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See detailCircadian and circannual variations in cord blood hematopoietic cell composition
Servais, Sophie ULg; BAUDOUX, Etienne ULg; Brichard, B. et al

in Haematologica (in press)

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See detailArsinoe II come dea attraverso le sue epiclesi cultuali
Caneva, Stefano ULg

in Athenaeum : Studii Periodici di Letteratura e Storia (in press)

Dopo una introduzione storica e storiografica sul significato dei culti regali ellenistici, l’intervento esamina alcuni dei nomi divini attribuiti ad Arsinoe II nelle fonti letterarie e documentarie, con ... [more ▼]

Dopo una introduzione storica e storiografica sul significato dei culti regali ellenistici, l’intervento esamina alcuni dei nomi divini attribuiti ad Arsinoe II nelle fonti letterarie e documentarie, con l’eccezione dell’epiclesi esclusiva Philadelphos. Scopo della ricerca è 1) una valutazione delle strategie di inserimento della nuova dea nel pantheon tradizionale; 2) una riflessione sull’autoconsapevolezza degli antichi in relazione alla propria tradizione religiosa, per come essa si manifesta attraverso l’oculata manipolazione di un elemento essenziale nella definizione della divinità, qual è il nome divino. Un’Appendice elenca, in tre tabelle, tutte le denominazioni greche di Arsinoe II (esclusa Philadelphos), fornendo indicazioni sulla fonte, la sua collocazione spaziale e temporale e sulla divinità tradizionale di riferimento. [less ▲]

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See detailArrêts sur images – usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un ... [more ▼]

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un défilement réglé (24 photogrammes/seconde) par le dispositif technique du cinéma. Image paradoxale en ce qu’elle reste invisible au spectateur malgré sa force iconique, le photogramme trouve cependant, dans le flux qui le conduit insensiblement à la disparition, certaines zones de visibilité qui en révèlent le caractère à la fois fragile et intensif. Nous allons donc envisager certaines pratiques ou certains usages du photogramme cinématographique, tout en essayant de dégager, au départ de ces pratiques, les éléments d’une théorie du photogramme, que Roland Barthes et Sylvie Pierre appelaient déjà de leurs vœux. Des protos-photogrammes et de leur usage scientifique chez Muybridge et Marey, aux usages artistiques contemporains, en passant par des pratiques publicitaires, promotionnelles ou analytiques, nous allons voir que le photogramme reste un objet singulier. [less ▲]

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See detailAtomistic account of structural and dynamical changes induced by small binders in the double helix of a short DNA
Fresch, Barbara ULg; Remacle, Françoise ULg

in Physical Chemistry Chemical Physics [=PCCP] (in press)

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See detailSur Capitalisme, désir et servitude. Lettre à Frédéric Lordon
Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailPIXE identification of the provenance of ferruginous rocks used by Neanderthals
Mathis, François ULg; Bodu, Pierre; Dubreuil, Olivier ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (in press)

Les Bossats, near Ormesson, France, is a newly discovered late Mousterian open air site dated to around 47,000 years ago by thermoluminescence. The archaeological level, fossilized by loess, revealed a ... [more ▼]

Les Bossats, near Ormesson, France, is a newly discovered late Mousterian open air site dated to around 47,000 years ago by thermoluminescence. The archaeological level, fossilized by loess, revealed a rich industry based on the discoid mode, associated with numerous fragments of red and yellow iron oxide-rich rocks showing clear traces of powder production (abrasion, striation, scraping), which are exceptional remains for this remote period. Archeological material and geological samples from the close environment were studied by PIXE and by petrographical observations made on thin sections. The geological sources were identified by means of PIXE analyses on two IBA facilities: AGLAE (2 MV tandem) at the C2RMF in Paris and the cyclotron of the IPNAS (University of Liège). We paid particular attention to the comparison of results obtained on both installations by using the same set of geological standards and by a fine evaluation of the limit of detection relative to each trace elements of interest for both experimental set ups. The elemental fingerprint of one geological source of iron-rich concretions corresponds clearly with the archaeological collection. At least, this investigation demonstrates that the colouring materials were minutely selected in the close neighbouring of the site by the Neanderthals. [less ▲]

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See detailEffect of bovine colostrum intake on growth, reproductive parameters and survival in red kids
Harouna, Abdou; Marichatou, Hamani; Beckers, Jean-François ULg et al

in Journal of Animal Physiology & Animal Nutrition (in press)

The aim of this study is to evaluate the efficacy of frozen Azawak colostrum supplementation on body weight (BW), average daily gain (ADG), reproductive parameters (mean age at first parturition ... [more ▼]

The aim of this study is to evaluate the efficacy of frozen Azawak colostrum supplementation on body weight (BW), average daily gain (ADG), reproductive parameters (mean age at first parturition, fertility, fecundity, prolificacy) and mortality rate among red kids. The study was conducted at the goat farm secondary centre of Maradi in Niger from September 2010 to September 2011. The control animals (n = 20) were left with their mother, while the treatment animals (n = 20) received in addition 50 ml/animal/day of bovine colostrum at birth and 15 ml/animal/day from d2 to d15. Weight was measured weekly from birth to d365. Mortalities were also recorded over the same period. For reproductive parameters, observations began at weaning (d197). Growth rate was higher (p < 0.001) in supplemented animal, and the treatment effects on ADG were observed up to 150 day after the end of supplementation. A similar long-lasting trend was also observed in relation to the mortality rate (25% for ColG vs. 55% for ConG; p = 0.05). The age at first kidding tended to be lower in the treated group (13.8 0.7 vs. 14.1 0.8 month; p < 0.1). In conclusion, mild bovine colostrum supplementation induces a long-lasting positive impact on growth rate and to a lower extent on reproduction parameters and survival rate. [less ▲]

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See detailA Double-Blind, Placebo Controlled, Randomized Trial to Assess the Impact of a Monthly Administration of 50,000 IU of Vitamin D3 for 6 Months on Serum Levels of 25-Hydroxyvitamin D in Healthy Young Adults
Brunel, Elodie ULg; SCHNITZLER, Maryline ULg; Foidart-Dessalle, Marguerite ULg et al

in International Journal of Endocrinology (in press)

In this double blind, unicentre, randomized, placebo controlled study, we evaluated the changes in 25-hydroxyvitamin D (25(OH)D) serum levels in 150 young Belgian adults (18–30 years), monthly ... [more ▼]

In this double blind, unicentre, randomized, placebo controlled study, we evaluated the changes in 25-hydroxyvitamin D (25(OH)D) serum levels in 150 young Belgian adults (18–30 years), monthly supplemented with 50,000 IU of vitamin D (VTD) or placebo for 6 months, from November 2010 to May 2011. At T0, 30% of the population presented 25(OH)D serum levels below 20 ng/mL. In the VTD-treated group, mean serum levels increased from 21.2 ± 8.2 to 30.6 ± 8.8 ng/mL (𝑃 < 0.001) at T3mo and to 36.0 ± 9.2 ng/mL (𝑃 < 0.001) at T6mo. Despite documented VTD intake, no changes in serum levels were, however, observed in 10% of the treated group. In the placebo group, mean 25(OH)D serum levels decreased from22.8 ± 8.5 to 14.0 ± 6.9 ng/mL at T3mo (𝑃 < 0.001) but returned to values not significantly different from those observed at T0 (23.5 ± 8.6 ng/mL) at T6mo. No difference between serum calcium levels was observed between the groups throughout the study. In conclusion, monthly supplementation with50,000UIofVTDinwinter canwarrant serum25(OH)Dlevels above 20ng/mL in96.2%of thosehealthy young adultswithout inducing unacceptably high 25(OH)D concentration. This supplementation is safe andmay be proposed without 25(OH)D testing. [less ▲]

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See detailLa maladie de Lyme entre cadrage infectieux, vectoriel et zoonotique : vers une écologisation des problèmes sanitaires
Massart, Clémence

in VertigO : la Revue Electronique en Sciences de l'Environnement (in press)

This paper is devoted to the qualification of Lyme disease in France. Firt vectorial disease in the northern hemisphere, Lyme diseas is transmitted by a genus of tick called Ixodes (in Europe by Ixodes ... [more ▼]

This paper is devoted to the qualification of Lyme disease in France. Firt vectorial disease in the northern hemisphere, Lyme diseas is transmitted by a genus of tick called Ixodes (in Europe by Ixodes ricinus ; in Asia by Ixodes persulcatus ; in United States and in Canada by Ixodes scapularis). Concerned only with human health and limited to Lyme, a first framing has grown around physicians and patients which are involved in a controversy. Progressively, a second framing has emerged, called vectorial and structured around ecologists, normally not involved in human health. Based on the vector, this framing includes other diseases transmitted by Ixodes ricinus which, during the last 30 years, have been discovered : Tick-Borne Encephalitis, Babesia divergens, Bartonella infection, Tularemia, etc. Linked to these new pathologies, the media coverage of Lyme has finally opened the « vectorial transmission category » – usually associated to mosquitoes and south countries – to ticks and diseases from the north. A third framing dedicated to animal reservoir and called zoonotic is emerging at last. We can see in that framing overlapping a kind of “ecologization” of sanitary issues. [less ▲]

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See detailAIR VERSUS GROUND TRANSPORT OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: EXPERIENCE IN A RURAL-BASED HELICOPTER MEDICAL SERVICE
MOENS, Didier ULg; Stipulante, Samuel ULg; Donneau, Anne-Françoise ULg et al

in European Journal of Emergency Medicine (in press)

Aims Primary pre-hospital Helicopter Emergency Medical Service (HEMS) interventions may play a role in timely reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI). We ... [more ▼]

Aims Primary pre-hospital Helicopter Emergency Medical Service (HEMS) interventions may play a role in timely reperfusion therapy for patients with ST-segment elevation myocardial infarction (STEMI). We designed a prospective study involving patients with acute myocardial infarction aimed at the evaluation of the potential benefit of such primary HEMS interventions as compared with classical EMS ground transport. Methods & results This prospective study was conducted from July 1, 2007 to June 15, 2012. Successive patients with ST-segment elevation myocardial infarction (STEMI) eligible for percutaneous coronary intervention (PCI) were included. Simulated ground-based access times were computed using a digital cartographic program, allowing the estimation of healthcare system delay from call to admission to the catheterisation laboratory. During the study period, 4485 patients benefited from HEMS activations. Of these patients, 342 (8%) suffering from STEMI were transferred for primary PCI. Median primary response time time was 11 min (IQR: 8 - 14 min) using the helicopter and 32 min (25 – 44 min) using road transport. Median transport time using HEMS was 12 min (9 – 15 min) and 50 min (36 – 56 min) by road. The median system delay using HEMS was 52 min (45 – 60 min), while this time was 110 min (95 – 126 min) by road. Finally, the system delay median gain was 60 min (47 – 72 min). Conclusions Using HEMS in a rural region allows STEMI patients to benefit from appropriate rescue care with similar delays as those seen in urban patients. [less ▲]

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See detailComposantes métacognitives ; Définitions et outils d’évaluation
Frenkel, Stéphanie ULg

in Enfance : Psychologie, Pédagogie, Neuropsychiatrie, Sociologie (in press)

Many tools have been developed since the 1970s in order to assess metacognition and its first implementations. Over time, questionnaires, tests, interviews, observations, computer programmes, and other ... [more ▼]

Many tools have been developed since the 1970s in order to assess metacognition and its first implementations. Over time, questionnaires, tests, interviews, observations, computer programmes, and other methods have become more and more based on self-regulated learning theories. At the same time, for the last fifteen years or so, the number of students with learning difficulties linked to the way they learn seems to be increasing slowly but steadily. Therefore, it seems essential to enable these learners develop a more efficient learning behaviour. Similarly, we see that professional field workers are increasingly asking for efficient and adapted tools in this field. The purpose of this paper is twofold: it provides a review of the above-mentioned assessment tools, and it discusses them in order to contribute to the creation of new tools with a wider scope. Following an analysis of the abundant literature on the subject, two classifications were developed. Thirty-five tools were kept and categorised: first, according to a developmental perspective (preschool, primary school, secondary school and/or adult), second, according to the metacognitive component they assess (metacognitive knowledge, strategies and/or experiences). However, no existing tool covers the whole period of compulsory education. Moreover, in order to assess the learners’ metacognitive abilities fully, it is necessary to combine online and offline assessments in concrete situations. There are still some needs to be met in this regard. [less ▲]

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See detailMultiscale modelling framework for the fracture of thin brittle polycrystalline films - Application to polysilicon
Mulay, Shantanu; Becker, Gauthier ULg; Vayrette, Renaud et al

in Computational Mechanics (in press)

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability ... [more ▼]

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability. The effect of the orientation of grains on the fracture behaviour of polycrystalline silicon is investigated out of the several factors. This is achieved, firstly, by identifying the statistical variation of the fracture strength and critical strain energy release rate, at the nanoscopic scale, over a thin freestanding polycrystalline silicon film, having mesoscopic scale dimensions. The fracture stress and strain at the mesoscopic level are found to be closely matching with uniaxial tension experimental results. Secondly, the polycrystalline silicon film is considered at the continuum MEMS scale, and its fracture behaviour is studied by incorporating the nanoscopic scale effect of grain orientation. The entire modelling and simulation of the thin film is achieved by combining the discontinuous Galerkin method and extrinsic cohesive law describing the fracture process. [less ▲]

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See detailThe Sceptical President: Václav Klaus' Influence on Czech Public Opinion on Climate Change
De Pryck, Kari; Gemenne, François ULg

in Climatic Change (in press)

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See detailA review of inversion techniques related to the use of relationship matrices in animal breeding
Faux, Pierre ULg; Gengler, Nicolas ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

In animal breeding, prediction of genetic effects is usually obtained through the use of mixed models. For any of these genetic effects, mixed models require the inversion of the covariance matrix ... [more ▼]

In animal breeding, prediction of genetic effects is usually obtained through the use of mixed models. For any of these genetic effects, mixed models require the inversion of the covariance matrix associated to that effect, which is equal to the associated relationship matrix times the associated component of the genetic variance. Given the size of many genetic evaluation systems, computing the inverses of these relationship matrices is not trivial. In this review, we aim to cover computational techniques that ease inversion of relationship matrices used in animal breeding for prediction of the following different types of genetic effects: additive effect, gametic effect, effect due to presence of marked quantitative trait loci, dominance effect and different epistasis effects. Construction rules and inversion algorithms are detailed for each relationship matrix. In the final discussion, we draw up a common theoretical frame to most of the reviewed techniques. Two computational constraints come out of this theoretical frame: setting up the matrix of dependencies between levels of the effect and setting up some parts (diagonal or block-diagonal elements) of the relationship matrix to be inverted. [less ▲]

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See detailJatropha curcas L. (Euphorbiaceae): Insectes ravageurs et propriétés biocides
Abdoul Habou, Zakari; Toudou, Adam; Haubruge, Eric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Jatropha curcas, ou Pourghère, est un arbuste de la famille des Euphorbiacées, largement répandu dans les pays tropicaux. Ses graines sont riches d'une huile pouvant servir de biocarburant dans les ... [more ▼]

Jatropha curcas, ou Pourghère, est un arbuste de la famille des Euphorbiacées, largement répandu dans les pays tropicaux. Ses graines sont riches d'une huile pouvant servir de biocarburant dans les moteurs diesels modifiés. La plante est attaquée par divers insectes ravageurs appartenant principalement aux ordres des Hétéroptères, Coléoptères et Orthoptères. Ils provoquent des dégâts sur les fruits, les inflorescences et les feuilles. Les ravageurs les plus fréquemment observés sur J. curcas sont des punaises du genre Pachycoris (Hétéroptère : Scutelleridae), qui sont largement répandues au Mexique, en Australie, aux États-Unis, au Brésil et au Nicaragua. Ces punaises causent des dégâts importants sur les fruits et provoquent la malformation des graines, et avec elle une réduction de la teneur en huile. Même si les arbustes de Jatropha sont victime d'infestations d'insectes, plusieurs études démontrent l'effet insecticide de son huile contre des ravageurs importants tels que Busseola fusca (Fuller) (Lépidoptère : Noctuidae), Sesamia calamistis Hampson (Lépidoptère : Noctuidae), Aphis gossypii Glover (Homoptère: Aphididae) et Callosobruchus chinensis L. (Coléoptère : Bruchidae). Dans ce document, nous présentons dans une première partie les principaux insectes ravageurs de J. curcas et dans une seconde section les effets insecticides démontrés de son huile. [less ▲]

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See detailÉtude des contraintes mécaniques locomotrices chez le cheval
Noble, Prisca ULg; Collin, Bernard ULg; Denoix, Jean-Marie et al

in Annales de Médecine Vétérinaire (in press)

In locomotor biomechanics, three high groups of contraints are commonly encountared : pressure, traction and torsion. In supra-maximal conditions, all of these contraints would be responsible of some ... [more ▼]

In locomotor biomechanics, three high groups of contraints are commonly encountared : pressure, traction and torsion. In supra-maximal conditions, all of these contraints would be responsible of some equine diseased locomotor systems. In order to understand better the contraints in the equine locomotor dynamics, some investigations have been carried out. Moreover, some measurement methods, based on the mechanics of Newton, have been performed. This review shows the different measurement techniques and introduces the mechanical basis that are compulsory for the understanding of the equine locomotor apparatus functioning. [less ▲]

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See detailSouthern Ocean CO2 sink: The contribution of the sea ice
Delille, Bruno ULg; Vancoppenolle, M; Geilfus, N.-X. et al

in Journal of Geophysical Research. Oceans (in press)

We report first direct measurements of the partial pressure of CO2 (pCO2) within Antarctic pack sea ice brines and related CO2 fluxes across the air-ice interface. From late winter to summer, brines ... [more ▼]

We report first direct measurements of the partial pressure of CO2 (pCO2) within Antarctic pack sea ice brines and related CO2 fluxes across the air-ice interface. From late winter to summer, brines encased in the ice change from a CO2 large over-saturation, relative to the atmosphere, to a marked under-saturation while the underlying oceanic waters remains slightly oversaturated. The decrease from winter to summer of pCO2 in the brines is driven by dilution with melting ice, dissolution of carbonate minerals crystals and net primary production. As the ice warms, its permeability increases, allowing CO2 transfer at the air-sea ice interface. The sea ice changes from a transient source to a sink for atmospheric CO2. We upscale these observations to the whole Antarctic sea-icesea ice cover using the NEMO-LIM3 large-scale sea ice-ocean, and provide first estimates of spring and summer CO2 uptake from the atmosphere by Antarctic sea ice. Over the spring-summer period, the Antarctic sea-icesea ice cover is a net sink of atmospheric CO2 of 0.029 PgC, about 58% of the estimated annual uptake from the Southern Ocean. Sea ice then contributes significantly to the sink of CO2 of the Southern Ocean. [less ▲]

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See detailGenetic parameters for mid-infrared methane indicators based on milk fatty acids in dairy cows
Kandel, Purna Bhadra ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Journal of Applied Animal Research (in press)

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not ... [more ▼]

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not currently available. The mid-infrared (MIR) prediction of milk fatty acids is relevant in this context. Five MIR methane indicators were derived from the literature and were calibrated from 600 samples analyzed by gas chromatography. Genetic parameters for these traits were estimated using single trait random regression test-day models from 619,265 records collected from 2007 to 2011 on 71,188 Holstein cows in their first three lactations. For the published indicator showing the highest relationship with the methane data (R2 = 0.88), the average daily heritability was 0.34±0.01, 0.37±0.01 and 0.34±0.01 for the first three lactations, respectively. The methane emission (g/day) was increased from beginning of lactation, reached at the highest in peak of lactation and decreased towards end of lactation. The largest differences between estimated breeding values (EBV) of sires having daughters in production eructing the highest and the lowest methane content was 21.80, 22.75 and 24.89 kg per lactation for the first three parities. Positive genetic correlations were estimated between indicator traits and milk fat and protein content. Low negative correlation was observed with milk yield. In conclusion, this study shows the feasibility to predict methane indicator traits by MIR. Moreover, the estimated genetic parameters suggest also a potential genetic variability of the quantity of methane eructed by dairy cows. [less ▲]

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See detailCorporate Disclosures, Information Asymmetry and Stock-Market Liquidity in France
Sougné, Danielle ULg; Ajina, Aymen; Lakhal, Faten

in Journal of Applied Business Research (in press)

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of ... [more ▼]

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of information included in the annual reports on investor’s behavior. This is proxied by the information asymmetry component of the bid-ask spread and stock market liquidity. Our sample includes 196 French listed firms over a period ranging from 2004 to 2007. We opt for an explanatory study using OLS regressions to examine the nature of the relationship between information disclosed in annual reports and bid-ask spreads a proxy for information asymmetry and stock market liquidity. The results show that the extent of corporate disclosures in annual reports positively influences the liquidity of the French market and negatively affects the adverse selection component of the bid-ask spread. This effect is further confirmed by the commitment to IFRS by French-listed firms from 2005. The decomposition of the total score in the sub-indices shows that non-financial and financial information are important in trading decisions while strategic information may be attractive only for long-term positions [less ▲]

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See detailSome misunderstood or unknown tricks (XI) (LaTeX) and encoding issues (II)
Merciadri, Luca ULg

in TUGboat (in press)

Three subjects will be detailed: 1. Using LaTeX syntax as an unambiguous way to communicate, 2. Writing a bold \ell, 3. Fonts' encodings.

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See detailUne tablette scolaire copte de Lecce : TUL inv. C 1
Carlig, Nathan ULg; Delattre, Alain

in Studi di Egittologia e di Papirologia (in press)

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See detailSome misunderstood or unknown tricks (XIII) (LaTeX)
Merciadri, Luca ULg

in TUGboat (in press)

We will here again consider many tips and tricks. This time, they will mostly come from Glad Deschrijver, TeX Tricks, 2011. (http://users.ugent.be/~gdschrij/LaTeX/textricks.html.) Tricks: vertically ... [more ▼]

We will here again consider many tips and tricks. This time, they will mostly come from Glad Deschrijver, TeX Tricks, 2011. (http://users.ugent.be/~gdschrij/LaTeX/textricks.html.) Tricks: vertically aligned itemize environments, allowing linebreaks after comma in math mode, writing under and over elements, and using stacks, footnotes with a new number at each section, footnotes in tabular, splitting algorithm environments on multiple pages, let " produce opening/closing quotation marks, indenting some text but not the first line, using diagonal dots positioned according to the opposite diagonal, using a centered verbatim environment, drawing a table with dashed lines, shaded cells and arrows pointing at a row and a column, correct spacing around square brackets (used for sets) in math mode. [less ▲]

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See detailDabigatran Etexilate and Risk of Myocardial Infarction, Other Cardiovascular Events, Major Bleeding, and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Douxfils, Jonathan; Buckinx, Fanny ULg; Mullier, Francois et al

in Journal of the American Heart Association (in press)

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of ... [more ▼]

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of the published literature and a clinical trials registry maintained by the drug manufacturer. Criteria for inclusion in our meta-analysis included all RCTs and the availability of outcome data for MI, other cardiovascular events, major bleeding, and all-cause mortality. Among the 501 unique references identified, 14 RCTs fulfilled the inclusion criteria. Stratification analyses by comparators and doses of dabigatran etexilate were conducted. Peto odds ratio (ORPETO) values using the fixed-effect model (FEM) for MI, other cardiovascular events, major bleeding, and all-cause mortality were 1.34 (95% CI 1.08 to 1.65, P=0.007), 0.93 (95%CI 0.83 to 1.06, P=0.270), 0.88 (95% CI 0.79 to 0.99, P=0.029), and 0.89 (95% CI 0.80 to 1.00, P=0.041). When compared with warfarin, ORPETO values using FEM were 1.41 (95% CI 1.11 to 1.80, P=0.005), 0.94 (95%CI 0.83 to 1.06, P=0.293), 0.85 (95% CI 0.76 to 0.96, P=0.007), and 0.90 (95% CI 0.81 to 1.01, P=0.061), respectively. In RCTs using the 150-mg BID dosage, the ORPETO values using FEM were 1.45 (95% CI 1.11 to 1.91, P=0.007), 0.95 (95% CI 0.82 to 1.09, P=0.423), 0.92 (95% CI 0.81 to 1.05, P=0.228), and 0.88 (95% CI 0.78 to 1.00, P=0.045), respectively. The results of the 110-mg BID dosage were mainly driven by the RE-LY trial. CONCLUSIONS: This meta-analysis provides evidence that dabigatran etexilate is associated with a significantly increased risk of MI. This increased risk should be considered taking into account the overall benefit in terms of major bleeding and all-cause mortality. [less ▲]

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See detailCapacitated Vehicle Routing Problem With Sequence Based Pallet Loading and Axle Weight Constraints
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in EURO Journal on Transportation and Logistics (in press)

In this paper, we introduce and study the capacitated vehicle routing problem with sequence based pallet loading and axle weight constraints. To the best of our knowledge, it is the rst time that axle ... [more ▼]

In this paper, we introduce and study the capacitated vehicle routing problem with sequence based pallet loading and axle weight constraints. To the best of our knowledge, it is the rst time that axle weight restrictions are incorporated in a vehicle routing model. The aim of this paper is to demonstrate that incorporating axle weight restrictions in a vehicle routing model is possible and necessary for a feasible route planning. Axle weight limits impose a great challenge for transportation companies. Trucks with overloaded axles represent a signi cant threat for tra c safety and may cause serious damage to the road surface. Transporters face high nes when violating these limits. A mixed integer linear programming formulation for the capacitated vehicle routing problem with sequence based pallet loading and axle weight constraints is provided. Results of the model are compared to results of the model without axle weight restrictions. Computational experiments demonstrate that the model performs adequately and that the integration of axle weight constraints in vehicle routing models is required for a feasible route planning. [less ▲]

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (in press)

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailLa maladie de Lyme entre cadrage infectieux, vectoriel et zoonotique : vers une écologisation des problèmes sanitaires ?
Massart, Clémence ULg

in VertigO : la Revue Electronique en Sciences de l'Environnement (in press)

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ... [more ▼]

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ricinus en Europe ; Ixodes persulcatus en Asie ; Ixodes scapularis aux États-Unis et au Canada). Les médecins et les malades ont d’abord développé un cadrage infectieux, ancré dans la santé humaine, réservé à Lyme et soumis à une vive controverse. Progressivement, un second cadrage vectoriel s’est structuré autour des entomologistes médicaux puis des écologues, généralement étrangers à la problématique des maladies humaines. Axé sur le vecteur, ce cadrage englobe les autres maladies transmises par Ixodes ricinus en Europe qui, durant les 30 dernières années, n’ont cessé d’être découvertes : bartonnelles, babésioses, tularémie, encéphalite à tiques, etc. Combinée à ces nouvelles pathologies, la notoriété de Lyme a finalement contribué à ouvrir la catégorie « transmission vectorielle » – traditionnellement associée aux moustiques des pays tropicaux – aux tiques et aux maladies de l’hémisphère nord qu’elles véhiculent. Un troisième cadrage axé sur les réservoirs et qualifié de zoonotique commence enfin à se dessiner. Il faut reconnaître dans cette juxtaposition des cadrages – infectieux, vectoriel et zoonotique – une forme d’écologisation des problèmes sanitaires. [less ▲]

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See detailIl design come strumento politico e ideologico, tra Firenze e Torino (1965-1975)
Prina, Daniela ULg

in Allegoria (in press), 68(2),

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See detailThe open-air site of Tolbor 16 (Northern Mongolia): preliminary results and perspectives
Zwyns, N.; Gladyshev; Gunchinsuren, B. et al

in Quaternary International (in press)

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See detailIdentification of cardiac repercussions after intense and prolonged concentric isokinetic exercise in young sedentary people.
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Couffignal, Vincent et al

in Clinical physiology and functional imaging (in press)

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among ... [more ▼]

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among those who are unaware of their heart condition. The development of cardiospecific biochemical markers has led to a reconsideration of the role of biology in the diagnosis of cardiovascular illnesses. The aim of this study therefore was, through the use of cardiac biomarker assays, to highlight the impact of sustained physical effort in the form of intense and prolonged concentric isokinetic exercise and to research potential cardiovascular risks. MATERIALS AND METHODS: Eighteen subjects participated in a maximal concentric isokinetic exercise involving 30 knee flexion-extensions for each leg. Five blood tests were taken to study the kinetics of the cardiac biomarkers. Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: The results showed significant increases in the creatine kinase, myoglobin, homocysteine and haemoglobin cardiac markers. Evolutionary trends were also observed for the following biomarkers: NT-proBNP, myeloperoxydase and C-reactive protein. All the physiological parameters measured presented statistically significant changes. CONCLUSION: Isokinetic effort leads to the release of cardiac markers in the blood, but these do not exceed the reference values in healthy subjects. Maximal concentric isokinetic exercise does not, therefore, lead to an increased risk of cardiovascular pathologies. [less ▲]

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See detailChemical composition of colostrum from Azawak cow in Niger compared with meta-analytical data
Abdou, Harouna; Marichatou, Hamani; Beckers, Jean-François ULg et al

in Animal Genetic Resources Information = Bulletin d'Information sur les Ressources Génétiques Animales = Boletin de Informacion sobre Recursos Geneticos Animales (in press)

This study aimed at comparing data obtained from Azawak zebu colostrum with literature data. The comparison was performed by a meta-analytical approach. Colostrum samples were hand-collected after 5 h ... [more ▼]

This study aimed at comparing data obtained from Azawak zebu colostrum with literature data. The comparison was performed by a meta-analytical approach. Colostrum samples were hand-collected after 5 h from 7 Azawak cows at calving between August 27, to September 10, 2009 in the Sahel. For data from literature, twenty one (21) references were identified in the following analytical databases: PubMed, Science Direct, Google scholar, Collection from University of Liege. The references were selected according to the following two criteria: i) only studies reported on bovine colostrum were used irrespective of breeds, and ii) among the selected studies, those not providing complete information to allow meta-analytical calculation were excluded. Samples were analyzed for immunoglobulins (IgG, IgM, IgA), lactoferrin, and chemical composition (dry mater, protein, fat, lactose, ash, Ca, P, NA, K, Mg). The mean levels of IgG, IgM, dry matter, protein and fat for Azawak cows were lower (P ˂ 0.001) than those obtained in other breeds; however colostrum from the Azawak was higher in IgA but the difference was not significant. For lactose and ash, mean values for Azawak cows were higher (P ˂ 0.001) than those from the literature. Contents of Ca, P, Na and Mg in Azawak bovine colostrum were significantly higher (P ˂ 0.001) than the mean levels in form the literature data. In conclusion, the colostrum from Azawak cows appears to be lower in most immunoglobulins, in fat and in protein than the values reported in the literature, but higher in lactose and minerals. This could be an adaptation to sahelian contraints. [less ▲]

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See detailDynamic single-cell analysis of Saccharomyces cerevisiae under process perturbation: comparison of different methods for monitoring the intensity of population heterogeneity
Delvigne, Frank ULg; Baert, Jonathan ULg; Gofflot, Sébastien et al

in Journal of Chemical Technology & Biotechnology (in press)

BACKGROUND: Single cell biology has attracted a lot of attention these past few years and has led to numerous fundamental results pointing out the heterogeneity of clonal cell populations. In this context ... [more ▼]

BACKGROUND: Single cell biology has attracted a lot of attention these past few years and has led to numerous fundamental results pointing out the heterogeneity of clonal cell populations. In this context, microbial phenotypic heterogeneity under bioprocessing conditions needs to be further investigated. In this study, yeast based processes have been investigated by using on-line flow cytometry in combination with a fluorescent transcriptional reporter (GFP) and viability fluorescence tags (propidium iodide, PI). Methods aiming at expressing the dispersion of these fluorescence tags among the yeast populations have been investigated for different bioreactor operating conditions. RESULTS: Yeast viability was determined on the basis of PI uptake. Segregation between PI negative and positive subpopulations could be efficiently quantified on the basis of the mean-to-median ratio or the amplitude of the interquartile range. On the other hand, the same quantification could not be made for the segregation occurring at the level of GFP synthesis. Indeed, when cells were exposed to sub-lethal or mild stresses (such as in scale-down reactors) two GFP subpopulations could be visualized by real-time FC, but quantification by one of the above-mentioned methods was not possible. CONCLUSIONS: Yeast population heterogeneity was observed in representative bioreactor operating conditions. Difficulties for the determination of segregation at the level of GFP synthesis point out the fact that one needs to understand the segregation mechanisms for the applied fluorescent reporters, to judge whether simple mathematical tools may be applied or if more sophisticated computational tools are needed for the quantification of the microbial population segregation. [less ▲]

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See detailLevallois et Gravettien
Otte, Marcel ULg; Noiret, Pierre ULg

in Praehistoria (in press)

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein ... [more ▼]

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein du Gravettien touchent autant les processus de symbolisation dans l’art et les sépultures. Elles affectent différents substrats eurasiatiques, plutôt septentrionaux, comme mis en réserve dès les Néandertaliens. [less ▲]

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See detailDifferences in species–area relationships among the major lineages of land plants: a macroecological perspective
Patino Llorente, Jairo ULg; Weigelt, P.; Guilhaumon, F. et al

in Global Ecology & Biogeography (in press)

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See detailLes arabismes dans le TLF : tentative de classement historique
Baiwir, Esther ULg

in Revue de Linguistique Romane (in press), 78

Parmi les nombreux mots traditionnellement étiquetés comme «arabismes» figurent des cas relevant de classes diverses. Nous jetons ici un regard diachronique et global sur cette classe de lexèmes ... [more ▼]

Parmi les nombreux mots traditionnellement étiquetés comme «arabismes» figurent des cas relevant de classes diverses. Nous jetons ici un regard diachronique et global sur cette classe de lexèmes particuliers, parmi lesquels nous distinguons les emprunts dits directs, émanant de contacts récurrents et prolongés entre populations arabophones et populations francophones, et les emprunts dits indirects, qu'en toute rigueur nous devrions exclure de notre étude en vertu de la défiance légitime envers l'etimologia remota. Nous tentons cependant de montrer que cette méfiance mérite d'être nuancée à l'aune des conclusions que cette pratique lexicographique permet de tirer sur les mouvements socio-historiques qu'elle illustre. En effet, de l'examen des itinéraires et des époques d'emprunt se dégage l'histoire des relations entre monde arabophone et monde roman. [less ▲]

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See detailSpore assemblages from Upper Ordovician and Lowermost Silurian sediments recovered from the Qusaiba-1 shallow core hole, Qasim region, central Saudi Arabia
Wellman, Charles H.; Steemans, Philippe ULg; Miller, M.A.

in Review of Palaeobotany and Palynology (in press), ?

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See detailData processing of vibrational chemical imaging for pharmaceutical applications.
Sacre, Pierre-Yves ULg; De Bleye, Charlotte ULg; Chavez, Pierre-François ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (in press)

Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational ... [more ▼]

Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational spectroscopy to imaging techniques and allows therefore the visualization of distribution of compounds, crystallization processes. However, these techniques provide a huge amount of data that must be processed to extract the relevant information. This review presents fundamental concepts of hyperspectral imaging, the basic theory of the most used chemometric tools used to pre-process, process and post-process the generated data. The last part of the present paper focuses on pharmaceutical applications of hyperspectral imaging and highlights the data processing approaches to enable the reader making the best choice among the different tools available. [less ▲]

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See detailObservations sur l'évolution du coût du Bonus Logement pour la Wallonie
Xhignesse, Guillaume ULg

in Revue de Fiscalité Régionale et Locale (in press)

En 2011, les dépenses fiscales relatives à l'acquisition de l'habitation propre atteignaient 1.941,83 milllions d'euros dans le budget fédéral belge, soit 0,53% du PIB national. Dès l'entrée en vigueur de ... [more ▼]

En 2011, les dépenses fiscales relatives à l'acquisition de l'habitation propre atteignaient 1.941,83 milllions d'euros dans le budget fédéral belge, soit 0,53% du PIB national. Dès l'entrée en vigueur de la sixième réforme de l'Etat, ces dépenses seront à charge des budgets régionaux. Au vu des montants importants qui sont en jeu, il est nécessaire d'amorcer une réflexion sur ces aides à l'acquisition. Cette réflexion doit avant tout porter sur l'adéquation de ces aides avec les enjeux actuels et futurs en matière de logement, ainsi que sur les effets réels de ces mécanismes. Si, malgré ces interrogations, les décideurs politiques choisissent de maintenir le système en l'état, il est utile d'estimer quels seront les coûts pour les années à venir. Cette contribution se concentre sur ce dernier aspect du problème, dans le cas de la Wallonie. [less ▲]

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See detailThe role of olfaction in wireworms: a review on foraging behavior and sensory apparatus
Barsics, Fanny ULg; Haubruge, Eric ULg; Francis, Frédéric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use ... [more ▼]

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use biotic and abiotic signals to orientate towards target plant organs. Development of efficient techniques for implementation in integrated strategies relies upon improved knowledge of this process. In particular, an important step consists of elucidating the role of volatile organic compounds (VOC), emitted by belowground plant organs, in wireworm chemical ecology. This would have a positive impact on push-pull strategies and varietal selection developed against these insects. Literature In this work, we summarized the available data regarding wireworm foraging behavior as well as variables that should be considered when studying the potential role of plant-produced volatile semiochemicals. This includes CO2 gradients and other host-related cues, temperature, relative humidity and soil moisture, and wireworm physiological stage. We also review what is known of the sensory apparatus of wireworms, since this is involved in every step of the foraging process. Conclusion Some baseline data for studying VOC related wireworm foraging behavior exists. Using it as a tool in applied entomology should result in discovery of the semiochemicals that underpin trophic interactions involving these pests. However, most of the key pest species are not fully described with regards to the parameters detailed here. Obtaining accurate information to fill the current knowledge gaps will be needed in order to devise new integrated management strategies. [less ▲]

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See detailEffet du mode de conservation d’huile de Jatropha curcas L. sur son efficacité dans la lutte contre les principaux insectes ravageurs du niébé (Vigna unguiculata (L.) Walp. au Niger
Abdoul Habou, zakari; Toudou, Adam; Haubruge, Eric ULg et al

in Tropicultura (in press)

Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to ... [more ▼]

Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to light and the other kept in the dark. The insecticidal efficacy was evaluated in a field with three concentrations (5, 10 and 15%) trial on the main pests of Cowpea (Vigna unguiculata (L.) Walp) and in a laboratory test on Megalurothrips sjostedti Trybon (Thysanoptera: Thripidae) with different concentrations of crude oil (50; 100; 150 and 200 µl). No difference in insecticidal effect was found between the two modes of oil conservation, both in the laboratory and in the field. In the field, regardless of the mode of conservation, the concentrations of 10% of J. curcas oil enables a reduction of over than 80% of thrips, aphids, and bugs compared to the control. Its increased seeds yield more than 50%. The concentration of 15% gives an insecticidal effect comparable to that of the reference treatment (deltaméthrine) but induces phytotoxicity symptoms on the leaves of Cowpea. [less ▲]

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See detailMultiscale variability of amphipod assemblages in Posidonia oceanica meadows
Sturaro, Nicolas ULg; Lepoint, Gilles ULg; Vermeulen, Simon et al

in Journal of Sea Research (in press)

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and ... [more ▼]

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and conservation. Amphipod crustaceans are key organisms in seagrass ecosystems. However, little attention has been paid to the spatial scales at which amphipod assemblages may vary. We examined variability patterns of amphipod populations inhabiting Posidonia oceanica meadows, over spatial scales spanning four orders of magnitude (1 to 1000 metres) and for two consecutive years. This study reports the scales that contributed most to spatial variation of amphipod assemblages and explores the potential processes of the observed patterns, with particular emphasis on habitat features. The number of species, the diversity and the density of some species, exhibited high variation across years. Most species showed the highest spatial variation in density and biomass at small scales (~1 and 10 m). Based on density data, the structure of amphipod assemblages did not differ at any scales investigated. The patchiness that occurred at small scales may have been only weakly related to habitat features. Instead, we postulated that behavioural processes of amphipods were likely good explanatory factors. Although, the small scale spatial variability can be an important feature of amphipod assemblages in P. oceanica meadows, many patterns probably remained undetected as they may occur at scales smaller than those investigated. [less ▲]

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See detailLa première interprétation heideggérienne de la Monadologie
Pieron, Julien ULg

in Philosophie (in press)

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See detailConcentration, Activity and Biochemical Characterization of Myeloperoxidase in Fresh and Post-thaw equine semen and their Implication on Freezability
Ponthier, Jérôme ULg; Franck, Thierry ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (in press)

Myeloperoxidase (MPO) is a pro-oxidant enzyme associated with decreased motility in thawed equine semen. This study aimed to describe MPO concentration, activity and subunits in raw and thawed semen and ... [more ▼]

Myeloperoxidase (MPO) is a pro-oxidant enzyme associated with decreased motility in thawed equine semen. This study aimed to describe MPO concentration, activity and subunits in raw and thawed semen and to correlate these data with motilities in raw and thawed semen. Semen samples from five stallions were collected four times. Motilities were assessed in raw and thawed semen. MPO assays were performed in raw seminal plasma, raw sperm-rich pellet and thawed semen. Total and active MPO concentrations were, respectively, assayed by enzyme-linked immunosorbent assay and specific immunological extraction followed by enzymatic detection. MPO subunits present in semen were characterized by Western 3 blot. Purified active MPO was added in PBS and freezing extender to control its activity during freezing procedure. Differences between medians were determined using Kruskal– Wallis test, and correlations were determined using Spearman’s test for nonparametric data. Active MPO concentration was low in seminal plasma and thawed semen, but high in pellet (p = 0.0058), as the opposite relation was observed for total MPO concentration (p < 0.0001). In seminal plasma and post- thaw semen, inactive 86-kDa MPO precursor was mainly observed. Purified MPO activity was decreased in the extender (p = 0.0286). MPO activity in pellet was highly correlated with thawed progressive motility (r = 􏰑0.5576, p = 0.0086). Inac- tive MPO precursor and unknown low molecular weight inactive MPO precursor subunits explain low MPO activity in semen. Major MPO activity was observed in pellet, and post- thaw loss of activity is partially explained by MPO inactiva- tion in extender. Thawed semen motility was negatively correlated with MPO activity in pellet, becoming a potential freezability predictor. [less ▲]

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See detailRésolution de problèmes mathématiques et développement de compétences : comment soutenir les élèves dans leur apprentissage ? Editorial.
Fagnant, Annick ULg; Marcoux, Géry; Vlassis, Joëlle

in Cahiers des Sciences de l'Education (Les) (in press), 36

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See detailA generic anisotropic continuum damage model integration scheme adaptable to both ductile damage and biological damage-like situations
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (in press)

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations ... [more ▼]

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations. For this purpose a staggered time integration scheme in a finite strain framework is presented, together with an analytical consistent tangent operator. The only restrictive hypothesis is to work with an undamaged isotropic material, assumed here to follow a J2 plasticity model. The only anisotropy considered is thus a damage-induced anisotropy. The possibility to couple any damage rate law with the present algorithm is illustrated with a classical ductile damage model for aluminium, and a biological damage-like application. The later proposes an original bone remodelling law coupled to trabecular bone plasticity for the simulation of orthodontic tooth movements. All the developments have been considered in the framework of the implicit non-linear finite element code Metafor (developed at the LTAS/MN2L, University of Liège, Belgium - www.metafor.ltas.ulg.ac.be). [less ▲]

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See detailDominant amphipods of Posidonia oceanica seagrass meadows display considerable trophic diversity
Michel, Loïc ULg; Dauby, Patrick ULg; Gobert, Sylvie ULg et al

in Marine Ecology (in press)

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica ... [more ▼]

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica seagrass meadows and to highlight trophic diversity among this community. Our results indicate that, although all dominant species heavily relied on macroalgal epiphytes, considerable interspecific dietary differences existed. Carbon stable isotope ratios notably showed that some of the amphipod species favored grazing on epiphytes from leaves or litter fragments (Apherusa chiereghinii, Aora spinicornis, Gammarus aequicauda), while others like Dexamine spiniventris preferred epiphytes from rhizomes. The remaining amphipods (Caprella acanthifera, Ampithoe helleri and Gammarella fucicola) readily consumed both groups. In addition, SIAR modeling suggested that most species had a mixed diet, and relied on several food items. Fatty acid analysis and gut contents revealed that contribution of microepiphytic diatoms and of benthic and suspended particulate organic matter to the diet of amphipods were anecdotal. None of the examined species seemed to graze on their seagrass host (low 18:2(n-6) and 18:3(n-3) fatty acids contents), but G. aequicauda partly relied on seagrass leaf detritus, as demonstrated by the lesser 13C-depletion of their tissues. Overall, our findings suggest that amphipods, because of their importance in transfers of organic matter from primary producers and detritus to higher rank consumers, are key-items in P. oceanica associated food webs. [less ▲]

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See detailCan the collapse of a fly ash heap develop into an air-fluidized flow? - Reanalysis of the Jupille accident (1961)
Stilmant, Frédéric ULg; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Geomorphology (in press)

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of ... [more ▼]

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of fluidization attracted scientific attention. As drillings and direct observations revealed no water-saturated zone at the base of the deposits, scientists assumed an air-fluidization mechanism, which appeared consistent with the properties of the material. In this paper, the air-fluidization assumption is tested based on two-dimensional numerical simulations. The numerical model has been developed so as to focus on the most prominent processes governing the flow, with parameters constrained by their physical interpretation. Results are compared to accurate field observations and are presented for different stages in the model enhancement, so as to provide a base for a discussion of the relative influence of pore pressure dissipation and pore pressure generation. These results show that the apparently high diffusion coefficient that characterizes the dissipation of air pore pressures is in fact sufficiently low for an important degree of fluidization to be maintained during a flow of hundreds of meters. [less ▲]

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See detailCalibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Cristol, Jean-Paul et al

in Journal of Nephrology (in press)

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay ... [more ▼]

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to interassay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results (‘compensated Jaffe method’). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR[60 ml/ min/1.73 m2). Analytical limitations have led to the recommendation to give a grade ([60 ml/min/1.73 m2) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m2 (with MDRD) and 120 ml/min/1.73 m2 (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund– Malmo¨ (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated. [less ▲]

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See detailNatural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.
Langers, Inge ULg; Renoux, Virginie; Reschner, Anca et al

in European journal of immunology (in press)

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since ... [more ▼]

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since NK cells collaborate with dendritic cells (DCs) to induce an immune response against viral infections and tumors, we studied the impact of this crosstalk in the context of HPV vaccination. NK cells in the presence of HPV-VLPs enhanced DC maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10. This activation was bi-directional. Indeed, in the presence of HPV-VLPs, DCs further activated NK cells by inducing the upregulation of cell surface activation markers (CD69 and HLA-DR). The function of NK cells was also improved as shown by an increase in IFN-gamma secretion and cytotoxic activity against an HPV+ cell line. This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated. Our results provide insight into how VLPs interact with innate immune cells and how NK cells and DCs play a role in the immune response induced by this vaccine agent. This article is protected by copyright. All rights reserved. [less ▲]

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See detailFungal biofilm reactor improves the productivity of hydrophobin HFBII
Khalesi, Mohammadreza; Zune, Quentin ULg; Telek, Samuel ULg et al

in Biochemical Engineering Journal (in press)

Production and purification of hydrophobin HFBII has recently been the subject of intensive research, but the yield of production needs to be further improved for a generic use of this molecule at ... [more ▼]

Production and purification of hydrophobin HFBII has recently been the subject of intensive research, but the yield of production needs to be further improved for a generic use of this molecule at industrial scale. In a first step, the influence of different carbon sources on the growth of Trichoderma reesei and the production of HFBII was investigated. The optimum productivity was obtained by using 40 g/L lactose. Carbon starvation and excretion of extracellular enzyme were determined as two main conditions for the production of HFBII. In the second phase, and according to the physiological mechanisms observed during the screening phase, a bioreactor set up has been designed and two modes of cultures have been investigated, i.e. the classical submerged fermentation and a fungal biofilm reactor. In this last set-up, the broth is continuously recirculated on a metal packing exhibiting a high specific surface. In this case, the fungal biomass was mainly attached to the metal packing, leading to a simplification of downstream processing scheme. More importantly, the HFBII concentration increased up to 48.6 ± 6.2 mg/L which was 1.8 times higher in this reactor configuration and faster than the submerged culture. X-ray tomography analysis shows that the biofilm overgrowth occurs when successive cultures are performed on the same packing. However, this phenomenon has no significant influence on the yield of HFBII, suggesting that this process could be operated in continuous mode. Protein hydrolysis during stationary phase was observed by MALDI-TOF analysis according to the removal of the last amino acid from the structure of HFBII after 48 h from the beginning of fermentation in biofilm reactor. Hopefully this modification does not lead to alternation of the main physicochemical properties of HFBII. [less ▲]

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See detailSoutenir le développement des compétences des enseignants du supérieur par la documentation, l’investigation et le partage des pratiques en classe
Poumay, Marianne ULg; Georges, François ULg

in Dossiers des Sciences de l'Education (Les) (in press)

L’article aborde le développement professionnel des enseignants à travers un master complémentaire en pédagogie de l’enseignement supérieur. Orientée recherche, cette formation met en œuvre les principes ... [more ▼]

L’article aborde le développement professionnel des enseignants à travers un master complémentaire en pédagogie de l’enseignement supérieur. Orientée recherche, cette formation met en œuvre les principes du courant « SoTL ». Elle préconise une documentation de ses pratiques, une investigation de type scientifique de l’apprentissage des étudiants dans sa propre classe et une production de connaissance par le partage de ses avancées. Les articles de régulation rédigés à l’issue de la formation par une cohorte de dix participants montrent leur réelle inscription dans ce courant « SoTL » ; une enquête donne par ailleurs des indices d’efficacité de la formation sur ces mêmes critères à moyen terme. [less ▲]

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See detailSinging ability is rooted in vocal-motor control of pitch
Hutchins, Sean; Larrouy, Pauline ULg; Peretz, Isabelle

in Attention, Perception & Psychophysics (in press)

The inability to vocally match a pitch can be caused by poor pitch perception or by poor vocal-motor control. Although previous studies have tried to examine the relationship between pitch perception and ... [more ▼]

The inability to vocally match a pitch can be caused by poor pitch perception or by poor vocal-motor control. Although previous studies have tried to examine the relationship between pitch perception and vocal production, they have failed to control for the timbre of the target to be matched. In the present study, we compare pitch matching accuracy with an unfamiliar instrument (the slider) and with the voice, designed such that the slider plays back recordings of the participant’s own voice. We also measured pitch accuracy in singing a familiar melody (“Happy Birthday”) to assess the relationship between single pitch matching tasks and melodic singing. Our results showed that participants (all nonmusicians) were significantly better at matching recordings of their own voices with the slider than with their voice, indicating that vocal-motor control is an important limiting factor on singing ability. We also found significant correlations between the ability to sing a melody in tune and vocal pitch matching, but not instrumental pitch matching. Better melodic singers also tended to have higher quality voices (as measured by acoustic variables). These results provide important evidence about the ultimate causes of poor singing ability, and demonstrate that single pitch matching tasks can be useful in measuring general singing abilities. [less ▲]

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See detailApproche par compétences et évaluation à large échelle : deux logiques incompatibles ?
Dierendonck, Christophe; Fagnant, Annick ULg

in Mesure et Evaluation en Education [=MEE] (in press), 37(1), 43-82

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See detailLe Mur et le masque. À propos de Banksy.
Saint-Amand, Denis ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailSurfactant-assisted ultrasonic spray pyrolysis of nickel oxide and lithium-doped nickel oxide thin films, towards electrochromic applications
Denayer, Jessica ULg; Bister, Geoffroy; Simonis, Priscilla et al

in Applied Surface Science (in press)

Lithium-doped nickel oxide and undoped nickel oxide thin films have been deposited on FTO/glass substrates by a surfactant-assisted ultrasonic spray pyrolysis. The addition of polyethylene glycol in the ... [more ▼]

Lithium-doped nickel oxide and undoped nickel oxide thin films have been deposited on FTO/glass substrates by a surfactant-assisted ultrasonic spray pyrolysis. The addition of polyethylene glycol in the sprayed solution has led to improved uniformity and reduced light scattering compared to films made without surfactant. Furthermore, the presence of lithium ions in NiO films has resulted in improved electrochromic performances (coloration contrast and efficiency), but with a slight decrease of the electrochromic switching kinetics. [less ▲]

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See detailDépister la fragilité, un bénéfice pour le patient et pour le soignant
RICOUR, Céline ULg; DESAINTHUBERT, Marie; GILLAIN, Sophie ULg et al

in Revue Médicale de Liège (in press)

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See detailBrain metabolic dysfunction in Capgras delusion during Alzheimer’s disease: a positron emission tomography study
Jedidi, Haroun ULg; Daury, Noémy; Rémi, Capa et al

in American Journal of Alzheimer's Disease & Other Dementias (in press)

Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since ... [more ▼]

Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer’s disease (AD) and Capgras syndrome was compared with those of 24 healthy elderly subjects and 26 AD patients without delusional syndrome. Compared to the healthy and AD groups, the patient had significant hypometabolism in frontal and posterior midline structures. In light of current neural models of face perception, our patient’s Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex. [less ▲]

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See detailEvaluation of the impact of 6-month training by whole body vibration on the risk of falls among nursing home residents, observed over a 12-month period: a single blind, randomized controlled trial.
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Maquet, Didier ULg et al

in Aging Clinical & Experimental Research (in press)

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement ... [more ▼]

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement of motor capacity were observed. OBJECTIVE: The objective of the present study was to evaluate the impact of 6-month training by WBV on functional and motor abilities among nursing home residents observed over a 12-month period. METHODS: Patients were randomized into two groups: the WBV group which received three training sessions every week composed of five series of 15 s of vibration at 30 Hz intensity for a period of 6 months and a control group with normal daily life. The impact of this training on the risk of falls was assessed blindly after 6 and 12 months by the Tinetti Test, the "Timed Up and Go" test and a quantitative evaluation of a 10-s walk performed with a tri-axial accelerometer. The occurrence of falls was also observed. RESULTS: 62 elderly healthy volunteers, (47 women and 15 men, mean age 83.2 +/- 7.9 years) were included in this study. There was no significant difference between the two groups regarding the Tinetti test (p = 0.75), the "Timed Up and Go" test (p = 0.19) and the Locometrix(R) test, except for the step length, measured by dual task (p < 0.01). No significant inter-group difference in the frequency of falls was observed during the 12 months of research. A total of 42 falls were recorded during the first 6 months of experimentation: 24 falls in the treated group and 18 in the control group (p = 0.60). During the next 6 months, 19 falls occurred: 8 falls in the treated group and 11 in the control group (p = 0.52). CONCLUSION: This study failed to establish the effectiveness of low doses of WBV, under the conditions used in our study, on functional and motor abilities of institutionalized elderly patients. However, given the positive results of other studies, further investigations, with modified therapeutic protocols, seem necessary to clarify the effects of WBV in the elderly. [less ▲]

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See detailLe point sur l’évaluation de la force des muscles respiratoires
Kellens, Isabelle ULg; Crielaard, Jean-Michel ULg

in Revue Médicale de Liège (in press)

The strength of respiratory muscles is crucial for quality of life, especially for patients with lung or neurological disorders. Several methods can be used to assess them: i.e direct or indirect ... [more ▼]

The strength of respiratory muscles is crucial for quality of life, especially for patients with lung or neurological disorders. Several methods can be used to assess them: i.e direct or indirect, voluntary or involuntary. The conventional spirometry method assesses indirectly the respiratory function by measuring maximum inspiratory and expiratory pressure, which reflects the coordination of all respiratory muscles. Techniques of magnetic and electrical stimulation can detect a specific muscle dysfunction, independently of the patient's motivation, however they are invasive methods as measurements are made in the esophagus and stomach. The voluntary techniques are generally non-invasive and require patient's cooperation. Measures of respiratory muscle strength, coupled to a conventional spirometry, can predict the development of ventilatory support in patients at risk, and may be useful during weaning from mechanical ventilation in intensive care units. [less ▲]

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See detailAn ecological study of Electra posidoniae Gautier, 1954 (Cheilostomata, Anasca), a bryozoan epiphyte solely found on the seagrass Posidonia oceanica (L.) Delile, 1813
Lepoint, Gilles ULg; Mouchette, Olivier; Pelaprat, Corine et al

in Belgian Journal of Zoology (in press)

The bryozoan Electra posidoniae Gautier is found solely on the leaves of the Neptune grass Posidonia oceanica (L.) Delile, dominating the leaf epifauna of this seagrass. Epiphytes of marine angiosperms ... [more ▼]

The bryozoan Electra posidoniae Gautier is found solely on the leaves of the Neptune grass Posidonia oceanica (L.) Delile, dominating the leaf epifauna of this seagrass. Epiphytes of marine angiosperms (or seagrasses) often play an important role in ecosystem functioning, for example as food web suppliers. As dysfunction of epiphytic compartment is often implied in human-induced seagrass decline, it is important to understand the dynamics and life traits of this community in pristine areas. This study involved the monthly assessment of colonization dynamics, biomass seasonality and diet composition through stable isotopes measurements of E. posidoniae at a depth of 10 m in the Revellata Bay (Corsica, Mediterranean Sea). Ancestrulae (i.e. colony founders) appeared towards the end of winter and were very selective in their settlement position along the P. oceanica leaves. A maximum of 100,000 colonies per square meter was recorded. E. posidoniae colonies dominated the epiphytic community biomass in early spring, and were over-covered by epiphytic algae in June. Food shortage could be also involved in this decrease. Although stable isotope ratios of C, N and S showed that this suspension feeder mainly relies on the water column productivity for its food, other food sources such as re-suspended epiphytic diatoms could be important in late spring (i.e. after the phytoplanktonic bloom). Additionally, a contribution of seagrass phytodetritus to the diet of this species cannot be excluded. The species was almost absent in winter, raising the question of its recruitment in spring. This study confirms the quantitative importance of this species in the seagrass meadow and explores its role in the relationship between the water column and this seagrass ecosystem. [less ▲]

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See detailStochastic modelling of reservoir sedimentation in a semi-arid watershed
Adam, Nicolas; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Water Resources Management (in press)

Sedimentation in large reservoirs is a major concern in semi-arid regions characterized by severe seasonal water scarcity. As a contribution to improved sediment management, this study analyses the real ... [more ▼]

Sedimentation in large reservoirs is a major concern in semi-arid regions characterized by severe seasonal water scarcity. As a contribution to improved sediment management, this study analyses the real case of the reservoir of Sidi Yacoub in the north of Algeria. First, a dynamic model of the reservoir was set up and used to estimate past water and sediment inflows (period 1990-2010) based on data recorded by the dam operator and measurements at a gauging station located downstream of the reservoir. Second, in a stochastic framework using the statistical characteristics of inflow and outflow discharges, a projection of future sedimentation was performed until 2030, assuming stationarity of the statistical distributions. Third, the model was used to investigate the influence of possible climate change and to quantify the positive effects of soil conservation measures upstream. [less ▲]

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See detailOn the asymptotic standard error of a class of robust estimators of ability in dichotomous item response models
Magis, David ULg

in British Journal of Mathematical & Statistical Psychology (in press)

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods ... [more ▼]

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods were introduced to lessen the impact of such aberrant responses onto the estimation process. The computation of asymptotic (i.e., large sample) standard errors (ASE) for these robust estimators, however, has not been fully considered yet. This paper focuses on a broad class of robust ability estimators, defined by an appropriate selection of the weight function and the residual measure, for which the ASE is derived from the theory of estimating equations. The maximum likelihood (ML) and the robust estimators, together with their estimated ASE, are then compared through a simulation study. It is concluded that both the estimators and their ASE perform similarly in absence of response disturbances, while the robust estimator and its estimated ASE are less biased and outperform their ML counterparts in presence of response disturbances with large impact on the item response process. [less ▲]

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See detailSens et signification dans l'esthétique de Mallarmé
Durand, Pascal ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press), 5

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See detailA New Shift-Share Method
Artige, Lionel ULg; Van Neuss, Leif ULg

in Growth and Change (in press)

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant ... [more ▼]

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant variable) relative to the national average. This technique has always been subject to criticism for its lack of theoretical basis. This paper presents a critical assessment of the methods suggested by Dunn (1960) and by Esteban-Marquillas (1972) and proposes a new shift-share method, which separates out the two effects unambiguously. By way of illustration, we provide an application to manufacturing employment in the Belgian provinces between 1995 and 2007. [less ▲]

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See detailGender effect on the scapular 3D posture and kinematic in healthy subjects
Schwartz, Cédric ULg; Croisier, Jean-Louis ULg; Rigaux, Elise et al

in Clinical Physiology and Functional Imaging (in press)

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However ... [more ▼]

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However the literature reports, for the shoulder, differences in the range of motion between genders. The specific influence of gender on the scapula-thoracic kinematics has not been studied yet. The dominant shoulder of two populations of men and women composed of 11 subjects each were evaluated in three dimensions for three distinct motions: flexion in the sagittal plane, abduction in the frontal plane and gleno-humeral internal/external rotation with the arm abducted at 90°. Posture, kinematics and range of motion were studied separately. For flexion and abduction and with regard to the scapular kinematic, external rotation were significantly larger for women than men. The differences were of at least 5° at 120° of humeral elevation. Upward rotations were identical. Women also showed larger average active humero-thoracic range of motion. The mean differences were of 13°, 7°, 12° and 5° for abduction, flexion, internal rotation and external rotation, respectively. No difference was observed between the scapular resting positions of both populations. The observed differences concerning both the scapular and humeral patterns would indicate that the shoulder behavior of men and women should not be expected to be similar. [less ▲]

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See detailPérils de la copie : les cas de l’Estoire del Saint Graal, du Merlin et de la Suite Vulgate
Combes, Annie ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailClinical pattern characterisation of cattle naturally infected by BTV-8 - Clinical characterisation of BTV-8 infected cattle
Zanella, G; Martinelle, Ludovic ULg; Guyot, Hugues ULg et al

in Transboundary and Emerging Diseases (in press)

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See detailMesoporous amorphous tungsten oxide electrochromic films: a Raman analysis of their good switching behavior
Chatzikyriakou, Dafni ULg; Krins, Natacha ULg; Gilbert, Bernard ULg et al

in Electrochimica Acta (in press)

The intercalation and de-intercalation of lithium cations in electrochromic tungsten oxide thin films are significantly influenced by their structural and surface characteristics. In this study, we ... [more ▼]

The intercalation and de-intercalation of lithium cations in electrochromic tungsten oxide thin films are significantly influenced by their structural and surface characteristics. In this study, we prepared two types of amorphous films via the sol-gel technique: one dense and one mesoporous in order to compare their response upon lithium intercalation and de-intercalation. According to chronoamperometric measurements, Li+ intercalates/de-intercalates faster in the mesoporous film (24s/6s) than in the dense film (48s/10s). The electrochemical measurements (cyclic voltammetry and chronoamperometry) also showed worse reversibility for the dense film compared to the mesoporous film, giving rise to important Li+ trapping and remaining coloration of the film. Raman analysis showed that the mesoporous film provides more accessible and various W-O surface bonds for Li+ intercalation. On the contrary, in the first electrochemical insertion and de-insertion in the dense film, Li+ selectively reacts with a few surface W-O bonds and preferentially intercalates into pre-existing crystallites to form stable irreversible LixWO3 bronze. [less ▲]

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See detailThe effects of vitamin D on skeletal muscle strength, muscle mass and muscle power: a systematic review and meta-analysis of randomized controlled trials.
Beaudart, Charlotte ULg; Buckinx, Fanny ULg; Rabenda, Véronique ULg et al

in The Journal of clinical endocrinology and metabolism (in press)

Context There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle. Objective To summarize with a meta-analyse the effects of vitamin D supplementation on muscle ... [more ▼]

Context There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle. Objective To summarize with a meta-analyse the effects of vitamin D supplementation on muscle function. Data sources A systematic research of randomized controlled trials, performed between 1966 and January 2014 has been conducted on Medline, Cochrane Database of Systematics Reviews, Cochrane Central Register of Controlled and completed by a manual review of the literature and congressional abstracts. Study selection All forms and doses of vitamin D supplementation, with or without calcium supplementation, compared with placebo or control were included. Out of the 225 potentially relevant articles, 30 randomized controlled trials involving 5615 individuals (mean age: 61.1 years) met the inclusion criteria. Data extraction Data were extracted by two independent reviewers. Data synthesis Results revealed a small but significant positive effect of vitamin D supplementation on global muscle strength with a standardized mean difference (SMD) of 0.17 (p=0.02). No significant effect was found on muscle mass (SMD 0.058; p=0.52) or muscle power (SMD 0.057; p=0.657). Results on muscle strength were significantly more important with people who presented a 25-hydroxyvitamin D level <30 nmol/L. Supplementation seems also more effective on people aged 65 years or older compared to younger subjects (SMD 0.25; 95% CI 0.01 to 0.48 versus SMD 0.03; 95% CI -0.08 to 0.14). Conclusions Vitamin D supplementation has a small positive impact on muscle strength but additional studies are needed to define optimal treatment modalities, including dose, mode of administration and duration. [less ▲]

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See detailNégocier une majorité politique et devenir bourgmestre en Belgique. Quelles influences des droits régionaux ?
Grandjean, Geoffrey ULg

in Revue Régionale de Droit [= RRD] (in press)

Depuis 2001, les Régions sont compétentes en matière d’organisation et d’élection des pouvoirs locaux. Elles ont adopté des règles différentes. Dans quelle mesure ces règles influencent-elles la ... [more ▼]

Depuis 2001, les Régions sont compétentes en matière d’organisation et d’élection des pouvoirs locaux. Elles ont adopté des règles différentes. Dans quelle mesure ces règles influencent-elles la négociation d’une majorité politique et la désignation des bourgmestres en Belgique ? Afin de répondre à cette question, des entretiens semi-directifs ont été réalisés avec plusieurs bourgmestres et échevin issus de communes localisées dans les trois Régions. Des différences entre Régions mais également au sein de celles-ci ont été relevées. Les dispositions relatives au mode de désignation du bourgmestre sont primordiales pour comprendre les dynamiques de négociations politiques. Au final, cet article tisse les liens entre les normes juridiques et les jeux des acteurs politiques. [less ▲]

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See detailA European survey on attitudes towards pain and end-of-life issues in locked-in syndrome
Demertzi, Athina ULg; Jox, Ralf J; Racine, Eric et al

in Brain Injury (in press)

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in ... [more ▼]

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in syndrome. Methods: Close-ended survey among conference attendees from 33 European countries. Analysis included chi-square tests and logistic regressions. Results: From the 3332 respondents (33% physicians, 18% other clinicians, 49% other professions; 47% religious), 90% agreed that patients with locked-in syndrome can feel pain. The majority (75%) disagreed with treatment withdrawal, but 56% did not wish to be kept alive if they imagined themselves in this condition (p50.001). Religious and southern Europeans opposed to treatment withdrawal more often than non-religious (p50.001) and participants from the North (p¼0.001). When the locked-in syndrome was compared to disorders of consciousness, more respondents endorsed that being in a chronic locked-in syndrome was worse than being in a vegetative state or minimally conscious state for patients (59%) than they thought for families (40%, p50.001). Conclusions: Personal characteristics mediate opinions about locked-in syndrome. The dissociation between personal preferences and general opinions underlie the difference in perspective in disability. Ethical responses to dilemmas involving patients with locked-in syndrome should consider the diverging ethical attitudes of stakeholders. [less ▲]

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See detailÀ propos de deux pièges en psychopathologie
Englebert, Jérôme ULg

in Le Cercle Herméneutique (in press), 22

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See detailComplementary biophysical tools to investigate lipid specificity in the interaction between bioactive molecules and the plasma membrane: A review
Deleu, Magali ULg; Crowet, Jean-Marc ULg; Nasir, Mehmet Nail ULg et al

in Biochimica et Biophysica Acta - Biomembranes (in press)

Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic ... [more ▼]

Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic structures. The interactions between bioactive molecules and lipids are important for numerous processes, from drug bioavailablility to viral fusion. The cell membrane is a carefully balanced environment and any change inflicted upon its structure by a bioactive molecule must be considered in conjunction with the overall effect that this may have on the function and integrity of the membrane. Conceptually, understanding the molecular mechanisms by which bioactive molecules interact with cell membranes is of fundamental importance. Lipid specificity is a key factor for the detailed understanding of the penetration and/or activity of lipid-interacting molecules and of mechanisms of some diseases. Further investigation in that way should improve drug discovery and development of membrane-active molecules in many domains such as health, plant protection or microbiology. In this review, we will present complementary biophysical approaches that can give information about lipid specificity at a molecular point of view. Examples of application will be given for different molecule types, from biomolecules to pharmacological drugs. A special emphasis is given to cyclic lipopeptides since they are interesting molecules in the scope of this review by combining a peptidic moiety and a lipidic tail and by exerting their activity via specific interactions with the plasma membrane. [less ▲]

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See detailA note on weighted likelihood and Jeffreys modal estimation of proficiency levels in polytomous item response models
Magis, David ULg

in Psychometrika (in press)

Warm (1989) established the equivalence between the so-called Jeffreys modal and the weighted likelihood estimators of proficiency level with some dichotomous item response models. The purpose of this ... [more ▼]

Warm (1989) established the equivalence between the so-called Jeffreys modal and the weighted likelihood estimators of proficiency level with some dichotomous item response models. The purpose of this note is to extend this result to polytomous item response models. First, a general condition is derived to ensure the perfect equivalence between these two estimators. Second, it is shown that this condition is fulfilled by two broad classes of polytomous models including, among others, the partial credit, rating scale, graded response and nominal response models. [less ▲]

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See detailGlycine receptors control the generation of projection neurons in the developing cerebral cortex
Avila, Ariel; Vidal, P.M.; Tielens, Sylvia ULg et al

in Cell Death & Differentiation (in press)

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See detailPhénoménologie brentanienne
Dewalque, Arnaud ULg

in Austriaca (in press)

Mon ambition est de mettre en lumière quelques traits distinctifs du programme d’analyse de l’esprit développé par Franz Brentano et les membres de son école. Plus spécialement, je suggérerai qu’il y a un ... [more ▼]

Mon ambition est de mettre en lumière quelques traits distinctifs du programme d’analyse de l’esprit développé par Franz Brentano et les membres de son école. Plus spécialement, je suggérerai qu’il y a un sens à parler d’une authentique phénoménologie brentanienne. J’entends par là un programme de recherche original, distinct notamment de la phénoménologie de Husserl – qui, à partir de 1903, n’est plus conçue comme une psychologie empirique ni, a fortiori, comme une psychologie expérimentale – et de la « phénoménologie » de Stumpf – qui, se rattachant à la tradition plus ancienne d’une Empfindungslehre, désigne exclusivement l’étude des phénomènes sensibles ou des matériaux sensoriels . Ma conviction est qu’un examen attentif des caractéristiques propres à la phénoménologie ou psychologie descriptive d’inspiration brentanienne est une bonne manière de donner un sens à l’expression de « phénoménologie autrichienne » qui a été proposée, dans la littérature, pour désigner le champ d’investigation ouvert par Brentano et les brentaniens. [less ▲]

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See detailEstimated daily intake and cumulative risk assessment of phthalate diesters in a Belgian general population
Dewalque, Lucas ULg; Charlier, Corinne ULg; PIRARD, Catherine ULg

in Toxicology Letters (in press)

The daily intakes (DI) were estimated in a Belgian general population for 5 phthalates, namely diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), butylbenzyl phthalate ... [more ▼]

The daily intakes (DI) were estimated in a Belgian general population for 5 phthalates, namely diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), butylbenzyl phthalate (BBzP) and di-2-ethylhexyl phthalate (DEHP), based on the urinary measurements of their corresponding metabolites. DI values ranged between <LOD and 59.65 μg/kg bw/day depending on the congener, and were globally higher for children than adults. They were compared to acceptable levels of exposure (tolerable daily intakes) to evaluate the hazard quotients (HQ), which highlight an intake above the dose considered as safe for values greater than 1. If very few of our Belgian participants exceeded this threshold for phthalates considered individually, 6.2% of the adults and 25% of the children showed an excessive hazard index (HI) which took into account the cumulative risk of adverse anti-androgenic effects. These results are of concern since these HI were based on only 3 phthalates (DEHP, DiBP and DnBP), and showed a median of 0.55 and 0.29 for children and adults respectively. The comparison with previously determined dietary intakes demonstrated that for DEHP, food intake was nearly the only route of exposure while other pathways occurred mainly for the other studied phthalates. [less ▲]

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See detailSome misunderstood or unknown LaTeX tricks (XIV) and LaTeX learning curve
Merciadri, Luca ULg

in TUGboat (in press)

We will here give three tricks: i. using a personalized \overline, ii. boxing every digit of an integer, iii. using \scalebox. I will then expose my point of view about the LaTeX learning curve, and give ... [more ▼]

We will here give three tricks: i. using a personalized \overline, ii. boxing every digit of an integer, iii. using \scalebox. I will then expose my point of view about the LaTeX learning curve, and give some of the most common beginners’ mistakes. [less ▲]

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See detailBesoins psychosociaux et perception d'iniquité: combinaison de méthodes d'action pour venir en aide aux conjoints de patients atteints d'un cancer - Une étude pilote
Wagener, Aurélie ULg; Bragard, Isabelle ULg; Jonius, Bénédicte et al

in Journal de Thérapie Comportementale et Cognitive (in press)

Cancer is a chronic illness that impacts both patients and family members. Spouses will often take on a caregiver role, meeting psychosocial needs such as health professional needs and information needs ... [more ▼]

Cancer is a chronic illness that impacts both patients and family members. Spouses will often take on a caregiver role, meeting psychosocial needs such as health professional needs and information needs. This caregiver role can also create emotional distress. Moreover, spouses might experience perceived inequity characterized by a combination of feelings of overinvestment and of underbenefit. This perception of inequity can also lead to emotional distress. Given the consequences of cancer on spouses, psychological interventions may be one means for helping them to cope. In this study, cognitive and behavioural methods are proposed to spouses in order to support them facing their partner’s cancer and their own issues. The overriding objective of this study is to satisfy the psychosocial needs of cancer patient spouses. In order to reach this objective, it compares the efficacy of two methods of action: 1/ hierarchical organization of psychosocial needs and problem-solving, and 2/ hierarchical organization of psychosocial needs alone. This research also aims to assess the influence of the perception of inequity that spouses might feel on the utilization of the two methods of action. The main hypothesis was that the combination of the two methods of action would have a greater and intensified impact on the assessed dependant variables than the utilization of the hierarchical organization of psychosocial needs alone. Thirty-seven spouses were randomly assigned into two groups: the experimental group (n= 19) and the control group (n= 18). The methodology provided identical protocols to the two groups with one difference in that the training period differed in order to measure the effect of training for problem-solving skills. The average age of participants in the experimental group was 58 (SD = 11) on average, and 57 (SD = 11) in the control group. They were asked to complete several questionnaires at three different time periods with a three-week time interval (T0, T1 and T2) assessing these dependent variables: psychosocial needs and emotional distress (anxiety and depression). Socio-demographic data and the perception of inequity were only evaluated at T0. At T0, all participants realized a hierarchy of psychosocial needs. Between T0 and T1, the experimental group trained in the problem-solving method while control group trained between T1 and T2 for this method. Repeated ANOVA measures were conducted to assess the evolution of the psychosocial needs. Student t-tests were computed to assess the influence of inequity perception on the utilization of the two methods of action. The results confirmed previous findings demonstrating the psychosocial needs in spouses of cancer patients. Indeed, it appears that these participants perceive more psychosocial needs than those of similar samples. This difference might be explained by the period of our intervention which occurred earlier than in experimental designs of similar studies. The overall emotional distress felt by our participants was characterized by anxiety. Therefore, being the caregiver of a cancer patient seems to foster anxiety more than depression. The results confirmed the main hypothesis showing a significant decrease of the number of unsatisfied psychosocial needs when participants have used the two methods of action. This decrease was observed whenever the combination was implemented. In other words, the combination of the two methods of action optimized meeting psychosocial needs. However, the perception of inequity did not seem to influence the utilization of these two methods. This research presents some limitations in the form of a small sample size and of a single assessment of inequity perception at T0. Nevertheless, the results of this preliminary study remain interesting and promising: further research could enhance the employed experimental design in a larger sample in order to obtain more robust results. [less ▲]

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See detailProteins in the gas phase
Meyer, Tim; Gabelica, Valérie ULg; Grubmüller, Helmut et al

in Wiley Interdisciplinary Reviews: Computational Molecular Science (in press)

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins ... [more ▼]

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins have thus been carried out in aqueous environment. However, recent experimental approaches have opened the possibility to gain structural information on proteins from gas-phase measurements. The obtained results revealed significant structural memory in proteins when transferred from water to the gas phase. However, after several years of experimental and theoretical research, the nature of the structural changes induced by vaporization, the exact characteristics of proteins in the gas phase, and the physicochemical forces stabilizing dehydrated proteins are still unclear. We will review here these issues using both experimental and theoretical sources of information. [less ▲]

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See detailInfluence of noise correction on intra- and inter-subject variability of quantitative metrics in diffusion kurtosis imaging
André, Elodie ULg; Grinberg, Farida; Farrher, Ezequiel et al

in PLoS ONE (in press)

Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing new biomarkers. Given the rapidly increasing ... [more ▼]

Diffusion kurtosis imaging (DKI) is a promising extension of diffusion tensor imaging, giving new insights into the white matter microstructure and providing new biomarkers. Given the rapidly increasing number of studies, DKI has a potential to establish itself as a valuable tool in brain diagnostics. However, to become a routine procedure, DKI still needs to be improved in terms of robustness, reliability, and reproducibility. As it requires acquisitions at higher diffusion31 weightings, results are more affected by noise than in diffusion tensor imaging. The lack of standard procedures for post-processing, especially for noise correction, might become a significant obstacle for the use of DKI in clinical routine limiting its application. We considered two noise correction schemes accounting for the noise properties of multichannel phased-array coils, in order to improve the data quality at signal-to-noise ratio (SNR) typical for DKI. The SNR dependence of estimated DKI metrics such as mean kurtosis (MK), mean diffusivity (MD) and fractional anisotropy (FA) is investigated for these noise correction approaches in Monte Carlo simulations and in in vivo human studies. The intra-subject reproducibility is investigated in a single subject study by varying the SNR level and SNR spatial distribution. Then the impact of the noise correction on inter-subject variability is evaluated in a homogeneous sample of 25 healthy volunteers. Results show a strong impact of noise correction on the MK estimate, while the estimation of FA and MD was affected to a lesser extent. Both intra- and inter-subject SNR related variability of the MK estimate is considerably reduced after correction for the noise bias, providing more accurate and reproducible measures. In this work, we have proposed a straightforward method that improves accuracy of DKI metrics. This should contribute to standardization of DKI applications in clinical studies and making valuable inferences in group analysis and longitudinal studies. [less ▲]

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See detailIsland floras are not necessarily more species-poor than continental ones.
Patiño, J.; Solymos, P.; Carine, M.A. et al

in Journal of Biogeography (in press)

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See detailIsotopic tracing of sediment components that are assimilated by epibiontic juveniles of Holothuria scabra (Holothuroidea)
Plotieau, Thomas; Lepoint, Gilles ULg; Lavitra, Thiery et al

in Journal of the Marine Biological Association of the United Kingdom (in press)

Despite H. scabra’s wide distribution and status as one of the best candidates for sustaining the development of tropical sea cucumber aquaculture, very few data are available regarding the organic ... [more ▼]

Despite H. scabra’s wide distribution and status as one of the best candidates for sustaining the development of tropical sea cucumber aquaculture, very few data are available regarding the organic fraction it assimilates in practice. In this study we report experimental results where H. scabra’s diet was supplemented with various 15N-labelled organic fractions of sediment. We used juveniles weighing between 38- 88 mg at the beginning of the experiment (ca. 2 cm long and 30 days old). Their growth was measured over a four week period and their 15N composition recorded. The results showed that H. scabra juveniles assimilated all added organic components from both dissolved and particulate fractions of the sediment. Bacteria seem to be an important food source for juveniles, even more so than microphytobenthos (diatoms). [less ▲]

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See detailStakeholder incentives and aid effectiveness: A case study in the health district of Kayes in Mali
Devahive, Eva; Paul, Elisabeth ULg; Samaké, Salif et al

in Journal of Development Studies (in press)

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar ... [more ▼]

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar degree. Most projects have limited impact on health services, but many programmes supported by donors offer positive opportunities for health system strengthening. The representations of different categories of stakeholders diverge – notably, regarding the role of different actors in service provision. A number of consistent strategic logics influence actors’ behaviour. We show that while many donors have committed at global level to respect aid effectiveness principles, implementation lags behind. [less ▲]

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See detailEnjeux de la vannerie dans 1 les aires protégées de Madagascar
Guillaud, Sylvie; Vermeulen, Cédric ULg

in Bois et Forêts des Tropiques (in press)

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See detailP2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice
Darbousset, Roxane; Delierneux, Céline ULg; Mezouar, Soraya et al

in Blood (in press)

Adenosine Triphosphate (ATP) and its metabolite, adenosine, are key regulators of polymorphonuclear neutrophils (PMNs) functions. PMNs have recently been implicated in the initiation of thrombosis. We ... [more ▼]

Adenosine Triphosphate (ATP) and its metabolite, adenosine, are key regulators of polymorphonuclear neutrophils (PMNs) functions. PMNs have recently been implicated in the initiation of thrombosis. We investigated the role of ATP and adenosine in PMN activation and recruitment at the site of endothelial injury. Following binding to the injured vessel wall, PMNs are activated and release elastase. The recruitment of PMNs and the subsequent fibrin generation and thrombus formation are strongly affected in mice deficient in the P2X1-ATP receptor and in wild-type mice treated with CGS 21680, an agonist of the A2A adenosine receptor or NF449 a P2X1 antagonist. Infusion of wild-type PMNs into P2X1-deficient mice increases fibrin generation but not thrombus formation. Restoration of thrombosis requires infusion of both platelets and PMNs from wild-type mice. In vitro, ATP activates PMNs, whereas CGS 21680 prevents their binding to activated endothelial cells. These data indicate that ATP contributes to PMN activation leading to their adhesion at the site of laser-induced endothelial injury, a necessary step leading to the generation of fibrin and subsequent platelet-dependent thrombus formation. Altogether, our study identifies previously unknown mechanisms by which ATP and adenosine are key molecules involved in thrombosis by regulating the activation state of PMNs. [less ▲]

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See detailEfficacy and safety of currently marketed anti-osteoporosis medications
Reginster, Jean-Yves ULg; NEUPREZ, Audrey ULg; Dardenne, Nadia ULg et al

in Best Practice & Research. Clinical Endocrinology & Metabolism (in press)

During the past 2 decades, many interventions were proven effective in the management of postmenopausal osteoporosis. The objective of an anti-osteoporosis treatment is to reduce fracture rates, ideally ... [more ▼]

During the past 2 decades, many interventions were proven effective in the management of postmenopausal osteoporosis. The objective of an anti-osteoporosis treatment is to reduce fracture rates, ideally at all skeletal sites (i.e. spine, hip, and other non-spine). The armamentarium against osteoporosis includes anti-resorptive agents (i.e. bisphosphonates, selective estrogen receptor modulators and denosumab), bone-forming agents (i.e. peptides from the parathyroid hormone family) and one agent with a dual mechanism of action (i.e. strontium ranelate). All these medications combine anti-fracture efficacy with a reasonable benefit/risk profile. However, the choice of a particular chemical entity, in one individual patient is based on the knowledge and expertise of the physician. Prioritization of drugs should be based on the individual profile of the patient, the severity of osteoporosis and the specific contraindications, warnings and precautions of use of the various available medications. [less ▲]

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See detailInteraction between dietary protein content and the source of carbohydrates along the gastrointestinal tract of weaned piglets.
Pieper, Robert; Boudry, Christelle ULg; Bindelle, Jérôme ULg et al

in Archives of Animal Nutrition (in press)

Although fermentable carbohydrates (CHO) can reduce metabolites derived from dietary protein fermentation in the intestine of pigs, the interaction between site of fermentation and substrate availability ... [more ▼]

Although fermentable carbohydrates (CHO) can reduce metabolites derived from dietary protein fermentation in the intestine of pigs, the interaction between site of fermentation and substrate availability along the gut is still unclear. The current study aimed at determining the impact of two different sources of carbohydrates in diets with low or very high protein content on microbial metabolite profiles along the gastrointestinal tract of piglets. Thirty-six piglets (n = 6 per group) were fed diets high (26%, HP) or low (18%, LP) in dietary protein and with or without two different sources of carbohydrates (12% sugar beet pulp, SBP, or 8% lignocellulose, LNC) in a 2 × 3 factorial design. After 3 weeks, contents from stomach, jejunum, ileum, caecum, proximal and distal colon were taken and analysed for major bacterial metabolites (D-lactate, L-lactate, short chain fatty acids, ammonia, amines, phenols and indols). Results indicate considerable fermentation of CHO and protein already in the stomach. HP diets increased the formation of ammonia, amines, phenolic and indolic compounds throughout the different parts of the intestine with most pronounced effects in the distal colon. Dietary SBP inclusion in LP diets favoured the formation of cadaverine in the proximal parts of the intestine. SBP mainly increased CHO-derived metabolites such as SCFA and lactate and decreased protein-derived metabolites in the large intestine. Based on metabolite profiles, LNC was partly fermented in the distal large intestine and reduced mainly phenols, indols and cadaverine, but not ammonia. Multivariate analysis confirmed more diet-specific metabolite patterns in the stomach, whereas the CHO addition was the main determinant in the caecum and proximal colon. The protein level mainly influenced the metabolite patterns in the distal colon. The results confirm the importance of CHO source to influence the formation of metabolites derived from protein fermentation along the intestinal tract of the pig. [less ▲]

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See detailBreed-specific hematologic reference intervals in healthy adult Dogue de Bordeaux dogs
Lavoué, Rachel; Geffré, A; Braun, JP et al

in Veterinary Clinical Pathology (in press)

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See detailPractical management of Chronic Myeloid Leukemia in Belgium
Benghiat, FS.; Beguin, Yves ULg; Dessars, B. et al

in Belgian Journal of Hematology (in press)

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation ... [more ▼]

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation tyrosine kinase inhibitors (TKIs) and the possibility of treatment discontinuation made the management of these patients more challenging. In this review, practical management guidelines of CML are presented, adapted to the Belgian situation in 2014. In first line chronic phase patients, imatinib, nilotinib and dasatinib can be prescribed. While second generation TKIs give faster and deeper responses, their impact on long-term survival remain to be determined. The choice of the TKI depends on CML risk score, priority for a deep response to allow a treatment-free remission protocol, age, presence of comorbid conditions, side effect profile, drug interactions, compliance concerns and price. Monitoring the response has to be made according the 2013 ELN criteria, and is based on the bone-marrow cytogenetic response during the first months and on the blood molecular response. Molecular follow-up is sufficient in patients with a complete cytogenetic response. For patients who fail frontline therapy, nilotinib, dasatinib, bosutinib and ponatinib are an option depending of the type of intolerance or resistance. T315I patients are only sensitive to ponatinib, which has to be carefully handled due to cardiovascular toxicity. Advanced phase diseases are more difficult to handle, with treatments including allogeneic stem cell transplantation, which is also an option for patients failing at least two TKIs. The possibility of treatment-free remission and pregnancy are also discussed. [less ▲]

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See detailAn algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Bruyère, Olivier ULg; Cooper, C; Pelletier, JP et al

in Seminars in Arthritis & Rheumatism (in press)

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to ... [more ▼]

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to develop a treatment algorithm recommendation that is easier to interpret for the prescribing physician based on the available evidence and that is applicable in Europe and internationally. The knee was used as the model OA joint. Methods: ESCEO assembled a task force of 13 international experts (rheumatologists, clinical epidemiologists, and clinical scientists). Existing guidelines were reviewed; all interventions listed and recent evidence were retrieved using established databases. A first schematic flow chart with treatment prioritization was discussed in a 1-day meeting and shaped to the treatment algorithm. Fine-tuning occurred by electronic communication and three consultation rounds until consensus. Results: Basic principles consist of the need for a combined pharmacological and non-pharmacological treatment with a core set of initial measures, including information access/education, weight loss if overweight, and an appropriate exercise program. Four multimodal steps are then established. Step 1 consists of background therapy, either non-pharmacological (referral to a physical therapist for re-alignment treatment if needed and sequential introduction of further physical interventions initially and at any time thereafter) or pharmacological. The latter consists of chronic Symptomatic Slow-Acting Drugs for OA (e.g., prescription glucosamine sulfate and/or chondroitin sulfate) with paracetamol at-need; topical NSAIDs are added in the still symptomatic patient. Step 2 consists of the advanced pharmacological management in the persistent symptomatic patient and is centered on the use of oral COX-2 selective or non-selective NSAIDs, chosen based on concomitant risk factors, with intra-articular corticosteroids or hyaluronate for further symptom relief if insufficient. In Step 3, the last pharmacological attempts before surgery are represented by weak opioids and other central analgesics. Finally, Step 4 consists of end-stage disease management and surgery, with classical opioids as a difficult-to-manage alternative when surgery is contraindicated. Conclusions: The proposed treatment algorithm may represent a new framework for the development of future guidelines for the management of OA, more easily accessible to physicians. © 2014 The Authors. [less ▲]

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See detailMicrowave-assisted thermochemical and primary hydrolytic conversions of lignocellulosic resources: a review
Richel, Aurore ULg; Jacquet, Nicolas ULg

in Biomass Conversion and Biorefinery (in press)

Faced with the inevitable depletion of fossil resources, agricultural productions have rapidly emerged as promising renewable alternatives. Particularly, the conversion of lignocellulosic materials has ... [more ▼]

Faced with the inevitable depletion of fossil resources, agricultural productions have rapidly emerged as promising renewable alternatives. Particularly, the conversion of lignocellulosic materials has nowadays opened new vistas for the production of energy, biofuels and chemicals. In this literature review, microwave technology is described as an original heating source either for the thermochemical conversions (at temperatures up to 400°C) of lignocellulose into biofuels or the pretreatment (below 400°C) and further hydrolysis of lignocellulose into bioethanol and other valuable chemicals. Advantages of microwave approaches include a commonly observed acceleration in reaction rate and improved selectivities and yields. [less ▲]

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