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See detailManagement of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS and SIOG.
HADJI, P.; AAPRO, M.S.; BODY, J.J. et al

in Journal of Bone Oncology (2017), 23(7), 1-12

Background: Several guidelines have been reported for bone-directed treatment in women with early breast cancer (EBC) for averting fractures, particularly during aromatase inhibitor (AI) therapy. Recently ... [more ▼]

Background: Several guidelines have been reported for bone-directed treatment in women with early breast cancer (EBC) for averting fractures, particularly during aromatase inhibitor (AI) therapy. Recently, a number of studies on additional fracture related risk factors, new treatment options as well as real world studies demonstrating a much higher fracture rate than suggested by randomized clinical controlled trials (RCTs). Therefore, this updated algorithm was developed to better assess fracture risk and direct treatment as a position statement of several interdisciplinary cancer and bone societies involved in the management of AI-associated bone loss (AIBL). Patients and methods: A systematic literature review identified recent advances in the management of AIBL. Results with individual agents were assessed based on trial design, size, follow-up, and safety. Results: Several fracture related risk factors in patients with EBC were identified. Although, the FRAX algorithm includes fracture risk factors (RF) in addition to BMD, it does not seem to adequately address the effects of AIBL. Several antiresorptive agents can prevent and treat AIBL. However, concerns regarding compliance and longterm safety remain. Overall, the evidence for fracture prevention is strongest for denosumab 60 mg s.c. every 6 months. Additionally, recent studies as well as an individual patient data meta-analysis of all available randomized trial data support additional anticancer benefits from adjuvant bisphosphonate treatment in postmenopausal women with a 34% relative risk reduction in bone metastasis and 17% relative risk decrease in breast cancer mortality that needs to be taken into account when advising on management of AIBL. Conclusions: In all patients initiating AI treatment, fracture risk should be assessed and recommendation with regard to exercise and calcium/vitamin D supplementation given. Bone-directed therapy should be given to all patients with a T-score<−2.0 or with a T-score of<–1.5 SD with one additional RF, or with ≥2 risk factors (without BMD) for the duration of AI treatment. Patients with T-score>−1.5 SD and no risk factors should be managed based on BMD loss during the first year and the local guidelines for postmenopausal osteoporosis. Compliance should be regularly assessed as well as BMD on treatment after 12 - 24 months. Furthermore, because of the decreased incidence of bone recurrence and breast cancer specific mortality, adjuvant bisphosphonates are recommended for all postmenopausal women at significant risk of disease recurrence. [less ▲]

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See detailDe l’information (légale) à l'action (illégale) : Tests génétiques et technologies de pouvoir
Fallon, Catherine ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2017)

sur la base de l’étude des transformations technologiques récentes en matière de tests génétiques prénataux, ce texte propose une analyse comparée de l’évolution de ces dispositifs et des pratiques en ... [more ▼]

sur la base de l’étude des transformations technologiques récentes en matière de tests génétiques prénataux, ce texte propose une analyse comparée de l’évolution de ces dispositifs et des pratiques en Belgique et en Argentine. Les mêmes techniques et les mêmes connaissances sont disponibles dans les deux pays, que ce soit en matière de dépistage prénatal ou d’avortement médicamenteux, mais les conditions normatives, économiques, sociales et culturelles sont très différentes dans les deux pays. La prise en charge par les programmes publics médicaux assure un suivi « émancipateur » aux couples belges pendant la grossesse. En Argentine, où le recours à l'avortement légal est très restrictif, le dispositif public de dépistage prénatal reste inachevé. Dans les deux pays, il est possible de comparer comment ces dispositifs de « biopolitique » sont transformés par les innovations technologiques au niveau des réseaux de savoir et des relations de pouvoir entre l’état, le corps médical et les familles. Dans un tel cadre, la question de l’illégalité est moins centrale que l’étude de la normativité émergente [less ▲]

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See detailLésions mixtes des mâchoires, radio-opaques et radio-transparentes
MILICEVIC, Mladen ULiege

in Revue Médicale de Liège (2017), 72(3), 151-155

Les Lésions néoplasiques et non néoplasiques des mâchoires sont généralement classifiées comme radio-opaques ou radio-transparentes, odontogènes ou non odontogènes. Toutefois, il existe un nombre ... [more ▼]

Les Lésions néoplasiques et non néoplasiques des mâchoires sont généralement classifiées comme radio-opaques ou radio-transparentes, odontogènes ou non odontogènes. Toutefois, il existe un nombre significatif de pathologies qui peuvent être classifiées comme étant mixtes ou qui, au départ, sont radio-transparentes et deviennent ultérieurement radio-opaques ou mixtes. certaines pathologies s'expriment en différents stades de développement qui sont radio-transparents, radio-opaques ou mixtes. Le but de cet article est d'apporter une meilleure compréhension de l'imagerie de ces lésions, fondée sur une revue de la littérature, illustrée par des images de cas cliniques personnels. [less ▲]

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See detailComment les vidéastes gagnent-ils leur vie sur Youtube ?
Krywicki, Boris ULiege

in Culture, le Magazine Culturel de l'Université de Liège (2017)

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See detailInactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 cells by a multiplex CRISPR/Cas9 strategy results in glycoproteins without plant-specific glycans
Mercx, Sébastien; Smargiasso, Nicolas ULiege; Chaumont, François et al

in Frontiers in Plant Science (2017), 8

Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with planttypical residues [β(1,2)-xylose and core α(1,3 ... [more ▼]

Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with planttypical residues [β(1,2)-xylose and core α(1,3)-fucose], which can greatly impact the immunogenicity, allergenicity, or activity of the protein. Two enzymes are responsible for the addition of plant-specific glycans: β(1,2)-xylosyltransferase (XylT) and α(1,3)- fucosyltransferase (FucT). Our aim consisted of knocking-out two XylT genes and four FucT genes (12 alleles altogether) in Nicotiana tabacum BY-2 suspension cells using CRISPR/Cas9. Three XylT and six FucT sgRNAs were designed to target conserved regions. After transformation of N. tabacum BY-2 cells with genes coding for sgRNAs, Cas9, and a selectable marker (bar), transgenic lines were obtained and their extracellular as well as intracellular protein complements were analyzed by Western blotting using antibodies recognizing β(1,2)-xylose and α(1,3)-fucose. Three lines showed a strong reduction of β(1,2)-xylose and α(1,3)-fucose, while two lines were completely devoid of them, indicating complete gene inactivation. The absence of these carbohydrates was confirmed by mass spectrometry analysis of the extracellular proteins. PCR amplification and sequencing of the targeted region indicated small INDEL and/or deletions between the target sites. The KO lines did not show any particular morphology and grew as the wild-type. One KO line was transformed with genes encoding a human IgG2 antibody. The IgG2 expression level was as high as in a control transformant which had not been glycoengineered. The IgG glycosylation profile determined by mass spectrometry confirmed that no β(1,2)-xylose or α(1,3)-fucose were present on the glycosylation moiety and that the dominant glycoform was the GnGn structure. These data represent an important step toward humanizing the glycosylation of pharmacological proteins expressed in N. tabacum BY-2 cells. © 2017 Mercx, Smargiasso, Chaumont, De Pauw, Boutry and Navarre. [less ▲]

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See detailFlux penetration in a superconducting film partially capped with a conducting layer
Brisbois, Jérémy ULiege; Gladilin, V. N.; Tempere, J. et al

in Physical Review B (2017), 95

The influence of a conducting layer on the magnetic flux penetration in a superconducting Nb film is studied by magneto-optical imaging. The metallic layer partially covering the superconductor provides ... [more ▼]

The influence of a conducting layer on the magnetic flux penetration in a superconducting Nb film is studied by magneto-optical imaging. The metallic layer partially covering the superconductor provides an additional velocity-dependent damping mechanism for the flux motion that helps protecting the superconducting state when thermomagnetic instabilities develop. If the flux advances with a velocity slower than w = 2/µ0σt, where σ is the cap layer conductivity and t is its thickness, the flux penetration remains unaffected, whereas for incoming flux moving faster than w, the metallic layer becomes an active screening shield. When the metallic layer is replaced by a perfect conductor, it is expected that the flux braking effect will occur for all flux velocities. We demonstrate this effect by investigating Nb samples with a thickness step. Some of the observed features, namely the deflection and the branching of the flux trajectories at the border of the thick centre, as well as the favoured flux penetration at the indentation, are reproduced by time-dependent Ginzburg-Landau simulations. [less ▲]

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See detailSwitching Costs in Two-sided Markets
Lam, Wing Man Wynne ULiege

in Journal of Industrial Economics (2017), 65(1), 136-182

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See detailLe projet sémiologique de Barthes dans la revue Communications
Lorent, Fanny ULiege; Franck, Thomas ULiege

in Revue Roland Barthes (2017), 3

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See detailImpact of climate change on potential evapotranspiration under a historical and future climate scenario in the Huang-Huai-Hai Plain, China
Liu, Qin; Yan, Changrong; Ju, Hui et al

in Theoretical & Applied Climatology (2017)

Climate change is widely accepted to be one of the most critical problems faced by the Huang-Huai-Hai Plain (3H Plain), which is a region in which there is an over-exploitation of groundwater region and ... [more ▼]

Climate change is widely accepted to be one of the most critical problems faced by the Huang-Huai-Hai Plain (3H Plain), which is a region in which there is an over-exploitation of groundwater region and where future warmer and drought conditions might intensify crop water demand. In this study, the spatiotemporal patterns of ET0 and primary driving meteorological variables were investigated based on a historical and RCP 8.5 scenario daily data set from 40 weather stations over the 3H Plain using linear regression, spline interpolation method, a partial derivative analysis and multivariate regression. The results indicated a negative trend in all the analysis periods (except spring) of the past 54 years of which only summer and the entire year were statistically significant (p < 0.01) with slopes of -1.09 and -1.30 mm·a-1 respectively. In contrast, a positive trend was observed in all four seasons and the entire year under the RCP 8.5 scenario, with the biggest increment equal to 1.36 mm·a-1 in summer and an annual increment of 3.37 mm·a-1. The spatial patterns of the seasonal and annual ET0 exhibited the lowest values in southeastern regions and the highest values in northeastern parts of Shandong Province, probably because of the combined effects of various meteorological variables over the past 54 years. Relative humidity (RH) together with solar radiation (RS) were detected to be the main climatic factors controlling the reduction of ET0 in summer, autumn, and the entire year on the 3H Plain. ET0 in spring was mainly sensitive to changes in RS and RH, whereas ET0 in winter was most sensitive to changes in wind speed (WS) and decreased due to declining RH. Under the future RCP 8.5 scenario, the annual ET0 distribution displays a rich spatial structure with a clear northeast-west gradient and anarea with low values in the southern regions, which is similarly detected in spring and summer. The most sensitive and primary controlling variables with respect to the increment of future ET0 are in the first place RS and then mean temperature in spring, while turn to be mean temperature and then RS in summer. In autumn, future ET0 is most sensitive to RH changes. WS and RH are the controlling variables for ET0 in winter. Annual future ET0 is most sensitive to RH changes and accordingly RS is responsible for the predicted increment of the annual ET0. Better understanding of current and future spatiotemporal patterns of ET0 and of the regional response of ET0 to climate change can contribute to the establishment of a policy to realize a more efficient use of water resources and a sustainable agricultural production in the 3H Plain. [less ▲]

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See detailUltrasonic spray pyrolysis as a processing route for templated electrochromic tungsten oxide films
Chatzikyriakou, Dafni ULiege; Maho, Anthony ULiege; Cloots, Rudi ULiege et al

in Microporous and Mesoporous Materials (2017), 240

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See detailLocal Identification of Voltage Instability from Load Tap Changer Response
Weckesser, Johannes ULiege; Papangelis, Lampros ULiege; Vournas, Costas et al

in Sustainable Energy, Grids and Networks (2017)

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations ... [more ▼]

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations (eLIVES) method is a significantly modified version of the previously presented LIVES method. The new method is not bound to assessing system response over a predefined LTC tapping period. This allows handling LTCs with variable delays, as well as events taking place during the tapping sequence impacting the distribution voltages. For that purpose, eLIVES applies recursive least square fitting to acquired distribution voltage measurements and a new set of rules to detect a voltage emergency situation. The effectiveness of the eLIVES method is presented on the IEEE Nordic test system for voltage stability and security assessment. [less ▲]

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See detailHow the reference values for serum parathyroid hormone concentration are (or should be) established?
Souberbielle, J.-C.; Brazier, F.; Piketty, M.-L. et al

in Journal of Endocrinological Investigation (2017), 40(3), 241-256

Well-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria ... [more ▼]

Well-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria for this population can be defined as any situation possibly inducing an increase or a decrease in PTH concentration. As recommended in the recent guidelines on the diagnosis and management of asymptomatic primary hyperparathyroidism, PTH reference values should be established in vitamin D-replete subjects with a normal renal function with possible stratification according to various factors such as age, gender, menopausal status, body mass index, and race. A consensus about analytical/pre-analytical aspects of PTH measurement is also needed with special emphasis on the nature of the sample (plasma or serum), the time and the fasting/non-fasting status of the blood sample. Our opinion is that blood sample for PTH measurement should be obtained in the morning after an overnight fast. Furthermore, despite longer stability of the PTH molecule in EDTA plasma, we prefer serum as it allows to measure calcium, a prerequisite for a correct interpretation of a PTH concentration, on the same sample. Once a consensus is reached, we believe an important international multicentre work should be performed to recruit a very extensive reference population of apparently healthy vitamin D-replete subjects with a normal renal function in order to establish the PTH normative data. Due to the huge inter-method variability in PTH measurement, a sufficient quantity of blood sample should be obtained to allow measurement with as many PTH kits as possible. [less ▲]

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See detailConstraining the efficiency of angular momentum transport with asteroseismology of red giants: the effect of stellar mass
Eggenberger, P.; Lagarde, N.; Miglio, A. et al

in Astronomy and Astrophysics (2017), 599

Context: Constraints on the internal rotation of red giants are now available thanks to asteroseismic observations. Preliminary comparisons with rotating stellar models indicate that an undetermined ... [more ▼]

Context: Constraints on the internal rotation of red giants are now available thanks to asteroseismic observations. Preliminary comparisons with rotating stellar models indicate that an undetermined additional process for the internal transport of angular momentum is required in addition to purely hydrodynamic processes. Aims: We investigate how asteroseismic measurements of red giants can help us characterize the additional transport mechanism. Methods: We first determine the efficiency of the missing transport mechanism for the low-mass red giant KIC 7341231 by computing rotating models that include an additional viscosity corresponding to this process. We then discuss the change in the efficiency of this transport of angular momentum with the mass, metallicity and evolutionary stage. Results: In the case of the low-mass red giant KIC 7341231, we find that the viscosity corresponding to the additional mechanism is constrained to the range 1 x 10^3 - 1.3 x 10^4 cm^2/s. This constraint on the efficiency of the unknown additional transport mechanism during the post-main sequence is obtained independently of any specific assumption about the modelling of rotational effects during the pre-main sequence and the main sequence (in particular, the braking of the surface by magnetized winds and the efficiency of the internal transport of angular momentum before the post-main-sequence phase). When we assume that the additional transport mechanism is at work during the whole evolution of the star together with a solar-calibrated braking of the surface by magnetized winds, the range of nu_add is reduced to 1 - 4 x 10^3 cm^2/s. In addition to being sensitive to the evolutionary stage of the star, we show that the efficiency of the unknown process for internal transport of angular momentum increases with the stellar mass. [less ▲]

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See detailComparison of local outliers detection techniques in spatial multivariate data
Ernst, Marie ULiege; Haesbroeck, Gentiane ULiege

in Data Mining & Knowledge Discovery (2017), 31(2), 371399

Outlier detection techniques in spatial data should allow to identify two types of outliers: global and local ones. Local outliers typically have non-spatial attributes that strongly differ from those ... [more ▼]

Outlier detection techniques in spatial data should allow to identify two types of outliers: global and local ones. Local outliers typically have non-spatial attributes that strongly differ from those observed on their neighbors. Detecting local outliers requires to be able to work locally, on neighborhoods, in order to take into account the spatial dependence between the statistical units under consideration, even though the outlyingness is usually measured on the non-spatial variables. Many procedures have been outlined in the literature, but their number reduces when one wants to deal with multivariate non-spatial attributes. In this paper, focus is on the multivariate context. A review of existing procedures is done. A new approach, based on a two-step improvement of an existing one, is also designed and compared with the benchmarked methods by means of examples and simulations. [less ▲]

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See detailTraite robotisée, grands troupeaux et pâturage: retour d'expérience de 2 exploitations en Belgique
Lessire, Françoise ULiege; Knoden, David; Dufrasne, Isabelle ULiege

in Fourrages (2017), 229

La technique de traite robotisée entraîne dans bon nombre de cas l’abandon du pâturage ou, du moins, une forte diminution de la part d’herbe pâturée dans la ration des vaches laitières. Cet article montre ... [more ▼]

La technique de traite robotisée entraîne dans bon nombre de cas l’abandon du pâturage ou, du moins, une forte diminution de la part d’herbe pâturée dans la ration des vaches laitières. Cet article montre qu’il est possible de concilier traite robotisée, pâturage et grands troupeaux tout en gardant de bonnes performances économiques. [less ▲]

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See detailExperimental Correction of Radiation Patterns Between Electromagnetic Environments
Spirlet, Maxime ULiege; Geuzaine, Christophe ULiege; Beauvois, Véronique ULiege

in IEEE Transactions on Antennas & Propagation (2017), 65(03),

This manuscript presents an experimental method to estimate a radiation pattern obtained in a particular echoic environment (for example from in-situ measurements) as if measurements were performed in a ... [more ▼]

This manuscript presents an experimental method to estimate a radiation pattern obtained in a particular echoic environment (for example from in-situ measurements) as if measurements were performed in a given anechoic chamber. The correction is achieved using some reference measurements collected both in echoic and anechoic environments. An angular transfer function is estimated from these two sets of measurements and deconvolved from the measured radiation pattern to be corrected. [less ▲]

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See detailNutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
Beaudart, Charlotte ULiege; Dawson, A.; Shaw, S. C. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2017), 28(6), 1817-33

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise ... [more ▼]

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be limited. INTRODUCTION: In 2013, Denison et al. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people. They concluded that further studies were needed to provide evidence upon which public health and clinical recommendations could be based. The purpose of the present work was to update the prior systematic review and include studies published up to October 2015. METHODS: Using the electronic databases MEDLINE and EMBASE, we identified RCTs which assessed the combined effect of exercise training and nutritional supplementation on muscle strength, muscle mass, or physical performance in subjects aged 60 years and over. Study selection and data extraction were performed by two independent reviewers. RESULTS: The search strategy identified 21 additional RCTs giving a total of 37 RCTs. Studies were heterogeneous in terms of protocols for physical exercise and dietary supplementation (proteins, essential amino acids, creatine, beta-hydroxy-beta-methylbuthyrate, vitamin D, multi-nutrients, or other). In 79% of the studies (27/34 RCTs), muscle mass increased with exercise but an additional effect of nutrition was only found in 8 RCTs (23.5%). Muscle strength increased in 82.8% of the studies (29/35 RCTs) following exercise intervention, and dietary supplementation showed additional benefits in only a small number of studies (8/35 RCTS, 22.8%). Finally, the majority of studies showed an increase of physical performance following exercise intervention (26/28 RCTs, 92.8%) but interaction with nutrition supplementation was only found in 14.3% of these studies (4/28 RCTs). CONCLUSION: Physical exercise has a positive impact on muscle mass and muscle function in healthy subjects aged 60 years and older. The biggest effect of exercise intervention, of any type, has been seen on physical performance (gait speed, chair rising test, balance, SPPB test, etc.). We observed huge variations in regard to the dietary supplementation protocols. Based on the included studies, mainly performed on well-nourished subjects, the interactive effect of dietary supplementation on muscle function appears limited. [less ▲]

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See detailUnified treatment of boundary conditions and efficient algorithms for estimating tangent operators of the homogenized behavior in the computational homogenization method
Nguyen, Van Dung ULiege; Wu, Ling ULiege; Noels, Ludovic ULiege

in Computational Mechanics (2017), 59(3), 483-505

This work provides a unified treatment of arbitrary kinds of microscopic boundary conditions usually considered in the multi-scale computational homogenization method for nonlinear multi-physics problems ... [more ▼]

This work provides a unified treatment of arbitrary kinds of microscopic boundary conditions usually considered in the multi-scale computational homogenization method for nonlinear multi-physics problems. An efficient procedure is developed to enforce the multi-point linear constraints arising from the microscopic boundary condition either by the direct constraint elimination or by the Lagrange multiplier elimination methods. The macroscopic tangent operators are computed in an efficient way from a multiple right hand sides linear system whose left hand side matrix is the stiffness matrix of the microscopic linearized system at the converged solution. The number of vectors at the right hand side is equal to the number of the macroscopic kinematic variables used to formulate the microscopic boundary condition. As the resolution of the microscopic linearized system often follows a direct factorization procedure, the computation of the macroscopic tangent operators is then performed using this factorized matrix at a reduced computational time. [less ▲]

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See detailTrypanosomiasis challenge estimation using the diminazene aceturate (Berenil) index in Zebu in Gabon.
COSSIC, Brieuc; ADJAHOUTONON, B; GLOAGUEN, P et al

in Tropical Animal Health and Production (2017), 49(3), 619-624

A longitudinal study was conducted within a cattle ranch in Gabon to determine the diminazene aceturate (Berenil) index (DAI) in a group of Zebu, raised under low tsetse density; this measure providing an ... [more ▼]

A longitudinal study was conducted within a cattle ranch in Gabon to determine the diminazene aceturate (Berenil) index (DAI) in a group of Zebu, raised under low tsetse density; this measure providing an assessment of trypanosomiasis risk. The objective was to evaluate the trypanosomiasis pressure thus informing trypanosomiasis control methods and cattle management. Twenty female adult Zebu were monitored for 24 weeks during the dry season. Blood samples were collected on aweekly basis and subjected to parasitological and haematological analysis (n = 480), using the buffy-coat method and the packed cell volume value (PCV), respectively, infected animals were treated with a single intramuscular injection of diminazene aceturate (8 mg/kg). Twenty-nine single infectious events were recorded and a DAI of 1.45 was calculated. Two trypanosome species were identified: Trypanosoma congolense (96.2%) and Trypanosoma vivax (3.8%). The mean PCV value of the infected animals was lower (26.6) compared to non-infected animals (32.0). This study shows that DAI may be a useful tool to assess trypanosomiasis. However, this is a time-consumingmethod that may be improved by using randomly selected sentinel animals to adapt the chemoprophylactic schemes, hence decreasing the costs and the drug resistance risk. [less ▲]

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See detailDifferentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment.
Saengnipanthkul, Sukit; Waikakul, Saranatra; Rojanasthien, Sattaya et al

in International Journal of Rheumatic Diseases (2017)

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and ... [more ▼]

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulfate (pCGS) formulation (Mylan). Glucosamine is widely available as glucosamine sulfate (GS) and glucosamine hydrochloride (GH) preparations that vary substantially in molecular form, pharmaceutical formulation and dose regimen. Only pCGS is given as a highly bioavailable once-daily dose (1500 mg), which consistently delivers the plasma levels of around 10 mumol/L required to inhibit interleukin-1-induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction. Careful consideration of the evidence base reveals that only pCGS reliably provides a moderate effect size on pain that is higher than paracetamol and equivalent to non-steroidal anti-inflammatory drugs (NSAIDs), while non-crystalline GS and GH fail to reach statistical significance for pain reduction. Chronic administration of pCGS has disease-modifying effects, with a reduction in need for total joint replacement lasting for 5 years after treatment cessation. Pharmacoeconomic studies of pCGS demonstrate long-term reduction in additional pain analgesia and NSAIDs, with a 50% reduction in costs of other OA medication and healthcare consultations. Consequently, pCGS is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression. Physician and patient education on the differentiation of pCGS from other glucosamine formulations will help to improve treatment selection, increase treatment adherence, and optimize clinical benefit in OA. [less ▲]

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See detailEnglish translation and validation of the SarQoL®, a quality of life questionnaire specific for sarcopenia
Beaudart, Charlotte ULiege; Edwards, Mark; Moss, Charlotte et al

in Age & Ageing (2017), 46(2), 271-7

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this ... [more ▼]

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this questionnaire, its translation and validation in other languages is necessary. Objective: the purpose of this study was therefore to translate the SarQoL® into English and validate the psychometric properties of this new version. Design: cross-sectional. Setting: Hertfordshire, UK. Subjects: in total, 404 participants of the Hertfordshire Cohort Study, UK. Methods: the translation part was articulated in five stages: (i) two initial translations from French to English; (ii) synthesis of the two translations; (iii) backward translations; (iv) expert committee to compare the backward translations with the original questionnaire and (v) pre-test. To validate the English SarQoL®, we assessed its validity (discriminative power, construct validity), reliability (internal consistency, test–retest reliability) and floor/ceiling effects. Results: the SarQoL® questionnaire was translated without any major difficulties. Results indicated a good discriminative power (lower score of quality of life for sarcopenic subjects, P = 0.01), high internal consistency (Cronbach’s alpha of 0.88), consistent construct validity (high correlations found with domains related to mobility, usual activities, vitality, physical function and low correlations with domains related to anxiety, self-care, mental health and social problems) and excellent test–retest reliability (intraclass coefficient correlation of 0.95, 95%CI 0.92–0.97). Moreover, no floor/ceiling has been found. Conclusions: a valid SarQoL® English questionnaire is now available and can be used with confidence to better assess the disease burden associated with sarcopenia. It could also be used as a treatment outcome indicator in research. [less ▲]

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See detailL'écriture théâtrale réaffirme le plateau comme espace symbolique
Delhalle, Nancy ULiege

in Alternatives Théâtrales (2017), (131),

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See detailEntandrophragma cylindricum (Sprague) Sprague (Meliaceae), une espèce ligneuse concurrentielle en Afrique centrale (synthèse bibliographique)
Tabi Eckebil, Paule ULiege; Verheggen, François ULiege; Doucet, Jean-Louis ULiege et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21(1), 80-97

Introduction. De nos jours, la gestion des ressources forestières ne se focalise plus sur l’exploitation exclusive du bois d’oeuvre, mais prend également en considération les produits forestiers non ... [more ▼]

Introduction. De nos jours, la gestion des ressources forestières ne se focalise plus sur l’exploitation exclusive du bois d’oeuvre, mais prend également en considération les produits forestiers non ligneux. Entandrophragma cylindricum (Sprague) Sprague, de son nom commercial « sapelli/sapele », de la famille des Meliaceae, illustre parfaitement cette situation. Le présent article fait un état de l’art des connaissances concernant E. cylindricum et présente quelques informations sur la chenille qui lui est inféodée. Littérature. Le sapelli est une des espèces ligneuses les plus exploitées d’Afrique centrale pour son bois d’oeuvre. Il est répandu dans la forêt dense humide semi-caducifoliée du domaine guinéo-congolais. C’est une espèce semi-héliophile, son mode de dispersion est anémochore et sa phénologie est régulière. Selon la sylviculture appliquée, sa croissance en diamètre peut atteindre jusque 0,82 cm par an. Cette essence est également l’hôte d’une espèce de chenille comestible riche en protéines, I. oyemensis Rougeot. Fortement appréciée par les populations locales, cette chenille fait également l’objet d’un commerce régional et international. Enfin, l’écorce du sapelli est reconnue pour son intérêt ethnobotanique, particulièrement en médecine traditionnelle. Conclusions. Les informations tirées de la littérature ont permis de mettre en évidence certaines lacunes relatives à l’écologie et au mode de reproduction de cette espèce et, ceci, en dépit de son importance pour le commerce du bois. De plus, les inconnues quant à la productivité et la saisonnalité des chenilles d’Imbrasia oyemensis sur cet arbre nécessitent de développer des recherches complémentaires pour garantir la durabilité de l’exploitation simultanée de la ressource ligneuse et non ligneuse et pour proposer des modes de gestion concertés entre exploitants industriels et populations locales. [less ▲]

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See detailUne courbe rentrante dans le contentieux administratif ? Quand le législateur veut éviter ou neutraliser l’annulation par le Conseil d’Etat
Pâques, Michel ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017-1

DOCTRINE La Faculté de droit de l’Université de Liège. Notes historiques succinctes, par Patrick Wautelet Gardez votre carte d’identité en poche, par Frédéric Bouhon Les illégalités que l’on ne voit pas ... [more ▼]

DOCTRINE La Faculté de droit de l’Université de Liège. Notes historiques succinctes, par Patrick Wautelet Gardez votre carte d’identité en poche, par Frédéric Bouhon Les illégalités que l’on ne voit pas : Enseignements tirés du droit de l’arbitrage, par Olivier Caprasse Les barèmes de rémunération : la périlleuse transition de l’âge à l’expérience pour éliminer la discrimination, par Jacques Clesse De l’information (légale) à l’action (illégale) : Tests génétiques et technologies de pouvoir, par Catherine Fallon « La madone et la putain » : Quand les stéréotypes de genres influencent la perception de la légalité des violences sexuelles et le traitement de la réaction sociale à l’égard des femmes, par Serge Garcet Les circulaires administratives fiscales illégales, par Luc Herve Le licenciement en cas de congé pour assistance à un proche gravement malade et de congé pour soins palliatifs : une inconstitutionnalité créée par la Cour constitutionnelle ? Par Fabienne Kéfer Des tribulations des actions possessoires : entre illégalité et inconstitutionnalité, par Pascale Lecocq Lorsque l’Union européenne réaffirme sa norme : la réponse par l’absurde aux craintes de ses citoyens ? Par Quentin Michel L’intervention de l’assureur dans le procès pénal : la défense de ton assuré tu assumeras ? Par Olivier Michiels Défaut de motivation formelle et droit administratif de la sécurité sociale : des illégalités à redécouvrir ? Par Hugo Mormont Une courbe rentrante dans le contentieux administratif ? Quand le législateur veut éviter ou neutraliser l’annulation par le Conseil d’État, par Michel Pâques Au nom de l’ordre pénitentiaire. L’impératif de sécurité, générateur d’illégalités ? Par Vincent Seron Quis custodiet ipsos custodies ? Libres propos sur les violations de la légalité couvertes, admises, entérinées ou commises par les cours suprêmes, par Nicolas Thirion The Dodd-Frank Bounty Program: Disclosing the Unknown (and Getting Handsomely Paid For It), par François vander Mensbrugghe La « discrimination à rebours » au sein du marché intérieur : une illégalité qu’il ne faut pas voir au niveau européen ? Par Pieter van Cleynenbreugel La transaction pénale : des illégalités visibilisées aux ill(n)égalités moins visibles, par Charlotte vanneste Illégalité et jugements étrangers, par Patrick Wautelet VIE DU DROIT Autour et alentours des Leçons inaugurales de la Faculté de droit, de science politique et de criminologie de l’Université de Liège, par Patrick Wautelet Du zéro-vivant au zéro-mort, par André Dumoulin Le notaire refuse, par Gabriel Rasson Décider ensemble ou vivre ensemble ? Quelques pas de danse sur un air de tango, par Frédéric Bouhon D’une victime à l’autre : Posture ou (im)posture victimaire ? Par Serge Garcet Pouvoir politique et audace des juges, par Geoffrey Grandjean Hommage à Didier Matray, par Olivier Caprasse, Didier Matray et Pascale Lecocq [less ▲]

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See detailInternational Osteoporosis Foundation and European Calcified Tissue Society working group. Recommendations for the screening of the adherence to oral bisphosphonates.
DIEZ-PEREZ, A; NAYLOR, K.E.; ABRAHAMSEN, B et al

in Osteoporosis International (2017), 28(3), 767-774

Summary: Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the ... [more ▼]

Summary: Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the clinician should reassess the adherence to the treatment and also other potential issues with the drug. Introduction: Low adherence to oral bisphosphonates is a common problem that jeopardizes the efficacy of treatment of osteoporosis. No clear screening strategy for the assessment of compliance is widely accepted in these patients. Methods: The International Osteoporosis Foundation and the European Calcified Tissue Society have convened a working group to propose a screening strategy to detect a lack of adherence to these drugs. The question to answer was whether the bone turnover markers (BTMs) PINP and CTX can be used to identify low adherence in patients with postmenopausal osteoporosis initiating oral bisphosphonates for osteoporosis. The findings of the TRIO study specifically address this question and were used as the basis for testing the hypothesis. Results: Based on the findings of the TRIO study, specifically addressing this question, the working group recommends measuring PINP and CTX at baseline and 3 months after starting therapy to check for a decrease above the least significant change (decrease of more than 38% for PINP and 56% for CTX). Detection rate for the measurement of PINP is 84%, for CTX 87% and, if variation in at least one is considered when measuring both, the level of detection is 94.5%. Conclusions: If a significant decrease is observed, the treatment can continue, but if no decrease occurs, the clinician should reassess to identify problems with the treatment, mainly low adherence. [less ▲]

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See detailCollecte in vivo d’ovocytes d’ânesses et chronologie de la maturation in vitro
Reigner, Fabrice; Barrière, Philippe; Blard, Thierry et al

in Pratique Vétérinaire Equine (2017), 49(193), 38-43

La plupart des espèces d’ânes sauvages et domestiques est en danger d’extinction. Leur préservation nécessite la cryoconservation du sperme, des ovocytes et des embryons. L’objectif de cette étude était ... [more ▼]

La plupart des espèces d’ânes sauvages et domestiques est en danger d’extinction. Leur préservation nécessite la cryoconservation du sperme, des ovocytes et des embryons. L’objectif de cette étude était de mettre au point une technique de collecte in vivo et de maturation in vitro des ovocytes d’ânesses. Les ovocytes ont été collectés par ponction folliculaire transvaginale sous guide échographique, placés dans un milieu de maturation in vitro pendant 24, 30, 34 ou 38 heures puis analysés. Quatre-vingt-douze ovocytes ont été collectés dans 193 follicules (48%) avec une moyenne de 4,2 ovocytes par ânesse. Après 34 heures de maturation in vitro, 45% des ovocytes ont été matures. Pour la première fois une technique de collecte in vivo et de maturation in vitro d’ovocytes d’ânesses a été développée. Cette technique permet d’envisager la cryoconservation et la fécondation in vitro de ces ovocytes. [less ▲]

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See detailPublic Health impact and economic evaluation of vitamin D-fortified dairy products for fracture prevention in France.
HILIGSMANN, M.; BURLET, N.; FARDELLONE, P. et al

in Osteoporosis International (2017), 28(3), 833-840

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French ... [more ▼]

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French population aged over 60 years. Introduction: This study aims to assess the public health and economic impact of vitamin D-fortified dairy products in the general French population aged over 60 years. Methods: We estimated the lifetime health impacts expressed in number of fractures prevented, life years gained, and quality-adjusted life years (QALY) gained of the recommended intake of dairy products in the general French population over 60 years for 1 year (2015). A validated microsimulation model was used to simulate three age cohorts for both women and men (60–69, 70–79, and >80 years). The incremental cost per QALY gained of vitamin D-fortified dairy products compared to the absence of appropriate intake was estimated in different populations, assuming the cost of two dairy products per day in base case. Results: The total lifetime number of fractures decreased by 64,932 for the recommended intake of dairy products in the general population over 60 years, of which 46,472 and 18,460 occurred in women and men, respectively. In particular, 15,087 and 4413 hip fractures could be prevented in women and men. Vitamin D-fortified dairy products also resulted in 32,569 QALYs and 29,169 life years gained. The cost per QALY gained of appropriate dairy intake was estimated at €58,244 and fall below a threshold of €30,000 per QALY gained in women over 70 years and in men over 80 years. Conclusion: Vitamin D-fortified dairy products have the potential to substantially reduce the burden of osteoporotic fractures in France and seem an economically beneficial strategy, especially in the general population aged above 70 years. [less ▲]

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See detailStructure impact of two galactomannan fractions on their viscosity properties in dilute solution, unperturbed state and gel state
Gillet, Sébastien; Aguedo, Mario ULiege; Petrut, Raoul et al

in International Journal of Biological Macromolecules (2017), 96

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See detailErnst Mach, psychologue de la forme ?
Zincq, Aurélien ULiege

in Philosophie (2017), 133

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See detailOptimization of DNA extraction from the Algerian traditional date’s product “Btana”
Abekhti, Abdel; Dgeghati, S.; Taminiau, Bernard ULiege et al

in Applied Biology in Saharan Areas (2017), 1(1), 23-32

Btana is traditional preservation method that can sustain date’s supply during many years in comparaison to the commercial storage methods. However no scientific informations are available about ... [more ▼]

Btana is traditional preservation method that can sustain date’s supply during many years in comparaison to the commercial storage methods. However no scientific informations are available about biological factors that contribute to the successful of this method. Bacterial communities are a major key in preservation of many foods. Culture independent techniques are the most powerful tools to enhance bacterial diversity studies, but their efficiencies start with DNA extraction step. Therefore we have studied 3 protocols of DNA extraction from 11 Btana samples to evaluate their yield in total microbial DNA recovery. Protocols were based on a commercial kit DNeasy (QIAGEN, Germany) and two modified CTAB extraction methods (combined CTAB-DNeasy protocol, modified CTAB protocol) using polyvinyl pyrrolidone (PVP) and treatment with high salt solution (5M NaCl). Protocols were compared for quantity of DNA extracted using NanoDrop® ND-1000 Spectrophotometer and quality of DNA by 260/280 nm absorption ratio. The total extracted DNA was cheeked by PCR amplification of the 16S rRNA and visualized by electrophoresis on agarose gel (0.8%). Results showed that CTAB modified method provide the best DNA yield; however purification with NucleoSpin® Kit (Clontech, UK) was mostly needed for amplifying the DNA template. DNeasy kit protocol gave an amplified high quality DNA, but poor yields were obtained from date samples [less ▲]

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See detailUn regard comparatif sur les régionalismes africain et latino-américain
Santander, Sébastian ULiege

in Interventions Economiques = Papers in Political Economy (2017)

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See detailFactors to be considered to perform a kinematic evaluation of the tennis serve
Tubez, François ULiege; Forthomme, Bénédicte ULiege; Croisier, Jean-Louis ULiege et al

in Journal of Medecine and Science in Tennis (2017), 22

With the 2D video cameras and later the appearance of 3D measurement methods, the tennis serve has been increasingly studied. In order to improve the biomechanical evaluation of the tennis serve. Our goal ... [more ▼]

With the 2D video cameras and later the appearance of 3D measurement methods, the tennis serve has been increasingly studied. In order to improve the biomechanical evaluation of the tennis serve. Our goal is to provide a comprehensive view of the major factors of an evaluation protocol. [less ▲]

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See detailThe Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action.
Ethgen, Olivier ULiege; Beaudart, Charlotte ULiege; Buckinx, Fanny ULiege et al

in Calcified Tissue International (2017), 100(3), 229-234

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected ... [more ▼]

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected burden of sarcopenia in the coming years. Age- and gender-specific population projections were retrieved until 2045 from the Eurostat online database (28 European countries). Age- and gender-specific prevalences of sarcopenia were interpolated from a study that compared prevalence estimates according to the different diagnostic cutoffs of the EWGSOP proposed definition. The reported prevalence estimates were interpolated between 65 and 100 years. Interpolated age- and gender-specific estimates of sarcopenia prevalence were then applied to population projections until 2045. Using the definition providing the lowest prevalence estimates, the number of individuals with sarcopenia would rise in Europe from 10,869,527 in 2016 to 18,735,173 in 2045 (a 72.4% increase). This corresponds to an overall prevalence of sarcopenia in the elderly rising from 11.1% in 2016 to 12.9% in 2045. With the definition providing the highest prevalence estimates, the number of individuals with sarcopenia would rise from 19,740,527 in 2016 to 32,338,990 in 2045 (a 63.8% increase), corresponding to overall prevalence rates in the elderly of 20.2% and 22.3% for 2016 and 2045, respectively. We showed that the number of sarcopenic patients will dramatically increase in the next 30 years, making consequences of muscle wasting a major public health issue. [less ▲]

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See detailInfection invasive a Streptocoque du groupe A dans le decours d'une scarlatine.
Warnier, H.; Depuis, Z.; NYAMUGABO MUNYERE NKANA, Kindja ULiege et al

in Revue Médicale de Liège (2017), 72(3), 132-138

Invasive Group A Streptococcus infections and streptococcal toxic shock syndrome are rare complications of common diseases in children such as scarlet fever or impetigo. These invasive diseases are ... [more ▼]

Invasive Group A Streptococcus infections and streptococcal toxic shock syndrome are rare complications of common diseases in children such as scarlet fever or impetigo. These invasive diseases are particulary challenging because of their rapid progression and the lack of predisposing factors in most cases. Prompt diagnosis and treatment are mandatory to reduce the mortality associated with these severe diseases. We report the case of an 8- year-old girl who developped an invasive group A streptococcal disease with osteomyelitis and streptococcal toxic shock syndrome in the course of a classical scarlet fever. [less ▲]

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See detailL'acte d'imagination: Approches phénoménologiques
Hagelstein, Maud ULiege; Hervy, Alievtina ULiege; Leclercq, Bruno ULiege

in Bulletin d'Analyse Phénoménologique (2017), 13 (2017)(2),

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte ... [more ▼]

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte d’imagination : approches phénoménologiques, vingt-huit chercheurs issus de vingt-deux universités différentes se sont rencontrés pendant une semaine entière pour discuter dans le détail plusieurs aspects de la problématique. Le volume actuel reprend la plupart des communications qui avaient été présentées durant cette semaine, communications ici retravaillées pour intégrer les propositions qu’avaient suscitées leur présentation originale et plus généralement l’ensemble des débats très riches qu’avait permis la constitution ponctuelle d’une vraie communauté philosophique. Kant avait notoirement fait de la faculté d’imagination un intermédiaire (un peu indécis) entre la réceptivité de l’expérience sensible et la spontanéité de l’entendement. En s’installant plus nettement sur le terrain de la psychologie descriptive et en abandonnant le vocabulaire des « facultés » pour lui préférer celui des actes mentaux ou des fonctions psychiques, les brentaniens s’étaient donné les moyens d’analyser plus finement les composantes de l’acte d’imagination (mode de visée, contenu réel, contenu intentionnel...), les rapports de fondation qu’il entretient avec d’autres types d’actes, et par là le rôle qu’il peut jouer dans les fonctions cognitives ou évaluatives de l’esprit. C’est de cet acte d’imagination, envisagé par la phénoménologie en tant que psychologie descriptive, qu’il sera ici question. [less ▲]

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See detailLa déprédation non aléatoire chez les oiseaux granivores du marais de Kagogo-Gisumo au Burundi
Nasasagare, Régine-Pacis; Ndayisaba, Ernest; Libois, Roland ULiege

in Bulletin scientifique sur l'environnement et la biodiversité (2017), 2

This study was conducted in order to show the role of environmental factors in the damage caused by birds on rice. In the Kagogo-Gisumo marsh, 20 plots were chosen randomly for a ornithological inventory ... [more ▼]

This study was conducted in order to show the role of environmental factors in the damage caused by birds on rice. In the Kagogo-Gisumo marsh, 20 plots were chosen randomly for a ornithological inventory and an evaluation of the losses due to the birds. This study revealed that environmental factors play an important role in bird damage to rice [less ▲]

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See detailMultivariate analysis of 18F-DMFP PET data to assist the diagnosis of parkinsonism
Segovia, Fermin; Gorriz, Juan M.; Ramirez, Javier et al

in Frontiers in Neuroinformatics (2017)

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See detailArtemisia campestris L.:Ethnomedical, phytochemical and pharmacological review
Dib, Ikram; Angenot, Luc ULiege; Ziyyat, Abderrahim et al

in Journal of Herbal Medicine (2017), 7(1), 1-10

Artemisia campestris is a perennial herb, commonly known as field wormwood. it is widespread in Asia, North America, Europe and north Africa. the different parts of this plant are used as anthelmintic ... [more ▼]

Artemisia campestris is a perennial herb, commonly known as field wormwood. it is widespread in Asia, North America, Europe and north Africa. the different parts of this plant are used as anthelmintic, antidiabetic, antihypertensive, emmenagogue, antivenom, and to treat digestive and cutaneous problems. an exhaustive bibliographic research of this plant has been carried out by means of scientific engines and databases like Google scholar, PubMed, Sciencedirect and sciFinder; as a result, it has been found that this herb possesses a rich phytochemical content and a wide range of pharmacological activities such as antioxidant, antibacterial, antimutagenic , antivenom and antitumor effects. In an aim to highlight the importance of A. campestris L., this review has been established by discussing its ethnomedicinal, morphological, ecological, phytochemical, pharmacological and toxicological studies. [less ▲]

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See detailScrutin proportionnel scrutin majoritaire
Verjans, Pierre ULiege; Matagne, Geoffroy ULiege; Counet, Maxime ULiege

in Politique revue belge d'analyse et de débats (2017), 98-99

Le scrutin proportionnel utilisé en Belgique produit des gouvernements de coalition où la recherche du compromis et du consensus est obligatoire tandis que le scrutin majoritaire utilisé en France produit ... [more ▼]

Le scrutin proportionnel utilisé en Belgique produit des gouvernements de coalition où la recherche du compromis et du consensus est obligatoire tandis que le scrutin majoritaire utilisé en France produit des gouvernements monopartisans qui tentent de transformer leur société par des mesures non négociées. Chaque mode de sélection a ses avantages. [less ▲]

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See detailGeneration of High-Amylose Rice through CRISPR/Cas9-Mediated Targeted Mutagenesis of Starch Branching Enzymes
Sun, Yongwei ULiege; Xia, Lanqin; Francis, Frédéric ULiege et al

in Frontiers in Plant Science (2017), 8

Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits. Previous studies using chemical mutagenesis or RNA interference have demonstrated that starch branching ... [more ▼]

Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits. Previous studies using chemical mutagenesis or RNA interference have demonstrated that starch branching enzyme (SBE) plays a major role in determining the fine structure and physical properties of starch. However, it remains a challenge to control starch branching in commercial lines. Here, we use CRISPR/Cas9 technology to generate targeted mutagenesis in SBEI and SBEIIb in rice. The frequencies of obtained homozygous or bi-allelic mutant lines with indels in SBEI and SBEIIb in T0 generation were from 26.7 to 40%. Mutations in the homozygous T0 lines stably transmitted to the T1 generation and those in the bi-allelic lines segregated in a Mendelian fashion. Transgene-free plants carrying only the frame-shifted mutagenesis were recovered in T1 generation following segregation. Whereas no obvious differences were observed between the sbeI mutants and wild type, sbeII mutants showed higher proportion of long chains presented in debranched amylopectin, significantly increased AC and RS content to as higher as 25.0% and 9.8%, respectively, and thus altered fine structure and nutritional properties of starch. Taken together, our results demonstrated for the first time the feasibility to create high-amylose rice through CRISPR/Cas9-mediated editing of SBEIIb. [less ▲]

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See detailFactors controlling the evolution of groundwater dynamics and chemistry in the Senegal River Delta
Gning, Abdoul Aziz; Orban, Philippe ULiege; Gesels, Julie ULiege et al

in Journal of Hydrology: Regional Studies (2017), 10

tStudy region: Senegal River Delta. Study focus: The Senegal River Delta is a strategic region for the development of irri-gated agriculture. Despite a Sahelian climatic context, the management of the ... [more ▼]

tStudy region: Senegal River Delta. Study focus: The Senegal River Delta is a strategic region for the development of irri-gated agriculture. Despite a Sahelian climatic context, the management of the river withdams ensures water availability throughout the year. With the intensification of agri-culture, degradation of cultivated soils is observed, mostly linked to the existence of ashallow salty aquifer. In this context, regional surveys were performed to characterizegroundwater–surface water interactions and to identify the impact of artificial river man-agement and agricultural intensification on the evolution of groundwater dynamics andchemistry.New hydrological insights for the region: Results show that groundwater far away from riversand outside irrigated plots has evolved from marine water to brines under the influenceof evapotranspiration. Near rivers, salinity of groundwater is lower than seawater andgroundwater mineralization seems to evolve in the direction of softening through cationicexchanges related to permanent contact with fresh water. Despite large volumes of waterused for rice cultivation, groundwater does not show any real softening trend in the culti-vated parcels. Results show that the mechanisms that contribute to repel salt water fromthe sediments correspond to a lateral flush near permanent surface water streams and notto vertical drainage and dilution with rainfall or irrigation water. It is however difficultto estimate the time required to come back to more favorable conditions of groundwatersalinity. [less ▲]

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See detailProteomic response of Macrobrachium rosenbergii hepatopancreas exposed to chlordecone: Identification of endocrine disruption biomarkers?
Lafontaine, Anne ULiege; Baiwir, Dominique ULiege; Joaquim-Justo, Célia ULiege et al

in Ecotoxicology and Environmental Safety (2017), 141

The present work is the first study investigating the impacts of chlordecone, an organochlorine insecticide, on the proteome of the decapod crustacean Macrobrachium rosenbergii, by gel-free proteomic ... [more ▼]

The present work is the first study investigating the impacts of chlordecone, an organochlorine insecticide, on the proteome of the decapod crustacean Macrobrachium rosenbergii, by gel-free proteomic analysis of the hepatopancreas protein expression variations in organisms exposed to three environmental relevant concentrations of chlordecone (i.e. 0.2, 2 and 20 μg/L). Results revealed that 62 proteins were significantly up- or down-regulated in exposed prawns compared to controls. Most of these proteins are involved in important physiological processes such as ion transport, defense mechanisms and immune system, cytoskeleton dynamics, or protein synthesis and degradation. Moreover, it appears that 6% of the deregulated protein are involved in the endocrine system and in the hormonal control of reproduction or development processes of M. rosenbergii (e.g. vitellogenin, farnesoic acid omethyltransferase). These results indicate that chlordecone is potentially an endocrine disruptor compound for decapods, as already observed in vertebrates. These protein modifications could lead to disruptions of growth and reproduction of M. rosenbergii, and therefore of the fitness population on the long-term. Besides, these disrupted proteins could be suggested as biomarkers of exposure for endocrine disruptions in invertebrates. However, further investigations are needed to complete understanding of action mechanisms of chlordecone on proteome and endocrine system of crustaceans. [less ▲]

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See detailQuel « PRP » pour traiter les tendinopathies chroniques ?
Kaux, Jean-François ULiege; Emonds-Alt, Thibault ULiege

in Journal de Traumatologie du Sport (2017), 34(1), 76-90

Plasma rich platelets (PRP) consist of blood plasma with a high concentration of platelets autologous constituting a huge reservoir of growthfactors. The clinical use of the PRP is widespread in various ... [more ▼]

Plasma rich platelets (PRP) consist of blood plasma with a high concentration of platelets autologous constituting a huge reservoir of growthfactors. The clinical use of the PRP is widespread in various medical applications. Even it is very popular with athletes, the use of PRP intendinopathies is still scientifically discussed, particularly related to a disparity in the products called PRP. In order to optimize employment, itshould be interested in the different stages of obtaining of the PRP. In this literature review, we analyzed in particular 8 parameters that can influencethe quality of the PRP: (1) anticoagulants used to preserve the best feature of platelet; (2) centrifuge speeds used in order to extract platelets; (3)platelet concentrations and the presence of leukocytes and erythrocytes in the PRP; (4) the platelet activators for the mast of platelets and thus therelease of growth factors; (5) use of local anesthetics to achieve infiltration, in addition to these parameters, it might be interesting to analyze othervariables like: (6) employment or not of buffer to neutralize the acidity caused by anticoagulants; (7) injection under US guidance or not; and (8)volume of PRP injected to determine their influence on the healing potential. [less ▲]

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See detailNéolibéralisme et politique de soins de santé
Guisset, AL; Dispas, H; Porignon, Denis ULiege

in Santé Conjuguée (2017), (78), 32-35

Qui oriente réellement les politiques de santé ? C’est la question posée à Denis Porignon et à Ann-Lise Guisset. Ils déclinent leur réponse à trois niveaux : global, national et individuel. Cet entretien ... [more ▼]

Qui oriente réellement les politiques de santé ? C’est la question posée à Denis Porignon et à Ann-Lise Guisset. Ils déclinent leur réponse à trois niveaux : global, national et individuel. Cet entretien, qui pose le décor et débusque certains travers de l’aide mondiale, sera suivi d’un second axé sur des initiatives et mécanismes correcteurs, à paraitre dans le prochain numéro de Santé conjuguée. [less ▲]

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See detailSeasonal plasticity of auditory saccular sensitivity in “sneaker” type II male plainfin midshipman fish, Porichthys notatus
Bhandiwad, Ashwin A.; Whitchurch, Elizabeth A.; Colleye, Orphal ULiege et al

in Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural and Behavioral Physiology (2017), 203(3), 211-222

Adult female and nesting (type I) male midshipman fish (Porichthys notatus) exhibit an adaptive form of auditory plasticity for the enhanced detection of social acoustic signals. Whether this adaptive ... [more ▼]

Adult female and nesting (type I) male midshipman fish (Porichthys notatus) exhibit an adaptive form of auditory plasticity for the enhanced detection of social acoustic signals. Whether this adaptive plasticity also occurs in “sneaker” type II males is unknown. Here, we characterize auditory-evoked potentials recorded from hair cells in the saccule of reproductive and non-reproductive “sneaker” type II male midshipman to determine whether this sexual phenotype exhibits seasonal, reproductive state-dependent changes in auditory sensitivity and frequency response to behaviorally relevant auditory stimuli. Saccular potentials were recorded from the middle and caudal region of the saccule while sound was presented via an underwater speaker. Our results indicate saccular hair cells from reproductive type II males had thresholds based on measures of sound pressure and acceleration (re. 1 μPa and 1 ms−2, respectively) that were ~8–21 dB lower than non-reproductive type II males across a broad range of frequencies, which include the dominant higher frequencies in type I male vocalizations. This increase in type II auditory sensitivity may potentially facilitate eavesdropping by sneaker males and their assessment of vocal type I males for the selection of cuckoldry sites during the breeding season. [less ▲]

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See detailThe origin of CIMP or how to increase international contacts between Paleozoic palynologists during the second part of last century.
Streel, Maurice ULiege

in Commission internationale de la microflore du Paléozoïque CIMP Newsletter (2017), 86

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See detailRendre compte de la société d’aujourd’hui
Quoilin, Cécile; Postula, Jean-Louis ULiege

in Cahiers de muséologie - Dans la marge (2017)

Founded a century ago as a classical museum of regional ethnography, the Museum of Walloon Life is now facing the challenge of an essential update and the redefinition of its museum project. For about ten ... [more ▼]

Founded a century ago as a classical museum of regional ethnography, the Museum of Walloon Life is now facing the challenge of an essential update and the redefinition of its museum project. For about ten years, the choice of the approach known as "society museum" on the occasion of the total renovation of the building, led to an in-depth review of the acquisition and exhibition policies but also of the nature of field research and relationships with its different audiences. This article shows the practical consequences of the implementation of this new model, which now places the man rather than the collections at the center of discourse, on all museum functions. One of its fundamental objectives is to allow the development within the Museum of the sometimes complex issues of contemporary society. [less ▲]

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See detailLA THÉRAPIE MANUELLE ORTHOPÉDIQUE : définition, caractéristiques et mise au point sur la situation en Belgique
Demoulin, Christophe ULiege; Depas, Yannick ULiege; Vanderthommen, Marc ULiege et al

in Revue Médicale de Liège (2017), 72(3), 126-131

Orthopaedic manual therapy : definition, characteristics and update on the situation in Belgium Summary : Although orthopaedic manual therapy (OMT) has existed for decades, and although a recent Belgian ... [more ▼]

Orthopaedic manual therapy : definition, characteristics and update on the situation in Belgium Summary : Although orthopaedic manual therapy (OMT) has existed for decades, and although a recent Belgian Royal Decree, published in 2014, recognized it as a particular professional qualification in physiotherapy for the treatment of neuromusculoskeletal dysfunctions, OMT remains little known by patients, but also by healthcare professionals. Yet, this professional qualification, based on clinical reasoning, using highly specific treatments, guided by the best available scientific and clinical evidence and the specific biopsychosocial characteristics of each patient, is the subject of a growing number of scientific studies pointing out its effectiveness. This article summarizes the knowledge related to OMT (definition, history, characteristics, techniques, indications, access and reimbursement) and describes its situation in Belgium. [less ▲]

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See detailEvaluation of different in vitro dissolution tests based on level A in vitro–in vivo correlations for fenofibrate self-emulsifying lipid-based formulations
Pestieau, Aude ULiege; Lebrun, Sonia; Cahay, Bernard et al

in European Journal of Pharmaceutics & Biopharmaceutics (2017), 112

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See detailAnalytical and clinical validation of the new Abbot Architect 25(OH)D assay: fit for purpose?
Cavalier, Etienne ULiege; LUKAS, Pierre ULiege; BEKAERT, Anne-Catherine ULiege et al

in Clinical Chemistry & Laboratory Medicine (2017), 55(3), 378-384

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated ... [more ▼]

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated immunoassays and against a VDSP-traceable liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in six different populations. We also supplemented 40 healthy volunteers with either 600,000 IU of vitamin D2 or 100,000 of vitamin D3 to evaluate the performance of the immunoassays vs. the LC-MS/MS. METHODS: Precision and limit of quantification were assessed, 25(OH)D2 and C3-epimer recovery were calculated. Two hundred and forty samples obtained in healthy Caucasians and Africans, osteoporotic, hemodialyzed and intensive care patients and 3rd trimester pregnant women were analyzed by all methods. Correlation was studied using Passing-Bablok and Bland-Altman analysis. Concordance correlation coefficient (CCC) was calculated to evaluate agreement between immunoassays and LC-MS/MS. We verified if patients were homogeneously classified with the immunoassays when they took vitamin D2 or vitamin D3 after 1, 7 and 28 days. RESULTS: We observed excellent analytical features and showed a very good correlation to the LC-MS/MS results in the overall population. Compared to the other immunoassays, concordance of the new Abbott assay with the LC-MS/MS was at least similar, and often better in diseased populations. Althought the cross-reactivity with 25(OH)D2 was not of 100%, there was no significant difference in the classifications of the patients, either supplemented with D2 or D3 or after 7 or 28 days. CONCLUSIONS: This modified version of the Abbott Architect assay is clearly improved compared to the previous one and presents a better agreement with the LC-MS/MS. [less ▲]

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See detailAccurate Control of 17beta-Estradiol Long-Term Release Increases Reliability and Reproducibility of Preclinical Animal Studies.
Gérard, Céline ULiege; Gallez, Anne ULiege; Dubois, Charline ULiege et al

in Journal of Mammary Gland Biology & Neoplasia (2017), 22(1), 1-11

Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to ... [more ▼]

Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to-use slow releasing devices to administer steroids, especially estrogens, to small experimental animals remains the method of choice in terms of animal well-being and of safety for both the researcher and the animal. In this study, we evaluated and compared, in vitro and in vivo, the release kinetic of estradiol (E2) over sixty days from two different slow-releasing systems: the matrix pellet (MP) and the reservoir implant (RI). We compared the impact of these systems in three E2-sensitive mouse models : mammary gland development, human MCF7 adenocarcinoma xenograft and mouse melanoma progression. The real amount of E2 that is released from both types of devices could differ from manufacturer specifications due to inadequate release for MP and initial burst effect for RI. Compared to MP, the interindividual variability was reduced with RI thanks to a superior control of the E2 release. Depending on the dose-dependent sensitivity of the physiological or pathological readout studied, this could lead to an improvement of the statistical power of in vivo experiments and thus to a reduction of the required animal number. Altogether, our data draw attention on the importance to adequately select the slow-releasing device that is the most appropriated to a specific experiment to better fulfill the 3Rs rule (Replacement, Reduction, Refinement) related to animal welfare and protection. [less ▲]

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See detailEtude de la composition chimique et de l’activité antioxydante des différents extraits de la Lavande dentée (Lavandula dentata)
Bettaieb Rebey, I.; Bourgou, S.; Saidani Tounsi, M. et al

in Journal of New Sciences Agri & Biotech (2017), 39(2), 2096-2105

In this study, Lavandula dentata organs (roots, stems and leaves) were investigated for their essential oils, total phenolics, flavonoids contents and antioxidant activities. Essential oil yields were 0 ... [more ▼]

In this study, Lavandula dentata organs (roots, stems and leaves) were investigated for their essential oils, total phenolics, flavonoids contents and antioxidant activities. Essential oil yields were 0.22% in roots, 0.68 % in stems and 0.89 % in flowers. Major components of the oils were β-ocimene, limonene and 1,8 cineol in roots, stems and leaves and flowers, respectively. In all organs, total phenolics content ranged from 42.57 to 16.17 mg gallic acid equivalents per gram of dry weight (mg GAE/g DW).The antioxidant activities of Lavandula dentata extracts obtained from the three organs were assessed using two tests (DPPH and reducing power). The root extract was strongly effective as DPPH radical scavenger and reducing agent. Thus, the identification of individual target polyphenolic compounds of roots was performed by RP-HPLC. The major phenolic compound detected in roots was rosmarinic acid. This activity was high enough for the plant to be a new and natural source of strongly antioxidant substances for use as natural additives in food and pharmaceutical industry. [less ▲]

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See detailMens sana in corpore sano
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2017), 60(2),

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See detailSpin waves on chains of YIG particles: dispersion relations, Faraday rotation, and power transmission
Pike, Nicholas ULiege; Stroud, David

in European Physical Journal B -- Condensed Matter (2017), 90

We calculate the dispersion relations for spin waves on a periodic chain of spherical or cylindrical Yttrium Iron Garnet (YIG) particles. We use the quasistatic approximation, appropriate when kd <<1 ... [more ▼]

We calculate the dispersion relations for spin waves on a periodic chain of spherical or cylindrical Yttrium Iron Garnet (YIG) particles. We use the quasistatic approximation, appropriate when kd <<1, where k is the wave number and d the interparticle spacing. In this regime, because of the magnetic dipole-dipole interaction between the localized magnetic excitations on neighboring particles, dispersive spin waves can propagate along the chain. The waves are analogous to plasmonic waves generated by electric dipole-dipole interactions between plasmons on neighboring metallic particles. The spin waves can be longitudinal (L), transverse (T ), or elliptically polarized. We find that a linearly polarized spin wave undergoes a Faraday rotation as it propagates along the chain. The amount of Faraday rotation can be tuned by varying the off-diagonal component of the permeability tensor. We also discuss the possibility of wireless power transmission along the chain using these coupled spin waves. [less ▲]

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See detailShort-Term Local Adaptation of Historical Common Bean (Phaseolus vulgaris L.) Varieties and Implications for In Situ Management of Bean Diversity
Klaedtke, Stephanie ULiege; Caproni, Leonardo; Klauck, Julia et al

in International Journal of Molecular Sciences (2017), 18

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local ... [more ▼]

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local adaptation plays for the management of common bean diversity in situ. To the purpose, four historical bean varieties and one modern control were multiplied on two organic farms for three growing seasons. The fifteen resulting populations, the initial ones and two populations of each variety obtained after the three years of multiplication, were then grown in a common garden. Twenty-two Simple Sequence Repeat (SSR) markers and 13 phenotypic traits were assessed. In total, 68.2% of tested markers were polymorphic and a total of 66 different alleles were identified. FST analysis showed that the genetic composition of two varieties multiplied in different environments changed. At the phenotypic level, differences were observed in flowering date and leaf length. Results indicate that three years of multiplication suffice for local adaptation to occur. The spatial dynamics of genetic and phenotypic bean diversity imply that the maintenance of diversity should be considered at the scale of the network, rather than individual farms and gardens. The microevolution of bean populations within networks of gardens and farms emerges as a research perspective. [less ▲]

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See detailRevisiting global fossil fuel and biofuel emissions of ethane
Tzompa-Sosa, Z. A.; Mahieu, Emmanuel ULiege; Franco, Bruno ULiege et al

in Journal of Geophysical Research. Atmospheres (2017), 122(4), 2493--2512

Recent measurements over the Northern Hemisphere indicate that the long-term decline in the atmospheric burden of ethane (C2H6) has ended and the abundance increased dramatically between 2010 and 2014 ... [more ▼]

Recent measurements over the Northern Hemisphere indicate that the long-term decline in the atmospheric burden of ethane (C2H6) has ended and the abundance increased dramatically between 2010 and 2014. The rise in C2H6 atmospheric abundances has been attributed to oil and natural gas extraction in North America. Existing global C2H6 emission inventories are based on outdated activity maps that do not account for current oil and natural gas exploitation regions. We present an updated global C2H6 emission inventory based on 2010 satellite-derived CH4 fluxes with adjusted C2H6 emissions over the U.S. from the National Emission Inventory (NEI 2011). We contrast our global 2010 C2H6 emission inventory with one developed for 2001. The C2H6 difference between global anthropogenic emissions is subtle (7.9 versus 7.2 Tg yr−1), but the spatial distribution of the emissions is distinct. In the 2010 C2H6 inventory, fossil fuel sources in the Northern Hemisphere represent half of global C2H6 emissions and 95% of global fossil fuel emissions. Over the U.S., unadjusted NEI 2011 C2H6 emissions produce mixing ratios that are 14–50% of those observed by aircraft observations (2008–2014). When the NEI 2011 C2H6 emission totals are scaled by a factor of 1.4, the Goddard Earth Observing System Chem model largely reproduces a regional suite of observations, with the exception of the central U.S., where it continues to underpredict observed mixing ratios in the lower troposphere. We estimate monthly mean contributions of fossil fuel C2H6 emissions to ozone and peroxyacetyl nitrate surface mixing ratios over North America of ~1% and ~8%, respectively. [less ▲]

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See detailInterplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis.
Leclercq, Sophie ULiege; Derouaux, Adeline ULiege; Olatunji, Samir ULiege et al

in Scientific Reports (2017), 7

Bacteria utilize specialized multi-protein machineries to synthesize the essential peptidoglycan (PG) cell wall during growth and division. The divisome controls septal PG synthesis and separation of ... [more ▼]

Bacteria utilize specialized multi-protein machineries to synthesize the essential peptidoglycan (PG) cell wall during growth and division. The divisome controls septal PG synthesis and separation of daughter cells. In E. coli, the lipid II transporter candidate FtsW is thought to work in concert with the PG synthases penicillin-binding proteins PBP3 and PBP1b. Yet, the exact molecular mechanisms of their function in complexes are largely unknown. We show that FtsW interacts with PBP1b and lipid II and that PBP1b, FtsW and PBP3 co-purify suggesting that they form a trimeric complex. We also show that the large loop between transmembrane helices 7 and 8 of FtsW is important for the interaction with PBP3. Moreover, we found that FtsW, but not the other flippase candidate MurJ, impairs lipid II polymerization and peptide cross-linking activities of PBP1b, and that PBP3 relieves these inhibitory effects. All together the results suggest that FtsW interacts with lipid II preventing its polymerization by PBP1b unless PBP3 is also present, indicating that PBP3 facilitates lipid II release and/or its transfer to PBP1b after transport across the cytoplasmic membrane. This tight regulatory mechanism is consistent with the cell's need to ensure appropriate use of the limited pool of lipid II. [less ▲]

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See detailCluster growth in driven granular gases
Noirhomme, Martial ULiege; Ludewig, François; Vandewalle, Nicolas ULiege et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2017)

We investigate numerically and theoretically the internal structures of a driven granular gas in cuboidal cell geometries. Clustering is reported and particles are classified as gaseous or clustered via a ... [more ▼]

We investigate numerically and theoretically the internal structures of a driven granular gas in cuboidal cell geometries. Clustering is reported and particles are classified as gaseous or clustered via a local packing fraction criterion based on a Voronoi tessellation. We observe that small clusters arise in the corners of the box, elucidating early reports of partial clustering. These aggregates have a condensation-like surface growth. When a critical size is reached, a structural transition occurs and all clusters merge together, leaving a hole in the center of the cell. This hole then becomes the new center of particle capture. Taking into account all structural modifications and defining a saturation packing fraction, we propose an empirical model for the cluster growth. [less ▲]

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See detailSeven temperate terrestrial planets around the nearby ultracool dwarf star
Gillon, Michaël ULiege; Triaud, Amaury; Demory, Brice-Olivier et al

in Nature (2017), 542

One focus of modern astronomy is to detect temperate terrestrial exoplanets well-suited for atmospheric characterisation. A milestone was recently achieved with the detection of three Earth-sized planets ... [more ▼]

One focus of modern astronomy is to detect temperate terrestrial exoplanets well-suited for atmospheric characterisation. A milestone was recently achieved with the detection of three Earth-sized planets transiting (i.e. passing in front of) a star just 8% the mass of the Sun 12 parsecs away. Indeed, the transiting configuration of these planets combined with the Jupiter-like size of their host star - named TRAPPIST-1 - makes possible indepth studies of their atmospheric properties with current and future astronomical facilities. Here we report the results of an intensive photometric monitoring campaign of that star from the ground and with the Spitzer Space Telescope. Our observations reveal that at least seven planets with sizes and masses similar to the Earth revolve around TRAPPIST-1. The six inner planets form a near-resonant chain such that their orbital periods (1.51, 2.42, 4.04, 6.06, 9.21, 12.35 days) are near ratios of small integers. This architecture suggests that the planets formed farther from the star and migrated inward. The seven planets have equilibrium temperatures low enough to make possible liquid water on their surfaces. [less ▲]

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See detailImplementation of the biogenic emission model MEGAN(v2.1) into the ECHAM6-HAMMOZ chemistry climate model
Henrot, Alexandra-Jane ULiege; Stanelle, T.; Schröder, S. et al

in Geoscientific Model Development [=GMD] (2017), 10

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See detailOne-pot, Pd/Cu-catalysed synthesis of alkynyl-substituted 3-ylidene-dihydrobenzo[d]isothiazole 1,1-dioxides
Etse, Koffi Senam ULiege

in Tetrahedron Letters (2017), 58(8), 789793

Enyne-substituted benzoisothiazole derivatives have been synthesised under one-pot, operationally simple conditions using 2-iodo-N-(trimethylsilylethynyl)benzenesulfonamides and terminal alkynes as ... [more ▼]

Enyne-substituted benzoisothiazole derivatives have been synthesised under one-pot, operationally simple conditions using 2-iodo-N-(trimethylsilylethynyl)benzenesulfonamides and terminal alkynes as starting materials and a palladium–copper-based catalytic system. The structure of these heterocycles has been demonstrated by NMR spectroscopy and confirmed by X-ray crystallographic analysis. A plausible reaction mechanism has been proposed. [less ▲]

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See detailEnergy Efficiency in the Romanian Residential Building Stock: A Literature Review
Muresan, Adina Ana; Attia, Shady ULiege

in Renewable and Sustainable Energy Reviews (2017), 74

The building sector in Romania is dominated by residential buildings that are old and have poor thermal performance. As member of the European Union, Romania has to reach the objectives imposed by the ... [more ▼]

The building sector in Romania is dominated by residential buildings that are old and have poor thermal performance. As member of the European Union, Romania has to reach the objectives imposed by the Directive 2009/28/EC and to fulfill the requirements of the Energy Performance of Buildings Directive (EPBD) by year 2020. To reach the 2020 objectives, the old buildings from the Romanian building stock should be rehabilitated and the new buildings should be designed according to the latest thermal performance characteristics. The following paper presents the literature review of building energy performance in Romania. The purpose of the literature review analysis is to provide an overview on current building energy efficiency in Romania. The paper also presents future perspectives on implementation of high performance buildings such as the Passive House (PH), nearly Zero Energy Buildings (nZEB) and Net Zero Energy Buildings (NZEB). The reviewed publications and case studies are classified under three categories: policy and regulations, technology and feasibility. Finally, the paper presents a holistic perspective on the Strength, Weakness, Opportunities and Threats (SWOTs) of energy efficiency in Romania's residential building sector. [less ▲]

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See detailConception of a near-infrared spectrometer for ground-based observations of massive stars
Kintziger, Christian ULiege; Desselle, Richard ULiege; Loicq, Jerôme ULiege et al

in Journal of Astronomical Telescopes, Instruments, and Systems (2017), 3(1), 015002

In our contribution, we outline the different steps in the design of a fiber-fed spectrographic instrument for stellar astrophysics. Starting from the derivation of theoretical relationships from the ... [more ▼]

In our contribution, we outline the different steps in the design of a fiber-fed spectrographic instrument for stellar astrophysics. Starting from the derivation of theoretical relationships from the scientific requirements and telescope characteristics, the entire optical design of the spectrograph is presented. Specific optical elements, such as a toroidal lens, are introduced to improve the instrument’s efficiency. Then the verification of predicted optical performances is investigated through optical analyses, such as resolution checking. [less ▲]

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See detailA Multiplatform Experiment to Unravel Meso- and Submesoscale Processes in an Intense Front (AlborEx)
Pascual, Ananda; Ruiz, Simon; Olita, Antonio et al

in Frontiers in Marine Science (2017)

The challenges associated with meso- and submesoscale variability (between 1 and 100 km) require high-resolution observations and integrated approaches. Here we describe a major oceanographic experiment ... [more ▼]

The challenges associated with meso- and submesoscale variability (between 1 and 100 km) require high-resolution observations and integrated approaches. Here we describe a major oceanographic experiment designed to capture the intense but transient vertical motions in an area characterized by strong fronts. Finescale processes were studied in the eastern Alboran Sea (Western Mediterranean) about 400 km east of the Strait of Gibraltar, a relatively sparsely sampled area. In-situ systems were coordinated with satellite data and numerical simulations to provide a full description of the physical and biogeochemical variability. Hydrographic data confirmed the presence of an intense salinity front formed by the confluence of Atlantic Waters, entering from Gibraltar, with the local Mediterranean waters. The drifters coherently followed the northeastern limb of an anticyclonic gyre. Near real time data from acoustic current meter data profiler showed consistent patterns with currents of up to 1 m/s in the southern part of the sampled domain. High-resolution glider data revealed submesoscale structures with tongues of chlorophyll-a and oxygen associated with the frontal zone. Numerical results show large vertical excursions of tracers that could explain the subducted tongues and filaments captured by ocean gliders. A unique aspect of AlborEx is the combination of high-resolution synoptic measurements of vessel-based measurements, autonomous sampling, remote sensing and modeling, enabling the evaluation of the underlying mechanisms responsible for the observed distributions and biogeochemical patchiness. The main findings point to the importance of fine-scale processes enhancing the vertical exchanges between the upper ocean and the ocean interior. [less ▲]

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See detailThe importance of pollen chemistry in evolutionary host shifts of bees
Vanderplanck, Maryse ULiege; Vereecken, Nicolas; Grumiau, Laurent et al

in Scientific Reports (2017)

Although bee-plant associations are generally maintained through speciation processes, host shifts have occurred during evolution. Understanding shifts between both phylogenetically and morphologically ... [more ▼]

Although bee-plant associations are generally maintained through speciation processes, host shifts have occurred during evolution. Understanding shifts between both phylogenetically and morphologically unrelated plants (i.e., host-saltation) is especially important since they could have been key processes in the origin and radiation of bees. Probably far from being a random process, such host-saltation might be driven by hidden constraints associated with plant traits. We selected two clades of oligolectic bees (i.e., Colletes succinctus group and Melitta leporina group) foraging on co-flowering but unrelated host-plants to test this hypothesis. We analyzed floral scent, floral color and chemical composition of pollen from host and non-host plants of these two clades. We did not find evidence for host-plant evolution in the Melitta leporina group driven by one of the assayed floral traits. On the contrary, hosts of the C. succinctus group display similar primary nutritive content of pollen (i.e., amino acids and sterols) but not similar floral scent or color, suggesting that shared pollen chemistry probably mediates saltation in this clade. Our study revealed that constraints shaping floral associations are diverse and clearly depend on species life-history traits, but evidence suggests that pollen chemistry may act as a major floral filter and guide evolutionary host-shifts. [less ▲]

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See detailEnergy harvesting from galloping of prisms: A wind tunnel experiment
Hémon, Pascal; Amandolèse, Xavier; Andrianne, Thomas ULiege

in Journal of Fluids & Structures (2017), 70

We study the energy harvesting from the galloping oscillations of rigid prisms flexibly mounted in a wind tunnel. A square section and a 2/3 rectangular section are tested and the inclination angle of the ... [more ▼]

We study the energy harvesting from the galloping oscillations of rigid prisms flexibly mounted in a wind tunnel. A square section and a 2/3 rectangular section are tested and the inclination angle of the prisms referred to the flow direction is optimally adapted. The energy harvester is based on magnets moving with the prism in the front of a coil-core at rest. Energy is dissipated in a load resistance for which an optimal value is found. Efficiency of the "prism wind turbine" is weak compared to usual wind turbine due to the physics of the galloping mechanism. However such systems remain interesting for their potential of adaptation to various situations. [less ▲]

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See detailMolecular Mechanisms Involved in Schwann Cell Plasticity
Boerboom, Angélique ULiege; Dion, Valérie ULiege; CHARIOT, Alain ULiege et al

in Frontiers in Molecular Neuroscience (2017)

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See detailCyclotheonellazoles A–C, Potent Protease Inhibitors from the Marine Sponge Theonella aff. swinhoei
Issac, Michal; Aknin, Maurice; Gauvin-Bialecki, Anne et al

in Journal of Natural Products (2017), 80

he extract of a sample of the sponge Theonella aff. swinhoei collected in Madagascar exhibited promising in vitro antiplasmodial activity. The antiplasmodial activity was ascribed in part to the known ... [more ▼]

he extract of a sample of the sponge Theonella aff. swinhoei collected in Madagascar exhibited promising in vitro antiplasmodial activity. The antiplasmodial activity was ascribed in part to the known metabolite swinholide A. Further investigation of the extract afforded three unusual cyclic peptides, cyclotheonellazoles A–C (1–3), which contain six nonproteinogenic amino acids out of the eight acid units that compose these natural products. Among these acids the most novel were 4-propenoyl-2-tyrosylthiazole and 3-amino-4-methyl-2-oxohexanoic acid. The structure of the compounds was elucidated by interpretation of the 1D and 2D NMR data, HRESIMS, and advanced Merfay’s techniques. The new compounds were found to be nanomolar inhibitors of chymotrypsin and sub-nanomolar inhibitors of elastase, but did not present antiplasmodial activity. [less ▲]

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See detailAssessment of natural radioactivity and associated radiation hazards in sand building material used in Douala Littoral Region of Cameroon, using gamma spectrometry
Guembou Shouop, Cébastien Joel ULiege; Ndontchueng Moyo, Maurice; Chene, Grégoire ULiege et al

in Environmental Earth Sciences (2017), 76(164),

Twenty-four sand samples were collected from different sand quarries from Douala Littoral Region (Wouri, Dibamba, Mungo and Docteur Anse rivers and Atlantic Sea) along the Guinea Golf. These samples were ... [more ▼]

Twenty-four sand samples were collected from different sand quarries from Douala Littoral Region (Wouri, Dibamba, Mungo and Docteur Anse rivers and Atlantic Sea) along the Guinea Golf. These samples were investigated using gamma-ray spectrometry system. Highest values of 226Ra, 232Th and 40K measured specific activities expressed in Bq Kg−1 units were, respectively, 146.7 (in Youpoue–Bamenda 2) 102.9 (in Village 1) and 928 (in Northern Akwa 6) while the lowest values were found to be, respectively, 11.8 (in Northern Akwa 6), 8.0 (in Bonaberi–Bonamikano 4) and 54.0 (Youpoue 3). The potential radiological hazards parameters were assessed by calculating successively radium equivalent activity (Raeq), outdoor absorbed gamma dose rate (Dout), annual effective dose rate, internal hazard (Hin) and external hazard (Hex) indices and alpha and gamma index from using those sand in the construction of dwellings and large buildings. Results obtained show that annual dose absorbed by inhabitants due to sand construction use in Douala is below 1.0 mSv year−1. Therefore, most of the types of sands studied and incorporated in constructions appear to be safe as building material. The outputs from this research will be useful to assess the radiation hazards of sand building material in humans and to initiate a sand database together with a radiological map of the area at stake. [less ▲]

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See detailDraft Genome of the Axenic Strain Phormidesmis priestleyi ULC007, a Cyanobacterium Isolated from Lake Bruehwiler (Larsemann Hills, Antarctica)
Lara, Yannick ULiege; Durieu, Benoit ULiege; Cornet, Luc ULiege et al

in Genome Announcements (2017)

Phormidesmis priestleyi ULC007 is an Antarctic freshwater cyanobacte- rium. Its draft genome is 5,684,389 bp long. It contains a total of 5,604 protein- encoding genes, of which 22.2% have no clear ... [more ▼]

Phormidesmis priestleyi ULC007 is an Antarctic freshwater cyanobacte- rium. Its draft genome is 5,684,389 bp long. It contains a total of 5,604 protein- encoding genes, of which 22.2% have no clear homologues in known genomes. To date, this draft genome is the first one ever determined for an axenic cyanobacterium from Antarctica. [less ▲]

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See detailModeling the thickness dependence of the magnetic phase transition temperature in thin FeRh film
Ostler, Thomas ULiege; Craig, Barton; Thomas, Thomson et al

in Physical Review. B : Condensed Matter (2017), 95

FeRh and its first-order phase transition can open new routes for magnetic hybrid materials and devices under the assumption that it can be exploited in ultra-thin-film structures. Motivated by ... [more ▼]

FeRh and its first-order phase transition can open new routes for magnetic hybrid materials and devices under the assumption that it can be exploited in ultra-thin-film structures. Motivated by experimental measurements showing an unexpected increase in the phase transition temperature with decreasing thickness of FeRh on top of MgO, we develop a computational model to investigate strain effects of FeRh in such magnetic structures. Our theoretical results show that the presence of theMgO interface results in a strain that changes the magnetic configuration which drives the anomalous behavior. [less ▲]

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See detailUV Visible Spectrophotometric Determination of the Quality of Antiretroviral Drugs Distributed in Kinshasa
Ntambwe Kamangu, Erick; Mbinze Kindenge, Jérémie ULiege; Mingu M., Arnold et al

in Open Acces Library Journal (2017)

Background: Antiretrovirals (ARVs) are the molecules used in the fight against infection by the Human Immunodeficiency Virus (HIV). Their main objective is to stop the virus from replicating and thus ... [more ▼]

Background: Antiretrovirals (ARVs) are the molecules used in the fight against infection by the Human Immunodeficiency Virus (HIV). Their main objective is to stop the virus from replicating and thus allow the immune system to recover. In 2001, the program to fight against HIV/AIDS United Nations (UNAIDS) and its partners has decided to strengthen the pharmaceutical channel and improve access to good quality care. Thus ARV quality control is recommended. Objective: The objective of this work was to monitor the quality of ARVs distributed in Kinshasa. Methodology: In this work, UV-visible spectrophotometry is used for the analysis of ARVs presented in simple form distributed in the city of Kinshasa. Results: The results of this work show that the stated and analyzed ARVs contain active ingredients; there is no placebo. Ten percent of these ARVs are non-compliant with regard to dosing of the active test. Conclusion: These results confirm the need to control these drugs to protect patients from adverse consequences related to their poor quality. [less ▲]

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See detailPerfectly matched layers for convex truncated domains with discontinuous Galerkin time domain simulations
Modave, Axel; Lambrechts, Jonathan; Geuzaine, Christophe ULiege

in Computers & Mathematics with Applications (2017), 73(4), 684-700

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See detailEffect of different tillage systems on aggregate structure and inner distribution of organic carbon
Gao, Lili ULiege; Beckers, Eléonore ULiege; Liang, Guopeng et al

in Geoderma (2017), 288

Tillage is a common agricultural practice affecting soil structure and biogeochemistry. Pore network geometries are crucial to oxygen concentration, gas diffusivity, water location and water movement ... [more ▼]

Tillage is a common agricultural practice affecting soil structure and biogeochemistry. Pore network geometries are crucial to oxygen concentration, gas diffusivity, water location and water movement. Soil aggregates, 4–6 mm in diameter and collected from silty loam in Belgium and sandy loam in China, were scanned using a micro-computed tomography scanner. Images with a pixel size of 6.9 μm were then processed with ImageJ software for pore network analysis. The treatments were no tillage (C-NT) and conventional tillage (C-CT) in China, and shallow tillage (G-ST) and conventional tillage (G-CT) in Belgium. The results showed that aggregates in conservational tillage (G-ST and C-NT) had numerous connected pores compared with conventional tillage (G-CT and C-CT). The Euler number (Ev) was significantly lower and visible total porosity and surface area (SA) were significantly higher in conservational tillage (G-ST and C-NT) than in conventional tillage (G-CT and C-CT) in both studied locations. The predominant size of pores was significantly higher in conservational tillage (G-ST and C-NT) than in conventional tillage (G-CT and C-CT) (> 150 μm vs 90–120 μm). Pore location within the aggregates also showed differences, with porosity being evenly distributed in the aggregates under conventional tillage (G-CT and C-CT). Under conservational tillage (G-ST and C-NT), the aggregates were heterogeneous, showing higher porosity at the center of the aggregates. There was a higher soil organic carbon (SOC) content in the external layer than in the internal layer in conservational tillage in Belgium (G-ST). In no tillage in China (C-NT), the SOC in the external and internal layers, however, showed similar results. Overall, conventional tillage (G-CT and C-CT) reduced the proportion of the largest pores within soil aggregates, whereas there was no significant relationship between pore morphologies and SOC content. Further investigation is required to measure the active and slow carbon pool distribution in the different layers and under different tillage practices. [less ▲]

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See detailThe desire of parenthood: intuitive co-parental behaviors and quality of couple relationship among Italian and Belgian same-sex and opposite-sex couples.
Miscioscia, Marina ULiege; Blavier, Adelaïde ULiege; Pagone, Paolo et al

in Frontiers in Psychology (2017), 8(110),

Studies that focused on family issues have allowed a great understanding of the aspectsrelated to its subsystems, such as parenting desire and its expectations, couples’satisfaction and quality of child’s ... [more ▼]

Studies that focused on family issues have allowed a great understanding of the aspectsrelated to its subsystems, such as parenting desire and its expectations, couples’satisfaction and quality of child’s outcomes. All these aspects are greatly interconnectedand contribute to the creation of specific family dynamics, such as the quality offamily interactions. The present study focuses on intuitive co-parental behaviors andthe quality of couple relationship observed during the decision process (intention anddesire) to be (or become) parents. Our first goal was to explore these aspects ina cross-national sample made of Italian and Belgian heterosexual, lesbian and gaycouples. We then aimed to evaluate if the degree of internalized homophobia affectsco-parental alliance. The quality of couple relationship and co-parental behaviors havebeen evaluated through the recruitment of a group of 115 stable heterosexual, gay andlesbian couples (230 individuals, 20–50 years of age) without children, who wanted tobecome parents. We used the Prenatal Lausanne Trilogue Play to evaluate the Co-parental Alliance; the couple’s satisfaction was assessed with the Dyadic AdjustmentScale and the Internalized Homophobia with the MISS-LG. In line with the existentliterature, the analysis did not find any difference between lesbian, gay and heterosexualcouples in terms of co-parental alliance. High levels of couple adjustment lead to betterparental performances among both Italian and Belgian couples. The results suggestalso that sexual stigma differs from one country to another, and it has an impact on thecapability of managing co-parenting. Clinical implications should be verified in furtherlongitudinal studies in order to observe the impact on the inter-generational transmissionof psychopathology. [less ▲]

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See detailMagnetocaloric Properties of Zinc-Nickel Ferrites Around Room Temperature
El Maalam, Khadija; Fkhar, lahcen; Mohammed, Hamedoun et al

in Journal of Superconductivity and Novel Magnetism (2017)

In this paper, structural, magnetic, and magnetocaloric properties of zinc-doped nickel ferrite, Zn1−xNixFe2O4 (x = 0.3 and 0.4) were investigated. The samples were prepared using solid-state reaction. X ... [more ▼]

In this paper, structural, magnetic, and magnetocaloric properties of zinc-doped nickel ferrite, Zn1−xNixFe2O4 (x = 0.3 and 0.4) were investigated. The samples were prepared using solid-state reaction. X-ray diffraction (XRD) and magnetization measurements were performed to study crystallographic structure and magnetic properties. For a magnetic field changing from 0 to 5 T, the corresponding isothermal entropy change was found to be near 1.4 J/kg K for both samples. The decreasing of Ni content from x = 0.4 to 0.3, enables to shift the Curie temperature of Zn1−xNixFe2O4 from 450 K toward (325 K). As main results, it was found that the relative cooling power (RCP) could be significantly enhanced by changing Ni concentration in Zn1−xNixFe2O4 (505 J/kg (for x = 0.3) and 670 J/kg (for x = 0.4)), which is considered as a recommended parameter for a wide temperature range in magnetic refrigeration application. Our finding should inspire and open new ways for the enhancement of the magnetocaloric effect in spinel ferrite-based materials. [less ▲]

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See detailUse of primary and secondary polyvinylamines for efficient gene transfection
Dréan, Mathilde; Debuigne, Antoine ULiege; Gonçalves, Christine et al

in Biomacromolecules (2017), 18(2), 440-441

Gene transfection with polymeric carrier remains a challenge, particularly high transfection levels combined with low toxicity are hard to achieve. We herein revisit polyvinylamines, an old and neglected ... [more ▼]

Gene transfection with polymeric carrier remains a challenge, particularly high transfection levels combined with low toxicity are hard to achieve. We herein revisit polyvinylamines, an old and neglected family of cationic polymers. They can be readily obtained by controlled hydrolysis of polyvinylamides prepared through (controlled) radical polymerization. A series of tailor-made and well-defined polyvinylamines bearing primary amino groups, and poly(N- methylvinylamine) bearing secondary amines, were evaluated for the transfection of cells with pDNA as a function of their molar mass, molar mass distribution and degree of deacetylation. Unexpected high transfection levels, in combination with low cytotoxicity were recorded for both series. Surprisingly, a great impact of the molar mass was observed for the primary amine polyvinylamine series, whereas the results were mostly independent on molar mass or dispersity for the polymer bearing secondary amine. It was further established that a certain percentage of acetamide groups increased the transfection level, while maintaining low cytotoxicity. These results highlight for the first time the real potential of polyvinylamines as gene carriers, and make these polymers very attractive for further development in gene therapy. [less ▲]

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See detailGuide du chercheur américaniste à Rome et au Vatican
Dauphin, Jean-Christophe ULiege

in Nuevo Mundo Nuevos Mundos (2017)

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See detailHow phosphorus limitation can control climate-active gas sources and sinks
Gypens, Nathalie; Borges, Alberto ULiege; Ghyoot, Caroline

in Journal of Marine Systems (2017), 170

Since the 1950's, anthropogenic activities have increased nutrient river loads to European coastal areas. Subsequent implementation of nutrient reduction policies have led to considerably reduction of ... [more ▼]

Since the 1950's, anthropogenic activities have increased nutrient river loads to European coastal areas. Subsequent implementation of nutrient reduction policies have led to considerably reduction of phosphorus (P) loads from the mid-1980's, while nitrogen (N) loads were maintained, inducing a P limitation of phytoplankton growth in many eutrophied coastal areas such as the Southern Bight f the North Sea (SBNS). When dissolved inorganic phosphorus (DIP) is limiting, most phytoplankton organisms are able to indirectly acquire P from dissolved organic P (DOP). We investigate the impact of DOP use on phytoplankton production and atmospheric fluxes of CO2 and dimethylsulfide (DMS) in the SBNS from 1951 to 2007 using an extended version of the RMIRO-BIOGAS model. This model includes a description of the ability of phytoplankton organisms to use DOP as a source of P. Results show that primary production can increase up to 30% due to DOP uptake under limiting DIP conditions. Consequently, simulated DMS emissions also increase proportionally while CO2 emissions to the atmosphere decrease, relative to the reference simulation without DOP uptake [less ▲]

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See detailStress indicator gene expression profiles, colony dynamics and tissue development of honey bees exposed to sub-lethal doses of imidacloprid in laboratory and field experiments
De Smet, Lina; Hatjina; Ioannidis, Pavlos et al

in PLOS One (2017), 10(137),

In this study, different context-dependent effects of imidacloprid exposure on the honey bee response were studied. Honey bees were exposed to different concentrations of imidacloprid during a time period ... [more ▼]

In this study, different context-dependent effects of imidacloprid exposure on the honey bee response were studied. Honey bees were exposed to different concentrations of imidacloprid during a time period of 40 days. Next to these variables, a laboratory-field comparison was conducted. The influence of the chronic exposure on gene expression levels was determined using an in-house developed microarray targeting different immunity-related and detoxification genes to determine stress-related gene expression changes. Increased levels of the detoxification genes encoding, CYP9Q3 and CYT P450, were detected in imidacloprid- exposed honey bees. The different context-dependent effects of imidacloprid exposure on honey bees were confirmed physiologically by decreased hypopharyngeal gland sizes. Honey bees exposed to imidacloprid in laboratory cages showed a general immunosuppression and no detoxification mechanisms were triggered significantly, while honey bees infield showed a resilient response with an immune stimulation at later time points. However, the treated colonies had a brood and population decline tendency after the first brood cycle in the field. In conclusion, this study highlighted the different context-dependent effects of imidacloprid exposure on the honey bee response. These findings warn for possible pitfalls concerning the generalization of results based on specific experiments with short exposure times. The increased levels of CYT P450 and CYP9Q3 combined with an immune response reaction can be used as markers for bees which are exposed to pesticides in the field. [less ▲]

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See detailThermoelectric properties of layered calcium cobaltite Ca3Co4O9 from hybrid functional first-principles calculations
Lemal, Sébastien ULiege; Varignon, Julien ULiege; Bilc, Daniel ULiege et al

in Physical Review B (2017), 95

Using a combination of first-principles calculations based on density functional theory and Boltzmann semiclassical transport theory, we compute and study the properties of pristine layered calcium ... [more ▼]

Using a combination of first-principles calculations based on density functional theory and Boltzmann semiclassical transport theory, we compute and study the properties of pristine layered calcium cobaltite Ca3Co4O9. We model the system with the B1WC hybrid functional. Two supercells of increasing size which approximate the incommensurate crystallographic structure of the compound are studied and we determine their structural, magnetic, and electronic properties. It is found that the B1WC hybrid functional is appropriate to reproduce the structural, electronic, and magnetic properties, which are then extensively discussed. From the electronic band structure, the Seebeck (S) and electrical resistivity (ρ) tensors are computed using Boltzmann transport theory within the constant relaxation-time approximation. The differences between the diagonal components are detailed and reveal a strong in-plane anisotropy of the properties. The qualitative behavior of the averaged in-plane properties, S // and ρ//, is consistent with the measurements reported in the literature. Our calculation clarifies and provides a broad picture of the evolution of the thermoelectric properties with both carrier density and temperature, and suggests that the change in S// and ρ// around 100 K is not necessarily related to the magnetic transitions occurring around 100 K. [less ▲]

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See detailThe Role of Super-Atom Molecular Orbitals in Doped Fullerenes in a Femtosecond Intense Laser Field
Xiong, Hui; Mignolet, Benoît ULiege; Fang, Li et al

in Scientific Reports (2017), 7

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See detailSputum biomarkers in IPF: Evidence for raised gene expression and protein level of IGFBP-2, IL-8 and MMP-7.
GUIOT, Julien ULiege; Henket, Monique; Corhay, Jean-Louis ULiege et al

in PLoS ONE (2017), 12(2), 0171344

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare lung disease of unknown origin leading rapidly to death. This paper addresses the issue of whether sputum induction is a suitable tool to study ... [more ▼]

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare lung disease of unknown origin leading rapidly to death. This paper addresses the issue of whether sputum induction is a suitable tool to study respiratory tract inflammation and potential biomarkers in IPF compared to COPD, a fibrosing airway wall disease. METHODS: In a cross-sectional analysis, 15 IPF patients, 32 COPD and 30 healthy subjects underwent sputum induction. Total sputum cell counts and the amount of TGF- beta, IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, IL-8, IL-13, MMP-7, MMP-9, YKL-40, TNF-alpha and KL-6 in sputum supernatant were analysed. We also profiled gene expression of cells in the induced sputum for TGF-beta, MMP-7, YKL-40, IGFBP-2, IL-6, IL-8 and TNF-alpha. RESULTS: IPF patients, like COPD, had increased sputum absolute number of neutrophils, eosinophils, macrophages and epithelial cells compared to HS. IPF sputum supernatants had increased concentrations of IGFBP-2, IL-8, TGF-beta, MMP-7, MMP-9 and KL-6 (p<0.05, p<0.0001, p<0.05, p<0.05, p<0.0001, p<0.05 respectively) when compared to healthy subjects where COPD had higher IL-6 and TNF-alpha levels than IPF (p<0.05 and p<0.05 respectively) and HS (p<0.0001 and p<0.001 respectively) and higher IL-8 and MMP-9 than HS (p<0.0001 and p<0.001 respectively). Conversely to IL-6 and TNF-alpha, MMP-7 was increased in IPF compared to COPD (p<0.05). The KL-6 and MMP-7 protein levels in sputum were inversely correlated with total lung capacity (TLC, % of predicted) in IPF patients (r = -0.73 and r = -0.53 respectively). Sputum gene expression analysis identified a significant increase for IGFBP-2, IL-6, IL-8 and MMP-7 in IPF compared to HS (p<0.05, p<0.01, p<0.05 and p<0.0001 respectively) and for IGFBP-2, YKL-40, IL-6, IL-8 and MMP-7 compared to COPD (p<0.01, p<0.01, p<0.05, p<0.01 and p<0.0001 respectively). Furthermore, gene expression of TGF-beta was increased in IPF compared to COPD (p<0.001) but not to HS. CONCLUSION: Our data show clear increase in expression and production of IGFBP-2, IL-8 and MMP-7 in sputum from patients with IPF that may contribute to the disease. [less ▲]

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See detailPerineuronal nets and vocal plasticity in songbirds: a proposed mechanism to explain the difference between closed-ended and open-ended learning
Cornez, Gilles ULiege; Madison, F.N.; Van der Linden, A. et al

in Developmental Neurobiology (2017)

Perineuronal nets (PNN) are aggregations of chondroitin sulfate proteoglycans surrounding the soma and proximal processes of neurons, mostly GABAergic interneurons expressing parvalbumin. They limit the ... [more ▼]

Perineuronal nets (PNN) are aggregations of chondroitin sulfate proteoglycans surrounding the soma and proximal processes of neurons, mostly GABAergic interneurons expressing parvalbumin. They limit the plasticity of their afferent synaptic connections. In zebra finches PNN develop in an experience-dependent manner in the song control nuclei HVC and RA (nucleus robustus arcopallialis) when young birds crystallize their song. Because songbird species that are open-ended learners tend to recapitulate each year the different phases of song learning until their song crystallizes at the beginning of the breeding season, we tested whether seasonal changes in PNN expression would be found in the song control nuclei of a seasonally breeding species such as the European starling. Only minimal changes in PNN densities and total number of cells surrounded by PNN were detected. However, comparison of the density of PNN and of PNN surrounding parvalbumin-positive cells revealed that these structures are far less numerous in starlings that show extensive adult vocal plasticity, including learning of new songs throughout the year, than in the closed-ended learner zebra finches. Canaries that also display some vocal plasticity across season but were never formally shown to learn new songs in adulthood were intermediate in this respect. Together these data suggest that establishment of PNN around parvalbumin-positive neurons in song control nuclei has diverged during evolution to control the different learning capacities observed in songbird species. This differential expression of PNN in different songbird species could represent a key cellular mechanism mediating species variation between closed-ended and open-ended learning strategies. [less ▲]

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See detailInteractive family dynamics and Non-Suicidal Self-Injury in psychiatric adolescent patients: a single case study
Gatta, Michela; Miscioscia, Marina ULiege; Sisti, Marta et al

in Frontiers in Psychology (2017), 8(46),

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See detailClinical Characteristics of Abutment Teeth with Gingival Discoloration
Ristic, Ljubisa; Dakovic, Dragana; Postic, Srdjan et al

in Journal of Prosthodontics : Official Journal of the American College of Prosthodontists (2017)

Purpose: The grey-bluish discoloration of gingiva (known as “amalgam tattoo”) does not appear only in the presence of amalgam restorations. It may also be seen in cases of teeth restored with cast dowels ... [more ▼]

Purpose: The grey-bluish discoloration of gingiva (known as “amalgam tattoo”) does not appear only in the presence of amalgam restorations. It may also be seen in cases of teeth restored with cast dowels and porcelain-fused-to-metal (PFM) restorations. The aim of this article was to determine the clinical characteristics of abutment teeth with gingival discoloration. Materials and Methods: This research was conducted on 25 patients referred for cast dowel and PFM restorations. These restorations were manufactured from Ni-Cr alloys. Ninety days after cementing the fixed prosthodontic restorations, the abutment teeth (n=61) were divided into a group with gingival discoloration (GD) (n=25) and without gingival discoloration (NGD) (n=36). The control group (CG) comprised the contralateral teeth (n = 61). Plaque index, gingival index, clinical attachment level, and probing depth were assessed before fabrication and also 90 days after cementation of the PFM restorations. Results: The gingival index, clinical attachment level, and probing depths of the abutment teeth that had GD were statistically higher before restoration, in comparison with the abutment teeth in theNGDand control groups.Ninety days after cementation, the abutment teeth with GD had significantly lower gingival indexes and probing depths, compared to the abutment teeth in the NGD group. Both abutment teeth groups (GD and NGD) had significantly higher values of clinical attachment levels when compared to the control group. Therewere no statistically significant differences in plaque index values between the study groups. Conclusions: The results of this study indicated that impairment of periodontal status of abutment teeth seemed to be related to the presence of gingival discolorations. Therefore, fabrication of fixed prosthodontic restorations requires careful planning and abutment teeth preparation to minimize the occurrence of gingival discolorations. Clinical relevance: With careful preparation of abutment teeth for cast dowels and crown restorations it may be possible to decrease the frequency of gingival discolorations adjacent to abutment teeth. [less ▲]

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See detailCrystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis.
El Ghachi, Meriem ULiege; Howe, Nicole; Auger, Rodolphe et al

in Cellular and Molecular Life Sciences : CMLS (2017)

Type 2 phosphatidic acid phosphatases (PAP2s) can be either soluble or integral membrane enzymes. In bacteria, integral membrane PAP2s play major roles in the metabolisms of glycerophospholipids ... [more ▼]

Type 2 phosphatidic acid phosphatases (PAP2s) can be either soluble or integral membrane enzymes. In bacteria, integral membrane PAP2s play major roles in the metabolisms of glycerophospholipids, undecaprenyl-phosphate (C55-P) lipid carrier and lipopolysaccharides. By in vivo functional experiments and biochemical characterization we show that the membrane PAP2 coded by the Bacillus subtilis yodM gene is the principal phosphatidylglycerol phosphate (PGP) phosphatase of B. subtilis. We also confirm that this enzyme, renamed bsPgpB, has a weaker activity on C55-PP. Moreover, we solved the crystal structure of bsPgpB at 2.25 A resolution, with tungstate (a phosphate analog) in the active site. The structure reveals two lipid chains in the active site vicinity, allowing for PGP substrate modeling and molecular dynamic simulation. Site-directed mutagenesis confirmed the residues important for substrate specificity, providing a basis for predicting the lipids preferentially dephosphorylated by membrane PAP2s. [less ▲]

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See detailVLT/SPHERE robust astrometry of the HR8799 planets at milliarcsecond-level accuracy. Orbital architecture analysis with PyAstrOFit
Wertz, Olivier; Absil, Olivier ULiege; Gómez González, Carlos ULiege et al

in Astronomy and Astrophysics (2017), 598

HR8799 is orbited by at least four giant planets, making it a prime target for the recently commissioned Spectro-Polarimetric High-contrast Exoplanet REsearch (VLT/SPHERE). As such, it was observed on ... [more ▼]

HR8799 is orbited by at least four giant planets, making it a prime target for the recently commissioned Spectro-Polarimetric High-contrast Exoplanet REsearch (VLT/SPHERE). As such, it was observed on five consecutive nights during the SPHERE science verification in December 2014. We aim to take full advantage of the SPHERE capabilities to derive accurate astrometric measurements based on H-band images acquired with the Infra-Red Dual-band Imaging and Spectroscopy (IRDIS) subsystem, and to explore the ultimate astrometric performance of SPHERE in this observing mode. We also aim to present a detailed analysis of the orbital parameters for the four planets. We report the astrometric positions for epoch 2014.93 with an accuracy down to 2.0 mas, mainly limited by the astrometric calibration of IRDIS. For each planet, we derive the posterior probability density functions for the six Keplerian elements and identify sets of highly probable orbits. For planet d, there is clear evidence for nonzero eccentricity ($e \simeq 0.35$), without completely excluding solutions with smaller eccentricities. The three other planets are consistent with circular orbits, although their probability distributions spread beyond $e = 0.2$, and show a peak at $e \simeq 0.1$ for planet e. The four planets have consistent inclinations of about $30\deg$ with respect to the sky plane, but the confidence intervals for the longitude of ascending node are disjoint for planets b and c, and we find tentative evidence for non-coplanarity between planets b and c at the $2 \sigma$ level. [less ▲]

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See detailNumerical study of Balearic meteotsunami generation and propagation under synthetic gravity wave forcing
Matjaž, Ličer; Mourre, Baptiste; Troupin, Charles ULiege et al

in Ocean Modelling (2017), 111

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See detailLe behaviorisme logique en question
Dony, Arthur ULiege

in Bulletin d'Analyse Phénoménologique (2017), XIII(1), 1-19

Dans une démarche inspirée des sciences de la nature, le behaviorisme logique se présente comme une théorie philosophique visant à rendre compte des états mentaux de façon « objective », en réduisant ceux ... [more ▼]

Dans une démarche inspirée des sciences de la nature, le behaviorisme logique se présente comme une théorie philosophique visant à rendre compte des états mentaux de façon « objective », en réduisant ceux-ci au comportement observable. Comme l’énonçait déjà Hempel, il s’agit de traduire tout énoncé psychologique en un énoncé où ne figurent plus que des concepts physiques de façon à faire l’économie de la dimension subjective de l’expérience, laquelle ne constituerait rien de plus qu’un simple rouage à vide, inessentiel à l’état mental lui-même. Dans cet article, je propose d’examiner les principaux arguments, désormais jugés classiques, avancés par Wittgenstein, Ryle et Dennett en faveur de cette théorie. Mon but est non seulement de mettre au jour les déficiences de l’argumentation et les présupposés problématiques qui la guident, mais plus fondamentalement de montrer en quoi cette doctrine, en dépit de la popularité qu’elle s’est acquise en philosophie contemporaine, s’avère à l’analyse inconsistante. [less ▲]

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See detailRisk Factors of Clinical and Subclinical Endometritis in Cattle: a Review.
Adnane, Mounir; Kaidi, Rachid; Hanzen, Christian ULiege et al

in TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES (2017), 41

The postpartum period is a critical period in the life of dairy cattle and management of the most important problems and diseases at an early stage represents the key to successful dairy herd management ... [more ▼]

The postpartum period is a critical period in the life of dairy cattle and management of the most important problems and diseases at an early stage represents the key to successful dairy herd management. Endometritis is one of the most important and dramatic diseases that disrupt the reproductive performance of cows and reduce the livestock profitability. Because endometritis is a multifactorial disease and is caused by nonspecific bacteria, determining all the factors that enhance its risk of occurrence is more important than treating the disease. This review considers the evidence regarding the risk factors for postpartum endometritis in dairy cattle in an attempt to explain the causality between each risk factor and both clinical and subclinical endometritis. The present article will discuss the importance of determining the risk factors of endometritis that must be considered for the treatment of cows. For example, antibiotics must be associated with improvement of the rations in the case of nutritional deficit and metabolic problems. Furthermore, these risk factors represent an alternative to treatment by including them in an adequate preventive strategy to master at least the most important risk factor to limit the prevalence and severity of endometritis. We conclude that some factors are specific for one form of endometritis and some others are common between clinical and subclinical endometritis, but all of them make the disease more severe and frequent. [less ▲]

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See detail“Don't pretend to be my friend!” When an informal brand communication style backfires on social media
Gretry, Anaïs ULiege; Horváth, Csilla; Belei, Nina et al

in Journal of Business Research (2017), 74

Social media are now essential platforms for marketing communications, and the volume of consumer-brand in- teractions on these platforms is exploding. Even so, it remains unclear how brands should ... [more ▼]

Social media are now essential platforms for marketing communications, and the volume of consumer-brand in- teractions on these platforms is exploding. Even so, it remains unclear how brands should communicate with consumers to foster relationships and, in particular, to gain their trust. A fundamental decision in this regard is the choice of a communication style, specifically, whether an informal or a formal style should be used in social media communications. In this paper, we investigate how adopting an informal (vs. formal) communication style affects brand trust and demonstrate that using an informal style can either have a positive or negative effect on brand trust, depending on whether consumers are familiar with the brand or not. We further show that these ef- fects occur because consumers expect brands to behave according to social norms, such that the use of an infor- mal style is perceived to be appropriate for familiar brands and inappropriate for unfamiliar ones. [less ▲]

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See detailSearching for Rapid Orbital Decay of WASP-18b
Wilkins, Ashlee N.; Delrez, Laetitia; Barker, Adrian J. et al

in Astrophysical Journal Letters (2017), 836

The WASP-18 system, with its massive and extremely close-in planet, WASP-18b (M [SUB] p [/SUB] = 10.3M [SUB] J [/SUB], a = 0.02 au, P = 22.6 hr), is one of the best-known exoplanet laboratories to ... [more ▼]

The WASP-18 system, with its massive and extremely close-in planet, WASP-18b (M [SUB] p [/SUB] = 10.3M [SUB] J [/SUB], a = 0.02 au, P = 22.6 hr), is one of the best-known exoplanet laboratories to directly measure Q‧, the modified tidal quality factor and proxy for efficiency of tidal dissipation, of the host star. Previous analysis predicted a rapid orbital decay of the planet toward its host star that should be measurable on the timescale of a few years, if the star is as dissipative as is inferred from the circularization of close-in solar-type binary stars. We have compiled published transit and secondary eclipse timing (as observed by WASP, TRAPPIST, and Spitzer) with more recent unpublished light curves (as observed by TRAPPIST and Hubble Space Telescope) with coverage spanning nine years. We find no signature of a rapid decay. We conclude that the absence of rapid orbital decay most likely derives from Q‧ being larger than was inferred from solar-type stars and find that Q‧ ≥ 1 × 10[SUP]6[/SUP], at 95% confidence; this supports previous work suggesting that F stars, with their convective cores and thin convective envelopes, are significantly less tidally dissipative than solar-type stars, with radiative cores and large convective envelopes. [less ▲]

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See detailStrong XUV irradiation of the Earth-sized exoplanets orbiting the ultracool dwarf TRAPPIST-1
Wheatley, Peter J.; Louden, Tom; Bourrier, Vincent et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We present an XMM-Newton X-ray observation of TRAPPIST-1, which is an ultracool dwarf star recently discovered to host three transiting and temperate Earth-sized planets. We find the star is a relatively ... [more ▼]

We present an XMM-Newton X-ray observation of TRAPPIST-1, which is an ultracool dwarf star recently discovered to host three transiting and temperate Earth-sized planets. We find the star is a relatively strong and variable coronal X-ray source with an X-ray luminosity similar to that of the quiet Sun, despite its much lower bolometric luminosity. We find L_x/L_bol=2-4x10^-4, with the total XUV emission in the range L_xuv/L_bol=6-9x10^-4. Using a simple energy-limited model we show that the relatively close-in Earth-sized planets, which span the classical habitable zone of the star, are subject to sufficient X-ray and EUV irradiation to significantly alter their primary and perhaps secondary atmospheres. Understanding whether this high-energy irradiation makes the planets more or less habitable is a complex question, but our measured fluxes will be an important input to the necessary models of atmospheric evolution. [less ▲]

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