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See detailIs Leopoldamys neilli (Rodentia, Muridae) a synonym of Leopoldamys herberti? A reply to Balakirev et al. (2013)
Latinne, Alice ULg; Chaval, Yannick; Waengsothorn, Surachit et al

in Zootaxa (2013), 3731(4), 589-598

Recently, Balakirev et al. (2013) presented a taxonomic revision of the genus Leopoldamys based on phylogenetic analyses. They identified five main Leopoldamys genetic lineages and suggested to rename ... [more ▼]

Recently, Balakirev et al. (2013) presented a taxonomic revision of the genus Leopoldamys based on phylogenetic analyses. They identified five main Leopoldamys genetic lineages and suggested to rename several of them. According to these authors, the genetic lineage previously thought to belong to L. edwardsi (lineage L1) should be assigned to L. revertens while L. neilli (lineage L2) should be considered as a junior synonym of L. herberti. Using molecular and morphological data from a large sampling of Leopoldamys specimens, the aim of the present study was to investigate the taxonomic status of L. herberti and L. neilli. This study reveals that, contrary to Balakirev et al.’s statement, both genetic lineages L1 and L2 occur in Nakhon Ratchasima Province, close to the type locality of L. herberti. We also show that the external measurements and color pattern of L. herberti are highly similar to those of L1 specimens but are not consistent with the morphology of L2 specimens. Therefore these results strongly suggest that L. herberti should be assigned to the genetic lineage L1. Consequently L. neilli should not be considered as a junior synonym of L. herberti and this study confirms that the appropriate name of the genetic lineage L2 is L. neilli. Moreover, as our results show that L. herberti should be assigned to the lineage L1, this name has nomenclatural priority over L. revertens, the species name suggested by Balakirev et al. (2013) for this lineage. [less ▲]

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See detailComet C/2012 S1 (Ison)
Dello Russo, N.; Vervack, R. J.; Kawakita, H. et al

in Central Bureau Electronic Telegrams (2013), 3686

CBET 3686 available at Central Bureau for Astronomical Telegrams.

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See detailMolecular epidemiology of norovirus infections in symptomatic and and asymptomatic children from Bobo Dioulasso, Burkina Faso
HUYNEN, Pascale ULg; Mauroy, Axel ULg; Martin, Caroline et al

in Journal of Clinical Virology (2013), 58

Background: Noroviruses (NoV) are a leading cause of gastroenteritis worldwide. Few epidemiologicaldata regarding the NoV strains circulating in African countries are available.Objectives: To determine ... [more ▼]

Background: Noroviruses (NoV) are a leading cause of gastroenteritis worldwide. Few epidemiologicaldata regarding the NoV strains circulating in African countries are available.Objectives: To determine the prevalence of NoV in Bobo Dioulasso (Burkina Faso) in both symptomaticand asymptomatic gastroenteritis patients.Study design: Patients both with and without gastro-intestinal disorders were selected. Clinical andepidemiological data, as well as stool samples, were collected through March to April 2011.NoV molecular detection (genogrouping and genotyping) and viral load quantification were also per-formed for all samples.Results: NoV were detected in 22.2% of the 418 collected stool samples (21.2% and 24.8% from the 293symptomatic patients (SP) and the 125 asymptomatic patients (ASP) respectively).Genogroup (G) distribution was 7.5%, 10.2% and 3.4% for GI, GII and both GI/GII respectively among SPand 12.0%, 11.2% and 1.6% for GI, GII and both GI/GII, respectively, among ASP.Average viral load values were higher in SP than in ASP for GI (p = 0.03) but not for GII.Phylogenic analysis showed a high degree of genotype diversity in SP and ASP. One recombinantGII.7/GII.6 sequence was, to the best of our knowledge, detected for the first time.Conclusions: This study enabled identification of the specific molecular epidemiology of NoV strains cir-culating in a representative country in Eastern Africa, and additionally showed that ASP could play animportant “reservoir” role. A high strain diversity was detected with a surprisingly high proportion ofNoV GI compared to the common genotypes usually reported in comparable epidemiological studies. [less ▲]

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See detailLa stimulation nerveuse répétitive : un outil diagnostique
WANG, François-Charles ULg

in Cahiers de Myologie (Les) (2013)

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See detailGabriele, dove sei? Notolette birichine intorno al 150° anniversario della nascita e al 75° della morte di Gabriele d'Annunzio
Curreri, Luciano ULg

in IlCorsaronero. Rivista salgariana di letteratura popolare (2013), 19

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See detailEvolution of the Io footprint brightness I: Far-UV observations
Bonfond, Bertrand ULg; Hess, Sébastien; Gérard, Jean-Claude ULg et al

in Planetary and Space Science (2013), 88

The Io footprint (IFP) is a set of auroral spots and an extended tail resulting from the strong interaction between Io and the Jovian magnetosphere. For the first time, we present measurements of the ... [more ▼]

The Io footprint (IFP) is a set of auroral spots and an extended tail resulting from the strong interaction between Io and the Jovian magnetosphere. For the first time, we present measurements of the brightness and precipitated power for each individual spot, using the image database gathered from 1997 to 2009 with the Hubble Space Telescope in the Far-UV domain. We show that the relative brightness of the spots varies with the System III longitude of Io. Moreover, our novel measurement method based on 3D simulations of the auroral features allows to derive the precipitated energy fluxes from images on which the emission region is observed at a slant angle. Peak values as high as 2 W/m² are observed for the main spot, probably triggering a localized and sudden heating of the atmosphere. Additionally, strong brightness differences are observed from one hemisphere to another. This result indicates that the location of Io in the plasma torus is not the only parameter to control the brightness, but that the magnetic field asymmetries also play a key role. Finally, we present new data confirming that significant variations of the spots' brightness on timescales of 2-4 minutes are ubiquitous, which suggests a relationship with intermittent double layers close to Jovian surface. [less ▲]

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See detailSick leave due to back pain in a cohort of young workers
Van Nieuwenhuyse, An; Burdorf, Lex; Crombez, Geert et al

in International Archives of Occupational and Environmental Health (2013), 86(8), 887-899

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See detailConfigurations institutionnelles de la protection de l’enfance: regards croisés de l’Afrique, de l’Europe et de l’Amérique du Nord
Wouango, Joséphine ULg; Turcotte, Daniel

in Revue Internationale Enfances Familles Générations (2013)

Cet article porte sur l’analyse de trois configurations institutionnelles de la protection de l’enfance : celle en place au Burkina Faso, en Belgique et au Québec. Pour chaque configuration, le texte ... [more ▼]

Cet article porte sur l’analyse de trois configurations institutionnelles de la protection de l’enfance : celle en place au Burkina Faso, en Belgique et au Québec. Pour chaque configuration, le texte explore les transformations qui ont marqué le passage de la prise en charge exclusive de l’enfant par la famille vers la présence accrue de l’État et la manière dont la Convention internationale des droits de l’enfant de 1989 a influencé ce passage. Il montre, au travers d’une lecture historique, que l’implication de l’État dans la protection des enfants a connu des formes et des modalités variables selon le temps et l’espace. L’approche actuelle en matière de protection de l’enfance au Nord et au Sud, approche largement inspirée de la perspective des droits, représente un défi tant pour les intervenants que pour les familles, car son application dépend à fois des ressources disponibles pour aider les enfants et les familles en difficulté, de la capacité d’action des institutions publiques et de l’efficacité des interventions. [less ▲]

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See detailRééducation du rachis cervical (principes, méthodes, indication)
Demoulin, Christophe ULg; Cagnie, Barbara; GROSDENT, Stéphanie ULg et al

in Réflexions Rhumatologiques (2013), 162(17), 14-16

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See detailAn implicit-gradient-enhanced incremental-secant mean- field homogenization scheme for elasto-plastic composites with damage
Wu, Ling ULg; Noels, Ludovic ULg; Adam, Laurent et al

in International Journal of Solids and Structures (2013), 50(24), 38433860

This paper presents an incremental-secant mean- field homogenization (MFH) procedure for composites made of elasto-plastic constituents exhibiting damage. During the damaging process of one phase, the ... [more ▼]

This paper presents an incremental-secant mean- field homogenization (MFH) procedure for composites made of elasto-plastic constituents exhibiting damage. During the damaging process of one phase, the proposed method can account for the resulting unloading of the other phase, ensuring an accurate prediction of the scheme. When strain softening of materials is involved, classical fi nite element formulations lose solution uniqueness and face the strain localization problem. To avoid this issue the model is formulated in a so-called implicit gradient-enhanced approach, with a view toward macro-scale simulations. The method is then used to predict the behavior of composites whose matrix phases exhibit strain softening, and is shown to be accurate compared to unit cell simulations and experimental results. Then the convergence of the method upon strain softening, with respect to the mesh size, is demonstrated on a notched composite ply. Finally, applications consisting in a stacking plate, successively without and with a hole, are given as illustrations of the possibility of the method to be used in a multiscale framework. [less ▲]

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See detailDevelopment of a Standard Reference Material for Metabolomics Research
Phinney, K; Ballihaut, G; Bedner, M et al

in Analytical Chemistry (2013), 85(24), 11732-11738

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology ... [more ▼]

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not towards specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research. [less ▲]

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See detailLes temporalités de la photographie de mode
Dondero, Maria Giulia ULg; Basso Fossali, Pierluigi

in Infra-mince. Revue de Photographie (2013), 8

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See detailShort-term variability in bacterial abundance, cell properties, and incorporation of leucine and thymidine in subarctic sea ice
Kaartokallio, H.; Søgaard, D.H.; Norman, L. et al

in Aquatic Microbial Ecology (2013), 71

Sea ice is a biome of immense size and provides a range of habitats for diverse microbial communities many of which are adapted to living at low temperatures and high salinities in brines. We measured ... [more ▼]

Sea ice is a biome of immense size and provides a range of habitats for diverse microbial communities many of which are adapted to living at low temperatures and high salinities in brines. We measured simultaneous incorporation of thymidine (TdR) and leucine (Leu), bacterial cell abundance and cell population properties (by flow cytometry) in subarctic sea ice in SW Greenland. Short-term temporal variability was moderate, and steep environmental gradients, typical for sea ice, were the main drivers of the variability in bacterial cell properties and activity. Low nucleic acid (LNA) bacteria, previously linked to oligotrophic ecotypes in marine habitats, were more abundant in the upper ice layers, whereas High nucleic acid (HNA) bacteria dominated in lower ice, where organic carbon was in high concentrations. Leucine incorporation was saturated at micro molar concentrations, as known from freshwater and marine biofilm systems. Leu:TdR ratios were high (up to >300) in lowermost ice layers and when they are compared to published respiration measurements these results suggest non-specific leucine incorporation. There was evidence of polyhydroxyalkanoate (PHA) containing bacteria in the sea ice, shown by brightly fluorescing intracellular inclusions after Nile Blue A staining. High leucine saturating concentrations coupled with the occurrence of PHA producing organisms further highlight the similarity of sea ice internal habitats to biofilm-like systems rather than to open-water systems. [less ▲]

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See detailBalancing the freedom of academia and security interests: can it be done?
Michel, Quentin ULg

in World ECR (2013), 27(November/december), 19

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See detailMast cells: potential positive and negative roles in tumor biology.
Marichal, Thomas ULg; Tsai, Mindy; Galli, Stephen J.

in Cancer Immunology Research (2013), 1

Mast cells are immune cells that reside in virtually all vascularized tissues. Upon activation by diverse mechanisms, mast cells can secrete a broad array of biologically active products that either are ... [more ▼]

Mast cells are immune cells that reside in virtually all vascularized tissues. Upon activation by diverse mechanisms, mast cells can secrete a broad array of biologically active products that either are stored in the cytoplasmic granules of the cells (e.g., histamine, heparin, various proteases) or are produced de novo upon cell stimulation (e.g., prostaglandins, leukotrienes, cytokines, chemokines, and growth factors). Mast cells are best known for their effector functions during anaphylaxis and acute IgE-associated allergic reactions, but they also have been implicated in a wide variety of processes that maintain health or contribute to disease. There has been particular interest in the possible roles of mast cells in tumor biology. In vitro studies have shown that mast cells have the potential to influence many aspects of tumor biology, including tumor development, tumor-induced angiogenesis, and tissue remodeling, and the shaping of adaptive immune responses to tumors. Yet, the actual contributions of mast cells to tumor biology in vivo remain controversial. Here, we review some basic features of mast cell biology with a special emphasis on those relevant to their potential roles in tumors. We discuss how using in vivo tumor models in combination with models in which mast cell function can be modulated has implicated mast cells in the regulation of host responses to tumors. Finally, we summarize data from studies of human tumors that suggest either beneficial or detrimental roles for mast cells in tumors. [less ▲]

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See detailCécile Laborde ou le républicanisme critique
Jacquemain, Marc ULg

in Politique : Revue de Débats (2013), 82

L'article présente le travail de Cécile Laborde relisant la querelle française du "hijab" à partir du républicanisme critique de Philippe Pettit. Le travail de Cécile Laborde, savant mais toujours lisible ... [more ▼]

L'article présente le travail de Cécile Laborde relisant la querelle française du "hijab" à partir du républicanisme critique de Philippe Pettit. Le travail de Cécile Laborde, savant mais toujours lisible, représente sans doute l'examen philosophique le plus poussé des travers du républicanisme à la française, utilisant judicieusement pour ce faire, les outils de la "Political Theory" anglo-saxonne. Elle examine les trois questions cruciales de la liberté religieuse, de l'égalité entre hommes et femmes et de la cohésion sociale d'une société. La thèse qui y est défendue est que le républicanisme à la française est lourdement paternaliste par sa prétention à définir, à la place des femmes ce qui constitue leur autonomie, et surtout par son déni de toute validité à la parole des femmes voilées. Cécile Laborde considère que les intuitions républicaines peuvent être dégagées de ce perfectionnisme répressif et qu'elles sont susceptibles alors de fournir une théorie normative parfaitement valide de l'autonomie. [less ▲]

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See detailEvolution of the Io Footprint Brightness II: Modeling
Hess, Sébastien; Bonfond, Bertrand ULg; Chantry, Virginie ULg et al

in Planetary and Space Science (2013), 88

The interaction of Io with the Jovian magnetosphere creates the best known and brightest satellite-controlled aurorae in our solar system. These aurorae are generated by the precipitation of electrons ... [more ▼]

The interaction of Io with the Jovian magnetosphere creates the best known and brightest satellite-controlled aurorae in our solar system. These aurorae are generated by the precipitation of electrons, which are accelerated by the Alfvén waves carrying the current between the satellite and the planet. A recent study computed the energy deposited on top of Jupiter's ionosphere due to the electron precipitation and retrieved the correct mean brightness of Io-related aurorae. The model developed in this study takes into account the acceleration mechanism and the Alfvén wave propagation effects. We use the same method to investigate the brightness variation of the different components of the Io footprint as a function of longitude. These observations are discussed in a companion paper. We identify several effects that act together to modulate the footprint brightness such as Alfvén wave reflections, magnetic mirroring of the electrons, the local interaction at Io and kinetic effects close to Jupiter. We identify the effects contributing the most to the modulation of the brightnesses of the three brightest components of the Io footprints: the main and reflected Alfvén wing spots and the transhemispheric electron spot. We show in particular that the modulation of the efficiency of the electron acceleration can be of greater importance than the modulation of the power generated at Io. We reproduce the average modulation of the spot brightnesses and present an extensive discussion of possible explanations for the observed features not reproduced by our model. [less ▲]

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See detailObesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
ESSER, Nathalie ULg; L'Homme, Laurent ULg; DE ROOVER, Arnaud ULg et al

in Diabetologia (2013), 56

Aims/hypothesis Obesity is a heterogeneous condition comprising both individuals who remain metabolically healthy (MHO) and those who develop metabolic disorders (metabolically unhealthy, MUO). Adipose ... [more ▼]

Aims/hypothesis Obesity is a heterogeneous condition comprising both individuals who remain metabolically healthy (MHO) and those who develop metabolic disorders (metabolically unhealthy, MUO). Adipose tissue is also heterogeneous in that its visceral component is more frequently associated with metabolic dysfunction than its subcutaneous component. The development of metabolic disorders is partly mediated by the NLR family pyrin domain containing-3 (NLRP3) inflammasome, which increases the secretion of inflammatory cytokines via activation of caspase-1. We compared the immunological profile and NLRP3 activity in adipose tissue between MUO and MHO individuals. Methods MHO and MUO phenotypes were defined, respectively, as the absence and the presence of the metabolic syndrome. Cellular composition and intrinsic inflammasome activity were investigated by flow cytometry, quantitative RTPCR and tissue culture studies in subcutaneous and visceral adipose tissue from 23 MUO, 21 MHO and nine lean individuals. Results We found significant differences between the three study groups, including an increased secretion of IL-1β, increased expression of IL1B and NLRP3, increased number of adipose tissue macrophages and decreased number of regulatory T cells in the visceral adipose tissue of MUO patients compared with MHO and lean participants. In macrophages derived from visceral adipose tissue, both caspase-1 activity and IL-1β levels were higher in MUO patients than in MHO patients. Furthermore, caspase-1 activity was higher in CD11c+CD206+ adipose tissue macrophages than in CD11c−CD206+ cells. Conclusions/interpretation The MUO phenotype seems to be associated with an increased activation of the NLPR3 inflammasome in macrophages infiltrating visceral adipose tissue, and a less favourable inflammatory profile compared with the MHO phenotype. [less ▲]

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See detailReview of thermal imaging systems in composite defect detection
Jorge, Iagoba; Venegas, Pablo; Vega, Laura et al

in Infrared Physics & Technology (2013), 61

Thermal imaging technologies are widely used at present in many industrial areas, while being nowadays more and more employed in R&D&i activities. This article focuses on the comparison of the results ... [more ▼]

Thermal imaging technologies are widely used at present in many industrial areas, while being nowadays more and more employed in R&D&i activities. This article focuses on the comparison of the results obtained with commercially available non-experimental infrared (IR) cameras in the field of non-destructive defect detection. One of the cameras belongs to the FLIR SC5000 series, which is a medium wavelength infrared (MWIR) camera, and the other two cameras are from the high-end ImageIR series manufactured by InfraTec GmbH: The ImageIR 8300 also belongs to the class of MWIR cameras and the ImageIR 8800 is a long wavelength infrared (LWIR) camera. The comparative study is carried out by means of inspecting three different calibrated and induced defect samples with these three cameras using similar excitation sources, so that the configuration and lay out of the tests are comparable with each other. Additionally, after every inspection, a mathematical post-processing is applied to the resulting raw thermal images in order to enhance the detection of defects present in the samples. [less ▲]

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See detailPersistent low levels of serum hCG: please do not miss phantom hCG! (pseudohypergonadotropinemia syndrome)
VALDES SOCIN, Hernan Gonzalo ULg; SYRIOS, Petros ULg; GADISSEUR, Romy ULg et al

in Acta Clinica Belgica (2013), 68(6), 465

Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or ... [more ▼]

Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophilic antibodies. This situation requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Observation: A 23 years old woman (GOPO status) consulted his gynaecologist because of persistent abdominal pain. She was diagnosed of having trophoblastic disease on the basis of persistently positive human chorionic gonadotropin (hCG) test (Roche Modular) results, in the absence of pregnancy. Persistent low levels of hCG (around 10 U/L) were detected in her plasma. The patient underwent a trial with methotrexate chemotherapy. Abdominal pain was unrelieved whereas plasma hCG was 8.9 U/L. A serology test for Chlamydia indicated persistent infection and a course of antibiotic treatment was underwent without any relief. A laparoscopic exploration ruled out any trophoblastic residue or pelvic adherences. The patient was referred to the Endocrine Unit for further pituitary and hormonal investigations. Plasma and urine samples were sent to Biology Service to exclude a false hCG positive value. While low levels of hCG were detected in serum by assay, no significant hCG was detected in the urine (0,1 U/L). When serum was treated with HBT tube for the detection of heterophilic antibodies, hCG levels were 0.98 U/L. After mouse serum treatment, hCG was not further detected in our patient, indicating the presence of phantom hCG due to the presence of human anti mouse heterophilic antibodies. Conclusions: Textbooks on obstetrics and gynecology emphasize the importance of plasma hCG testing in patients with trophoblastic diseases. The ability of laboratory measurements to guide the clinician appropriately in every circumstance is limited. Caution should be exercised when clinical findings and laboratory results are discordant. Current protocols for the diagnosis and treatment of trophoblastic disease should include a compulsory test for hCG in urine and a test for heterophilic antibodies when appropriate. In this case report, we demonstrated that phantom hCG, was caused by heterogenous human anti mouse antibodies. [less ▲]

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See detailComparison of insulin degludec with insulin glargine in insulin-naive subjects with Type 2 diabetes: a 2-year randomized, treat-to-target trial.
Begin once trial investigators; RADERMECKER, Régis ULg

in Diabetic Medicine : A Journal of the British Diabetic Association (2013)

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See detailModification of diet in renal disease versus chronic kidney disease epidemiology collaboration equation to estimate glomerular filtration rate in obese patients
BOUQUEGNEAU, Antoine ULg; Vidal-Petiot, Emanuelle; Vrtovsnik, François et al

in Nephrology Dialysis Transplantation (2013), 28(4), 122-130

Background Obesity is a recognized risk factor for both the development and progression of chronic kidney disease (CKD). Accurate estimation of glomerular filtration rate (GFR) is thus important in these ... [more ▼]

Background Obesity is a recognized risk factor for both the development and progression of chronic kidney disease (CKD). Accurate estimation of glomerular filtration rate (GFR) is thus important in these patients. We tested the performances of two creatinine-based GFR estimates, the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, in an obese population. Methods Patients with body mass index (BMI) > 30 kg/m2 were included. The reference method for measured GFR (mGFR) was 51Cr-EDTA (single-injection method, two blood samples at 120 and 240 min). Both indexed and non-indexed results were considered. Serum creatinine was measured using the IDMS-traceable compensated Jaffe method. Mean bias (eGFR–mGFR), precision (SD around the bias) and accuracy within 30% (percentage of estimations within 30% of mGFR) were calculated for both equations. Results The population included 366 patients (185 women) from two different areas. Mean age was 55 ± 14 years, and mean BMI was 36 ± 7 kg/m2. Mean mGFR was 56 ± 26 mL/min/1.73 m2 (71 ± 35 mL/min without indexation). In the total population, mean bias was +1.9 ± 14.3 and +4.6 ± 14.7 mL/min/1.73 m2 (P < 0.05), and accuracy 30% was 80 and 76% for the MDRD and CKD-EPI equations (P < 0.05), respectively. In patients with mGFR > 60 mL/min/1.73 m2, mean bias was +4.6 ± 18.4 and +9.3 ± 17.2 mL/min/1.73 m2 (P < 0.05), and accuracy 30% was 81 and 79% (NS) for the MDRD and CKD-EPI equations, respectively. Conclusions The CKD-EPI equation did not outperform the MDRD study equation in this population of obese patients [less ▲]

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See detailmTOR inhibitors in advanced breast cancer: ready for prime time?
Martin, Lesley-Ann; Andre, Fabrice; Campone, Mario et al

in Cancer Treatment Reviews (2013), 39(7), 742-52

Current therapeutic approaches for advanced breast cancer frequently target receptors mediating cell survival and proliferation, such as the estrogen receptor and/or progesterone receptor and human ... [more ▼]

Current therapeutic approaches for advanced breast cancer frequently target receptors mediating cell survival and proliferation, such as the estrogen receptor and/or progesterone receptor and human epidermal growth factor receptor-2. Although these approaches are effective for many patients, treatment resistance is common. Therefore, new treatment approaches are needed for patients with advanced breast cancer. Mammalian target of rapamycin is a highly conserved serine-threonine kinase that acts as a major signaling hub that integrates and synergizes with cellular proliferation, survival, and/or motility signals mediated by estrogen receptor, human epidermal growth factor receptor-2, and other receptor tyrosine kinases. Dysregulation of mammalian target of rapamycin signaling occurs in various tumor types, including breast cancer, and has been associated with cancer pathogenesis, disease progression, and treatment resistance. Recent clinical trials show that combined inhibition of mammalian target of rapamycin and estrogen receptor represents an effective strategy for treating hormone receptor-positive advanced breast cancer progressing on nonsteroidal aromatase inhibitor therapy, and data from ongoing trials combining mammalian target of rapamycin inhibition with human epidermal growth factor receptor-2-targeted therapy are awaited. This review focuses on the molecular rationale underlying strategies to enhance sensitivity to treatment in hormone receptor-positive and human epidermal growth factor receptor-2-positive advanced breast cancer, the clinical efficacy of such approaches, and future perspectives. [less ▲]

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See detailComparison of insulin degludec with insulin glargine in insulin-naive subjects with Type 2 diabetes: a 2-year randomized, treat-to-target trial.
BEGIN Once Long Trial Investigators; RADERMECKER, Régis ULg

in Diabetic Medicine : A Journal of the British Diabetic Association (2013)

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See detailRefractory hypercalcemia and ectopic calcitonin secretion in a malignant pancreatic neuroendocrine tumor: hypocalcemic effects on cinacalcet
VALDES SOCIN, Hernan Gonzalo ULg; rubio almanza, Matilde; LOLY, Jean-Philippe ULg et al

in Acta Clinica Belgica (2013), 68(6), 42

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

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See detailA Remark on the Poroelastic Center of Dilation
Huynen, Alexandre ULg; Detournay, Emmanuel

in Journal of Elasticity (2013)

In the original derivation due to Dougall (1897), the center of dilation is constructed from the superposition of orthogonal force dipoles. However, it can also be built by combining dislocation dipoles ... [more ▼]

In the original derivation due to Dougall (1897), the center of dilation is constructed from the superposition of orthogonal force dipoles. However, it can also be built by combining dislocation dipoles. While the two representations are equivalent in elasticity, the different nature of the force and dislocation dipoles leads to different transient behaviors in poroelasticity, when the response evolves from undrained to drained. Indeed, we show that the poroelastic solution of a center of dilation is obtained by superposing the corresponding elastic solution and either an instantaneous fluid sink or an instantaneous fluid source, depending on whether the center of dilation is treated as a singular stress or displacement discontinuity. A simple explanation to the instantaneous injection or withdrawal of a finite volume of fluid from/to the singularity is given by adopting an exploded view of the poroelastic center of dilation. The exploration of the drained, undrained and transient responses of this singularity also requires to clarify the close relationship between an instantaneous fluid source and a continuous fluid dodecapole, an object constructed by collapsing onto a point three orthogonal pairs of fluid dipoles. [less ▲]

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See detailAid for health in times of political unrest in Mali: Does donors' way of intervening allow protecting people's health?
Paul, Elisabeth ULg; Samaké, Salif; Berthé Issa Bara, Issa et al

in Health Policy & Planning (2013)

Mali has long been a leader in francophone Africa in developing systems aimed at improving aid effectiveness, especially in the health sector. But following the invasion of the Northern regions of the ... [more ▼]

Mali has long been a leader in francophone Africa in developing systems aimed at improving aid effectiveness, especially in the health sector. But following the invasion of the Northern regions of the country by terrorist groups and a coup in March 2012, donors suspended official development assistance, except for 20 support to NGOs and humanitarian assistance. They resumed aid after transfer of power to a civil government, but this was not done in a harmonized framework. This article describes and analyses how donors in the health sector reacted to the political unrest in Mali. It shows that despite its long sector-wide approach experience and international agreements to respect aid effectiveness principles, donors have not been able to intervene in view of safeguarding the investments of co-operation in the past decade, and of protecting the health systemss functioning. They reacted to the political unrest on a bilateral basis, stopped working with their ministerial partners, interrupted support to the health system which was still expected to serve populations needs and took months before organizing alternative and only partial solutions to resume aid to the health sector. The Malian example leads to a worrying conclusion: while protecting the health system's achievements and functioning for the population should be a priority, and while harmonizing donors' interventions seems the most appropriate way for that purpose, donors' management practices do not allow for reacting adequately in times of unrest. The article concludes by a number of recommendations. [less ▲]

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See detailApplication of an innovative design space optimization strategy to thedevelopment of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines
Mbinze Kindenge, Jérémie ULg; Dispas, Amandine ULg; Lebrun, Pierre ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2013), 85

The poor quality of medicines is a crucial problem of public health. Therefore, it is important to haveanalytical tools to attend decisions of the legal authorities while combating this offense. In this ... [more ▼]

The poor quality of medicines is a crucial problem of public health. Therefore, it is important to haveanalytical tools to attend decisions of the legal authorities while combating this offense. In this context,the main objective of this study was to develop generic methods able to trace, screen and determineseveral antibiotics and common associated molecules by mean of liquid chromatographic techniques.For that purpose, an innovative Design Space optimization strategy was applied, targeting 16 antibioticsand 3 beta-lactamase inhibitors. The robustness of the developed method allowed using its use in anenvironment where operational factors such as temperature are not easy to control and eased its trans-fer to Ultra High Performance Liquid Chromatography. To demonstrate its ability to quantify the targetedmolecules, the developed and transferred method was fully validated for two active ingredients com-monly used in association, sulbactam and ceftriaxone, using the accuracy profile as decision tool. Basedon this successful step, the method was then used for the quantitative determination of these two activeingredients in three pharmaceutical brands marketed in the Democratic Republic of Congo. Two out ofthe three pharmaceutical products did not comply with the specifications [less ▲]

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See detailEvaluation of Physiological Amino Acids Profiling by Tandem Mass Spectrometry
Filee, Romain; Schoos, Roland; BOEMER, François ULg

in Journal of Inherited Metabolic Disease Reports (2013)

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See detailDerrière les mots du politique. Le-pire-est-à-venir, un marqueur temporel particulier dans le discours politique en Belgique
Piet, Grégory ULg

in Mots. Les Langages du Politique (2013), 103

Que peut-on apprendre des arguments en science politique quant à leur rôle dans les discours ? S’inscrivant dans la suite des travaux sur les bifurcations et reposant sur une analyse des arguments et des ... [more ▼]

Que peut-on apprendre des arguments en science politique quant à leur rôle dans les discours ? S’inscrivant dans la suite des travaux sur les bifurcations et reposant sur une analyse des arguments et des discours politiques belges relatifs au climat, cet article interroge la fonctionnalité du marqueur le-pire-est-à-venir. Ce dernier, riche d’enseignement, s’apparente à la fois : 1) à un marqueur temporel particulier marquant le changement, 2) à un révélateur de figures politiques et 3) à un marqueur hybride dans l’énonciation des régimes de l’avenir. [less ▲]

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See detailIntroduced goldfish affect amphibians through inhibition of sexual behaviour in risky habitats: an experimental approach
Winandy, Laurane ULg; Denoël, Mathieu ULg

in PLoS ONE (2013), 8(11), 82736

The introduction of alien species is one of the major causes of current and global biodiversity loss. The introduction of fish can be a particular threat to native amphibian populations, which are ... [more ▼]

The introduction of alien species is one of the major causes of current and global biodiversity loss. The introduction of fish can be a particular threat to native amphibian populations, which are declining worldwide. One way for amphibians to persist in such altered environments is to adopt anti-predator strategies especially at the behavioural level. However, although it has been shown that avoidance behaviour may decrease the probability of being detected by a potential predator, little is known on the consequences on sexual behaviour. In this study, we tested the hypothesis that adult Alpine newts (Ichthyosaura alpestris) use shelters more often and exhibit less sexual activity in the presence of goldfish (Carassius auratus) and that they reduce sexual activity more in risky micro-habitats than in safe environments. To this end, we assessed behavioural patterns of adult newts in a replicated laboratory design. Goldfish were present in direct contact with newts in half of the tanks. Consistently throughout the study period, significantly more newts used shelter in the presence of fish than in their absence. Newts also significantly decreased their sexual activity level overall, but specially outside the shelter when they were in direct contact with fish. These results show that fish presence can affect newts in complex ways, such as through inhibition of their reproduction. Our work highlights that integrating behaviour in conservation studies is essential to understanding the patterns of coexistence and exclusion between introduced fish and amphibians. [less ▲]

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See detailProteomic Analysis of the Reproductive Organs of the Hermaphroditic Gastropod Lymnea stagnalis Exposed to Different Endocrine Disrupting Chemicals
Giusti, Arnaud ULg; Leprince, Pierre ULg; Mazzucchelli, Gabriel ULg et al

in PLoS ONE (2013), 8(11), 81086

Many studies have reported perturbations of mollusc reproduction following exposure to low concentrations (ng/L range) of endocrine disrupting chemicals (EDCs). However, the mechanisms of action of these ... [more ▼]

Many studies have reported perturbations of mollusc reproduction following exposure to low concentrations (ng/L range) of endocrine disrupting chemicals (EDCs). However, the mechanisms of action of these molecules on molluscs are still poorly understood. Investigation of the modifications of protein expression in organisms exposed to chemicals using proteomic methods can provide a broader and more comprehensive understanding of adverse impacts of pollution on organisms than conventional biochemical biomarkers (e.g., heat-shock proteins, metallothioneins, GST, EROD). In this study we have investigated the impacts of four chemicals, which exhibit different endocrine disrupting properties in vertebrates, on the proteome of the hermaphroditic freshwater pulmonate gastropod Lymnaea stagnalis after 21 days of exposure. Testosterone, tributyltin, chlordecone and cyproterone acetate were chosen as tested compounds as they can induce adverse effects on the reproduction of this snail. The 2D-DIGE method was used to identify proteins whose expression was affected by these compounds. In addition to modifying the expression of proteins involved in the structure and function of the cytoskeleton, chemicals had impacts on the expression of proteins involved in the reproduction of L. stagnalis. Exposure to 19.2 μg/L of chlordecone increased the abundance of ovipostatin, a peptide transmitted during mating through seminal fluid, which reduces oviposition in this species. The expression of yolk ferritin, the vitellogenin equivalent in L. stagnalis, was reduced after exposure to 94.2 ng Sn/L of tributyltin. The identification of yolk ferritin and the modification of its expression in snails exposed to chemicals were refined using western blot analysis. Our results showed that the tested compounds influenced the abundance of yolk ferritin in the reproductive organs. Alteration in proteins involved in reproductive pathways (e.g., ovipostatin and yolk ferritin) could constitute relevant evidence of interaction of EDCs with reproductive pathways that are under the control of the endocrine system of L. stagnalis. [less ▲]

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See detailOvergenerality Memory Style for Past and Future Events and Emotions Related in Bipolar Disorder. What are the Links with Problem Solving and Interpersonal Relationships?
Boulanger, Marie ULg; Lejeune, Aurélie; Blairy, Sylvie ULg

in Psychiatry Research (2013), 210(3), 863-870

This study investigated patients with Bipolar Disorder’s abilities to generate specific past and future events in response to positive and negative cues words as well as emotional intensity related to ... [more ▼]

This study investigated patients with Bipolar Disorder’s abilities to generate specific past and future events in response to positive and negative cues words as well as emotional intensity related to these ones. The relationships between the number of generated specific events cognitive functioning, interpersonal problems and the ability to problem solving were investigated. Nineteen BD and nineteen healthy controls completed a French version of the AMT to evaluate the past and future events recall, in function of their valence, and emotions related. Furthermore, they completed the Optional Thinking Test, the Inventory of Interpersonal Problems and the neuropsychological measures. Compared to healthy controls, BD recollected (1) fewer specific past negative events and (2) fewer future specific positive and negative events furthermore, (3) they felt more emotional intensity related to future events. These results were explained in the light of theoretical models. Finally, specific past memories deficits in BD were linked with issues in problem solving but not with levels of distress arising from interpersonal problems. In view of AM functions in everyday life, all types of deficits should be taken into consideration, and AM remediation envisaged. [less ▲]

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See detail"La révocation des libéralités pour cause d'ingratitude"
Moreau, Pierre ULg

in Revue du Notariat Belge (2013), (3079), 734-765

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See detailCompte rendu de MARIO LA CAVA, LEONARDO SCIASCIA, Lettere dal centro del mondo. 1951-1988
Curreri, Luciano ULg

in TODOMODO. Rivista internazionale di studi sciasciani. A Journal of Sciascia Studies (2013), III

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See detailDesign and evaluation of a semantic enrichment process for bibliographic databases
Lacasta, Javier; Nogueras-Iso, Javier; Falquet, Gilles et al

in Data & Knowledge Engineering (2013), 88

The limited semantics of thesauri and similar knowledge models hinder the searching and browsing possibilities of the bibliographic databases classified with this type of resources. This work proposes an ... [more ▼]

The limited semantics of thesauri and similar knowledge models hinder the searching and browsing possibilities of the bibliographic databases classified with this type of resources. This work proposes an automatic process to convert a knowledge model into a domain ontology through the alignment with DOLCE, an upper level ontology. This process is facilitated by an intermediary alignment with Wordnet, a lexical model. The process has been tested with the thesauri and bibliographic databases of Urbamet and the European Urban Knowledge Network. The Urbamet model has been used to create an atlas of urban related resources with advanced search capabilities. [less ▲]

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See detailHypovitaminose D du patient brûlé : une équation à plusieurs inconnues.
ROUSSEAU, Anne-Françoise ULg; LEDOUX, Didier ULg; DAMAS, Pierre ULg et al

in Revue Médicale de Liège (2013), 68(11), 574-578

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See detailSocialisation et intérêts politiques : nouvelles contributions empiriques
Fournier, Bernard; Grandjean, Geoffrey ULg

in Politique et Sociétés (2013), 32(2),

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See detailPrevalence and Risk Factors for Various Cardiac Diseases in a Hospital-Based Population of 3434 Horses (1994-2011)
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Journal of Veterinary Internal Medicine (2013), 27(6), 1563-70

Background: Risk factors for several cardiac diseases have been suspected in horses, but few have been statistically demonstrated in a large equine population. Objectives: To describe risk factors for ... [more ▼]

Background: Risk factors for several cardiac diseases have been suspected in horses, but few have been statistically demonstrated in a large equine population. Objectives: To describe risk factors for various cardiac diseases in a hospital-based equine population. Animals: Files of 3434 horses admitted at the internal medicine department of the Liege Equine Teaching Hospital between 1994 and 2011were reviewed and of those, 284 were categorized as suffering from moderate to severe cardiac disease. Methods: Observational study. After calculating prevalence for each cardiac disease, we tested whether breed (chi-square test) or gender, age, body weight (BW) and other cardiac diseases (logistic regressions) were risk factors (p<0.05 significant). Results: Mitral regurgitation (MR, 4.4%), atrial fibrillation (AF, 2.3%), aortic regurgitation (AR, 2.1%) and tricuspid regurgitation (TR, 1.7%) were the most common cardiac abnormalities. Determinants were male gender and increasing age for AR (OR=2.03, CI=1.07-4.94), racehorses breed and middle-age for TR (OR=4.36; CI=1.10-17.24), and high BW for AF (OR=3.54; CI=1.67-7.49). MR was the major valvular disease associated with AF, pathological ventricular arrhythmia, pulmonary regurgitation (PR) and congestive heart failure (CHF). TR was also linked to AF, PR and CHF; AR was not linked to CHF. Conclusions and clinical importance: Several previously suspected risks factors of a variety of equine cardiac diseases are statistically confirmed in the studied hospital-based population. Similar observation could be suspected in a larger randomized population and should be taken into account in health and sport’s monitoring of horses presenting predisposing factors. [less ▲]

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See detailAC vs. DC electrophoretic deposition of hydroxyapatite on titanium
Ozhukil Kollath, Vinayaraj ULg; Chen, Qiang; Closset, Raphaël ULg et al

in Journal of the European Ceramic Society (2013), 33(13-14), 27152721

In this study, electrophoretic deposition (EPD) of hydroxyapatite (HA) powder on titanium plate was performed using butanol as solvent under direct current (DC) and alternating current (AC) fields. The ... [more ▼]

In this study, electrophoretic deposition (EPD) of hydroxyapatite (HA) powder on titanium plate was performed using butanol as solvent under direct current (DC) and alternating current (AC) fields. The zeta potential of the suspensions was measured to define their stability and the charge on the particles. Coating thickness was varied by adjusting the voltage and time of deposition. Surface morphology and cross section thickness were studied using scanning electron microscopy and image analysis software. Surface crack density was calculated from the micrographs. The results showed that the samples of similar thickness have higher grain density when coated using AC as compared to DC EPD. This facile but novel test proves the capability of AC-EPD to attain denser and uniform HA coatings from non-aqueous medium. [less ▲]

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See detailRole of sea ice in global biogeochemical cycles: Emerging views and challenges
Vancoppenolle, M; Meiners, K.M.; Michel, C. et al

in Quaternary Science Reviews (2013), 79

Observations from the last decade suggest an important role of sea ice in the global biogeochemical cycles, promoted by (i) active biological and chemical processes within the sea ice; (ii) fluid and gas ... [more ▼]

Observations from the last decade suggest an important role of sea ice in the global biogeochemical cycles, promoted by (i) active biological and chemical processes within the sea ice; (ii) fluid and gas exchanges at the sea ice interface through an often permeable sea ice cover; and (iii) tight physical, biological and chemical interactions between the sea ice, the ocean and the atmosphere. Photosynthetic micro-organisms in sea ice thrive in liquid brine inclusions encased in a pure ice matrix, where they find suitable light and nutrient levels. They extend the production season, provide a winter and early spring food source, and contribute to organic carbon export to depth. Under-ice and ice edge phytoplankton blooms occur when ice retreats, favoured by increasing light, stratification, and by the release of material into the water column. In particular, the release of iron – highly concentrated in sea ice – could have large effects in the iron-limited Southern Ocean. The export of inorganic carbon transport by brine sinking below the mixed layer, calcium carbonate precipitation in sea ice, as well as active iceatmosphere carbon dioxide (CO2) fluxes, could play a central role in the marine carbon cycle. Sea ice processes could also significantly contribute to the sulphur cycle through the large production by ice algae of dimethylsulfoniopropionate (DMSP), the precursor of sulfate aerosols, which as cloud condensation nuclei have a potential cooling effect on the planet. Finally, the sea ice zone supports significant ocean-atmosphere methane (CH4) fluxes, while saline ice surfaces activate springtime atmospheric bromine chemistry, setting ground for tropospheric ozone depletion events observed near both poles. All these mechanisms are generally known, but neither precisely understood nor quantified at large scales. As polar regions are rapidly changing, understanding the large-scale polar marine biogeochemical processes and their future evolution is of high priority. Earth system models should in this context prove essential, but they currently represent sea ice as biologically and chemically inert. Paleoclimatic proxies are also relevant, in particular the sea ice proxies, inferring past sea ice conditions from glacial and marine sediment core records and providing analogs for future changes. Being highly constrained by marine biogeochemistry, sea ice proxies would not only contribute to but also benefit from a better understanding of polar marine biogeochemical cycles. [less ▲]

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See detailOn the mechanism of elasto-inertial turbulence
Dubief, Yves; Terrapon, Vincent ULg; Soria, Julio

in Physics of Fluids (2013), 25(110817), 1-16

Elasto-inertial turbulence (EIT) is a new state of turbulence found in inertial flows with polymer additives. The dynamics of turbulence generated and controlled by such additives is investigated from the ... [more ▼]

Elasto-inertial turbulence (EIT) is a new state of turbulence found in inertial flows with polymer additives. The dynamics of turbulence generated and controlled by such additives is investigated from the perspective of the coupling between polymer dynamics and flow structures. Direct numerical simulations of channel flow with Reynolds numbers ranging from 1000 to 6000 (based on the bulk and the channel height) are used to study the formation and dynamics of elastic instabilities and their effects on the flow. The flow topology of EIT is found to differ significantly from Newtonian wall-turbulence. Structures identified by positive (rotational flow topology) and negative (extensional/compressional flow topology) second invariant Qa isosurfaces of the velocity gradient are cylindrical and aligned in the spanwise direction. Polymers are significantly stretched in sheet-like regions that extend in the streamwise direction with a small upward tilt. The Qa cylindrical structures emerge from the sheets of high polymer extension, in a mechanism of energy transfer from the fluctuations of the polymer stress work to the turbulent kinetic energy. At subcritical Reynolds numbers, EIT is observed at modest Weissenberg number (Wi, ratio polymer relaxation time to viscous time scale). For supercritical Reynolds numbers, flows approach EIT at large Wi. EIT provides new insights on the nature of the asymptotic state of polymer drag reduction (maximum drag reduction), and explains the phenomenon of early turbulence, or onset of turbulence at lower Reynolds numbers than for Newtonian flows observed in some polymeric flows. [less ▲]

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See detailStrategjia e Turqisë përballë shteteve të Ballkanit Perëndimor
Lika, Liridon ULg

in Revista Shkencore Ndërkombëtare Diskutime (2013), Deuxième année(Numéro 8), 62-71

Abstract: Since coming to power of the Justice and Development Party (Adalet ve Kalkinma Partisi, AKP) in 2002, Turkey, like other emerging powers, does not hesitate to pursue a policy based on ... [more ▼]

Abstract: Since coming to power of the Justice and Development Party (Adalet ve Kalkinma Partisi, AKP) in 2002, Turkey, like other emerging powers, does not hesitate to pursue a policy based on diversification of its external relations in order to play a greater role on the international scene. The Turkish government has adopted a foreign policy so called "zero problems" with neighboring countries including the Western Balkans. Through such a policy, the Turkish authorities are making efforts to regain influence in this area, which for five centuries was part of the Ottoman Empire. However, current circumstances in the Balkans are totally different compared to those of a century ago. Therefore, proactive ambitions of Turkish foreign policy for a classic domination of the region appear to be inconsistent with the time. [less ▲]

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See detailUnsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages
L'Homme, Laurent ULg; Esser, Nathalie ULg; Riva, Laura ULg et al

in Journal of Lipid Research (2013), 54

The NLRP3 inflammasome is involved in many obesity-associated diseases such as type 2 diabetes, atherosclerosis and gouty arthritis through its ability to induce IL-1β release. The molecular link between ... [more ▼]

The NLRP3 inflammasome is involved in many obesity-associated diseases such as type 2 diabetes, atherosclerosis and gouty arthritis through its ability to induce IL-1β release. The molecular link between obesity and inflammasome activation is still unclear but free fatty acids have been proposed as one triggering event. Here we reported opposite effects of saturated fatty acids (SFAs) compared to unsaturated fatty acids (UFAs) on NLRP3 inflammasome in human monocytes/macrophages. Palmitate and stearate, both SFAs, triggered IL-1β secretion in a caspase-1/ASC/NLRP3-dependent pathway. Unlike SFAs, the UFAs oleate and linoleate did not lead to IL-1β secretion. In addition, they totally prevented the IL-1β release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers including nigericin, alum and MSU. UFAs did not affect the transcriptional effect of SFAs suggesting a specific effect on the NLRP3 activation. These results provide a new antiinflammatory mechanism of UFAs by preventing the activation of the NLRP3 inflammasome and therefore the IL-1β processing. By this way, UFAs might play a protective role in NLRP3-associated diseases. [less ▲]

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See detailBehavior of Deep Beams with Large Headed Bars
Mihaylov, Boyan ULg; Bentz, Evan; Collins, Michael

in ACI Structural Journal (2013), 110(6), 1013-1022

While anchor heads are particularly useful in the case of large bars which require significant development lengths, the ACI code provides design guidance for bars #11 or smaller. This paper presents a ... [more ▼]

While anchor heads are particularly useful in the case of large bars which require significant development lengths, the ACI code provides design guidance for bars #11 or smaller. This paper presents a test of a large deep beam reinforced with a single #18 headed bar. The behavior of the beam is evaluated in comparison to the behavior of a specimen with more conventional reinforcement of 6#8 headed bars, and to the behavior of a specimen with lap-spliced anchor hooks. Despite the extreme detailing of the specimen with a single #18 bar, the beam had the same strength as the specimen with 6#8 bars. The compressive stress in front of the anchor head reached about 1.5 times the compressive strength of the concrete and the stress in the #18 bar reached about 414 MPa (60 ksi) before the beam failed in shear along a diagonal crack away from the anchorage zone. Shear strength calculations according to Appendix A of the ACI code showed that the current strut-and-tie provisions can overestimate the shear strength of deep beams by as much as 23%. [less ▲]

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See detailEsterification of vertebrate like steroids in molluscs: A target of endocrine disruptors?
Giusti, Arnaud ULg; Joaquim-Justo, Célia ULg

in Comparative Biochemistry and Physiology. C : Comparative Pharmacology and Toxicology (2013), 158(4), 187-198

Alterations of the reproductive organs of gastropod molluscs exposed to pollutants have been reported in natural populations for more than 40 years. In some cases these impacts have been linked to ... [more ▼]

Alterations of the reproductive organs of gastropod molluscs exposed to pollutants have been reported in natural populations for more than 40 years. In some cases these impacts have been linked to exposure to endocrine disrupting chemicals (EDCs), which are known to induce adverse impacts on vertebrates, mainly by direct binding to steroid receptors or by altering hormone synthesis. Investigations on the mechanisms of action of endocrine disruptors in molluscs show that EDCs induce modifications of endogenous titres of androgens (e.g., testosterone, androstenedione) and oestrogens (e.g., 17ß-oestradiol). Alterations of the activity of enzymes related to steroid metabolism (i.e., cytochrome P450 aromatase, acyltransferases) are also often observed. In bivalves and gastropods, fatty acid esterification of steroids might constitute the major regulation of androgen and oestrogen homeostasis. The present review indicates that metabolism of steroid hormones to fatty acid esters might be a target of synthetic EDCs. Alterations of this process would impact the concentrations of free, potentially bioactive, form of steroids. [less ▲]

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See detailLe log book :un support d'apprentissage, d'accompagnement et d'évaluation des compétences professionnelles
VIERSET, Viviane ULg

in Bulletin de l'ADMEE-Europe (2013)

Développement pratico-pratique de l'usage du log book comme support d'une posture réflexive.

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See detailIdentity in schizophrenia: A study of trait self-knowledge
Boulanger, Marie ULg; Dethier, Marie ULg; Gendre, Francis et al

in Psychiatry Research (2013), 209(3), 367-374

Identity results from interlock of two systems which are a set of abstracted representations about oneself and a phenomenological self. Literature highlights identity disturbance in schizophrenia that ... [more ▼]

Identity results from interlock of two systems which are a set of abstracted representations about oneself and a phenomenological self. Literature highlights identity disturbance in schizophrenia that affects each of both systems. In the same vein, the present study investigates the stability and the quality of traits self-knowledge, a component of abstracted representations of self, in schizophrenia patients. Sixty-eight patients with schizophrenia and 68 healthy control subjects completed a short version of a personality scale (LABEL). This scale is composed of two versions (A and B), each comprising 50 adjectives that correspond to synonymous adjectives in the alternate list. Participants indicated how these adjectives described themselves and completed both versions of the scale on two separate occasions, one month apart. The findings showed that schizophrenic patients presented an unstable identity and change in identity quality compared with healthy subjects. However, this identity disturbance was weaker than expected. These results are discussed in a part of autobiographical memory disturbances in schizophrenia, illness duration and the decompensation stage. [less ▲]

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See detailPolarization radiation of vortex electrons with large orbital angular momentum
Ivanov, Igor ULg; Karlovets, Dmitry

in Physical Review. A (2013), 88(4), 043840

Vortex electrons—freely propagating electrons whose wave functions have helical wave fronts—could become a novel tool in the physics of electromagnetic radiation. They carry a nonzero intrinsic orbital ... [more ▼]

Vortex electrons—freely propagating electrons whose wave functions have helical wave fronts—could become a novel tool in the physics of electromagnetic radiation. They carry a nonzero intrinsic orbital angular momentum (OAM) ℓ with respect to the propagation axis and, for ℓ≫1, a large OAM-induced magnetic moment μ≈ℓμB (μB is the Bohr magneton), which influences the radiation of electromagnetic waves. Here, we consider in detail the OAM-induced effects caused by such electrons in two forms of polarization radiation, namely, in Cherenkov radiation and transition radiation. Thanks to the large ℓ, we can neglect quantum or spin-induced effects, which are of the order of ℏω/Ee≪1, but retain the magnetic moment contribution ℓℏω/Ee≲1, which makes the quasiclassical approach to polarization radiation applicable. We discuss the magnetic moment contribution to polarization radiation, which has never been experimentally observed, and study how its visibility depends on the kinematical parameters and the medium permittivity. In particular, it is shown that this contribution can, in principle, be detected in azimuthally nonsymmetrical problems, for example when vortex electrons obliquely cross a metallic screen (transition radiation) or move near it (diffraction radiation). We predict a left-right angular asymmetry of the transition radiation (in the plane where the charge radiation distributions would stay symmetric), which appears due to an effective interference between the charge radiation field and the magnetic moment contribution. Numerical values of this asymmetry for vortex electrons with Ee=300 keV and ℓ=100–1000 are 0.1%–1%, and we argue that this effect could be detected with existing technology. The finite conductivity of the target and frequency dispersion play crucial roles in these predictions. [less ▲]

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See detailAn unsaturated hydro-mechanical modelling of two in-situ experiments in Callovo-Oxfordian argillite
Charlier, Robert ULg; Collin, Frédéric ULg; Pardoen, Benoît ULg et al

in Engineering Geology (2013), 165

The unsaturated behaviour of Callovo-Oxfordian argillite is investigated through the modelling of 2 in-situ experiments. The first test studies the influence of ventilation in a gallery on the hydro ... [more ▼]

The unsaturated behaviour of Callovo-Oxfordian argillite is investigated through the modelling of 2 in-situ experiments. The first test studies the influence of ventilation in a gallery on the hydro-mechanical behaviour of the rock mass. The second test consists in a gas injection in the rock mass from an experimental borehole. A hydro-mechanical model is described and used in the modelling of the experiments. A review of the main hydro-mechanical parameters of argillite is presented. The numerical results highlight the need of a flow boundary condition reproducing the fluid transfers between the surroundings and the rock mass. The influence of dissolved gas on the compressibility of the liquid phase is also emphasised. [less ▲]

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See detailcompte rendu de : Giuseppe Ucciardello, Hypomnemata papiracei e lessicografia: tra Alessandria e Bisanzio
Rochette, Bruno ULg

in Bryn Mawr Classical Review [=BMCR] (2013), 2013.10.51

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See detailSpinal Cord Injuries – How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?
Neirinckx, Virginie ULg; CANTINIEAUX, Dorothée ULg; Coste, Cécile ULg et al

in Stem Cells (2013)

Since several years, adult/perinatal mesenchymal and neural crest stem cells have been widely used to help experimental animal to recover from spinal cord injury. More interestingly, recent clinical ... [more ▼]

Since several years, adult/perinatal mesenchymal and neural crest stem cells have been widely used to help experimental animal to recover from spinal cord injury. More interestingly, recent clinical trials confirmed the beneficial effect of those stem cells, which improve functional score of patients suffering from such lesions. However, a complete understanding of the mechanisms of stem cell-induced recovery is seriously lacking. Indeed, spinal cord injuries gathered a wide range of biochemical and physiopathological events (such as inflammation, oxidative stress, axonal damage, demyelination, etc) and the genuine healing process after cell transplantation is not sufficiently defined. This review aims to sum up recent data about cell therapy in spinal cord lesions using mesenchymal or recently identified neural crest stem cells, by describing precisely which physiopathological parameter is affected and the exact processes underlying the observed changes. Overall, although significant advances are acknowledged, it seems that further deep mechanistic investigation is needed for the development of optimized and efficient cell-based therapy protocols. [less ▲]

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See detailPhotosynthesis-dependent isoprene emission from leaf to planet in a global carbon-chemistry-climate model
Unger, N.; Harper, K.; Zheng, Y. et al

in Atmospheric Chemistry and Physics (2013), 13

We describe the implementation of a biochemical model of isoprene emission that depends on the electron requirement for isoprene synthesis into the Farquhar–Ball–Berry leaf model of photosynthesis and ... [more ▼]

We describe the implementation of a biochemical model of isoprene emission that depends on the electron requirement for isoprene synthesis into the Farquhar–Ball–Berry leaf model of photosynthesis and stomatal conductance that is embedded within a global chemistry-climate simulation framework. The isoprene production is calculated as a function of electron transport-limited photosynthesis, intercellular and atmospheric carbon dioxide concentration, and canopy temperature. The vegetation biophysics module computes the photosynthetic uptake of carbon dioxide coupled with the transpiration of water vapor and the isoprene emission rate at the 30 min physical integration time step of the global chemistry-climate model. In the model, the rate of carbon assimilation provides the dominant control on isoprene emission variability over canopy temperature. A control simulation representative of the present-day climatic state that uses 8 plant functional types (PFTs), prescribed phenology and generic PFT-specific isoprene emission potentials (fraction of electrons available for isoprene synthesis) reproduces 50% of the variability across different ecosystems and seasons in a global database of 28 measured campaign-average fluxes. Compared to time-varying isoprene flux measurements at 9 select sites, the model authentically captures the observed variability in the 30 min average diurnal cycle (R2 = 64–96 %) and simulates the flux magnitude to within a factor of 2. The control run yields a global isoprene source strength of 451 TgC yr−1 that increases by 30% in the artificial absence of plant water stress and by 55% for potential natural vegetation. [less ▲]

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See detailReprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato
Mariutto, Martin; Fauconnier, Marie-Laure ULg; Ongena, Marc ULg et al

in Plant Molecular Biology (2013), Online First Articles

The rhizobacterium Pseudomonas putida BTP1 stimulates induced systemic resistance (ISR) in tomato. A previous work showed that the resistance is associated in leaves with the induction of the first enzyme ... [more ▼]

The rhizobacterium Pseudomonas putida BTP1 stimulates induced systemic resistance (ISR) in tomato. A previous work showed that the resistance is associated in leaves with the induction of the first enzyme of the oxylipin pathway, the lipoxygenase (LOX), leading to a faster accumulation of its product, the free 13-hydroperoxy octadecatrienoic acid (13-HPOT), 2 days after Botrytis cinerea inoculation. In the present study, we further investigated the stimulation of the oxylipin pathway: metabolites and enzymes of the pathway were analyzed to understand the fate of the 13-HPOT in ISR. Actually the stimulation began upstream the LOX: free linolenic acid accumulated faster in P. putida BTP1-treated plants than in control. Downstream, the LOX products 13-fatty acid hydroperoxides esterified to galactolipids and phospholipids were more abundant in bacterized plants than in control before infection. These metabolites could constitute a pool that will be used after pathogen attack to produce free fungitoxic metabolites through the action of phospholipase A2, which is enhanced in bacterized plants upon infection. Enzymatic branches which can use as substrate the fatty acid hydroperoxides were differentially regulated in bacterized plants in comparison to control plants, so as to lead to the accumulation of the most fungitoxic compounds against B. cinerea. Our study, which is the first to demonstrate the accumulation of an esterified defense metabolite during rhizobacteria-mediated induced systemic resistance, showed that the oxylipin pathway is differentially regulated. It suggests that this allows the plant to prepare to a future infection, and to respond faster and in a more effective way to B. cinerea invasion. [less ▲]

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See detailNeuromodulation of chronic headaches: position statement from the European Headache Federation
Martelletti, P; Jensen, R; Antal, A et al

in Journal of Headache & Pain (2013), 14

The medical treatment of patients with chronic primary headache syndromes (chronic migraine, chronic tension-type headache, chronic cluster headache, hemicrania continua) is challenging as serious side ... [more ▼]

The medical treatment of patients with chronic primary headache syndromes (chronic migraine, chronic tension-type headache, chronic cluster headache, hemicrania continua) is challenging as serious side effects frequently complicate the course of medical treatment and some patients may be even medically intractable. When a definitive lack of responsiveness to conservative treatments is ascertained and medication overuse headache is excluded, neuromodulation options can be considered in selected cases.Here, the various invasive and non-invasive approaches, such as hypothalamic deep brain stimulation, occipital nerve stimulation, stimulation of sphenopalatine ganglion, cervical spinal cord stimulation, vagus nerve stimulation, transcranial direct current stimulation, repetitive transcranial magnetic stimulation, and transcutaneous electrical nerve stimulation are extensively published although proper RCT-based evidence is limited. The European Headache Federation herewith provides a consensus statement on the clinical use of neuromodulation in headache, based on theoretical background, clinical data, and side effect of each method. This international consensus further gives recommendations for future studies on these new approaches.In spite of a growing field of stimulation devices in headaches treatment, further controlled studies to validate, strengthen and disseminate the use of neurostimulation are clearly warranted. Consequently, until these data are available any neurostimulation device should only be used in patients with medically intractable syndromes from tertiary headache centers either as part of a valid study or have shown to be effective in such controlled studies with an acceptable side effect profile. [less ▲]

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See detailMonocatenary, branched, double-headed and bolaform surface active carbohydrate esters via photochemical thiol-ene/-yne reactions
Boyère, Cédric ULg; Broze, Guy ULg; Blecker, Christophe ULg et al

in Carbohydrate Research (2013), 380

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated ... [more ▼]

An original and versatile method for the synthesis of a range of novel mannose-based surfactants was developed via metal-free photo-induced thiol-ene/-yne “click” reactions. This light-mediated hydrothiolation reaction involving a thiolated mannose was successfully applied to terminal and internal alkenes, dienes and alkynes, leading to monocatenary, branched, double-headed and bolaform amphiphilic carbohydrate esters,respectively. A surface activity study showed that these new compounds possess valuable properties and display specific behavior at the air-water interface. It also demonstrated the greater flexibility of the thioether moiety in the spacer of the surfactants produced via a thiol-ene reaction in comparison withthe triazole heterocyclic rings in similar glucose-based surfactants synthesized elsewhere by the alkyne-azide 1,3-dipolar addition. [less ▲]

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See detailDevelopment and validation of a UHPLC−LTQ−Orbitrap MS method for non-anthocyanin flavonoids quantification in Euterpe oleracea juice
Dias, A.L.; Rozet, Eric ULg; Larondelle, Y. et al

in Analytical and Bioanalytical Chemistry (2013)

Euterpe oleracea fruits have gained much attention because of their phenolic constituents that have shown potential beneficial effects for health. The aim of this work was to identify and quantify major ... [more ▼]

Euterpe oleracea fruits have gained much attention because of their phenolic constituents that have shown potential beneficial effects for health. The aim of this work was to identify and quantify major non-anthocyanin flavonoids in fruit juice by an accurate UHPLC−LTQ−Orbitrap MS method. Fruits were processed to juice, lyophilized and defatted. The residue was then extracted with methanol by sonication and the extraction time optimized giving recovery rates > 90%. Solubilization of dried extract was realized using 40% MeOH which showed the best compromise for MS detection. For the UHPLC quantification, a HSS C18 column (1.8µm) was used with a gradient elution of methanol and water both with 0.1% formic acid. Total error and accuracy profiles were used as validation criteria. Seven compounds and their isomers were successfully separated, including the major non-anthocyanin flavonoids. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (< 15% relative bias), repeatability and intermediate precision (<13% RSD), selectivity, response function, linearity, LOD (ranged from 0.04 to 0.81 µg/mL) and LOQ (0.15 - 5.78 µg/mL) for 12 compounds were evaluated and the quantification method validated. Its applicability was demonstrated on real samples from different suppliers. Their qualitative and quantitative profiles were similar and some compounds were for the first time quantified. In addition eriodictyol was identified for the first time in this fruit along with 5 other flavonoids for which we proposed a possible structure. [less ▲]

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See detailDermal ultrastructure in collagen VI myopathy.
HERMANNS-LE THI KIM, Trinh ULg; PIERARD, Gérald ULg; Franchimont, Claudine ULg et al

in Ultrastructural Pathology (2013)

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See detailSynthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold
Nørholm, Ann-Beth; Francotte, Pierre ULg; Olsen, Lars et al

in Journal of Medicinal Chemistry (2013), 56(21), 87368745

Positive allosteric modulators of ionotropic glutamate receptors are potential compounds for treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind within the dimer interface of ... [more ▼]

Positive allosteric modulators of ionotropic glutamate receptors are potential compounds for treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind within the dimer interface of the ligand-binding domain (LBD) and stabilize the agonist-bound conformation, thereby slowing receptor desensitization and/or deactivation. Here we describe the synthesis and pharmacological testing at GluA2 of a new generation of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides. The most potent modulator 3 in complex with GluA2-LBD-L483Y-N754S was subjected to structural analysis by X-ray crystallography, and the thermodynamics of binding was studied by isothermal titration calorimetry. Compound 3 binds to GluA2-LBD-L483Y-N754S with a Kd of 0.35 μM (ΔH = −7.5 kcal/mol and −TΔS = −1.3 kcal/mol). This is the first time that submicromolar binding affinity has been achieved for this type of positive allosteric modulator. The major structural factor increasing the binding affinity of 3 seems to be interactions between the cyclopropyl group of 3 and the backbone of Phe495 and Met496. [less ▲]

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See detailImproving solar dryers' performancs using design and thermal heat storage
Bennamoun, Lyes ULg

in Food Engineering Reviews (2013)

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See detailProgramming of neuroendocrine self in the thymus and its defect in neuroendocrine autoimmunity
Geenen, Vincent ULg; Bodart, Gwennaëlle ULg; Henry, Séverine et al

in Frontiers in Neuroscience (2013), 7

During centuries after its first description by Galen, the thymus has been considered only as a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the ... [more ▼]

During centuries after its first description by Galen, the thymus has been considered only as a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the development of T (thymo-dependent) lymphocytes. A unique thymus appeared for the first time in cartilaginous fishes some 500 millions years ago, in the same time or shortly after the emergence of the adaptive (acquired) immune system. The thymus may be compared to a small brain or a computer highly specialized in the orchestration of central immunological self-tolerance. This latter was a necessity for the survival of species given the potent evolutionary pressure impacted by the high risk of autotoxicity inherent to the stochastic generation of the diversity of immune cell receptors that characterize the adaptive immune response. The new paradigm of neuroendocrine self-peptides has been proposed together with the definition of neuroendocrine self. Neuroendocrine self-peptides are not secreted by thymic epithelial cells (TECs) according to the classic model of neuroendocrine signaling, but processed for a presentation by, or in association with, the thymic major histocompatibility complex (MHC) proteins. The autoimmune regulator (AIRE) gene/protein controls the transcription of neuroendocrine genes in TECs. The presentation of self-peptides in the thymus is responsible for the clonal deletion of self-reactive T cells emerging during the random recombination of gene segments that encode variable parts of the T cell receptor for the antigen (TCR). In the same time, self-antigen presentation in the thymus also generates regulatory T (Treg) cells that are able to inhibit in the periphery self-reactive T cells having escaped negative selection in the thymus. Several arguments show that the origin of autoimmunity directed against neuroendocrine glands primarily results from a defect in the intrathymic programming of self-tolerance to neuroendocrine functions. This defect may be genetic or acquired during an enteroviral infection, for example. This novel knowledge of normal and pathologic functions of the thymus already constitutes a solid basis for the development of a novel type of tolerogenic/negative self-vaccination against type 1 diabetes (T1D). [less ▲]

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See detailLa collecte des déchets en Wallonie : organisation et performances
Gautier, Axel ULg; Reginster, Sophie ULg

in Regards Economiques (2013), (106),

En Wallonie, la collecte des déchets est fréquemment déléguée par les communes à une intercommunale ou à un collecteur privé. Par ailleurs, de plus en plus de communes utilisent des conteneurs à puce. Cet ... [more ▼]

En Wallonie, la collecte des déchets est fréquemment déléguée par les communes à une intercommunale ou à un collecteur privé. Par ailleurs, de plus en plus de communes utilisent des conteneurs à puce. Cet article compare les performances en termes de coûts de ces différentes alternatives. [less ▲]

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See detailDMFSGD: A Decentralized Matrix Factorization Algorithm for Network Distance Prediction
Liao, Yongjun ULg; Du, Wei; Geurts, Pierre ULg et al

in IEEE/ACM Transactions on Networking (2013), 21(5), 1511-1524

The knowledge of end-to-end network distances is essential to many Internet applications. As active probing of all pairwise distances is infeasible in large-scale networks, a natural idea is to measure a ... [more ▼]

The knowledge of end-to-end network distances is essential to many Internet applications. As active probing of all pairwise distances is infeasible in large-scale networks, a natural idea is to measure a few pairs and to predict the other ones without actually measuring them. This paper formulates the prediction problem as matrix completion where the unknown entries in a pairwise distance matrix constructed from a network are to be predicted. By assuming that the distance matrix has a low-rank characteristics, the problem is solvable by lowrank approximation based on matrix factorization. The new formulation circumvents the well-known drawbacks of existing approaches based on Euclidean embedding. A new algorithm, so-called Decentralized Matrix Factorization by Stochastic Gradient Descent (DMFSGD), is proposed. By letting network nodes exchange messages with each other, the algorithm is fully decentralized and only requires each node to collect and to process local measurements, with neither explicit matrix constructions nor special nodes such as landmarks and central servers. In addition, we compared comprehensively matrix factorization and Euclidean embedding to demonstrate the suitability of the former on network distance prediction. We further studied the incorporation of a robust loss function and of non-negativity constraints. Extensive experiments on various publicly-available datasets of network delays show not only the scalability and the accuracy of our approach, but also its usability in real Internet applications. [less ▲]

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See detailSynthesis of [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione: an agent for specific radiolabelling of tyrosine
Flagothier, Jessica ULg; Warnier, Corentin ULg; Dammicco, Sylvestre ULg et al

in RSC Advances (2013), 3

We developed a new [18F] prosthetic group, the [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione ([18F]FPTAD), used for its specific ligation with tyrosine-containing peptides or protein in order to ... [more ▼]

We developed a new [18F] prosthetic group, the [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione ([18F]FPTAD), used for its specific ligation with tyrosine-containing peptides or protein in order to develop a new and versatile radiolabelling technique that could provide a useful tool for new developments in PET imaging. [less ▲]

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See detailMyeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
Zouaoui Boudjeltia, Karim; Delporte, Cédric; Van Antwerpen, Pierre et al

in Mediators of Inflammation (2013), 2013

The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation ... [more ▼]

The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels. [less ▲]

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See detailThe multiple spots of the Ganymede auroral footprint
Bonfond, Bertrand ULg; Hess, Sébastien; Bagenal, Fran et al

in Geophysical Research Letters (2013), 40

The interaction between the moons and the magnetosphere of giant planets sometimes gives rise to auroral signatures in the planetary ionosphere, called the satellite footprints. So far, footprints have ... [more ▼]

The interaction between the moons and the magnetosphere of giant planets sometimes gives rise to auroral signatures in the planetary ionosphere, called the satellite footprints. So far, footprints have been detected for Io, Europa, Ganymede, and Enceladus. These footprints are usually seen as single spots. However, the Io footprint, the brightest one, displays a much more complex morphology made of at least three different spots and an extended tail. Here we present Hubble Space Telescope FUV images showing evidence for a second spot in the Ganymede footprint. The spots separation distance changes as Ganymede moves latitudinally in the plasma sheet, as is seen for the Io footprint. This indicates that the processes identified at Io are universal. Moreover, for similar Ganymede System III longitudes, the distance may also vary significantly with time, indicating changes in the plasma sheet density. We identified a rapid evolution of this distance 8 days after the detection of a volcanic outburst at Io, suggesting that such auroral observations could be used to estimate the plasma density variations at Ganymede. [less ▲]

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See detailDevelopment of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors
Francotte, Pierre ULg; Goffin, Eric ULg; Fraikin, Pierre et al

in Journal of Medicinal Chemistry (2013), 56(20), 7838-7850

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the ... [more ▼]

On the basis of the results obtained in previous series of AMPA potentiators belonging to 3,4-dihydro-2H-benzo- and 3,4-dihydro-2H-pyrido-1,2,4-thiadiazine 1,1-dioxides, the present work focuses on the design of original isosteric 3,4-dihydro-2H-thieno-1,2,4-thiadiazine 1,1-dioxides. Owing to the sulfur position, three series of compounds were developed and their activity as AMPA potentiators was characterized. In each of the developed series, potent compounds were discovered. After screening the selected active compounds on a safety in vivo test, 6-chloro-4-ethyl-3,4-dihydro-2H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide (24) appeared as the most promising compound and was further evaluated. Its effects on long-term potentiation in vivo and on AMPA-mediated noradrenaline release were measured to predict its potential cognitive enhancing properties. Finally, an object recognition test performed in mice revealed that 24 was able to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg. This study validates the interest of the isosteric replacement of the benzene or pyridine nuclei by the thiophene nucleus in the ring-fused thiadiazine dioxides class of AMPA potentiators. [less ▲]

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See detailDynamic Simulation of Large-scale Power Systems Using a Parallel Schur-complement-based Decomposition Method
Aristidou, Petros ULg; Fabozzi, Davide; Van Cutsem, Thierry ULg

in IEEE Transactions on Parallel and Distributed Systems (2013)

Power system dynamic simulations are crucial for the operation of electric power systems as they provide important information on the dynamic evolution of the system after an occurring disturbance. This ... [more ▼]

Power system dynamic simulations are crucial for the operation of electric power systems as they provide important information on the dynamic evolution of the system after an occurring disturbance. This paper proposes a robust, accurate and efficient parallel algorithm based on the Schur complement domain decomposition method. The algorithm provides numerical and computational acceleration of the procedure. Based on the shared-memory parallel programming model, a parallel implementation of the proposed algorithm is presented. The implementation is general, portable and scalable on inexpensive, shared-memory, multi-core machines. Two realistic test systems, a medium-scale and a large-scale, are used for performance evaluation of the proposed method. [less ▲]

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See detailPulsating B-type Stars in the Open Cluster NGC 884: Frequencies, Mode Identification, and Asteroseismology
Saesen, S.; Briquet, Maryline ULg; Aerts, C. et al

in Astronomical Journal (2013), 146

Recent progress in the seismic interpretation of field β Cep stars has resulted in improvements of the physical description in the stellar structure and evolution model computations of massive stars ... [more ▼]

Recent progress in the seismic interpretation of field β Cep stars has resulted in improvements of the physical description in the stellar structure and evolution model computations of massive stars. Further asteroseismic constraints can be obtained from studying ensembles of stars in a young open cluster, which all have similar age, distance, and chemical composition. We present an observational asteroseismology study based on the discovery of numerous multi-periodic and mono-periodic B stars in the open cluster NGC 884. We describe a thorough investigation of the pulsational properties of all B-type stars in the cluster. Overall, our detailed frequency analysis resulted in 115 detected frequencies in 65 stars. We found 36 mono-periodic, 16 bi-periodic, 10 tri-periodic, and 2 quadru-periodic stars and one star with nine independent frequencies. We also derived the amplitudes and phases of all detected frequencies in the U, B, V, and I filter, if available. We achieved unambiguous identifications of the mode degree for 12 of the detected frequencies in nine of the pulsators. Imposing the identified degrees and measured frequencies of the radial, dipole, and quadrupole modes of five pulsators led to a seismic cluster age estimate of log (age/yr) = 7.12-7.28 from a comparison with stellar models. Our study is a proof-of-concept for and illustrates the current status of ensemble asteroseismology of a young open cluster. [less ▲]

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See detailInference of Inhomogeneous Clouds in an Exoplanet Atmosphere
Demory, Brice-Olivier; de Wit, Julien; Lewis, Nikole et al

in Astrophysical Journal Letters (2013), 776

We present new visible and infrared observations of the hot Jupiter Kepler-7b to determine its atmospheric properties. Our analysis allows us to (1) refine Kepler-7b's relatively large geometric albedo of ... [more ▼]

We present new visible and infrared observations of the hot Jupiter Kepler-7b to determine its atmospheric properties. Our analysis allows us to (1) refine Kepler-7b's relatively large geometric albedo of Ag = 0.35 ± 0.02, (2) place upper limits on Kepler-7b thermal emission that remains undetected in both Spitzer bandpasses and (3) report a westward shift in the Kepler optical phase curve. We argue that Kepler-7b's visible flux cannot be due to thermal emission or Rayleigh scattering from H[SUB]2[/SUB] molecules. We therefore conclude that high altitude, optically reflective clouds located west from the substellar point are present in its atmosphere. We find that a silicate-based cloud composition is a possible candidate. Kepler-7b exhibits several properties that may make it particularly amenable to cloud formation in its upper atmosphere. These include a hot deep atmosphere that avoids a cloud cold trap, very low surface gravity to suppress cloud sedimentation, and a planetary equilibrium temperature in a range that allows for silicate clouds to potentially form in the visible atmosphere probed by Kepler. Our analysis does not only present evidence of optically thick clouds on Kepler-7b but also yields the first map of clouds in an exoplanet atmosphere. [less ▲]

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See detailTurbulent non-uniform flows in straight compound open-channels
Proust, S.; Fernandes, J. N.; Peltier, Yann ULg et al

in Journal of Hydraulic Research (2013)

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See detailDifferential asteroseismic study of seismic twins observed by CoRoT. Comparison of HD 175272 with HD 181420
Ozel, N.; Mosser, B.; Dupret, Marc-Antoine ULg et al

in Astronomy and Astrophysics (2013), 558

Context. The CoRoT short asteroseismic runs give us the opportunity to observe a large variety of late-type stars through their solar-like oscillations. We report the observation and modeling of the F5V ... [more ▼]

Context. The CoRoT short asteroseismic runs give us the opportunity to observe a large variety of late-type stars through their solar-like oscillations. We report the observation and modeling of the F5V star HD 175272. <BR /> Aims: Our aim is to define a method for extracting as much information as possible from a noisy oscillation spectrum. <BR /> Methods: We followed a differential approach that consists of using a well-known star as a reference to characterize another star. We used classical tools such as the envelope autocorrelation function to derive the global seismic parameters of the star. We compared HD 175272 with HD 181420 through a linear approach, because they appear to be asteroseismic twins. <BR /> Results: The comparison with the reference star enables us to substantially enhance the scientific output for HD 175272. First, we determined its global characteristics through a detailed seismic analysis of HD 181420. Second, with our differential approach, we measured the difference of mass, radius and age between HD 175272 and HD 181420. <BR /> Conclusions: We have developed a general method able to derive asteroseismic constraints on a star even in case of low-quality data. This method can be applied to stars with interesting properties but low signal-to-noise ratio oscillation spectrum, such as stars hosting an exoplanet or members of a binary system. The CoRoT space mission, launched on 2006 December 27, was developed and is operated by the CNES, with participation of the Science Programs of ESA, ESAs RSSD, Austria, Belgium, Brazil, Germany and Spain. [less ▲]

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See detailElectroencephalographic profiles for differentiation of disorders of consciousness.
Malinowska, U; Chatelle, Camille ULg; Bruno, Marie-Aurélie ULg et al

in BioMedical Engineering OnLine (2013), 12

BACKGROUND: Electroencephalography (EEG) is best suited for long-term monitoring of brain functions in patients with disorders of consciousness (DOC). Mathematical tools are needed to facilitate efficient ... [more ▼]

BACKGROUND: Electroencephalography (EEG) is best suited for long-term monitoring of brain functions in patients with disorders of consciousness (DOC). Mathematical tools are needed to facilitate efficient interpretation of long-duration sleep-wake EEG recordings. METHODS: Starting with matching pursuit (MP) decomposition, we automatically detect and parametrize sleep spindles, slow wave activity, K-complexes and alpha, beta and theta waves present in EEG recordings, and automatically construct profiles of their time evolution, relevant to the assessment of residual brain function in patients with DOC. RESULTS: Above proposed EEG profiles were computed for 32 patients diagnosed as minimally conscious state (MCS, 20 patients), vegetative state/unresponsive wakefulness syndrome (VS/UWS, 11 patients) and Locked-in Syndrome (LiS, 1 patient). Their interpretation revealed significant correlations between patients' behavioral diagnosis and: (a) occurrence of sleep EEG patterns including sleep spindles, slow wave activity and light/deep sleep cycles, (b) appearance and variability across time of alpha, beta, and theta rhythms. Discrimination between MCS and VS/UWS based upon prominent features of these profiles classified correctly 87 % of cases. CONCLUSIONS: Proposed EEG profiles offer user-independent, repeatable, comprehensive and continuous representation of relevant EEG characteristics, intended as an aid in differentiation between VS/UWS and MCS states and diagnostic prognosis. To enable further development of this methodology into clinically usable tests, we share user-friendly software for MP decomposition of EEG (http://braintech.pl/svarog) and scripts used for creation of the presented profiles (attached to this article). [less ▲]

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See detailRilouke, une cellule de surveillance des défauts génétiques dans la race blanc bleu belge
Sartelet, Arnaud ULg; Tamma, Nico ULg; Chapon, Samuel et al

in Point Vétérinaire (2013), 339

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See detailCaractériser l’environnement de travail du soignant à domicile: un enjeu pour le développement de l'Education Thérapeutique du Patient
Heyden, Isabelle ULg; Mollo, Vanina

in Activités (2013), 10(2),

A patient's therapeutic education is a permanent process which includes various organized activities that contribute towards the patient’s quality of life and help reduce long-term care costs. Whilst it ... [more ▼]

A patient's therapeutic education is a permanent process which includes various organized activities that contribute towards the patient’s quality of life and help reduce long-term care costs. Whilst it may be a solution to the increase in chronic diseases and care needs, it is nevertheless little valued financially in the Belgium home care. Home care would nevertheless appear to have developed quite significantly. It is however, difficult to grasp. In order to identify the determinants of patient education at home, sixty semi-structured interviews were carried out with managers, nurses and auxiliary nurses from twenty home care services in French-speaking areas of Belgium. Patient education at home is determined by multiple factors relating to the patient (request, involvement, capacities…), the caregiver (involvement, desire to spend time on the patient's education, professional education…), the relationship (trust, affinity, respect…), the service (organization of working time, resources…) and supranational authorities (amount and current method of funding). Some determinants are real levers through which supranational authorities and home care services can be operated. [less ▲]

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See detailJacks of all trades and masters of some
Rigo, Philippe ULg

in Naval Architect (2013)

Presentation of the EMSHIP - Erasmus Mundus Programme

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See detailFormation : il y a encore du chemin !
Vanmeerbeek, Marc ULg

in Santé Conjuguée (2013), 66

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See detailPrecise Through Wall Angular Position Sensor Compatible with Cryogenic Temperature for Space Launcher
Carapelle, Alain ULg; Martin, Nicolas ULg; Chantraine, Thierry ULg

in Sensor Letters (2013), 11(10), 1992-1995

A new rotation sensor is developed and tested for the next generation of Ariane space launchers. It aimed at measuring accurately the angular position of an admission valve (target sensitivity of 0.01° ... [more ▼]

A new rotation sensor is developed and tested for the next generation of Ariane space launchers. It aimed at measuring accurately the angular position of an admission valve (target sensitivity of 0.01°) from cryogenic (4K) to room temperature without recalibration. The measurement has to be done contactless and through pipe walls. Innovative electromagnetic application, cryogenic design and data treatment allows reaching the specifications. [less ▲]

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See detailThe histopathology of idiopathic pulmonary fibrosis in West Highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man
Syrjä, P; Heikkilä, HP; Lilja-Maula, L et al

in Journal of Comparative Pathology (2013), 149(2-3), 303-313

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See detailIl n'est jamais trop tard pour apprendre à (bien) lire ...
Bruyère, Olivier ULg

in Medi-Sphere (2013), 421

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See detailThe auditory P300-based single-switch brain–computer interface:Paradigm transition from healthy subjects to minimally consciouspatients
Pokorny, Christoph; Klobassa, Daniela; Pichler, Gerald et al

in Artificial Intelligence in Medicine (2013), 59(2), 81-90

Objective: Within this work an auditory P300 brain–computer interface based on tone stream segregation,which allows for binary decisions, was developed and evaluated.Methods and materials: Two tone ... [more ▼]

Objective: Within this work an auditory P300 brain–computer interface based on tone stream segregation,which allows for binary decisions, was developed and evaluated.Methods and materials: Two tone streams consisting of short beep tones with infrequently appearingdeviant tones at random positions were used as stimuli. This paradigm was evaluated in 10 healthysubjects and applied to 12 patients in a minimally conscious state (MCS) at clinics in Graz, Würzburg,Rome, and Liège. A stepwise linear discriminant analysis classifier with 10 × 10 cross-validation was usedto detect the presence of any P300 and to investigate attentional modulation of the P300 amplitude.Results: The results for healthy subjects were promising and most classification results were better thanrandom. In 8 of the 10 subjects, focused attention on at least one of the tone streams could be detectedon a single-trial basis. By averaging 10 data segments, classification accuracies up to 90.6 % could bereached. However, for MCS patients only a small number of classification results were above chance leveland none of the results were sufficient for communication purposes. Nevertheless, signs of consciousnesswere detected in 9 of the 12 patients, not on a single-trial basis, but after averaging of all correspondingdata segments and computing significant differences. These significant results, however, strongly variedacross sessions and conditions.Conclusion: This work shows the transition of a paradigm from healthy subjects to MCS patients. Promisingresults with healthy subjects are, however, no guarantee of good results with patients. Therefore, moreinvestigations are required before any definite conclusions about the usability of this paradigm for MCSpatients can be drawn. Nevertheless, this paradigm might offer an opportunity to support bedside clinicalassessment of MCS patients and eventually, to provide them with a means of communication. [less ▲]

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See detailA multiaxial constitutive model for concrete in the fire situation: Theoretical formulation.
Gernay, Thomas ULg; Millard, Alain; Franssen, Jean-Marc ULg

in International Journal of Solids and Structures (2013), 50(22-23), 3659-3673

This paper aims to develop a multiaxial concrete model for implementation in finite element softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a ... [more ▼]

This paper aims to develop a multiaxial concrete model for implementation in finite element softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a challenging task in structural fire engineering because of the complexity of the concrete mechanical behavior characterization and the severe requirements for the material models raised by the development of performance-based design. A fully threedimensional model is developed based on the combination of elastoplasticity and damage theories. The state of damage in concrete, assumed isotropic, is modeled by means of a fourth order damage tensor to capture the unilateral effect. The concrete model comprises a limited number of parameters that can be identified by three simple tests at ambient temperature. At high temperatures, a generic transient creep model is included to take into account explicitly the effect of transient creep strain. The numerical implementation of the concrete model in a finite element software is presented and a series of numerical simulations are conducted for validation. The concrete behavior is accurately captured in a large range of temperature and stress states. A limitation appears when modeling the concrete post-peak behavior in highly confined stress states, due to the coupling assumption between damage and plasticity, but the considered levels of triaxial confinement are unusual stress states in structural concrete. [less ▲]

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See detailLes défauts héréditaires dans la race blanc bleu belge
Sartelet, Arnaud ULg

in Point Vétérinaire (2013), 339

Cette fiche présente les tableaux cliniques et les données épidémiologiques (fondateurs, fréquences de chaque mutation) et génétiques (cartographie, gènes et mutations causales) de chaque maladie.

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See detailFifty years of crop residue management have a limited impact on soil heterotrophic respiration.
Buysse, Pauline ULg; Schnepf-Kiss, Anne-Caroline; Carnol, Monique ULg et al

in Agricultural and Forest Meteorology (2013), 180

The impacts of crop residue management on soil microbial biomass, labile carbon and heterotrophic respiration (HR) were assessed at a long-term experimental site in the Hesbaye region in Belgium. Three ... [more ▼]

The impacts of crop residue management on soil microbial biomass, labile carbon and heterotrophic respiration (HR) were assessed at a long-term experimental site in the Hesbaye region in Belgium. Three treatments, residue export (RE), farmyard manure addition (FYM) and residue restitution after harvest (RR), have been applied continuously since 1959. The soil is a Eutric Cambisol with, in 2010, significantly different total soil organic carbon contents of 4.4, 5.1 and 5.9 kg C m-2 under the RE, RR and FYM treatments, respectively. Manual field HR measurements were carried out during the 2010 and 2012 crop seasons using a dynamic closed chamber system. Microbial biomass, labile C content and metabolic diversity of soil bacteria were assessed in spring 2012. Fifty-one years after the beginning of the treatments, residue management had a limited impact on HR. Based on daily averaged values, the treatment had a significant impact (α = 10%) in 2012 but not in 2010. Based on the individual measurement dates, the treatment impact was less obvious in 2012; with the observation of a significant impact (α = 10%) on HR in only 7% and 36.8% of the measurement dates in 2010 and 2012, respectively. Labile C and microbial biomass were significantly lower in the RE treatment than in FYM and RR. Residue management had no significant effect on cold-water extracted carbon and metabolic diversity of heterotrophic soil bacteria. The limited impact of residue management on HR could be explained by (i) the relatively low amounts of recent above-ground crop inputs, (ii) the large proportion of below-ground residues and other non-exportable above-ground residues reducing the potential differences between treatments and (iii) the relatively large spatial variability of HR. In conclusion, carbon losses due to heterotrophic respiration did not differ between RE, FYM and RR treatments in the studied soil. This contrasts with the different soil organic carbon contents observed in these three treatments after fifty years of experiment. Further investigations regarding the reduction of spatial variability and the potential roles played by organic matter protection within aggregates and biochemical composition of inputs are needed. [less ▲]

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See detailStaging chronic kidney disease and estimating glomerular filtration rate: an opinion paper about the new international recommendations
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2013), 51(10), 1911-1917

Abstract: In January 2013, the international recommendations <br />of the KDIGO (for “ Kidney Disease: Improving <br />Global Outcomes ” ) to define chronic kidney disease <br />(CKD) and classify ... [more ▼]

Abstract: In January 2013, the international recommendations <br />of the KDIGO (for “ Kidney Disease: Improving <br />Global Outcomes ” ) to define chronic kidney disease <br />(CKD) and classify patients in CKD stages have been published. <br />In this opinion article, we will review and discuss <br />the most important guidelines proposed about CKD staging <br />and glomerular filtration rate (GFR) estimating. In <br />particular, we question the choice of fixed knot values <br />at 60 mL/min/1.73 m ² to define CKD. We also question <br />the strategies proposed to measure and use cystatin C <br />results. [less ▲]

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See detailMassive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites During Primary Infection
Gillet, Nicolas ULg; Gutiérrez, Gerónimo; Rodriguez, Sabrina ULg et al

in PLoS Pathogens (2013), 9(10),

Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection generally asymptomatic but can also lead to leukemia or lymphoma. These ... [more ▼]

Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection generally asymptomatic but can also lead to leukemia or lymphoma. These viruses replicate by infecting new lymphocytes (i.e. the infectious cycle) or via clonal expansion of the infected cells (mitotic cycle). The relative importance of these two cycles in viral replication varies during infection. The majority of infected clones are created early before the onset of an efficient immune response. Later on, the main replication route is mitotic expansion of pre-existing infected clones. Due to the paucity of available samples and for ethical reasons, only scarce data is available on early infection by HTLV-1. Therefore, we addressed this question in a comparative BLV model. We used high-throughput sequencing to map and quantify the insertion sites of the provirus in order to monitor the clonality of the BLV-infected cells population (i.e. the number of distinct clones and abundance of each clone). We found that BLV propagation shifts from cell neoinfection to clonal proliferation in about 2 months from inoculation. Initially, BLV proviral integration significantly favors transcribed regions of the genome. Negative selection then eliminates 97% of the clones detected at seroconversion and disfavors BLV-infected cells carrying a provirus located close to a promoter or a gene. Nevertheless, among the surviving proviruses, clone abundance positively correlates with proximity of the provirus to a transcribed region. Two opposite forces thus operate during primary infection and dictate the fate of long term clonal composition: (1) initial integration inside genes or promoters and (2) host negative selection disfavoring proviruses located next to transcribed regions. The result of this initial response will contribute to the proviral load set point value as clonal abundance will benefit from carrying a provirus in transcribed regions. [less ▲]

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See detailReview Contrastive Pragmatics. 2011. Amsterdam/ Philadelphia: John Benjamins. ISBN 978 90 272 2260 2. 182 pp.
Brems, Lieselotte ULg

in English Text Construction (2013), 2(6), 301-305

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See detailL'hyperthyroidie neonatale: clinique et prise en charge therapeutique.
Petignot, S.; NYAMUGABO MUNYERE NKANA, Kindja ULg; Socin, H. Valdes et al

in Revue medicale de Liege (2013), 68(10), 531-6

Neonatal hyperthyroidism is a rare pathology, most often the consequence of Graves' disease in the mother. Around 0.2% of pregnant women have Graves disease and 1 to 2% of newborns of mother with Graves ... [more ▼]

Neonatal hyperthyroidism is a rare pathology, most often the consequence of Graves' disease in the mother. Around 0.2% of pregnant women have Graves disease and 1 to 2% of newborns of mother with Graves' disease. This article will describe the case of 4 newborns who have been diagnosed and treated in CHU-NDB between 2007 and 2011. The second part will focus on the new recommendations about the management of these young patients from foetal period to birth. [less ▲]

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See detailANALYSE SPATIO-TEMPORELLE DES DÉGÂTS D’ÉCORCEMENT DANS LES PLANTATIONS RÉSINEUSES EN RÉGION WALLONNE
Ligot, Gauthier ULg; Lehaire, François ULg; Gheysen, Thibaut et al

in Forêt Wallonne (2013), 126

Les dégâts d’écorcement inquiètent de très nombreux gestionnaires forestiers. Depuis plus de 10 ans, des inventaires sont réalisés annuellement et des outils de diagnostic ont été développés afin d’en ... [more ▼]

Les dégâts d’écorcement inquiètent de très nombreux gestionnaires forestiers. Depuis plus de 10 ans, des inventaires sont réalisés annuellement et des outils de diagnostic ont été développés afin d’en quantifier l’ampleur en Région wallonne. L’examen de ces données met en évidence le rôle prépondérant des densités de cerfs ainsi que de la structure du paysage, de la rigueur des hivers et de la capacité d’accueil du milieu. [less ▲]

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See detailModeling of Weakly Conducting Thin Sheets in the Discontinuous Galerkin Method for Shielding Effectiveness Evaluation
Boubekeur, Mohamed; Kameni, Abelin; Modave, Axel ULg et al

in ACES Journal (2013), 28(10), 931

This paper presents a modeling of weakly conducting thin sheets in the time domain discontinuous Galerkin method. This interface condition is used to avoid the mesh of resistive sheets in order to ... [more ▼]

This paper presents a modeling of weakly conducting thin sheets in the time domain discontinuous Galerkin method. This interface condition is used to avoid the mesh of resistive sheets in order to evaluate the shielding effectiveness in high frequency electromagnetic compatibility problems. This condition is valid when the thickness of the sheet is smaller than the skin depth. This approach is validated by a comparison with an analytical solution. A 1D two sheets example, 2D and 3D cavities are treated to illustrate the efficiency of the condition. [less ▲]

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See detailEffects of 3 months of aerobic training on fitness of Parkinson's disease patients
Demonceau, Marie ULg; rodriguez de la Cruz, carlos; kalimira, kinja et al

in Annals of Physical and Rehabilitation Medicine (2013)

Objectives.– To assess the effects of an aerobic training for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn & Yahr stage [1] < III of PD were allocated to either 3 months of ... [more ▼]

Objectives.– To assess the effects of an aerobic training for people with Parkinson's disease (PD). Methods.– Fourteen patients with Hoehn & Yahr stage [1] < III of PD were allocated to either 3 months of twice-weekly aerobic training (AT group; n = 8), or a control group (C group; n = 6). AT consisted in progressive stationary bike training between 50 and 70% of peak work load (PWL). Maximal incremental test on a cycloergometer was performed before and after rehabilitation. Anxiety, depression and quality of life were assessed using questionnaires. An Anova for repeated measures was used for statistical analysis. Results.– There was a significant “group by time” effect for peak work load (+21% for patients of AT group vs –9% for people of C group). Heart rate 2 minutes after test completion was also significantly decreased in AT group (post hoc analysis, P < 0.01). Patients of AT group also increased their ratio of predicted VO2 peak (+17%) but in a non-significant way. No significant changes in anxiety, depression or quality of life could be highlighted. Conclusions.– This study showed significant improvement of PWL and faster recovery in patients with PD of the AT. Significant effect on VO2 peak could need a more intense training program. [less ▲]

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See detailPolarization holography for vortex retarders recording
Piron, Pierre ULg; Blain, Pascal ULg; Mawet, Dimitri et al

in Applied Optics (2013), 52(28), 7040-7048

We present an original static recording method for vortex retarders (VRs) made from liquid crystal polymers (LCPs) using the superimposition of several polarized beams. VRs are birefringent plates ... [more ▼]

We present an original static recording method for vortex retarders (VRs) made from liquid crystal polymers (LCPs) using the superimposition of several polarized beams. VRs are birefringent plates characterized by a rotation of their fast axis about their center. The new method is based on polarization holography and photo-orientable LCP. Combining several polarized beams induces the polarization patterns required for the recording process of VRs without mechanical action. A mathematical description of the method, the outcomes of the numerical simulations, and the first experimental results are presented. [less ▲]

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See detailLes matrices métalliques et céramiques : de nouveaux matériaux composites
Montrieux, Henri-Michel ULg; Lecomte-Beckers, Jacqueline ULg; Mertens, Anne ULg

in Plus Composites (2013), article n°3

Le présent article décrit différentes limitations des matériaux composites à matrice polymère. Outre l’amélioration de la formulation des résines, une des alternatives qui se présente est d’employer une ... [more ▼]

Le présent article décrit différentes limitations des matériaux composites à matrice polymère. Outre l’amélioration de la formulation des résines, une des alternatives qui se présente est d’employer une matrice métallique ou céramique. Certains de ces matériaux nouveaux sont toujours au stade du développement. Il s’agit par exemple des composites pour applications structurales avec une matrice légère en aluminium ou en magnésium pour lesquels les rapports rigidité-poids et résistance-poids sont élevés. La résilience est aussi améliorée par rapport aux matrices classiques simplement renforcées. D’autres composites à matrice métallique tels que les cermets sont industrialisés comme outils de coupe. Des composites à matrice céramique comme le carbone-carbone ou le carbone-SiC peuvent être industrialisés et présentent une durabilité et une température d’utilisation maximale exceptionnelle. Pour terminer, l’article fournit quelques informations sur les techniques nouvelles de mise à forme des matériaux composites telles que le friction stir processing et l’additive manufacturing. [less ▲]

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See detailQue la crise perdure !
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2013), 7(6), 3

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