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See detailFew remarks regarding some unnatural aquarium fish breeds and improper fish maintenance
Eşanu, Valentin O.; Gavriloaie, Claudiu; Oroian, Ian G. et al

in Aquaculture, Aquarium, Conservation & Legislation (2015), 8(2), 236-243

Ornamental fish were kept in captivity from ancient times. Gradually, the ornamental fish industry became a profitable enterprise. Color, size and shape are important traits when we describe a fish as a ... [more ▼]

Ornamental fish were kept in captivity from ancient times. Gradually, the ornamental fish industry became a profitable enterprise. Color, size and shape are important traits when we describe a fish as a phenotypically uniform line, strain or breed. Numerous varieties of aquarium fish have been artificially modified regarding their body shape or coloration. Several varieties of fish are being artificially colored by painting and tattooing to improve their marketability. All these practices cause many health problems for fish. Education of the customers is a very important thing, because artificially modified fish continue to exist because of demand. [less ▲]

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See detailMerging multi-camera data to reduce motion analysis instrumental errors using Kalman filters
Schwartz, Cédric ULg; Denoël, Vincent ULg; Forthomme, Bénédicte ULg et al

in Computer Methods in Biomechanics and Biomedical Engineering (2015), 18(9), 952-960

In motion capture systems, markers are often seen by multiple cameras. All cameras do not measure the position of the markers with the same reliability because of environmental factors such as the ... [more ▼]

In motion capture systems, markers are often seen by multiple cameras. All cameras do not measure the position of the markers with the same reliability because of environmental factors such as the position of the marker in the field of view or the light intensity received by the cameras. Kalman filters offer a general framework to take the reliability of the various cameras into account and consequently improve the estimation of the marker position. The proposed process can be applied to both passive and active systems. Several reliability models of the cameras are compared for the Codamotion active system, which is considered as a specific illustration. The proposed method significantly reduces the noise in the signal, especially at long range distances. Therefore, it improves the confidence of the positions at the limits of the field of view. [less ▲]

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See detailPharmacodynamics, Efficacy and Safety of Sodium-Glucose Co-Transporter Type 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Mellitus.
Scheen, André ULg

in Drugs (2015), 75(1), 33-59

Inhibitors of sodium-glucose co-transporter type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are already available in many countries ... [more ▼]

Inhibitors of sodium-glucose co-transporter type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are already available in many countries (dapagliflozin, canagliflozin, empagliflozin and ipragliflozin) and some others are in a late phase of development. The available SGLT2 inhibitors share similar pharmacokinetic characteristics, with a rapid oral absorption, a long elimination half-life allowing once-daily administration, an extensive hepatic metabolism mainly via glucuronidation to inactive metabolites, the absence of clinically relevant drug-drug interactions and a low renal elimination as parent drug. SGLT2 co-transporters are responsible for reabsorption of most (90 %) of the glucose filtered by the kidneys. The pharmacological inhibition of SGLT2 co-transporters reduces hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. The amount of glucose excreted in the urine depends on both the level of hyperglycaemia and the glomerular filtration rate. Results of numerous placebo-controlled randomised clinical trials of 12-104 weeks duration have shown significant reductions in glycated haemoglobin (HbA1c), resulting in a significant increase in the proportion of patients reaching HbA1c targets, and a significant lowering of fasting plasma glucose when SGLT2 inhibitors were administered as monotherapy or in addition to other glucose-lowering therapies including insulin in patients with T2DM. In head-to-head trials of up to 2 years, SGLT2 inhibitors exerted similar glucose-lowering activity to metformin, sulphonylureas or sitagliptin. The durability of the glucose-lowering effect of SGLT2 inhibitors appears to be better; however, this remains to be more extensively investigated. The risk of hypoglycaemia was much lower with SGLT2 inhibitors than with sulphonylureas and was similarly low as that reported with metformin, pioglitazone or sitagliptin. Increased renal glucose elimination also assists weight loss and could help to reduce blood pressure. Both effects were very consistent across the trials and they represent some advantages for SGLT2 inhibitors when compared with other oral glucose-lowering agents. The pharmacodynamic response to SGLT2 inhibitors declines with increasing severity of renal impairment, and prescribing information for each SGLT2 inhibitor should be consulted regarding dosage adjustments or restrictions in moderate to severe renal dysfunction. Caution is also recommended in the elderly population because of a higher risk of renal impairment, orthostatic hypotension and dehydration, even if the absence of hypoglycaemia represents an obvious advantage in this population. The overall effect of SGLT2 inhibitors on the risk of cardiovascular disease is unknown and will be evaluated in several ongoing prospective placebo-controlled trials with cardiovascular outcomes. The impact of SGLT2 inhibitors on renal function and their potential to influence the course of diabetic nephropathy also deserve more attention. SGLT2 inhibitors are generally well-tolerated. The most frequently reported adverse events are female genital mycotic infections, while urinary tract infections are less commonly observed and generally benign. In conclusion, with their unique mechanism of action that is independent of insulin secretion and action, SGLT2 inhibitors are a useful addition to the therapeutic options available for the management of T2DM at any stage in the natural history of the disease. Although SGLT2 inhibitors have already been extensively investigated, further studies should even better delineate the best place of these new glucose-lowering agents in the already rich armamentarium for the management of T2DM. [less ▲]

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Lecture notes on Mobility (2015)

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See detailSmall Angle X-ray Scattering Insights into the Architecture-Dependent Emulsifying Properties of Amphiphilic Copolymers in Supercritical Carbon Dioxide
Alaimo, David ULg; Hermida Merino, Daniel; Grignard, Bruno ULg et al

in Journal of Physical Chemistry B (2015), 119

The supramolecular assembly of a series of copolymers combining a PEO-rich hydrophilic and fluorinated CO2-philic sequences is analysed by synchrotron small-angle xray scattering (SAXS) in supercritical ... [more ▼]

The supramolecular assembly of a series of copolymers combining a PEO-rich hydrophilic and fluorinated CO2-philic sequences is analysed by synchrotron small-angle xray scattering (SAXS) in supercritical CO2, as well as in water/CO2 emulsions. These copolymers were designed to have the same molecular weight and composition, and to differ only by their macromolecular architecture. The investigated copolymers have random, block, and palm-tree architectures. Besides, thermo-responsive copolymer is also analysed, having a hydrophilic sequence becoming water-insoluble around 41 °C, i.e. just above the critical point of CO2. At the length scale investigated by SAXS, only the random copolymer appears to self-assemble in pure CO2, in the form of a disordered microgel-like network. The random, block and thermo-responsive copolymers are all able to stabilize water/CO2 emulsions but not the copolymer with the palm-tree architecture, pointing at the importance of macromolecular architecture for the emulsifying properties. A modelling of the SAXS data shows that the block and the thermo-responsive copolymers form spherical micelle-like structures containing about 70 % water and 30 % polymer. [less ▲]

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See detailTowards a New Edition of the 'Répertoire métrique de la poésie des troubadours'
Valenti, Gianluca ULg

in Neophilologus (2015), 99(1), 15-27

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See detailRetour au sport après plastie du ligament croisé antérieur : critères utilisés dans les cubs professionnels de football
Delvaux, François ULg; Rochcongar, P; Bruyère, Olivier ULg et al

in Science et Sports (2015), 30

Résumé Objectifs Analyser la démarche suivie par les médecins de clubs professionnels de football lorsqu’ils décident, en pratique quotidienne, d’autoriser le retour compétitif après plastie du ligament ... [more ▼]

Résumé Objectifs Analyser la démarche suivie par les médecins de clubs professionnels de football lorsqu’ils décident, en pratique quotidienne, d’autoriser le retour compétitif après plastie du ligament croisé antérieur chez un footballeur. Matériels et méthodes Trente-sept médecins responsables de clubs professionnels de football français et belges (Ligue 1, n = 15 ; Ligue 2, n = 14 ; Division 1 belge, n = 8) ont rempli un questionnaire à choix multiple concernant : (1) les critères utilisés afin de déterminer si un joueur est apte à reprendre la compétition après plastie du ligament croisé antérieur ; (2) l’importance relative de chacun de ces critères ; (3) le rôle éventuel d’intervenants spécifiques (kinésithérapeute…) dans cette décision. Résultats Plus de 80 % des médecins interrogés ont déclaré utiliser au moins huit critères (sur 17 proposés) afin d’évaluer la capacité d’un footballeur à reprendre la compétition après plastie du ligament croisé antérieur. Les trois critères considérés comme les plus déterminants étaient, par ordre d’importance : la stabilité dynamique du genou lors d’un exercice spécifique au football, la force musculaire et la récupération complète ou quasi complète d’amplitudes articulaires de flexion et d’extension de genou. Pour certains de ces critères (notamment la force musculaire), nous constatons cependant un manque de consensus sur les modalités pratiques d’évaluation, sur les paramètres ainsi que sur les valeurs-limites tolérées afin de garantir un retour sur terrain sécurisé. La prise en compte de l’avis du kinésithérapeute et du préparateur physique par une très nette majorité de médecins souligne l’importance d’un travail pluridisciplinaire. Conclusion L’utilisation de différents critères objectifs afin d’autoriser le retour compétitif après plastie du ligament croisé antérieur semble être une réalité dans le football professionnel. Des études supplémentaires devraient cependant contribuer à préciser les modalités des épreuves ainsi que des valeurs-seuils. ________________________________________ Summary Purpose To analyze how sport physicians decide, in their daily practice, when a professional soccer player with a reconstructed anterior cruciate ligament is able to get back to competitive activities. Materials and methods Thirty-seven physicians for professional French and Belgian soccer teams filled in a specific questionnaire dedicated to: (1) return-to-play criteria after anterior cruciate reconstruction; (2) the importance they assigned to each of these criteria in the return-to-play decision; (3) the potential role of professionals, such as physiotherapists or physical coaches in this decision. Results More than 80% of the respondents declared to use at least eight criteria in order to assess the player's ability to return to competitive soccer after anterior cruciate ligament reconstruction. The most important ones were (in order of importance): dynamic knee stability during a specific soccer exercise, muscle strength performance and normalization of knee flexion and extension ranges of motion. For most of these criteria (notably muscle strength), there was a lack of consensus about the choice of assessment parameters and the limit values allowing physicians to authorize or forbid the return-to-competition. A large majority of participants stated to take into consideration advices from physiotherapists or physical coaches for the return-to-play decision. Conclusion Sport physicians of professional soccer teams use relevant criteria to assess players’ ability to return to full sport after anterior cruciate ligament reconstruction. Further studies are required to determine the choice of assessment parameters and the limit values to assist physicians in return-to-play decisions. [less ▲]

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See detailL’innovation et ses territoires
Merenne-Schoumaker, Bernadette ULg

in Cahiers d'Economie et Gestion (2015), Mars-Mai

Analysis of innovation at three spatial scales: the world, countries and regional and local areas. Observation of the predominance of a center-periphery model

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See detailERRA-KIBRI, ŠABRA D’IDDIN-ILUM ET SES COLLEGUES
Colonna d'Istria, Laurent ULg; Beyer, Dominique

in Journal of Cuneiform Studies (2015), 67

In an article entitled “Wer war Tarâm-Mari?” K. Hecker (2008) published two private contracts from the Old Assyrian Karum II level at Kültepe-Kaniš (Kt m/k and Kt 102 m/171 k). These contracts bore the ... [more ▼]

In an article entitled “Wer war Tarâm-Mari?” K. Hecker (2008) published two private contracts from the Old Assyrian Karum II level at Kültepe-Kaniš (Kt m/k and Kt 102 m/171 k). These contracts bore the impression of the seal of someone who was a dependent of Iddin-Ilum, the ruler (šakkanakku) of the Syrian city of Mari. In this study we propose to read the name of the original owner of the seal as Erra-kibrī rather than as of Tarâm-Mari as had been previously proposed, and to identify him as a ŠABRA official. This seal also provides another example of representation of the goddess who wields a knife, one who occurs frequently on seals of ŠABRA’s and other officials during the reigns of Iddin-ilum and Isi-Dagan of Mari. [less ▲]

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See detailFamilial Isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene
Daly, Adrian ULg; Beckers, Albert ULg

in Endocrinology & Metabolism Clinics of North America (2015), 44

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See detailPaleomagnetic and geochemical record from cores from the Sea of Marmara, Turkey: Age constraints and implications of sapropelic deposition on early diagenesis
Drab, Laureen; Carlut, Julie; Hubert, Aurelia ULg et al

in Marine Geology (2015), 360

We present results of a multi-proxy analysis of two sediment cores from the Marmara Sea. The cores were ana- lyzed using paleomagnetic and geochemical measurements. Two sapropels are documented in the ... [more ▼]

We present results of a multi-proxy analysis of two sediment cores from the Marmara Sea. The cores were ana- lyzed using paleomagnetic and geochemical measurements. Two sapropels are documented in the last 11 kyr and are recorded in several locations across the Marmara Sea. These two sapropels have contrasting magnetic prop- erties. The magnetic record is affected by intense early diagenesis; the most recent upper sapropelic layer has low remanence and susceptibility values. A record of paleomagnetic inclinations could still be isolated above the dia- genesis front and is compared with secular variation models. The lower sapropel is identified in the deep part of the oldest studied core (Klg07) and has distinct magnetic properties characterized by high remanence and sus- ceptibility values. Using the magnetic properties it is possible to constrain bottom water ventilation and recon- nection episodes between the Marmara Sea and the Black Sea following the sea level rise during the last glacial to inter-glacial transition. [less ▲]

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (2015), 12

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See detailCompte rendu de 'Mutations et déterminisme chez Bourdieu'
Saint-Amand, Denis ULg

in Lectures (2015)

En définitive, il aurait sans doute mieux valu resserrer le propos sous la forme d’un article critique qui aurait pu trouver place dans une revue spécialisée : ne se donnant par les moyens de ses trop ... [more ▼]

En définitive, il aurait sans doute mieux valu resserrer le propos sous la forme d’un article critique qui aurait pu trouver place dans une revue spécialisée : ne se donnant par les moyens de ses trop hautes ambitions, l’ouvrage se révèle trop léger en plus de se distinguer par le manque de soin apporté à sa réalisation [less ▲]

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See detailHypothalamic Expression Of Oestrogen Receptor Alpha And Androgen Receptor Is Sex, Age And Region Dependent In Mice.
Brock, Olivier; Mees, Christelle De; Bakker, Julie ULg

in Journal of neuroendocrinology (2015)

Sex steroid hormones act on developing neural circuits regulating the hypothalamic-pituitary-gonadal axis and are involved in hormone-sensitive behaviours. These hormones act mainly via nuclear receptors ... [more ▼]

Sex steroid hormones act on developing neural circuits regulating the hypothalamic-pituitary-gonadal axis and are involved in hormone-sensitive behaviours. These hormones act mainly via nuclear receptors, i.e. oestrogen receptor-alpha (ERalpha) and androgen receptor (AR). By using immunohistochemistry, we analysed the expression level of ERalpha and AR throughout perinatal life [at embryonic (E) day 19 and postnatal (P) days 5-15-25] and in adulthood in several hypothalamic nuclei controlling reproduction in both wild-type (WT) and aromatase knockout (ArKO) (which cannot convert testosterone into oestradiol) mice to determine whether there are sex differences in hypothalamic ERalpha and AR expression and if so, whether these are established by oestradiol action. As early as E19, ERalpha immunoreactivity (-ir) was observed at same expression levels in both sexes in the anteroventral periventricular nucleus (AVPv), the medial preoptic area (MPOA), the bed nucleus of the stria terminalis (BnST), the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) and the arcuate nucleus (ARC). Sex differences (female > male) in ERalpha-ir were only observed during the prepubertal period in the BnST (P5 to P25) and the MPOA (P15), but also in adulthood in these two brain regions. Sex differences in AR-ir (male > female) were observed at P5 in the AVPv and ARC, and at P25 in the MPOA and ARC as well as in adulthood in all hypothalamic regions analysed. In adulthood, gonadectomy and hormonal treatment (oestradiol or dihydrotestosterone) also strongly modulated ERalpha-ir and AR, respectively. Taken together, sex differences in ERalpha-ir and AR-ir were observed in all hypothalamic regions analysed, but most likely do not reflect oestradiol actions since ArKO mice of both sexes showed very similar expression levels as WT mice throughout perinatal development. This article is protected by copyright. All rights reserved. [less ▲]

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See detailWelcome to papers from the Second International Meeting of Agora Paleobotanica
Cascales - Miñana, Borja ULg; Diez, José B.

in Historical Biology (2015), 27(3–4), 291293

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See detailL'infraction d'urbanisme qui affecte l'immeuble vendu donne-t-elle lieu à la garantie d'éviction ou à la garantie des vices cachés?
Onclin, François ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2015), (1), 24-34

Cette étude commente un arrêt de la Cour d'appel de Liège prononcé le 10 mai 2012. Quelles sont les voies d'action qui s'ouvrent à l'acheteur insatisfait qui découvre, après la vente, que le bien immeuble ... [more ▼]

Cette étude commente un arrêt de la Cour d'appel de Liège prononcé le 10 mai 2012. Quelles sont les voies d'action qui s'ouvrent à l'acheteur insatisfait qui découvre, après la vente, que le bien immeuble qu'il vient d'acquérir est en situation infractionnelle sur le plan du droit de l'urbanisme ? La question se pose de savoir si l'infraction d'urbanisme constitue une cause d'éviction ou un vice caché au sens du Code civil. [less ▲]

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See detailWithdrawal of Immunomodulators After Co-treatment Does Not Reduce Trough Level of Infliximab in Patients With Crohn's Disease.
Drobne, David; Bossuyt, Peter; Breynaert, Christine et al

in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (2015), 13(3), 514-5214

BACKGROUND & AIMS: The addition of immunomodulators increases the efficacy of maintenance therapy with infliximab for up to 1 year in patients with Crohn's disease who have not been previously treated ... [more ▼]

BACKGROUND & AIMS: The addition of immunomodulators increases the efficacy of maintenance therapy with infliximab for up to 1 year in patients with Crohn's disease who have not been previously treated with immunomodulators. However, there are questions about the effect of withdrawing immunomodulator therapy from these patients. We studied the effects of treatment with infliximab and immunomodulators (co-treatment) and then immunomodulator withdrawal on long-term outcomes of patients, as well as trough levels of infliximab and formation of anti-infliximab antibodies (ATI). METHODS: In a retrospective study with the median follow-up period of 34 months (interquartile range, 19-58 months), we analyzed data from 223 patients treated for Crohn's disease between May 1999 and December 2010 at the University Hospitals, Leuven, Belgium (65 received infliximab monotherapy, 158 received infliximab and an immunomodulator). Trough levels of infliximab and levels of ATI were measured in blood samples collected from 117 patients throughout co-treatment, as well as the time of immunomodulator withdrawal and after withdrawal. RESULTS: Patients receiving co-treatment had higher trough levels of infliximab (adjusted mean increase, 1.44-fold) than those receiving infliximab monotherapy (95% confidence interval [CI], 1.07-1.92; P = .02). A smaller percentage of patients receiving co-treatment developed ATI (35 of 158, 22%) than those receiving infliximab monotherapy (25 of 65, 38%; P = .01). Among co-treated patients, levels of infliximab remained stable after immunomodulators were withdrawn (before: 3.2 mug/mL; 95% CI, 1.6-5.8 mug/mL and after: 3.7 mug/mL; 95% CI, 1.3-6.3 mug/mL; P = .70). After withdrawal of immunomodulators, 45 of 117 patients (38%) required increasing doses of infliximab, and 21 of 117 (18%) discontinued infliximab. At the time of immunomodulator withdrawal, trough levels of infliximab and C-reactive protein were most strongly associated with response to infliximab thereafter. CONCLUSIONS: In a retrospective analysis, we confirmed that withdrawal of immunomodulators after at least 6 months (median, 13 months) of co-treatment with infliximab does not reduce the trough levels of infliximab in patients with Crohn's disease. Detectable trough levels of infliximab at the time of immunomodulator withdrawal are associated with long-term response. [less ▲]

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See detailA 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density: Results From the ADAMO Trial.
Langdahl, Bente L.; Teglbjaerg, Christence S.; Ho, Pei-Ran et al

in The Journal of clinical endocrinology and metabolism (2015), 100(4), 1335-1342

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men ... [more ▼]

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men with low BMD. Design: Phase 3 study with two treatment periods: a previously reported 12-month double-blind, placebo-controlled phase and a 12-month open-label phase. Setting: Multicenter in North America and Europe. Participants: 228 men entered the open-label phase and 219 completed the study. Intervention: Men from the original denosumab (long-term) and placebo (crossover) groups received denosumab 60 mg SC every 6 months. Main Outcome Measures: BMD, serum C-telopeptide (sCTX), and safety. Results: During the open-label phase, continued BMD increases occurred with long-term denosumab treatment (2.2% lumbar spine; 0.9% total hip; 1.3% femoral neck; 1.3% trochanter; and 0.2% 1/3 radius), resulting in cumulative 24-month gains from baseline of 8.0%, 3.4%, 3.4%, 4.6%, and 0.7%, respectively (all P<0.01). The crossover group showed BMD gains after 12 months of denosumab treatment similar to the long-term denosumab group during the first treatment year. Significant reductions in sCTX were observed following denosumab administration. Adverse events rates were similar between groups and no new safety signals identified. Conclusions: In men with low BMD, denosumab treatment for a second year continued to increase BMD, maintained reductions in bone resorption, and was well tolerated. BMD increased in men initiating denosumab during the second year. These effects were similar to those previously seen in postmenopausal women with osteoporosis and men with prostate cancer on androgen deprivation therapy. [less ▲]

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See detailComplex dynamics of a nonlinear aerospace structure: numerical continuation and normal modes
Renson, Ludovic ULg; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Nonlinear Dynamics (2015), 79(2), 1293-1309

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining ... [more ▼]

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining additional insight into the nonlinear dynamics that was observed experimentally, but also for uncovering additional nonlinear phenomena, such as quasiperiodic regimes of motion. Forced/unforced, damped/undamped numerical simulations are carried out using advanced techniques and theoretical concepts such as numerical continuation and nonlinear normal modes. [less ▲]

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See detailThe Cellobiose Sensor CebR is the Gatekeeper of Streptomyces scabies Pathogenicity
Francis, Isolde; Jourdan, Samuel ULg; Fanara, Steven ULg et al

in MBio (2015)

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See detailSartre in Venedig: der Mann, der in die Kälte ging
Cormann, Grégory ULg; Viehöver, Vera ULg

in Bulletin d'Analyse Phénoménologique (2015), 11

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See detailExtracellular peptidase hunting for improvement of protein production in plant cells and roots
Lallemand, Jérôme ULg; Bouché, Frédéric ULg; Desiron, Carole et al

in Frontiers in Plant Science (2015), 6(37),

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now ... [more ▼]

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now reaching the market, progress are still needed to improve plant hosts and strategies for biopharming. Targeting recombinant proteins toward the extracellular space offers several advantages in terms of protein folding and purification, but degradation events are observed, due to endogenous peptidases. This paper focuses on the analysis of extracellular proteolytic activities in two production systems: cell cultures and root-secretion (rhizosecretion), in Arabidopsis thaliana and Nicotiana tabacum. Proteolytic activities of extracellular proteomes (secretomes) were evaluated in vitro against two substrate proteins: bovine serum albumin (BSA) and human serum immunoglobulins G (hIgGs). Both targets were found to be degraded by the secretomes, BSA being more prone to proteolysis than hIgGs. The analysis of the proteolysis pH-dependence showed that target degradation was mainly dependent upon the production system: rhizosecretomes contained more peptidase activity than extracellular medium of cell suspensions, whereas variations due to plant species were smaller. Using class-specific peptidase inhibitors, serine and metallopeptidases were found to be responsible for degradation of both substrates. An in-depth in silico analysis of genomic and transcriptomic data from Arabidopsis was then performed and led to the identification of a limited number of serine and metallo-peptidases that are consistently expressed in both production systems. These peptidases should be prime candidates for further improvement of plant hosts by targeted silencing. [less ▲]

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See detailCaryl Phillips’s drama: Liminal fiction under construction?
Ledent, Bénédicte ULg

in Journal of Postcolonial Writing (2015), 51(1), 84-94

Most of the existing criticism on Caryl Phillips deals with his novels or his essays. His plays, which were for the most part written in the 1980s, have received comparatively little attention. This ... [more ▼]

Most of the existing criticism on Caryl Phillips deals with his novels or his essays. His plays, which were for the most part written in the 1980s, have received comparatively little attention. This article argues that Phillips’s dramatic production should be examined closely because it contains in a nutshell some of the themes and characters that recur in his more mature work and therefore form the backbone of his world vision. Such a comparative approach helps to highlight Phillips’s artistic consistency and his ability to give different forms to similar concerns. More specifically, its aim is to show to what extent Phillips’s novel In the Falling Snow (2009) is a liminal text that is in fact built upon the preoccupations at the heart of his early plays, most notably Strange Fruit (1981), Where There Is Darkness (1982) and The Shelter (1983). [less ▲]

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See detailCaractéristiques et performances de reproduction du Zebu. Le cas du Niger.
Moussa Garba, Mahamadou; Issa, M; Hanzen, Christian ULg

in Revue Africaine de Santé et de Productions Animales [=RASPA] (2014), 12(3-4), 135-141

This review presents an overview of the physiological and anatomical but also reproductive performance of African zebu characteristics. It is a first step to increase his milk and and meat potential by ... [more ▼]

This review presents an overview of the physiological and anatomical but also reproductive performance of African zebu characteristics. It is a first step to increase his milk and and meat potential by using more intensively artificial insemination (AI). The use of AI depends on the use of hormonal protocols to induce and synchronize oestrus. Actually, pregnancy rates obtained are between 31.4 and 46.6% respectively after use of PGF2a or progestagens. In Niger, the average pregnancy rates after artificial insemination is 29.9%. It is higher after in natural heat (43.4%) than induced heat (25.6%); It is also considerably lower after use of PGF2a (8.4%) than progestogens (23.4 to 39.5%). Improvement requires a better understanding of the effect of dietary factors, livestock or pathological responsible for fertility and fecundity. It is therefore important to continue and intensify field trials on more substantial numbers of animals. [less ▲]

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See detailLe délit de presse à l’ère numérique
Behrendt, Christian ULg

in Revue Belge de Droit Constitutionnel [= RBDC] (2014), 2014

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See detailMyzus persicae feeding on water stressed Arabidopsis affects the emission profile of plant volatile organic compounds
Truong, Dieu-Hien; Delaplace, Pierre ULg; Brostaux, Yves ULg et al

in Journal of Environment and Ecology (2014), 5(2),

Emissions of volatile organic compounds (VOCs) by water-controlled or water-stressed Arabidopsis thaliana infested or not infested with Myzus persicae were evaluated by headspace solid phase ... [more ▼]

Emissions of volatile organic compounds (VOCs) by water-controlled or water-stressed Arabidopsis thaliana infested or not infested with Myzus persicae were evaluated by headspace solid phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS). The infestations were maintained for 0–24 h, 24–48 h, and 48–72 h, and the emission profile for each time period was determined. Under these controlled conditions, the proportion of 4-methylpentyl isothiocyanate and dimethyl disulfide emitted by aphid-infested, water-stressed Arabidopsis was greater than that for aphid-infested water-controlled Arabidopsis over the 48–72 h sampling period. The proportion of terpene emitted by aphid-infested water-stressed plants also significantly increased compared with the other treatments over the three assayed sampling periods. In contrast, the proportion of 2-ethylhexanal (the only detected aldehyde) and ketones for the water-controlled plants generally remained high following aphid infestation. Taken together, these original data ascertain that abiotic factors can greatly interact to biotic stresses to alter the VOC emission profiles of plants. [less ▲]

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See detailCaractérisation de colluvions triasiques utilisés dans l'élaboration d'ustensiles rustiques de cuisson, cas de Talatast (Région de Marrakech, Maroc)
El Boudour El Idrissi, Hicham ULg; Daoudi, Lahcen; Collin, Frédéric ULg et al

in Verres, Céramiques & Composites (2014), 3(2), 18-22

The raw material used in the potter site of Talatast (Morocco) is collected from Triassic colluviums. Our study aims to characterize the mineralogical and geotechnical properties of the local clayey ... [more ▼]

The raw material used in the potter site of Talatast (Morocco) is collected from Triassic colluviums. Our study aims to characterize the mineralogical and geotechnical properties of the local clayey material before and after cooking. Our results confirm that the coarse particle size, the mineralogy of the clay fraction and the rate of fondants are suitable for the cookware material production. Defects encountered during the production are mainly related to the use of traditional ovens. Understanding the origin of the main defects could be helpful to promote the local pottery production. [less ▲]

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See detailMinimal anomaly-free chiral fermion sets and gauge coupling unification
Ceboa, Luis; Emmanuel-Costa, David; González Felipe, Ricardo et al

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2014)

We look for minimal chiral sets of fermions beyond the standard model that are anomaly free and, simultaneously, vectorlike particles with respect to color SU(3) and electromagnetic U(1). We then study ... [more ▼]

We look for minimal chiral sets of fermions beyond the standard model that are anomaly free and, simultaneously, vectorlike particles with respect to color SU(3) and electromagnetic U(1). We then study whether the addition of such particles to the standard model particle content allows for the unification of gauge couplings at a high energy scale, above 5.0 × 1015 GeV so as to be safely consistent with proton decay bounds. The possibility to have unification at the string scale is also considered. Inspired in grand unified theories, we also search for minimal chiral fermion sets that belong to SU(5) multiplets, restricted to representations up to imension 50. It is shown that, in various cases, it is possible to achieve gauge unification provided that some of the extra fermions decouple at relatively high intermediate scales. [less ▲]

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See detailBacterial Community Composition in Three Freshwater Reservoirs of Different Alkalinity and Trophic Status
Llirós, Marc; Inceoğlu, Özgul; García-Armisen, Tamara et al

in PLoS ONE (2014)

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See detailRapid dynamic activation of a marine-based Arctic ice cap
McMillan, M; Shepherd, A; Gourmelen, N et al

in Geophysical Research Letters (2014), 41(24), 89028909

We use satellite observations to document rapid acceleration and ice loss from a formerly slow-flowing, marine-based sector of Austfonna, the largest ice cap in the Eurasian Arctic. During the past two ... [more ▼]

We use satellite observations to document rapid acceleration and ice loss from a formerly slow-flowing, marine-based sector of Austfonna, the largest ice cap in the Eurasian Arctic. During the past two decades, the sector ice discharge has increased 45-fold, the velocity regime has switched from predominantly slow (~ 101 m/yr) to fast (~ 103 m/yr) flow, and rates of ice thinning have exceeded 25 m/yr. At the time of widespread dynamic activation, parts of the terminus may have been near floatation. Subsequently, the imbalance has propagated 50 km inland to within 8 km of the ice cap summit. Our observations demonstrate the ability of slow-flowing ice to mobilize and quickly transmit the dynamic imbalance inland; a process that we show has initiated rapid ice loss to the ocean and redistribution of ice mass to locations more susceptible to melt, yet which remains poorly understood. [less ▲]

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See detailDetection of response to command using voluntary control of breathing in disorders of consciousness
Charland-Verville, Vanessa ULg; Lesenfants, Damien; Sela, Lee et al

in Frontiers in Human Neuroscience (2014), 8(1020),

BACKGROUND: Detecting signs of consciousness in patients in a vegetative state/unresponsive wakefulness syndrome (UWS/VS) or minimally conscious state (MCS) is known to be very challenging. Plotkin et al ... [more ▼]

BACKGROUND: Detecting signs of consciousness in patients in a vegetative state/unresponsive wakefulness syndrome (UWS/VS) or minimally conscious state (MCS) is known to be very challenging. Plotkin et al. (2010) recently showed the possibility of using a breathing-controlled communication device in patients with locked in syndrome. We here aim to test a breathing-based "sniff controller" that could be used as an alternative diagnostic tool to evaluate response to command in severely brain damaged patients with chronic disorders of consciousness (DOC). METHODS: Twenty-five DOC patients were included. Patients' resting breathing-amplitude was measured during a 5 min resting condition. Next, they were instructed to end the presentation of a music sequence by sniffing vigorously. An automated detection of changes in breathing amplitude (i.e., >1.5 SD of resting) ended the music and hence provided positive feedback to the patient. RESULTS: None of the 11 UWS/VS patients showed a sniff-based response to command. One out of 14 patients with MCS was able to willfully modulate his breathing pattern to answer the command on 16/19 trials (accuracy 84%). Interestingly, this patient failed to show any other motor response to command. DISCUSSION: We here illustrate the possible interest of using breathing-dependent response to command in the detection of residual cognition in patients with DOC after severe brain injury. [less ▲]

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See detailEarly history of extended irreversible thermodynamics (1953-1983): an exploration beyond local equilibrium and classical transport theory
Lebon, Georgy ULg; Jou, david

in European Physical Journal H. Historical Perspectives on Contemporary Physics (2014), 5(23),

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See detailLa thermoplastie bronchique dans le traitement de l'asthme sévère de l'adulte.
Chanez, P.; Boulet, L.-P.; Brillet, P.-Y. et al

in Revue des maladies respiratoires (2014)

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since ... [more ▼]

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based treatment, the evaluation procedure of risks and benefits is different that for pharmaceutical products; safety aspects, regulatory requirements, study design and the assessment of the magnitude of effects may all be different. The mechanism of action and optimal patient selection need to be assessed further in rigorous clinical and scientific studies. This technique is in harmony with the development of personalised medicine in the 21st century. It should be developed further in response to the numerous challenges and needs not yet met in the management of severe asthma. [less ▲]

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See detailDrivers of inorganic carbon dynamics in first-year sea ice: A model study.
Moreau, Sebastien; Vancoppenolle, Martin; Delille, Bruno ULg et al

in Journal of Geophysical Research. Oceans (2014)

Sea ice is an active source or a sink for carbon dioxide (CO2), although to what extent is not clear. Here, we analyze CO2 dynamics within sea ice using a one-dimensional halo-thermodynamic sea ice model ... [more ▼]

Sea ice is an active source or a sink for carbon dioxide (CO2), although to what extent is not clear. Here, we analyze CO2 dynamics within sea ice using a one-dimensional halo-thermodynamic sea ice model including gas physics and carbon biogeochemistry. The ice-ocean fluxes and vertical transport of total dissolved inorganic carbon (DIC) and total alkalinity (TA) are represented using fluid transport equations. [less ▲]

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See detailEtude des facteurs influençant la visite des oiseaux dans les champs de riz
Nasasagare, Régine-Pacis; Ntakimazi, Gaspard; Libois, Roland ULg

in Bulletin scientifique de l'Institut national pour l'environnement et la conservation de la nature (2014), 13

This study was conducted in order to show pest bird species on rice in Burundi. An exhaustive ornithologic inventory was done in 45 fields in the plain of Rusizi and 30 in Ngozi fields were randomly ... [more ▼]

This study was conducted in order to show pest bird species on rice in Burundi. An exhaustive ornithologic inventory was done in 45 fields in the plain of Rusizi and 30 in Ngozi fields were randomly chosen and classified in 3 categories for Rusizi plain (2 for Ngozi): fully guarded plots, partially guarded plots and not guarded plots. There were no fields partially guarded for Ngozi. Resultats revealed a list of bird species that have a real impact on rice production in Burundi. The current study also allowed to put in evidence factors of the motivation of their visit. [less ▲]

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See detailMapping Gene Regulatory Networks in Drosophila Eye Development by Large-Scale Transcriptome Perturbations and Motif Inference
Potier, Delphine; Davie, Kristofer; Hulselmans, Gert et al

in Cell Reports (2014), 9(6), 2290-2303

Genome control is operated by transcription factors (TFs) controlling their target genes by binding to promoters and enhancers. Conceptually, the interactions between TFs, their binding sites, and their ... [more ▼]

Genome control is operated by transcription factors (TFs) controlling their target genes by binding to promoters and enhancers. Conceptually, the interactions between TFs, their binding sites, and their functional targets are represented by gene regulatory networks (GRNs). Deciphering in vivo GRNs underlying organ development in an unbiased genome-wide setting involves identifying both functional TF-gene interactions and physical TF-DNA interactions. To reverse engineer the GRNs of eye development in Drosophila, we performed RNA-seq across 72 genetic perturbations and sorted cell types and inferred a coexpression network. Next, we derived direct TF-DNA interactions using computational motif inference, ultimately connecting 241 TFs to 5,632 direct target genes through 24,926 enhancers. Using this network, we found network motifs, cis-regulatory codes, and regulators of eye development. We validate the predicted target regions of Grainyhead by ChIP-seq and identify this factor as a general cofactor in the eye network, being bound to thousands of nucleosome-free regions. [less ▲]

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See detailCyclovirus CyCV-VN species distribution is not limited to Vietnam and extends to Africa
Garigliany, Mutien-Marie ULg; Hagen, Ralf Mathias; Frickmann, Hagen et al

in Scientific Reports (2014), 4

Cycloviruses, small ssDNA viruses of the Circoviridae family, have been identified in the cerebrospinal fluid from symptomatic human patients. One of these species, cyclovirus-Vietnam (CyCV-VN), was shown ... [more ▼]

Cycloviruses, small ssDNA viruses of the Circoviridae family, have been identified in the cerebrospinal fluid from symptomatic human patients. One of these species, cyclovirus-Vietnam (CyCV-VN), was shown to be restricted to central and southern Vietnam. Here we report the detection of CyCV-VN species in stool samples from pigs and humans from Africa, far beyond their supposed limited geographic distribution. [less ▲]

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See detailEffets de deux associations culturales à base de blé sur les populations de pucerons (Homoptera: Aphididae) et d’auxiliaires aphidiphages: étude préliminaire menée en Chine
Chevalier Mendes Lopes, Thomas ULg; Bosquée, Emilie ULg; Honba, David et al

in Entomologie Faunistique = Faunistic Entomology (2014), 67

Crop associations have several advantages when plant species and crop production methods, including harvesting, are well selected. This preliminary study was conducted in the Shandong province (China) to ... [more ▼]

Crop associations have several advantages when plant species and crop production methods, including harvesting, are well selected. This preliminary study was conducted in the Shandong province (China) to better characterize the effect of wheat (Triticum aestivum L.)/oilseed rape (Brassica napus L.) and wheat/pea (Pisum sativum L.) associations on the aphid and aphidophagous beneficial populations. Aphids observed on wheat tillers were significantly more abundant in the pure stand of wheat during the two weeks prior to their population peak, compared with crop associations. Considering the aphidophagous beneficials, significantly more ladybirds were observed in the associations, compared with the pure stand during their abundance peak. Yellow pan traps were also used to assess the diversity and abundance of adult beneficial species. The parasitoid species Aphidius gifuensis (Ashmead) was prevalent. Among predators, Propylea japonica (Thunberg) and Harmonia axyridis (Pallas) were the most abundant species. This study contributes to better understand the potential of crop associations with wheat as a sustainable method to control aphid populations in this region of China. [less ▲]

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See detailLa mémoire du génocide des Juifs chez les jeunes. Connaissances, émotions et évaluations
Grandjean, Geoffrey ULg

in Questions de mémoire et de représentation (2014)

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See detailFirst Evidence of a Volatile Sex Pheromone in Lady Beetles
Fassotte, Bérénice ULg; Fischer, Christophe ULg; Durieux, Delphine ULg et al

in PLoS ONE (2014)

To date, volatile sex pheromones have not been identified in the Coccinellidae family; yet, various studies have suggested that such semiochemicals exist. Here, we collected volatile chemicals released by ... [more ▼]

To date, volatile sex pheromones have not been identified in the Coccinellidae family; yet, various studies have suggested that such semiochemicals exist. Here, we collected volatile chemicals released by virgin females of the multicolored Asian lady beetle, Harmonia axyridis (Pallas), which were either allowed or not allowed to feed on aphids. Virgin females in the presence of aphids, exhibited “calling behavior”, which is commonly associated with the emission of a sex pheromone in several Coleoptera species. These calling females were found to release a blend of volatile compounds that is involved in the remote attraction (i.e., from a distance) of males. Gas Chromatography-Mass Spectrometry (GC-MS) analyses revealed that (–)-β-caryophyllene was the major constituent of the volatile blend (ranging from 80 to 86%), with four other chemical components also being present; β-elemene, methyl-eugenol, α-humulene, and α-bulnesene. In a second set of experiments, the emission of the five constituents identified from the blend was quantified daily over a 9-day period after exposure to aphids. We found that the quantity of all five chemicals significantly increased across the experimental period. Finally, we evaluated the activity of a synthetic blend of these chemicals by performing bioassays which demonstrated the same attractive effect in males only. The results confirm that female H. axyridis produce a volatile sex pheromone. These findings have potential in the development of more specific and efficient biological pest-control management methods aimed at manipulating the behavior of this invasive lady beetle. [less ▲]

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See detailSound production in Onuxodon fowleri (Carapidae) and its amplification by the host shell
Kever, Loïc ULg; Colleye, Orphal ULg; Lugli, Marco et al

in Journal of Experimental Biology (2014), 217

Onuxodon species are well known for living inside pearl oysters. As in other carapids, their anatomy highlights their ability to make sounds but sound production has never been documented in Onuxodon ... [more ▼]

Onuxodon species are well known for living inside pearl oysters. As in other carapids, their anatomy highlights their ability to make sounds but sound production has never been documented in Onuxodon. This paper describes sound production in Onuxodon fowleri as well as the anatomy of the sound production apparatus. Single-pulsed sounds and multiple-pulsed sounds that sometimes last more than 3 s were recorded in the field and in captivity (Makemo Island, French Polynesia). These pulses are characterized by a broadband frequency spectrum from 100 to 1000 Hz. Onuxodon fowleri is mainly characterized by its ability to modulate the pulse period, meaning that this species can produce pulsed sounds and tonal-like sounds using the same mechanism. In addition, the sound can be remarkably amplified by the shell cavity (peak gain can exceed 10 dB for some frequencies). The sonic apparatus of O. fowleri is characterized by a rocker bone in front of the swimbladder, modified vertebrae and epineurals, and two pairs of sonic muscles, one of which (primary sonic muscle) inserts on the rocker bone. The latter structure, which is absent in other carapid genera, appears to be sexually dimorphic suggesting differences in sound production in males and females. Sound production in O. fowleri could be an example of adaptation where an animal exploits features of its environment to enhance communication. [less ▲]

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See detailHepatitis C Virus Life Cycle and Lipid Metabolism
Popescu, Costin-Ioan; Riva, Laura ULg; Vlaicu, Ovidiu et al

in Biology (2014), 3

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See detailDetection of small amounts of human adenoviruses in stools: comparison of a new immuno real-time PCR assay with classical tools.
Bonot, Sebastian; Ogorzaly, Leslie; Elmoualij, Benaïssa ULg et al

in Clinical Microbiology & Infection (2014), 20(12), 1-7

The detection of low virus concentrations in biological matrices, especially stool samples, is facing significant limitations as far as common diagnostic methods (enzyme-linked-immunosorbent assay (ELISA ... [more ▼]

The detection of low virus concentrations in biological matrices, especially stool samples, is facing significant limitations as far as common diagnostic methods (enzyme-linked-immunosorbent assay (ELISA) or quantitative real-time PCR (qPCR)) are considered. Here the development of a new immuno real-time PCR (iPCR) is described and its performance in the detection of human adenoviruses (HAdVs) in spiked stools is compared with those of ELISA and qPCR assays. For the iPCR, detection of the sandwich formed by the complexation of capture antibody-antigen-detection antibody was performed by qPCR thanks to the substitution of peroxydase by a chimeric DNA. This modification increased the detection sensitivity 200-fold compared to ELISA. The direct qPCR results revealed that only 0.3–9.5% of the spiked HAdV were detectable, resulting from important losses of DNA occurring at the extraction step. This step was not necessary in the iPCR workflow, avoiding this drawback. The losses of viral particles occurred at the elution step from the stool only. The recovery rate of the iPCR was thus better and ranged between 21 and 54%. As a result, iPCR enabled the detection of lower virus concentrations in stool samples compared to those detected by ELISA and qPCR. The iPCR could be considered as a ‘hyper sensitive ELISA’ for early detection of HAdV infections, especially in the case of immunocompromised patients after haematopoietic stem cell transplant. [less ▲]

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See detailMeasuring the Effect of Stochastic Perturbation Component in Cellular Automata Urban Growth Model
El Saeid Mustafa, Ahmed Mohamed ULg; Saadi, Ismaïl ULg; Cools, Mario ULg et al

in Procedia Environmental Sciences (2014), 22(Winter), 156168

Urban environments are complex dynamic systems whose prediction of the future states cannot exclusively rely on deterministic rules. Although several studies on urban growth were carried out using ... [more ▼]

Urban environments are complex dynamic systems whose prediction of the future states cannot exclusively rely on deterministic rules. Although several studies on urban growth were carried out using different modelling approaches, the measurement of uncertainties was commonly neglected in these studies. This paper investigates the effect of uncertainty in urban growth models by introducing a stochastic perturbation method. A cellular automaton is used to simulate predicted urban growth. The effect of stochastic perturbation is addressed by comparing series of urban growth simulations based on different degree of stochastic perturbation randomness with the original urban growth simulation, obtained with the sole cellular automata neighbouring effects. These simulations are evaluated using cell-to-cell location agreement and a number of spatial metrics. The model framework has been applied to the Ourthe river basin in Belgium. The results show that the accuracy of the model is increased by introducing a stochastic perturbation component with a limited degree of randomness, in the cellular automata urban growth model. [less ▲]

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See detailRGD surface functionalization of the hydrophilic acrylic intraocular lens material to control posterior capsular opacification
Huang, Yi-Shiang ULg; Bertrand, Virginie ULg; Bozukova, Dimitriya et al

in PLoS ONE (2014), 9(12), 32

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal ... [more ▼]

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient’s age or disease, surgical technique, and IOL design and material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative biomaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting material. In addition, compared to the hydrophobic IOL material, our bioactive biomaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this biomaterial has the potential to reduce the risk factor of PCO development. [less ▲]

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See detailAssessing spatio-temporal variability and trends in modelled and measured Greenland Ice Sheet albedo (2000–2013)
Alexander, P.; Tedesco, M.; Fettweis, Xavier ULg et al

in Cryosphere (The) (2014), 8

Accurate measurements and simulations of Greenland Ice Sheet (GrIS) surface albedo are essential, given the role of surface albedo in modulating the amount of absorbed solar radiation and meltwater ... [more ▼]

Accurate measurements and simulations of Greenland Ice Sheet (GrIS) surface albedo are essential, given the role of surface albedo in modulating the amount of absorbed solar radiation and meltwater production. In this study, we assess the spatio-temporal variability of GrIS albedo during June, July, and August (JJA) for the period 2000–2013. We use two remote sensing products derived from data collected by the Moderate Resolution Imaging Spectroradiometer (MODIS), as well as outputs from the Modèle Atmosphérique Régionale (MAR) regional climate model (RCM) and data from in situ automatic weather stations. Our results point to an overall consistency in spatio-temporal variability between remote sensing and RCM albedo, but reveal a difference in mean albedo of up to ~0.08 between the two remote sensing products north of 70° N. At low elevations, albedo values simulated by the RCM are positively biased with respect to remote sensing products by up to ~0.1 and exhibit low variability compared with observations. We infer that these differences are the result of a positive bias in simulated bare ice albedo. MODIS albedo, RCM outputs, and in situ observations consistently indicate a decrease in albedo of −0.03 to −0.06 per decade over the period 2003–2013 for the GrIS ablation area. Nevertheless, satellite products show a decline in JJA albedo of −0.03 to −0.04 per decade for regions within the accumulation area that is not confirmed by either the model or in situ observations. These findings appear to contradict a previous study that found an agreement between in situ and MODIS trends for individual months. The results indicate a need for further evaluation of high elevation albedo trends, a reconciliation of MODIS mean albedo at high latitudes, and the importance of accurately simulating bare ice albedo in RCMs. [less ▲]

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See detailReversible cross-linking of aliphatic polyamides bearing thermo- and photoresponsive cinnamoyl moieties
Tunc, Deniz ULg; Le Coz, Cédric; Alexandre, Michaël et al

in Macromolecules (2014), 47(23), 8247-8254

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See detailHigh plasma concentrations of sclerostin, an inhibitor of the Wnt signaling pathway in young horses affected by osteochondrosis
Serteyn, Didier ULg; Mendoza García, Luis ULg; Sandersen, Charlotte ULg et al

in Open journal of orthepedics (2014)

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and ... [more ▼]

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and healing process in older horses. Metabolic pathway analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation and cartilage repair such as Wnt/β-catenin, Indian hedgehog and TGF-β signaling pathways. Other regulated genes appeared to be involved in high carbohydrate diet, abnormal insulin metabolism or inflammation. Sclerostin is an osteocyte-secreted soluble antagonist of the Wnt/β-catenin signaling pathway. It is crucial for osteoblast development and activity and is increased in naturally occurring lesions of equine osteochondrosis. The aim of this study is to compare the circulating sclerostin levels between OC-affected (n = 20) and healthy horses (n = 19). A significant linear regression between plasma sclerostin and age is observed especially in the healthy young horses. The mean plasma sclerostin concentration is significantly higher in young horses suffering from osteochondrosis compared to the control horses. These results reinforce the possible role of the Wnt/β-catenin signaling pathway in the OC pathogeny. The inhibition of this essential pathway could disturb the osteo-chondral differentiation. More studies are currently needed to define the eventual clinic interest of plasma sclerostin as future biomarker in bone and cartilage diseases. [less ▲]

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See detailConstraining the Exozodiacal Luminosity Function of Main-sequence Stars: Complete Results from the Keck Nuller Mid-infrared Surveys
Mennesson, B.; Millan-Gabet, R.; Serabyn, E. et al

in Astrophysical Journal (2014), 797

Forty-seven nearby main-sequence stars were surveyed with the Keck Interferometer mid-infrared Nulling instrument (KIN) between 2008 and 2011, searching for faint resolved emission from exozodiacal dust ... [more ▼]

Forty-seven nearby main-sequence stars were surveyed with the Keck Interferometer mid-infrared Nulling instrument (KIN) between 2008 and 2011, searching for faint resolved emission from exozodiacal dust. Observations of a subset of the sample have already been reported, focusing essentially on stars with no previously known dust. Here we extend this previous analysis to the whole KIN sample, including 22 more stars with known near- and/or far-infrared excesses. In addition to an analysis similar to that of the first paper of this series, which was restricted to the 8-9 mum spectral region, we present measurements obtained in all 10 spectral channels covering the 8-13 mum instrumental bandwidth. Based on the 8-9 mum data alone, which provide the highest signal-to-noise measurements, only one star shows a large excess imputable to dust emission (eta Crv), while four more show a significant (>3sigma) excess: beta Leo, beta UMa, zeta Lep, and gamma Oph. Overall, excesses detected by KIN are more frequent around A-type stars than later spectral types. A statistical analysis of the measurements further indicates that stars with known far-infrared (lambda >= 70 mum) excesses have higher exozodiacal emission levels than stars with no previous indication of a cold outer disk. This statistical trend is observed regardless of spectral type and points to a dynamical connection between the inner (zodi-like) and outer (Kuiper-Belt-like) dust populations. The measured levels for such stars are clustering close to the KIN detection limit of a few hundred zodis and are indeed consistent with those expected from a populat [less ▲]

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See detailFlow Cytometry Assessment of CD34+ Viability in Thawed Cord Blood Units: A Multi-Center Eurocord and Netcord Study
SACCARDI, RICCARDO; AZQUETA, Carmen; BALLERINI, Lara et al

in Blood (2014), 124

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See detailInfluence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrils
Huynen, Céline ULg; Willet, Nicolas ULg; Duwez, Anne-Sophie ULg et al

in Biochimica et Biophysica Acta-Proteins and Proteomics (2014)

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See detailDirect route to well-defined poly(ionic liquid)s by controlled radical polymerization in water
Cordella, Daniela ULg; Kermagoret, Anthony ULg; Debuigne, Antoine ULg et al

in ACS Macro Letters (2014), 3

The precision synthesis of poly(ionic liquid)s (PILs) in water is achieved for the first time by the cobalt-mediated radical polymerization (CMRP) of N-vinyl-3-alkylimidazolium-type monomers following two ... [more ▼]

The precision synthesis of poly(ionic liquid)s (PILs) in water is achieved for the first time by the cobalt-mediated radical polymerization (CMRP) of N-vinyl-3-alkylimidazolium-type monomers following two distinct protocols. The first involves the CMRP of various 1-vinyl-3-alkylimidazolium bromides conducted in water in the presence of an alkyl–cobalt(III) complex acting as a monocomponent initiator and mediating agent. Excellent control over molar mass and dispersity is achieved at 30 °C. Polymerizations are complete in a few hours, and PIL chain-end fidelity is demonstrated up to high monomer conversions. The second route uses the commercially available bis(acetylacetonato)cobalt(II) (Co(acac)2) in conjunction with a simple hydroperoxide initiator (tert-butyl hydroperoxide) at 30, 40, and 50 °C in water, facilitating the scaling-up of the technology. Both routes prove robust and straightforward, opening new perspectives onto the tailored synthesis of PILs under mild experimental conditions in water. [less ▲]

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See detailEnrichment of Logging Gaps with a High Conservation Value Species (Pericopsis elata) in a Central African Moist Forest
Ouedraogo, Dakis-Yaoba ULg; Fayolle, Adeline ULg; Daïnou, Kasso ULg et al

in Forests (2014), 5(12), 3031-3047

In central Africa, most of the timber species require high light at the seedling stage for survival and growth. Forest managers face a regeneration shortage of these light-demanding timber species. To ... [more ▼]

In central Africa, most of the timber species require high light at the seedling stage for survival and growth. Forest managers face a regeneration shortage of these light-demanding timber species. To achieve long-term sustainability, there is a need for enrichment methods combining low cost and high species performance. The aim of this study was to assess the performance of Pericopsis elata seedlings in enriched logging gaps in Cameroon. Over five years; the survival and size of each seedling was monitored in 27 logging gaps that were either left without maintenance or cleared. Gaps were relatively small with an average total area of 155 m2. We found that planted seedlings of P. elata performed well in logging gaps. Even without any maintenance 61% of the planted seedlings survived after five years with an average annual diameter increment of 0.28 cm. P. elata appeared to be a good candidate species for enrichment in logging gaps. We demonstrated that the seedlings of P. elata tolerated a wide range of soil conditions but that their performance was strongly influenced by light availability (gap clearance), suggesting potentially improved performance of P. elata in high light environments such as in plantation or larger gaps. [less ▲]

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See detailNanocomposites based on MWCNT and polystyrene, styrene-acrylonitrile copolymer, or polymethylmethacrylate, obtained by miniemulsion polymerization
Donescu, Dan; Corobea, Mihai Cosmin; Petcu, Cristian et al

in Journal of Applied Polymer Science (2014), 131(23), 411481-10

Free radical miniemulsion polymerization of styrene (St), St/acrylonitrile 3 : 1 mixture or methylmethacrylate in the presence of multiwalled carbon nanotubes (MWCNT) was proven as a convenient way to ... [more ▼]

Free radical miniemulsion polymerization of styrene (St), St/acrylonitrile 3 : 1 mixture or methylmethacrylate in the presence of multiwalled carbon nanotubes (MWCNT) was proven as a convenient way to obtain homogenous hybrids with perspectives in associated applications like foams specialties materials. Miniemulsion polymerization was viable up to 2% wt. MWCNT to monomer, without agglomerations. The grafting on MWCNT during the polymerization occurs without the need for supplementary functionalization and the polymer grafted nanotubes showed stable dispersions in the polymer solvent. Monomer polarity affected the grafting ability during the polymerization process. The nanocomposites obtained after purification and drying were used in foaming process. MWCNT presence in the related nanocomposites decreased the pore sizes in foam-like materials (for all three different matrices). At 1 wt % MWCNT content, low density (< 0.3 g/cm3), low pore size (< 10 μm) and high cell density (>109 cell/cm3) were achieved. [less ▲]

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See detailFirst-line crizotinib versus chemotherapy in ALK-positive lung cancer.
Solomon, Benjamin J.; Mok, Tony; Kim, Dong-Wan et al

in The New England journal of medicine (2014), 371(23), 2167-77

BACKGROUND: The efficacy of the ALK inhibitor crizotinib as compared with standard chemotherapy as first-line treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC) is unknown. METHODS: We ... [more ▼]

BACKGROUND: The efficacy of the ALK inhibitor crizotinib as compared with standard chemotherapy as first-line treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC) is unknown. METHODS: We conducted an open-label, phase 3 trial comparing crizotinib with chemotherapy in 343 patients with advanced ALK-positive nonsquamous NSCLC who had received no previous systemic treatment for advanced disease. Patients were randomly assigned to receive oral crizotinib at a dose of 250 mg twice daily or to receive intravenous chemotherapy (pemetrexed, 500 mg per square meter of body-surface area, plus either cisplatin, 75 mg per square meter, or carboplatin, target area under the curve of 5 to 6 mg per milliliter per minute) every 3 weeks for up to six cycles. Crossover to crizotinib treatment after disease progression was permitted for patients receiving chemotherapy. The primary end point was progression-free survival as assessed by independent radiologic review. RESULTS: Progression-free survival was significantly longer with crizotinib than with chemotherapy (median, 10.9 months vs. 7.0 months; hazard ratio for progression or death with crizotinib, 0.45; 95% confidence interval [CI], 0.35 to 0.60; P<0.001). Objective response rates were 74% and 45%, respectively (P<0.001). Median overall survival was not reached in either group (hazard ratio for death with crizotinib, 0.82; 95% CI, 0.54 to 1.26; P=0.36); the probability of 1-year survival was 84% with crizotinib and 79% with chemotherapy. The most common adverse events with crizotinib were vision disorders, diarrhea, nausea, and edema, and the most common events with chemotherapy were nausea, fatigue, vomiting, and decreased appetite. As compared with chemotherapy, crizotinib was associated with greater reduction in lung cancer symptoms and greater improvement in quality of life. CONCLUSIONS: Crizotinib was superior to standard first-line pemetrexed-plus-platinum chemotherapy in patients with previously untreated advanced ALK-positive NSCLC. (Funded by Pfizer; PROFILE 1014 ClinicalTrials.gov number, NCT01154140.). [less ▲]

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See detailAlignment of quasar polarizations with large-scale structures
Hutsemekers, Damien ULg; Braibant, Lorraine ULg; Pelgrims, Vincent ULg et al

in Astronomy and Astrophysics (2014), 572

We have measured the optical linear polarization of quasars belonging to Gpc scale quasar groups at redshift z ~ 1.3. Out of 93 quasars observed, 19 are significantly polarized. We found that quasar ... [more ▼]

We have measured the optical linear polarization of quasars belonging to Gpc scale quasar groups at redshift z ~ 1.3. Out of 93 quasars observed, 19 are significantly polarized. We found that quasar polarization vectors are either parallel or perpendicular to the directions of the large-scale structures to which they belong. Statistical tests indicate that the probability that this effect can be attributed to randomly oriented polarization vectors is on the order of 1%. We also found that quasars with polarization perpendicular to the host structure preferentially have large emission line widths while objects with polarization parallel to the host structure preferentially have small emission line widths. Considering that quasar polarization is usually either parallel or perpendicular to the accretion disk axis depending on the inclination with respect to the line of sight, and that broader emission lines originate from quasars seen at higher inclinations, we conclude that quasar spin axes are likely parallel to their host large-scale structures. Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under program ID 092.A-0221.Table 1 is available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424631/olm">http://www.aanda.org</A> [less ▲]

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See detailShort-term spectroscopic variability of Plaskett's star
Palate, Matthieu ULg; Rauw, Grégor ULg

in Astronomy and Astrophysics (2014), 572

Context. Plaskett's star (HD 47129) is a very massive O-star binary in a post Roche-lobe overflow stage. CoRoT observations of this system revealed photometric variability with a number of frequencies ... [more ▼]

Context. Plaskett's star (HD 47129) is a very massive O-star binary in a post Roche-lobe overflow stage. CoRoT observations of this system revealed photometric variability with a number of frequencies. <BR /> Aims: The aim of this paper is to characterize the variations in spectroscopy and investigate their origin. <BR /> Methods: To sample its short-term variability, HD 47129 was intensively monitored during two spectroscopic campaigns of six nights each. The spectra were disentangled and Fourier analyses were performed to determine possible periodicities and to investigate the wavelength dependence of the phase constant and the amplitude of the periodicities. <BR /> Results: Complex line profile variations are observed. Frequencies near 1.65, 0.82, and 0.37 d[SUP]-1[/SUP] are detected consistently in the He i λ 4471, He ii λ 4542, and N iii λ 4510-4518 lines. These frequencies are consistent with those of the strongest signals detected in photometry. The possibilities that these variations stem from pulsations, a recently detected magnetic field or tidal interactions are discussed. <BR /> Conclusions: Whilst all three scenarios have their strengths, none of them can currently account for all the observed properties of the line profile variations. Based on observations collected at the Observatoire de Haute Provence (OHP, France). [less ▲]

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See detailWASP-94 A and B planets: hot-Jupiter cousins in a twin-star system
Neveu-VanMalle, M.; Queloz, D.; Anderson, D. R. et al

in Astronomy and Astrophysics (2014), 572

We report the discovery of two hot-Jupiter planets, each orbiting one of the stars of a wide binary system. <ASTROBJ>WASP-94A</ASTROBJ> (<ASTROBJ>2MASS 20550794-3408079</ASTROBJ>) is an F8 type star ... [more ▼]

We report the discovery of two hot-Jupiter planets, each orbiting one of the stars of a wide binary system. <ASTROBJ>WASP-94A</ASTROBJ> (<ASTROBJ>2MASS 20550794-3408079</ASTROBJ>) is an F8 type star hosting a transiting planet with a radius of 1.72 ± 0.06 R<SUB>Jup</SUB>, a mass of 0.452 ± 0.034 M<SUB>Jup</SUB>, and an orbital period of 3.95 days. The Rossiter-McLaughlin effect is clearly detected, and the measured projected spin-orbit angle indicates that the planet occupies a retrograde orbit. <ASTROBJ>WASP-94B</ASTROBJ> (<ASTROBJ>2MASS 20550915-3408078</ASTROBJ>) is an F9 stellar companion at an angular separation of 15'' (projected separation 2700 au), hosting a gas giant with a minimum mass of 0.618 ± 0.028 M<SUB>Jup</SUB> with a period of 2.008 days, detected by Doppler measurements. The orbital planes of the two planets are inclined relative to each other, indicating that at least one of them is inclined relative to the plane of the stellar binary. These hot Jupiters in a binary system bring new insights into the formation of close-in giant planets and the role of stellar multiplicity. The radial-velocity and photometric data used for this work are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/A49">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/A49</A> [less ▲]

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See detailThe use of microorganisms of cassava retting for the production of pectinolytic enzymes
Kouhounde, Sonagnon Hermann Serge ULg; Adeoti, Kifouli; Delvigne, Frank ULg et al

in Journal of Microbiology Biotechnology and Food Sciences (2014), 4(3), 277-281

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See detailMixed modes in red giants: a window on stellar evolution
Mosser, B.; Benomar, O.; Belkacem, K. et al

in Astronomy and Astrophysics (2014), 572

Context. The detection of oscillations with a mixed character in subgiants and red giants allows us to probe the physical conditions in their cores. <BR /> Aims: With these mixed modes, we aim at ... [more ▼]

Context. The detection of oscillations with a mixed character in subgiants and red giants allows us to probe the physical conditions in their cores. <BR /> Aims: With these mixed modes, we aim at determining seismic markers of stellar evolution. <BR /> Methods: Kepler asteroseismic data were selected to map various evolutionary stages and stellar masses. Seismic evolutionary tracks were then drawn with the combination of the frequency and period spacings. <BR /> Results: We measured the asymptotic period spacing for 1178 stars at various evolutionary stages. This allows us to monitor stellar evolution from the main sequence to the asymptotic giant branch and draw seismic evolutionary tracks. We present clear quantified asteroseismic definitions that characterize the change in the evolutionary stages, in particular the transition from the subgiant stage to the early red giant branch, and the end of the horizontal branch. <BR /> Conclusions: The seismic information is so precise that clear conclusions can be drawn independently of evolution models. The quantitative seismic information can now be used for stellar modeling, especially for studying the energy transport in the helium-burning core or for specifying the inner properties of stars entering the red or asymptotic giant branches. Modeling will also allow us to study stars that are identified to be in the helium-subflash stage, high-mass stars either arriving or quitting the secondary clump, or stars that could be in the blue-loop stage. Table 1 is only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/L5">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/L5</A> [less ▲]

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See detailVitrification, an efficient cryopreservation procedure but still rising some debates
Vanderzwalmen, Pierre; Ectors, Fabien ULg; Stecher, Astrid et al

in Current Trends in Clinical Embryology (2014), 1(1), 34-45

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See detailEvaluation of the oxidative stability of blends of ‘Arbequina’ olive oils with other monovarietal olive oils
Mansouri, F.; Ben Moumen, A.; Houmy, N. et al

in Olivae (Official Journal of the International Olive Council) (2014), 120

Like elsewhere in the Mediterranean, the olive oil sector is one of the strategic branches of the Moroccan economy owing to its social and economic significance. This research entailed evaluation of the ... [more ▼]

Like elsewhere in the Mediterranean, the olive oil sector is one of the strategic branches of the Moroccan economy owing to its social and economic significance. This research entailed evaluation of the oxidative stability of olive oils made up of a blend of ‘Arbequina’ olive oil with ‘Arbosana’ and ‘Koroneiki’ monovarietal oils known for their high content of natural antioxidants (phenols and tocopherols) and their superior oxidative stability compared with ‘Arbequina’ oil. The monovarietal oils produced from the ‘Arbequina’, ‘Arbosana’ and ‘Koroneiki’ varieties, which have recently been introduced under intensive cultivation in the eastern region of Morocco, underwent physico–chemical characterisation to determine quality criteria, natural antioxidant content, fatty acid composition and triacylglycerol profile. The Rancimat test* was performed to assess the oxidative stability of these monovarietal oils and their three-variety blends. The oxidation tests were performed on five freshly prepared blends (A) of the three varieties – ‘Arbequina’/’Arbosana’/‘Koroneiki’ – according to the following volume ratios: A1: 60/30/10; A2: 60/20/20; A3: 60:10:30; A4: 50:25:25 and A5: 40:30:30. The test results show that blends A4 and A5 displayed the best oxidative stability, recording respective values of 72.67 h and 75.42 h. These results are comparable to those obtained for ‘Arbosana’ monovarietal oil (75.42 h), which is considered to be relatively stable. Hence, blending is an excellent tool for enhancing oils produced from varieties which, despite their excellent initial quality and their organoleptic attributes, are handicapped by their poor stability, as is the case of ‘Arbequina’ oil. [less ▲]

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See detailDe Christophe Colomb à Barack Obama - une chronologie des musiques afro-américaines
Sacré, Robert ULg

in ABS Magazine (2014), (44), 15

Compte rendu d'un ouvrage de Jean Paul Levet , tome 1 ( sous titré Une chronologie des musiques afro-américaines)

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See detailA study of one-dimensional transport of Bose-Einstein condensates using exterior complex scaling
Dujardin, Julien ULg; Saenz, Alejandro; Schlagheck, Peter ULg

in Applied Physics B : Lasers & Optics (2014), 117(3), 765

We numerically investigate the one-dimensional transport of Bose-Einstein condensates in the context of guided atom lasers using a mean-field description of the condensate in terms of a spatially ... [more ▼]

We numerically investigate the one-dimensional transport of Bose-Einstein condensates in the context of guided atom lasers using a mean-field description of the condensate in terms of a spatially discretized Gross-Pitaevskii equation. We specifically consider a waveguide configuration in which spatial inhomogeneities and nonvanishing atom-atom interactions are restricted to a spatially localized scattering region of finite extent. We show how the method of smooth exterior complex scaling can be implemented for this particular onfiguration in order to efficiently absorb the outgoing flux within the waveguide. A numerical comparison with the introduction of a complex absorbing potential as well as with the analytically exact elimination of the dynamics of the free non-interacting motion outside the scattering region, giving rise to transparent boundary conditions, clearly confirms the accuracy and efficiency of the smooth exterior complex scaling method. [less ▲]

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See detailEvaluation of the durability of hydrophobic treatments on concrete architectural heritage
Lucquiaud, Vincent ULg; Courard, Luc ULg; Gérard, Olivier et al

in Restoration of Buildings and Monuments = Bauinstandsetzen und Baudenkmalpflege (2014), 20(6), 395404

The protection of historical concrete structures is a challenge for the coming years. Hydrophobic treatment may reduce the deterioration process while providing protection against water penetration ... [more ▼]

The protection of historical concrete structures is a challenge for the coming years. Hydrophobic treatment may reduce the deterioration process while providing protection against water penetration. Existing commercial products —mainly silane or siloxane in either water or solvent based formulations– were submitted to different ageing processes including UV radiation, dry-wet cycles, thermal shocks, freeze-thaw cycles, carbonation and their effectiveness has been evaluated on the basis of contact angle, vapour and chloride permeability and, capillarity water absorption. The results obtained clearly show that hydrophobic treatments display a good behaviour under the main ageing conditions. [less ▲]

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See detailMetacognitive components in learning to learn approaches
Frenkel, Stéphanie ULg

in International Journal of Psychology : A Biopsychosocial Approach (2014), 14

Background. Numerous students are having school difficulties linked to the way they learn. Some people speak of a “metacognitive deficit”. We refer to a “sleeping potential” instead. Be it psychologists ... [more ▼]

Background. Numerous students are having school difficulties linked to the way they learn. Some people speak of a “metacognitive deficit”. We refer to a “sleeping potential” instead. Be it psychologists, teachers or parents, all wish to develop their skills in order to help these students. This is the case in primary and secondary school. The EDUCA + project is intended to provide possible solutions. Purpose. The aim of this paper is to present a metacognitive and cognitive theory of learning to learn, which will (a) explain why numerous students are having school difficulties, and (b) predict the success of the EDUCA + project. [less ▲]

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See detailImpact of gender difference in hospital outcomes following percutaneous coronary intervention. Results of the Belgian Working Group on Interventional Cardiology (BWGIC) registry
LEMPEREUR, Mathieu ULg; Magne, Julien; Cornelis, Kristoff et al

in EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2014)

Aims: To determine whether there are gender-based differences in in-hospital outcomes among patients undergoing percutaneous coronary intervention (PCI). Methods and results: We studied a large cohort ... [more ▼]

Aims: To determine whether there are gender-based differences in in-hospital outcomes among patients undergoing percutaneous coronary intervention (PCI). Methods and results: We studied a large cohort using clinical data from a registry of 130,985 PCI procedures in Belgium, from January 2006 to February 2011. Compared to males, females were significantly older (70.3 vs. 64.8 years), and were more frequently diabetic or hypertensive. Men smoked more and more frequently had previous myocardial infarction (MI), previous PCI or previous coronary artery bypass graft (CABG) surgery. Coronary artery disease (CAD) was less severe in women, and PCI to the left anterior descending artery was more common in female patients. Unadjusted in-hospital mortality rates were higher in females versus males (2.5% for women and 1.6% for men, p<0.0001). After multivariable analysis, female gender remained an independent predictor of mortality (odds ratio 1.35, 95% CI: 1.22-1.49, p<0.0001). Conclusions: Gender-based differences in hospital mortality rates after PCI were observed in this large registry. Female sex remained an independent predictor of mortality after multivariable adjustment. [less ▲]

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See detailcompte rendu de : Luca MARTORELLI, Ps. Aurelii Augustini regulae
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (2014), 73(4), 1130-1132

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See detailUn blog plutôt qu’un Word ? Retour d’expérience de l’insertion d’un cours en ligne dans un programme de formation d’enseignants du supérieur.
Jérôme, Françoise ULg; Verpoorten, Dominique ULg

in Education & Formation (2014), e-302

En 2012-2013, le CAPAES (Certificat d’Aptitude Pédagogique Approprié à l’Enseignement Supérieur) de l’Université de Liège a incorporé pour la première fois à son programme un cours entièrement en ligne ... [more ▼]

En 2012-2013, le CAPAES (Certificat d’Aptitude Pédagogique Approprié à l’Enseignement Supérieur) de l’Université de Liège a incorporé pour la première fois à son programme un cours entièrement en ligne. L’article en expose les motivations sous-jacentes, présente les outils utilisés et analyse la réception du dispositif par les étudiants. Les données récoltées font apparaitre : a) la familiarité antérieure restreinte des enseignants avec les deux outils exploités dans le cours (une plate-forme eLearning traditionnelle et un blog comme représentant du Web 2.0), b) la capacité, en dépit de cette familiarité limitée, de faire bon usage des deux outils en tant qu’apprenant, c) une satisfaction générale pour le cours en ligne mais faiblement liée à la découverte des deux outils et à la prise de conscience, en tant qu’enseignant, de leur potentiel pédagogique. (L'article fournit en annexe le questionnaire complet utilisé pour recueillir le feed-back des enseignants ayant terminé le cours en ligne). [less ▲]

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See detailEmpirical modelling of the bifurcation behaviour of a bridge deck undergoing across-wind galloping
Andrianne, Thomas ULg; Dimitriadis, Grigorios ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2014), 135

This work presents an empirical model capable to describe the galloping bifurcation behaviour of a bridge deck. It is based on a general polynomial form proposed by Novak, which we limit to the 5th order ... [more ▼]

This work presents an empirical model capable to describe the galloping bifurcation behaviour of a bridge deck. It is based on a general polynomial form proposed by Novak, which we limit to the 5th order. The advantage of choosing this function for modelling the vertical force coefficient is that asymmetry of the even terms is enforced in order to reproduce the sub-critical aeroelastic behaviour of the bridge deck. The coefficients of the polynomial are identified from several pairs of displacement amplitudes and the corresponding airspeeds, measured in a wind tunnel during dynamic tests on the sectional bridge model. The identification is carried out using a first order harmonic balance technique. A stability analysis is presented in order to highlight the need of such a model to catch the complete bifurcation behaviour of the system. The resulting force coefficient of this full order model is compared to the well known models of Parkinson and Novak. Finally, the concept universal curve is used in order to discuss the galloping responses of square and rectangular cylinders, in comparison with the one of the bridge deck. [less ▲]

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See detailDe la satisfaction à la performance : Dépasser les indicateurs de satisfaction pour évaluer et réguler efficacement
Jacquet, Maud ULg; Maillart, Christelle ULg; Georges, François ULg et al

in Education & Formation (2014), e-302

Dans le cadre de la formation en logopédie à l'ULg, un examen certificatif de langue française a été mis en place afin de répondre aux exigences de la profession. Pour y préparer les étudiants, l’unité de ... [more ▼]

Dans le cadre de la formation en logopédie à l'ULg, un examen certificatif de langue française a été mis en place afin de répondre aux exigences de la profession. Pour y préparer les étudiants, l’unité de logopédie clinique, l’Institut Supérieur des Langues Vivantes (ISLV) et le Laboratoire de Soutien aux synergies Enseignement-Technologie (LabSET) de l’Université de Liège (ULg) ont conçu un dispositif hybride d’apprentissage et de remédiation en langue française. Depuis 2011, ce dispositif offre aux étudiants un environnement de travail en ligne visant à soutenir leur apprentissage autonome du français. Malgré une importante satisfaction vis-à-vis du dispositif, les performances demeurent insuffisantes. Cependant, un groupe d’étudiants se distinguent. Une analyse qualitative basée sur des interviews met en évidence chez ces étudiants 1) une bonne connaissance des stratégies cognitives efficaces en termes d’apprentissage, 2) une certaine capacité à planifier et ajuster leur travail et 3) des indicateurs d’une motivation autodéterminée et intrinsèque. Soutenus par le dispositif et ses caractéristiques, il est probable que ces facteurs soient à l’origine de leur succès. Pour des étudiants peut-être encore trop scolaires, principalement soucieux de leurs résultats à l'examen et peu enclins à identifier leurs besoins, la liberté offerte par le dispositif fait naitre un sentiment de satisfaction mais ne suffit pas à un apprentissage de qualité. [less ▲]

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See detailGouvernementalité, subjectivité et vérité
Thirion, Nicolas ULg

in Acta Fabula : Revue des Parutions en Théorie Littéraire (2014), 15(10),

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See detailMafia Practices and Italian Entrepreneurial Activities in the Belgian Food Sector. Research Objectives
De Biase, Marco ULg

in The European Review of Organised Crime (2014), 1(2), 81-96

This research aims to study the social and economic processes which encourage the spread of mafia practices among some Italian entrepreneurs in the Belgian food sector. My working hypothesis is that mafia ... [more ▼]

This research aims to study the social and economic processes which encourage the spread of mafia practices among some Italian entrepreneurs in the Belgian food sector. My working hypothesis is that mafia practices are violent and predatory strategies to monopolize the economic market, which rely on the use of heterogeneous and cross-class social networks. In this view, these activities of old and new Italian entrepreneurs in Belgium are not the result of the exportation of mafia methods through migratory or cultural ties, but rather the outcome of a complex economic system of production in which certain Italian entrepreneurs have established profitable enterprises in the legal market using violent modalities of accumulation and specific strategies of relation. This research is developed through an ethnographic approach grounded on biographical collection and on participant observation, which is carried out through direct involvement in commercial activities in the sectors of interest. [less ▲]

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See detailExperimental validation of a thermal model of a LOx flooded ball bearing
Servais, Christophe ULg; Bozet, Jean-Luc ULg; Kreit, Patrick ULg et al

in Tribology International (2014), 80

Ball bearings of turbopumps of rocket engines work in very singular conditions; they are flooded into liquid oxygen or liquid hydrogen. Therefore, the use of any conventional lubricants (oil or grease) is ... [more ▼]

Ball bearings of turbopumps of rocket engines work in very singular conditions; they are flooded into liquid oxygen or liquid hydrogen. Therefore, the use of any conventional lubricants (oil or grease) is prescribed. Although cryogenic fluids can cool this kind of ball bearing, they cannot separate the surfaces in contact. As a result, there is a significant increase in frictional power losses. This paper presents tests performed on a cryotechnic ball bearing flooded in liquid oxygen. The test results showed that beyond a critical loading of the bearing, a sudden increase in temperature occurred. A thermal model is also put forward, in order to understand and anticipate especially the thermal instability described above. [less ▲]

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See detailLa camorra e la periferia nel bosco
De Biase, Marco ULg

in Lavoro Culturale (2014)

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See detailLes solutions humaines. Victor Serge dans le XXe siècle
Cavazzini, Andrea ULg

in Cahiers du GRM (2014)

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See detailCracs, Neets... and Agency, le vocabulaire d’un autre monde... ou pas?
Vandoorne, Chantal ULg

in Education Santé (2014), (306), 7-8

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See detailLaTeX, un peu, beaucoup (6. Tableaux)
Dupont, Pascal ULg

in Losanges (2014), 27

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See detailSpecialist nurse in Europe: education, regulation and role
Dury, Cécile ULg

in International Nursing Review (2014), 61(4), 454-462

Background: The concept of a ‘specialist nurse’ has existed for many years and related education programmes are proliferating. However, while literature clearly outlines the roles and practice of ... [more ▼]

Background: The concept of a ‘specialist nurse’ has existed for many years and related education programmes are proliferating. However, while literature clearly outlines the roles and practice of registered nurses and advanced practice nurses, those of specialist nurses remain unclear and nursing specializations across Europe need clarifying. Aim: This pilot study aimed to explore the competencies, education requirements and regulation of specialist nurses in Europe. Design: A descriptive cross-sectional survey. Methods: An online questionnaire named ‘Specialist nurse and specialization in Europe’ was sent to 550 members of the European Federation of Nurse Educators and ten members of the European Specialist Nurses Organizations. Snowball sampling was then used to build a convenience sample of nurse educators, clinical nurses and specialist nurses, national nursing association members, and chief nursing officers from all European countries. Besides quantitative aspects, responses to open-ended questions were analysed using a qualitative content analysis process. Results: A total of 77 experts from 29 European countries responded to the questionnaire. Findings highlighted variations in titles, levels and length of education, certification, regulation and scope of practice for specialized nurses in Europe. Analysis of the promoted competencies revealed dominant clinical and technical aspects of the role with a high level of knowledge.Conclusions: The study emphasized the need to improve standards for education, certification and regulation for specialist nurses. Interpretation of the role and competencies is diverse with a weak presence of health policy that would enhance and develop the specialities. Implications for nursing and health policy: To address the current lack of provisions for automatic recognition of specialist nurses, common training frameworks corresponding to the relevant level of the European Qualifications Framework should promote lifelong learning and mobility, and enhance levels of health care and patient safety. [less ▲]

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See detailAboveground biomass mapping of African forest mosaics using canopy texture analysis: toward a regional approach.
Bastin, Jean-François ULg; Barbier, Nicolas; Couteron, Pierre et al

in Ecological Applications (2014), 24(8), 1984-2001

In the context of the reduction of greenhouse gas emissions caused by deforestation and forest degradation (the REDD+ program), optical very high resolution (VHR) satellite images provide an opportunity ... [more ▼]

In the context of the reduction of greenhouse gas emissions caused by deforestation and forest degradation (the REDD+ program), optical very high resolution (VHR) satellite images provide an opportunity to characterize forest canopy structure and to quantify aboveground biomass (AGB) at less expense than methods based on airborne remote sensing data. Among the methods for processing these VHR images, Fourier textural ordination (FOTO) presents a good potential to detect forest canopy structural heterogeneity and therefore to predict AGB variations. Notably, the method does not saturate at intermediate AGB values as do pixelwise processing of available space borne optical and radar signals. However, a regional scale application requires to overcome two difficulties: (i) instrumental effects due to variations in sun-scene-sensor geometry or sensor-specific responses that preclude the use of wide arrays of images acquired under heterogeneous conditions and (ii) forest structural diversity including monodominant or open canopy forests, which are of particular importance in Central Africa. In this study, we demonstrate the feasibility of a rigorous regional study of canopy texture by harmonizing FOTO indices of images acquired from two different sensors (Geoeye-1 and QuickBird-2) and different sun-scene-sensor geometries and by calibrating a piecewise biomass inversion model using 26 inventory plots (1 ha) sampled across very heterogeneous forest types. A good agreement was found between observed and predicted AGB (RSE=15%; R²=0.85; p-value<0.001) across a wide range of AGB levels from 26 Mg/ha to 460 Mg/ha, and was confirmed by cross validation. A high-resolution biomass map (100 m pixels) was produced for a 400 km² area, and predictions obtained from both imagery sources were consistent with each other (r=0.86; slope=1.03; intercept=12.01 Mg/ha). These results highlight the horizontal structure of forest canopy as a powerful descriptor of the entire forest stand structure and heterogeneity. In particular, we show that quantitative metrics resulting from such textural analysis offer new opportunities to characterize the spatial and temporal variation of the structure of dense forests and may complement the toolbox used by tropical forest ecologists, managers or REDD+ national monitoring, reporting and verification bodies. [less ▲]

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See detailInput of supercritical carbon dioxide to polymer synthesis: an overview
Boyère, Cédric; Jérôme, Christine ULg; Debuigne, Antoine ULg

in European Polymer Journal (2014), 61

The ongoing search for environmentally friendlier alternative to the organic solvents used in chemical processes has led to the development of technologies based on supercritical carbon dioxide (scCO2 ... [more ▼]

The ongoing search for environmentally friendlier alternative to the organic solvents used in chemical processes has led to the development of technologies based on supercritical carbon dioxide (scCO2), which is non-flammable, non-toxic and relatively inert fluid. Polymer chemistry does not escape this trend and last achievements in the field of polymer synthesis in scCO2 are reviewed here. Without claiming to be exhaustive, we go through and discuss the benefits of the main polymerization processes in scCO2 including homogeneous, precipitation, dispersion, suspension and emulsion systems. A particular attention is drawn to water/carbon dioxide emulsion polymerization and to the suited surface active agents. This review also underlines that heterogeneous polymerization based on CO2 is more than a strategy for reducing the ecological footprint of the polymer production but it allows structuring the polymer materials into particles or highly interconnected macroporous networks. [less ▲]

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See detailAbout the Uniform Hölder Continuity of Generalized Riemann Function
Bastin, Françoise ULg; Nicolay, Samuel ULg; Simons, Laurent ULg

in Mediterranean Journal of Mathematics (2014)

In this paper, we study the uniform H\"{o}lder continuity of the generalized Riemann function~$R_{\alpha,\beta}$ (with $\alpha>1$ and $\beta>0$) defined by \[ R_{\alpha,\beta}(x)=\sum_{n=1}^{+\infty}\frac ... [more ▼]

In this paper, we study the uniform H\"{o}lder continuity of the generalized Riemann function~$R_{\alpha,\beta}$ (with $\alpha>1$ and $\beta>0$) defined by \[ R_{\alpha,\beta}(x)=\sum_{n=1}^{+\infty}\frac{\sin(\pi n^\beta x)}{n^\alpha},\quad x\in\mathbb{R}, \] using its continuous wavelet transform. In particular, we show that the exponent we find is optimal. We also analyse the behaviour of~$R_{\alpha,\beta}$ as $\beta$ tends to infinity. [less ▲]

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See detailThe PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium.
Ning, Gang; Bijron, Jonathan G.; Yamamoto, Yusuke et al

in The Journal of pathology (2014), 234

The oviducts contain high-grade serous cancer (HGSC) precursors (serous tubal intraepithelial neoplasia or STINs), which are gamma-H2AXp - and TP53 mutation-positive. Although they express wild-type p53 ... [more ▼]

The oviducts contain high-grade serous cancer (HGSC) precursors (serous tubal intraepithelial neoplasia or STINs), which are gamma-H2AXp - and TP53 mutation-positive. Although they express wild-type p53, secretory cell outgrowths (SCOUTs) are associated with older age and serous cancer; moreover, both STINs and SCOUTs share a loss of PAX2 expression (PAX2n ). We evaluated PAX2 expression in proliferating adult and embryonic oviductal cells, normal mucosa, SCOUTs, Walthard cell nests (WCNs), STINs, and HGSCs, and the expression of genes chosen empirically or from SCOUT expression arrays. Clones generated in vitro from embryonic gynaecological tract and adult Fallopian tube were Krt7p /PAX2n /EZH2p and underwent ciliated (PAX2n /EZH2n /FOXJ1p ) and basal (Krt7n /EZH2n /Krt5p ) differentiation. Similarly, non-ciliated cells in normal mucosa were PAX2p but became PAX2n in multi-layered epithelium undergoing ciliated or basal (WCN) cell differentiation. PAX2n SCOUTs fell into two groups: type 1 were secretory or secretory/ciliated with a 'tubal' phenotype and were ALDH1n and beta-cateninmem (membraneous only). Type 2 displayed a columnar to pseudostratified (endometrioid) phenotype, with an EZH2p , ALDH1p , beta-cateninnc (nuclear and cytoplasmic), stathminp , LEF1p , RCN1p , and RUNX2p expression signature. STINs and HGSCs shared the type 1 immunophenotype of PAX2n , ALDH1n , beta-cateninmem , but highly expressed EZH2p , LEF1p , RCN1p , and stathminp . This study, for the first time, links PAX2n with proliferating fetal and adult oviductal cells undergoing basal and ciliated differentiation and shows that this expression state is maintained in SCOUTs, STINs, and HGSCs. All three entities can demonstrate a consistent perturbation of genes involved in potential tumour suppressor gene silencing (EZH2), transcriptional regulation (LEF1), regulation of differentiation (RUNX2), calcium binding (RCN1), and oncogenesis (stathmin). This shared expression signature between benign and neoplastic entities links normal progenitor cell expansion to abnormal and neoplastic outgrowth in the oviduct and exposes a common pathway that could be a target for early prevention. Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [less ▲]

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See detailThe construction of workers’ rights consciousness through legal intermediations: the case of employment discrimination in Belgium
Lejeune, Aude ULg; Orianne, Jean-François ULg

in International Journal of Discrimination and the Law (2014), 14(4), 221-243

Through their different encounters with union, court, and government equality agency lawyers, workers report diverse understandings of their personal experience of injustice in the workplace. This paper ... [more ▼]

Through their different encounters with union, court, and government equality agency lawyers, workers report diverse understandings of their personal experience of injustice in the workplace. This paper examines workers’ experiences of discrimination and the role legal professionals play in litigating these issues in Belgium. Bringing together legal and rights consciousness studies and the sociology of intermediation and tracking different stages in the construction of discrimination cases, from the moment when a future litigant describes an event as an injustice to the moment when the judge recognises a discriminatory behaviour (or conversely, dismisses a case), we suggest several possible empirical explanations of the way in which interactions with legal intermediaries affect workers’ rights consciousness. Because we refer to socio-legal studies from common law countries, this paper also calls into question how best to import these studies to assist in analysing legal mobilisations and legal consciousness in continental Europe. [less ▲]

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See detailLa place des savoirs dans l'approche par compétences
Simons, Germain ULg

in Education & Formation (2014), e-302

Ce texte est une mise en perspective de l'axe 1 du n° e-302 de la revue Education & Formation consacré à la publication des actes du colloque d'ABC-Educ (octobre 2013).

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See detailA global analysis of Spitzer and new HARPS data confirms the loneliness and metal-richness of GJ 436 b
Lanotte, Audrey ULg; Gillon, Michaël ULg; Demory, B.-O. et al

in Astronomy and Astrophysics (2014), 572

Context. GJ 436b is one of the few transiting warm Neptunes for which a detailed characterisation of the atmosphere is possible, whereas its non-negligible orbital eccentricity calls for further ... [more ▼]

Context. GJ 436b is one of the few transiting warm Neptunes for which a detailed characterisation of the atmosphere is possible, whereas its non-negligible orbital eccentricity calls for further investigation. Independent analyses of several individual datasets obtained with Spitzer have led to contradicting results attributed to the different techniques used to treat the instrumental effects. Aims. We aim at investigating these previous controversial results and developing our knowledge of the system based on the full Spitzer photometry dataset combined with new Doppler measurements obtained with the HARPS spectrograph. We also want to search for additional planets. Methods. We optimise aperture photometry techniques and the photometric deconvolution algorithm DECPHOT to improve the data reduction of the Spitzer photometry spanning wavelengths from 3-24 {\mu}m. Adding the high precision HARPS radial velocity data, we undertake a Bayesian global analysis of the system considering both instrumental and stellar effects on the flux variation. Results. We present a refined radius estimate of RP=4.10 +/- 0.16 R_Earth, mass MP=25.4 +/- 2.1 M_Earth and eccentricity e= 0.162 +/- 0.004 for GJ 436b. Our measured transit depths remain constant in time and wavelength, in disagreement with the results of previous studies. In addition, we find that the post-occultation flare-like structure at 3.6 {\mu}m that led to divergent results on the occultation depth measurement is spurious. We obtain occultation depths at 3.6, 5.8, and 8.0 {\mu}m that are shallower than in previous works, in particular at 3.6 {\mu}m. However, these depths still appear consistent with a metal-rich atmosphere depleted in methane and enhanced in CO/CO2, although perhaps less than previously thought. We find no evidence for a potential planetary companion, stellar activity, nor for a stellar spin-orbit misalignment. [ABRIDGED] [less ▲]

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See detailEnfants en situation de vulnérabilité médico-psycho-sociale repérés par la médecine scolaire : les oubliés du réseau de soins ?
Noirhomme-Renard, Florence ULg; Bullens, Quentin ULg; Malchair, Alain ULg et al

in Revue Médicale de Liège (2014), 69(12),

Les besoins actuels de santé des enfants sortent largement du cadre biomédical. La prise en compte des déterminants sociaux de la santé dans la surveillance des enfants offre au médecin scolaire un poste ... [more ▼]

Les besoins actuels de santé des enfants sortent largement du cadre biomédical. La prise en compte des déterminants sociaux de la santé dans la surveillance des enfants offre au médecin scolaire un poste « vigie » pour le repérage d’enfants en situation de vulnérabilité, qui le conduit à la nécessité d’un réel « travail en réseau » pour concourir au développement harmonieux de l’enfant. [less ▲]

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See detailNatural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.
Langers, Inge ULg; Renoux, Virginie; Reschner, Anca et al

in European journal of immunology (2014), 44

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since ... [more ▼]

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since NK cells collaborate with dendritic cells (DCs) to induce an immune response against viral infections and tumors, we studied the impact of this crosstalk in the context of HPV vaccination. NK cells in the presence of HPV-VLPs enhanced DC maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10. This activation was bi-directional. Indeed, in the presence of HPV-VLPs, DCs further activated NK cells by inducing the upregulation of cell surface activation markers (CD69 and HLA-DR). The function of NK cells was also improved as shown by an increase in IFN-gamma secretion and cytotoxic activity against an HPV+ cell line. This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated. Our results provide insight into how VLPs interact with innate immune cells and how NK cells and DCs play a role in the immune response induced by this vaccine agent. This article is protected by copyright. All rights reserved. [less ▲]

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See detailLa vernacularización de la conservación en los territorios indígenas amazónicos. Un análisis de la revalorización ancestral indígena en dos proyectos de ecoturismo comunitario en áreas protegidas
Marquez Guerra, José Francisco ULg

in Boletín de Antropología Universidad de Antioquia (2014), 29(48), 92-118

Bolivia adopted the international regime for the conservation of biodiversity in the 90s, while cultural diversity was implementing policies for the indigenous peoples of the lowlands. This two-way ... [more ▼]

Bolivia adopted the international regime for the conservation of biodiversity in the 90s, while cultural diversity was implementing policies for the indigenous peoples of the lowlands. This two-way process was crystallized in a new form of state intervention in the Amazon Region through the implementation of Protected Areas on previously inhabited territories. Based on protection criteria of "nature" and revitalization of the ancient cultures, management areas support sustainable economic development initiative for the locals. From two experiences of indigenous community tourism projects in protected areas, we use the concept of vernacularization of norms to understand how, through these dispositive of generating local income with "low environmental impact", the principles of conservation and sustainable development try to be translated into life forms of three Amazonian people, the Quechua-Tacana Uchupiamonas San Jose, Tsimane 'and Mosetene Pilon Lajas. [less ▲]

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See detailThree sub-Jupiter-mass planets: WASP-69b & WASP-84b transit active K dwarfs and WASP-70Ab transits the evolved primary of a G4+K3 binary
Anderson, D. R.; Collier Cameron, A.; Delrez, Laetitia ULg et al

in Monthly Notices of the Royal Astronomical Society (2014), 445(2),

We report the discovery of the transiting exoplanets WASP-69b, WASP-70Ab and WASP-84b, each of which orbits a bright star (V ˜ 10). WASP-69b is a bloated Saturn-mass planet (0.26 MJup, 1.06 RJup) in a 3 ... [more ▼]

We report the discovery of the transiting exoplanets WASP-69b, WASP-70Ab and WASP-84b, each of which orbits a bright star (V ˜ 10). WASP-69b is a bloated Saturn-mass planet (0.26 MJup, 1.06 RJup) in a 3.868-d period around an active, ˜1-Gyr, mid-K dwarf. ROSAT detected X-rays 60±27 arcsec from WASP-69. If the star is the source then the planet could be undergoing mass-loss at a rate of ˜1012 g s-1. This is one to two orders of magnitude higher than the evaporation rate estimated for HD 209458b and HD 189733b, both of which have exhibited anomalously large Lyman alpha absorption during transit. WASP-70Ab is a sub-Jupiter-mass planet (0.59 MJup, 1.16 RJup) in a 3.713-d orbit around the primary of a spatially resolved, 9-10-Gyr, G4+K3 binary, with a separation of 3.3 arcsec (>=800 au). WASP-84b is a sub-Jupiter-mass planet (0.69 MJup, 0.94 RJup) in an 8.523-d orbit around an active, ˜1-Gyr, early-K dwarf. Of the transiting planets discovered from the ground to date, WASP-84b has the third-longest period. For the active stars WASP-69 and WASP-84, we pre-whitened the radial velocities using a low-order harmonic series. We found that this reduced the residual scatter more than did the oft-used method of pre-whitening with a fit between residual radial velocity and bisector span. The system parameters were essentially unaffected by pre-whitening. [less ▲]

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See detailTravail de différentes disciplines collectives sous forme de circuit
Masrouki, Monia; Cloes, Marc ULg

in Revue de l'Education Physique (2014), 54(4), 101-110

In Wallonia, when teaching team sports, secondary school level physical education teachers generally use a traditional (technicist) and single discipline approach. Moreover, teachers meet some ... [more ▼]

In Wallonia, when teaching team sports, secondary school level physical education teachers generally use a traditional (technicist) and single discipline approach. Moreover, teachers meet some difficulties to apply the accountability and literacy principles. In this paper, authors present a practical example of PE lesson demonstrating that it is possible to change teaching. [less ▲]

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See detailDietary early-life exposure to contaminated eels does not impair spatial cognitive performances in adult offspring mice as assessed in the Y-maze and the Morris water maze
Dridi, Imen; Leroy, Delphine; Guignard, Cedric et al

in Nutrition Research (2014), 34(12), 1075-1084

Many environmental contaminants are introduced via the diet and may act as neurotoxins and endocrine disrupters, especially influencing growing organisms in early life. The purpose of this study was to ... [more ▼]

Many environmental contaminants are introduced via the diet and may act as neurotoxins and endocrine disrupters, especially influencing growing organisms in early life. The purpose of this study was to examine whether dietary exposure of dams to fish naturally contaminated with xenobiotics, especially with polychlorinated biphenyls (PCBs) and heavy metals (e.g. mercury and lead), resulted in cognitive function deficits in adult offspring mice. Daily, four groups of dams (n = 10/group) ingested standard diet plus paste with/without eels, during gestation and lactation, from gestational day (GD) six until post natal day (PND) 21 (weaning). Dams orally ingested a standardized amount of eel (0.8 mgkg-1 d-1) containing the six non-dioxin-like (NDL) PCBs (σ6 NDL-PCBs: 28, 52, 101, 138, 153, and 180) at 0, 85, 216, and 400 ngkg-1 d-1. Results showed that early-life exposure to contaminated eels did not (compared to non-exposed controls) impair immediate working memory in the Y-maze in the offspring assessed at PND 38. Furthermore, it did not significantly impact spatial learning and retention memory as measured in the Morris water maze in adult offspring mice (PND 120-123). Our results suggest that perinatal exposure to contaminated eels does not affect spatial cognitive performances, as assessed by the Y-maze and Morris water maze at adult age. Adverse effects of xenobiotics reported earlier might be camouflaged by beneficial eel constituents, such as n-3 fatty acids. However, additional studies are needed to differentiate between potential positive and negative effects following consumption of food items both rich in nutrients and contaminants. © 2014 Elsevier Inc. [less ▲]

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