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See detailKeping Tabs on Dioxins
Focant, Jean-François ULg

in The Analytical Scientist (2014), 15

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See detailCardiovascular imaging.
Lancellotti, Patrizio ULg; Habib, Gilbert; Negila, Danilo et al

in European heart journal (2014), 35(18), 1161-2

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See detailCognitive and neuroimaging evidence of impaired interaction between Self and memory in Alzheimer’s disease
Genon, Sarah ULg; Bahri, Mohamed Ali ULg; Collette, Fabienne ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 51

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect ... [more ▼]

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect (SRRE)). The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer’s disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for self-relevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes-no recognition phases were administrated in an MRI scanner. Brain activation as measured by fMRI was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs. recollective experience). The behavioural results revealed that the SRE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of self-related information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgments. However, the variable and limited memory advantage for self-related information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgments, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC. [less ▲]

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See detailSnijders’ correction of Infit and Outfit indexes with estimated ability level : an analysis with the Rasch model
Magis, David ULg; Béland, Sébastien; Raîche, Gilles

in Journal of Applied Measurement (2014), 15

The Infit mean square W and the Outfit mean square U are commonly used person fit indexes under Rasch measurement. However, they suffer from two major weaknesses. First, their asymptotic distribution is ... [more ▼]

The Infit mean square W and the Outfit mean square U are commonly used person fit indexes under Rasch measurement. However, they suffer from two major weaknesses. First, their asymptotic distribution is usually derived by assuming that the true ability levels are known. Second, such distributions are even not clearly stated for indexes U and W. Both issues can seriously affect the selection of an appropriate cut-score for person fit identification. Snijders (2001) proposed a general approach to correct some person fit indexes when specific ability estimators are used. The purpose of this paper is to adapt this approach to U and W indexes. First, a brief sketch of the methodology and its application to U and W is proposed. Then, the corrected indexes are compared to their classical versions through a simulation study. The suggested correction yields controlled Type I errors against both conservatism and inflation, while the power to detect specific misfitting response patterns gets significantly increased. [less ▲]

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See detailCriteria and tools for objectively analysing the vocal accuracy of a popular song
Larrouy, Pauline ULg; Morsomme, Dominique ULg

in Logopedics, Phoniatrics, Vocology (2014), 39

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt ... [more ▼]

This study aims to validate our method for measuring accuracy in a melodic context. We analysed the popular song “Happy Birthday” sung by 63 occasional and 14 professional singers thanks to AudioSculpt and OpenMusic (Ircam, Paris, France). In terms of evaluation of the pitch interval deviation, we replicated the profile of occasional singers described in the literature (the slower the performance, the more accurate it is). Our results also confirm that the professional singers sing more accurately than occasional singers but not when a Western operatic singing technique is involved. These results support the relevance of our method for analysing vocal accuracy of occasional and professional singers and led us to discuss adaptations to be implemented for analysing the accuracy of operatic voices. [less ▲]

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See detailValidation d’un test d’inhibition auprès d’enfants présentant un trouble déficitaire de l’attention avec/sans hyperactivité
Catale, Corinne ULg; Lejeune, Caroline ULg; Schmitz, Xavier ULg et al

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2014), 46(1), 66-72

The objective of this study was to assess the development of inhibition in 5-11 years old children with the “Stroop fruit” task (see Archibald & Kerns, 1999; Catale & Meulemans, 2005) and to examine the ... [more ▼]

The objective of this study was to assess the development of inhibition in 5-11 years old children with the “Stroop fruit” task (see Archibald & Kerns, 1999; Catale & Meulemans, 2005) and to examine the clinical value of this tool. 346 French-speaking children without any developmental disorders or learning disabilities were included in this study. A clinical group of 25 children with attention deficit and hyperactivity disorder was also assessed with this task. Developmental analyses on age groups show an enhancement of performance in the interference condition between 5 and 8 years old. Furthermore, results also show that the clinical group performed significantly less accurately that the control group for the interference condition, which confirms the clinical interest of this tool. [less ▲]

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See detailSECOND ORDER SYMMETRIES OF THE CONFORMAL LAPLACIAN
Michel, Jean-Philippe ULg; Radoux, Fabian ULg; Silhan, Josef

in Symmetry, Integrability and Geometry: Methods and Applications [=SIGMA] (2014), 10(016), 26

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by ... [more ▼]

Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by differential operators of second order. They are constructed from conformal Killing 2-tensors satisfying a natural and conformally invariant condition. As a consequence, we get also the classification of the second order symmetries of the conformal Laplacian. Our results generalize the ones of Eastwood and Carter, which hold on conformally flat and Einstein manifolds respectively. We illustrate our results on two families of examples in dimension three. [less ▲]

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See detailMicrostructure and Mechanical Properties of a Mixed Si-Al TRIP-Assisted Steel Subjected to Continuous Galvanizing Heat Treatments
Mertens, Anne ULg; Bellhouse, Erika M.; McDermid, Joseph R.

in Materials Science & Engineering : A (2014), 608

Heat treatments with an isothermal bainitic transformation temperature of 465°C compatible with the continuous galvanizing process were performed on a 0.2C-1.5Mn-1.0Si-0.5Al (wt%) TRIP-assisted steel. The ... [more ▼]

Heat treatments with an isothermal bainitic transformation temperature of 465°C compatible with the continuous galvanizing process were performed on a 0.2C-1.5Mn-1.0Si-0.5Al (wt%) TRIP-assisted steel. The effect of intercritical annealing temperature and isothermal bainitic transformation (IBT) time at 465C on mechanical properties and microstructure were determined. The best combination of strength and ductility was obtained for the lower intercritical annealing temperature of 750°C for an isothermal bainitic transformation time of 90 s at 465°C. However, after intercritical annealing at a higher temperature of 797°C, optimum mechanical properties were obtained for a shorter isothermal bainitic transformation time of 60 s at 465°C, likely due to the lower C content of the intercritical austenite bringing about faster transformation kinetics. It was concluded that varying the intercritical temperature and IBT time can play an important role in the development of a suitable process window to obtain the desired mechanical properties in low alloy TRIP-assisted steels given the constraints associated with the continuous galvanizing process. [less ▲]

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See detailThe influence of equivalent contact area computation in extended node to surface contact elements
Wautelet, Gaëtan ULg; Ponthot, Jean-Philippe ULg

in Key Engineering Materials [=KEM] (2014), 618

This article aims at extending the node to surface formulation for contact problems with an area regularization as proposed by [1]. For that purpose, two methods are proposed to compute the equivalent ... [more ▼]

This article aims at extending the node to surface formulation for contact problems with an area regularization as proposed by [1]. For that purpose, two methods are proposed to compute the equivalent contact area attributed to each slave node. The first method, which is based on a geometrical approach through force equivalence, is an original extension of the one proposed in [1] for two-dimensional contact problems, i.e. plane stress and plane strain state, to the axisymmetric modelling context. The second method relies on an energy consistent way obtained through the virtual work principle and the same expression for the equivalent contact area as the one originally cited in [2] is then recovered. First, the node to surface strategy with area regularization is introduced and the aforementioned methods for the equivalent contact area are presented in detail and compared. Afterwards a consistent linearization technique is applied to achieve a quadratic convergence rate in the Newton Raphson iterative procedure used to solve the non-linear equilibrium equations of the underlying finite element model. Finally, two axisymmetric numerical examples are provided in order to compare the aforementioned equivalent contact area evaluations and to demonstrate the performance and the robustness of the consistent approach especially in the neighbourhood the revolution axis. [less ▲]

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See detailInfluence of cement and aggregate type on thaumasite formation in concrete
Nielsen, peter; Sven, Nicolai; Darimont, Anne ULg et al

in Cement & Concrete Composites (2014), 53

In this study the influence of binder type on the formation of thaumasite in mortars made with expanded clay lightweight aggregates (LWA) was examined. For this purpose mortar prisms (20x20x160mm) were ... [more ▼]

In this study the influence of binder type on the formation of thaumasite in mortars made with expanded clay lightweight aggregates (LWA) was examined. For this purpose mortar prisms (20x20x160mm) were made with different binders and expanded clay lightweight aggregate or quartz sand, which after 28 days of curing in water were exposed to a 2.37 % Na2SO4 solution. The length and weight change of the prisms was recorded in triplicate as a function of time of exposure to dry-wet cycles in the sulphate solution or deionised water, at a temperature of 5 ± 1°C. The influence of the binder type on the expansion of the prisms in the 2.37 % Na2SO4 solution with dry and wet cycling can be ordered from strong to weak as follows: (1) CEM I + limestone filler, (2) CEM I, (3) CEM I + fly ash, (4) CEM III. The use of specific cements or cement blends can clearly inhibit the formation of thaumasite (and/or ettringite). The influence of the aggregate type (quartz versus LWA) on the sulphate reaction is more difficult to determine because the porosity of LWA can accommodate the growing sulphate crystals. All the mortar prisms made with quartz aggregate were bent or broken after 21 to 24 weeks exposure to the sulphate solution, while most mortar prisms made with expanded clay aggregate were still intact. The only exception being the mortar prisms containing limestone filler. The latter disintegrated between 24 and 34 weeks of exposure to the sulphate solution. The expansion of the prisms made with CEM I and CEM I + fly ash levelled off between 50 and 100 weeks of exposure to the sulphate solution. The prisms made with CEM III showed minimal expansion (≤ 0.1 %) after 3 years of exposure. The prisms exposed to demineralised water showed no or minimal expansion. The presence and mineralogy of secondary sulphate phases in the mortars was checked by XRD analysis and SEM-EDS analysis of (degraded) mortar prisms. In most cases a solid solution of ettringite-thaumasite was observed. Based on the composition, treatment and expansion of the different mortar prisms, key factors controlling the formation of thaumasite or a solid solution of thaumasite-ettringite are discussed. [less ▲]

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See detailQuantification of HTLV-1 Clonality and TCR Diversity.
Laydon, Daniel J.; Melamed, Anat; Sim, Aaron et al

in PLoS computational biology (2014), 10(6), 1003646

Estimation of immunological and microbiological diversity is vital to our understanding of infection and the immune response. For instance, what is the diversity of the T cell repertoire? These questions ... [more ▼]

Estimation of immunological and microbiological diversity is vital to our understanding of infection and the immune response. For instance, what is the diversity of the T cell repertoire? These questions are partially addressed by high-throughput sequencing techniques that enable identification of immunological and microbiological "species" in a sample. Estimators of the number of unseen species are needed to estimate population diversity from sample diversity. Here we test five widely used non-parametric estimators, and develop and validate a novel method, DivE, to estimate species richness and distribution. We used three independent datasets: (i) viral populations from subjects infected with human T-lymphotropic virus type 1; (ii) T cell antigen receptor clonotype repertoires; and (iii) microbial data from infant faecal samples. When applied to datasets with rarefaction curves that did not plateau, existing estimators systematically increased with sample size. In contrast, DivE consistently and accurately estimated diversity for all datasets. We identify conditions that limit the application of DivE. We also show that DivE can be used to accurately estimate the underlying population frequency distribution. We have developed a novel method that is significantly more accurate than commonly used biodiversity estimators in microbiological and immunological populations. [less ▲]

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See detailNormal reference ranges for echocardiography: do we really need more?
Lancellotti, Patrizio ULg

in European heart journal cardiovascular Imaging (2014), 15(3), 253-4

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See detailLes lipopeptides d’origine microbienne, des agents de biocontrôle aux multiples facettes
Jacques, P.; Deravel, J.; Coutte, F. et al

in Phytoma (2014), 672

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See detailExercise Echocardiography in Asymptomatic Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction.
Henri, Christine; Lancellotti, Patrizio ULg

in Journal of cardiovascular ultrasound (2014), 22(1), 1-5

The management of asymptomatic patients with severe aortic stenosis (AS) remains controversial. Recent series reported that early aortic valve replacement might be associated with improved clinical ... [more ▼]

The management of asymptomatic patients with severe aortic stenosis (AS) remains controversial. Recent series reported that early aortic valve replacement might be associated with improved clinical outcomes. However, the risk-benefit ratio should be carefully evaluated and early surgery only be proposed to a subset of asymptomatic patients considered at higher risk. Exercise echocardiography can help unmask symptomatic patients combined with assessment of the hemodynamic consequences of AS. Recent studies have demonstrated that exercise echocardiography can provide incremental prognostic value to identify patients who may benefit most from early surgery. In "truly" asymptomatic patients, an increase in mean aortic gradient >/= 18-20 mmHg, a limited left ventricular contractile reserve or a pulmonary hypertension during exercise are predictive parameters of adverse cardiac events. Exercise echocardiography is low-cost, safe and available in many referral centers, and does not expose patients to radiation. The purpose of this article is to describe the role of exercise testing and echocardiography in the management of asymptomatic patients with severe AS and preserved left ventricular ejection fraction. [less ▲]

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See detailOptimization of a formic/acetic acid delignification treatment on beech wood and its influence on the structural characteristics of the extracted lignins
Simon, Mathilde; Brostaux, Yves ULg; Vanderghem, Caroline ULg et al

in Journal of Chemical Technology & Biotechnology (2014), 89(1), 128-136

Background In order to replace petrochemicals by bio-based lignin products in a lot of high value-added applications, a formic/acetic acid treatment was adapted to beech wood (Fagus sylvatica L.) for ... [more ▼]

Background In order to replace petrochemicals by bio-based lignin products in a lot of high value-added applications, a formic/acetic acid treatment was adapted to beech wood (Fagus sylvatica L.) for lignin extraction. Results Beech wood particles were delignified at atmospheric pressure by a formic acid/acetic acid/water mixture. Cooking time and temperature were optimized for delignification, pulp yield and 2-furfural concentration. Response surface design analysis revealed that delignification yield increased with cooking time and temperature. Conclusion The multi-criteria optimization of delignification was used to find the ideal cooking conditions (5h07 min, 104.2°C) which could be satisfactory for the maximization of delignification (70.5%) and pulp yield (58.7%) and, to a lesser extent, for the minimization of 2-furfural production. Treatment conditions were found to influence the chemical structure of extracted lignins. Cooking time and temperature influenced inversely lignin molecular weights. [less ▲]

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See detailLe temps de la reflexion... a propos de la demographie medicale et de la demographie "societale".
Scheen, André ULg

in Revue medicale de Liege (2014), 69(1), 1-3

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See detailDioxins and polychlorinated biphenyls contamination in poultry liver related to food safety - A review
Ghimpeteanu, Oana-Margarita; Militaru, Manuella; Scippo, Marie-Louise ULg

in Food Control (2014), 38

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated ... [more ▼]

The present article reviews the most important scientific literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants with high chemical stability; they are lipophilic compounds and they are not destroyed by microbial, photochemical, chemical or thermal degradation. Dioxins and PCBs are ubiquitous environmental contaminants, which are present in all marine plant and animals, birds, mammals and humans and bioaccumulate through the food chain. In the last years, there has been concern regarding food contamination with different chemical substances and their effect on food safety. More particularly, at the end of the 20th and the beginning of the 21st century, there were a series of incidents related to dioxin and PCBs, which directly affected human or contaminated the soil and accumulated in feed and then in food products, such as poultry liver. It was shown in case of dioxin incident that tetra and penta-chlorinated congeners (the most toxic ones) accumulates selectively in poultry livers. Maximal concentrations have been fixed in the European legislation for dioxins and PCBs in food from animal origin, in order to protect the consumer. Data about background poultry liver contamination are scarce and the few available show levels below the legal limit for dioxins, but data are still lacking for DL-PCBs. [less ▲]

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See detailAssociation of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood.
Savenije, Olga E.; Mahachie John, Jestinah ULg; Granell, Raquel et al

in The Journal of allergy and clinical immunology (2014)

BACKGROUND: Genome-wide association studies identified IL33 and IL-1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-receptor pathway. OBJECTIVE ... [more ▼]

BACKGROUND: Genome-wide association studies identified IL33 and IL-1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-receptor pathway. OBJECTIVE: In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes and asthma with single nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor IL1RAcP, its adaptors myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-11 receptor domain containing adaptor protein (TIRAP), and the downstream IL-1 receptor-associated kinase 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6). Furthermore, we investigated whether SNPs in this pathway show replicable evidence of gene-gene interaction. METHODS: Ninety-four SNPs were investigated in 2007 children in the PIAMA study and 7247 children in ALSPAC. Associations with wheezing phenotypes and asthma at 8 years of age were analyzed in each cohort and subsequently meta-analyzed. Gene-gene interactions were assessed through model-based multifactor dimensionality reduction in the PIAMA study, and gene-gene interactions of 10 SNP pairs were further evaluated. RESULTS: Intermediate-onset wheeze was associated with SNPs in several genes in the IL33-IL1RL1 pathway after applying multiple testing correction in the meta-analysis: 2 IL33 SNPs (rs4742170 and rs7037276), 1 IL-1 receptor accessory protein (IL1RAP) SNP (rs10513854), and 1 TRAF6 SNP (rs5030411). Late-onset wheeze was associated with 2 IL1RL1 SNPs (rs10208293 and rs13424006), and persistent wheeze was associated with 1 IL33 SNP (rs1342326) and 1 IL1RAP SNP (rs9290936). IL33 and IL1RL1 SNPs were nominally associated with asthma. Three SNP pairs showed interaction for asthma in the PIAMA study but not in ALSPAC. CONCLUSIONS: IL33-IL1RL1 pathway polymorphisms are associated with asthma and specific wheezing phenotypes; that is, most SNPs are associated with intermediate-onset wheeze, a phenotype closely associated with sensitization. We speculate that IL33-IL1RL1 pathway polymorphisms affect development of wheeze and subsequent asthma through sensitization in early childhood. [less ▲]

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See detailCervical cancer and HPV: Awareness and vaccine acceptability among parents in Morocco.
Mouallif, Mustapha; Bowyer, Harriet L.; Festali, Soukaina et al

in Vaccine (2014), 32(3), 409-16

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since ... [more ▼]

Cervical cancer is a major public health concern in Morocco where it represents the second most common and lethal cancer in women. Human papillomavirus (HPV) vaccines have been licensed in Morocco since 2008 but there are no available data on their acceptability. This study aimed to assess awareness of HPV and the vaccine, and to identify factors associated with acceptability of the vaccine among parents in Morocco. We carried out a questionnaire-based survey using face-to-face interviews in a sample of 852 parents (670 mothers and 182 fathers) with at least one unmarried daughter </=26 years. We collected data within public and private health centres and clinics in four regions in Morocco between July and August 2012. The main outcome measure was parental acceptability of the HPV vaccine for their daughter(s). Responses revealed very low awareness of HPV infection (4.7%) and the HPV vaccine (14.3%). None of the participants had vaccinated their daughter(s) against HPV and vaccine acceptability was low among mothers (32%) and fathers (45%). Higher education and income, previous awareness of the HPV vaccine and endorsement of the belief that a recommendation from the Ministry of Health or a doctor to have the vaccine would be encouraging, were associated with mothers' HPV vaccine acceptability. Non-acceptability among mothers was associated with having more than two daughters, believing the vaccine was expensive, lack of information and believing that whatever happens to an individual's health is God's will. The only factor associated with the fathers' acceptability of the vaccine was the cost of the vaccine. Increasing HPV and HPV vaccine awareness through educational campaigns, along with active recommendation by physicians and a publically funded vaccination programme could increase parental acceptability of the HPV vaccine in Morocco. [less ▲]

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See detailHigh Prevalence of Abdominal Aortic Aneurysm in Patients with Three-vessel Coronary Artery Disease.
Durieux, R.; VAN DAMME, Hendrik ULg; Labropoulos, N. et al

in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2014)

OBJECTIVES: Currently, the prevalence of abdominal aortic aneurysm (AAA) in patients with coronary artery disease (CAD) and the correlation between CAD severity and AAA prevalence are not clearly known ... [more ▼]

OBJECTIVES: Currently, the prevalence of abdominal aortic aneurysm (AAA) in patients with coronary artery disease (CAD) and the correlation between CAD severity and AAA prevalence are not clearly known. We conducted a prospective study to determine the prevalence of AAA in patients undergoing coronary angiography and to determine the risk factors and a coronary profile associated with AAA. METHODS: Over an 18-month period, abdominal aortic ultrasound was performed on 1,000 patients undergoing coronary angiography for suspected or known CAD, or prior to valve surgery. Clinical characteristics and coronary profile were collected from the patients. RESULTS: The overall number of previously repaired, already diagnosed, and new cases of AAA in the study population was 42, yielding a prevalence of 4.2%. Among the patients with newly detected AAAs, only two had an AAA diameter of >54 mm and were therefore treated surgically. In men aged >/=65 years, the prevalence reached 8.6%, while in men with three-vessel CAD it was 14.4%. Multivariate analysis showed that age >/=65 years (p = .003), male gender (p = .003), family history of AAA (p = .01), current smoking (p = .002), and three-vessel CAD (p < .001) were significantly associated with a higher prevalence of AAA. CONCLUSION: The prevalence of AAA was high in men aged >/=65 years and in those with three-vessel CAD regardless of age. While our findings do not prove the cost-effectiveness of screening for AAA in these high risk patients, they do support the usefulness of a quick ultrasound examination of the abdominal aorta during routine transthoracic echocardiography in such patients. [less ▲]

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See detailV. Van Saaze, Installation Art and the Museum : Presentation and Conservation of Changing Artworks
D'Haenens, Manon ULg

in CeROArt : Conservation, Exposition, Restauration d'Objets d'Art (2014), (9),

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See detailEuropean multicentre validation study of the accuracy of E/e' ratio in estimating invasive left ventricular filling pressure: EURO-FILLING study.
Galderisi, Maurizio; Lancellotti, Patrizio ULg; Donal, Erwan et al

in European Heart Journal - Cardiovascular Imaging (2014)

AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for ... [more ▼]

AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for calculating the ratio between the preload-dependent transmitral E velocity and the average of septal and lateral early diastolic velocities (e') of the mitral annulus. Despite its wide use, real utility of the E/e' ratio has been recently challenged in patients with either very advanced heart failure or preserved left ventricular (LV) ejection fraction. However, only few studies performed the invasive and non-invasive estimation of LVFP simultaneously. The EURO-FILLING Study will validate the E/e' ratio (and additional non-invasive estimates) against simultaneously measured LVFP obtained by left heart catheterization in a multicentre study involving reference European echo laboratories collecting a wide population sample size of cardiac patients with and without heart failure. METHODS AND RESULTS: The EURO-FILLING study is a large, prospective observational study in which simultaneous assessment of invasive and non-invasive measurements of LVFP will be acquired in eight reference European centres. Centralized reading of the collected parameters will be performed in a core laboratory. Not only standardized echo Doppler measurements but also novel echo parameters such as LV global longitudinal strain and global atrial strain (obtainable by two-dimensional speckle tracking echocardiography) will be tested for predicting invasive measurements of LVFP. CONCLUSIONS: The EURO-FILLING study is expected to provide important information on non-invasive assessment of LVFP and to contribute to the standardization of this assessment in clinical practice. [less ▲]

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See detailSimulation-based study comparing multiple imputation methods for non-monotone missing ordinal data in longitudinal settings
Donneau, Anne-Françoise ULg; Mauer, Murielle; Lambert, Philippe ULg et al

in Journal of Biopharmaceutical Statistics (2014)

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the ... [more ▼]

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the joint modeling and the fully conditional specification approaches. Their relative performance for the longitudinal ordinal data setting under the missing at random (MAR) assumption is not well documented. This paper intends to fill this gap by conducting a large simulation study on the estimation of the parameters of a longitudinal proportional odds model. The two MI methods are also illustrated in quality of life data from a cancer clinical trial. [less ▲]

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See detailEl sindrome tirogastrico autoinmune : sus efectos sobre los micronutrientes y la tumorigenesis gastrica
VALDES SOCIN, Hernan Gonzalo ULg; LUTTERI, Laurence ULg; Cavalier, Etienne ULg et al

in Revista Argentina de Endocrinologia y Metabolismo (2014), 51

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See detailAssessing the potential of an algorithm based on mean climatic data to predict wheat yield
Dumont, Benjamin ULg; Leemans, Vincent ULg; Ferrandis, Salvador et al

in Precision Agriculture (2014)

The real-time non-invasive determination of crop biomass and yield prediction is one of the major challenges in agriculture. An interesting approach lies in using process-based crop yield models in ... [more ▼]

The real-time non-invasive determination of crop biomass and yield prediction is one of the major challenges in agriculture. An interesting approach lies in using process-based crop yield models in combination with real-time monitoring of the input climatic data of these models, but unknown future weather remains the main obstacle to reliable yield prediction. Since accurate weather forecasts can be made only a short time in advance, much information can be derived from analyzing past weather data. This paper presents a methodology that addresses the problem of unknown future weather by using a daily mean climatic database, based exclusively on available past measurements. It involves building climate matrix ensembles, combining different time ranges of projected mean climate data and real measured weather data originating from the historical database or from real-time measurements performed in the field. Used as an input for the STICS crop model, the datasets thus computed were used to perform statistical within-season biomass and yield prediction. This work demonstrated that a reliable predictive delay of 3-4 weeks could be obtained. In combination with a local micrometeorological station that monitors climate data in real-time, the approach also enabled us to (i) predict potential yield at the local level, (ii) detect stress occurrence and (iii) quantify yield loss (or gain) drawing on real monitored climatic conditions of the previous few days. [less ▲]

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See detailValorisation des résidus de bois issus de l'exploitation artisanale des forêts communautaires au Cameroun : cas de la forêt communautaire de Mambioko (Gic CRCV)
Malnoury, Gauthier; Zoyiem Ngouanet, Edmond; Julve Larrubia, Cecilia et al

in Tropicultura (2014), 32(2), 90-94

L’exploitation artisanale du bois des forêts communautaires au Cameroun génère une quantité importante de résidus abandonnés au niveau des sites d’exploitation. Ces pièces de bois pourraient être ... [more ▼]

L’exploitation artisanale du bois des forêts communautaires au Cameroun génère une quantité importante de résidus abandonnés au niveau des sites d’exploitation. Ces pièces de bois pourraient être valorisées en produits commercialisables de manière à améliorer les revenus de la communauté. Cette étude a permis une première estimation de ce volume et présente différentes pistes de valorisation adaptées à la communauté de Mambioko. Cette étude de cas s’adresse à tous les acteurs de la foresterie communautaire au Cameroun et vise une valorisation rationnelle de la matière ligneuse dans un but de développement rural. [less ▲]

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See detailPortrait photographique d’écrivain et newsmagazine. Pour une approche rhétorique de l’événementialité du littéraire
Provenzano, François ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2014), 14

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See detailCorrection of vitamin D insufficiency with combined strontium ranelate and vitamin D3 in osteoporotic patients.
Rizzoli, R.; Dawson-Hughes, B.; Kaufman, J.-M. et al

in European Journal of Endocrinology (2014), 170(3), 441-50

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D ... [more ▼]

OBJECTIVE: This study aims to investigate the efficacy and safety of oral fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU daily vs strontium ranelate 2 g daily for correcting vitamin D insufficiency in osteoporosis. DESIGN: A 6-month international, randomized, double-blind, parallel-group, phase 3 study. METHODS: A total of 518 men and postmenopausal women aged >/=50 years with primary osteoporosis (T-score </=-2.5 s.d.) and serum 25-hydroxyvitamin D (25(OH)D) >22.5 nmol/l were included. Patients were allocated to strontium ranelate 2 g/vitamin D3 1000 IU daily (n=413) or strontium ranelate 2 g daily (n=105). The participants received calcium 1 g daily. The primary endpoint was serum 25(OH)D at last post-baseline evaluation during 3 months. RESULTS: Both groups were comparable at baseline. Mean baseline of 25(OH)D was 44.1+/-14.6 nmol/l. After 3 months, the percentage of patients with 25(OH)D >/=50 nmol/l was higher with strontium ranelate/vitamin D3 vs strontium ranelate (84 vs 44%, P<0.001; adjusted between-group odds ratio=6.7; 95% CI, 4.2-10.9). The efficacy of the fixed-dose combination on 25(OH)D was maintained at 6 months (86 vs 40%, P<0.001). Mean 25(OH)D was 65.1 and 49.5 nmol/l, respectively, after 3 months and 66.9 and 45.4 nmol/l after 6 months. Physical performance improved in both groups. Falls were 17 and 20% in the strontium ranelate/vitamin D3 and strontium ranelate groups respectively. Parathyroid hormone levels were inversely correlated with 25(OH)D. No clinically relevant differences in safety were observed. CONCLUSIONS: This study confirms the efficacy and safety of fixed-dose combination of strontium ranelate 2 g/vitamin D3 1000 IU for correction of vitamin D insufficiency in osteoporotic patients. [less ▲]

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See detailCompte-rendu de l'ouvrage de Eilene Powell et al.: La novela sugestiva
Ceballos Viro, Alvaro ULg

in Iberoamericana America Latina-Espana-Portugal (2014), (53), 218-220

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See detailPhotic memory for executive brain responses
Chellappa*, Sarah Laxhmi ULg; Ly*, Julien ULg; Meyer, Christelle ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2014), Epub ahead of print

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See detailL’INTÉRÊT DE LA RADIOTHÉRAPIE «ABLATIVE» EN PRENANT COMME MODÈLE LA MÉTASTASE D’UN CANCER RÉNAL À CELLULES CLAIRES
COUCKE, Philippe ULg; JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 94-100

La radiothérapie en conditions stéréotaxiques, guidée par l’imagerie embarquée, est une alternative valable aux autres modalités de traitement ablatif, en particulier dans le contexte du cancer rénal ... [more ▼]

La radiothérapie en conditions stéréotaxiques, guidée par l’imagerie embarquée, est une alternative valable aux autres modalités de traitement ablatif, en particulier dans le contexte du cancer rénal métastatique (mRCC). L’efficacité du traitement dépend de la dose totale et la dose par fraction et se traduit en Dose Biologique Efficace (BED). Les tech - niques actuelles permettent d’appliquer des doses par frac - tion élevée (> 8 à 10 Gy), ce qui se traduit en effet biologique fondamentalement différent de celui observé dans le contexte d’une radiothérapie conventionnelle, résultant en un taux de réponse local atteignant 80 à 90%. Ce taux de réponse contre - dit le concept historique de tumeur «radiorésistante». L’effet thérapeutique s’explique en partie par un effet anti-angiogé - nique majeur induit par la réponse apoptotique des cellules endothéliales dans la tumeur. Ceci ouvre de nouvelles perspec - tives, en particulier dans le domaine des traitements combi - nant radiothérapie ablative et substances anti-angiogéniques. [less ▲]

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See detailScreening for malnutrition in lung cancer patients undergoing therapy
BARTHELEMY, Nicole ULg; Streel, Sylvie ULg; Donneau, Anne-Françoise ULg et al

in Supportive Care in Cancer (2014)

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See detailReview of Postcolonial Ecologies: Literatures of the Environment edited by Elizabeth DeLoughrey and George B. Handley
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2014), 88(1-2), 182-184

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See detailCompte-rendu de l'ouvrage de P. Pérez del Solar: Imágenes del desencanto: nueva historieta española
Ceballos Viro, Alvaro ULg

in Iberoamericana America Latina-Espana-Portugal (2014), (53), 220-222

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See detailResponse to Dr Bolland's eLetter: Strontium and cardiovascular events.
REGINSTER, Jean-Yves ULg

in Annals of the rheumatic diseases (2014), 73(2), 9

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See detailThe year 2013 in the European Heart Journal - Cardiovascular Imaging: Part II.
Plein, Sven; Edvardsen, Thor; Pierard, Luc ULg et al

in European heart journal cardiovascular Imaging (2014)

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in ... [more ▼]

The new multi-modality cardiovascular imaging journal, European Heart Journal - Cardiovascular Imaging, was created in 2012. Here we summarize the most important studies from the journal's second year in two articles. Part I of the review has summarized studies in myocardial function, myocardial ischaemia, and emerging techniques in cardiovascular imaging. Part II is focussed on valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases. [less ▲]

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See detailCan faecal markers detect a short term reduction in forage intake by cattle?
Benvenutti, Marcelo A.; Coates, David B.; Bindelle, Jérôme ULg et al

in Animal Feed Science & Technology (2014), 194

Detection of a reduction in forage intake is particularly relevant in grazing animals due to its negative effect on animal performance. Estimations of intake reduction using faecal markers can be ... [more ▼]

Detection of a reduction in forage intake is particularly relevant in grazing animals due to its negative effect on animal performance. Estimations of intake reduction using faecal markers can be inaccurate due to the time delay between a change in forage intake and the subsequent change in faecal output. This delay may vary depending on forage quality and marker type. A pen study was conducted for 29 days to test the efficacy of liquid (PEG = polyethylene glycol) and solid (alkanes and CrCl3 = chromium chloride) phase faecal markers to detect a reduction in intake by steers of diets that varied in forage quality. Ten Brahman cross steers (296 ± 16 kg) were allocated equally to diets of leafy, high quality buffel grass (Cenchrus ciliaris) hay and stemmy, low quality buffel grass hay. Hay was offered ad libitum from day 1 to 7, at 90% of voluntary intake from day 8 to 14 and then reduced by 8% each day from day 15 to 24. On day 5 each steer was dosed with two slow release alkane capsules; also, steers received a single daily dose of PEG and CrCl3 at 09:00 on days 5 to 24. Actual and marker derived estimates of forage intake over days 10 to 22 were assessed by repeated-measures analysis of variance. Overall marker recovery rates were satisfactory (0.92 to 1.03) and there was a significant (P < 0.001) progressive decrease in daily recovery rate over time for all markers and diets. Actual and marker-determined forage intake declined over the course of the experiment for both leafy and stemmy hay diets (P < 0.001) for all three markers. There was a lag of 3 to 5 days to detect a significant reduction in estimated intake by steers using markers. The lag period was similar for both liquid and solid phase markers. Results of this experiment indicated that decreases in forage intake by cattle could be detected using indigestible faecal markers, albeit in association with (i) progressively larger reductions in actual forage intake, and (ii) a time lag of 3 to 5 days between the decrease in actual intake and its statistical detection using faecal markers. [less ▲]

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See detailExciton dissociation at donor-acceptor heterojunctions: Dynamics using the collective effective mode representation of the spin-boson model
Chenel, Aurélie; Mangaud, Etienne; Burghardt, Irène et al

in Journal of Chemical Physics (2014), 140

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See detailLa primauté de l'intentionnalité et ses conséquences épistémologiques
Boccaccini, Federico ULg

in Bulletin d'Analyse Phénoménologique (2014)

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See detailEstimation of the error density in a semiparametric transformation model
Colling, Benjamin; Heuchenne, Cédric ULg; Samb, Rawane et al

in Annals of the Institute of Statistical Mathematics (2014)

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See detailSolid–fluid transition modelling in geomaterials and application to a mudflow interacting with an obstacle
Prime, Noémie ULg; Dufour, Frédéric; Darve, Félix

in International Journal for Numerical and Analytical Methods in Geomechanics (2014)

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See detailEffect of the kinematic hardening in the simulations of the straightening of long rolled profiles
Bouffioux, Chantal ULg; Boman, Romain ULg; Caillet, Nicolas et al

in Key Engineering Materials [=KEM] (2014), 611-612

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are ... [more ▼]

Residual stresses and lack of straightness appear during the cooling of sheet piles where the initial temperature field is not homogeneous. To meet the standards, the long hot rolled pieces are straightened using a series of rollers placed alternately above and below the pieces with shifts which create a succession of bendings. The process is modeled to study the impact of the industrial parameters ( the duration of the cooling and the rollers positions), to improve the final geometry and to reduce the residual stresses.Tests are carried out on this structural steel to observe the material behavior, then material laws are chosen and parameters of these laws are defined using and inverse method. Two sets of material data are obtained: for the first one, the hardening is supposed to be isotropic, and for the second one, additional tests are performed to describe isotropic and kinematic hardenings.The cooling followed by the straightening is then simulated by the finite element with these two sets of date. The comparison of the rollers forces, the deformation and the residual stresses show the impact of the kinematic hardening on such a process where the material undergoes a sucession of the tensions and compressions. The real forces applied by the rollers,the real curvature of the interlocks at the end of the straightening process and the distribution of the residual longitudinal stresses measured on the web using the ring core method are used to validate the numerical model. [less ▲]

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See detailThe impact of aging and hearing status on verbal working memory
Verhaegen, Clémence ULg; Collette, Fabienne ULg; Majerus, Steve ULg

in Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition (2014), 21(4), 464-482

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See detailThe Politics of MGNREGA in Andhra Pradesh
Maiorano, Diego ULg

in World Development : The Multi-Disciplinary International Journal Devoted to the Study and Promotion of World Development (2014)

The Mahatma Gandhi National Rural Employment Guarantee Act is India's (and the world's) largest employment programme. While many analysis exist on its impact and implementation faults, scant attention has ... [more ▼]

The Mahatma Gandhi National Rural Employment Guarantee Act is India's (and the world's) largest employment programme. While many analysis exist on its impact and implementation faults, scant attention has been dedicated to how political dynamics influence its implementation. This paper will try to fill this gap with evidence from the southern state of Andhra Pradesh. It will argue that the implementation performance of the programme has been fairly good, despite the abysmal performance of the state government with previous employment programmes. The key factor in determining such a shift was the political commitment of the state’s chief minister. [less ▲]

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See detailQuand le savoir s'emmêle... La construction discursive de la norme chez les locuteurs non experts
Meunier, Deborah ULg; Rosier, Laurence

in Carnets du Cediscor (2014), 12

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See detailContinuity amid change in India’s political economy: from “socialist” to “neoliberal” India.
Maiorano, Diego ULg

in Economic and Political Weekly (2014)

The aim of this paper is to show that the social coalition that benefited from India’s central government’s economic policies remained unchanged between the pre and post economic reforms periods. More ... [more ▼]

The aim of this paper is to show that the social coalition that benefited from India’s central government’s economic policies remained unchanged between the pre and post economic reforms periods. More specifically, this paper will argue that the economic policies promoted by the central government between 1980 and 2004 – irrespective of the political party heading the Cabinet – mostly benefited the middle class and the corporate sector, while the poor and the rural world were clearly relegated to a secondary position in the governments’ policy priorities. The paper will highlight six important lines of continuity in India’s economic policy and will argue that if we look at who the “winner” and the “losers” of these policy processes are, the economic reforms of the early 1990s do not separate two different phases of India’s development path. From this point of view the election of the United Progressive Alliance (UPA) government in 2004 might constitute a more important break with the past. [less ▲]

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See detailInfluence of the surface morphology of smooth platinum electrodes for the sodium borohydride oxidation reaction
Olu, Pierre-Yves; Gilles, Bruno; Job, Nathalie ULg et al

in Electrochemistry Communications (2014), 43

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See detailElectrochemical Co-Deposition of Phosphonate-Modified Carbon Nanotubes and Tantalum on Nitinol
Maho, Anthony ULg; Detriche, Simon; Fonder, Grégory et al

in ChemElectroChem (2014), 1(5), 896--902

Nitinol substrates are coated with thin surface films made of carbon nanotubes (CNTs) and tantalum (Ta), with the aim of fostering their osseointegration aptitudes. Exceptional mechanical and chemical ... [more ▼]

Nitinol substrates are coated with thin surface films made of carbon nanotubes (CNTs) and tantalum (Ta), with the aim of fostering their osseointegration aptitudes. Exceptional mechanical and chemical characteristics of CNTs combined with the resistance to corrosion and strong bioactive properties of tantalum allow for the generation of adherent, protective and functional layers on metallic biomaterial platforms. The composite coatings are elaborated on Nitinol through a two-step electrochemical protocol; firstly, through the electrophoretic deposition of phosphonate-modified CNTs and, secondly, with electrodeposition of Ta. As a preliminary step, phosphonate groups, acting, in addition, as specific Ta-capture entities, are introduced on the CNT sidewalls by means of diazonium derivatives, which imply no hard oxidative treatment. X-ray photoelectron spectroscopy as well as scanning and transmission electronic microscopies are used to analyse the chemical composition, structure and morphology of the different layers. [less ▲]

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See detailCurrent impact and future directions of high throughput sequencing in plant virus diagnostics.
Massart, Sébastien ULg; Olmos, Antonio; Jijakli, Haissam ULg et al

in Virus Research (2014), 188

The ability to provide a fast, inexpensive and reliable diagnostic for any given viral infection is a key parameter in efforts to fight and control these ubiquitous pathogens. The recent developments of ... [more ▼]

The ability to provide a fast, inexpensive and reliable diagnostic for any given viral infection is a key parameter in efforts to fight and control these ubiquitous pathogens. The recent developments of highthroughput sequencing (also called Next Generation Sequencing – NGS) technologies and bioinformatics have drastically changed the research on viral pathogens. It is now raising a growing interest for virus diagnostics. This review provides a snapshot vision on the current use and impact of high throughput sequencing approaches in plant virus characterization. More specifically, this review highlights the potential of these new technologies and their interplay with current protocols in the future of molecular diagnostic of plant viruses. The current limitations that will need to be addressed for a wider adoption of high-throughput sequencing in plant virus diagnostics are thoroughly discussed. [less ▲]

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See detailCharacterization of Black locust (Robinia pseudoacacia L.) heartwood extractives: identification of resveratrol and piceatannol
Sergent, Thérèse; Kohnen, Stéphane; Jourez, Benoît ULg et al

in Wood Science and technology (2014)

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less ... [more ▼]

Robinia pseudoacacia L. heartwood is characterized by a very high natural durability. However, a significant difference was observed between the mature and juvenile heartwood, the latter presenting less durability against fungi decay, which could be attributed to lower extractive content. In order to elucidate this idea, extractives from mature and juvenile heartwoods of black locust trees were investigated. Results showed that extractive and phenolic contents were higher in mature than in juvenile heartwoods. The identification of phenolic compounds by UPLC–DAD–MS/MS revealed, for the first time, the presence of resveratrol and piceatannol. These two stilbenes as well as the flavonoid dihydrorobinetin were present at the highest level in mature heartwood, and as they are known antifungals, they could account for the great durability of mature heartwood. The stilbenes were detected in significant amounts particularly in mature heartwood where piceatannol reached a level tenfold higher than that reported for Japanese knotweed roots, the primary natural source of these stilbenes, whereas resveratrol level was comparable with reported values. As resveratrol and piceatannol receive increasing demand for nutraceutical, cosmetic and, possibly, pharmaceutical purposes, due to their beneficial health effects, this study underlines the use of R. pseudoacacia as a promising sustainable and economical source of resveratrol and piceatannol. [less ▲]

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See detailLA RADIOBIOLOGIE POUR LES NÉOPHYTES
COUCKE, Philippe ULg; MARTINIVE, Philippe ULg

in Revue Médicale de Liège (2014), 69(Supp 1), 16-19

La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec ... [more ▼]

La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec l’épargne des tissus sains avoisinants, rend possible une nouvelle exploitation de concept de radio - biologie. L’exemple type est la redécouverte des traitements hypo-fractionnés. [less ▲]

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See detailMicrobial heterogeneity affects bioprocess robustness: Dynamic single cell analysis contribute to understanding microbial populations
Delvigne, Frank ULg; Goffin, Philippe

in Biotechnology Journal (2014), 9(1), 61-72

Heterogeneity or segregation of microbial populations has been the subject of much research, but the real impact of this phenomenon on bioprocesses remains not well understood. The main reason behind this ... [more ▼]

Heterogeneity or segregation of microbial populations has been the subject of much research, but the real impact of this phenomenon on bioprocesses remains not well understood. The main reason behind this lack of knowledge is the difficulty for monitoring microbial population heterogeneity in dynamic process conditions. The main concepts leading to microbial population heterogeneity in the context of bioprocesses have been summarized by two distinct hypotheses. The first one involves the individual history of microbial cells or “path” followed during their residence time inside process equipment. The second one involves a coordinated response of the microbial population as a bet-hedging strategy in order to cope with process-related stresses. The respective contribution of each hypothesis to microbial heterogeneity in bioprocesses is still unclear. This statement illustrates the fact that, although microbial phenotypic heterogeneity has been thoroughly investigated at the fundamental level, the implications of this phenomenon in the context of microbial bioprocesses are still subjected to debate. At this time, automated flow cytometry is the best technique for the investigation of microbial heterogeneity in process conditions. However, dedicated software and relevant biomarkers are needed for its proper integration as a bioprocess control tool. [less ▲]

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See detailLe myélome multiple asymptomatique : le paysage thérapeutique change
CAERS, Jo ULg; BEGUIN, Yves ULg

in Oncol. Hematol. (2014), 8

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade ... [more ▼]

Le myélome multiple est le deuxième cancer hématologique en termes de fréquence avec plus de 700 nouveaux cas chaque année en Belgique. Le myélome asymptomatique, ou smoldering mye/omo, est un stade précurseur du myélome multiple. En moyenne, les patients présentant un myélome asymptomatique ont un risque annuel de progression en myélome déclaré de 10%. Différents facteul"s ont été combinés dans des modélisations pronostiques: le rapport des chaînes légères, les anomalies radiologiques, la présence d'une gammapathie évolutive et l'infiltration médullaire > 60% ont récemment été identifiés comme facteurs prédictifs d'une progression précoce pour lesquels certains auteurs évoquent la mise en roùte d'un traitement anti-myélome. Cette stratégie thérapeutique précoce a démontré son efficacité dans une étude randomisée qui comparait un traitement par lénalidornide et dexaméthasone avec une approche attentiste chez des patients à risque. [less ▲]

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See detailCombating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes
SCHEEN, André ULg; Van Gaal, Luc

in The Lancet Diabetes & Endocrinology (2014)

The increasing prevalence of obesity is contributing substantially to the ongoing epidemic of type 2 diabetes. Abdominal adiposity, a feature of ectopic fat syndrome, is associated with silent ... [more ▼]

The increasing prevalence of obesity is contributing substantially to the ongoing epidemic of type 2 diabetes. Abdominal adiposity, a feature of ectopic fat syndrome, is associated with silent inflammation, abnormal hormone secretion, and various metabolic disturbances that contribute to insulin resistance and insulin secretory defects, resulting in type 2 diabetes, and induce a toxic pattern that leads to cardiovascular disease, liver pathologies, and cancer. Despite the importance of weight control strategies in the prevention and management of type 2 diabetes, long-term results from lifestyle or drug interventions are generally disappointing. Furthermore, most of the classic glucose-lowering drugs have a side-effect of weight gain, which renders the management of most overweight or obese people with type 2 diabetes even more challenging. Many anti-obesity pharmacological drugs targeting central control of appetite were withdrawn from the market because of safety concerns. The gastrointestinal lipase inhibitor orlistat was the only anti-obesity drug available until the recent US, but not European, launch of phentermine–controlled-release topiramate and lorcaserin. Improved knowledge about bodyweight regulation opens new prospects for the potential use of peptides derived from the gut or the adipose tissue. Combination therapy will probably be necessary to avoid compensatory mechanisms and potentiate initial weight loss while avoiding weight regain. New glucose-lowering treatments, especially glucagon-like peptide-1 receptor agonists and sodium glucose cotransporter-2 inhibitors, offer advantages over traditional antidiabetic drugs by promoting weight loss while improving glucose control. In this Review, we explore the overlapping pathophysiology and also how various treatments can, alone or in combination, combat the dual burden of obesity and type 2 diabetes. [less ▲]

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See detailLa recette commentée sur la toile: un genre renouvelé?
Meunier, Deborah ULg; Rosier, Laurence

in Arena Romanistica (2014), 14

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of ... [more ▼]

The principle of procedurality, as well as the practice of transmission, define culinary discourse in the form of recipes, a sub-genre of emblematic discourse. Electronic tools have permitted a renewal of the recipe’s very form, which was initially a case of linear transmission in a chronological sense, towards a dialogal and polyphonic form in which the original posted recipe becomes recipe only when it is enlivened with commentaries which complete and perform it. Our contribution aims to show this discursive co-construction. From the point of view of genres, we will also see that those genres which are known as monologal or fixed can evolve towards dialogal and dialogical forms. [less ▲]

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See detailEXPLORATION ET TRAITEMENT D’UN CARCINOME EPIDERMOIDE GANGLIONNAIRE CERVICAL SANS PRIMITIF DECELE
WERENNE, Xavier ULg; SAUTOIS, Brieuc ULg; DEMEZ, Pierre ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 58-62

A l’heure actuelle, le bilan à réaliser après décou - verte d’une adénopathie cervicale est bien codifié. Le PET- scan, dans un premier temps controversé, s’affirme étude après étude comme un élément ... [more ▼]

A l’heure actuelle, le bilan à réaliser après décou - verte d’une adénopathie cervicale est bien codifié. Le PET- scan, dans un premier temps controversé, s’affirme étude après étude comme un élément essentiel. La stratégie de traitement pratiquée dans la plupart des centres consiste en un évidemment cervical suivi de radiothérapie portant sur les muqueuses pharyngées ainsi que sur les relais ganglion - naires cervicaux bilatéraux avec éventuelle association à une chimiothérapie. Celle-ci est ajoutée en fonction de facteurs anatomo-pathologiques de mauvais pronostic, mais elle n’a pas fait la preuve de sa supériorité. De multiples études de phase II aboutissent d’ailleurs à des conclusions opposées. En dehors de données issues d’études randomisées, le traitement aujourd’hui se décide par analogie à ceux qui sont appliqués lorsque le site primitif tumoral est identifié dans la sphère ORL. [less ▲]

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See detailRecouvrement d'un crédit hypothécaire et accumulation des intérêts
Biquet, Christine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2014), (5), 205-216

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See detailEndocrine disruptors: A relevant issue for neuroendocrinology also!
Balthazart, Jacques ULg; Levine, Jon E.

in Frontiers in neuroendocrinology (2014), 35(1), 1

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See detailFirst isolation and molecular characterization of foot-and-mouth disease virus in Benin
Gorna, K; Houndjè, E; Romey, A et al

in Veterinary Microbiology (2014)

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See detailEtude de la dynamique des populations d'insectes sur la culture du riz NERICA dans les conditions du Masuku, Sud-Est du Gabon (Franceville)
ONDO OVONO, Paul; GATARASI, Thaddée; OBAME MINKO, Daniel et al

in International Journal of Biological and Chemical Sciences (2014)

La dynamique des populations d’insectes sur la culture du riz a été étudiée durant toutes les phases de croissance. L’essai a été installé sur les parcelles pédagogiques de l’Institut National Supérieur ... [more ▼]

La dynamique des populations d’insectes sur la culture du riz a été étudiée durant toutes les phases de croissance. L’essai a été installé sur les parcelles pédagogiques de l’Institut National Supérieur d’Agronomie et de Biotechnologies à Franceville. Il s’inscrit dans le cadre de la poursuite des travaux d’évaluation de l’adaptabilité de nouvelles variétés de riz de type NERICA, introduites dans la province du Haut –Ogooué au Sud-Est du Gabon. L’objectif de la présente étude est de collecter des informations concernant les insectes susceptibles de s’attaquer au riz et de sélectionner les variétés NERICA qui résistent le mieux aux attaques. Chacune des six variétés de type NERICA (1, 4, 11, 12, 14 et 17) a été semée en utilisant un dispositif en blocs complètement randomisés avec trois répétitions, en 2010 et 2011. La collecte des insectes volants a été effectuée au moyen de pièges aériens et du filet entomologique. Au sol, la capture s’est faite au moyen de pièges. Les larves d’insectes foreurs des tiges, les chenilles et les pucerons des racines ont été capturés à la main. Au total, 46 familles appartenant à 9 ordres ont été recensées donc 29 renferment des espèces nuisibles et définies comme ravageuses du riz. Les 17 autres familles sont classées comme insectes utiles. Les stades de tallage, d’initiation paniculaire et d’épiaison ont été en général les plus visités par les différentes familles d’insectes. Les variétés NERICA 1 et NERICA 11 ont présenté les plus faibles taux d’infestation et de dégâts. Par ailleurs, la perte en biomasse a été considérable chez toutes les variétés. [less ▲]

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See detailPolitical Participation of Latin American Migrants in Andalusia: Opportunities and Constraints
Bermudez Torres, Anastasia ULg; Escriva, Angeles; Moraes, Natalia

in Migraciones Internacionales (2014), 7(3), 73-98

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The ... [more ▼]

The main purpose of this article is to present the results of a research project on the political participation of Latin American migrants in Andalusia (mainly in the cities of Seville and Huelva). The project uses a broad concept of what political participation constitutes, including both civic practices and activities associated with conventional politics, and adopts a transnational perspective. It is based on 45 semi-structured interviews with politically active migrants and members of political parties and other institutions. The article highlights some of the main findings of the research, including the importance of taking into account migrants’ previous political experiences, as well as the role played by migrant associations in order to better understand their political practices. [less ▲]

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See detailConcepts d’efficience et de productivité de l’eau (synthèse bibliographique)
Kambou, Donkora ULg; Xanthoulis, Dimitri ULg; Ouattara, Korodjouma et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(1),

Water efficiency and productivity indicators are used in many scientific disciplines, usually to account for water losses that occur during its use, or products generated per unit of water consumed. The ... [more ▼]

Water efficiency and productivity indicators are used in many scientific disciplines, usually to account for water losses that occur during its use, or products generated per unit of water consumed. The interpretation of these indicators is very diverse in the literature. However, the majority of definitions consider water efficiency as a measure of the effectiveness of irrigation, and view water productivity as a measure of the effectiveness of the physiological processes of both biomass production and crop yield formation, linked to the actual consumption of water by the crops. Thus, the consensus seems to be for water application efficiency (Ea) to be considered as the ratio of actual evapotranspiration to the water applied and productivity as the ratio of yield to actual evapotranspiration. The point of divergence relates fundamentally to the understanding of the constituent expressions of productivity (PE, product/“water consumed”) and efficiency of water application (Ea, “water consumed”/“applied water”). Indeed, the term “water consumed” is referred to variously by several authors as “actual evapotranspiration”, “gross irrigation plus rainfall”, “evapotranspiration plus water lost at the plot but beneficial to other users”, etc. Furthermore, while providing more details on the concepts of efficiency and water productivity, this review shows that the factors affecting these indicators have not yet been sufficiently elucidated. Thus, one of the axes of investigation could be to model the application efficiency of water firstly, according to water management practices and secondly, in terms of productivity levels in relation to the crop establishment period. [less ▲]

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See detailSubspace-based identification of a nonlinear spacecraft in the time and frequency domains
Noël, Jean-Philippe ULg; Marchesiello, Stefano; Kerschen, Gaëtan ULg

in Mechanical Systems & Signal Processing (2014), 43(1-2), 217-236

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure. To this end, two nonlinear subspace identification methods formulated in the time and ... [more ▼]

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure. To this end, two nonlinear subspace identification methods formulated in the time and frequency domains are exploited, referred to as the TNSI and FNSI methods, respectively. The modal parameters of the underlying linear structure and the coefficients of the nonlinearities will be estimated by these two approaches based on periodic random measurements. Their respective merits will also be discussed in terms of both accuracy and computational efficiency and the use of stabilisation diagrams in nonlinear system identification will be introduced. The application of interest is the SmallSat spacecraft developed by EADS-Astrium, which possesses an impact-type nonlinear device consisting of eight mechanical stops limiting the motion of an inertia wheel mounted on an elastomeric interface. This application is challenging for several reasons including the non-smooth nature of the nonlinearities, high modal density and high non-proportional damping. [less ▲]

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See detailSurgery for severe ischemic mitral regurgitation.
Magne, Julien; Pierard, Luc ULg

in The New England journal of medicine (2014), 370(15), 1462

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See detailLateral Magnetic Near-Field Imaging of Plasmonic Nanoantennas With Increasing Complexity
Denkova, D.; Verellen, N.; Silhanek, Alejandro ULg et al

in Small : Nano Micro (2014)

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field ... [more ▼]

The design of many promising, newly emerging classes of photonic metamaterials and subwavelength confinement structures requires detailed knowledge and understanding of the electromagnetic near-field interactions between their building blocks. While the electric field distributions and, respectively, the electric interactions of different nanostructures can be routinely measured, for example, by scattering near-field microscopy, only recently experimental methods for imaging the magnetic field distributions became available. In this paper, we provide direct experimental maps of the lateral magnetic near-field distributions of variously shaped plasmonic nanoantennas by using hollow-pyramid aperture scanning near-field optical microscopy (SNOM). We study both simple plasmonic nanoresonators, such as bars, disks, rings and more complex antennas. For the studied structures, the magnetic near-field distributions of the complex resonators have been found to be a superposition of the magnetic near-fields of the individual constituting elements. These experimental results, explained and validated by numerical simulations, open new possibilities for engineering and characterization of complex plasmonic antennas with increased functionality. [less ▲]

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See detailModulating effect of COMT genotype on the brain regions underlying proactive control process during inhibition
Jaspar, Mathieu ULg; Genon, Sarah ULg; Muto, Vincenzo ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 50

Introduction. Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions ... [more ▼]

Introduction. Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to three groups of 15 young adults according to their COMT Val158Met genotype [Val/Val (VV), Val/Met (VM) and Met/Met (MM)]. Based on the theory of dual mechanisms of control (Braver, et al., 2007), the Stroop task has been built to induce proactive or reactive control processes according to the task context. Results. Behavioral results did not show any significant group differences for reaction times but Val allele carriers individuals are less accurate in the processing of incongruent items. fMRI results revealed that proactive control is specifically associated with increased activity in the anterior cingulate cortex (ACC) in carriers of the Met allele, while increased activity is observed in the middle frontal gyrus (MFG) in carriers of the Val allele. Conclusion. These observations, in keeping with a higher cortical dopamine level in MM individuals, support the hypothesis of a COMT Val158Met genotype modulation of the brain regions underlying proactive control, especially in frontal areas as suggested by Braver et al. [less ▲]

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See detailEchocardiographic reference ranges for normal cardiac chamber size: results from the NORRE study.
Kou, Seisyou; Caballero, Luis; Dulgheru, Raluca et al

in European heart journal cardiovascular Imaging (2014), 15(6), 680-690

AIMS: Availability of normative reference values for cardiac chamber quantitation is a prerequisite for accurate clinical application of echocardiography. In this study, we report normal reference ranges ... [more ▼]

AIMS: Availability of normative reference values for cardiac chamber quantitation is a prerequisite for accurate clinical application of echocardiography. In this study, we report normal reference ranges for cardiac chambers size obtained in a large group of healthy volunteers accounting for gender and age. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following chamber quantitation protocols approved by the European Association of Cardiovascular Imaging. METHODS: A total of 734 (mean age: 45.8 +/- 13.3 years) healthy volunteers (320 men and 414 women) were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was performed on all subjects following pre-defined protocols. There were no gender differences in age or cholesterol levels. Compared with men, women had significantly smaller body surface areas, and lower blood pressure. Quality of echocardiographic data sets was good to excellent in the majority of patients. Upper and lower reference limits were higher in men than in women. The reference values varied with age. These age-related changes persisted for most parameters after normalization for the body surface area. CONCLUSION: The NORRE study provides useful two-dimensional echocardiographic reference ranges for cardiac chamber quantification. These data highlight the need for body size normalization that should be performed together with age-and gender-specific assessment for the most echocardiographic parameters. [less ▲]

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See detailMagnetocaloric effect of monovalent K doped manganites Pr0.6Sr0.4−xKxMnO3 (x=0 to 0.2)
Thaljaoui, R.; Boujelben, W.; Pękała, M. et al

in Journal of Magnetism and Magnetic Materials (2014), 352(0), 6-12

Magnetic and magnetocaloric properties are reported for polycrystalline monovalent potassium doped manganites Pr0.6Sr0.4−xKxMnO3 (x=0, 0.05, 0.1, 0.15 and 0.2) crystallized in orthorhombic structure with ... [more ▼]

Magnetic and magnetocaloric properties are reported for polycrystalline monovalent potassium doped manganites Pr0.6Sr0.4−xKxMnO3 (x=0, 0.05, 0.1, 0.15 and 0.2) crystallized in orthorhombic structure with Pnma space group. The increasing K content shifts the paramagnetic to ferromagnetic transition temperature from 310 K for x=0 to 269 K for x=0.2. The magnetic entropy change under magnetic field variation of 2 T is found to be 1.95, 3.09, 2.89, 3.05 and 3.2 J/kgK for x varying from 0 to 0.2, respectively. The highest relative cooling power of 102 J/kg is observed for the undoped sample. The sensitivity of magnetic entropy change to magnetic field is estimated by a local N(T) exponent exhibiting the characteristic temperature variation. Phenomenological universal curves of entropy change and Arrott plots confirm the second order phase transition. [less ▲]

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See detailGlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolysporaerythraea
Li-Li, Yao; Cheng-Heng, Liao; Gang, Huang et al

in Applied Microbiology and Biotechnology (2014)

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See detailChâteau fort d’Ecaussinnes-Lalaing (Hainaut) : de nouveaux matériaux pour une chronologie du bâti
Maggi, Christophe ULg; Blain, Sophie ULg; Bavay, Gérard et al

in Bulletin de la Commission royale des Monuments, Sites et Fouilles (2014), 25

Situé dans le Hainaut, dominant le vallon de la Senette, le château-fort d’Écaussinnes a fait l’objet de diverses monographies. Pourtant, bien des études du bâti restent à faire, dans la foulée de la plus ... [more ▼]

Situé dans le Hainaut, dominant le vallon de la Senette, le château-fort d’Écaussinnes a fait l’objet de diverses monographies. Pourtant, bien des études du bâti restent à faire, dans la foulée de la plus récente que l’on doit à Philippe Sosnowska. En mars 2012, une étude typologique et dendrochronologique des charpentes, à l’occasion de travaux de restauration aux toitures, apporte quelques éléments nouveaux. L’analyse porte sur les charpentes de toiture de la chapelle et des ailes ouest et nord. Elle a été demandée par les architectes Paul Delaisse et Michel Micciche dans le cadre de la restauration des toitures. [less ▲]

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See detailComprehensive plasma profiling for the characterization of graft-versus-host disease biomarkers
De Bock, Muriel; BEGUIN, Yves ULg; Leprince, Pierre ULg et al

in Talanta (2014), 125

Acutegraft-versus-hostdisease(aGVHD)remainsalife-threateningcomplicationofhematopoieticstem cell transplantation(HSCT)thereforelimitingitsapplication.TooptimizethemanagementofaGVHDand reduce therapy ... [more ▼]

Acutegraft-versus-hostdisease(aGVHD)remainsalife-threateningcomplicationofhematopoieticstem cell transplantation(HSCT)thereforelimitingitsapplication.TooptimizethemanagementofaGVHDand reduce therapy-relatedtoxicity,earlyspecific markersareneeded.Themainobjectiveofthisstudywas to uncoverdiagnosticbiomarkersbycomparingplasmaproteinprofiles ofpatientsatthetimeofacute GVHDdiagnosiswiththoseofpatientsundergoingHSCTwithoutaGVHD.Additionalanalysisofsamples taken 15daysbeforeaGVHDdiagnosiswasalsoperformedtoevaluatethepotentialofournewly discoveredbiomarkersforearlydiagnosis.Togetcomplementaryinformationfromplasmasamples, we usedthreedifferentproteomicapproaches,namely2D-DIGE,SELDI-TOF-MSand2D-LC-MSE. Weidentified andconfirmed bythemeansofindependenttechniques,thedifferentialexpression of severalproteinsindicatingsignificantly increasedinflammation responseanddisturbanceinthe coagulation cascade.Thevariationoftheseproteinswasalreadyobserved15daysbeforeGVHD diagnosis, suggestingthepotentialearlydetectionofthediseasebeforesymptomsappearance. Finally,logisticregressionanalysisdeterminedacompositebiomarkerpanelcomprising fibrinogen, fragment of fibrinogenbetachain,SAA,prothrombinfragments,apolipoproteinA1andhepcidinthat optimallydiscriminatedpatientswithandwithoutGVHD.Theareaunderthereceiveroperating characteristiccurvedistinguishingthese2groupswas0.95. [less ▲]

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See detailPrevalence of vitamin D inadequacy in European women aged over 80 years
Bruyère, Olivier ULg; Slomian, Justine ULg; Beaudart, Charlotte ULg et al

in Archives of Gerontology & Geriatrics (2014)

Inadequate vitamin D status is associated with secondary hyperparathyroidism and increased bone turnover and bone loss, which in turn increases fracture risk. The objective of this study is to assess the ... [more ▼]

Inadequate vitamin D status is associated with secondary hyperparathyroidism and increased bone turnover and bone loss, which in turn increases fracture risk. The objective of this study is to assess the prevalence of inadequate vitamin D status in European women aged over 80 years. Assessments of serum 25-hydroxyvitamin D levels (25(OH)D) were performed on 8532 European women with osteoporosis or osteopenia of which 1984 were aged over 80 years. European countries included in the study were: France, Belgium, Denmark, Italy, Poland, Hungary, United Kingdom, Spain and Germany. Two cut-offs of 25(OH)D inadequacy were fixed: <75 nmol/L (30 ng/ml) and <50 nmol/L (20 ng/ml). Mean (SD) age of the patients was 83.4 (2.9) years, body mass index was 25.0 (4.0) kg/m2 and level of 25(OH)D was 53.3 (26.7) nmol/L (21.4 [10.7] ng/ml). There was a highly significant difference of 25(OH)D level across European countries (p < 0.0001). In these women aged over 80 years, the prevalence of 25(OH)D inadequacy was 80.9% and 44.5% when considering cut-offs of 75 and 50 nmol/L, respectively. In the 397 (20.0%) patients taking supplemental vitamin D with or without supplemental calcium, the mean serum 25(OH)D level was significantly higher than in the other patients (65.2 (29.2) nmol/L vs. 50.3 (25.2) nmol/L; P < 0.001). This study indicates a high prevalence of vitamin D (25(OH)D) inadequacy in old European women. The prevalence could be even higher in some particular countries. [less ▲]

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See detailYBa2Cu3O7-δ thick films for magnetic shielding: Electrophoretic deposition from butanol-based suspension
Closset, Raphaël ULg; Kumar, Devendra; Wera, Laurent ULg et al

in Materials Letters (2014), 119

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common ... [more ▼]

Multilayered YBa2Cu3O7-δ (YBCO) thick films were coated on silver substrates by electrophoretic deposition (EPD) followed by heat treatment. A butanol-based YBCO suspension is used instead of the common acetone-iodine combination. Tests with several dispersing agents reveal that a branched polyethyleneimine (PEI) dispersant develops large positive surface charge on suspended YBCO particles. As a demonstration of the performance of this new suspension formulation, a 12-layer 100 μm-thick YBCO coating was deposited on an Ag tube. The superconducting transition is sharp with onset critical temperature at 92 K. The sample can shield a magnetic field of ~1.3 mT at 77 K, i.e., the best value so far for an YBCO coating on a metallic substrate. © 2013 Elsevier B.V. [less ▲]

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See detailAs Above, so Below: Narrative Salience and Side Effects of National Innovation Systems
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Critical Policy Studies (2014), accepté à publication

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See detailA ring system detected around the Centaur (10199) Chariklo
Braga-Ribas; Sicardy; Ortiz et al

in Nature (2014)

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See detailClinical variability in neurohepatic syndrome due to combined mitochondrial DNA depletion and Gaucher disease
HARVENGT, Julie ULg; wanty, catherine; De Paepe, Boel et al

in Molecular Genetics and Metabolism Reports (2014)

A one year old girl born to consanguineous parents presented with unexplained liver failure, leading to transplantation at 19 months. Subsequent partial splenectomy for persistent cytopenia showed the ... [more ▼]

A one year old girl born to consanguineous parents presented with unexplained liver failure, leading to transplantation at 19 months. Subsequent partial splenectomy for persistent cytopenia showed the presence of foamy cells, and Gaucher disease was confirmed by homozygosity for the p.Leu483Pro mutation in the GBA gene. She was treated by enzyme replacement therapy (ERT). Clinical follow-up showed mild developmental delay, strabism, nystagmus and oculomotor apraxia. Biochemical studies revealed multiple respiratory chain deficiencies and a mosaic pattern of deficient complex IV immunostaining in liver and fibroblast. Molecular analysis identified a mtDNA depletion syndrome due to the homozygous p.Pro98Leu mutation in MPV17. A younger sister unaffected by mtDNA depletion, presented with pancytopenia and hepatosplenomegaly. ERT for Gaucher disease resulted in visceral normalization, without any neurological symptom. A third sister, affected by both conditions, had marked developmental delay, strabism and ophthalmoplegia but no liver cirrhosis. In conclusion, intrafamilal variability occurs in MPV17 related disease. The combined pathological effect of Gaucher and mitochondrial diseases can negatively impact neurological and liver functions, and influence the outcome in consanguineous families. Immunocytochemical staining of OXPHOS protein in tissues and cultured cells is a powerful tool revealing mosaic pattern of deficiency pointing to mtDNA related mitochondrial disorders. [less ▲]

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See detailFinal Overall Survival: Fulvestrant 500 mg vs 250 mg in the Randomized CONFIRM Trial.
Leo, Angelo Di; Jerusalem, Guy ULg; Petruzelka, Lubos et al

in Journal of the National Cancer Institute (2014), 106(1), 337

BACKGROUND: At the time of the initial analysis of overall survival (OS) for the Comparison of Faslodex in Recurrent or Metastatic Breast Cancer (CONFIRM) randomized, double-blind, phase III trial ... [more ▼]

BACKGROUND: At the time of the initial analysis of overall survival (OS) for the Comparison of Faslodex in Recurrent or Metastatic Breast Cancer (CONFIRM) randomized, double-blind, phase III trial, approximately 50% of patients had died. A final analysis of OS was subsequently planned for when 75% of patients had died. METHODS: Patients were randomly assigned 1:1 to fulvestrant 500 mg administered as two 5-mL intramuscular injections on days 0, 14, and 28 and every 28 (+/-3) days thereafter or fulvestrant 250 mg administered as two 5-mL intramuscular injections (one fulvestrant and one placebo [identical in appearance to study drug]) on days 0, 14 (two placebo injections only), and 28 and every 28 (+/-3) days thereafter. OS was analyzed using an unadjusted log-rank test. No adjustments were made for multiplicity. Serious adverse events (SAEs) and best response to subsequent therapy were also reported. All statistical tests were two-sided. RESULTS: In total, 736 women (median age = 61.0 years) were randomly assigned to fulvestrant 500mg (n = 362) or 250mg (n = 374). At the final survival analysis, 554 of 736 (75.3%) patients had died. Median OS was 26.4 months for fulvestrant 500mg and 22.3 months for 250mg (hazard ratio = 0.81; 95% confidence interval = 0.69-0.96; nominal P = .02). There were no clinically important differences in SAE profiles between the treatment groups; no clustering of SAEs could be detected in either treatment group. Type of first subsequent therapy and objective responses to first subsequent therapy were well balanced between the two treatment groups. CONCLUSIONS: In patients with locally advanced or metastatic estrogen receptor-positive breast cancer, fulvestrant 500mg is associated with a 19% reduction in risk of death and a 4.1-month difference in median OS compared with fulvestrant 250mg. Fulvestrant 500mg was well tolerated, and no new safety concerns were identified. [less ▲]

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See detailThe anorectic effects of alpha-lipoicacid are mediated by central AMPK and are not due to taste aversion in chicken (Gallus gallus)
Wang, Y.; Song, Z.; Everaert, Nadia ULg et al

in Physiology & Behavior (2014), 132

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See detailLakeMIP Kivu: evaluating the representation of a large, deep tropical lake by a set of one-dimensional lake models
Thiery, Wim; Stepanenko, Victor M.; Fang, Xing et al

in Tellus : Series A (2014), 66

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See detailCompte rendu de Han BALTUSSEN, Michael ATKINSON, Michael SHARE, Ian MUELLER (trad.), Simplicius: On Aristotle Physics 1.5-9
Gavray, Marc-Antoine ULg

in International Journal of the Platonic Tradition (2014), 8(1), 115-117

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See detailMicro-Computed Tomography Based Computational Fluid Dynamics for the Determination of Shear Stresses in Scaffolds Within a Perfusion Bioreactor
Zermatten, Emilie; Vetsch, Jolanda Rita; Ruffoni, Davide ULg et al

in ANNALS OF BIOMEDICAL ENGINEERING (2014), 42(5), 1085-1094

Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous ... [more ▼]

Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk fibroin (SF) scaffold with an irregular network of interconnected pores. Their complex 3D geometries are imaged by micro-computed tomography and used in direct pore-level simulations of the entire scaffold-bioreactor system to numerically solve the governing mass and momentum conservation equations for fluid flow through porous media. The velocity field and wall shear stress distribution are determined for both scaffolds. The PCL scaffold exhibited an asymmetric distribution with peak and plateau, while the SF scaffold exhibited a homogenous distribution and conditioned the flow more efficiently than the PCL scaffold. The methodology guides the design and optimization of the scaffold geometry. [less ▲]

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See detailBone forming agents for the management of osteoporosis
Reginster, Jean-Yves ULg; Neuprez, A.; Beaudart, Charlotte ULg et al

in Panminerva medica (2014), 56(2), 97-114

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these ... [more ▼]

Osteoporotic fractures are a major cause of morbidity in the population. Anti-resorptive agents have been, for more than 15 years, the mainstay of osteoporosis treatment worldwide. However, these medications provide only limited fracture reduction and may be linked to skeletal and non-skeletal long-term safety concerns. Therefore, some patients are considered candidates for bone-forming agents because they remain severely osteoporotic or because they failed antiresorptive therapy. Over the last decade, a particular interest was shown in the developmentofmedicationsabletoincreaseosteoblastsnumber,lifespan or activity, hence stimulating bone formation Peptides from the parathyroid hormone family and strontium ranelate were shown to significantly reduce fracture rates but strontium ranelate is no longer an option for treating osteoporosis because of its safety profile. New therapeutic options, including monoclonal antibodies against sclerostin seem to be promising but their role in the armamentarium of osteoporosis will depend on the results of the current phase 3 studies, assessing antifracture efficacy and long-term safety. [less ▲]

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See detailThe retirement of the migrant labor force: pension portability and beyond
Jousten, Alain ULg

in CESifo Economic Studies (2014)

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – ... [more ▼]

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – system sustainability or distributive characteristics. The present paper provides a fresh look at the nexus between these two literatures. It discusses the impact of the European social security coordination mechanisms on individual decision-making and on the functioning of social security systems – with a focus on retirement. The paper argues that such effects are non-negligible and are likely to have major policy consequences. [less ▲]

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See detailThe Role of Memory Traces Quality in Directed Forgetting: A Comparison of Young and Older Participants
Collette, Fabienne ULg; Grandjean, Julien; Lorant, Caroline ULg et al

in Psychologica Belgica (2014), 54(4), 310-327

The presence of a reduced directed-forgetting (DF) effect in normal aging has been frequently observed with the item method. These results were interpreted as age-related difficulties in inhibiting the ... [more ▼]

The presence of a reduced directed-forgetting (DF) effect in normal aging has been frequently observed with the item method. These results were interpreted as age-related difficulties in inhibiting the processing of irrelevant information. However, since the performance of older adults is usually lower on items to remember, the age effect on DF abilities could also be interpreted as reflecting memory problems. Consequently, the present study aimed at investigating the influence of memory traces quality on the magnitude of the DF effects in normal aging. We predicted that increasing the quality of memory traces (by increasing presentation times at encoding) would be associated with attenuated DF effects in older participants due to the increased difficulty of inhibiting highly activated memory traces. A classical item-method DF paradigm was administered to 48 young and 48 older participants under short and long encoding conditions. Memory performance for information to memorize and to suppress was assessed with recall and recognition procedures, as well as with a Remember/Know/Guess (RKG) paradigm. The results indicated that, when memory traces are equated between groups, DF effects observed with the recall, recognition and RKG procedures are of similar amplitude in both groups (all ps>0.05). This suggests that the decreased DF effect previously observed in older adults might not actually depend on their inhibitory abilities but may rather reflect quantitative and qualitative differences in episodic memory functioning. [less ▲]

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See detailNeuronal and psychological underpinnings of pathological gambling
Singer, Bryan F.; Anselme, Patrick ULg; Robinson, Mike J.F. et al

in Frontiers in Behavioral Neuroscience (2014), 8, 230

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See detailIs dolphin morbillivirus virulent for white-beaked dolphins (Lagenorhynchus albirostris)?
van Elk, N.; van de Bildt, M.; Jauniaux, Thierry ULg et al

in Veterinary Pathology (2014)

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See detailDeltaNp63 isoform-mediated beta-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma.
Suarez-Carmona, Meggy ULg; Hubert, Pascale ULg; Gonzalez, Arnaud ULg et al

in Oncotarget (2014), sous presse

Beside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype ... [more ▼]

Beside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype in tumorigenesis is still confusing. Constitutively produced or induced in inflammatory conditions, human beta-defensins (HbetaDs) are cationic peptides involved in host defenses against bacteria, viruses and fungi. Here, we investigated both the role of p63 proteins in the regulation of HbetaDs and the implication of these antimicrobial peptides in tumor (lymph)angiogenesis. Thus, in contrast to TAp63 isotypes, we observed that DeltaNp63 proteins (alpha, beta, gamma) induce HbetaD1, 2 and 4 expression. Similar results were observed in cancer tissues and cell lines. We next demonstrated that DeltaNp63-overexpressing SCC are associated with both a poor prognosis and a high tumor vascularisation and lymphangiogenesis. Moreover, we showed that HbetaDs exert a chemotactic activity for (lymphatic) endothelial cells in a CCR6-dependent manner. The ability of HbetaDs to enhance (lymph)angiogenesis in vivo was also evaluated. We observed that HbetaDs increase the vessel number and induce a significant increase in relative vascular area compared to negative control. Taken together, the results of this study suggest that DeltaNp63-regulated HbetaD could promote tumor (lymph)angiogenesis in SCC microenvironment. [less ▲]

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See detailRemote sensing of colour, temperature and salinity – new challenges and opportunities
Alvera Azcarate, Aïda ULg; Ruddick, Kevin; Minnett, Peter

in Remote Sensing of Environment (2014), 146

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See detailSynthese bibliographique de l'influence du procédé d'extraction et de purification sur les caractéristiques et les propriétés d'une gomme de caroube
Gillet, Sébastien ULg; Simon, mathilde; Paquot, Michel ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2014), 18(1),

The carob tree is a species cultivated, in mediterranean countries, for its seeds. These seeds contain an endosperm rich in galactomannans used by the food industry for its texturing properties. After ... [more ▼]

The carob tree is a species cultivated, in mediterranean countries, for its seeds. These seeds contain an endosperm rich in galactomannans used by the food industry for its texturing properties. After harvesting, the seeds pass through a decutilation and a degermination. Cleaned endosperms are then milled to give crude locust bean gum. The purification step consists in a flour solubilization and then a precipitation of the galactomannans. Purification influences the characteristics of the resulting gum. The solubilization temperature is the parameter that affects the most on the final characteristics of the product. If it is hot or cold, galactomannans with different structural characteristics (and thus very different physical properties in aqueous solutions) will be selected. [less ▲]

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See detailOutcomes of adults with active or progressive hematological malignancies at time of allogeneic stem cell transplantation : a survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Chevallier, P.; Labopin, M.; Milpied, N. et al

in Bone Marrow Transplantation (2014), 49

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective ... [more ▼]

Previous data suggested that allo-SCT might be an effective therapy in the setting of chemo-refractory/relapsed diseases because of the potent long-term immune-mediated tumor control. This retrospective study aimed to analyze the outcome of adult patients who received allo-SCT in a chemo-refractory/relapsed status. The series included 840 patients with active or progressive disease at the time of transplant. Median age was 50 years. With a median follow-up of 40 months, 3-year OS, disease-free survival (DFS), and non-relapse mortality rates were 29±2, 23±2, and 30±2%, respectively. At the last follow-up, 252 patients (30%) were still alive (of whom 201 were in CR (24%). In a Cox multivariate analysis, the use of a reduced-intensity conditioning (RIC) before allo-SCT and use of an HLA-identical sibling donor remained independently associated with a better OS (hazard ratio (HR)¼0.82; 95% confidence interval (CI), 0.69–0.98, P¼0.03; and HR¼0.79; 95% CI, 0.66–0.93, P¼0.006, respectively). Also, a diagnosis of myelodysplastic syndrome/myeloproliferative disorder, Hodgkin lymphoma and non-Hodgkin lymphoma compared with acute leukemia had a favorable impact on OS (HR¼0.55; 95% CI, 0.45–0.68, Po0.0001; HR¼0.49; 95% CI, 0.31–0.75, P¼0.001; and HR¼0.47; 95% CI, 0.35–0.63, Po0.0001, respectively). In conclusion, this study suggests that allo-SCT may be of benefit in some subgroups of patients with active or progressive hematological malignancies at the time of allo-SCT. [less ▲]

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See detailWhat is Africa to me now?
Ledent, Bénédicte ULg; Tunca, Daria ULg

in Transition (2014), 113

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See detailImpact of anisotropy and viscosity to model the mechanical behavior of Ti-6Al-4V alloy
Tuninetti Vásquez, Victor ULg; Habraken, Anne ULg

in Materials Science and Engineering: A (2014)

This paper compares the predictions of an isotropic-thermo-elasto-viscoplastic approach and of an anisotropic-thermo-elastoplastic one with experimental results representative of the mechanical behavior ... [more ▼]

This paper compares the predictions of an isotropic-thermo-elasto-viscoplastic approach and of an anisotropic-thermo-elastoplastic one with experimental results representative of the mechanical behavior of Ti-6Al-4V at moderate temperatures and low strain rates. The first model is the well known Norton-Hoff viscoplastic constitutive law with isotropic von Mises yield locus identified by using monotonic tension tests performed at strain rates from 10-3 s-1 to 10-1 s-1 and at temperatures up to 400°C. The second model is a thermo-elasto-plastic one defined by the orthotropic yield criterion CPB06. It takes into account the anisotropy and the strength differential (SD) effect in tension-compression of Ti-6Al-4V at RT, 150°C and 400°C. The identification of the SD effect is done by using tension and compression tests and the anisotropy behavior is identified by using shear, plane strain, tension and compression tests performed in three orthogonal material directions. The accuracy of the load and displacements predictions of the two macroscopic constitutive models are compared to experimental results obtained from tests performed on specimens with multiaxial loadings and large strain at several temperatures. [less ▲]

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