subjects, focused attention on at least one of the tone streams could be detectedon a single-trial basis. By averaging 10 data segments, classification accuracies up to 90.6 % could bereached. However, for MCS patients only a small number of classification results were above chance leveland none of the results were sufficient for communication purposes. Nevertheless, signs of consciousnesswere detected in 9 of the 12 patients, not on a single-trial basis, but after averaging of all correspondingdata segments and computing significant differences. These significant results, however, strongly variedacross sessions and conditions.Conclusion: This work shows the transition of a paradigm from healthy subjects to MCS patients. Promisingresults with healthy subjects are, however, no guarantee of good results with patients. Therefore, moreinvestigations are required before any definite conclusions about the usability of this paradigm for MCSpatients can be drawn. Nevertheless, this paradigm might offer an opportunity to support bedside clinicalassessment of MCS patients and eventually, to provide them with a means of communication. [less ▲]

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See detailMassive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites During Primary Infection
Gillet, Nicolas ULg; Gutiérrez, Gerónimo; Rodriguez, Sabrina ULg et al

in PLoS Pathogens (2013), 9(10),

Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection generally asymptomatic but can also lead to leukemia or lymphoma. These ... [more ▼]

Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection generally asymptomatic but can also lead to leukemia or lymphoma. These viruses replicate by infecting new lymphocytes (i.e. the infectious cycle) or via clonal expansion of the infected cells (mitotic cycle). The relative importance of these two cycles in viral replication varies during infection. The majority of infected clones are created early before the onset of an efficient immune response. Later on, the main replication route is mitotic expansion of pre-existing infected clones. Due to the paucity of available samples and for ethical reasons, only scarce data is available on early infection by HTLV-1. Therefore, we addressed this question in a comparative BLV model. We used high-throughput sequencing to map and quantify the insertion sites of the provirus in order to monitor the clonality of the BLV-infected cells population (i.e. the number of distinct clones and abundance of each clone). We found that BLV propagation shifts from cell neoinfection to clonal proliferation in about 2 months from inoculation. Initially, BLV proviral integration significantly favors transcribed regions of the genome. Negative selection then eliminates 97% of the clones detected at seroconversion and disfavors BLV-infected cells carrying a provirus located close to a promoter or a gene. Nevertheless, among the surviving proviruses, clone abundance positively correlates with proximity of the provirus to a transcribed region. Two opposite forces thus operate during primary infection and dictate the fate of long term clonal composition: (1) initial integration inside genes or promoters and (2) host negative selection disfavoring proviruses located next to transcribed regions. The result of this initial response will contribute to the proviral load set point value as clonal abundance will benefit from carrying a provirus in transcribed regions. [less ▲]

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See detailReview Contrastive Pragmatics. 2011. Amsterdam/ Philadelphia: John Benjamins. ISBN 978 90 272 2260 2. 182 pp.
Brems, Lieselotte ULg

in English Text Construction (2013), 2(6), 301-305

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See detailRécit et interactivité : typologie des interactions narratives
Hurel, Pierre-Yves ULg

in Mosaïque (2013), 10

The aim of this article is to provide a first typology of structural elements of storytelling that can be used for narrative interactivy; we define it as the possibilities for the user of a interactive ... [more ▼]

The aim of this article is to provide a first typology of structural elements of storytelling that can be used for narrative interactivy; we define it as the possibilities for the user of a interactive storytelling to influence the story developments. Furthermore, we will also discuss the links between narrative interactivity and other types of interactions. Our approach is a problematic of involvment (that we oppose to the concept of participation), which allows us to stress the continuity between the reception (too often thought of as passive) and interaction itself. The typology is built on the basis of Françoise Revaz's definition of narrativity degrees. The article ends with a first application through a descriptive analysis of three video games and a web documentary. [less ▲]

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See detailStaging chronic kidney disease and estimating glomerular filtration rate: an opinion paper about the new international recommendations
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 1911-1917

Abstract: In January 2013, the international recommendations <br />of the KDIGO (for “ Kidney Disease: Improving <br />Global Outcomes ” ) to define chronic kidney disease <br />(CKD) and classify ... [more ▼]

Abstract: In January 2013, the international recommendations <br />of the KDIGO (for “ Kidney Disease: Improving <br />Global Outcomes ” ) to define chronic kidney disease <br />(CKD) and classify patients in CKD stages have been published. <br />In this opinion article, we will review and discuss <br />the most important guidelines proposed about CKD staging <br />and glomerular filtration rate (GFR) estimating. In <br />particular, we question the choice of fixed knot values <br />at 60 mL/min/1.73 m ² to define CKD. We also question <br />the strategies proposed to measure and use cystatin C <br />results. [less ▲]

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See detailElectroencephalographic profiles for differentiation of disorders of consciousness.
Malinowska, U; Chatelle, Camille ULg; Bruno, Marie-Aurélie ULg et al

in BioMedical Engineering OnLine (2013), 12

BACKGROUND: Electroencephalography (EEG) is best suited for long-term monitoring of brain functions in patients with disorders of consciousness (DOC). Mathematical tools are needed to facilitate efficient ... [more ▼]

BACKGROUND: Electroencephalography (EEG) is best suited for long-term monitoring of brain functions in patients with disorders of consciousness (DOC). Mathematical tools are needed to facilitate efficient interpretation of long-duration sleep-wake EEG recordings. METHODS: Starting with matching pursuit (MP) decomposition, we automatically detect and parametrize sleep spindles, slow wave activity, K-complexes and alpha, beta and theta waves present in EEG recordings, and automatically construct profiles of their time evolution, relevant to the assessment of residual brain function in patients with DOC. RESULTS: Above proposed EEG profiles were computed for 32 patients diagnosed as minimally conscious state (MCS, 20 patients), vegetative state/unresponsive wakefulness syndrome (VS/UWS, 11 patients) and Locked-in Syndrome (LiS, 1 patient). Their interpretation revealed significant correlations between patients' behavioral diagnosis and: (a) occurrence of sleep EEG patterns including sleep spindles, slow wave activity and light/deep sleep cycles, (b) appearance and variability across time of alpha, beta, and theta rhythms. Discrimination between MCS and VS/UWS based upon prominent features of these profiles classified correctly 87 % of cases. CONCLUSIONS: Proposed EEG profiles offer user-independent, repeatable, comprehensive and continuous representation of relevant EEG characteristics, intended as an aid in differentiation between VS/UWS and MCS states and diagnostic prognosis. To enable further development of this methodology into clinically usable tests, we share user-friendly software for MP decomposition of EEG (http://braintech.pl/svarog) and scripts used for creation of the presented profiles (attached to this article). [less ▲]

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See detailA multiaxial constitutive model for concrete in the fire situation: Theoretical formulation.
Gernay, Thomas ULg; Millard, Alain; Franssen, Jean-Marc ULg

in International Journal of Solids and Structures (2013), 50(22-23), 3659-3673

This paper aims to develop a multiaxial concrete model for implementation in finite element softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a ... [more ▼]

This paper aims to develop a multiaxial concrete model for implementation in finite element softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a challenging task in structural fire engineering because of the complexity of the concrete mechanical behavior characterization and the severe requirements for the material models raised by the development of performance-based design. A fully threedimensional model is developed based on the combination of elastoplasticity and damage theories. The state of damage in concrete, assumed isotropic, is modeled by means of a fourth order damage tensor to capture the unilateral effect. The concrete model comprises a limited number of parameters that can be identified by three simple tests at ambient temperature. At high temperatures, a generic transient creep model is included to take into account explicitly the effect of transient creep strain. The numerical implementation of the concrete model in a finite element software is presented and a series of numerical simulations are conducted for validation. The concrete behavior is accurately captured in a large range of temperature and stress states. A limitation appears when modeling the concrete post-peak behavior in highly confined stress states, due to the coupling assumption between damage and plasticity, but the considered levels of triaxial confinement are unusual stress states in structural concrete. [less ▲]

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See detailFifty years of crop residue management have a limited impact on soil heterotrophic respiration.
Buysse, Pauline ULg; Schnepf-Kiss, Anne-Caroline; Carnol, Monique ULg et al

in Agricultural and Forest Meteorology (2013), 180

The impacts of crop residue management on soil microbial biomass, labile carbon and heterotrophic respiration (HR) were assessed at a long-term experimental site in the Hesbaye region in Belgium. Three ... [more ▼]

The impacts of crop residue management on soil microbial biomass, labile carbon and heterotrophic respiration (HR) were assessed at a long-term experimental site in the Hesbaye region in Belgium. Three treatments, residue export (RE), farmyard manure addition (FYM) and residue restitution after harvest (RR), have been applied continuously since 1959. The soil is a Eutric Cambisol with, in 2010, significantly different total soil organic carbon contents of 4.4, 5.1 and 5.9 kg C m-2 under the RE, RR and FYM treatments, respectively. Manual field HR measurements were carried out during the 2010 and 2012 crop seasons using a dynamic closed chamber system. Microbial biomass, labile C content and metabolic diversity of soil bacteria were assessed in spring 2012. Fifty-one years after the beginning of the treatments, residue management had a limited impact on HR. Based on daily averaged values, the treatment had a significant impact (α = 10%) in 2012 but not in 2010. Based on the individual measurement dates, the treatment impact was less obvious in 2012; with the observation of a significant impact (α = 10%) on HR in only 7% and 36.8% of the measurement dates in 2010 and 2012, respectively. Labile C and microbial biomass were significantly lower in the RE treatment than in FYM and RR. Residue management had no significant effect on cold-water extracted carbon and metabolic diversity of heterotrophic soil bacteria. The limited impact of residue management on HR could be explained by (i) the relatively low amounts of recent above-ground crop inputs, (ii) the large proportion of below-ground residues and other non-exportable above-ground residues reducing the potential differences between treatments and (iii) the relatively large spatial variability of HR. In conclusion, carbon losses due to heterotrophic respiration did not differ between RE, FYM and RR treatments in the studied soil. This contrasts with the different soil organic carbon contents observed in these three treatments after fifty years of experiment. Further investigations regarding the reduction of spatial variability and the potential roles played by organic matter protection within aggregates and biochemical composition of inputs are needed. [less ▲]

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See detailIl n'est jamais trop tard pour apprendre à (bien) lire ...
Bruyère, Olivier ULg

in Medi-Sphere (2013), 421

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See detailCaractériser l’environnement de travail du soignant à domicile: un enjeu pour le développement de l'Education Thérapeutique du Patient
Heyden, Isabelle ULg; Mollo, Vanina

in Activités (2013), 10(2),

A patient's therapeutic education is a permanent process which includes various organized activities that contribute towards the patient’s quality of life and help reduce long-term care costs. Whilst it ... [more ▼]

A patient's therapeutic education is a permanent process which includes various organized activities that contribute towards the patient’s quality of life and help reduce long-term care costs. Whilst it may be a solution to the increase in chronic diseases and care needs, it is nevertheless little valued financially in the Belgium home care. Home care would nevertheless appear to have developed quite significantly. It is however, difficult to grasp. In order to identify the determinants of patient education at home, sixty semi-structured interviews were carried out with managers, nurses and auxiliary nurses from twenty home care services in French-speaking areas of Belgium. Patient education at home is determined by multiple factors relating to the patient (request, involvement, capacities…), the caregiver (involvement, desire to spend time on the patient's education, professional education…), the relationship (trust, affinity, respect…), the service (organization of working time, resources…) and supranational authorities (amount and current method of funding). Some determinants are real levers through which supranational authorities and home care services can be operated. [less ▲]

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See detailRilouke, une cellule de surveillance des défauts génétiques dans la race blanc bleu belge
Sartelet, Arnaud ULg; Tamma, Nico ULg; Chapon, Samuel et al

in Point Vétérinaire (2013), 339

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See detailFormation : il y a encore du chemin !
Vanmeerbeek, Marc ULg

in Santé Conjuguée (2013), 66

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See detailL'hyperthyroidie neonatale: clinique et prise en charge therapeutique.
Petignot, S.; NYAMUGABO MUNYERE NKANA, Kindja ULg; Socin, H. Valdes et al

in Revue medicale de Liege (2013), 68(10), 531-6

Neonatal hyperthyroidism is a rare pathology, most often the consequence of Graves' disease in the mother. Around 0.2% of pregnant women have Graves disease and 1 to 2% of newborns of mother with Graves ... [more ▼]

Neonatal hyperthyroidism is a rare pathology, most often the consequence of Graves' disease in the mother. Around 0.2% of pregnant women have Graves disease and 1 to 2% of newborns of mother with Graves' disease. This article will describe the case of 4 newborns who have been diagnosed and treated in CHU-NDB between 2007 and 2011. The second part will focus on the new recommendations about the management of these young patients from foetal period to birth. [less ▲]

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See detailHubble observations of Jupiter’s north–south conjugate ultraviolet aurora
Gérard, Jean-Claude ULg; Grodent, Denis ULg; Radioti, Aikaterini ULg et al

in Icarus (2013), 226

Comparisons of the northern and southern far ultraviolet (UV) auroral emissions of Jupiter from the Hubble Space Telescope (HST) or any other ultraviolet imager have mostly been made so far on a ... [more ▼]

Comparisons of the northern and southern far ultraviolet (UV) auroral emissions of Jupiter from the Hubble Space Telescope (HST) or any other ultraviolet imager have mostly been made so far on a statistical basis or were not obtained with high sensitivity and resolution. Such observations are important to discriminate between different mechanisms responsible for the electron acceleration of the different components of the aurora such as the satellite footprints, the «main oval» or the polar emissions. The field of view of the ACS and STIS cameras on board HST is not wide enough to provide images of the full jovian disk. We thus compare the morphology of the north and south aurora observed 55 min apart and we point out similarities and differences. On one occasion HST pointed successively the two polar regions and auroral images were seen separated by only 3 min. This makes it possible to compare the emission structure and the emitted FUV power of corresponding regions. We find that most morphological features identified in one hemisphere have a conjugate counterpart in the other hemisphere. However, the power associated with conjugate regions of the main oval, diffuse or discrete equatoward emission observed quasi-simultaneously may be different in the two hemispheres. It is not directly nor inversely proportional to the strength of the B-field as one might expect for diffuse precipitation or field-aligned acceleration with equal ionospheric electron density in both hemispheres. Finally, the lack of symmetry of some polar emissions suggests that some of them could be located on open magnetic field lines. [less ▲]

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See detailPolarization holography for vortex retarders recording
Piron, Pierre ULg; Blain, Pascal ULg; Mawet, Dimitri et al

in Applied Optics (2013), 52(28), 7040-7048

We present an original static recording method for vortex retarders (VRs) made from liquid crystal polymers (LCPs) using the superimposition of several polarized beams. VRs are birefringent plates ... [more ▼]

We present an original static recording method for vortex retarders (VRs) made from liquid crystal polymers (LCPs) using the superimposition of several polarized beams. VRs are birefringent plates characterized by a rotation of their fast axis about their center. The new method is based on polarization holography and photo-orientable LCP. Combining several polarized beams induces the polarization patterns required for the recording process of VRs without mechanical action. A mathematical description of the method, the outcomes of the numerical simulations, and the first experimental results are presented. [less ▲]

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See detailLes défauts héréditaires dans la race blanc bleu belge
Sartelet, Arnaud ULg

in Point Vétérinaire (2013), 339

Cette fiche présente les tableaux cliniques et les données épidémiologiques (fondateurs, fréquences de chaque mutation) et génétiques (cartographie, gènes et mutations causales) de chaque maladie.

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See detailThe Reputation Effect: A Case Study of Credit Contracts in Transition Countries
Artige, Lionel ULg; Nicolini, Rosella

in SSRN Working Paper (2013)

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See detailEffects of 3 months of aerobic training on fitness of Parkinson's disease patients
Demonceau, Marie ULg; rodriguez de la Cruz, carlos; kalimira, kinja et al

in Annals of Physical and Rehabilitation Medicine (2013)

Objectives.– To assess the effects of an aerobic training for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn & Yahr stage [1] < III of PD were allocated to either 3 months of ... [more ▼]

Objectives.– To assess the effects of an aerobic training for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn & Yahr stage [1] < III of PD were allocated to either 3 months of twice-weekly aerobic training (AT group; n = 8), or a control group (C group; n = 6). AT consisted in progressive stationary bike training between 50 and 70% of peak work load (PWL). Maximal incremental test on a cycloergometer was performed before and after rehabilitation. Anxiety, depression and quality of life were assessed using questionnaires. An Anova for repeated measures was used for statistical analysis. Results.– There was a significant “group by time” effect for peak work load (+21% for patients of AT group vs –9% for people of C group). Heart rate 2 minutes after test completion was also significantly decreased in AT group (post hoc analysis, P < 0.01). Patients of AT group also increased their ratio of predicted VO2 peak (+17%) but in a non-significant way. No significant changes in anxiety, depression or quality of life could be highlighted. Conclusions.– This study showed significant improvement of PWL and faster recovery in patients with PD of the AT. Significant effect on VO2 peak could need a more intense training program. [less ▲]

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See detailQue la crise perdure !
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2013), 7(6), 3

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See detailThe histopathology of idiopathic pulmonary fibrosis in West Highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man
Syrjä, P; Heikkilä, HP; Lilja-Maula, L et al

in Journal of Comparative Pathology (2013), 149(2-3), 303-313

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See detailLa virothérapie oncolytique médiée par le virus de la myxomatose
Krygier, David; Gillet, Laurent ULg; Marlier, Didier ULg

in Annales de Médecine Vétérinaire (2013), 157(1), 5-14

Le virus de la myxomatose est un poxvirus du genre Leporipoxvirus qui induit une pathologie spécifique, la myxomatose, chez le lapin européen (Oryctolagus cuniculus). Ce virus a la particularité d’être ... [more ▼]

Le virus de la myxomatose est un poxvirus du genre Leporipoxvirus qui induit une pathologie spécifique, la myxomatose, chez le lapin européen (Oryctolagus cuniculus). Ce virus a la particularité d’être non pathogène pour les autres espèces de vertébrés y compris l’homme. Le virus de la myxomatose (MYXV) présente aussi, de manière inattendue, un tropisme pour les cellules cancéreuses humaines in vitro ainsi qu’un potentiel oncolytique in vivo. La tolérance de ces cellules au MYXV est intimement liée au niveau intracellulaire d’Akt phosphorylée. Cette enzyme, est une serine/thréonine protéine kinase qui joue un rôle essentiel dans de nombreux processus cellulaires et fait partie de la voie de signalisation PI3k/Akt/mTOR (mammalian target of rapamycin), fréquemment amplifiée par l’oncogénèse. La protéine virale à répétitions ankyrines, M-T5, interagit avec Akt ce qui module le tropisme du MYXV pour les cellules tumorales humaines. Un régulateur de la croissance cellulaire et du métabolisme situé en aval d’Akt, mTOR, est spécifiquement inhibé par la rapamycine. Ainsi, l’utilisation de la rapamycine en combinaison avec le MYXV permet d’augmenter la concentration d’Akt phosphorylée, et par conséquent, d’amplifier l’oncolyse. Un meilleur contrôle chimique de la voie de signalisation d’Akt ou de la modification génétique de son génome constituera une étape décisive pour que le MYXV devienne l’un des nouveaux traitements des cancers chez l’homme [less ▲]

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See detailDynamic change of global and local information processing in Propofol-induced loss and recovery of consciousness
Monti, Martin; Lutkenoff, Evan; Rubinov, Mikail et al

in PLoS Computational Biology (2013), 9

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See detailIL-4Ralpha-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection.
Horsnell, William G. C.; Darby, Matthew G.; Hoving, Jennifer C. et al

in PLoS pathogens (2013), 9(10), 1003662

In this study, B cell function in protective T(H)2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Ralpha and IL-13; but not IL-4 ... [more ▼]

In this study, B cell function in protective T(H)2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Ralpha and IL-13; but not IL-4. Protection did not associate with parasite specific antibody responses. Re-infection of B cell-specific IL-4Ralpha(-)/(-) mice resulted in increased worm burdens compared to control mice, despite their equivalent capacity to control primary infection. Impaired protection correlated with reduced lymphocyte IL-13 production and B cell MHC class II and CD86 surface expression. Adoptive transfer of in vivo N. brasiliensis primed IL-4Ralpha expressing B cells into naive BALB/c mice, but not IL-4Ralpha or IL-13 deficient B cells, conferred protection against primary N. brasiliensis infection. This protection required MHC class II compatibility on B cells suggesting cognate interactions by B cells with CD4(+) T cells were important to co-ordinate immunity. Furthermore, the rapid nature of these protective effects by B cells suggested non-BCR mediated mechanisms, such as via Toll Like Receptors, was involved, and this was supported by transfer experiments using antigen pulsed Myd88(-)/(-) B cells. These data suggest TLR dependent antigen processing by IL-4Ralpha-responsive B cells producing IL-13 contribute significantly to CD4(+) T cell-mediated protective immunity against N. brasiliensis infection. [less ▲]

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See detailLa discussion philosophique en classe : une pratique de l'émancipation ?
Herla, Anne ULg

in Tracés (2013), 25

This paper presents a recent pedagogical practice in the field of philosophy in school: Discussion with Democratic and Philosophical Aim (DDPA). According to the author, this practice differs from a more ... [more ▼]

This paper presents a recent pedagogical practice in the field of philosophy in school: Discussion with Democratic and Philosophical Aim (DDPA). According to the author, this practice differs from a more traditional conception of philosophy teaching by upsetting three key aspects of the pedagogical relationship: the relationship to knowledge, the relationship to the master, the relationship to the group. For each of these aspects, it is to show, on the one hand how authority is questioned and reworked, and secondly how the power relations relayed by the school system are revealed and transformed. More broadly, the author argues that the DDPA in its very practice questions in a new light the nature of the philosophical act and undermines the established partitions between teacher and student, philosopher and non-philosopher, scientist and ignorant. It is in this paper to highlight the concept of emancipation - inseparably intellectual and political - that underlies such a learning device of philosophy. L’article présente une pratique pédagogique récente dans le domaine de la philosophie à l’école : la Discussion à Visée Démocratique et Philosophique. D’après l’auteure, cette pratique se distingue d’une conception plus traditionnelle de l’enseignement de la philosophie en bouleversant trois aspects essentiels de la relation pédagogique : le rapport au savoir, la relation au maître, le rapport au collectif. Pour chacun de ces aspects, il s’agit de montrer, d’une part comment l’autorité est remise en question et réélaborée, et d’autre part comment les rapports de domination relayés par le système scolaire sont dévoilés et transformés. Plus largement, l’auteure avance que la DVDP, dans sa pratique même, interroge sous un angle nouveau la nature de l’acte philosophique et ébranle les partages établis entre maître et élève, philosophe et non-philosophe, savant et ignorant. Il s’agit dans cet article de mettre en lumière la conception de l’émancipation – indissociablement intellectuelle et politique – qui sous-tend un tel dispositif d’apprentissage de la philosophie. [less ▲]

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See detailEmotional intelligence and self-efficacy among physical education teachers
Mouton, Alexandre ULg; Hansenne, Michel ULg; Delcour, Romy et al

in Journal of Teaching in Physical Education (2013), 32(4), 342-354

Research has documented a positive association between Emotional Intelligence (EI) and well-being, performance and self-efficacy. The purpose of the current study was to examine potential associations ... [more ▼]

Research has documented a positive association between Emotional Intelligence (EI) and well-being, performance and self-efficacy. The purpose of the current study was to examine potential associations between EI and self-efficacy among physical education teachers. The Trait Emotional Intelligence Questionnaire (TEIQue) and the Teacher Sense of Efficacy Scale (TSES) were administered to a sample of 119 physical education teachers. The main results show a positive association between EI and self-efficacy, and more particularly that the sociability factor of EI predicted the TSES total score. Moreover, neither age nor teaching time experience was related to EI or self-efficacy scores. These results both confirm and extend previous findings on the association between EI and self-efficacy. Suggestions are provided for specific EI training for physical education teachers. [less ▲]

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See detailGAIMS: A Reliable Non-Intrusive Gait Measuring System
Pierard, Sébastien ULg; Azrour, Samir ULg; PHAN BA, Remy ULg et al

in ERCIM News (2013), 95

Gait observation and analysis can provide invaluable information about an individual [1]. Studies that have interpreted gait using traditional imaging devices have demonstrated that it is difficult to ... [more ▼]

Gait observation and analysis can provide invaluable information about an individual [1]. Studies that have interpreted gait using traditional imaging devices have demonstrated that it is difficult to make reliable measurements with colour cameras. GAIMS, our new system resulting from a multidisciplinary project born from collaboration between engineers and neurologists, aims at developing non-intrusive and reliable tools to provide quantitative measures of gait and interpretations of the acquired data. Following a current trend in imaging, it takes advantage of imaging sensors that measure distance instead of colour. While its principles are general, GAIMS is currently used for the diagnosis of multiple sclerosis (MS) and the continued evaluation of disease progression [2]. It is the first available system to fully satisfy the clinical routine and its associated constraints. [less ▲]

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See detailModeling the Distribution of Marketable Timber Products of Private Teak (Tectona grandis L.f.) Plantations
Fonton, Noël Houédougbé; Atindogbé, Gilbert; Akossou, Arcadius Y. et al

in Open Journal of Forestry (2013), 3(4), 115-121

Management of marketable products of private plantations will not be sustainable without class girth be-ing identifiable readily. Modeling marketable products is a key to obtain good fitness between ... [more ▼]

Management of marketable products of private plantations will not be sustainable without class girth be-ing identifiable readily. Modeling marketable products is a key to obtain good fitness between observed and theoretical girth distribution. We determine the best parameter recovery method with the Weibull function for two sylvicultural regimes (coppice and high forest). Data on stand variables were collected from 1101 sample plots. The three Weibull function parameters were estimated with three parameters re-covery methods: the maximum likelihood method, the method of moments and the method of percentiles. Stepwise regression and the simultaneously re-estimated parameter using the Seemingly Unrelated Re-gression Estimation were applied to model each parameter. The results indicated that the three methods successfully predicted girth size distributions within the sample stands. The method of moments was the best one with lowest values of Reynolds error index and Kolmogorov-Smirnov statistic however the syl-vicultural regimes. The Weibull parameter distribution model developed for each of the two sylvicultural regimes was quite reliable. [less ▲]

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See detailLe syndrome des myoclonies peribuccales avec absences: a propos de 2 cas.
Bourcy, E.; Leroy, Pascal ULg; DUBRU, Jean-Marie ULg

in Revue medicale de Liege (2013), 68(10), 537-41

Perioral myoclonia with absences (POMA) was first described in 1994 by CP Panayotopoulos who identified 6 cases that did not fit with the classical syndrome of absence epilepsy in children and whose ... [more ▼]

Perioral myoclonia with absences (POMA) was first described in 1994 by CP Panayotopoulos who identified 6 cases that did not fit with the classical syndrome of absence epilepsy in children and whose predominant symptom during the absence seizure was the occurrence of myoclonia of perioral muscles. The POMA belongs to the group of generalized idiopathic epilepsies. It begins in childhood and there is a female predominance. It may be accompanied by tonic-clonic generalized seizures as well as absence status epilepticus. It has the EEG characteristics of typical absence seizures and therefore remains currently considered as such. The clinical manifestations of POMA are often misdiagnosed as focal motor seizures. This syndrome can be pharmacoresistant and is not likely to regress spontaneously. We present two clinical observations of perioral myoclonia with absences. The first case illustrates the typical electro-clinical features of this syndrome while the second illustrates its pharmacoresistance. [less ▲]

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See detailTravail sur Soi et (dé)régulation de l'intervention sociale.
Vrancken, Didier ULg; Brahy, Rachel ULg

in RHIZOME (2013), 49-50(Octobre 2013), 28-29

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See detailTechnical and clinical evaluation of the VITROS Immunodiagnostic Products 25-OH Vitamin D Total Assay - comparison with marketed automated immunoassays and a liquid chromatography - tandem mass spectrometry method
CAVALIER, Etienne ULg; ROUSSELLE, Olivier ULg; FERRANTE, Nunzio ULg et al

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 1983-1989

Background: The study was conducted to evaluate the technical and clinical performance of the VITROS ® Immunodiagnostic Products 25-OH Vitamin D Total Assay, and compare it with the performance of five ... [more ▼]

Background: The study was conducted to evaluate the technical and clinical performance of the VITROS ® Immunodiagnostic Products 25-OH Vitamin D Total Assay, and compare it with the performance of five marketed automated assays and a liquid chromatography/mass spectrometry reference method (LC-MS/MS). Methods: Three hundred patient serum samples were used to compare the correlation of the VITROS ® 25-OH Vitamin D Total Assay with both the other immunoassays and the LC-MS/MS method, using Passing-Bablok regression and Bland-Altman analyses. Concordance of the diagnosis of vitamin D status was calculated to test the agreement between the different assays. In addition, samples containing vitamin D2 were used to test the assay ’ s ability to detect the D2 form of the vitamin. Results and conclusions: These results from the VITROS ® 5-OH Vitamin D Total Assay generally correlated well with those from most of the marketed immunoassays. Cross-reactivity of the D2 form was calculated as being close to 100%. Additionally, we found substantial variability in performance amongst the various assays, which suggests the need for optimisation and recalibration of commercial methods. [less ▲]

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See detailLe grand écart des Belgo-Congolais (entretien)
Demart, Sarah ULg

in Migrations Magazine (2013), 11(Autumn),

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See detailDesign, Construction and Validation of a Guarded Hot Plate Apparatus for Thermal Conductivity Measurement of High Thickness Crop-Based Specimens
Dubois, Samuel ULg; Lebeau, Frédéric ULg

in Materials and Structures (2013)

The search for sustainability achievement in the building sector led to the use of crop-based insulation materials. Among these, raw products like plant straws bales can present elementary representative ... [more ▼]

The search for sustainability achievement in the building sector led to the use of crop-based insulation materials. Among these, raw products like plant straws bales can present elementary representative volumes (REVs) in the size order of several square centimeters. Fibers orientation may play an important role on material thermal behavior. Measuring their thermal conductivities with standard steady-state equipment can thus lead to some inaccuracies due to the necessity of resetting lower thickness samples. This paper presents a Guarded Hot Plate (GHP) apparatus designed to test high thickness samples, up to 40cm, with an accuracy of 2%. The different parts of the machine are described in details along with design process and challenges encountered. Temperature and heat flux measurements in the device represent critical design stages where optimal accuracy is needed in order to optimize the resulting global error. Regarding this, necessary numerical and experimental analyzes were conducted emphasizing on intrinsic systematic error assessment. To complete the study, some validations tests are performed on a reference material and other widely-spread polystyrene slabs. These tests take into account the optimal computation parameters resulting from the numerical analysis and the apparatus proved to be in accordance with accuracy requirements. [less ▲]

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See detailStudy of the sorption behavior of Hibscus sabdariffa anthocyanins on a macroporous resin
Beye, Cheikh ULg; Souk Tounkara, Lat; Destain, Jacqueline ULg et al

in Journal of Food Process Engineering (2013), 36(5), 579-590

The adsorption of Hibiscus sabdariffa sp. anthocyanins onto a macroporous resin was studied in laboratory experiments. The anthocyanin aqueous extracts obtained from the calyces were used in agitated ... [more ▼]

The adsorption of Hibiscus sabdariffa sp. anthocyanins onto a macroporous resin was studied in laboratory experiments. The anthocyanin aqueous extracts obtained from the calyces were used in agitated batch experiments with a macroporous resin. The adsorption kinetics and isotherms of H. sabdariffa anthocyanins on a selected macroporous resin was studied to determine the parameters that have to be optimized to recover the anthocyanins from aqueous extracts of the calyces. The adsorption kinetic experimental data were fit into a pseudo second order kinetic model, which was then used to determine several parameters such as the contact time necessary to reach equilibrium as well as the maximum adsorption capacity. The best fit for the equilibrium adsorption isotherm experimental data was obtained with the Langmuir isotherm model. Based on qualitative and quantitative interpretation of the experimental data, the resin that was tested here appeared to have good adsorption capacity for the anthocyanins even though the necessary time to reach equilibrium was particularly long. Three aspects of the desorption of anthocyanins from the resin were studied: the speed of release of the anthocyanins (desorption kinetics), the extent of the anthocyanin desorption depending on the adsorption contact time and finally, the influence of the mobile phase's characteristics [less ▲]

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See detailVertigo's Archival Impulse as Memorious Discourse
Dony, Christophe ULg

in Comics Forum (2013)

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See detailStress microbien lors du processus d’extrapolation: Approche physique et biologique
Lejeune, Annick ULg; Thonart, Philippe ULg; Delvigne, Frank ULg

in Cerevisia : Belgian Journal of Brewing and Biotechnology (2013), 38(3), 89-101

Les micro-organismes sont utilisés dans de nombreux domaines (agro-alimentaire, pharmaceutique, environnemental, énergétique,…) que ce soit pour la production de biomasse ou de métabolites particuliers ... [more ▼]

Les micro-organismes sont utilisés dans de nombreux domaines (agro-alimentaire, pharmaceutique, environnemental, énergétique,…) que ce soit pour la production de biomasse ou de métabolites particuliers. Le passage de l’échelle du laboratoire à l’échelle industrielle est souvent problématique car les micro-organismes sont sensibles aux conditions environnementales développées au sein du volume réactionnel. De plus, la perte de l’efficacité d’homogénéisation des bioréacteurs industriels entraîne des perturbations au niveau du métabolisme des cellules. C’est pourquoi il est important d’étudier les conditions hydrodynamiques développées au sein du réacteur. Cet article présente des méthodes de calcul et de modélisation de ces conditions. L’impact de l’hydrodynamique sur le métabolisme microbien peut être étudié par l’utilisation de réacteurs scale-down. Les techniques nouvelles permettant de réaliser un scale-up prennent en compte des caractères physiologiques des cellules, qui estiment l’impact des conditions environnementales sur le métabolisme microbien et donc la bonne réussite du procédé. Enfin, l’étude de Saccharomyces cerevisiae, micro-organisme de grand intérêt biotechnologique, est réalisée. [less ▲]

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See detailSedimentary development of a continuous Middle Devonian to Mississippian section from the fore-reef fringe of the Brilon Reef Complex (Rheinisches Scheifergebirge, germany)
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Cornet, Pierre et al

in Facies (2013), 59

The Brilon-reef complex is one of the biggest Devonian carbonate buildups (~80 km²) of the Rheinisches Schiefergebirge. The Burgberg section is located in the south-eastern fore-reef area of the Brilon ... [more ▼]

The Brilon-reef complex is one of the biggest Devonian carbonate buildups (~80 km²) of the Rheinisches Schiefergebirge. The Burgberg section is located in the south-eastern fore-reef area of the Brilon reef-complex and exposes a succession of strata (117 m thick) which extend from the Middle Givetian (middle varcus conodont Zone) to the Viséan (bilineatus conodont Zone). Field and microfacies observations led to the definition of nine microfacies which are integrated into a sedimentary model divided into off-reef, intermediate fore-reef and proximal fore-reef sedimentary domains (SD). The off-reef domain (SD1) is the most distal setting observed and is characterized by fine-grained sediments, dominated by pelagic biota and the local occurrence of gravity-flow deposits. The intermediate fore-reef (SD2) is characterized by a mixture of biota and sediments coming from both, deeper-water and shallow-water sources and is influenced by storm and gravity-flow currents. In this domain Renalcis mound-like structures developed locally. Finally, the proximal fore-reef (SD3) corresponds to the most proximal setting which is strongly influenced by gravity-flow currents derived from the Brilon reef-complex. The temporal evolution of microfacies in the fore-reef setting of the Burgberg section show five main palaeoenvironmental trends influenced by the onset, general development, and demise/drowning of the Brilon reef-complex. Fore-reef to off-reef lithologies and their temporal changes are from the base to the top of the section: (U1) - fine-grained sediments with large reef debris, corresponding to the initial development of the reef building upon submarine volcanoclastic deposits during the Middle Givetian (middle varcus Zone) and first export of reef debris in the fore-reef setting; (U2) - high increase of reef-derived material in the fore-reef area, corresponding to a significant progradation of the reef from the Middle Givetian to the Early Frasnian (maximum extension of the Brilon reef-complex to the south, disparilis to the falsiovalis conodont biozones); (U3) - progressive decrease of shallow-water derived material and increase of fine-grained sediments and deep-water biota into the fore-reef setting, corresponding to the stepwise withdrawal of the reef influence; from the Middle to the Late Frasnian (jamieae conodont Zone); (U4) - development of a submarine rise characterized by nodular and cephalopod-bearing limestones extending from the Late Frasnian to the Late Famennian corresponding to the demise and drowning of the Brilon reef-complex as a result of the Late Frasnian Kellwasser events (upper rhenana and triangularis conodont biozones); (U5) - significant deepening of the Burgberg area starting in the Late Famennian, directly followed by an aggrading trend marked by pelagic shales overlying the nodular limestone deposits. [less ▲]

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See detailSu Marte ci sono corride. La fantascienza spagnola durante la Restaurazione
Ceballos Viro, Alvaro ULg; Favaro, Alice

in IF. Insolito e Fantastico (2013), 14

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See detailPlant defense stimulation by natural isolates of Bacillus depends on efficient surfactin production
Cawoy, Hélène ULg; Mariutto, Martin; Henry, Guillaume et al

in Molecular Plant-Microbe Interactions [=MPMI] (2013)

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See detailMobile speckle interferometer in the long-wave infrared for aeronautical nondestructive testing in field conditions
Vandenrijt, Jean-François ULg; Thizy, Cédric ULg; Alexeenko, Igor et al

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (2013), 52(10),

Abstract We present the development of a speckle interferometer based on CO2 laser and using a thermal infrared camera based on uncooled microbolometer array. It is intended to be used for monitoring ... [more ▼]

Abstract We present the development of a speckle interferometer based on CO2 laser and using a thermal infrared camera based on uncooled microbolometer array. It is intended to be used for monitoring deformations as well as flaw detection in aeronautical composites, with a smaller sensitivity to displacement compared to equivalent system using visible lasers. Moreover the long wavelength allows working with such interferometer under out-of-laboratory conditions. A mobile system has been developed on the basis of previous laboratory developments. Then it is validated in a variety of industrial nondestructive testing applications under field working conditions. [less ▲]

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See detailInstitutions and Market Creation: Evidence from the Experience of Transition Countries
Artige, Lionel ULg; Nicolini, Rosella

in SSRN Working Paper (2013)

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See detailTransformation of the mitochondrial genome.
Larosa, Véronique ULg; Remacle, Claire ULg

in International Journal of Developmental Biology (2013), 57

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See detailNo serologic evidence for emerging Schmallenberg virus infection in dogs (Canis domesticus)
Garigliany, Mutien-Marie ULg; Desmecht, Daniel ULg; Bayrou, Calixte ULg et al

in Vector Borne & Zoonotic Diseases (2013), 13(11), 1-4

Schmallenberg virus, a novel orthobunyavirus, is spreading among ruminants, especially sheep and cattle throughout Europe. To determine the risk for domestic dog infection, we conducted a survey among ... [more ▼]

Schmallenberg virus, a novel orthobunyavirus, is spreading among ruminants, especially sheep and cattle throughout Europe. To determine the risk for domestic dog infection, we conducted a survey among cases referred to the university Companion Animal Clinic to assess possible seroconversion. No evidence of transmission to dogs was detected. [less ▲]

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See detail« Quoi de neuf pour la prise en charge de l’hypertension artérielle en 2013 ? » Nouvelles directives des Sociétés Européennes d’Hypertension et de Cardiologie.
XHIGNESSE, Patricia ULg; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2013), 68(10), 511-520

The 2013 guidelines for arterial hypertension have just been released by the European Societies of Cardiology and Hypertension. As already discussed in earlier versions, the decision to treat must be ... [more ▼]

The 2013 guidelines for arterial hypertension have just been released by the European Societies of Cardiology and Hypertension. As already discussed in earlier versions, the decision to treat must be based on the assessment of the cardiovascular risk. The value of out-of-the office blood pressure measurements to confirm the diagnosis of hypertension is underlined and the authors stress the need for a close follow up of non pharmacological therapeutic measures. A novelty, however, consists in the simplification of the blood pressure target under treatment, which must be < 140/90 mmHg in the vast majority of patients, except for octogenerians whose systolic blood pressure target should be < 150 mmHg. For resistant hypertension, renal denervation and carotid baroreceptor stimulation are proposed as new invasive modes of therapy; their clinical values, however, remain to be confirmed. [less ▲]

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See detailA fatal case of Perthes syndrome
JOBE, Jérôme ULg; Ghuysen, Alexandre ULg; Hartstein, Gary ULg et al

in Journal of Emergencies, Trauma and Shock (2013), 6(4), 296-297

Perthes syndrome, or traumatic asphyxia, is a clinical syndrome associating cervicofacial cyanosis with cutaneous petechial haemorrhages and subconjonctival bleeding resulting from severe sudden ... [more ▼]

Perthes syndrome, or traumatic asphyxia, is a clinical syndrome associating cervicofacial cyanosis with cutaneous petechial haemorrhages and subconjonctival bleeding resulting from severe sudden compressive chest trauma. Deep inspiration and a Valsalva maneuver just prior to rapid and severe chest compression, are responsible for the development of this syndrome. Current treatment is symptomatic: urgent relief of chest compression and cardiopulmonary resuscitation if needed. Outcome may be satisfactory depending on the duration and severity of compression. Prolonged thoracic compression may sometimes lead to cerebral anoxia, irreversible neurologic damage and death. We report a fatal case of Perthes syndrome resulting from an industrial accident. [less ▲]

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See detailPerformance evaluation and X-ray dose quantification for various scanning protocols of the GE eXplore 120 micro-CT
Bretin, Florian ULg; Warnock, Geoffrey; Luxen, André ULg et al

in IEEE Transactions on Nuclear Science (2013), 60(5), 3235-3241

The aim of this study was to evaluate the performance of the General Electric eXplore 120 micro-CT regarding image quality and delivered dose of several protocols. Image quality (resolution, linearity ... [more ▼]

The aim of this study was to evaluate the performance of the General Electric eXplore 120 micro-CT regarding image quality and delivered dose of several protocols. Image quality (resolution, linearity, uniformity and geometric accuracy) was assessed using the vmCT phantom developed for the GE eXplore Ultra, the QRM low contrast and the QRM Bar Pattern Phantom. All dose measurements were performed using a mobileMOSFET dose verification system and the CTDI100 and the MSAD were determined with a custom built PMMA phantom. Additionally, in vivo scans in sacrificed rats with different weights were acquired to assess dose, contrast and resolution variation due to X-ray absorption in surrounding tissue. The spatial resolution was determined as between 95 and 138 μm with a geometric accuracy of 0.1%. The system has a highly linear response to the iodine concentrations (0.937 to 30 mg/ml) for all protocols. The calculated CTDI100 ranged from 20.15 to 56.79 mGy and the MSAD from 27.98 to 77.45 mGy. The results were confirmed by in vivo scans in rats with different weights and no impact of body weight on delivered dose could be observed. However, body weight had a slight impact on image contrast and resolution. [less ▲]

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See detailIDS iSYS automated intact procollagen-1-Nterminus pro-peptide assay: method evaluation and reference intervals in adults and children
Morovat, Alireza; Catchpole, Anthony; MEURISSE, Angélique ULg et al

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 2009-2018

Background: We carried out a technical evaluation of the Immunodiagnostic Systems (IDS) automated intact procollagen- I N-terminus propeptide (PINP) assay on the iSYS platform, and established reference ... [more ▼]

Background: We carried out a technical evaluation of the Immunodiagnostic Systems (IDS) automated intact procollagen- I N-terminus propeptide (PINP) assay on the iSYS platform, and established reference intervals for PINP in both adults and children. Methods: Assay imprecision, recovery and interference were studied. Serum and plasma values were compared, and PINP stability was assessed. Using 828 specimens, IDS iSYS intact PINP and Roche E170 total PINP values were compared. Specimens from 597 adults and 485 children and adolescents were used to establish reference intervals for intact PINP. Results: The method demonstrated good recovery and acceptable imprecision. The assay was unaffected by icterus and lipaemia, but haemolysis decreased measured PINP. Serum and plasma values were comparable. There was a non-linear relation between IDS intact and Roche total PINP values. Pre- and post-menopausal women had comparable PINP values, but there was a difference between women of different age groups. Serum PINP in men showed a decline in young age up to 45 years, but remained steady thereafter. Separate reference intervals were established for four age groups in women and for two age groups in men. Data for children were partitioned into four-year age groups, and these showed PINP to be high with no major gender differences until 12 years of age. Thereafter, values in females decreased in 13–16 years age groups and further in 17–20 years age groups, whereas PINP increased in boys of 13–16 years of age with a subsequent decline at 17–20 years. Conclusions: The IDS iSYS PINP intact assay appears to be reliable. We have established gender- and age-related reference intervals for children and adults based on a relatively large healthy North European population. [less ▲]

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