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See detailPatterns of metal distribution in hypersaline microbialites during early diagenesis: Implications for the fossil record
Sforna, Marie-Catherine ULg; Daye, Mirna; Philippot, Pascal et al

in Geobiology (in press)

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See detailLe phénotype d’Akhenaton ; revue critique entre canons artistiques et expression pathologique.
JEDIDI, Zayd ULg; JEDIDI, Haroun ULg; LAVEAUX, Elisabeth ULg et al

in Revue Médicale de Liège (in press)

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 ... [more ▼]

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 years after their time. Tenth pharaoh of this dynasty and father of Tutankhamun, Akhenaten (Amenhotep/Amenhotep IV) still fascinates Egyptologists and history lovers through the many questions surrounding his atypical rule. One of the most striking aspects of the so-called Amarna period concerns the representations of the pharaoh himself, very confusing compared to the traditional iconography of the New Kingdom. These intriguing portraits of Pharaoh raised a whole lot of medical assumptions, more or less substantiated. We review here the main theories developed throughout history. [less ▲]

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See detailEffect of feed enzymes on digestibility and growth in weaned pigs: A systematic review and meta-analysis
Torres-Pitarch, Alberto; Hermans, David; Manzanilla, Edgar Garcia et al

in Animal Feed Science & Technology (in press)

Supplementation of post-weaning diets with exogenous enzymes has been suggested to control post-weaning syndrome, by compensating for the under-developed endogenous enzyme secretory capacity and ... [more ▼]

Supplementation of post-weaning diets with exogenous enzymes has been suggested to control post-weaning syndrome, by compensating for the under-developed endogenous enzyme secretory capacity and increasing nutrient digestibility in newly weaned pigs. The effect of in-feed enzymes in improving gut maturation, growth and/or health in weaned piglets is not always consistent. A systematic review and a meta-analysis were therefore conducted to determine which exogenous enzymes are most consistent in improving piglet growth and digestibility when supplemented to post-weaning diets. The mean difference effect of enzyme supplementation on growth and digestibility of dry matter (DM), gross energy (GE), crude protein (CP), and P digestibility was calculated for each study and this was used as the effect size estimate in the meta-analysis. The impact of feed enzyme supplementation on intestinal health and bone mineralization was also discussed where information was available in the literature. From a total of 90 studies included in the metaanalysis, G:F was improved in 55, remained un-changed in 28 and deteriorated in 7, in response to enzyme supplementation. Average daily gain, average daily feed intake (ADFI) and G:F was improved when phytase was supplemented in the diet. Phosphorous digestibility was increased with phytase supplementation while GE digestibility was reduced. Dietary phytase supplementation increased bone mineralization in pigs fed diets with a reduced Pcontent. Supplementation with multi-enzyme complexes increased DM and CP digestibility. In conclusion, the most consistent improvement in piglet growth, P digestibility and bone mineralization were found due to exogenous phytase supplementation. Supplementation with xylanase alone or in combination with β-glucanase had inconsistent effects on piglet growth and nutrient digestibility. The most consistent improvements in growth and nutrient digestibility due to supplementation with multi-enzymes complexes were found when mannanase and/or protease were included in the complex. [less ▲]

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See detailIgnorance et maîtrise de la bête. Lefort critique de l'éducation "humaniste".
Mancuso, Eva ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailMicrobiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015)
Filippitzi, ME; Goumperis, T; Robinson, T et al

in Transboundary and emerging diseases (in press)

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See detailInnovative polyelectrolytes/poly(ionic liquid)s for energy and environment
Ajjan, Fátima N.; Ambrogi, Martina; Tiruye, Girum Ayalneh et al

in Polymer International (in press)

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications ... [more ▼]

This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications. Within the project different types of innovative polyelectrolytes were synthesized such as poly(ionic liquid)s coming from renewable or natural ions, thiazolium cations, cathechol functionalities or from a new generation of cheap deep-eutectic monomers. Further, macromolecular architectures such as new poly(ionic liquid) block copolymers and new (semi)conducting polymer/polyelectrolyte complexes were also developed. As the final goal, the application of these innovative polymers in energy and environment was investigated. Important advances in energy storage technologies included the development of new carbonaceous materials, new lignin/conducting polymer biopolymer electrodes, new iongels and single-ion conducting polymer electrolytes for supercapacitors and batteries and new poly(ionic liquid) binders for batteries. On the other hand, the use of the innovative polyelectrolytes into sustainable environmental technologies led to the development of new liquid and dry water, new materials for water cleaning technologies such as floculants, oil absorbers, new recyclable organocatalysts platform and multifunctional polymer coatings with antifouling and antimicrobial properties. All in all this article demonstrates the potential of the poly(ionic liquid)s for high-value applications in Energy & Enviromental areas. [less ▲]

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See detailEffect of different parameters on composition of volatile components of Myristica fragrans seeds extracted by hydrodistillation assisted by microwave and head-space solid-phase microextraction
Bouchachia, C; Benkaci-Ali, F; Eppe, Gauthier ULg et al

in Journal of Essential Oil Research (in press)

Hydrodistillation assisted by microwave (HDAM) and Head space solid phase micro-extraction (HSSPME) of Myristica fragrans houtt (MF) were investigated. A kinetic study was performed for MF seeds using two ... [more ▼]

Hydrodistillation assisted by microwave (HDAM) and Head space solid phase micro-extraction (HSSPME) of Myristica fragrans houtt (MF) were investigated. A kinetic study was performed for MF seeds using two techniques (HDAM: Hydrodistillation assisted by microwave and SDAM: steam distillation assisted by microwave). The effect of the cryogenic grinding (CG) showed differences in yields and composition of volatile oils compared to the simple grinding (SG). HDAM–SG (3.4%) and SDAM–SG (2.55%) allowed extraction of substantial amounts of volatile oils in less time compared with HDAM–CG (4.75%) and SDAM–CG (3.8%). The kinetic study (differential and accumulated yields) of essential oil extraction was quantitatively and qualitatively performed showing a significant variation of composition with the extraction time, especially for accumulated yields such as sabinene (31.48–38.78%), α-pinene (12.74–14.09%) and β-pinene (10.01–12.11%). Similarly, the HS-SPME–GC–MS analysis showed also a significant variation of MF seeds volatile composition according some parameters as the type of fibre coating (PDMS: Polydimethylsiloxane and PDMS– DVB: Polydimethylsiloxane divenylbenzene), particle size, grinding mode and the mass used. The chemical groups (monoterpenoids, aliphatic and aromatic alcohols and esters) showed specific behaviour in SPME analysis. SPME sampling parameters were optimized for these components. [less ▲]

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See detailEvaluation of different hydrocolloids to improve dough rheological properties and bread quality of potato-wheat flour
Liu, Xingli ULg; Mu, Taihua; Yamul, Karim Diego et al

in Journal of Industrial and Engineering Chemistry (in press)

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato ... [more ▼]

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato-wheat dough (the mass ratio was 1:1) rheological, fermentation properties and its bread quality. The tan δ of potato-wheat dough was significantly increased by adding HPMC compared to those of without adding hydrocolloids (from 0.337 to 0.425), which was close to wheat dough (0.531). Moreover, the dough height during fermentation process was significantly improved by adding hydrocolloids, with the order of HPMC (23.1mm) > AP (19.3mm) > AG (18.6mm) > KG (13.6mm). In addition, the potato-wheat protein bands of potato-wheat dough turned pale by adding hydrocolloids, suggesting higher molecular weight aggregation formed between proteins-hydrocolloids or proteins-proteins after fermentation process. Furthermore, HPMC significantly increased specific volume (from 1.45 to 2.22 ml/g), and hydrocolloids restrained the starch retrogradation of potato-wheat breads. [less ▲]

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See detailPilgrimage Certificates from the Mamluk Period: New Data
Bauden, Frédéric ULg

in Bulletin of the School of Oriental and African Studies (in press)

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See detailChronique du colloque international "Médecine et christianisme : sources et pratiques" (Paris, 15-16 septembre 2016)
Carlig, Nathan ULg

in Lettre d'informations du Centre Jean Palerne (in press)

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULg; Pieron, Julien ULg

in Dissensus (in press)

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See detailNew insights on the Picasso’s Blue Period painting La famille Soler through non-invasive imaging and analytical techniques
Defeyt, Catherine ULg; Walter, Philippe; Rousselière, Hélène et al

in Studies in Conservation (in press)

The material study of La Famille Soler through non-invasive imaging, molecular, structural and elemental techniques, permitted a relevant re-examination of this singular blue period painting, which is ... [more ▼]

The material study of La Famille Soler through non-invasive imaging, molecular, structural and elemental techniques, permitted a relevant re-examination of this singular blue period painting, which is considered as the earliest Picasso’s version of Le déjeuner sur l’herbe by E. Manet. On the one hand, it was concluded that the underlying landscape painted by Vidal in 1903 referred to Manet’s masterpiece. On the other hand, it was assumed that the cubist sketch undertaken by Picasso in 1912, prior to the current blue background, consists of an uncompleted transformation of Vidal’s landscape into synthetic cubism. Additionally, the main pigments associated to the underlying compositions were successfully identified. [less ▲]

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See detailLa traduction dans le domaine hagiographique médiolatin : l’apport de la linguistique quantitative
Philippart de Foy, Caroline ULg

in Rursus (in press), 9

Au fil des siècles, le corpus latin des vitae sanctorum et des passiones martyrum s’est enrichi par l’introduction de nouveaux textes, par la réécriture et l’adaptation d’anciens remis au goût du jour ... [more ▼]

Au fil des siècles, le corpus latin des vitae sanctorum et des passiones martyrum s’est enrichi par l’introduction de nouveaux textes, par la réécriture et l’adaptation d’anciens remis au goût du jour, ainsi que par la traduction d’oeuvres issues du monde byzantin. Le phénomène de la réécriture hagiographique est bien connu et a fait l’objet de nombreux travaux. Celui de la traduction dans ce domaine reste en revanche peu exploité, tant il existe d’obstacles à son étude (absence de répertoire, manque d’éditions critiques, difficultés à identifier les traductions et les modèles grecs, etc.). Le présent travail propose une approche originale du phénomène, basée sur l’utilisation de la statistique linguistique. Cette approche consiste à étudier le latin utilisé par les traducteurs hagiographes pour rendre leur modèle grec et les techniques qu’ils ont adoptées pour le traduire en considérant les traductions non pas une à une, mais d’une manière comparative au moyen de l’analyse quantitative, dans le but de caractériser et de classer les traductions sur base de critères linguistiques, d’identifier et de qualifier des pratiques, des traditions localisées, des spécificités d’école ou de traducteur. La pratique de la traduction est examinée à travers un corpus de 35 textes représentatif des différentes phases de l’histoire de la traduction hagiographique latine au Moyen Âge et des différents foyers de traduction en Italie. Les analyses sont menées sur divers paramètres lexicaux et syntaxiques, en comparant d’abord le corpus, pris dans son ensemble, à un corpus de textes non traduits, puis en comparant entre eux les différents sous-corpus de traductions. Le premier type de comparaison (externe) a pour objectif de mettre en évidence les caractéristiques des traductions en général, le second (interne) de dégager les spécificités de chaque groupe de traductions. [less ▲]

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See detailInvestigation on Water Productivity of Winter Wheat Based on MODIS and SEBAL in the Huang-Huai-Hai Plain, China
Yang, Jian-ying; HUO, Zhi-guo; Wu, Ding-rong et al

in Chinese Journal of Agrometeorology (in press)

Understanding how the productivity of water can be increased is widely accepted to be a high priority where water resources are currently scarce and/or over-exploited in China. As the primary data source ... [more ▼]

Understanding how the productivity of water can be increased is widely accepted to be a high priority where water resources are currently scarce and/or over-exploited in China. As the primary data source, MODIS remote sensing, statistics, meteorological data, crop growth period data and ground truth-data from Jan. 2011 to Dec. 2012 were used in actual evapotranspiration estimation, yields rasterizing, and water productivity calculation for winter wheat in the Huang-Huai-Hai Plain (3H Plain). The statistical data were synthesized to calculate district-state-level land productivity, which is then further extrapolated to pixel-level values using a MODIS NDVI image, based on a crop dominance map. Spatial variation of crop water productivity was investigated in order to reveal the key factors of crop water productivity. In addition, the relationship between water productivity and actual evapotranspiration and in subsequence yield for winter wheat was discussed in 3H Plain. The main results indicated that the SEBAL is suitable for estimating evapotranspiration in winter wheat based on the comparation between evapotranspiration measured by Yucheng (in Shandong province). The regional average value of water productivity for winter wheat was detected to be 1.21kg·m-3, with the higher value in Beijing, Tianjin, north part of Shandong province and south part of Hebei province. The pronounced relationship of spatial correlation of the yield and water productivity for winter wheat indicated that the increasing yield governed the increment of water productivity for winter wheat in the coastal land-farming-fishing area (zone1), low plain-hydropenia irrigable land and dry land zone (zone2) and basin- irrigable land and dry land (zone5). The increasing water productivity for winter wheat was recognized to be controlled by rather the increment of yield than the reduction of actual evapotranspiration for winter wheat in the piedmont plain-irrigable land (zone2). Whereas, the pronounced relationship of negative correlation of water productivity and actual evapotranspiration for winter wheat described that only the reduction of actual evapotranspiration was responsible for the increment of water productivity for winter wheat in hill-wet hot paddy-paddy field (zone6). The results is expected to provide a basis information for agricultural water management, improvement of crop water productivity and choice of adaptive mechanism under climate change in Huang-Huai-Hai plain. [less ▲]

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See detailOrganometallic-mediated alternating radical copolymerization of tert-butyl-2- trifluoromethacrylate with vinyl acetate and synthesis of block copolymers thereof
Banerjee, Sanjib; Ladmiral, Vincent; Debuigne, Antoine ULg et al

in Macromolecular Rapid Communications (in press)

Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE ... [more ▼]

Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE) copolymers composed of two electronically distinct monomers: vinyl acetate (VAc, donor, D) and tert-butyl-2-trifluoromethacrylate (MAF-TBE, acceptor, A), with low dispersity (≤1.24) and molar masses up to 57 000 g mol−1. These copolymers have a precise 1:1 alternating structure over a wide range of comonomer feed compositions. The reactivity ratios are determined as rVAc = 0.01 ± 0.01 and rMAF-TBE = 0 at 40 °C. Remarkably, from a feed containing >50% molar VAc content, poly(VAc-alt-MAF-TBE)-b- PVAc block copolymers are produced via a one- pot synthesis. Such diblock copolymers exhibit two glass transition temperatures attributed to the alternating and homopolymer sequences. The OMRP of this fluorine-containing alter- nating monomer system may provide access to a wide range of new polymer materials. [less ▲]

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See detailAverage first-passage time of a quasi-Hamiltonian Mathieu oscillator with parametric and forcing excitations
Vanvinckenroye, Hélène ULg; Denoël, Vincent ULg

in Journal of Sound and Vibration (in press)

A linear oscillator simultaneously subjected to stochastic forcing and parametric excitation is considered. The time required for this system to evolve from a low initial energy level until a higher ... [more ▼]

A linear oscillator simultaneously subjected to stochastic forcing and parametric excitation is considered. The time required for this system to evolve from a low initial energy level until a higher energy state for the first time is a random variable. Its expectation satisfies the Pontryagin equation of the problem, which is solved with the asymptotic expansion method developed by Khasminskii. This allowed deriving closed-form expressions for the expected first passage time. A comprehensive parameter analysis of these solutions is performed. Beside identifying the important dimensionless groups governing the problem, it also highlights three important regimes which are called incubation, multiplicative and additive because of their specific features. Those three regimes are discussed with the parameters of the problem. [less ▲]

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See detailPotential demal exposure of florists to fungicide residues on flowers and risk assessment
Toumi; Joly, L.; Vleminckx, C. et al

in Communications in Agricultural and Applied Biological Sciences (in press)

Flowers are susceptible to many pests and diseases. Therefore, they can be sprayed several times during their growth considering that no MRL are set for flow-ers. High levels of pesticide residues ... [more ▼]

Flowers are susceptible to many pests and diseases. Therefore, they can be sprayed several times during their growth considering that no MRL are set for flow-ers. High levels of pesticide residues potentially expose daily the florists who han-dle cut flowers and possibly could endanger their health. A study was carried out to evaluate the risk for florists exposed to fungicide residues during normal profes-sional tasks. Cotton gloves were distributed to 20 florists (two pairs to each florist) and worn during two consecutive half days during normal professional tasks (from min 2 hours to max 3 hours/day) to measure their potential dermal exposure (PDE). Samples were analyzed with a multi-residue (QuEChERS) method validated by a laboratory accredited for pesticide residues and with a combination of gas and liquid chromatography tandem mass spectrometry. It appears from the results that a total of 54 fungicides with different toxicity classes were detected on cotton gloves. An average of 15.53 mg/kg fungicide residues per glove sample was meas-ured. Six of 54 are suspected of causing cancer after prolonged or repeated expo-sure. Boscalid was both the active substance for which the highest maximum and average concentrations (26.21 and 3.47 mg/kg, respectively). Famoxadone had the most critical PDE (156% AOEL for the maximum concentration). As a consequence, this study leads to conclude that Belgian florists, who worked for several years and handled a large number of flowers contaminated by high concentrations of pesti-cide residues, are exposed daily with a potential effect on their health. This sug-gests that safety standards should be set for residue levels on cut flowers. [less ▲]

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See detailSacred Alliance or Pact with the Devil? How and Why Social Enterprises Collaborate with Mainstream Businesses in the Fair Trade Sector
Huybrechts, Benjamin ULg; Nicholls, Alex; Edinger, Katharina

in Entrepreneurship and Regional Development (in press)

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises ... [more ▼]

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises interact with mainstream businesses and to what extent their collaboration patterns reflect a vision of how their social mission should be implemented and institutionalized. The empirical analysis is derived from a qualitative study of ‘fair trade’ – a hybrid model created by social enterprises and using market mechanisms to support small-scale producers in developing countries and to advocate for changes in international trading practices. The findings highlight three strategies used by fair trade social enterprises to manage their interactions with mainstream businesses: sector solidarity, selective engagement, and active appropriation. This paper suggests that each strategy is motivated by a different vision of how best to articulate the social mission of fair trade via specific types of collaborations. It also notes how each vision has a distinct pattern of institutionalization at the field level. This paper adds to the emergent literatures on social enterprise and social entrepreneurship, fair trade, cross-sector collaboration and hybrid organizing. [less ▲]

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See detailOutbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in southwest Niger
Kouato; Fana, EM; King, DP et al

in Transboundary and Emerging Diseases (in press)

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See detailDo sex reversal procedures differentially affect agonistic behaviours and sex steroid levels depending on the sexual genotype in Nile tilapia?
Gennotte, Vincent ULg; Akonkwa, Balagizi; Mélard, Charles ULg et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (in press)

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY ... [more ▼]

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY males, XY and YY females, and XX males expressed higher level of aggressiveness that could be related to higher levels of 17β-oestradiol and 11-ketotestosterone respectively. Our results suggest that the presence of a Y chromosome increases aggressiveness in females. However, since the same relationship between aggressiveness and the Y chromosome is not observed in males, we can hypothesize that the differences in aggressiveness are not directly dependent on the genotype but on the sex reversal procedures applied on young fry during their sexual differentiation to produce these breeders. These hormonal treatments could have permanently modified the development of the brain and consequently influenced the behaviour of adults independently of their genotype. In both hypotheses (genotype or sex reversal influence), the causes of behavioural modifications have to be searched in an early modification of the brain sexual differentiation. [less ▲]

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See detailL'espace transitionnel winnicotien et l'_Urraum_ kantien
Seba, Jean-Renaud ULg

in Revista Natureza Humana (in press)

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See detailOn the phase behaviour of oxetane-CO2 and propargylic alcohols-CO2 binary mixtures by in situ infrared micro-spectrometry
Zaky, Mohamed; Boyaval, Amélie ULg; Grignard, Bruno ULg et al

in Journal of Supercritical Fluids (in press)

The phase behaviour of carbon dioxide/propargylic alcohols and carbon dioxide/oxetanes mixtures has been investigated using in-situ FTIR microspectrometry that allows us determining the evolution of the ... [more ▼]

The phase behaviour of carbon dioxide/propargylic alcohols and carbon dioxide/oxetanes mixtures has been investigated using in-situ FTIR microspectrometry that allows us determining the evolution of the concentration of each component in the liquid phase as a function of temperature and pressure. It was at the same time possible to look inside the cell and to visualize the expansion of the liquid phase during the increase of the pressure. The measurements were performed at three different temperatures (40, 70 and 100◦C) for pressures ranging between 0.1 and 15 MPa. Propargylic alcohol (PA), 2-methyl-3-butyn-2-ol (MBOL), 3-butyn-1-ol (BOL) and trimethylene oxide (TMO) were selected as these molecules are used in the synthesis of cyclic or polycarbonates by coupling with CO2. Thus, we determined the CO2 sorption and the concentration of the substrate in the liquid phase. Thanks to these measurements, we established the pressure-composition phase diagram for the liquid phase of these substrate/CO2 binary mixtures. [less ▲]

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See detailLe populisme aux Etats-Unis
Jamin, Jérôme ULg

in Revue de la Faculté de Droit de l'Université de Liège (in press)

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See detailA damage to crack transition model accounting for stress triaxiality formulated in a hybrid non-local implicit discontinuous Galerkin - cohesive band model framework
Leclerc, Julien ULg; Wu, Ling ULg; Nguyen, Van Dung ULg et al

in International Journal for Numerical Methods in Engineering (in press)

Modelling the entire ductile fracture process remains a challenge. On the one hand, continuous damage models succeed in capturing the initial diffuse damage stage but are not able to represent ... [more ▼]

Modelling the entire ductile fracture process remains a challenge. On the one hand, continuous damage models succeed in capturing the initial diffuse damage stage but are not able to represent discontinuities or cracks. On the other hand, discontinuous methods, as the cohesive zones, which model the crack propagation behaviour, are suited to represent the localised damaging process. However, they are unable to represent diffuse damage. Moreover, most of the cohesive models do not capture triaxiality effect. In this paper, the advantages of the two approaches are combined in a single damage to crack transition framework. In a small deformation setting, a non-local elastic damage model is associated with a cohesive model in a discontinuous Galerkin finite element framework. A cohesive band model is used to naturally introduce a triaxiality-dependent behaviour inside the cohesive law. Practically, a numerical thickness is introduced to recover a 3D-state, mandatory to incorporate the in-plane stretch effects. This thickness is evaluated to ensure the energy consistency of the method and is not a new numerical parameter. The traction-separation law is then built from the underlying damage model. [less ▲]

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See detailMartin Heidegger, Extrait du dernier cours de Marbourg
Pieron, Julien ULg

in Philosophie (in press)

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See detailChondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Sanchez, Christelle ULg; Bay-Jensen, Anne-Christine; Pap, Thomas et al

in Osteoarthritis and Cartilage (in press)

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See detailA multifractal formalism for non-concave and non-increasing spectra: the leaders profile method
Esser, Céline ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

in Applied & Computational Harmonic Analysis (in press)

We present an implementation of a multifractal formalism based on the types of histogram of wavelet leaders. This method yields non-concave spectra and is not limited to their increasing part. We show ... [more ▼]

We present an implementation of a multifractal formalism based on the types of histogram of wavelet leaders. This method yields non-concave spectra and is not limited to their increasing part. We show both from the theoretical and from the applied points of view that this approach is more e cient than the wavelet-based multifractal formalisms previously introduced. [less ▲]

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See detailIdentification of bacterial strains isolated from the traditional date product "Btana" produced in south regions of Algeria
Abekhti, Abdelkader; Taminiau, Bernard ULg; Kihal, Mabrouk et al

in Folia Microbiologica (in press)

Eleven samples of the traditional date product " Btana" prepared by direct (DBM) and indirect method (UBM) were analysed to characterize their bacterial diversity. A total of 42 representative isolates ... [more ▼]

Eleven samples of the traditional date product " Btana" prepared by direct (DBM) and indirect method (UBM) were analysed to characterize their bacterial diversity. A total of 42 representative isolates have been chosen for molecular identification. 16S rRNA gene sequencing revealed the presence of 20 species within 30.9% belonged to the genus Bacillus, 28.6% of the Staphylococcus, and Enterococcus genus. Within the minority represented species, two isolates were identified as Paenibacillus (isolated from UBM exclusively), Streptococci salivarius, Lactobacillus sakei and Klebsiella pneumoniae. Preliminary results indicate that IBM is more selective for spore former bacilli contrary to DBM that show more diversity in the bacterial flora with a prevalence of Enterococcus. API ZYM test showed that the bacilli species have a weak hydrolase activity. [less ▲]

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See detailNeeds-Supplies Fit and Behavioral Outcomes: The Mediating Role of Organizational Identification
Travaglianti, Fabrice ULg; Babic, Audrey ULg; Pepermans, Roland et al

in Journal of Management & Organization (in press)

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See detailNine facultative endosymbionts in aphids. A review
Guo, Jianqing ULg; Hatt, Séverin ULg; He, Kanglai et al

in Journal of Asia-Pacific Entomology (in press)

Aphids are frequently engaged in mutualistic associations with endosymbionts. Symbionts are bacterial or fungal microorganisms that can be obligate or facultative to aphids. Research showed facultative ... [more ▼]

Aphids are frequently engaged in mutualistic associations with endosymbionts. Symbionts are bacterial or fungal microorganisms that can be obligate or facultative to aphids. Research showed facultative (or secondary) symbionts have numerous effects on their host aphids such as resistance to heat shock, parasitoids and fungus etc., which may consequently promote a co-evolution between symbionts and hosts. However, this symbiotic relation may be affected by several factors, such as the ability of symbionts to spread from aphids to others within and across populations, and the cost of infections for hosts. Moreover, aphid-symbionts interactions may be affected by aphid living environment such as its host plant, the presence of natural enemies or the temperature. Here we firstly described the functions of nine facultative symbionts (Serratia symbiotica, Hamiltonella defensa, Regiella insecticola, Rickettsia, Rickettsiella, PAXS (pea aphid X-type symbiont), Spiroplasma, Wolbachia and Arsenophonus) studied in aphids one by one, and discussed the associations between these symbionts and aphids, plants and environment. We aim to have a better knowledge of the roles the facultative symbionts play in aphid biology, ecology and evolution, which we believe can provide new inspirations for aphid control. [less ▲]

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See detailFair Trade Milk Initiative in Belgium: Bricolage as an Empowering Strategy for Change
Feyereisen, Marlène ULg; Stassart, Pierre M ULg; Melard, François ULg

in Sociologia Ruralis (in press)

In a context of multiple crises, dairy farmers struggle to receive a fair remuneration for their work. This situation led to the creation of fair milk projects in Europe. But fair trade projects often ... [more ▼]

In a context of multiple crises, dairy farmers struggle to receive a fair remuneration for their work. This situation led to the creation of fair milk projects in Europe. But fair trade projects often suffer from ambiguous interpretations that place them simultaneously in and against the market. This study focuses on a Belgian milk label in order to analyse how dairy farmers developed a particular strategy to create their own fair milk. Based on semi-structured interviews and using the multi-level perspective, we propose that articulating the concepts of lock-ins, bricolage and ambiguity enables us to analyse the potential of this innovation for the transition of the Belgian dairy system. The study shows that fairness is often a matter of divergent interpretations, and its final actualisation is the product of emergent and negotiated relations. By using bricolage practices, the stakeholders reinforced their capacity to gain market power and act within the system they want to change. [less ▲]

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See detailNo post-no core approach to restore severely damaged posterior teeth: An up to 10-year retrospective study of documented endocrown cases
BELLEFLAMME, Marcia ULg; Geerts, Sabine ULg; LOUWETTE, Marie ULg et al

in Journal of Dentistry (in press)

Objectives The objectives of the present study were to (1) retrospectively evaluate documented cases of ceramic and composite endocrowns performed using immediate dentin sealing (IDS); (2) correlate ... [more ▼]

Objectives The objectives of the present study were to (1) retrospectively evaluate documented cases of ceramic and composite endocrowns performed using immediate dentin sealing (IDS); (2) correlate failures with clinical parameters such as tooth preparation characteristics and occlusal parameters. Methods 99 documented cases of endocrowns were evaluated after a mean observation period of 44.7 ± 34.6 months. A classification of restorations was established in function of the level of damage of residual tooth tissues after preparation, from 1 to 3. Evaluation was performed according to FDI criteria and endodontic outcomes were analyzed. Occlusal risk factors were examined and fractographic analysis was performed in case of fracture. Results 48.4% of patients were shown to present occlusal risk factors. 75.8% of restorations were Class 3 endocrowns. 56.6% were performed on molars, 41.4% on premolars and 2.0% on canines. 84.8% were performed in lithium-disilicate glass-ceramic and 12.1% in Polymer-Infiltrated Ceramic Network (PICN) material. The survival and success rates of endocrowns were 99.0% and 89.9% respectively, while the 10-year Kaplan-Meier estimated survival and success rates were 98.8% and 54.9% respectively. Ten failures were detected: periodontal disease (n = 3), endocrown debonding (n = 2), minor chipping (n = 2), caries recurrence (n = 2) and major fractures (n = 1). Due to the reduced amount of failures, no statistical correlation could be established with clinical parameters. Conclusions Endocrowns were shown to constitute a reliable approach to restore severely damaged molars and premolars, even in the presence of extensive coronal tissue loss or occlusal risk factors, such as bruxism or unfavorable occlusal relationships. Clinical significance Practitioners should consider the endocrown instead of the post and core approach to restore severely damaged non-vital posterior teeth. This minimally invasive solution reduces the risk of catastrophic failures and is easily performed. The use of IDS procedure and lithium-disilicate glass-ceramic as prosthesis material gave very good results. [less ▲]

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See detailMapping degenerate vortex states in a kagomé lattice of elongated antidots via scanning Hall probe microscopy
Xue, Cun; Ge, Jun-Yi; He, An et al

in Physical Review. B : Condensed Matter (in press)

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe ... [more ▼]

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe microscopy (SHPM). The observed vortex patterns, at specifi c applied magnetic fi elds, are in good agreement with the confi gurations obtained using time-dependent Ginzburg-Landau (TDGL) simulation. Both results indicate that the long range interaction in this nano-structured superconductor is unable to lift degeneracy between different vortex states and the pattern formation is mainly ruled by the nearest neighbour interaction. This simpli cation allows the identi cation of a set of simple rules characterizing the vortex con gurations. We demonstrated that these rules can explain both the observed vortex distributions and the magnetic fi eld dependent degree of degeneracy. [less ▲]

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See detailArtù italiano e iberico. Appunti in margine ai volumi VII e VIII di ALMA
Morato, Nicola ULg

in Revista de Literatura Medieval (in press), 28

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See detailLa légation des Pays-Bas et de la Franche-Comté en cour de Rome sous Philippe II (1573-1598). Entre limites institutionnelles et efficacité pragmatique
Regibeau, Julien ULg

in Forum Romanum Belgicum (in press)

Dans le dernier quart du XVIe siècle, Philippe II d’Espagne est à la tête de l’ensemble territorial le plus puissant d’Europe. Fils préféré de l’Église romaine et souverain reconnu d’une grande partie de ... [more ▼]

Dans le dernier quart du XVIe siècle, Philippe II d’Espagne est à la tête de l’ensemble territorial le plus puissant d’Europe. Fils préféré de l’Église romaine et souverain reconnu d’une grande partie de l’Italie, il exerce une influence considérable sur la papauté à travers l’action de son ambassadeur espagnol résidant près le Saint-Siège. Ce dernier a pour tâche d’étendre le réseau des alliés au sein de la Curie. Il chapeaute aussi les différents services diplomatiques et ecclésiastiques des États de la monarchie présents dans la cité des papes . Si elle conserve une certaine autonomie, la légation des Pays-Bas et de la Franche-Comté près le Saint-Siège – conduite par l’agent Laurent du Blioul de 1573 à 1598 – est également soumise à la volonté de cet envoyé. Ce n’est d’ailleurs pas un hasard si l’étude de la légation à l’époque du règne de Philippe II a peu passionné les historiens . Effacée derrière la puissance de l’ambassadeur espagnol, celle-ci semble être un piètre avatar des services ecclésiastiques et diplomatiques dépêchés à Rome par les ducs de Bourgogne , Philippe le Beau ou les archiducs Albert et Isabelle . Or, si, aux temps de Laurent du Blioul, la légation, considérée en tant qu’actrice isolée dans le paysage romain, joue un rôle modeste qui se cantonne au suivi des affaires ecclésiastiques provenant des Pays-Bas et de la Franche-Comté, il faut envisager qu’elle fait partie intégrante d’une toile religieuse, diplomatique, sociale et politique plus vaste tissée à Rome par le roi Philippe II et ses agents. Dépassant les seuls intérêts des Pays-Bas, l’étude de cette institution conduit à appréhender tout un pan de la stratégie politique habsbourgeoise. L’imbrication de la légation dans le théâtre diplomatique espagnol à Rome a deux facettes : si, d’une part, elle limite les prérogatives institutionnelles de l’agent du Blioul, d’autre part, elle favorise régulièrement l’efficacité de son action. [less ▲]

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See detailProtein requirements of collared peccary (Pecari tajacu)
Borges, Rogerio; Mendes, Alcester; Nogueira, Selene et al

in Tropical Animal Health and Production (in press)

A nitrogen (N) balance digestion trial was conducted to determine the protein requirement of collared peccaries (Pecari tajacu). In a 4 × 4 Latin square design, four captive adult male peccaries were fed ... [more ▼]

A nitrogen (N) balance digestion trial was conducted to determine the protein requirement of collared peccaries (Pecari tajacu). In a 4 × 4 Latin square design, four captive adult male peccaries were fed four isoenergy diets containing four different levels of N (11.7, 16.3, 22.8, and 26.7 g N/kg of dry matter—DM). After 15 days of adaptation, a total collection of feces and urine was carried out for five consecutive days. Regression analyses between N intake and N in feces and urine allowed to calculate the metabolic fecal nitrogen (MFN = 2.3 g N/kg of dry matter intake—DMI) and daily endogenous urinary N (EUN = 185 mg N/kg0.75). Likewise, by regression analyses between consumption of nitrogen and the nitrogen balance (NB = N ingested − N excreted, mg N/kg0.75), a daily requirement of 514 mg N/kg0.75 was calculated. Therefore, if food intake is unrestricted, collared peccaries require a minimumin their diet of about 5.4% crude protein on DM basis. These values are almost as low as those found for browsing and frugivorous wild ruminants, which reinforce the proposition that peccaries’ digestive physiology is nearer to that of domestic and wild ruminants than domestic pigs. This relatively low protein requirement of collared peccary and its great ability to digest protein reveal the relevance of the forestomach for the species on nitrogen/protein metabolism and allow the use of diets with lower crude protein levels than the commercial ones used for the domestic pig, which reduces feed costs. [less ▲]

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See detailAn active bacterial community linked to high chl-a concentrations in Antarctic winter-pack ice and evidence for the development of an anaerobic sea-ice bacterial community
Eronen-Rasimus, Eeva; Luhtanen, Anne-Mari; Rintala, Janne-Markus et al

in ISME Journal (The) (in press), 1-11

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to ... [more ▼]

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to high (o4 μg l–1) chlorophyll-a (chl-a) concentrations and consequent bacterial production. Typical sea-ice bacterial genera, for example, Octadecabacter, Polaribacter and Glaciecola, often abundant in spring and summer during the sea-ice algal bloom, predominated in the communities. The variability in bacterial community composition in the different ice types was mainly explained by the chl-a concentrations, suggesting that as in spring and summer sea ice, the sea-ice bacteria and algae may also be coupled during the Antarctic winter. Coupling between the bacterial community and sea-ice algae was further supported by significant correlations between bacterial abundance and production with chl-a. In addition, sulphate-reducing bacteria (for example, Desulforhopalus) together with odour of H2S were observed in thick, apparently anoxic ice, suggesting that the development of the anaerobic bacterial community may occur in sea ice under suitable conditions. In all, the results show that bacterial community in Antarctic sea ice can stay active throughout the winter period and thus possible future warming of sea ice and consequent increase in bacterial production may lead to changes in bacteria-mediated processes in the Antarctic sea-ice zone. [less ▲]

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See detailNow we're free. De lichtheid van Leonard Cohen in You want it darker (2016)
Mus, Francis ULg

in Passage, tijdschrift voor Europese literatuur en cultuur (in press)

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See detailMorphological integration and alternative life history strategies: a case study in a facultatively paedomorphic newt
Tomašević, Natasa; Cvijanović, Milena; Denoël, Mathieu ULg et al

in Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution (in press)

Tetrapod limbs are serially homologous structures that represent a particularly interesting model for studies on morphological integration, i.e. the tendency of developmental systems to produce correlated ... [more ▼]

Tetrapod limbs are serially homologous structures that represent a particularly interesting model for studies on morphological integration, i.e. the tendency of developmental systems to produce correlated variation. In newts, limbs develop at an early larval stage and grow continuously, including after the habitat transition from water to land following metamorphosis. However, aquatic and terrestrial environments impose different constraints and locomotor modes that could affect patterns of morphological integration and evolvability. We hypothesize that this would be the case for alternative heterochronic morphs in newts, i.e. aquatic paedomorphs that keep gills at the adult stage and adult metamorphs that are able to disperse on land. To this end, we analysed patterns and strengths of correlations between homologous skeletal elements of the fore- and hindlimbs as well as among skeletal elements within limbs in both phenotypes in the alpine newt, Ichthyosaura alpestris. Our results showed that metamorphs and paedomorphs had similar, general patterns of limb integration. Partial correlations between homologous limb elements and within limb elements were higher in paedomorphs when compared to metamorphs. Decrease in partial correlation between homologous limb elements in metamorphs is accompanied with a higher evolvability of the terrestrial morph. All these results indicate that environmental demands shaped the patterns of morphological integration of alpine newt limbs and that the observed diversity in correlation structure could be related to a qualitative difference in the modes of locomotion between the morphs. [less ▲]

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See detailDevelopment trajectory of an integrated framework for the mitigation of future flood risk: results from the FloodLand project
Saadi, Ismaïl ULg; Bruwier, Martin ULg; El Saeid Mustafa, Ahmed Mohamed ULg et al

in Transportation Letters: The International Journal of Transportation Research (in press)

In this paper, the development trajectory of an integrated framework for the mitigation of future flood risk of the Ourthe river basin in Belgium is discussed. The paper contributes to the state-of-the ... [more ▼]

In this paper, the development trajectory of an integrated framework for the mitigation of future flood risk of the Ourthe river basin in Belgium is discussed. The paper contributes to the state-of-the-art by presenting an integrated multidisciplinary framework capable of making long-term projections (time horizon 2050 and 2100) with the objective of mitigating future flood risk by proposing alternative land-use scenarios. It bridges numerous different fields, including urban planning, transport engineering, hydrology, geology, environmental engineering, and economics. The overall design and validation results of the different sub-modules of the framework are presented, and ongoing and future enhancements are highlighted. [less ▲]

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See detailVisualiser la variation et le changement valenciel: structure des compléments datifs dans l’histoire du français
Mazziotta, Nicolas ULg

in Linguisticae Investigationes (in press)

Il est possible de modéliser la variation et le changement valenciel à l'aide des structures formelles que nous nommons _polygraphes_. Ces derniers étendent les arbres syntaxiques dépendanciels en ... [more ▼]

Il est possible de modéliser la variation et le changement valenciel à l'aide des structures formelles que nous nommons _polygraphes_. Ces derniers étendent les arbres syntaxiques dépendanciels en autorisant des relations à porter sur d'autres relations. En prenant l'exemple de l'expression prépositionnelle ou non du datif en ancien français et en français moderne (complément des verbes _donner_, _aider_, et _pardonner_), nous montrons comment les polygraphes peuvent être employés pour montrer géométriquement la différence entre une préposition obligatoire et une préposition facultative. Le potentiel de ces structures permet également de visualiser l'évolution et de comparer le comportement des lexèmes. [less ▲]

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See detailReconstructing the times of past and future personal events
Ben Malek, Mohamed Hedi ULg; Berna, Fabrice; D'Argembeau, Arnaud ULg

in Memory (in press)

Humans have the remarkable ability to mentally travel through past and future times. However, while memory for the times of past events has been much investigated, little is known about how imagined ... [more ▼]

Humans have the remarkable ability to mentally travel through past and future times. However, while memory for the times of past events has been much investigated, little is known about how imagined future events are temporally located. Using a think-aloud protocol, we found that the temporal location of past and future events is rarely directly accessed, but instead mostly relies on reconstructive and inferential strategies. References to lifetime periods and factual knowledge (about the self, others, and the world) were most frequently used to determine the temporal location of both past and future events. Event details (e.g., places, persons, or weather conditions) were also used, but mainly for past events. Finally, the results showed that events whose temporal location was directly accessed were judged more important for personal goals. Together, these findings shed new light on the mechanisms involved in locating personal events in past and future times. [less ▲]

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See detailIron and Trace Element in Paediatric Parenteral Nutrition
Domellof, M; Szitanyi, P; Simchowitz, V et al

in Clinical Nutrition (in press)

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See detailLa question de l’éducation : aiguillon des philosophies politiques. Castoriadis/Rancière.
Wustefeld, Sophie ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

La démocratie reste un thème chéri par la philosophie politique contemporaine, pour l’écart entre ses théories et ses pratiques, pour la distance critique que ses théories offrent vis-à-vis des régimes ... [more ▼]

La démocratie reste un thème chéri par la philosophie politique contemporaine, pour l’écart entre ses théories et ses pratiques, pour la distance critique que ses théories offrent vis-à-vis des régimes démocratiques et de leur évolution, mais aussi parce qu’elle est un objet perpétuel de dissensus entre philosophes, au sujet duquel toute prétention à la véridiction est suspendue à sa réalisation pratique. À ce titre, la transmission de la volonté démocratique est un topos houleux de la philosophie politique contemporaine. Cette question catalyse les concepts pivots des philosophies politiques, la leur poser permet de mieux saisir les enjeux rivaux derrière une terminologie commune à plusieurs auteurs. C’est dans cette démarche que je vous propose d’examiner en miroir les philosophies de Cornélius Castoriadis et de Jacques Rancière. De plus en plus nombreux, des commentateurs rapprochent leurs pensées , qui peuvent s’appuyer sur plusieurs points communs : un attachement au concept de démocratie brandit contre les régimes parlementaires, une opposition contemporaine (quoique depuis des héritages différents) aux thèses défendues par Althusser, et une proximité de sources d’inspirations : la philosophie, le marxisme, et la psychanalyse. Partant de la manière dont cette proximité s’exprime dans la disjonction que chacun opère entre démocratie et science, je tenterai de discerner comment les inflexions qu’ils impriment aux concepts de volonté et d’égalité sous la guise des enjeux de la transmission dessinent des horizons politiques distincts, et dénotent des compréhensions antithétiques – mais indécidables dans la théorie – de ce que peut être la démocratie. [less ▲]

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See detailFamiliennamen zwischen Maas und Rhein
Möller, Robert ULg

in Rheinische Vierteljahrsblätter (in press)

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See detailContribution à un lexique épigraphique: "deltographéma"
Famerie, Etienne ULg

in Zeitschrift für Papyrologie und Epigraphik (in press)

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See detailCO2-sourced α-alkylidene cyclic carbonates: a Step forward in the quest for functional regioregular poly(urethane)s and poly(carbonate)s
Gennen, Sandro ULg; Grignard, Bruno ULg; Tassaing, Thierry et al

in Angewandte Chemie International Edition (in press)

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene ... [more ▼]

We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene carbonates by various nucleophiles. The remarkable reactivity of α-alkylidene carbonates is dictated by the exocyclic olefinic group that selectively orients the cyclic carbonate ring- opening with the formation of an enol species. The polyaddition of CO2 -sourced bis-α-alkylidene carbonates (bis-αCCs) with primary and secondary diamines provides novel regioregular functional poly(urethane)s. The reactivity of bis-αCCs is also exploited for producing new poly(β-oxo-carbonate)s by organocatalyzed polyaddition with a diol. All polyadditions were feasible under ambient conditions. This synthesis platform provides new functional variants of world-class leading polymers families (polyurethanes, polycarbonates) and valorises CO2 as a chemical feedstock. [less ▲]

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See detailFigement, langage et didactique du français langue première
Steffens, Marie ULg

in Langues et Linguistique (in press), (36),

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See detailOutcome after failure of allogeneic hematopoietic stem cell transplantation in children with acute leukemia: a study by the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Rorhlich; Roux, C; Tifratene, K et al

in Bone Marrow Transplantation (in press)

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation relapse. We aimed to compare treatment strategies in 334 consecutive children with acute leukemia relapse or progression after SCT in a recent ten-year period. Data could be analyzed in 288 patients (157 ALL, 123 AML and 8 biphenotypic AL) with a median age of 8.16 years at transplantation. The median delay from first SCT to relapse or progression was 182 days. The treatment consisted in chemotherapy alone (n=108), chemotherapy followed by second SCT (n=70), supportive/palliative care (n=67), combination of chemotherapy and DLI (n=30), or isolated reinfusion of donor lymphocytes (DLI) (n=13). The median OS duration after relapse was 164 days and differed according to therapy: DLI after chemotherapy = 385 d, second allograft = 391d, chemotherapy = 174d, DLI alone = 140d, palliative care = 43d. A second SCT or a combination of chemotherapy and donor lymphocytes infusion yielded similar outcome (HR=0.85, p=0.53) unlike chemotherapy alone (HR 1.43 p=0.04), palliative care (HR=4.24, p<0.0001) or isolated DLI (HR=1,94, p<0.04). Despite limitations in this retrospective setting, strategies including immunointervention appear superior to other approaches, mostly in AML. [less ▲]

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See detailAssessment of Continuous Pain in Newborns admitted to NICUs in 18 European Countries
Anand, Kanwaljeet; Eriksson, Mats; Boyle, Elaine et al

in Acta Paediatrica (in press)

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A ... [more ▼]

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A prospective cohort study in 243 Neonatal Intensive Care Units (NICUs) from 18 European countries recorded frequency of pain assessments, use of mechanical ventilation, sedation, analgesia, or neuromuscular blockade for each neonate upto 28 days after NICU admission. Results: Only 2113/6648 (31·8%) of neonates received assessments of continuous pain, occurring variably among tracheal ventilation (TrV, 46·0%), noninvasive ventilation (NiV, 35· 0%), and no ventilation (NoV, 20· 1%) groups (p<0· 001). Daily assessments for continuous pain occurred in only 10·4% of all neonates (TrV: 14· 0%, NiV: 10· 7%, NoV: 7· 6%; p<0· 001). More frequent assessments of continuous pain occurred in NICUs with pain guidelines, nursing champions, and surgical admissions prompted (all p<0·01), and for newborns <32 weeks gestational age, those requiring ventilation, or opioids, sedatives-hypnotics, general anesthetics (O-SH-GA) (all p<0·001), or surgery (p=0· 028). Use of O-SH-GA drugs increased the odds for pain assessment in the TrV (OR:1· 60, p<0·001) and NiV groups (OR:1·40, p<0· 001). Conclusion: Assessments of continuous pain occurred in less than one-third of NICU admissions, and daily in only 10% of neonates. NICU clinical practices should consider including routine assessments of continuous pain in newborns. [less ▲]

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See detailOn the finiteness of the weighted likelihood estimator of ability
Magis, David ULg; Verhelst, Norman

in Psychometrika (in press)

The purpose of this note is to focus on the finiteness of the weighted likelihood estimator (WLE) of ability in the context of dichotomous and polytomous item response theory (IRT) models. It is ... [more ▼]

The purpose of this note is to focus on the finiteness of the weighted likelihood estimator (WLE) of ability in the context of dichotomous and polytomous item response theory (IRT) models. It is established that the WLE always returns finite ability estimates. This general result is valid for dichotomous (one-, two-, three- and four-parameter logistic) IRT models, the class of polytomous difference models and divide-by-total models, independently of the number of items, the item parameters and the response patterns. Further implications of this result are outlined. [less ▲]

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See detailBehaviour and browse species selectivity of heifers grazing in a temperate silvopastoral system
Vandermeulen, Sophie ULg; Ramírez-Restrepo, Carlos Alberto; Marche, Christian et al

in Agroforestry Systems (in press)

In Belgium silvopastoral grazing systems associating trees and pasture are instrumental in enhancing dynamic trade-offs between ruminant farming and habitat improvement. A 130-day study was conducted in ... [more ▼]

In Belgium silvopastoral grazing systems associating trees and pasture are instrumental in enhancing dynamic trade-offs between ruminant farming and habitat improvement. A 130-day study was conducted in Belgium from April to September 2013 to evaluate the effects of browsing a combination of shrubs and trees (i.e. hedge) on the selective behaviour of cattle and to relate these observations to changes in forage nutritive value. Twelve Holstein dairy heifers (Bos taurus; 487 kg) were allocated to either a control ryegrass pasture (i.e. control pasture group; CPG) or a pasture plus unrestricted browsing (i.e. browsing group; BG) of a hedge composed of shrubs and trees. Behaviour and selectivity towards the woody species were recorded for 14h on a daily basis during 3 consecutive days over spring, early summer and late summer. Leaves and stems of woody species and faecal samples were collected during each season to analyse their nutritive value and predict the dry matter intake by means of near infrared reflectance spectroscopy. Integrating shrubs and trees along a pasture influenced the heifers’ behaviour and BG heifers spent 19.3, 5.9 and 5.4% of their time browsing during spring, and early and late summer, respectively (P < 0.001). This behaviour was correlated to the pre-grazing pasture biomass (r=0.50; P < 0.001). Compared with the summer seasons, the greater browsing activity in spring was associated with higher plant feeding value. Overall, the most ingested species were Carpinus betulus, Cornus sanguinea, Corylus avellana and Crataegus monogyna. It was concluded that cattle use a significant time budget for browsing on temperate ryegrass pasture but further research is required to investigate potential benefits of silvopastoral systems in Belgium. [less ▲]

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See detailOrganisational aspects of paediatric parenteral nutrition
Puntis, J; Hojsak, I; Ksiazyk, J et al

in Clinical Nutrition (in press)

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See detailThe effect of spaceflight and microgravity on the human brain
Van Ombergen, Angelique; Demertzi, Athina ULg; Tomilovskaya et al

in Journal of Neurology (in press)

Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental ... [more ▼]

Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental effects on human physiology. Although research has focused on the cardiovascular and musculoskeletal system in particular, the exact impact of spaceflight on the human central nervous system remains to be determined. Previous studies have reported psychological problems, cephalic fluid shifts, neurovestibular problems, and cognitive alterations, but there is paucity in the knowledge of the underlying neural substrates. Previous space analogue studies and preliminary spaceflight studies have shown an involvement of the cerebellum, cortical sensorimotor, and somatosensory areas and the vestibular pathways. Extending this knowledge is crucial, especially in view of long-duration interplanetary missions (e.g., Mars missions) and space tourism. In addition, the acquired insight could be relevant for vestibular patients, patients with neurodegenerative disorders, as well as the elderly population, coping with multisensory deficit syndromes, immobilization, and inactivity. [less ▲]

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See detailMulticenter Evaluation of Cystatin C Measurement after Assay Standardization.
Bargnoux, Anne-Sophie; Pieroni, Laurence; Cristol, Jean-Paul et al

in Clinical Chemistry (in press)

BACKGROUND: Since 2010, a certified reference material ERM-DA471/IFCC has been available for cystatin C (CysC). This study aimed to assess the sources of uncertainty in results for clinical samples ... [more ▼]

BACKGROUND: Since 2010, a certified reference material ERM-DA471/IFCC has been available for cystatin C (CysC). This study aimed to assess the sources of uncertainty in results for clinical samples measured using standardized assays. METHODS: This evaluation was performed in 2015 and involved 7 clinical laboratories located in France and Belgium. CysC was measured in a panel of 4 serum pools using 8 automated assays and a candidate isotope dilution mass spectrometry reference measurement procedure. Sources of uncertainty (imprecision and bias) were evaluated to calculate the relative expanded combined uncertainty for each CysC assay. Uncertainty was judged against the performance specifications derived from the biological variation model. RESULTS: Only Siemens reagents on the Siemens systems and, to a lesser extent, DiaSys reagents on the Cobas system, provided results that met the minimum performance criterion calculated according to the intraindividual and interindividual biological variations. Although the imprecision was acceptable for almost all assays, an increase in the bias with concentration was observed for Gentian reagents, and unacceptably high biases were observed for Abbott and Roche reagents on their own systems. CONCLUSIONS: This comprehensive picture of the market situation since the release of ERM-DA471/IFCC shows that bias remains the major component of the combined uncertainty because of possible problems associated with the implementation of traceability. Although some manufacturers have clearly improved their calibration protocols relative to ERM-DA471, most of them failed to meet the criteria for acceptable CysC measurements. [less ▲]

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See detailEtre avec par corps. L'expérience du commun sur un plateau de théâtre
Servais, Véronique ULg; Brahy, Rachel ULg

in Recherches en Communication (in press)

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See detailThe use of time series forecasting in zone order picking systems to predict order pickers’ workload
van Gils, Teun; Ramaekers, Katrien; Caris et al

in International Journal of Production Research (in press)

In order to differentiate from competitors in terms of customer service, warehouses accept late orders while providing delivery in a quick and timely way. This trend leads to a reduced time to pick an ... [more ▼]

In order to differentiate from competitors in terms of customer service, warehouses accept late orders while providing delivery in a quick and timely way. This trend leads to a reduced time to pick an order. This paper introduces workload forecasting in a warehouse context, in particular a zone picking warehouse. Improved workforce planning can contribute to an effective and efficient order picking process. Most order picking publications treat demand as known in advance. As warehouses accept late orders, the assumption of a constant given demand is questioned in this paper. The objective of this study is to present time series forecasting models that perform well in a zone picking warehouse. A real-life case study demonstrates the value of applying time series forecasting models to forecast the daily number of order lines. The forecast of order lines, along with order pickers’ productivity, can be used by warehouse supervisors to determine the daily required number of order pickers, as well as the allocation of order pickers across warehouse zones. Time series are applied on an aggregated level, as well as on a disaggregated zone level. Both bottom-up and top-down approaches are evaluated in order to find the best-performing forecasting method. [less ▲]

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See detailA Quantitative Doignon-Bell-Scarf theorem
Aliev, Iskander; Bassett, Robert; De Loera, Jesus et al

in Combinatorica (in press)

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative ... [more ▼]

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative generalization: Given an integer k, we prove that there exists a constant c(n,k), depending only on the dimension n and on the number k, such that if a bounded polyhedron {x in R^n : Ax <= b} contains exactly k integer points, then there exists a subset of the rows, of cardinality no more than c(n,k), defining a polyhedron that contains exactly the same k integer points. In this case c(n,0)=2^n as in the original case of Doignon-Bell-Scarf for infeasible systems of inequalities. We work on both upper and lower bounds for the constant c(n,k) and discuss some consequences, including a Clarkson-style algorithm to find the l-th best solution of an integer program with respect to the ordering induced by the objective function. [less ▲]

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See detailVenous Access for Paediatric Parenteral Nutrition
Kolacek, S; Puntis, J; Hojsak, I et al

in Clinical Nutrition (in press)

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See detailHome Parenteral Nutrition in Paediatrics
Hill, S; Ksiaszyk, J; Prell, C et al

in Clinical Nutrition (in press)

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See detailJésus caricaturé ? À propos des Proses évangéliques
Saint-Amand, Denis ULg; Roland, Florine

in Parade Sauvage (in press), 27

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See detailComment la participation à une recherche contribue au développement professionnel : le cas des exemples à l’Université
Fossion, Gilles ULg; Faulx, Daniel ULg

in Recherches Qualitatives (in press)

La recherche scientifique constitue un des piliers centraux de l’activité universitaire. Nous nous sommes donc questionnés sur les apprentissages générés par celle-ci. Après avoir brièvement décrit les ... [more ▼]

La recherche scientifique constitue un des piliers centraux de l’activité universitaire. Nous nous sommes donc questionnés sur les apprentissages générés par celle-ci. Après avoir brièvement décrit les objectifs et enjeux de cette communication, nous proposons une présentation des objectifs et de la méthodologie de la recherche que nous avons menée au sein des Facultés de Psychologie et des Sciences de l’Éducation de l’Université de Liège. Nous poursuivons, enfin, par la mise en évidence de ses principaux résultats. Ces résultats se situent sur deux niveaux. D’une part, nous présentons les résultats inhérents à la recherche - relative aux impacts générés par la mobilisation de l’exemple au sein du discours pédagogique - et qui contribue à l’enrichissement du champ scientifique abordé. D’autre part, nous abordons les résultats qui permettent la mise en évidence de l’aspect formatif que revêt la participation à une recherche scientifique pour les acteurs. [less ▲]

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See detailFusion-based Additive Manufacturing for Processing Aluminum Alloys: State-of-the-Art and Challenges
Mertens, Anne ULg; Delahaye, Jocelyn ULg; Lecomte-Beckers, Jacqueline ULg

in Advanced Engineering Materials (in press)

Starting early 2015, the fusion-based additive manufacturing of Al alloys has been developing at an ever faster pace after undergoing a comparatively slow start with respect to other metallic materials ... [more ▼]

Starting early 2015, the fusion-based additive manufacturing of Al alloys has been developing at an ever faster pace after undergoing a comparatively slow start with respect to other metallic materials. This paper reviews the recent developments with the aim of identifying major challenges and opportunities for future work. Laser Beam Melting proves the most useful technique for the additive fabrication of Al components with strongly out-of-equilibrium microstructures and potentially enhanced mechanical behavior. Laser Cladding is also promising for specific applications such as repairs and coatings. However, a deeper understanding of the thermal history during fabrication is still needed to further optimize the microstructures and usage properties. The design of new high strength alloys and of Al-matrix composites, and the development of better adapted post-processing procedures to take greater advantage of the specificities of fusion-based additive techniques are two other important issues in view of reaching the full potential of additive Al components. [less ▲]

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See detailUltrasonic roll bite measurements in cold rolling - roll stress and deformation
Carretta, Yves; Hunter, Andrew; Boman, Romain ULg et al

in Journal of Materials Processing Technology (in press)

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip ... [more ▼]

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, several online measurements are usually carried out such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area. This paper presents a sensor capable of monitoring roll deformations as well as roll radial stresses in situ and in real time. The sensor emits ultrasonic pulses that reflect from the roll surface. The time-of-flight (ToF) of the pulses is recorded during the testing. The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under different strip elongation. Roll deformation and radial stresses obtained from the experimental data are in good agreement with numerical results computed with a cold rolling model developed in non-linear Finite Element software. [less ▲]

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See detailCytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency
Humblet-Baron, Stephanie; Schönefeldt, Susan; Garcia-Perez, Josselyn E et al

in Journal of Allergy and Clinical Immunology (The) (in press)

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA ... [more ▼]

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA recombination causes a developmental block in T cells and B cells, resulting in high susceptibility to infections. Hypomorphic mutations in the same genes can also give a partial loss of T cells, in a spectrum including leaky SCID (LS) and Omenn syndrome (OS). These patients not only develop life-threatening infections due to immunodeficiency, but also develop inflammatory/autoimmune conditions due to the presence of autoreactive T cells. Objective: We sought to develop a preclinical model that fully recapitulates the symptoms of LS/OS patients including a model for testing therapeutic intervention. Methods: We generated a novel mutant mouse (Dclre1c leaky) that develops a LS phenotype. Mice were monitored for diseases and immune phenotype and immune function were evaluated using flow cytometry, ELISA and histology. Results: Dclre1c leaky mice present with a complete blockade of B cell differentiation, with a leaky block in T cell differentiation resulting in an oligoclonal TCR repertoire and enhanced cytokine secretion. Dclre1c leaky mice also developed inflammatory symptoms including wasting, dermatitis, colitis, hypereosinophilia and high IgE levels. Development of a preclinical murine model for LS allowed the testing of potential treatment, with administration of CTLA4-Ig reducing disease symptoms and immunological disturbance, resulting in increased survival. Conclusion: These data suggest that CTLA4-Ig should be evaluated as a potential treatment of inflammatory symptoms in LS and OS patients. [less ▲]

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See detailA Piano Made in Australia: Reinventing an Emblem of Cultural Wealth in Murray Bail's The Voyage
Herbillon, Marie ULg

in Antipodes: A Global Journal of Australian/New Zealand Literature (in press), 31(2),

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See detailVieillir en bonne santé dans une société âgiste...
Adam, Stéphane ULg; Missotten, Pierre ULg; Flamion, Allison ULg et al

in NPG. Neurologie - Psychiatrie - Gériatrie (in press)

La vision actuelle du vieillissement est principalement négative, teintée du phénomène d’âgisme (c’est-à-dire toutes les formes de discrimination, de ségrégation ou de mépris fondées sur l’âge). Une telle ... [more ▼]

La vision actuelle du vieillissement est principalement négative, teintée du phénomène d’âgisme (c’est-à-dire toutes les formes de discrimination, de ségrégation ou de mépris fondées sur l’âge). Une telle image de la vieillesse n’est pas anodine. Dans cet article, nous passerons en revue les manifestations de l’âgisme dans notre vie quotidienne, ses origines, ses implications sur nos attitudes, de même que les conséquences qui en résultent pour les personnes âgées. Nous discuterons également de certains enjeux cliniques et éthiques en lien avec ces attitudes âgistes [less ▲]

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See detailSocial sustainability assessments in the biobased economy: Towards a systemic approach
Rafiaani, Parisa ULg; Kuppens, Tom; Van Dael, Miet et al

in Renewable & Sustainable Energy Reviews (in press)

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a ... [more ▼]

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a modified systemic approach for a social sustainability impact assessment of the biobased economy, based on a review on the common methodologies for assessing social impacts. Accordingly, the proposed approach follows the four general iterative steps of social life cycle analysis (SLCA) as it considers all life cycle phases of the biobased economy. The systemic approach considers the potential social impacts on local communities, workers, and consumers as the main three groups of the stakeholders. The review showed that the most common social indicators for inventory analysis within the biobased economy include health and safety, food security, income, employment, land- and worker-related concerns, energy security, profitability, and gender issues. Multi-criteria decision analysis (MCDA) was also highlighted as the broadly utilized methodology for aggregating the results of impact assessments within the biobased economy. Taking a life cycle perspective, this study provides a holistic view of the full sustainability of research, design, and innovation in the biobased economy by suggesting the integration of the social aspects with techno-economic and an environmental life cycle assessment. Our proposed systemic approach makes possible to integrate the social impacts that are highly valued by the affected stakeholders into the existing sustainability models that focus only on environmental and techno-economic aspects. We discuss the steps of the proposed systemic approach in order to identify the challenges of applying them within the biobased economy. These challenges refer mainly to the definition of the functional unit and system boundaries, the selection and the analysis of social indicators (inventory analysis), the aggregation of the inventory to impact categories, and the uncertainties associated with the social sustainability evaluation. The result of this review and the proposed systemic approach serve as a foundation for industry and policy makers to gain a better insight into the importance of social sustainability impacts assessment within the biobased economy. [less ▲]

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See detailThe miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development
Van Den Ackerveken, Priscilla ULg; Mounier, Anaïs ULg; Huyghe, Aurélia et al

in Cell Death & Differentiation (in press)

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See detailA push–pull strategy to control aphids combines intercropping with semiochemical releases
Xu, Qingxuan ULg; Hatt, Séverin ULg; Chevalier Mendes Lopes, Thomas ULg et al

in Journal of Pest Science (in press)

Even if insect pest populations can be reduced by increasing plant diversity through intercropping, natural enemies are not always favored in such systems. Alternatively, semiochemical substances have ... [more ▼]

Even if insect pest populations can be reduced by increasing plant diversity through intercropping, natural enemies are not always favored in such systems. Alternatively, semiochemical substances have been tested to enhance biological control, with inconsistent results. Combining both strategies can be an interesting way to maximize pest control. In this work, a 2-year setup involving wheat–pea strip intercropping combined with the release of E-b-farnesene (EBF) or methyl salicylate (MeSA) was tested as a push–pull strategy to simultaneously repel aphids and attract beneficials. Two types of slow-release formulation (i.e., oil and alginate beads) containing EBF or MeSA were deployed with the intercropping. The abundance of aphids was significantly decreased, while hoverfly larvae and mummified aphids increased on both pea plants and wheat tillers by the release of oil-formulated EBF and MeSA. The proportion parasitism of the aphid-parasitism rate [mummies/(aphids + mummies)] was also increased by treating both crops in both years. Releasing EBF through oil rather than alginate beads proved significantly better for attracting natural enemies and reducing aphids. Aphids were negatively correlated with the density of hoverflies (both adults and larvae) and numbers of mummies. All these results showed that combining intercropping with the release of EBF or MeSA formulated in oil can significantly reduce aphid density and attract their natural enemies. Therefore, the combination of both strategies could help farmers reduce the use of insecticides. [less ▲]

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See detailPharmacokinetic characterization of [18F]UCB-H PET radiopharmaceutical in the rat brain.
Becker, Guillaume ULg; Warnier, Corentin; Serrano Navacerrada, Maria Elisa ULg et al

in Molecular Pharmaceutics (in press)

The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with ... [more ▼]

The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with positron emission tomography (PET), allows the assessment of synaptic density in the living brain. The first-in-class fluorinated SV2A specific radioligand, [18F]UCB-H, is now available at high-activity through an efficient radiosynthesis compliant with the current good manufacturing practices (cGMP). We report here a non-invasive method to quantify [18F]UCB-H binding in rat brain with microPET. Validation study in rats confirmed the need of high enantiomeric purity to target SV2A in vivo. We demonstrated the reliability of a population-based input function to quantify SV2A in preclinical microPET setting. Finally, we investigated the in vivo metabolism of [18F]UCB-H and confirmed the negligible amount of radiometabolites in the rat brain. Hence, the in vivo quantification of SV2A using [18F]UCB-H microPET seems a promising tool for the assessment of the synaptic density in the rat brain, and opens the way for longitudinal follow-up in neurodegenerative diseases rodents’ models. [less ▲]

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See detailIncreased antimicrobial resistance in a novel CMY-54 AmpC-type enzyme with a GluLeu217-218 insertion in the Ω-loop
Pérez-Llarena, Francisco José; Vázquez-Ucha, Juan Carlos; Kerff, Frédéric ULg et al

in Microbial Drug Resistance : Mechanism, Epidemiology, & Disease (in press)

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See detailMaximum energy dissipation to explain velocity fields in shallow reservoirs
Westhoff, Martijn; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Research (in press)

Shallow reservoirs are often used as sediment traps or storage basins, in which sedimentation depends on the flow pattern: Short rectangular reservoirs reveal a straight jet from inlet to outlet with on ... [more ▼]

Shallow reservoirs are often used as sediment traps or storage basins, in which sedimentation depends on the flow pattern: Short rectangular reservoirs reveal a straight jet from inlet to outlet with on both sides identical recirculation zones. In longer reservoirs, the main jet reattaches to the side of the reservoir leading to a small and a large recirculation zone. Previous studies found an empirical geometric relation describing the switch between these two flow patterns. In this study, we demonstrate, with a simple analytical model, that this switch coincides with a maximization of energy dissipation in the shear layer between the main jet and recirculation zones: Short reservoirs dissipate more energy when the flow pattern is symmetric, while longer reservoirs dissipate more energy with an asymmetric pattern. This approach enables to predict the flow patterns without detailed knowledge of small scale processes, potentially useful in the early phase of reservoir design. [less ▲]

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See detailDual action of neuro-estrogens in the regulation of male sexual behavior
Cornil, Charlotte ULg; de Bournonville, Catherine

in General and Comparative Endocrinology (in press)

Estrogens derived from brain testosterone aromatization (neuro-estrogens) are critical for the activation of male sexual behavior. Their effects on this behavior are typically associated with long-term ... [more ▼]

Estrogens derived from brain testosterone aromatization (neuro-estrogens) are critical for the activation of male sexual behavior. Their effects on this behavior are typically associated with long-term changes in circulating levels of testosterone and the transcriptional activity of their liganded nuclear receptors. According to this view, neuro-estrogens would prime the neural circuits controlling the long-term expression of behavior, which would then be acutely regulated by neurotransmitter systems conveying information from the social environment. In parallel, neuro-estrogens are also able to produce much faster effects than previously anticipated. Our recent investigations in Japanese quail revealed an interesting dichotomy in the regulation of male sexual behavior by membrane- and nuclear-initiated estrogen signaling providing respectively an acute modulation of sexual motivation and a long-term control of the capacity to display the copulatory sequence. In parallel, a similar dichotomy applies to the regulation of brain aromatase whose expression depends on the transcriptional activity of testosterone metabolites while its enzymatic activity is rapidly regulated in a region- and context-dependent manner. Recent evidences suggest that rapid changes in sexual motivation result from rapid changes in local estrogen production. Together, these data support the idea that the acute regulation of some aspects of male sexual behavior depends not only on classical neurotransmitter systems, but also on rapid and spatially restricted changes in local estrogen availability. The existing literature suggests that this acute regulation by neuro-estrogens of the motivational aspects of behavior could be generalized to other systems such as singing behavior in songbirds. [less ▲]

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See detailCritical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field
Cailletaud, Johan ULg; De Bleye, Charlotte ULg; Dumont, Elodie ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (in press)

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is ... [more ▼]

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is more sensitive allowing its use for the detection and the quantification of low-dose substances contained in pharmaceutical samples. However, the analytical performance of SERS is limited due to the difficulty to implement a quantitative methodology correctly validated. Nevertheless, some studies reported the development of SERS quantitative methods especially in pharmaceutical approaches. In this context, this review presents the main concepts of the SERS technique. The different steps that need to be applied to develop a SERS quantitative method are also deeply described. The last part of the present manuscript gives a critical overview of the different SERS pharmaceutical applications that were developed for a non-exhaustive list of pharmaceutical compounds with the aim to highlights the validation criteria for each application. [less ▲]

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See detailSerum Creatinine: Not So Simple!
DELANAYE, Pierre ULg; Cavalier, Etienne ULg; Pottel, Hans

in Nephron (in press)

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological ... [more ▼]

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDMS traceability), analytical interferences, analytical coefficient of variation (CV), biological CV and critical difference. Because the relationship between serum creatinine and glomerular filtration rate is hyperbolic, all these CVs will impact not only the precision of serum creatinine but still more the precision of different creatinine-based equations, especially in low or normal-low creatinine levels (or high or normal-high glomerular filtration rate range). [less ▲]

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See detailLe pouvoir judiciaire et l'équilibre des pouvoirs : réflexions à propos des récentes réformes
Bouhon, Frédéric ULg; Pironnet, Quentin ULg

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (in press)

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See detailL'(ir)responsabilité du pouvoir judiciaire : fondement et mise à l'épreuve de l'immunité judiciaire en droits québécois et belge
Bouhon, Frédéric ULg; Lacroix, Mariève

in Revue de Droit International et de Droit Comparé (in press), 2017/3

Ce long article compare les régimes juridiques belge et québécois sur la question de la responsabilité civile pour les fautes commises par les juges dans l'exercice du pouvoir judiciaire. Bien que les ... [more ▼]

Ce long article compare les régimes juridiques belge et québécois sur la question de la responsabilité civile pour les fautes commises par les juges dans l'exercice du pouvoir judiciaire. Bien que les solutions retenues de part et d’autre de l’Atlantique semblent divergentes a priori – absolutisme de l’immunité du juge au Québec et relativisation de celle-ci en Belgique –, un examen plus approfondi révèle que les incidences pratiques ne sont pas aussi radicalement opposées. Certes, l’État belge peut engager sa responsabilité civile en présence d’une faute du juge, ce qui ne saurait être admis au Québec , mais les modalités de l’action civile que la jurisprudence belge a retenues (spécialement la condition de recevabilité et la notion de faute caractérisée) limitent fortement l’ampleur du contentieux dans ce domaine. Par ailleurs, au Québec, on relève un infléchissement – purement théorique, car aucun cas concret où la responsabilité civile du juge a été retenue n’existe à l’heure actuelle – du principe de l’immunité absolue du juge dans le cadre de sa responsabilité civile personnelle, lorsqu’il agit sans compétence, tout en sachant ne pas avoir compétence d’agir ainsi. [less ▲]

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See detailEvaluation of the spatial and economic effectiveness of industrial land policies in Northwest Europe
Vandermeer, Marie-Caroline; Halleux, Jean-Marie ULg

in European Planning Studies (in press)

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e ... [more ▼]

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e. that industrial land policy plays a key role in the creation of growth and new jobs. The article begins with a reflection on the literature, which stresses the need to develop knowledge on industrial land policies. To help fill this research gap, we have developed an exploratory piece of research on the theme of their spatial and economic effectiveness, on the basis of statistical analyses dedicated to seven countries. As regards spatial effectiveness, the results underline significant national differentials in terms of land consumption on the one hand, while highlighting the economic sprawl that affects France and Belgium on the other hand. As regards economic effectiveness, our results show that the impact of the development of economic estates on growth depends largely on regional contexts. In particular, the “intermediate regions” in western Germany stand out as belonging to a specific context where land policies seem particularly effective from an economic standpoint. By contrast, the economic effectiveness of industrial land policies requires readjustments in most “predominantly rural regions, close to a city”. [less ▲]

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See detailDemeter's Arrival at Eleusis on an Apulian Oinochoe kept in Foggia
Cuvelier, Graham ULg

in Babesch : Bulletin Antieke Beschaving (in press)

This article offers an interpretation of the scene depicted on the body of an Apulian red-figured oinochoe, assigned to the Darius Painter, now kept in the storage of the Museo Civico of Foggia. This ... [more ▼]

This article offers an interpretation of the scene depicted on the body of an Apulian red-figured oinochoe, assigned to the Darius Painter, now kept in the storage of the Museo Civico of Foggia. This interpretation is based on the analysis of the iconographic language of the Apulian imagery as well as on the connexion in series of this scene with those appearing on contemporary vases produced in the same cultural community. This article is also accompanied by a set of previously unpublished colour pictures (of the entire vase and of several details) taken on site by the author. [less ▲]

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See detailMusique et culture à Rome et dans l’Italie méridionale entre Renaissance et Baroque
Morales, Jorge ULg

in Le jardin de musique (in press), X

Alfred Einstein soulignait en 1949 qu’« à Naples comme à Palerme, le baroque le plus extravagant fleurissait à l’église, à la cour et dans la musique ». En effet, la culture de la Méditerranée – ... [more ▼]

Alfred Einstein soulignait en 1949 qu’« à Naples comme à Palerme, le baroque le plus extravagant fleurissait à l’église, à la cour et dans la musique ». En effet, la culture de la Méditerranée – immémorial carrefour de nombreuses civilisations – a donné naissance à un monde musical riche et singulier dans la période qui court de la fin de la Renaissance au début du Baroque et sur lequel il reste beaucoup à découvrir. Il en est de même pour Rome : la richesse de l’activité musicale s’y présentait sous les formes les plus éclectiques. La Ville Eternelle était alors en effet la cour la plus importante de la Péninsule, foyer culturel majeur et porte de l’Italie méridionale. Nous pouvons constater un récent regain d’intérêt pour la recherche archivistique et historique qui a permis, à travers de nombreux travaux et colloques, de jeter un regard neuf sur le milieu musical et culturel romain et méditerranéen de cette époque (musique vocale profane et sacrée, musique instrumentale, théâtre, institutions musicales, etc.). Ces travaux jettent les fondements d’une recherche qui ne demande qu’à être approfondie. [less ▲]

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See detailCrystal Structure and Kinetic Analysis of the Class B3 Di-Zinc Metallo-β-Lactamase LRA-12 from an Alaskan Soil Metagenome
Rodríguez, María Margarita; Herman, Raphaël ULg; Ghiglione, Barbara et al

in PLoS ONE (in press)

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See detailSpatiotemporal variation of drought characteristics in the context of climate change in the Huang-Huai-Hai Plain, China
Li, Xiang-Xiang; Ju, Hui; Garré, Sarah ULg et al

in Journal of Integrative Agriculture (in press)

Understanding the potential drought characteristics under climate change is essential for reducing vulnerability and establishing adaptation strategies, especially in the Huang-Huai-Hai Plain (3H Plain ... [more ▼]

Understanding the potential drought characteristics under climate change is essential for reducing vulnerability and establishing adaptation strategies, especially in the Huang-Huai-Hai Plain (3H Plain) which is the grain production base in China. In this paper, the variation of drought characteristics including drought event frequency, duration, severity and intensity for the past 50 years (1961-2010) and future scenarios (2010-2099) based on observed meteorological data and RCP 8.5 projections were investigated, respectively. Firstly, the applicability of three climatic drought indices including the Standardized Precipitation Index (SPI), the Standardized Precipitation Evapotranspiration Index based on the Penman–Monteith equation (SPEI-PM) and the Thornthwaite equation (SPEI-TH) were compared in tracing recorded agricultural drought areas. Then, the drought characteristics including drought event, duration, severity and intensity using “run theory” was analyzed for both historical observations and future RCP 8.5 scenarios based on the proper index. Correlation analysis between drought indexes and agricultural drought areas showed that SPEI-PM performed better than SPI and SPEI-TH in the 3H Plain. Based on the results of SPEI-PM, droughts over the past 50 years have experienced reduced drought with shorter durations, and weaker severity and intensity. However, for the future RCP 8.5 scenario, drought is predicted to rise in frequency, duration, severity and intensity from 2010-2099 although drought components during the 2010-2039 were milder compared to historical conditions. This study highlights that the estimations for atmospheric evaporative demand would bring in differences in long term drought trend of drought indexes and consequently the applicability in 3H Plain. The results of this paper can help inform researchers and local policy makers to establish drought risk management strategies. [less ▲]

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See detailMultivariate analysis of 18F-DMFP PET data to assist the diagnosis of parkinsonism
Segovia, Fermin; Gorriz, Juan M.; Ramirez, Javier et al

in Frontiers in Neuroinformatics (in press)

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