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See detailGammapathie monoclonale de signification indéterminée : information destinée aux médecins référents
CAERS, Jo ULg; Binsfeld, Marilène ULg; Muller, Joséphine ULg et al

in Revue Médicale de Liège (in press)

Les gammapathies monoclonales de signification indéterminée (GMSI) sont fréquentes dans la population générale. Leur potentiel évolutif malin impose une surveillance clinique régulière et prolongée ... [more ▼]

Les gammapathies monoclonales de signification indéterminée (GMSI) sont fréquentes dans la population générale. Leur potentiel évolutif malin impose une surveillance clinique régulière et prolongée. Cependant, les GMSI forment un groupe très hétérogène et tous les patients n’ont pas le même risque de transformation maligne. Plusieurs critères biologiques simples, disponibles en routine ont été identifiés comme facteurs prédictifs de la transformation. Les scores prédictifs de transformation maligne combinant plusieurs de ces facteurs permettront probablement la classification des patients en fonction de leur risque évolutif. La prise en charge pourra ainsi être adaptée au risque individuel de chaque patient [less ▲]

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See detailSome misunderstood or unknown tricks (XIII) (LaTeX)
Merciadri, Luca ULg

in TUGboat (in press)

We will here again consider many tips and tricks. This time, they will mostly come from Glad Deschrijver, TeX Tricks, 2011. (http://users.ugent.be/~gdschrij/LaTeX/textricks.html.) Tricks: vertically ... [more ▼]

We will here again consider many tips and tricks. This time, they will mostly come from Glad Deschrijver, TeX Tricks, 2011. (http://users.ugent.be/~gdschrij/LaTeX/textricks.html.) Tricks: vertically aligned itemize environments, allowing linebreaks after comma in math mode, writing under and over elements, and using stacks, footnotes with a new number at each section, footnotes in tabular, splitting algorithm environments on multiple pages, let " produce opening/closing quotation marks, indenting some text but not the first line, using diagonal dots positioned according to the opposite diagonal, using a centered verbatim environment, drawing a table with dashed lines, shaded cells and arrows pointing at a row and a column, correct spacing around square brackets (used for sets) in math mode. [less ▲]

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See detailExpression microarray as a tool to identify candidate blood biomarkers in horses suffering from inflammatory airway disease
Ramery, Eve ULg; Fraipont, Audrey ULg; Art, Tatiana ULg et al

in Veterinary Clinical Pathology (in press)

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires ... [more ▼]

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires sedation. Objectives: The purpose of this study was to identify candidate blood biomarkers of IAD using species-specific expression microarrays. Methods: Horse Gene Expression Microarrays were used to investigate global mRNA expression in circulating leukocytes from healthy and IAD-affected standardbreds and endurance horses. Results: Nine genes were significantly differentially regulated in standardbreds and 61 in endurance horses (P < 0.001). These genes were mainly related to inflammation (eg. ALOX15B, PLA2G12B and PENK), oxidant/antioxidant balance (eg. DUOXA2 and GSTO1-1) and stress (eg. V1aR, GRLF1, Homer-2 and MAOB). DUOXA2, ALOX15B, PLA2G12B, MAOB and GRLF1 variations of expression were further validated by RT-qPCR. The deregulation of the oxidant/antioxidant balance was demonstrated at the protein level by an increase of glutathione peroxidase (GPx) activity in heparinised whole blood of IAD-affected standardbreds (P = 0.0025) and endurance horses (P = 0.0028). There was good correlation (r = 0.7354) between BAL neutrophil percentage and whole blood GPx activity in all horses. Conclusions: There is accumulating evidence that, even when systemic clinical signs are not evident, circulating leukocyte gene expression can reflect responses of other tissues, leading to potential diagnostic applications in the future. Although not specific for IAD, whole blood GPx activity appears to reflect BAL neutrophil percentage. This finding should be further assessed by testing a larger number of horses. [less ▲]

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See detailSome misunderstood or unknown tricks (XI) (LaTeX) and encoding issues (II)
Merciadri, Luca ULg

in TUGboat (in press)

Three subjects will be detailed: 1. Using LaTeX syntax as an unambiguous way to communicate, 2. Writing a bold \ell, 3. Fonts' encodings.

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See detailPIXE identification of the provenance of ferruginous rocks used by Neanderthals
Mathis, François ULg; Bodu, Pierre; Dubreuil, Olivier ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (in press)

Les Bossats, near Ormesson, France, is a newly discovered late Mousterian open air site dated to around 47,000 years ago by thermoluminescence. The archaeological level, fossilized by loess, revealed a ... [more ▼]

Les Bossats, near Ormesson, France, is a newly discovered late Mousterian open air site dated to around 47,000 years ago by thermoluminescence. The archaeological level, fossilized by loess, revealed a rich industry based on the discoid mode, associated with numerous fragments of red and yellow iron oxide-rich rocks showing clear traces of powder production (abrasion, striation, scraping), which are exceptional remains for this remote period. Archeological material and geological samples from the close environment were studied by PIXE and by petrographical observations made on thin sections. The geological sources were identified by means of PIXE analyses on two IBA facilities: AGLAE (2 MV tandem) at the C2RMF in Paris and the cyclotron of the IPNAS (University of Liège). We paid particular attention to the comparison of results obtained on both installations by using the same set of geological standards and by a fine evaluation of the limit of detection relative to each trace elements of interest for both experimental set ups. The elemental fingerprint of one geological source of iron-rich concretions corresponds clearly with the archaeological collection. At least, this investigation demonstrates that the colouring materials were minutely selected in the close neighbouring of the site by the Neanderthals. [less ▲]

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See detailContribution à un lexique épigraphique: "deltographéma"
Famerie, Etienne ULg

in Zeitschrift für Papyrologie und Epigraphik (in press)

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See detailCharacterizing the morphology of suburban settlements: a method based on a semi-automatic classification of building clusters
de Smet, Fabian; Teller, Jacques ULg

in Landscape Research (in press)

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of ... [more ▼]

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of much debate amongst scientists. The present article takes the view that, beyond measuring and delineating suburban areas, more efforts should be directed to qualifying the morphology of built settlements within these areas. Therefore it proposes a method based on a semi-automatic classification system of building clusters, designed to describe and interpret the phenomenon from a morphological perspective. This method is based on a combination of field surveys with numerical analyses of digital land cadastre maps. The application of this classification system to the suburban area around Liege reveals that, far from developing in a complete indifference of local conditions, contemporary suburban settlements are influenced by landscape structures inherited from the past. [less ▲]

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See detailVehicle routing problems with loading constraints: State-of-the-art and future directions
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in OR Spectrum (in press)

Distributors are faced with loading constraints in their route planning. These loading constraints include multi-dimensional packing constraints, unloading sequence constraints, stability constraints and ... [more ▼]

Distributors are faced with loading constraints in their route planning. These loading constraints include multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Not taking into account these loading constraints would make the planning often not feasible in practice and gives rise to last-minute changes in planning which may result in additional costs. The development of vehicle routing models that incorporate loading constraints is vital for a more efficient planning of routes. The number of contributions to this field of research has increased enormously in the last couple of years. Almost sixty percent of the papers that study the integration of loading constraints in routing models are published after 2009. The contribution of this paper is twofold. First, an overview of recent developments in this research field is provided. Literature on all transport modes in which loading constraints play a key role is discussed (trucks, airplanes, ships, and automated guided vehicles). To identify the loading constraints considered in each paper, a state-of-the-art classification scheme on loading problems is used. Second, research gaps and opportunities for future research are identified. [less ▲]

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See detailAIR VERSUS GROUND TRANSPORT OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: EXPERIENCE IN A RURAL-BASED HELICOPTER MEDICAL SERVICE
MOENS, Didier ULg; Stipulante, Samuel ULg; Donneau, Anne-Françoise ULg et al

in European Journal of Emergency Medicine (in press)

Aims Primary pre-hospital Helicopter Emergency Medical Service (HEMS) interventions may play a role in timely reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI). We ... [more ▼]

Aims Primary pre-hospital Helicopter Emergency Medical Service (HEMS) interventions may play a role in timely reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI). We designed a prospective study involving patients with acute myocardial infarction aimed at the evaluation of the potential benefit of such primary HEMS interventions as compared with classical EMS ground transport. Methods & results This prospective study was conducted from July 1, 2007 to June 15, 2012. Successive patients with ST-segment elevation myocardial infarction (STEMI) eligible for percutaneous coronary intervention (PCI) were included. Simulated ground-based access times were computed using a digital cartographic program, allowing the estimation of healthcare system delay from call to admission to the catheterisation laboratory. During the study period, 4485 patients benefited from HEMS activations. Of these patients, 342 (8%) suffering from STEMI were transferred for primary PCI. Median primary response time time was 11 min (IQR: 8 - 14 min) using the helicopter and 32 min (25 – 44 min) using road transport. Median transport time using HEMS was 12 min (9 – 15 min) and 50 min (36 – 56 min) by road. The median system delay using HEMS was 52 min (45 – 60 min), while this time was 110 min (95 – 126 min) by road. Finally, the system delay median gain was 60 min (47 – 72 min). Conclusions Using HEMS in a rural region allows STEMI patients to benefit from appropriate rescue care with similar delays as those seen in urban patients. [less ▲]

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See detailSur Capitalisme, désir et servitude. Lettre à Frédéric Lordon
Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailPilgrimage Certificates from the Mamluk Period: New Data
Bauden, Frédéric ULg

in Bulletin of the School of Oriental and African Studies (in press)

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See detailCircadian and circannual variations in cord blood hematopoietic cell composition
Servais, Sophie ULg; BAUDOUX, Etienne ULg; Brichard, B. et al

in Haematologica (in press)

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See detailArsinoe II come dea attraverso le sue epiclesi cultuali
Caneva, Stefano ULg

in Athenaeum : Studii Periodici di Letteratura e Storia (in press)

Dopo una introduzione storica e storiografica sul significato dei culti regali ellenistici, l’intervento esamina alcuni dei nomi divini attribuiti ad Arsinoe II nelle fonti letterarie e documentarie, con ... [more ▼]

Dopo una introduzione storica e storiografica sul significato dei culti regali ellenistici, l’intervento esamina alcuni dei nomi divini attribuiti ad Arsinoe II nelle fonti letterarie e documentarie, con l’eccezione dell’epiclesi esclusiva Philadelphos. Scopo della ricerca è 1) una valutazione delle strategie di inserimento della nuova dea nel pantheon tradizionale; 2) una riflessione sull’autoconsapevolezza degli antichi in relazione alla propria tradizione religiosa, per come essa si manifesta attraverso l’oculata manipolazione di un elemento essenziale nella definizione della divinità, qual è il nome divino. Un’Appendice elenca, in tre tabelle, tutte le denominazioni greche di Arsinoe II (esclusa Philadelphos), fornendo indicazioni sulla fonte, la sua collocazione spaziale e temporale e sulla divinità tradizionale di riferimento. [less ▲]

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See detailThe role of olfaction in wireworms: a review on foraging behavior and sensory apparatus
Barsics, Fanny ULg; Haubruge, Eric ULg; Francis, Frédéric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use ... [more ▼]

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use biotic and abiotic signals to orientate towards target plant organs. Development of efficient techniques for implementation in integrated strategies relies upon improved knowledge of this process. In particular, an important step consists of elucidating the role of volatile organic compounds (VOC), emitted by belowground plant organs, in wireworm chemical ecology. This would have a positive impact on push-pull strategies and varietal selection developed against these insects. Literature In this work, we summarized the available data regarding wireworm foraging behavior as well as variables that should be considered when studying the potential role of plant-produced volatile semiochemicals. This includes CO2 gradients and other host-related cues, temperature, relative humidity and soil moisture, and wireworm physiological stage. We also review what is known of the sensory apparatus of wireworms, since this is involved in every step of the foraging process. Conclusion Some baseline data for studying VOC related wireworm foraging behavior exists. Using it as a tool in applied entomology should result in discovery of the semiochemicals that underpin trophic interactions involving these pests. However, most of the key pest species are not fully described with regards to the parameters detailed here. Obtaining accurate information to fill the current knowledge gaps will be needed in order to devise new integrated management strategies. [less ▲]

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See detailDabigatran Etexilate and Risk of Myocardial Infarction, Other Cardiovascular Events, Major Bleeding, and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Douxfils, Jonathan; Buckinx, Fanny ULg; Mullier, Francois et al

in Journal of the American Heart Association (in press)

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of ... [more ▼]

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of the published literature and a clinical trials registry maintained by the drug manufacturer. Criteria for inclusion in our meta-analysis included all RCTs and the availability of outcome data for MI, other cardiovascular events, major bleeding, and all-cause mortality. Among the 501 unique references identified, 14 RCTs fulfilled the inclusion criteria. Stratification analyses by comparators and doses of dabigatran etexilate were conducted. Peto odds ratio (ORPETO) values using the fixed-effect model (FEM) for MI, other cardiovascular events, major bleeding, and all-cause mortality were 1.34 (95% CI 1.08 to 1.65, P=0.007), 0.93 (95%CI 0.83 to 1.06, P=0.270), 0.88 (95% CI 0.79 to 0.99, P=0.029), and 0.89 (95% CI 0.80 to 1.00, P=0.041). When compared with warfarin, ORPETO values using FEM were 1.41 (95% CI 1.11 to 1.80, P=0.005), 0.94 (95%CI 0.83 to 1.06, P=0.293), 0.85 (95% CI 0.76 to 0.96, P=0.007), and 0.90 (95% CI 0.81 to 1.01, P=0.061), respectively. In RCTs using the 150-mg BID dosage, the ORPETO values using FEM were 1.45 (95% CI 1.11 to 1.91, P=0.007), 0.95 (95% CI 0.82 to 1.09, P=0.423), 0.92 (95% CI 0.81 to 1.05, P=0.228), and 0.88 (95% CI 0.78 to 1.00, P=0.045), respectively. The results of the 110-mg BID dosage were mainly driven by the RE-LY trial. CONCLUSIONS: This meta-analysis provides evidence that dabigatran etexilate is associated with a significantly increased risk of MI. This increased risk should be considered taking into account the overall benefit in terms of major bleeding and all-cause mortality. [less ▲]

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See detailÉtude des contraintes mécaniques locomotrices chez le cheval
Noble, Prisca ULg; Collin, Bernard ULg; Denoix, Jean-Marie et al

in Annales de Médecine Vétérinaire (in press)

In locomotor biomechanics, three high groups of contraints are commonly encountared : pressure, traction and torsion. In supra-maximal conditions, all of these contraints would be responsible of some ... [more ▼]

In locomotor biomechanics, three high groups of contraints are commonly encountared : pressure, traction and torsion. In supra-maximal conditions, all of these contraints would be responsible of some equine diseased locomotor systems. In order to understand better the contraints in the equine locomotor dynamics, some investigations have been carried out. Moreover, some measurement methods, based on the mechanics of Newton, have been performed. This review shows the different measurement techniques and introduces the mechanical basis that are compulsory for the understanding of the equine locomotor apparatus functioning. [less ▲]

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See detailLa première interprétation heideggérienne de la Monadologie
Pieron, Julien ULg

in Philosophie (in press)

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See detailA review of inversion techniques related to the use of relationship matrices in animal breeding
Faux, Pierre ULg; Gengler, Nicolas ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

In animal breeding, prediction of genetic effects is usually obtained through the use of mixed models. For any of these genetic effects, mixed models require the inversion of the covariance matrix ... [more ▼]

In animal breeding, prediction of genetic effects is usually obtained through the use of mixed models. For any of these genetic effects, mixed models require the inversion of the covariance matrix associated to that effect, which is equal to the associated relationship matrix times the associated component of the genetic variance. Given the size of many genetic evaluation systems, computing the inverses of these relationship matrices is not trivial. In this review, we aim to cover computational techniques that ease inversion of relationship matrices used in animal breeding for prediction of the following different types of genetic effects: additive effect, gametic effect, effect due to presence of marked quantitative trait loci, dominance effect and different epistasis effects. Construction rules and inversion algorithms are detailed for each relationship matrix. In the final discussion, we draw up a common theoretical frame to most of the reviewed techniques. Two computational constraints come out of this theoretical frame: setting up the matrix of dependencies between levels of the effect and setting up some parts (diagonal or block-diagonal elements) of the relationship matrix to be inverted. [less ▲]

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See detailA global analysis of Spitzer and new HARPS data confirms the loneliness and metal-richness of GJ 436 b
Lanotte, Audrey ULg; Gillon, Michaël ULg; Demory, B.-O. et al

in Astronomy and Astrophysics (in press)

Context. GJ 436b is one of the few transiting warm Neptunes for which a detailed characterisation of the atmosphere is possible, whereas its non-negligible orbital eccentricity calls for further ... [more ▼]

Context. GJ 436b is one of the few transiting warm Neptunes for which a detailed characterisation of the atmosphere is possible, whereas its non-negligible orbital eccentricity calls for further investigation. Independent analyses of several individual datasets obtained with Spitzer have led to contradicting results attributed to the different techniques used to treat the instrumental effects. Aims. We aim at investigating these previous controversial results and developing our knowledge of the system based on the full Spitzer photometry dataset combined with new Doppler measurements obtained with the HARPS spectrograph. We also want to search for additional planets. Methods. We optimise aperture photometry techniques and the photometric deconvolution algorithm DECPHOT to improve the data reduction of the Spitzer photometry spanning wavelengths from 3-24 {\mu}m. Adding the high precision HARPS radial velocity data, we undertake a Bayesian global analysis of the system considering both instrumental and stellar effects on the flux variation. Results. We present a refined radius estimate of RP=4.10 +/- 0.16 R_Earth, mass MP=25.4 +/- 2.1 M_Earth and eccentricity e= 0.162 +/- 0.004 for GJ 436b. Our measured transit depths remain constant in time and wavelength, in disagreement with the results of previous studies. In addition, we find that the post-occultation flare-like structure at 3.6 {\mu}m that led to divergent results on the occultation depth measurement is spurious. We obtain occultation depths at 3.6, 5.8, and 8.0 {\mu}m that are shallower than in previous works, in particular at 3.6 {\mu}m. However, these depths still appear consistent with a metal-rich atmosphere depleted in methane and enhanced in CO/CO2, although perhaps less than previously thought. We find no evidence for a potential planetary companion, stellar activity, nor for a stellar spin-orbit misalignment. [ABRIDGED] [less ▲]

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See detailSiting Controversies Analysis: Framework and Method for Questioning the Procedure
Rossignol, Nicolas ULg; Parotte, Céline ULg; Joris, Geoffrey ULg et al

in Journal of Risk Research (in press)

Siting controversies are commonplace, as well against the construction of roads, railways, nuclear waste disposals, as against windfarms. Local citizens resist against siting decisions taken by the ... [more ▼]

Siting controversies are commonplace, as well against the construction of roads, railways, nuclear waste disposals, as against windfarms. Local citizens resist against siting decisions taken by the authorities, following a dynamics often quoted as ‘Not In My Back Yard’. Yet contested for its lack of analytical value, NIMBY is still used strategically by actors to qualify citizens as irrational and egoistic. Beyond this labelling, many factors are investigated to understand the dynamics behind siting controversies. In this paper, we focus on the impact of the legal procedure structuring the implantation of windfarms in the Walloon Region (Belgium), and its translations within different decision making processes in specific case studies. To that regard, we consider the legal procedure as a ‘public policy instrument’. It is neither neutral nor natural, and carry values and interests. It organizes inter-personal relations between actors, and is potentially catalyzer of frustrations. In addition, this legal procedure is the object of translations within different contexts, including different actors participating to specific decision making processes. The empirical approach of this paper is based on case studies data and on the use of an innovative methodology called ‘Open Process Workshop’. This methodology consists in a structured workshop with key stakeholders, during which the legal procedure is questioned. Overall, we demonstrate that the focus on the legal procedure - and its translations within different decision making processes - allows systemic analysis providing deep understandings of controversies and reaffirming the interlinks between ‘the social’ and ‘the technical’ in such controversies. In addition, we argue that the methodology used fosters the production of innovative knowledge, mutual understanding and collective learning between the participants. [less ▲]

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See detailIsotopic tracing of sediment components that are assimilated by epibiontic juveniles of Holothuria scabra (Holothuroidea)
Plotieau, Thomas; Lepoint, Gilles ULg; Lavitra, Thiery et al

in Journal of the Marine Biological Association of the United Kingdom (in press)

Despite H. scabra’s wide distribution and status as one of the best candidates for sustaining the development of tropical sea cucumber aquaculture, very few data are available regarding the organic ... [more ▼]

Despite H. scabra’s wide distribution and status as one of the best candidates for sustaining the development of tropical sea cucumber aquaculture, very few data are available regarding the organic fraction it assimilates in practice. In this study we report experimental results where H. scabra’s diet was supplemented with various 15N-labelled organic fractions of sediment. We used juveniles weighing between 38- 88 mg at the beginning of the experiment (ca. 2 cm long and 30 days old). Their growth was measured over a four week period and their 15N composition recorded. The results showed that H. scabra juveniles assimilated all added organic components from both dissolved and particulate fractions of the sediment. Bacteria seem to be an important food source for juveniles, even more so than microphytobenthos (diatoms). [less ▲]

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See detailIdentification of cardiac repercussions after intense and prolonged concentric isokinetic exercise in young sedentary people.
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Couffignal, Vincent et al

in Clinical physiology and functional imaging (in press)

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among ... [more ▼]

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among those who are unaware of their heart condition. The development of cardiospecific biochemical markers has led to a reconsideration of the role of biology in the diagnosis of cardiovascular illnesses. The aim of this study therefore was, through the use of cardiac biomarker assays, to highlight the impact of sustained physical effort in the form of intense and prolonged concentric isokinetic exercise and to research potential cardiovascular risks. MATERIALS AND METHODS: Eighteen subjects participated in a maximal concentric isokinetic exercise involving 30 knee flexion-extensions for each leg. Five blood tests were taken to study the kinetics of the cardiac biomarkers. Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: The results showed significant increases in the creatine kinase, myoglobin, homocysteine and haemoglobin cardiac markers. Evolutionary trends were also observed for the following biomarkers: NT-proBNP, myeloperoxydase and C-reactive protein. All the physiological parameters measured presented statistically significant changes. CONCLUSION: Isokinetic effort leads to the release of cardiac markers in the blood, but these do not exceed the reference values in healthy subjects. Maximal concentric isokinetic exercise does not, therefore, lead to an increased risk of cardiovascular pathologies. [less ▲]

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See detailThe open-air site of Tolbor 16 (Northern Mongolia): preliminary results and perspectives
Zwyns, N.; Gladyshev; Gunchinsuren, B. et al

in Quaternary International (in press)

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See detailA Double-Blind, Placebo Controlled, Randomized Trial to Assess the Impact of a Monthly Administration of 50,000 IU of Vitamin D3 for 6 Months on Serum Levels of 25-Hydroxyvitamin D in Healthy Young Adults
Brunel, Elodie ULg; SCHNITZLER, Maryline ULg; Foidart-Dessalle, Marguerite ULg et al

in International Journal of Endocrinology (in press)

In this double blind, unicentre, randomized, placebo controlled study, we evaluated the changes in 25-hydroxyvitamin D (25(OH)D) serum levels in 150 young Belgian adults (18–30 years), monthly ... [more ▼]

In this double blind, unicentre, randomized, placebo controlled study, we evaluated the changes in 25-hydroxyvitamin D (25(OH)D) serum levels in 150 young Belgian adults (18–30 years), monthly supplemented with 50,000 IU of vitamin D (VTD) or placebo for 6 months, from November 2010 to May 2011. At T0, 30% of the population presented 25(OH)D serum levels below 20 ng/mL. In the VTD-treated group, mean serum levels increased from 21.2 ± 8.2 to 30.6 ± 8.8 ng/mL (𝑃 < 0.001) at T3mo and to 36.0 ± 9.2 ng/mL (𝑃 < 0.001) at T6mo. Despite documented VTD intake, no changes in serum levels were, however, observed in 10% of the treated group. In the placebo group, mean 25(OH)D serum levels decreased from22.8 ± 8.5 to 14.0 ± 6.9 ng/mL at T3mo (𝑃 < 0.001) but returned to values not significantly different from those observed at T0 (23.5 ± 8.6 ng/mL) at T6mo. No difference between serum calcium levels was observed between the groups throughout the study. In conclusion, monthly supplementation with50,000UIofVTDinwinter canwarrant serum25(OH)Dlevels above 20ng/mL in96.2%of thosehealthy young adultswithout inducing unacceptably high 25(OH)D concentration. This supplementation is safe andmay be proposed without 25(OH)D testing. [less ▲]

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See detailEffect of bovine colostrum intake on growth, reproductive parameters and survival in red kids
Harouna, Abdou; Marichatou, Hamani; Beckers, Jean-François ULg et al

in Journal of Animal Physiology & Animal Nutrition (in press)

The aim of this study is to evaluate the efficacy of frozen Azawak colostrum supplementation on body weight (BW), average daily gain (ADG), reproductive parameters (mean age at first parturition ... [more ▼]

The aim of this study is to evaluate the efficacy of frozen Azawak colostrum supplementation on body weight (BW), average daily gain (ADG), reproductive parameters (mean age at first parturition, fertility, fecundity, prolificacy) and mortality rate among red kids. The study was conducted at the goat farm secondary centre of Maradi in Niger from September 2010 to September 2011. The control animals (n = 20) were left with their mother, while the treatment animals (n = 20) received in addition 50 ml/animal/day of bovine colostrum at birth and 15 ml/animal/day from d2 to d15. Weight was measured weekly from birth to d365. Mortalities were also recorded over the same period. For reproductive parameters, observations began at weaning (d197). Growth rate was higher (p < 0.001) in supplemented animal, and the treatment effects on ADG were observed up to 150 day after the end of supplementation. A similar long-lasting trend was also observed in relation to the mortality rate (25% for ColG vs. 55% for ConG; p = 0.05). The age at first kidding tended to be lower in the treated group (13.8 0.7 vs. 14.1 0.8 month; p < 0.1). In conclusion, mild bovine colostrum supplementation induces a long-lasting positive impact on growth rate and to a lower extent on reproduction parameters and survival rate. [less ▲]

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See detailUne approche basée objet combinée avec les classifieurs avancés (SVM, RF, Extra Trees) pour la détection des changements du bâti
El Mansouri, Loubna ULg

in Rig (in press)

Cet article expose le développement d’une méthodologie automatique pour la détection des changements du bâti en vue d'une mise à jour semi automatique des cartes urbaines. L'approche est basée sur la ... [more ▼]

Cet article expose le développement d’une méthodologie automatique pour la détection des changements du bâti en vue d'une mise à jour semi automatique des cartes urbaines. L'approche est basée sur la comparaison entre une carte existante et une image à très haute résolution spatiale (THRS) récente. Elle s'enchaine sur 4 étapes. D'abord l'image est segmentée pour produire des primitives. Ces dernières sont caractérisées par 4 catégories d'attributs. Des classifieurs avancés par apprentissage supervisé (CAAS) ont été utilisés dans l'étape de la classification. Le paramétrage optimal de ces classifieurs est obtenu automatiquement par validation croisée en se référant au meilleur taux d'erreur. La prédiction finale des objets est déduite par un combineur de multiples classifieurs (CMC) conçu à partir des 3 meilleurs CAAS. Enfin, une étape de détection des changements permet d'identifier les primitives qui représentent les changements du bâti. Les données utilisées concernent la ville de Rabat (Maroc). Une image QuickBird a été utilisée avec un plan existant à l'échelle 1:10,000. Indépendamment de la qualité de la forme des bâtiments détectés, la méthode offre des meilleurs taux en exhaustivité (91.7%) et en exactitude (81.5%). [less ▲]

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See detailBayesian versus frequentist methods for estimating disease true prevalence and 4 diagnostic test performance
Sanogo, M; Abatih, E; Saegerman, Claude ULg

in Veterinary Journal (in press)

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See detailDifferences in species–area relationships among the major lineages of land plants: a macroecological perspective
Patino Llorente, Jairo ULg; Weigelt, P.; Guilhaumon, F. et al

in Global Ecology & Biogeography (in press)

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See detailA New Shift-Share Method
Artige, Lionel ULg; Van Neuss, Leif ULg

in Growth and Change (in press)

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant ... [more ▼]

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant variable) relative to the national average. This technique has always been subject to criticism for its lack of theoretical basis. This paper presents a critical assessment of the methods suggested by Dunn (1960) and by Esteban-Marquillas (1972) and proposes a new shift-share method, which separates out the two effects unambiguously. By way of illustration, we provide an application to manufacturing employment in the Belgian provinces between 1995 and 2007. [less ▲]

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See detailLa maladie de Lyme entre cadrage infectieux, vectoriel et zoonotique : vers une écologisation des problèmes sanitaires ?
Massart, Clémence ULg

in VertigO : la Revue Electronique en Sciences de l'Environnement (in press)

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ... [more ▼]

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ricinus en Europe ; Ixodes persulcatus en Asie ; Ixodes scapularis aux États-Unis et au Canada). Les médecins et les malades ont d’abord développé un cadrage infectieux, ancré dans la santé humaine, réservé à Lyme et soumis à une vive controverse. Progressivement, un second cadrage vectoriel s’est structuré autour des entomologistes médicaux puis des écologues, généralement étrangers à la problématique des maladies humaines. Axé sur le vecteur, ce cadrage englobe les autres maladies transmises par Ixodes ricinus en Europe qui, durant les 30 dernières années, n’ont cessé d’être découvertes : bartonnelles, babésioses, tularémie, encéphalite à tiques, etc. Combinée à ces nouvelles pathologies, la notoriété de Lyme a finalement contribué à ouvrir la catégorie « transmission vectorielle » – traditionnellement associée aux moustiques des pays tropicaux – aux tiques et aux maladies de l’hémisphère nord qu’elles véhiculent. Un troisième cadrage axé sur les réservoirs et qualifié de zoonotique commence enfin à se dessiner. Il faut reconnaître dans cette juxtaposition des cadrages – infectieux, vectoriel et zoonotique – une forme d’écologisation des problèmes sanitaires. [less ▲]

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See detailA reassessment of the use of Posidonia oceanica and Mytilus galloprovincialis to biomonitor the coastal pollution of trace elements: New tools and tips
Richir, Jonathan ULg; Gobert, Sylvie ULg

in Marine Pollution Bulletin (in press)

The present study gives a summary using state-of-the-art technology to monitor Posidonia oceanica and Mytilus galloprovincialis as bioindicators of the pollution of the Mediterranean littoral with trace ... [more ▼]

The present study gives a summary using state-of-the-art technology to monitor Posidonia oceanica and Mytilus galloprovincialis as bioindicators of the pollution of the Mediterranean littoral with trace elements (TEs), and discusses their complementarity and specificities in terms of TE bioaccumulation. Furthermore, this study presents two complementary indices, the Trace Element Spatial Variation Index (TESVI) and the Trace Element Pollution Index (TEPI): these indices were shown to be relevant monitoring tools since they led to the ordering of TEs according to the overall spatial variability of their environmental levels (TESVI) and to the relevant comparison of the global TE pollution between monitored sites (TEPI). In addition, this study also discusses some underestimated aspects of P. oceanica and M. galloprovincialis bioaccumulation behaviour, with regard to their life style and ecophysiology. It finally points out the necessity of developing consensual protocols between monitoring surveys in order to publish reliable and comparable results. [less ▲]

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See detailGaucher Disease and Bone Manifestations
Marcucci, Gemma; Zimran, Ari; Bembi, Bruno et al

in Calcified tissue international (in press)

Gaucher disease is a relatively rare metabolic disease caused by the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Gaucher disease affects multiple organs, among which is the skeleton ... [more ▼]

Gaucher disease is a relatively rare metabolic disease caused by the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Gaucher disease affects multiple organs, among which is the skeleton. Bone involvement occurs frequently in Gaucher disease, and is one of its most debilitating features, reducing the quality of life of patients. Bone status is an important consideration for treatment to ameliorate symptoms and reduce the risk of irreversible complications. We have conducted a systematic review of all the various aspects of Gaucher disease, focusing on different skeletal manifestations, pathophysiology of bone alterations, clinical symptoms, and current diagnostic and therapeutic approaches. [less ▲]

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See detailComparative biogeochemistry-ecosystem-human interactions on dynamic continental margins
Levin, Lisa A.; Liu, Kon-Kee; Kay-Christian, Emeis et al

in Journal of Marine Systems (in press)

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions ... [more ▼]

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins. [less ▲]

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See detailThe effects of vitamin D on skeletal muscle strength, muscle mass and muscle power: a systematic review and meta-analysis of randomized controlled trials.
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Rabenda, Véronique ULg et al

in The Journal of clinical endocrinology and metabolism (in press)

Context There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle. Objective To summarize with a meta-analyse the effects of vitamin D supplementation on muscle ... [more ▼]

Context There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle. Objective To summarize with a meta-analyse the effects of vitamin D supplementation on muscle function. Data sources A systematic research of randomized controlled trials, performed between 1966 and January 2014 has been conducted on Medline, Cochrane Database of Systematics Reviews, Cochrane Central Register of Controlled and completed by a manual review of the literature and congressional abstracts. Study selection All forms and doses of vitamin D supplementation, with or without calcium supplementation, compared with placebo or control were included. Out of the 225 potentially relevant articles, 30 randomized controlled trials involving 5615 individuals (mean age: 61.1 years) met the inclusion criteria. Data extraction Data were extracted by two independent reviewers. Data synthesis Results revealed a small but significant positive effect of vitamin D supplementation on global muscle strength with a standardized mean difference (SMD) of 0.17 (p=0.02). No significant effect was found on muscle mass (SMD 0.058; p=0.52) or muscle power (SMD 0.057; p=0.657). Results on muscle strength were significantly more important with people who presented a 25-hydroxyvitamin D level <30 nmol/L. Supplementation seems also more effective on people aged 65 years or older compared to younger subjects (SMD 0.25; 95% CI 0.01 to 0.48 versus SMD 0.03; 95% CI -0.08 to 0.14). Conclusions Vitamin D supplementation has a small positive impact on muscle strength but additional studies are needed to define optimal treatment modalities, including dose, mode of administration and duration. [less ▲]

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See detailInfluence of noise correction on intra- and inter-subject variability of quantitative metrics in diffusion kurtosis imaging
André, Elodie ULg; Grinberg, Farida; Farrher, Ezequiel et al

in PLoS ONE (in press)

Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing new biomarkers. Given the rapidly increasing ... [more ▼]

Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing new biomarkers. Given the rapidly increasing number of studies, DKI has a potential to establish itself as a valuable tool in brain diagnostics. However, to become a routine procedure, DKI still needs to be improved in terms of robustness, reliability, and reproducibility. As it requires acquisitions at higher diffusion31 weightings, results are more affected by noise than in diffusion tensor imaging. The lack of standard procedures for post-processing, especially for noise correction, might become a significant obstacle for the use of DKI in clinical routine limiting its application. We considered two noise correction schemes accounting for the noise properties of multichannel phased-array coils, in order to improve the data quality at signal-to-noise ratio (SNR) typical for DKI. The SNR dependence of estimated DKI metrics such as mean kurtosis (MK), mean diffusivity (MD) and fractional anisotropy (FA) is investigated for these noise correction approaches in Monte Carlo simulations and in in vivo human studies. The intra-subject reproducibility is investigated in a single subject study by varying the SNR level and SNR spatial distribution. Then the impact of the noise correction on inter-subject variability is evaluated in a homogeneous sample of 25 healthy volunteers. Results show a strong impact of noise correction on the MK estimate, while the estimation of FA and MD was affected to a lesser extent. Both intra- and inter-subject SNR related variability of the MK estimate is considerably reduced after correction for the noise bias, providing more accurate and reproducible measures. In this work, we have proposed a straightforward method that improves accuracy of DKI metrics. This should contribute to standardization of DKI applications in clinical studies and making valuable inferences in group analysis and longitudinal studies. [less ▲]

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See detailChild labour, Agency and Family dynamics: The Case of Mining in Katanga (DRC)
Andre, Géraldine ULg; Godin, Marie

in Childhood (in press)

In the last three decades, the development of the artisanal and small-scale mining (ASM) sector has been increasing in the Democratic Republic of Congo (DRC), bringing more and more urban families into ... [more ▼]

In the last three decades, the development of the artisanal and small-scale mining (ASM) sector has been increasing in the Democratic Republic of Congo (DRC), bringing more and more urban families into this flourishing business sector, and among them, children. At first glance, one could see children in the mining sector mainly as victims entangled in the flows of raw materials of unbridled capitalism. But this paper aims to look at the often unconceivable, and as a result neglected, social agency of children even when they are involved in stigmatized and prohibited types of child labour. To do so, it relies on the results of a socio-anthropological collective research project on children’s mining activities which was carried out in a small locality called La Ruashi in the city of Lubumbashi (Province of Katanga). The article aims to provide a more comprehensive understanding of what is often normatively only labelled as ‘child labour’ by looking at different spheres of social relations within which children are embedded. Examining the set of social interactions that children have with their families, the broader community and their ‘peers’, several ‘family portraits’ are offered, highlighting a heterogeneity of social interpretations regarding this ‘new’ form of child work. It will be shown that for families from middle-class background, this kind of work is often socially disruptive, at the forefront of inter-generational conflict. As for families from lower classes, social changes induced by children’s mining activities are often better incorporated into the family habitus. Common social changes encountered in all families irrespective of class belonging will also be portrayed, showing the transversal societal impact these ‘new’ forms of child economic activities can provoke at a micro level. [less ▲]

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See detailA European survey on attitudes towards pain and end-of-life issues in locked-in syndrome
Demertzi, Athina ULg; Jox, Ralf J; Racine, Eric et al

in Brain Injury (in press)

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in ... [more ▼]

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in syndrome. Methods: Close-ended survey among conference attendees from 33 European countries. Analysis included chi-square tests and logistic regressions. Results: From the 3332 respondents (33% physicians, 18% other clinicians, 49% other professions; 47% religious), 90% agreed that patients with locked-in syndrome can feel pain. The majority (75%) disagreed with treatment withdrawal, but 56% did not wish to be kept alive if they imagined themselves in this condition (p50.001). Religious and southern Europeans opposed to treatment withdrawal more often than non-religious (p50.001) and participants from the North (p¼0.001). When the locked-in syndrome was compared to disorders of consciousness, more respondents endorsed that being in a chronic locked-in syndrome was worse than being in a vegetative state or minimally conscious state for patients (59%) than they thought for families (40%, p50.001). Conclusions: Personal characteristics mediate opinions about locked-in syndrome. The dissociation between personal preferences and general opinions underlie the difference in perspective in disability. Ethical responses to dilemmas involving patients with locked-in syndrome should consider the diverging ethical attitudes of stakeholders. [less ▲]

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See detailSouthern Ocean CO2 sink: The contribution of the sea ice
Delille, Bruno ULg; Vancoppenolle, M; Geilfus, N.-X. et al

in Journal of Geophysical Research. Oceans (in press)

We report first direct measurements of the partial pressure of CO2 (pCO2) within Antarctic pack sea ice brines and related CO2 fluxes across the air-ice interface. From late winter to summer, brines ... [more ▼]

We report first direct measurements of the partial pressure of CO2 (pCO2) within Antarctic pack sea ice brines and related CO2 fluxes across the air-ice interface. From late winter to summer, brines encased in the ice change from a CO2 large over-saturation, relative to the atmosphere, to a marked under-saturation while the underlying oceanic waters remains slightly oversaturated. The decrease from winter to summer of pCO2 in the brines is driven by dilution with melting ice, dissolution of carbonate minerals crystals and net primary production. As the ice warms, its permeability increases, allowing CO2 transfer at the air-sea ice interface. The sea ice changes from a transient source to a sink for atmospheric CO2. We upscale these observations to the whole Antarctic sea-icesea ice cover using the NEMO-LIM3 large-scale sea ice-ocean, and provide first estimates of spring and summer CO2 uptake from the atmosphere by Antarctic sea ice. Over the spring-summer period, the Antarctic sea-icesea ice cover is a net sink of atmospheric CO2 of 0.029 PgC, about 58% of the estimated annual uptake from the Southern Ocean. Sea ice then contributes significantly to the sink of CO2 of the Southern Ocean. [less ▲]

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See detailArrêts sur images – usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un ... [more ▼]

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un défilement réglé (24 photogrammes/seconde) par le dispositif technique du cinéma. Image paradoxale en ce qu’elle reste invisible au spectateur malgré sa force iconique, le photogramme trouve cependant, dans le flux qui le conduit insensiblement à la disparition, certaines zones de visibilité qui en révèlent le caractère à la fois fragile et intensif. Nous allons donc envisager certaines pratiques ou certains usages du photogramme cinématographique, tout en essayant de dégager, au départ de ces pratiques, les éléments d’une théorie du photogramme, que Roland Barthes et Sylvie Pierre appelaient déjà de leurs vœux. Des protos-photogrammes et de leur usage scientifique chez Muybridge et Marey, aux usages artistiques contemporains, en passant par des pratiques publicitaires, promotionnelles ou analytiques, nous allons voir que le photogramme reste un objet singulier. [less ▲]

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See detailDo aphids actively search for ant partners?
Fischer, Christophe ULg; Vanderplanck, Maryse; Lognay, Georges ULg et al

in Insect Science (in press)

The aphid–ant mutualistic relationships are not necessarily obligate for neither partners but evidence is that such interactions provide them strong advantages in terms of global fitness. While it is ... [more ▼]

The aphid–ant mutualistic relationships are not necessarily obligate for neither partners but evidence is that such interactions provide them strong advantages in terms of global fitness. While it is largely assumed that ants actively search for their mutualistic partners namely using volatile cues; whether winged aphids (i.e. aphids’ most mobile form) are able to select ant-frequented areas had not been investigated so far. Ant-frequented sites would indeed offer several advantages for these aphids including a lower predation pressure through ant presence and enhanced chances of establishing mutuaslistic interactions with neighbour ant colonies. In the field, aphid colonies are often observed in higher densities around ant nests, which is probably linked to a better survival ensured by ants’ services. Nevertheless, this could also result from a preferential establishment of winged aphids in ant-frequented areas. We tested this last hypothesis through different ethological assays and show that the facultative myrmecophilous black bean aphid, Aphis fabae L., does not orientate its search for a host plant preferentially towards ant-frequented plants. However our results suggest that ants reduce the number of winged aphids leaving the newly colonized plant. Thus, ants involved in facultative myrmecophilous interactions with aphids appear to contribute to structure aphid populations in the field by ensuring a better establishment and survival of newly established colonies rather than by inducing a deliberate plant selection by aphid partners based on the proximity of ant colonies. [less ▲]

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See detailOn the asymptotic standard error of a class of robust estimators of ability in dichotomous item response models
Magis, David ULg

in British Journal of Mathematical & Statistical Psychology (in press)

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods ... [more ▼]

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods were introduced to lessen the impact of such aberrant responses onto the estimation process. The computation of asymptotic (i.e., large sample) standard errors (ASE) for these robust estimators, however, has not been fully considered yet. This paper focuses on a broad class of robust ability estimators, defined by an appropriate selection of the weight function and the residual measure, for which the ASE is derived from the theory of estimating equations. The maximum likelihood (ML) and the robust estimators, together with their estimated ASE, are then compared through a simulation study. It is concluded that both the estimators and their ASE perform similarly in absence of response disturbances, while the robust estimator and its estimated ASE are less biased and outperform their ML counterparts in presence of response disturbances with large impact on the item response process. [less ▲]

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See detailSome misunderstood or unknown LaTeX tricks (XIV) and LaTeX learning curve
Merciadri, Luca ULg

in TUGboat (in press)

We will here give three tricks: i. using a personalized \overline, ii. boxing every digit of an integer, iii. using \scalebox. I will then expose my point of view about the LaTeX learning curve, and give ... [more ▼]

We will here give three tricks: i. using a personalized \overline, ii. boxing every digit of an integer, iii. using \scalebox. I will then expose my point of view about the LaTeX learning curve, and give some of the most common beginners’ mistakes. [less ▲]

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See detailDramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal
Ayora, A F; HERION, Francine ULg; ROMPEN, Eric ULg et al

in Journal of Clinical Periodontology (in press)

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these ... [more ▼]

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients. [less ▲]

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See detailA note on weighted likelihood and Jeffreys modal estimation of proficiency levels in polytomous item response models
Magis, David ULg

in Psychometrika (in press)

Warm (1989) established the equivalence between the so-called Jeffreys modal and the weighted likelihood estimators of proficiency level with some dichotomous item response models. The purpose of this ... [more ▼]

Warm (1989) established the equivalence between the so-called Jeffreys modal and the weighted likelihood estimators of proficiency level with some dichotomous item response models. The purpose of this note is to extend this result to polytomous item response models. First, a general condition is derived to ensure the perfect equivalence between these two estimators. Second, it is shown that this condition is fulfilled by two broad classes of polytomous models including, among others, the partial credit, rating scale, graded response and nominal response models. [less ▲]

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See detailGenetic parameters for mid-infrared methane indicators based on milk fatty acids in dairy cows
Kandel, Purna Bhadra ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Journal of Applied Animal Research (in press)

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not ... [more ▼]

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not currently available. The mid-infrared (MIR) prediction of milk fatty acids is relevant in this context. Five MIR methane indicators were derived from the literature and were calibrated from 600 samples analyzed by gas chromatography. Genetic parameters for these traits were estimated using single trait random regression test-day models from 619,265 records collected from 2007 to 2011 on 71,188 Holstein cows in their first three lactations. For the published indicator showing the highest relationship with the methane data (R2 = 0.88), the average daily heritability was 0.34±0.01, 0.37±0.01 and 0.34±0.01 for the first three lactations, respectively. The methane emission (g/day) was increased from beginning of lactation, reached at the highest in peak of lactation and decreased towards end of lactation. The largest differences between estimated breeding values (EBV) of sires having daughters in production eructing the highest and the lowest methane content was 21.80, 22.75 and 24.89 kg per lactation for the first three parities. Positive genetic correlations were estimated between indicator traits and milk fat and protein content. Low negative correlation was observed with milk yield. In conclusion, this study shows the feasibility to predict methane indicator traits by MIR. Moreover, the estimated genetic parameters suggest also a potential genetic variability of the quantity of methane eructed by dairy cows. [less ▲]

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See detailCost monitoring in clam farms in Coastal Nam Dinh Province of Vietnam
Bui Thi, Nga; Tran Huu, Cuong; Lebailly, Philippe ULg

in Scholars Journal of Agriculture and Veterinary Sciences (SJAVS) (in press), (Nov. 2014-Jan 2015), 2(1),

Clam farming is a strength in the agricultural development of the coastal communes in Nam Dinh province, which has developed rapidly in recent years. It has many advantages of no investment on food, low ... [more ▼]

Clam farming is a strength in the agricultural development of the coastal communes in Nam Dinh province, which has developed rapidly in recent years. It has many advantages of no investment on food, low capital in technique management, simple care, short cultured time. It could bring high profits for the farmers, create employment for labor in rural area and contribute significantly to local economy. In addition, the model of clam farming can be easily replicated so clam farming attracts a lot of attention from the coastal fishermen, policy makers and participation of scientists. However, the development of clam farming in this province is still spontaneous, without obvious planning and sustainable development strategies. In addition, market becomes more competitive. Farmers manage their farms base on experiences and depend too much on natural conditions, thus they are facing many risks. This lead to the situation of inefficiency, and affects negatively to the clam farming and environment. This research aims to study about cost monitoring in clam farms and analyze the factors affecting the cost monitoring in clam farms in Nam Dinh province. From which, suggestions to develop effectively clam farming and contribute to raise incomes for farmers were given in the next years in Nam Dinh province. [less ▲]

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See detailEstimated daily intake and cumulative risk assessment of phthalate diesters in a Belgian general population
Dewalque, Lucas ULg; Charlier, Corinne ULg; PIRARD, Catherine ULg

in Toxicology Letters (in press)

The daily intakes (DI) were estimated in a Belgian general population for 5 phthalates, namely diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), butylbenzyl phthalate ... [more ▼]

The daily intakes (DI) were estimated in a Belgian general population for 5 phthalates, namely diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), butylbenzyl phthalate (BBzP) and di-2-ethylhexyl phthalate (DEHP), based on the urinary measurements of their corresponding metabolites. DI values ranged between <LOD and 59.65 μg/kg bw/day depending on the congener, and were globally higher for children than adults. They were compared to acceptable levels of exposure (tolerable daily intakes) to evaluate the hazard quotients (HQ), which highlight an intake above the dose considered as safe for values greater than 1. If very few of our Belgian participants exceeded this threshold for phthalates considered individually, 6.2% of the adults and 25% of the children showed an excessive hazard index (HI) which took into account the cumulative risk of adverse anti-androgenic effects. These results are of concern since these HI were based on only 3 phthalates (DEHP, DiBP and DnBP), and showed a median of 0.55 and 0.29 for children and adults respectively. The comparison with previously determined dietary intakes demonstrated that for DEHP, food intake was nearly the only route of exposure while other pathways occurred mainly for the other studied phthalates. [less ▲]

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (in press)

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See detailModelling the distribution of key tree species used by lion tamarins in the Brazilian Atlantic forest under a scenario of future climate change
Raghunathan, N.; François, Louis ULg; Huynen, Marie-Claude ULg et al

in Regional Environmental Change (in press)

We used three IPCC climate change scenarios (A1B, A2 and B1) in a dynamic vegetation model (CARAIB), to determine the potential future distribution of 75 tree species used by two endemic primate species ... [more ▼]

We used three IPCC climate change scenarios (A1B, A2 and B1) in a dynamic vegetation model (CARAIB), to determine the potential future distribution of 75 tree species used by two endemic primate species from the Brazilian Atlantic Forest (BAF). Habitat conservation is a vital part of strategies to protect endangered species, and this is a new approach to understanding how key plant species needed for survival of golden lion tamarins (Leontopithecus rosalia) and golden-headed lion tamarins (L. chrysomelas) might be affected by climate change and what changes to their distribution are likely. The model accurately predicted the current distribution of BAF vegetation types, for 66 % of the individual tree species with 70 % agreement obtained for presence. In the simulation experiments for the future, 72 out of 75 tree species maintained more than 95 % of their original distribution and all species showed a range expansion. At the biome level, we note a substantial decrease in the sub-tropical forest area. There is some fragmentation of the savannah, which is encroached mostly by tropical seasonal forest. Where the current distribution shows a large sub-tropical forest biome, it has been replaced or encroached by tropical rainforest. The results suggested that the trees may benefit from an increase in temperature, if and only if soil water availability is not altered significantly, as was the case with climate simulations that were used. However, these results must be coupled with other information to maximise usefulness to conservation since BAF is already highly fragmented and subject to high anthropic pressure. © 2014 Springer-Verlag Berlin Heidelberg. [less ▲]

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See detailPérils de la copie : les cas de l’Estoire del Saint Graal, du Merlin et de la Suite Vulgate
Combes, Annie ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailRugose corals across the Devonian-Carboniferous boundary in NW Turkey
Denayer, Julien ULg

in Acta Palaeontologica Polonica (in press)

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See detailReduced Order Analysis of Aeroelastic Systems with Freeplay using an Augmented Modal Basis
Silva, Gustavo H. C.; Dal Ben Rossetto, Gustavo; Dimitriadis, Grigorios ULg

in Journal of Aircraft (in press)

Freeplay in aircraft control surface actuators is a common source of nonlinearity that can cause undesirable aeroelastic phenomena and, as a consequence, certification authorities place strict limits on ... [more ▼]

Freeplay in aircraft control surface actuators is a common source of nonlinearity that can cause undesirable aeroelastic phenomena and, as a consequence, certification authorities place strict limits on the size of the deadband gaps of actuators. In recent years many authors have worked on determining the effects of freeplay on the dynamic behavior of aeroelastic systems; these efforts have yielded significant improvements in the understanding of the phenomena, but have concentrated on simple models. Investigations of industry-relevant aeroelastic models of complete aircraft with freeplay in the actuators have been much rarer, the main difficulty being the selection of an appropriate modal basis that can represent the full range of possible dynamic phenomena. This work presents a novel implementation of the residual vectors approach to create consistent and numerically stable reduced order models suitable for industrial-standard aeroelastic models of aircraft. The methodology relies on the piecewise linear nature of freeplay to create a single reduction basis that represents the dynamics of the system both inside and outside the freeplay deadband gap. The method is demonstrated on an Embraer generic test bench aircraft, showing that the resulting reduced order model is efficient and effective. Nonlinear analysis is carried out using equivalent linearization as well as time integrations of the full nonlinear system. It is shown that, while equivalent linearization is an indispensable tool for a preliminary mapping of the main aeroelastic instabilities, the time integration-based nonlinear analysis is an essential complementary tool to confirm the characteristics of the system behavior. [less ▲]

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See detailSens et signification dans l'esthétique de Mallarmé
Durand, Pascal ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press), 5

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See detailOrigin and immunoescape of uterine cervical cancer
Van hede, Dorien ULg; Langers, Inge ULg; DELVENNE, Philippe ULg et al

in Presse Médicale (in press)

Human papillomavirus associated uterine cervical cancer is an important public health problem since it is classified as the fourth most common cancer in women worldwide with more than 500 000 recorded ... [more ▼]

Human papillomavirus associated uterine cervical cancer is an important public health problem since it is classified as the fourth most common cancer in women worldwide with more than 500 000 recorded cases. This review is focused on where and why HPV infection induces cervical cancers and how this virus avoids the host immune response. Immunological therapeutic approaches are also addressed. [less ▲]

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See detailCorporate Disclosures, Information Asymmetry and Stock-Market Liquidity in France
Sougné, Danielle ULg; Ajina, Aymen; Lakhal, Faten

in Journal of Applied Business Research (in press)

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of ... [more ▼]

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of information included in the annual reports on investor’s behavior. This is proxied by the information asymmetry component of the bid-ask spread and stock market liquidity. Our sample includes 196 French listed firms over a period ranging from 2004 to 2007. We opt for an explanatory study using OLS regressions to examine the nature of the relationship between information disclosed in annual reports and bid-ask spreads a proxy for information asymmetry and stock market liquidity. The results show that the extent of corporate disclosures in annual reports positively influences the liquidity of the French market and negatively affects the adverse selection component of the bid-ask spread. This effect is further confirmed by the commitment to IFRS by French-listed firms from 2005. The decomposition of the total score in the sub-indices shows that non-financial and financial information are important in trading decisions while strategic information may be attractive only for long-term positions [less ▲]

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See detailEvaluation of the impact of 6-month training by whole body vibration on the risk of falls among nursing home residents, observed over a 12-month period: a single blind, randomized controlled trial.
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Maquet, Didier ULg et al

in Aging Clinical & Experimental Research (in press)

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement ... [more ▼]

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement of motor capacity were observed. OBJECTIVE: The objective of the present study was to evaluate the impact of 6-month training by WBV on functional and motor abilities among nursing home residents observed over a 12-month period. METHODS: Patients were randomized into two groups: the WBV group which received three training sessions every week composed of five series of 15 s of vibration at 30 Hz intensity for a period of 6 months and a control group with normal daily life. The impact of this training on the risk of falls was assessed blindly after 6 and 12 months by the Tinetti Test, the "Timed Up and Go" test and a quantitative evaluation of a 10-s walk performed with a tri-axial accelerometer. The occurrence of falls was also observed. RESULTS: 62 elderly healthy volunteers, (47 women and 15 men, mean age 83.2 +/- 7.9 years) were included in this study. There was no significant difference between the two groups regarding the Tinetti test (p = 0.75), the "Timed Up and Go" test (p = 0.19) and the Locometrix(R) test, except for the step length, measured by dual task (p < 0.01). No significant inter-group difference in the frequency of falls was observed during the 12 months of research. A total of 42 falls were recorded during the first 6 months of experimentation: 24 falls in the treated group and 18 in the control group (p = 0.60). During the next 6 months, 19 falls occurred: 8 falls in the treated group and 11 in the control group (p = 0.52). CONCLUSION: This study failed to establish the effectiveness of low doses of WBV, under the conditions used in our study, on functional and motor abilities of institutionalized elderly patients. However, given the positive results of other studies, further investigations, with modified therapeutic protocols, seem necessary to clarify the effects of WBV in the elderly. [less ▲]

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See detailDépister la fragilité, un bénéfice pour le patient et pour le soignant
RICOUR, Céline ULg; DESAINTHUBERT, Marie; GILLAIN, Sophie ULg et al

in Revue Médicale de Liège (in press)

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See detailNégocier une majorité politique et devenir bourgmestre en Belgique. Quelles influences des droits régionaux ?
Grandjean, Geoffrey ULg

in Revue Régionale de Droit [= RRD] (in press)

Depuis 2001, les Régions sont compétentes en matière d’organisation et d’élection des pouvoirs locaux. Elles ont adopté des règles différentes. Dans quelle mesure ces règles influencent-elles la ... [more ▼]

Depuis 2001, les Régions sont compétentes en matière d’organisation et d’élection des pouvoirs locaux. Elles ont adopté des règles différentes. Dans quelle mesure ces règles influencent-elles la négociation d’une majorité politique et la désignation des bourgmestres en Belgique ? Afin de répondre à cette question, des entretiens semi-directifs ont été réalisés avec plusieurs bourgmestres et échevin issus de communes localisées dans les trois Régions. Des différences entre Régions mais également au sein de celles-ci ont été relevées. Les dispositions relatives au mode de désignation du bourgmestre sont primordiales pour comprendre les dynamiques de négociations politiques. Au final, cet article tisse les liens entre les normes juridiques et les jeux des acteurs politiques. [less ▲]

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See detailLes défis colossaux auxquels la santé publique va devoir faire face !
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (in press)

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See detailInternal encoding style and schizotypy: towards a conceptually-driven account of positive symptoms
Belayachi, Sanaa ULg; Laloyaux, Julien ULg; Laroi, Frank ULg et al

in Journal of Personality Disorders (in press)

Perception results from a combination of actual data and interpretative schemata based on pre-existing knowledge. Thus, ensuing subjective experience depends on the dynamic interplay between data-driven ... [more ▼]

Perception results from a combination of actual data and interpretative schemata based on pre-existing knowledge. Thus, ensuing subjective experience depends on the dynamic interplay between data-driven and conceptually-driven processing. A chronic imbalance between these two sources of stimulus encoding is likely to be maladaptive and could underlie cognitive and behavioral disturbances similar to that observed in schizotypy, especially if the balance is tipped too far towards conceptually-driven processing (i.e., Internal encoding style). This study aimed to examine the relationships between encoding style and various dimensions of schizotypy, by using a questionnaire that evaluates the extent to which pre-existing schemata (versus cues from the outside world) affect encoding processes. Consistent with previous findings, our results revealed that both Cognitive-Perceptual and Disorganization dimensions were related to an internal mode of encoding, suggesting that individuals with these features may be characterized by a disposition to biases at early stages of encoding. [less ▲]

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See detailRelevance of accelerated conditions for the study of monoethanolamine degradation in post-combustion CO2 capture.
Léonard, Grégoire ULg; Toye, Dominique ULg; Heyen, Georges ULg

in Canadian Journal of Chemical Engineering (in press)

Solvent degradation represents one of the main operational drawbacks of the post-combustion CO2 capture process. Degradation not only induces additional costs for solvent make-up, it also impacts the ... [more ▼]

Solvent degradation represents one of the main operational drawbacks of the post-combustion CO2 capture process. Degradation not only induces additional costs for solvent make-up, it also impacts the process efficiency and its environmental penalty due to the emission of various degradation products. There is still a gap of knowledge about the influence of process operating conditions on degradation, making it currently impossible to predict the solvent degradation rate in CO2 capture plants. Morever, the reaction mechanisms corresponding to solvent degradation are very slow, significantly complicating its study in industrial units. In the present work, appropriate experimental equipment and analytical methods are developed for accelerating the degradation of monoethanolamine solvents (MEA). The relevance of accelerated conditions is established by comparing artificially degraded solvent samples with degraded solvent samples from industrial CO2 capture pilot plants. Two approaches are evaluated implying either discontinuous or continuous gas feed, this latest being the most representative of industrial degradation. The respective influences of the gas feed composition and the gas-liquid transfer are evidenced and quantified. Finally, the present study leads to a better understanding of solvent degradation in the CO2 capture process with MEA. More generally, it also evidences that accelerated conditions at laboratory-scale may provide relevant information for the study of slow phenomena taking place in large-scale industrial processes. Further works include the development of a kinetic model for MEA solvent degradation and the extension of this methodology to other promising solvents in order to facilitate the operation and large-scale deployment of CO2 capture. [less ▲]

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See detailComposantes métacognitives ; Définitions et outils d’évaluation
Frenkel, Stéphanie ULg

in Enfance : Psychologie, Pédagogie, Neuropsychiatrie, Sociologie (in press)

Many tools have been developed since the 1970s in order to assess metacognition and its first implementations. Over time, questionnaires, tests, interviews, observations, computer programmes, and other ... [more ▼]

Many tools have been developed since the 1970s in order to assess metacognition and its first implementations. Over time, questionnaires, tests, interviews, observations, computer programmes, and other methods have become more and more based on self-regulated learning theories. At the same time, for the last fifteen years or so, the number of students with learning difficulties linked to the way they learn seems to be increasing slowly but steadily. Therefore, it seems essential to enable these learners develop a more efficient learning behaviour. Similarly, we see that professional field workers are increasingly asking for efficient and adapted tools in this field. The purpose of this paper is twofold: it provides a review of the above-mentioned assessment tools, and it discusses them in order to contribute to the creation of new tools with a wider scope. Following an analysis of the abundant literature on the subject, two classifications were developed. Thirty-five tools were kept and categorised: first, according to a developmental perspective (preschool, primary school, secondary school and/or adult), second, according to the metacognitive component they assess (metacognitive knowledge, strategies and/or experiences). However, no existing tool covers the whole period of compulsory education. Moreover, in order to assess the learners’ metacognitive abilities fully, it is necessary to combine online and offline assessments in concrete situations. There are still some needs to be met in this regard. [less ▲]

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See detailFernand De Visscher et la Société Internationale d'Histoire des Droits de l'Antiquité
Gerkens, Jean-François ULg

in Revue Historique de Droit Français et Etranger [=RHD] (in press)

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See detailSinging ability is rooted in vocal-motor control of pitch
Hutchins, Sean; Larrouy, Pauline ULg; Peretz, Isabelle

in Attention, Perception & Psychophysics (in press)

The inability to vocally match a pitch can be caused by poor pitch perception or by poor vocal-motor control. Although previous studies have tried to examine the relationship between pitch perception and ... [more ▼]

The inability to vocally match a pitch can be caused by poor pitch perception or by poor vocal-motor control. Although previous studies have tried to examine the relationship between pitch perception and vocal production, they have failed to control for the timbre of the target to be matched. In the present study, we compare pitch matching accuracy with an unfamiliar instrument (the slider) and with the voice, designed such that the slider plays back recordings of the participant’s own voice. We also measured pitch accuracy in singing a familiar melody (“Happy Birthday”) to assess the relationship between single pitch matching tasks and melodic singing. Our results showed that participants (all nonmusicians) were significantly better at matching recordings of their own voices with the slider than with their voice, indicating that vocal-motor control is an important limiting factor on singing ability. We also found significant correlations between the ability to sing a melody in tune and vocal pitch matching, but not instrumental pitch matching. Better melodic singers also tended to have higher quality voices (as measured by acoustic variables). These results provide important evidence about the ultimate causes of poor singing ability, and demonstrate that single pitch matching tasks can be useful in measuring general singing abilities. [less ▲]

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (in press)

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailÀ propos de deux pièges en psychopathologie
Englebert, Jérôme ULg

in Le Cercle Herméneutique (in press), 22

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See detailMartin Heidegger, Extrait du dernier cours de Marbourg
Pieron, Julien ULg

in Philosophie (in press)

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See detailBreed-specific hematologic reference intervals in healthy adult Dogue de Bordeaux dogs
Lavoué, Rachel; Geffré, A; Braun, JP et al

in Veterinary Clinical Pathology (in press)

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See detailClinical pattern characterisation of cattle naturally infected by BTV-8 - Clinical characterisation of BTV-8 infected cattle
Zanella, G; Martinelle, Ludovic ULg; Guyot, Hugues ULg et al

in Transboundary and Emerging Diseases (in press)

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See detailNatural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.
Langers, Inge ULg; Renoux, Virginie; Reschner, Anca et al

in European journal of immunology (in press)

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since ... [more ▼]

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since NK cells collaborate with dendritic cells (DCs) to induce an immune response against viral infections and tumors, we studied the impact of this crosstalk in the context of HPV vaccination. NK cells in the presence of HPV-VLPs enhanced DC maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10. This activation was bi-directional. Indeed, in the presence of HPV-VLPs, DCs further activated NK cells by inducing the upregulation of cell surface activation markers (CD69 and HLA-DR). The function of NK cells was also improved as shown by an increase in IFN-gamma secretion and cytotoxic activity against an HPV+ cell line. This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated. Our results provide insight into how VLPs interact with innate immune cells and how NK cells and DCs play a role in the immune response induced by this vaccine agent. This article is protected by copyright. All rights reserved. [less ▲]

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See detailA generic anisotropic continuum damage model integration scheme adaptable to both ductile damage and biological damage-like situations
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (in press)

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations ... [more ▼]

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations. For this purpose a staggered time integration scheme in a finite strain framework is presented, together with an analytical consistent tangent operator. The only restrictive hypothesis is to work with an undamaged isotropic material, assumed here to follow a J2 plasticity model. The only anisotropy considered is thus a damage-induced anisotropy. The possibility to couple any damage rate law with the present algorithm is illustrated with a classical ductile damage model for aluminium, and a biological damage-like application. The later proposes an original bone remodelling law coupled to trabecular bone plasticity for the simulation of orthodontic tooth movements. All the developments have been considered in the framework of the implicit non-linear finite element code Metafor (developed at the LTAS/MN2L, University of Liège, Belgium - www.metafor.ltas.ulg.ac.be). [less ▲]

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See detailSome misunderstood or unknown tricks (X) (LaTeX)
Merciadri, Luca ULg

in TUGboat (in press)

This is the 10th edition of my TUGboat `Tips & Tricks.' This time, we shall first see how to write `dancing text,' roman numerals, how to draw under and over braces on same elements, and how to display ... [more ▼]

This is the 10th edition of my TUGboat `Tips & Tricks.' This time, we shall first see how to write `dancing text,' roman numerals, how to draw under and over braces on same elements, and how to display aligned (in)equations systems. We will then end by discussing on BibLaTeX and Biber, which constitute a promising alternative to BibTeX. [less ▲]

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See detailExperimental and numerical study of the flight of geese
Dimitriadis, Grigorios ULg; Gardiner, James; Tickle, Peter et al

in Aeronautical Journal (in press)

The flight of barnacle geese at airspeeds representing high-speed migrating flight is investigated using experiments and simulations. The experimental part of the work involved the filming of three ... [more ▼]

The flight of barnacle geese at airspeeds representing high-speed migrating flight is investigated using experiments and simulations. The experimental part of the work involved the filming of three barnacle geese (Branta Leucopsis) flying at different airspeeds in a wind tunnel. The video footage was analysed in order to extract the wing kinematics. Additional information, such as wing geometry and camber was obtained from a 3D scan of a dried wing. An unsteady vortex lattice method was used to simulate the aerodynamics of the measured flapping motion. The simulations were used in order to successfully reproduce the measured body motion and thus obtain estimates of the aerodynamic forces acting on the wings. It was found that the mean of the wing pitch angle variation with time has the most significant effect on lift while the difference in the durations of the upstroke and downstroke has the major effect on thrust. The power consumed by the aerodynamic forces was also estimated; it was found that increases in aerodynamic power correspond very closely to climbing motion and vice versa. Root-mean-square values of the power range from 100 W to 240 W. Finally, it was observed that tandem flying can be very expensive for the trailing bird. [less ▲]

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See detailAtomistic account of structural and dynamical changes induced by small binders in the double helix of a short DNA
Fresch, Barbara ULg; Remacle, Françoise ULg

in Physical Chemistry Chemical Physics [=PCCP] (in press)

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See detailCalibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Cristol, Jean-Paul et al

in Journal of Nephrology (in press)

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay ... [more ▼]

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results (‘compensated Jaffe method’). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR[60 ml/ min/1.73 m2). Analytical limitations have led to the recommendation to give a grade ([60 ml/min/1.73 m2) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m2 (with MDRD) and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund– Malmo¨ (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated. [less ▲]

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See detailInfluence of Homogenization Treatment on Physicochemical 4 Properties and Enzymatic Hydrolysis Rate of Pure 5 Cellulose Fibers
Jacquet, Nicolas ULg; Vanderghem, Caroline ULg; Danthine, Sabine ULg et al

in Applied Biochemistry and Biotechnology (in press)

The aim of this study is to compare the effect of different homogenization treat- 12 ments on the physicochemical properties and the hydrolysis rate of a pure bleached 13 cellulose. Results obtained show ... [more ▼]

The aim of this study is to compare the effect of different homogenization treat- 12 ments on the physicochemical properties and the hydrolysis rate of a pure bleached 13 cellulose. Results obtained show that homogenization treatments improve the enzymatic 14 hydrolysis rate of the cellulose fibers by 25 to 100 %, depending of the homogenization 15 treatment applied. Characterization of the samples showed also that homogenization had an 16 impact on some physicochemical properties of the cellulose. For moderate treatment inten- 17 sities (pressure below 500 b and degree of homogenization below 25), an increase of water 18 retention values (WRV) that correlated to the increase of the hydrolysis rate was highlighted. 19 Result also showed that the overall crystallinity of the cellulose properties appeared not to be 20 impacted by the homogenization treatment. For higher treatment intensities, homogenized 21 cellulose samples developed a stable tridimentional network that contributes to decrease 22 cellulase mobility and slowdown the hydrolysis process. [less ▲]

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See detailClimate-controlled palynofacies and miospore biostratigraphy of the Early Devonian Jauf Formation, northern Saudi Arabia
Breuer, Pierre; Leszczynski, S.; Miller, M.A. et al

in Review of Palaeobotany and Palynology (in press)

The Jauf Formation miospore succession is synthesized in terms of paleoenvironments and sequence stratigraphy. The data set for this study is obtained from four overlapping, continuously cored, and ... [more ▼]

The Jauf Formation miospore succession is synthesized in terms of paleoenvironments and sequence stratigraphy. The data set for this study is obtained from four overlapping, continuously cored, and extensively sampled, boreholes that for a 940 ft composite section. The Jauf Formation ranges in age from late Pragian to latest Emsian. The palynological assemblages, recognized herein, provide the basis for recognizing depositional environments present in the Early Devonian of northern Saudi Arabia. Transgressive – regressive cycles are indicated, not only by lithology but by marked changes in the marine to terrestrially dominated palynological assemblages. Flooding events are recognized by the replacement of spore dominated assemblages by organic-walled microphytoplankton. The maximum flooding interval for the Jauf is reinterpreted based on a correlative event consisting of diverse acritarchs and abundant chitinozoans. [Add details on the paly and sequence stratigraphy here. No.cycles and order.] The new northern Gondwanan biozonation developed by Breuer and Steemans (2012) and used here allows a high-resolution regional biozonation for the Arabian Plate and more intercontinental [?] correlation of the Jauf Formation with other Gondwanan and Euramerican localities. One new spore genus (Zonohilates) and four spore species (Insculptospora maxima, Camarozonotriletes alruwailii, Devonomonoletes crassus and Zonohilates vulneratus) are newly proposed. [less ▲]

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See detailHydroxymethylfurfural: a possible emergent cause of honey bee mortality?
Zirbes, Lara ULg; Nguyen, Bach Kim ULg; de Graaf, DC et al

in Journal of Agricultural and Food Chemistry (in press)

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See detailScience et Dynastie en Belgique : les "conseillers scientifiques" du Roi sous Albert Ier et Léopold III
Pirot, Pascal ULg

in Mosaïque, revue de jeunes chercheurs en SHS – Lille Nord de France – Belgique (in press)

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See detailA.P.M.H. Lardinois, J.H Blok et M.G.M. Van der Poel, Sacred Words: Orality, Literacy and Religion, Leiden-Boston, Brill, 2011
Delli Pizzi, Aurian ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (in press)

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See detaileffects of cholecaciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone haelth: a one-year pilot randomized controlled trial in adults with severe burns
ROUSSEAU, Anne-Françoise ULg; FOIDART-DESSALLE, Marguerite ULg; LEDOUX, Didier ULg et al

in Burns : Journal of the International Society for Burn Injuries (in press)

Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess ... [more ▼]

Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury. Design: Monocentric randomized controlled trial. Methods: Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups. For 12 months, they either received a quarterly IM injection of 200,000 IU VD3 and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers were assessed every 3 months. Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol. Results: Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40 y) were considered osteopenic at inclusion. After one year, calcidiol levels significantly increased in Group D to reach 40 (37–61) ng/ml. No significant change in bone health was observed in both groups while Group D significantly improved quadriceps strength when tested at high velocity. Conclusions: This VD3 supplementation was safe and efficient to correct hypovitaminosis D in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects on muscle health but not on bone health. A high prevalence of hypovitaminosis D and osteopenia in these patients, as well as their wide range of muscle performances, seem to be worrying when considering rehabilitation and quality of life. [less ▲]

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