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See detailLe trouble bipolaire de l’adolescent : Comment favoriser un diagnostic et une prise en charge précoce ?
Simon, Michaël ULg

in Acta Psychiatrica Belgica (in press)

In half the cases, bipolar disorder begins before adulthood. The usual long delay between its onset and the establishment of proper treatment has adverse effects on the developing brain. The prognosis of ... [more ▼]

In half the cases, bipolar disorder begins before adulthood. The usual long delay between its onset and the establishment of proper treatment has adverse effects on the developing brain. The prognosis of the disease could be improved by early diagnosis and treatment. From the case of a manic episode in a 16 year old teenager, we discuss the characteristics of manic prodromes, their diagnostic criteria and therapeutic means. We then criticize the concept of diagnosis in the stage of prodromal symptoms. We propose to dispense with the need for diagnosis and promote access to mental health care to any person with mental suffering. [less ▲]

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See detailMicrobiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015)
Filippitzi, ME; Goumperis, T; Robinson, T et al

in Transboundary and emerging diseases (in press)

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULg; Pieron, Julien ULg

in Dissensus (in press)

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See detailNeeds-Supplies Fit and Behavioral Outcomes: The Mediating Role of Organizational Identification
Travaglianti, Fabrice ULg; Babic, Audrey ULg; Pepermans, Roland et al

in Journal of Management & Organization (in press)

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See detailEvaluation of different hydrocolloids to improve dough rheological properties and bread quality of potato-wheat flour
Liu, Xingli ULg; Mu, Taihua; Yamul, Karim Diego et al

in Journal of Industrial and Engineering Chemistry (in press)

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato ... [more ▼]

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato-wheat dough (the mass ratio was 1:1) rheological, fermentation properties and its bread quality. The tan δ of potato-wheat dough was significantly increased by adding HPMC compared to those of without adding hydrocolloids (from 0.337 to 0.425), which was close to wheat dough (0.531). Moreover, the dough height during fermentation process was significantly improved by adding hydrocolloids, with the order of HPMC (23.1mm) > AP (19.3mm) > AG (18.6mm) > KG (13.6mm). In addition, the potato-wheat protein bands of potato-wheat dough turned pale by adding hydrocolloids, suggesting higher molecular weight aggregation formed between proteins-hydrocolloids or proteins-proteins after fermentation process. Furthermore, HPMC significantly increased specific volume (from 1.45 to 2.22 ml/g), and hydrocolloids restrained the starch retrogradation of potato-wheat breads. [less ▲]

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See detailJésus caricaturé ? À propos des Proses évangéliques
Saint-Amand, Denis ULg; Roland, Florine

in Parade Sauvage (in press), 27

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See detailThe impact of architectural representations on conveying design intent.
Cunin, Maxime; Yang, Maria C.; Elsen, Catherine ULg

in AI EDAM: Artificial Intelligence for Engineering Design Analysis and Manufacturing (in press)

Architects express themselves graphically in order to communicate ideas both to clients and to themselves. In practice, they rely on a variety of representations such as free-hand drawings, 3D computer ... [more ▼]

Architects express themselves graphically in order to communicate ideas both to clients and to themselves. In practice, they rely on a variety of representations such as free-hand drawings, 3D computer rendered images, and photomontages to convey their design intent. Research to date has demonstrated differences and commonalities in the ways in which expert designers and laymen perceive visual understanding. It is still unclear how architects themselves use different types of representations to express different intentions, and how accurately their expected audience perceives those intentions. The purpose of this research is to investigate how laymen interpret the initial design intent of an architect’s design, and what role different forms of representations play in this process of understanding a design. This paper describes a five-step process for developing a survey that was used to gather data from 686 laymen respondents. It was found that certain types of simpler representations presented in specific contexts are unexpectedly found to be a more efficient way to faithfully transmit an architectural intent. [less ▲]

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See detailMorphological integration and alternative life history strategies: a case study in a facultatively paedomorphic newt
Tomašević, Natasa; Cvijanović, Milena; Denoël, Mathieu ULg et al

in Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution (in press)

Tetrapod limbs are serially homologous structures that represent a particularly interesting model for studies on morphological integration, i.e. the tendency of developmental systems to produce correlated ... [more ▼]

Tetrapod limbs are serially homologous structures that represent a particularly interesting model for studies on morphological integration, i.e. the tendency of developmental systems to produce correlated variation. In newts, limbs develop at an early larval stage and grow continuously, including after the habitat transition from water to land following metamorphosis. However, aquatic and terrestrial environments impose different constraints and locomotor modes that could affect patterns of morphological integration and evolvability. We hypothesize that this would be the case for alternative heterochronic morphs in newts, i.e. aquatic paedomorphs that keep gills at the adult stage and adult metamorphs that are able to disperse on land. To this end, we analysed patterns and strengths of correlations between homologous skeletal elements of the fore- and hindlimbs as well as among skeletal elements within limbs in both phenotypes in the alpine newt, Ichthyosaura alpestris. Our results showed that metamorphs and paedomorphs had similar, general patterns of limb integration. Partial correlations between homologous limb elements and within limb elements were higher in paedomorphs when compared to metamorphs. Decrease in partial correlation between homologous limb elements in metamorphs is accompanied with a higher evolvability of the terrestrial morph. All these results indicate that environmental demands shaped the patterns of morphological integration of alpine newt limbs and that the observed diversity in correlation structure could be related to a qualitative difference in the modes of locomotion between the morphs. [less ▲]

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See detailDe l’usage de la photographie dans une enquête ethno-sociologique sur la mémoire de l’exil et de l’immigration espagnols en Belgique
Molina Marmol, Maïté ULg

in RELAIS Revue du laboratoire d'études et de recherches sur l'interculturel (in press)

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See detailIdentification of bacterial strains isolated from the traditional date product "Btana" produced in south regions of Algeria
Abekhti, Abdelkader; Taminiau, Bernard ULg; Kihal, Mabrouk et al

in Folia Microbiologica (in press)

Eleven samples of the traditional date product " Btana" prepared by direct (DBM) and indirect method (UBM) were analysed to characterize their bacterial diversity. A total of 42 representative isolates ... [more ▼]

Eleven samples of the traditional date product " Btana" prepared by direct (DBM) and indirect method (UBM) were analysed to characterize their bacterial diversity. A total of 42 representative isolates have been chosen for molecular identification. 16S rRNA gene sequencing revealed the presence of 20 species within 30.9% belonged to the genus Bacillus, 28.6% of the Staphylococcus, and Enterococcus genus. Within the minority represented species, two isolates were identified as Paenibacillus (isolated from UBM exclusively), Streptococci salivarius, Lactobacillus sakei and Klebsiella pneumoniae. Preliminary results indicate that IBM is more selective for spore former bacilli contrary to DBM that show more diversity in the bacterial flora with a prevalence of Enterococcus. API ZYM test showed that the bacilli species have a weak hydrolase activity. [less ▲]

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See detailAberrations chromatiques : de l’émulsion au pixel
Thonon, Jonathan ULg

in Cahiers Louis Lumière (in press)

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la ... [more ▼]

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la profondeur picturale et de son articulation à la surface : « La nature n'est pas en surface ; elle est en profondeur. Les couleurs sont l'expression, à cette surface, de cette profondeur. Elles montent des racines du monde ». Cet « organisme de couleurs » que constitue le monde est transcrit dans la peinture de Cézanne par une dynamique symbiotique de la couleur et du dessin, de la ligne et du pan. La couleur restitue, par sa masse, son surgissement, son homogénéité, presque sa viscosité, la véritable chaire perceptive du monde ; une vision qui tient à distance la perspective géométrique, photographique, cinématographique fondée sur la transparence et qui repose, comme le signale Merleau-Ponty, sur la « réversibilité des dimensions » (surface-profondeur) et l’entrelacement des choses. C’est cette épaisseur du visible rendu par la couleur que l’économie de l’image numérique nous permet de redécouvrir, moins dans le registre de la « tactilité » de l’image et la picturalité du pixel, que par l’intégration, entre le support et l’image (parfois indiscernables dans le régime optique), d’un « corps » algorithmique qui règle l’actualisation du visible. Certains défauts techniques du dispositif numérique, aujourd’hui élevés au rang de pratique artistique, permettent de révéler cette matrice qui utilise alors la couleur et la coulure comme mode de visibilité. C’est le cas du Datamoshing, technique de composition numérique qui revisite tout en la radicalisant la pratique de l’incrustation vidéo. Basée sur la perturbation volontaire d’éléments de la matrice, cette technique transforme les couleurs en une forme malléable et fluide révélant ainsi leur double nature spatiale : elles sont à la fois dans l’espace de l’image et l’espace de l’image lui-même. Ces expériences de défigurations d’images s’inscrivent dans le registre des « aberrations chromatiques » dont nous proposons ici une rapide généalogie avant d’interroger la couleur digitale dans ses spécificités. [less ▲]

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See detailDemeter's Arrival at Eleusis on an Apulian Oinochoe kept in Foggia
Cuvelier, Graham ULg

in Babesch : Bulletin Antieke Beschaving (in press)

This article offers an interpretation of the scene depicted on the body of an Apulian red-figured oinochoe, assigned to the Darius Painter, now kept in the storage of the Museo Civico of Foggia. This ... [more ▼]

This article offers an interpretation of the scene depicted on the body of an Apulian red-figured oinochoe, assigned to the Darius Painter, now kept in the storage of the Museo Civico of Foggia. This interpretation is based on the analysis of the iconographic language of the Apulian imagery as well as on the connexion in series of this scene with those appearing on contemporary vases produced in the same cultural community. This article is also accompanied by a set of previously unpublished colour pictures (of the entire vase and of several details) taken on site by the author. [less ▲]

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See detailPer una edizione integrale e analitica dell'incipit della Storia d'Italia di Francesco Guicciardini
Moreno, Paola ULg

in Laboratoire Italien : Politique et Société (in press)

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See detailRNA-seq-based genome reannotation of dermatophyte Arthroderma benhamiae, characterization of its secretome and whole gene expression profile during infection
Tran, T; De Coi, N; Feuermann, M et al

in Genome Announcements (in press)

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See detailCommon Clays of Foumban area (West Cameroon): Variability, Distribution, Characterization and Potential Applications
Nkalih Mefire, Abiba ULg

in Journal of African Earth Sciences (in press)

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and ... [more ▼]

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and suitability in ceramic product. The analytical results were obtained by X-ray diffraction, X-ray fluorescence spectrometry, Thermogravimetric Analysis, Scanning Electron Microscopy, and Fourier Transform Infrared Spectrometry. Morphologically, an homogeneous clayey layer was found in the upper part of a laterite cover on interfluves, and a clayey heterogeneous hydromorphic material in valleys. They are minerallogically composed of kaolinite (25-84%), illite (0-18%), smectite (0- 31%), and chlorite (0-8 %), associated with quartz (2-44 %), K-feldspars (0-27 %.), plagioclase (0-26%), goethite; (0-9%) with traces of rutile and hematite (≤5 %). The geochemical analysis shows a 115 relative large amount of SiO2 (45-71%), Al2O3 (14-31%), and low Fe2O3 (up to 11 %) suggesting weathering of mainly granitic and rhyolitic parent rocks. Most studied clays could be applied to building ceramic product such as bricks (refractory or not) and tiles. Illite may promote the glassy phase responsible for the densification of the final product. In addition, the relatively high proportion of alkali elements (K2O + Na2O, 6-8%) in some samples from Marom, Koutaba and is responsible for low firing temperature. However the presence of smectite (up to 5 %) limits the application of some Koutaba and Marom clays for ceramic building. The high Fe2O3 contents (> 8 %) in some Bangourain clays implied some pretreatment. [less ▲]

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See detailPatterns of metal distribution in hypersaline microbialites during early diagenesis: Implications for the fossil record
Sforna, Marie-Catherine ULg; Daye, Mirna; Philippot, Pascal et al

in Geobiology (in press)

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See detailNew insights on the Picasso’s Blue Period painting La famille Soler through non-invasive imaging and analytical techniques
Defeyt, Catherine ULg; Walter, Philippe; Rousselière, Hélène et al

in Studies in Conservation (in press)

The material study of La Famille Soler through non-invasive imaging, molecular, structural and elemental techniques, permitted a relevant re-examination of this singular blue period painting, which is ... [more ▼]

The material study of La Famille Soler through non-invasive imaging, molecular, structural and elemental techniques, permitted a relevant re-examination of this singular blue period painting, which is considered as the earliest Picasso’s version of Le déjeuner sur l’herbe by E. Manet. On the one hand, it was concluded that the underlying landscape painted by Vidal in 1903 referred to Manet’s masterpiece. On the other hand, it was assumed that the cubist sketch undertaken by Picasso in 1912, prior to the current blue background, consists of an uncompleted transformation of Vidal’s landscape into synthetic cubism. Additionally, the main pigments associated to the underlying compositions were successfully identified. [less ▲]

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See detailSupplementation with 80,000 IU vitamin D3/month between November and April corrects vitamin D insufficiency without overdosing: Effect on serum 25-hydroxyvitamin D serum concentrations.
Tournier, Herve; Tran, Nicole; Dray, Nathalie et al

in Presse medicale (Paris, France : 1983) (in press)

INTRODUCTION: Vitamin D insufficiency, defined by a 25-hydroxyvitamin D (25OHD) serum concentration<20ng/mL, is highly frequent in the French general population, especially between November and April. The ... [more ▼]

INTRODUCTION: Vitamin D insufficiency, defined by a 25-hydroxyvitamin D (25OHD) serum concentration<20ng/mL, is highly frequent in the French general population, especially between November and April. The aim of this study was to evaluate whether 80,000 IU vitamin D3 every month during this period of the year was able to maintain a 25OHD level between 20 and 60ng/mL in apparently healthy subjects whatever their basal vitamin D status. METHODS: Ninety-eight subjects volunteered to receive an 80,000 IU vitamin D3 dose every month between November 2014 and April 2015. Serum 25OHD, calcemia and calciuria were measured just before the first dose (Month 0), just before the 4th dose (M4), and one month after the 6th dose (M7). RESULTS: At M0, 25OHD was 17.5+/-9.5ng/mL. Sixty subjects (61.2%) had a 25OHD<20ng/mL and 25 (25.5%) had a 25OHD<10ng/mL. 25OHD increased significantly at M4 (35.3+/-8.0ng/mL) and M7 (40.1+/-8.5) without change in calcemia and calciuria. At M4, 2 subjects had a 25OHD slightly below 20ng/mL (17.6 and 19.7ng/mL), and none had a concentration>60ng/mL. At M7, all had a serum 25OHD>20ng/mL and 2 subjects had a value slightly above 60ng/mL (62.1 and 63.2ng/mL). CONCLUSION: A monthly supplementation with 80,000 IU vitamin D3 between November and April corrected vitamin D insufficiency in subjects in whom it was initially very frequent, without overdosing. This protocol is simple, safe and costless, and can be easily implemented when physicians detect risk factors for hypovitaminosis D in patients for whom a 25OHD measurement is not indicated. [less ▲]

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See detailEffect of different parameters on composition of volatile components of Myristica fragrans seeds extracted by hydrodistillation assisted by microwave and head-space solid-phase microextraction
Bouchachia, C; Benkaci-Ali, F; Eppe, Gauthier ULg et al

in Journal of Essential Oil Research (in press)

Hydrodistillation assisted by microwave (HDAM) and Head space solid phase micro-extraction (HSSPME) of Myristica fragrans houtt (MF) were investigated. A kinetic study was performed for MF seeds using two ... [more ▼]

Hydrodistillation assisted by microwave (HDAM) and Head space solid phase micro-extraction (HSSPME) of Myristica fragrans houtt (MF) were investigated. A kinetic study was performed for MF seeds using two techniques (HDAM: Hydrodistillation assisted by microwave and SDAM: steam distillation assisted by microwave). The effect of the cryogenic grinding (CG) showed differences in yields and composition of volatile oils compared to the simple grinding (SG). HDAM–SG (3.4%) and SDAM–SG (2.55%) allowed extraction of substantial amounts of volatile oils in less time compared with HDAM–CG (4.75%) and SDAM–CG (3.8%). The kinetic study (differential and accumulated yields) of essential oil extraction was quantitatively and qualitatively performed showing a significant variation of composition with the extraction time, especially for accumulated yields such as sabinene (31.48–38.78%), α-pinene (12.74–14.09%) and β-pinene (10.01–12.11%). Similarly, the HS-SPME–GC–MS analysis showed also a significant variation of MF seeds volatile composition according some parameters as the type of fibre coating (PDMS: Polydimethylsiloxane and PDMS– DVB: Polydimethylsiloxane divenylbenzene), particle size, grinding mode and the mass used. The chemical groups (monoterpenoids, aliphatic and aromatic alcohols and esters) showed specific behaviour in SPME analysis. SPME sampling parameters were optimized for these components. [less ▲]

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See detailEarliest Mississippian rugose corals of eastern Australia: post-disaster fauna across the Devonian-Carboniferous Boundary?
Denayer, Julien ULg; Webb, Gregory

in Palaeodiversity & Palaeoenvironments (in press)

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See detailLe phénotype d’Akhenaton ; revue critique entre canons artistiques et expression pathologique.
JEDIDI, Zayd ULg; JEDIDI, Haroun ULg; LAVEAUX, Elisabeth ULg et al

in Revue Médicale de Liège (in press)

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 ... [more ▼]

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 years after their time. Tenth pharaoh of this dynasty and father of Tutankhamun, Akhenaten (Amenhotep/Amenhotep IV) still fascinates Egyptologists and history lovers through the many questions surrounding his atypical rule. One of the most striking aspects of the so-called Amarna period concerns the representations of the pharaoh himself, very confusing compared to the traditional iconography of the New Kingdom. These intriguing portraits of Pharaoh raised a whole lot of medical assumptions, more or less substantiated. We review here the main theories developed throughout history. [less ▲]

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See detailIdentification of proteins from wild cardoon flowers (Cynara cardunculus L.) by a proteomic approach
Ben Amira, Amal; Bauwens, Julien ULg; De Pauw, Edwin ULg et al

in Journal of Chemical Biology (in press)

Proteomic approach was applied to identify total proteins, particularly the enzymatic content, from wild cardoon flowers. As the selection of an appropriate sample preparation method is the key for ... [more ▼]

Proteomic approach was applied to identify total proteins, particularly the enzymatic content, from wild cardoon flowers. As the selection of an appropriate sample preparation method is the key for getting reliable results, two different extraction/precipitation methods (trichloroacetic acid and phenol/ammonium acetate) were tested on fresh and lyophilized flowers. After two-dimensional electrophoresis (2D–E) separations, a better protein pattern was obtained after phenol extraction from lyophilized flowers. Only 46 % of the total analyzed spots resulted in a protein identification by mass spectrometry MALDI-TOF. Four proteases (cardosins A, E, G, and H), which have become a subject of great interest in dairy technology, were identified. They presented molecular weights and isoelectric points very close and high levels of homology between matched peptides sequences. The absence of the other cardosins (B, C, D, and F) could be an advantage, as it reduces the excessive proteolytic activity that causes bitter flavors and texture defects, during cheese making. [less ▲]

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See detailLa traduction dans le domaine hagiographique médiolatin : l’apport de la linguistique quantitative
Philippart de Foy, Caroline ULg

in Rursus (in press), 9

Au fil des siècles, le corpus latin des vitae sanctorum et des passiones martyrum s’est enrichi par l’introduction de nouveaux textes, par la réécriture et l’adaptation d’anciens remis au goût du jour ... [more ▼]

Au fil des siècles, le corpus latin des vitae sanctorum et des passiones martyrum s’est enrichi par l’introduction de nouveaux textes, par la réécriture et l’adaptation d’anciens remis au goût du jour, ainsi que par la traduction d’oeuvres issues du monde byzantin. Le phénomène de la réécriture hagiographique est bien connu et a fait l’objet de nombreux travaux. Celui de la traduction dans ce domaine reste en revanche peu exploité, tant il existe d’obstacles à son étude (absence de répertoire, manque d’éditions critiques, difficultés à identifier les traductions et les modèles grecs, etc.). Le présent travail propose une approche originale du phénomène, basée sur l’utilisation de la statistique linguistique. Cette approche consiste à étudier le latin utilisé par les traducteurs hagiographes pour rendre leur modèle grec et les techniques qu’ils ont adoptées pour le traduire en considérant les traductions non pas une à une, mais d’une manière comparative au moyen de l’analyse quantitative, dans le but de caractériser et de classer les traductions sur base de critères linguistiques, d’identifier et de qualifier des pratiques, des traditions localisées, des spécificités d’école ou de traducteur. La pratique de la traduction est examinée à travers un corpus de 35 textes représentatif des différentes phases de l’histoire de la traduction hagiographique latine au Moyen Âge et des différents foyers de traduction en Italie. Les analyses sont menées sur divers paramètres lexicaux et syntaxiques, en comparant d’abord le corpus, pris dans son ensemble, à un corpus de textes non traduits, puis en comparant entre eux les différents sous-corpus de traductions. Le premier type de comparaison (externe) a pour objectif de mettre en évidence les caractéristiques des traductions en général, le second (interne) de dégager les spécificités de chaque groupe de traductions. [less ▲]

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See detailUrethral intussusception following traumatic catheterization in a male cat
Broux, Olivier ULg; Vangrinsven, Emilie ULg; Etienne, Anne-Laure ULg et al

in Canadian Veterinary Journal = Revue Vétérinaire Canadienne (in press)

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See detailIron and Trace Element in Paediatric Parenteral Nutrition
Domellof, M; Szitanyi, P; Simchowitz, V et al

in Clinical Nutrition (in press)

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See detailIntravenous lipid emulsions in paediatric patients
Lapillonne, A; Didler Mis, N; Goulet et al

in Clinical Nutrition (in press)

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See detailDo sex reversal procedures differentially affect agonistic behaviours and sex steroid levels depending on the sexual genotype in Nile tilapia?
Gennotte, Vincent ULg; Akonkwa, Balagizi; Mélard, Charles ULg et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (in press)

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY ... [more ▼]

In Nile tilapia Oreochromis niloticus, phenotypic males and females with different sexual genotypes (XX, XY, YY) have particular behavioural and physiological traits. Compared to natural XX females and XY males, XY and YY females, and XX males expressed higher level of aggressiveness that could be related to higher levels of 17β-oestradiol and 11-ketotestosterone respectively. Our results suggest that the presence of a Y chromosome increases aggressiveness in females. However, since the same relationship between aggressiveness and the Y chromosome is not observed in males, we can hypothesize that the differences in aggressiveness are not directly dependent on the genotype but on the sex reversal procedures applied on young fry during their sexual differentiation to produce these breeders. These hormonal treatments could have permanently modified the development of the brain and consequently influenced the behaviour of adults independently of their genotype. In both hypotheses (genotype or sex reversal influence), the causes of behavioural modifications have to be searched in an early modification of the brain sexual differentiation. [less ▲]

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See detailPharmacokinetic characterization of [18F]UCB-H PET radiopharmaceutical in the rat brain.
Becker, Guillaume ULg; Warnier, Corentin; Serrano Navacerrada, Maria Elisa ULg et al

in Molecular Pharmaceutics (in press)

The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with ... [more ▼]

The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with positron emission tomography (PET), allows the assessment of synaptic density in the living brain. The first-in-class fluorinated SV2A specific radioligand, [18F]UCB-H, is now available at high-activity through an efficient radiosynthesis compliant with the current good manufacturing practices (cGMP). We report here a non-invasive method to quantify [18F]UCB-H binding in rat brain with microPET. Validation study in rats confirmed the need of high enantiomeric purity to target SV2A in vivo. We demonstrated the reliability of a population-based input function to quantify SV2A in preclinical microPET setting. Finally, we investigated the in vivo metabolism of [18F]UCB-H and confirmed the negligible amount of radiometabolites in the rat brain. Hence, the in vivo quantification of SV2A using [18F]UCB-H microPET seems a promising tool for the assessment of the synaptic density in the rat brain, and opens the way for longitudinal follow-up in neurodegenerative diseases rodents’ models. [less ▲]

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See detailAssessment of Continuous Pain in Newborns admitted to NICUs in 18 European Countries
Anand, Kanwaljeet; Eriksson, Mats; Boyle, Elaine et al

in Acta Paediatrica (in press)

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A ... [more ▼]

Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A prospective cohort study in 243 Neonatal Intensive Care Units (NICUs) from 18 European countries recorded frequency of pain assessments, use of mechanical ventilation, sedation, analgesia, or neuromuscular blockade for each neonate upto 28 days after NICU admission. Results: Only 2113/6648 (31·8%) of neonates received assessments of continuous pain, occurring variably among tracheal ventilation (TrV, 46·0%), noninvasive ventilation (NiV, 35· 0%), and no ventilation (NoV, 20· 1%) groups (p<0· 001). Daily assessments for continuous pain occurred in only 10·4% of all neonates (TrV: 14· 0%, NiV: 10· 7%, NoV: 7· 6%; p<0· 001). More frequent assessments of continuous pain occurred in NICUs with pain guidelines, nursing champions, and surgical admissions prompted (all p<0·01), and for newborns <32 weeks gestational age, those requiring ventilation, or opioids, sedatives-hypnotics, general anesthetics (O-SH-GA) (all p<0·001), or surgery (p=0· 028). Use of O-SH-GA drugs increased the odds for pain assessment in the TrV (OR:1· 60, p<0·001) and NiV groups (OR:1·40, p<0· 001). Conclusion: Assessments of continuous pain occurred in less than one-third of NICU admissions, and daily in only 10% of neonates. NICU clinical practices should consider including routine assessments of continuous pain in newborns. [less ▲]

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See detailIgnorance et maîtrise de la bête. Lefort critique de l'éducation "humaniste".
Mancuso, Eva ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailConstant 2-labellings and an application to (r,a,b)-covering codes
Vandomme, Elise ULg; Gravier, Sylvain

in Discussiones Mathematicae Graph Theory (in press)

We introduce the concept of constant 2-labelling of a vertex-weighted graph and show how it can be used to obtain perfect weighted coverings. Roughly speaking, a constant 2-labelling of a vertex-weighted ... [more ▼]

We introduce the concept of constant 2-labelling of a vertex-weighted graph and show how it can be used to obtain perfect weighted coverings. Roughly speaking, a constant 2-labelling of a vertex-weighted graph is a black and white colouring of its vertex set which preserves the sum of the weights of black vertices under some automorphisms. We study constant 2-labellings on four types of vertex-weighted cycles. Our results on cycles allow us to determine (r, a, b)-codes in Z^2 whenever |a−b|>4, r>1 and we give the precise values of a and b. This is a refinement of Axenovich’s theorem proved in 2003. [less ▲]

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See detailOrganometallic-mediated alternating radical copolymerization of tert-butyl-2- trifluoromethacrylate with vinyl acetate and synthesis of block copolymers thereof
Banerjee, Sanjib; Ladmiral, Vincent; Debuigne, Antoine ULg et al

in Macromolecular Rapid Communications (in press)

Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE ... [more ▼]

Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE) copolymers composed of two electronically distinct monomers: vinyl acetate (VAc, donor, D) and tert-butyl-2-trifluoromethacrylate (MAF-TBE, acceptor, A), with low dispersity (≤1.24) and molar masses up to 57 000 g mol−1. These copolymers have a precise 1:1 alternating structure over a wide range of comonomer feed compositions. The reactivity ratios are determined as rVAc = 0.01 ± 0.01 and rMAF-TBE = 0 at 40 °C. Remarkably, from a feed containing >50% molar VAc content, poly(VAc-alt-MAF-TBE)-b- PVAc block copolymers are produced via a one- pot synthesis. Such diblock copolymers exhibit two glass transition temperatures attributed to the alternating and homopolymer sequences. The OMRP of this fluorine-containing alter- nating monomer system may provide access to a wide range of new polymer materials. [less ▲]

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See detailCytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency
Humblet-Baron, Stephanie; Schönefeldt, Susan; Garcia-Perez, Josselyn E et al

in Journal of Allergy and Clinical Immunology (The) (in press)

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA ... [more ▼]

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA recombination causes a developmental block in T cells and B cells, resulting in high susceptibility to infections. Hypomorphic mutations in the same genes can also give a partial loss of T cells, in a spectrum including leaky SCID (LS) and Omenn syndrome (OS). These patients not only develop life-threatening infections due to immunodeficiency, but also develop inflammatory/autoimmune conditions due to the presence of autoreactive T cells. Objective: We sought to develop a preclinical model that fully recapitulates the symptoms of LS/OS patients including a model for testing therapeutic intervention. Methods: We generated a novel mutant mouse (Dclre1c leaky) that develops a LS phenotype. Mice were monitored for diseases and immune phenotype and immune function were evaluated using flow cytometry, ELISA and histology. Results: Dclre1c leaky mice present with a complete blockade of B cell differentiation, with a leaky block in T cell differentiation resulting in an oligoclonal TCR repertoire and enhanced cytokine secretion. Dclre1c leaky mice also developed inflammatory symptoms including wasting, dermatitis, colitis, hypereosinophilia and high IgE levels. Development of a preclinical murine model for LS allowed the testing of potential treatment, with administration of CTLA4-Ig reducing disease symptoms and immunological disturbance, resulting in increased survival. Conclusion: These data suggest that CTLA4-Ig should be evaluated as a potential treatment of inflammatory symptoms in LS and OS patients. [less ▲]

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See detailPotential demal exposure of florists to fungicide residues on flowers and risk assessment
Toumi; Joly, L.; Vleminckx, C. et al

in Communications in Agricultural and Applied Biological Sciences (in press)

Flowers are susceptible to many pests and diseases. Therefore, they can be sprayed several times during their growth considering that no MRL are set for flow-ers. High levels of pesticide residues ... [more ▼]

Flowers are susceptible to many pests and diseases. Therefore, they can be sprayed several times during their growth considering that no MRL are set for flow-ers. High levels of pesticide residues potentially expose daily the florists who han-dle cut flowers and possibly could endanger their health. A study was carried out to evaluate the risk for florists exposed to fungicide residues during normal profes-sional tasks. Cotton gloves were distributed to 20 florists (two pairs to each florist) and worn during two consecutive half days during normal professional tasks (from min 2 hours to max 3 hours/day) to measure their potential dermal exposure (PDE). Samples were analyzed with a multi-residue (QuEChERS) method validated by a laboratory accredited for pesticide residues and with a combination of gas and liquid chromatography tandem mass spectrometry. It appears from the results that a total of 54 fungicides with different toxicity classes were detected on cotton gloves. An average of 15.53 mg/kg fungicide residues per glove sample was meas-ured. Six of 54 are suspected of causing cancer after prolonged or repeated expo-sure. Boscalid was both the active substance for which the highest maximum and average concentrations (26.21 and 3.47 mg/kg, respectively). Famoxadone had the most critical PDE (156% AOEL for the maximum concentration). As a consequence, this study leads to conclude that Belgian florists, who worked for several years and handled a large number of flowers contaminated by high concentrations of pesti-cide residues, are exposed daily with a potential effect on their health. This sug-gests that safety standards should be set for residue levels on cut flowers. [less ▲]

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See detailThe use of time series forecasting in zone order picking systems to predict order pickers’ workload
van Gils, Teun; Ramaekers, Katrien; Caris et al

in International Journal of Production Research (in press)

In order to differentiate from competitors in terms of customer service, warehouses accept late orders while providing delivery in a quick and timely way. This trend leads to a reduced time to pick an ... [more ▼]

In order to differentiate from competitors in terms of customer service, warehouses accept late orders while providing delivery in a quick and timely way. This trend leads to a reduced time to pick an order. This paper introduces workload forecasting in a warehouse context, in particular a zone picking warehouse. Improved workforce planning can contribute to an effective and efficient order picking process. Most order picking publications treat demand as known in advance. As warehouses accept late orders, the assumption of a constant given demand is questioned in this paper. The objective of this study is to present time series forecasting models that perform well in a zone picking warehouse. A real-life case study demonstrates the value of applying time series forecasting models to forecast the daily number of order lines. The forecast of order lines, along with order pickers’ productivity, can be used by warehouse supervisors to determine the daily required number of order pickers, as well as the allocation of order pickers across warehouse zones. Time series are applied on an aggregated level, as well as on a disaggregated zone level. Both bottom-up and top-down approaches are evaluated in order to find the best-performing forecasting method. [less ▲]

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See detailVitamins in Paediatric Parenteral Nutrition
Bronski, J; Campoy, C; Braegger, C et al

in Clinical Nutrition (in press)

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See detailLe populisme aux Etats-Unis
Jamin, Jérôme ULg

in Revue de la Faculté de Droit de l'Université de Liège (in press)

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See detailThe unexpected discovery of Brucella abortus Buck 19 vaccine in goats from Ecuador underlines the importance of biosecurity measures
Ron-Roman, J; Berkvens, D; Barzallo-Rivadeneira, D et al

in Tropical Animal Health and Production (in press)

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See detailPsychological interventions influence patients' attitudes and beliefs about their chronic pain.
VANHAUDENHUYSE, Audrey ULg; Gillet, Aline; MALAISE, Nicole ULg et al

in Journal of Traditional and Complementary Medicine (in press)

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See detailProjections photographiques et cinéma des premiers temps : La houillère de Gustave Marissiaux et les origines du cinéma minier
Mélon, Marc-Emmanuel ULg

in Intermédialités : Histoire et Théorie des Arts, des Lettres et des Techniques = Intermediality: History and Theory of the Arts, Literature and Technologies (in press)

Les spectacles de projection conçus par Gustave Marissiaux entre 1903 et 1926, en particulier le vaste documentaire intitulé "La houillère" (1905) est ici inscrit dans une histoire sociale des images ... [more ▼]

Les spectacles de projection conçus par Gustave Marissiaux entre 1903 et 1926, en particulier le vaste documentaire intitulé "La houillère" (1905) est ici inscrit dans une histoire sociale des images projetées et mis en rapport avec le cinéma minier des premiers temps [less ▲]

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See detailEarly Detection of University Students with Potential Difficulties
Hoffait, Anne-Sophie ULg; Schyns, Michael ULg

in Decision Support Systems (in press)

Using data mining methods, this paper presents a new means of identifying freshmen's profiles likely to face major difficulties to complete their first academic year. Academic failure is a relevant issue ... [more ▼]

Using data mining methods, this paper presents a new means of identifying freshmen's profiles likely to face major difficulties to complete their first academic year. Academic failure is a relevant issue at a time when post-secondary education is ever more critical to economic success. We aim at early detection of potential failure using student data available at registration, i.e. school records and environmental factors, with a view to timely and efficient remediation and/or study reorientation. We adapt three data mining methods, namely random forest, logistic regression and artificial neural network algorithms. We design algorithms to increase the accuracy of the prediction when some classes are of major interest. These algorithms are context independent and can be used in different fields. Real data pertaining to undergraduates at the University of Liège (Belgium), illustrates our methodology. [less ▲]

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See detailA damage to crack transition model accounting for stress triaxiality formulated in a hybrid non-local implicit discontinuous Galerkin - cohesive band model framework
Leclerc, Julien ULg; Wu, Ling ULg; Nguyen, Van Dung ULg et al

in International Journal for Numerical Methods in Engineering (in press)

Modelling the entire ductile fracture process remains a challenge. On the one hand, continuous damage models succeed in capturing the initial diffuse damage stage but are not able to represent ... [more ▼]

Modelling the entire ductile fracture process remains a challenge. On the one hand, continuous damage models succeed in capturing the initial diffuse damage stage but are not able to represent discontinuities or cracks. On the other hand, discontinuous methods, as the cohesive zones, which model the crack propagation behaviour, are suited to represent the localised damaging process. However, they are unable to represent diffuse damage. Moreover, most of the cohesive models do not capture triaxiality effect. In this paper, the advantages of the two approaches are combined in a single damage to crack transition framework. In a small deformation setting, a non-local elastic damage model is associated with a cohesive model in a discontinuous Galerkin finite element framework. A cohesive band model is used to naturally introduce a triaxiality-dependent behaviour inside the cohesive law. Practically, a numerical thickness is introduced to recover a 3D-state, mandatory to incorporate the in-plane stretch effects. This thickness is evaluated to ensure the energy consistency of the method and is not a new numerical parameter. The traction-separation law is then built from the underlying damage model. [less ▲]

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See detailNo post-no core approach to restore severely damaged posterior teeth: An up to 10-year retrospective study of documented endocrown cases
BELLEFLAMME, Marcia ULg; Geerts, Sabine ULg; LOUWETTE, Marie ULg et al

in Journal of Dentistry (in press)

Objectives The objectives of the present study were to (1) retrospectively evaluate documented cases of ceramic and composite endocrowns performed using immediate dentin sealing (IDS); (2) correlate ... [more ▼]

Objectives The objectives of the present study were to (1) retrospectively evaluate documented cases of ceramic and composite endocrowns performed using immediate dentin sealing (IDS); (2) correlate failures with clinical parameters such as tooth preparation characteristics and occlusal parameters. Methods 99 documented cases of endocrowns were evaluated after a mean observation period of 44.7 ± 34.6 months. A classification of restorations was established in function of the level of damage of residual tooth tissues after preparation, from 1 to 3. Evaluation was performed according to FDI criteria and endodontic outcomes were analyzed. Occlusal risk factors were examined and fractographic analysis was performed in case of fracture. Results 48.4% of patients were shown to present occlusal risk factors. 75.8% of restorations were Class 3 endocrowns. 56.6% were performed on molars, 41.4% on premolars and 2.0% on canines. 84.8% were performed in lithium-disilicate glass-ceramic and 12.1% in Polymer-Infiltrated Ceramic Network (PICN) material. The survival and success rates of endocrowns were 99.0% and 89.9% respectively, while the 10-year Kaplan-Meier estimated survival and success rates were 98.8% and 54.9% respectively. Ten failures were detected: periodontal disease (n = 3), endocrown debonding (n = 2), minor chipping (n = 2), caries recurrence (n = 2) and major fractures (n = 1). Due to the reduced amount of failures, no statistical correlation could be established with clinical parameters. Conclusions Endocrowns were shown to constitute a reliable approach to restore severely damaged molars and premolars, even in the presence of extensive coronal tissue loss or occlusal risk factors, such as bruxism or unfavorable occlusal relationships. Clinical significance Practitioners should consider the endocrown instead of the post and core approach to restore severely damaged non-vital posterior teeth. This minimally invasive solution reduces the risk of catastrophic failures and is easily performed. The use of IDS procedure and lithium-disilicate glass-ceramic as prosthesis material gave very good results. [less ▲]

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See detailVIP: Vortex Image Processing package for high-contrast direct imaging
Gómez González, Carlos ULg; Wertz, Olivier; Absil, Olivier ULg et al

in Astronomical Journal (The) (in press)

We present the Vortex Image Processing (VIP) library, a python package dedicated to astronomical high-contrast imaging. Our package relies on the extensive python stack of scientific libraries and aims to ... [more ▼]

We present the Vortex Image Processing (VIP) library, a python package dedicated to astronomical high-contrast imaging. Our package relies on the extensive python stack of scientific libraries and aims to provide a flexible framework for high-contrast data and image processing. In this paper, we describe the capabilities of VIP related to processing image sequences acquired using the angular di↵erential imaging (ADI) observing technique. VIP implements functionalities for building high-contrast data processing pipelines, encompass- ing pre- and post-processing algorithms, potential sources position and flux estimation, and sensitivity curves generation. Among the reference point-spread function subtraction techniques for ADI post-processing, VIP includes several flavors of principal component analysis (PCA) based algorithms, such as annular PCA and incremental PCA algorithm capable of processing big datacubes (of several gigabytes) on a computer with limited memory. Also, we present a novel ADI algorithm based on non-negative matrix factorization (NMF), which comes from the same family of low-rank matrix approximations as PCA and provides fairly similar results. We showcase the ADI capabilities of the VIP library using a deep sequence on HR8799 taken with the LBTI/LMIRCam and its recently commissioned L-band vortex coronagraph. Using VIP we investigated the presence of additional companions around HR8799 and did not find any significant additional point source beyond the four known planets. VIP is available at http://github.com/vortex-exoplanet/VIP and is accompanied with Jupyter notebook tutorials illustrating the main functionalities of the library. [less ▲]

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See detailL'(ir)responsabilité du pouvoir judiciaire : fondement et mise à l'épreuve de l'immunité judiciaire en droits québécois et belge
Bouhon, Frédéric ULg; Lacroix, Mariève

in Revue de Droit International et de Droit Comparé (in press), 2017/3

Ce long article compare les régimes juridiques belge et québécois sur la question de la responsabilité civile pour les fautes commises par les juges dans l'exercice du pouvoir judiciaire. Bien que les ... [more ▼]

Ce long article compare les régimes juridiques belge et québécois sur la question de la responsabilité civile pour les fautes commises par les juges dans l'exercice du pouvoir judiciaire. Bien que les solutions retenues de part et d’autre de l’Atlantique semblent divergentes a priori – absolutisme de l’immunité du juge au Québec et relativisation de celle-ci en Belgique –, un examen plus approfondi révèle que les incidences pratiques ne sont pas aussi radicalement opposées. Certes, l’État belge peut engager sa responsabilité civile en présence d’une faute du juge, ce qui ne saurait être admis au Québec , mais les modalités de l’action civile que la jurisprudence belge a retenues (spécialement la condition de recevabilité et la notion de faute caractérisée) limitent fortement l’ampleur du contentieux dans ce domaine. Par ailleurs, au Québec, on relève un infléchissement – purement théorique, car aucun cas concret où la responsabilité civile du juge a été retenue n’existe à l’heure actuelle – du principe de l’immunité absolue du juge dans le cadre de sa responsabilité civile personnelle, lorsqu’il agit sans compétence, tout en sachant ne pas avoir compétence d’agir ainsi. [less ▲]

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See detailThe heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization
Genon, Sarah ULg; Reid, Andrew; Li, Hai et al

in NeuroImage (in press)

Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the ... [more ▼]

Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting- state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive- motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro- ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd. [less ▲]

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See detailUltrasonic roll bite measurements in cold rolling - roll stress and deformation
Carretta, Yves; Hunter, Andrew; Boman, Romain ULg et al

in Journal of Materials Processing Technology (in press)

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip ... [more ▼]

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, several online measurements are usually carried out such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area. This paper presents a sensor capable of monitoring roll deformations as well as roll radial stresses in situ and in real time. The sensor emits ultrasonic pulses that reflect from the roll surface. The time-of-flight (ToF) of the pulses is recorded during the testing. The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under different strip elongation. Roll deformation and radial stresses obtained from the experimental data are in good agreement with numerical results computed with a cold rolling model developed in non-linear Finite Element software. [less ▲]

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See detailEntre mutation et métissage Co-construction d’une ethnographie émancipatrice et féministe
Vivas Romero, Maria ULg

in Émulation Revue des Jeunes Chercheuses et chercheurs en sciences sociales (in press)

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See detailSacred Alliance or Pact with the Devil? How and Why Social Enterprises Collaborate with Mainstream Businesses in the Fair Trade Sector
Huybrechts, Benjamin ULg; Nicholls, Alex; Edinger, Katharina

in Entrepreneurship and Regional Development (in press)

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises ... [more ▼]

This paper uses institutional theory to highlight different patterns of cross-sector collaboration from the perspective of social enterprises. Specifically, it explores how and why social enterprises interact with mainstream businesses and to what extent their collaboration patterns reflect a vision of how their social mission should be implemented and institutionalized. The empirical analysis is derived from a qualitative study of ‘fair trade’ – a hybrid model created by social enterprises and using market mechanisms to support small-scale producers in developing countries and to advocate for changes in international trading practices. The findings highlight three strategies used by fair trade social enterprises to manage their interactions with mainstream businesses: sector solidarity, selective engagement, and active appropriation. This paper suggests that each strategy is motivated by a different vision of how best to articulate the social mission of fair trade via specific types of collaborations. It also notes how each vision has a distinct pattern of institutionalization at the field level. This paper adds to the emergent literatures on social enterprise and social entrepreneurship, fair trade, cross-sector collaboration and hybrid organizing. [less ▲]

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See detailA review on early gut maturation and colonization in pigs, including biological and dietary factors affecting gut homeostasis
Everaert, Nadia ULg; Van Cruchten, Steven; Weström, Björn et al

in Animal Feed Science & Technology (in press)

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See detailFusion-based Additive Manufacturing for Processing Aluminum Alloys: State-of-the-Art and Challenges
Mertens, Anne ULg; Delahaye, Jocelyn ULg; Lecomte-Beckers, Jacqueline ULg

in Advanced Engineering Materials (in press)

Starting early 2015, the fusion-based additive manufacturing of Al alloys has been developing at an ever faster pace after undergoing a comparatively slow start with respect to other metallic materials ... [more ▼]

Starting early 2015, the fusion-based additive manufacturing of Al alloys has been developing at an ever faster pace after undergoing a comparatively slow start with respect to other metallic materials. This paper reviews the recent developments with the aim of identifying major challenges and opportunities for future work. Laser Beam Melting proves the most useful technique for the additive fabrication of Al components with strongly out-of-equilibrium microstructures and potentially enhanced mechanical behavior. Laser Cladding is also promising for specific applications such as repairs and coatings. However, a deeper understanding of the thermal history during fabrication is still needed to further optimize the microstructures and usage properties. The design of new high strength alloys and of Al-matrix composites, and the development of better adapted post-processing procedures to take greater advantage of the specificities of fusion-based additive techniques are two other important issues in view of reaching the full potential of additive Al components. [less ▲]

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See detailMapping degenerate vortex states in a kagomé lattice of elongated antidots via scanning Hall probe microscopy
Xue, Cun; Ge, Jun-Yi; He, An et al

in Physical Review. B : Condensed Matter (in press)

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe ... [more ▼]

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe microscopy (SHPM). The observed vortex patterns, at specifi c applied magnetic fi elds, are in good agreement with the confi gurations obtained using time-dependent Ginzburg-Landau (TDGL) simulation. Both results indicate that the long range interaction in this nano-structured superconductor is unable to lift degeneracy between different vortex states and the pattern formation is mainly ruled by the nearest neighbour interaction. This simpli cation allows the identi cation of a set of simple rules characterizing the vortex con gurations. We demonstrated that these rules can explain both the observed vortex distributions and the magnetic fi eld dependent degree of degeneracy. [less ▲]

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See detailMaqriziana XIV: Al-Maqrīzī’s Last Opus (Al-Ḫabar ʿan al-Bašar) and Its Significance for the History of Islam
Bauden, Frédéric ULg

in Journal of the Royal Asiatic Society (in press)

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See detailDisrupted Self in Alzheimer’s disease: beyond midline structures: Commentary on Wong et al.
Genon, Sarah ULg; Salmon, Eric

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (in press)

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See detailImpact of climate change on potential evapotranspiration under a historical and future climate scenario in the Huang-Huai-Hai Plain, China
Liu, Qin; Yan, Changrong; Ju, Hui et al

in Theoretical & Applied Climatology (in press)

Climate change is widely accepted to be one of the most critical problems faced by the Huang-Huai-Hai Plain (3H Plain), which is a region in which there is an over-exploitation of groundwater region and ... [more ▼]

Climate change is widely accepted to be one of the most critical problems faced by the Huang-Huai-Hai Plain (3H Plain), which is a region in which there is an over-exploitation of groundwater region and where future warmer and drought conditions might intensify crop water demand. In this study, the spatiotemporal patterns of ET0 and primary driving meteorological variables were investigated based on a historical and RCP 8.5 scenario daily data set from 40 weather stations over the 3H Plain using linear regression, spline interpolation method, a partial derivative analysis and multivariate regression. The results indicated a negative trend in all the analysis periods (except spring) of the past 54 years of which only summer and the entire year were statistically significant (p < 0.01) with slopes of -1.09 and -1.30 mm·a-1 respectively. In contrast, a positive trend was observed in all four seasons and the entire year under the RCP 8.5 scenario, with the biggest increment equal to 1.36 mm·a-1 in summer and an annual increment of 3.37 mm·a-1. The spatial patterns of the seasonal and annual ET0 exhibited the lowest values in southeastern regions and the highest values in northeastern parts of Shandong Province, probably because of the combined effects of various meteorological variables over the past 54 years. Relative humidity (RH) together with solar radiation (RS) were detected to be the main climatic factors controlling the reduction of ET0 in summer, autumn, and the entire year on the 3H Plain. ET0 in spring was mainly sensitive to changes in RS and RH, whereas ET0 in winter was most sensitive to changes in wind speed (WS) and decreased due to declining RH. Under the future RCP 8.5 scenario, the annual ET0 distribution displays a rich spatial structure with a clear northeast-west gradient and anarea with low values in the southern regions, which is similarly detected in spring and summer. The most sensitive and primary controlling variables with respect to the increment of future ET0 are in the first place RS and then mean temperature in spring, while turn to be mean temperature and then RS in summer. In autumn, future ET0 is most sensitive to RH changes. WS and RH are the controlling variables for ET0 in winter. Annual future ET0 is most sensitive to RH changes and accordingly RS is responsible for the predicted increment of the annual ET0. Better understanding of current and future spatiotemporal patterns of ET0 and of the regional response of ET0 to climate change can contribute to the establishment of a policy to realize a more efficient use of water resources and a sustainable agricultural production in the 3H Plain. [less ▲]

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See detailSpatiotemporal variation of drought characteristics in the context of climate change in the Huang-Huai-Hai Plain, China
Li, Xiang-Xiang; Ju, Hui; Garré, Sarah ULg et al

in Journal of Integrative Agriculture (in press)

Understanding the potential drought characteristics under climate change is essential for reducing vulnerability and establishing adaptation strategies, especially in the Huang-Huai-Hai Plain (3H Plain ... [more ▼]

Understanding the potential drought characteristics under climate change is essential for reducing vulnerability and establishing adaptation strategies, especially in the Huang-Huai-Hai Plain (3H Plain) which is the grain production base in China. In this paper, the variation of drought characteristics including drought event frequency, duration, severity and intensity for the past 50 years (1961-2010) and future scenarios (2010-2099) based on observed meteorological data and RCP 8.5 projections were investigated, respectively. Firstly, the applicability of three climatic drought indices including the Standardized Precipitation Index (SPI), the Standardized Precipitation Evapotranspiration Index based on the Penman–Monteith equation (SPEI-PM) and the Thornthwaite equation (SPEI-TH) were compared in tracing recorded agricultural drought areas. Then, the drought characteristics including drought event, duration, severity and intensity using “run theory” was analyzed for both historical observations and future RCP 8.5 scenarios based on the proper index. Correlation analysis between drought indexes and agricultural drought areas showed that SPEI-PM performed better than SPI and SPEI-TH in the 3H Plain. Based on the results of SPEI-PM, droughts over the past 50 years have experienced reduced drought with shorter durations, and weaker severity and intensity. However, for the future RCP 8.5 scenario, drought is predicted to rise in frequency, duration, severity and intensity from 2010-2099 although drought components during the 2010-2039 were milder compared to historical conditions. This study highlights that the estimations for atmospheric evaporative demand would bring in differences in long term drought trend of drought indexes and consequently the applicability in 3H Plain. The results of this paper can help inform researchers and local policy makers to establish drought risk management strategies. [less ▲]

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See detailEvaluation of the spatial and economic effectiveness of industrial land policies in Northwest Europe
Vandermeer, Marie-Caroline; Halleux, Jean-Marie ULg

in European Planning Studies (in press)

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e ... [more ▼]

This article stems from the discrepancy between the lack of attention paid to industrial land policy by academics and the predominant thought among elected representatives and development agencies, i.e. that industrial land policy plays a key role in the creation of growth and new jobs. The article begins with a reflection on the literature, which stresses the need to develop knowledge on industrial land policies. To help fill this research gap, we have developed an exploratory piece of research on the theme of their spatial and economic effectiveness, on the basis of statistical analyses dedicated to seven countries. As regards spatial effectiveness, the results underline significant national differentials in terms of land consumption on the one hand, while highlighting the economic sprawl that affects France and Belgium on the other hand. As regards economic effectiveness, our results show that the impact of the development of economic estates on growth depends largely on regional contexts. In particular, the “intermediate regions” in western Germany stand out as belonging to a specific context where land policies seem particularly effective from an economic standpoint. By contrast, the economic effectiveness of industrial land policies requires readjustments in most “predominantly rural regions, close to a city”. [less ▲]

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See detailAn active bacterial community linked to high chl-a concentrations in Antarctic winter-pack ice and evidence for the development of an anaerobic sea-ice bacterial community
Eronen-Rasimus, Eeva; Luhtanen, Anne-Mari; Rintala, Janne-Markus et al

in ISME Journal (The) (in press), 1-11

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to ... [more ▼]

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to high (o4 μg l–1) chlorophyll-a (chl-a) concentrations and consequent bacterial production. Typical sea-ice bacterial genera, for example, Octadecabacter, Polaribacter and Glaciecola, often abundant in spring and summer during the sea-ice algal bloom, predominated in the communities. The variability in bacterial community composition in the different ice types was mainly explained by the chl-a concentrations, suggesting that as in spring and summer sea ice, the sea-ice bacteria and algae may also be coupled during the Antarctic winter. Coupling between the bacterial community and sea-ice algae was further supported by significant correlations between bacterial abundance and production with chl-a. In addition, sulphate-reducing bacteria (for example, Desulforhopalus) together with odour of H2S were observed in thick, apparently anoxic ice, suggesting that the development of the anaerobic bacterial community may occur in sea ice under suitable conditions. In all, the results show that bacterial community in Antarctic sea ice can stay active throughout the winter period and thus possible future warming of sea ice and consequent increase in bacterial production may lead to changes in bacteria-mediated processes in the Antarctic sea-ice zone. [less ▲]

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See detailL'Halys chez Hérodote
Leloux, Kevin ULg

in Studia Hercynia (in press)

This paper analyses the Halys River’ description made by Herodotus in his Histories. This study focuses on the several references made by the Father of History in his work. It will examine the part the ... [more ▼]

This paper analyses the Halys River’ description made by Herodotus in his Histories. This study focuses on the several references made by the Father of History in his work. It will examine the part the river took in his vision of the politic, ethnic and geographic state in the historian’s mind and the problems that arise by this presentation. Finally, this article will demonstrate that every crossing of the Halys River made by the Barbarians were a bad omen for the Greeks of Asia Minor and in Greece itself. [less ▲]

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See detailBehaviour and browse species selectivity of heifers grazing in a temperate silvopastoral system
Vandermeulen, Sophie ULg; Ramírez-Restrepo, Carlos Alberto; Marche, Christian et al

in Agroforestry Systems (in press)

In Belgium silvopastoral grazing systems associating trees and pasture are instrumental in enhancing dynamic trade-offs between ruminant farming and habitat improvement. A 130-day study was conducted in ... [more ▼]

In Belgium silvopastoral grazing systems associating trees and pasture are instrumental in enhancing dynamic trade-offs between ruminant farming and habitat improvement. A 130-day study was conducted in Belgium from April to September 2013 to evaluate the effects of browsing a combination of shrubs and trees (i.e. hedge) on the selective behaviour of cattle and to relate these observations to changes in forage nutritive value. Twelve Holstein dairy heifers (Bos taurus; 487 kg) were allocated to either a control ryegrass pasture (i.e. control pasture group; CPG) or a pasture plus unrestricted browsing (i.e. browsing group; BG) of a hedge composed of shrubs and trees. Behaviour and selectivity towards the woody species were recorded for 14h on a daily basis during 3 consecutive days over spring, early summer and late summer. Leaves and stems of woody species and faecal samples were collected during each season to analyse their nutritive value and predict the dry matter intake by means of near infrared reflectance spectroscopy. Integrating shrubs and trees along a pasture influenced the heifers’ behaviour and BG heifers spent 19.3, 5.9 and 5.4% of their time browsing during spring, and early and late summer, respectively (P < 0.001). This behaviour was correlated to the pre-grazing pasture biomass (r=0.50; P < 0.001). Compared with the summer seasons, the greater browsing activity in spring was associated with higher plant feeding value. Overall, the most ingested species were Carpinus betulus, Cornus sanguinea, Corylus avellana and Crataegus monogyna. It was concluded that cattle use a significant time budget for browsing on temperate ryegrass pasture but further research is required to investigate potential benefits of silvopastoral systems in Belgium. [less ▲]

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See detailThe Forgotten History of Repetitive Audio Technologies
Levaux, Christophe ULg

in Organised Sound (in press)

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See detailSerogroups and genotypes of Leptospira 1 spp. strains from bovine aborted fetuses
Delooz, L; Czaplicki, G; Grégoire, F et al

in Transboundary and Emerging Diseases (in press)

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See detailDual action of neuro-estrogens in the regulation of male sexual behavior
Cornil, Charlotte ULg; de Bournonville, Catherine

in General and Comparative Endocrinology (in press)

Estrogens derived from brain testosterone aromatization (neuro-estrogens) are critical for the activation of male sexual behavior. Their effects on this behavior are typically associated with long-term ... [more ▼]

Estrogens derived from brain testosterone aromatization (neuro-estrogens) are critical for the activation of male sexual behavior. Their effects on this behavior are typically associated with long-term changes in circulating levels of testosterone and the transcriptional activity of their liganded nuclear receptors. According to this view, neuro-estrogens would prime the neural circuits controlling the long-term expression of behavior, which would then be acutely regulated by neurotransmitter systems conveying information from the social environment. In parallel, neuro-estrogens are also able to produce much faster effects than previously anticipated. Our recent investigations in Japanese quail revealed an interesting dichotomy in the regulation of male sexual behavior by membrane- and nuclear-initiated estrogen signaling providing respectively an acute modulation of sexual motivation and a long-term control of the capacity to display the copulatory sequence. In parallel, a similar dichotomy applies to the regulation of brain aromatase whose expression depends on the transcriptional activity of testosterone metabolites while its enzymatic activity is rapidly regulated in a region- and context-dependent manner. Recent evidences suggest that rapid changes in sexual motivation result from rapid changes in local estrogen production. Together, these data support the idea that the acute regulation of some aspects of male sexual behavior depends not only on classical neurotransmitter systems, but also on rapid and spatially restricted changes in local estrogen availability. The existing literature suggests that this acute regulation by neuro-estrogens of the motivational aspects of behavior could be generalized to other systems such as singing behavior in songbirds. [less ▲]

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See detailImproving pedestrian detection using motion-guided filtering
Wang, Yi; Pierard, Sébastien ULg; Su, Song-Zhi et al

in Pattern Recognition Letters (in press)

In this letter, we show how a simple motion-guided nonlinear filter can drastically improve the accuracy of several pedestrian detectors. More specifically, we address the problem of how to pre-filter an ... [more ▼]

In this letter, we show how a simple motion-guided nonlinear filter can drastically improve the accuracy of several pedestrian detectors. More specifically, we address the problem of how to pre-filter an image so almost any pedestrian detector will see its false detection rate decrease. First, we roughly identify moving pixels by cumulating their temporal gradient into a motion history image (MHI). The MHI is then used in conjunction with a nonlinear filter to filter out background details while leaving untouched foreground moving objects. We also show how a feedback loop as well as a merging procedure between the filtered and the unfiltered frames can further improve results. We tested our method on 26 videos from 6 categories. The results show that for a given miss rate, filtering out background details reduces the false detection rate by a factor of up to 69.6 times. Our method is simple, computationally light, and can be implemented with any pedestrian detector. Code is made publicly available at: https://bitbucket.org/wany1601/pedestriandetection. [less ▲]

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See detailA method for independent component graph analysis of resting-state fMRI. Brain and Behavior 2017, in press
Ribeiro de Paula, Demetrius; Ziegler, Erik; Abeyasinghe, P et al

in Brain and Behavior (in press)

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See detailVieillir en bonne santé dans une société âgiste...
Adam, Stéphane ULg; Missotten, Pierre ULg; Flamion, Allison ULg et al

in NPG. Neurologie - Psychiatrie - Gériatrie (in press)

La vision actuelle du vieillissement est principalement négative, teintée du phénomène d’âgisme (c’est-à-dire toutes les formes de discrimination, de ségrégation ou de mépris fondées sur l’âge). Une telle ... [more ▼]

La vision actuelle du vieillissement est principalement négative, teintée du phénomène d’âgisme (c’est-à-dire toutes les formes de discrimination, de ségrégation ou de mépris fondées sur l’âge). Une telle image de la vieillesse n’est pas anodine. Dans cet article, nous passerons en revue les manifestations de l’âgisme dans notre vie quotidienne, ses origines, ses implications sur nos attitudes, de même que les conséquences qui en résultent pour les personnes âgées. Nous discuterons également de certains enjeux cliniques et éthiques en lien avec ces attitudes âgistes [less ▲]

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See detailRôle et langue de Tchantchès dans les représentations en castelets des romans de chevalerie : le cas des Quatre fils Aymon
Baiwir, Esther ULg; Impe, Anaëlle

in Enquêtes du Musée de la Vie Wallonne (in press)

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du ... [more ▼]

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du répertoire liégeois ? Quels sont ses moyens d'action, mais également ses modes d'expression ? Divers registres de langue apparaissent au fil des spectacles ; quels sont ceux prêtés à notre héros ? Et surtout, ce rôle et cette langue ont-ils évolué au fil du temps ? C’est à ces quelques questions que nous tentons de répondre, en observant les différentes interventions de Tchantchès dans les réécritures des aventures des quatre fils Aymon, l’une des œuvres les plus anciennes et les plus fréquemment jouées dans les théâtres liégeois dévolus aux comédiens de bois. [less ▲]

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See detailSerum Creatinine: Not So Simple!
DELANAYE, Pierre ULg; Cavalier, Etienne ULg; Pottel, Hans

in Nephron (in press)

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological ... [more ▼]

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDMS traceability), analytical interferences, analytical coefficient of variation (CV), biological CV and critical difference. Because the relationship between serum creatinine and glomerular filtration rate is hyperbolic, all these CVs will impact not only the precision of serum creatinine but still more the precision of different creatinine-based equations, especially in low or normal-low creatinine levels (or high or normal-high glomerular filtration rate range). [less ▲]

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See detailElucidating the mechanisms driving the ageing of porous hollow PtNi/C nanoparticles by the means of COads stripping
Asset, Tristan ULg; Chattot, Raphaël; Drnec, Jakub et al

in ACS Materials & Interfaces (in press)

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See detailObjet et pratiques sémiotiques : les enjeux médiatiques du support photographique
Honba Honba, Cédric ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press)

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See detailFocus sur les lymphocytes T dans la maladie du greffon contre l'hôte après allogreffe de cellules soucges hématopoïétiques: implications pour de nouvelles stratégies de prévention
Vrancken, L; Delens, Loïc ULg; BEGUIN, Yves ULg et al

in Oncol. Hematol. (in press)

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches ... [more ▼]

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches hématopoïétiques. Bien que la physiopathologie de celle-ci ne reste que partiellement élucidée à ce jour, il est classiquement admis que les lymphocytes T (LT) jouent un rôle important dans son processus biologique. Les progrès récents de l’immunologie des LT dans la GVHa ont permis de diversifier les pistes visant à prévenir la survenue de cette complication post-greffe. Plusieurs approches sont en cours d’exploration dans des essais cliniques avec des résultats encourageant tels que la manipulation ex vivo des LT avant leur transfert chez le patient afin de leur faire exprimer des gènes suicide, l’élimination in vivo des LT proliférant directement après la greffe, l’inhibition de l’activation des LT en interférant avec les voies de signalisation en aval du TCR ou celles induites par les cytokines, l’induction de l’anergie des LT en bloquant les signaux de costimulation, le blocage de l’adressage des LT vers les organes lymphoïdes secondaires et les tissus cibles, la promotion de l’immunotolérance par la perfusion de lymphocytes T régulateurs ou par l’utilisation d’agents favorisant leur différenciation et leurs fonctions in vivo et la modulation de l’expression génique des cellules immunitaires par des modulateurs épigénétiques. Outre la prévention de la GVHa, le défi des nouvelles stratégies consiste également à ne pas compromettre l’effet bénéfique de la greffe contre la tumeur ni la reconstitution des défenses anti-infectieuses. [less ▲]

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See detailThe miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development
Van Den Ackerveken, Priscilla ULg; Mounier, Anaïs ULg; Huyghe, Aurélia et al

in Cell Death & Differentiation (in press)

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See detailRimbaud flâneur
Saint-Amand, Denis ULg

in Francofonia (in press)

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See detailEtre avec par corps. L'expérience du commun sur un plateau de théâtre
Servais, Véronique ULg; Brahy, Rachel ULg

in Recherches en Communication (in press)

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See detailCarbohydrates in Paediatric Parenteral Nutrition
Mesotten, D; Joosten, K; van Kempen, A et al

in Clinical Nutrition (in press)

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See detailVisualiser la variation et le changement valenciel: structure des compléments datifs dans l’histoire du français
Mazziotta, Nicolas ULg

in Linguisticae Investigationes (in press)

Il est possible de modéliser la variation et le changement valenciel à l'aide des structures formelles que nous nommons _polygraphes_. Ces derniers étendent les arbres syntaxiques dépendanciels en ... [more ▼]

Il est possible de modéliser la variation et le changement valenciel à l'aide des structures formelles que nous nommons _polygraphes_. Ces derniers étendent les arbres syntaxiques dépendanciels en autorisant des relations à porter sur d'autres relations. En prenant l'exemple de l'expression prépositionnelle ou non du datif en ancien français et en français moderne (complément des verbes _donner_, _aider_, et _pardonner_), nous montrons comment les polygraphes peuvent être employés pour montrer géométriquement la différence entre une préposition obligatoire et une préposition facultative. Le potentiel de ces structures permet également de visualiser l'évolution et de comparer le comportement des lexèmes. [less ▲]

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See detailCritical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field
Cailletaud, Johan ULg; De Bleye, Charlotte ULg; Dumont, Elodie ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (in press)

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is ... [more ▼]

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is more sensitive allowing its use for the detection and the quantification of low-dose substances contained in pharmaceutical samples. However, the analytical performance of SERS is limited due to the difficulty to implement a quantitative methodology correctly validated. Nevertheless, some studies reported the development of SERS quantitative methods especially in pharmaceutical approaches. In this context, this review presents the main concepts of the SERS technique. The different steps that need to be applied to develop a SERS quantitative method are also deeply described. The last part of the present manuscript gives a critical overview of the different SERS pharmaceutical applications that were developed for a non-exhaustive list of pharmaceutical compounds with the aim to highlights the validation criteria for each application. [less ▲]

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See detailThe effect of spaceflight and microgravity on the human brain
Van Ombergen, Angelique; Demertzi, Athina ULg; Tomilovskaya et al

in Journal of Neurology (in press)

Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental ... [more ▼]

Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental effects on human physiology. Although research has focused on the cardiovascular and musculoskeletal system in particular, the exact impact of spaceflight on the human central nervous system remains to be determined. Previous studies have reported psychological problems, cephalic fluid shifts, neurovestibular problems, and cognitive alterations, but there is paucity in the knowledge of the underlying neural substrates. Previous space analogue studies and preliminary spaceflight studies have shown an involvement of the cerebellum, cortical sensorimotor, and somatosensory areas and the vestibular pathways. Extending this knowledge is crucial, especially in view of long-duration interplanetary missions (e.g., Mars missions) and space tourism. In addition, the acquired insight could be relevant for vestibular patients, patients with neurodegenerative disorders, as well as the elderly population, coping with multisensory deficit syndromes, immobilization, and inactivity. [less ▲]

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See detailSocial sustainability assessments in the biobased economy: Towards a systemic approach
Rafiaani, Parisa ULg; Kuppens, Tom; Van Dael, Miet et al

in Renewable & Sustainable Energy Reviews (in press)

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a ... [more ▼]

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a modified systemic approach for a social sustainability impact assessment of the biobased economy, based on a review on the common methodologies for assessing social impacts. Accordingly, the proposed approach follows the four general iterative steps of social life cycle analysis (SLCA) as it considers all life cycle phases of the biobased economy. The systemic approach considers the potential social impacts on local communities, workers, and consumers as the main three groups of the stakeholders. The review showed that the most common social indicators for inventory analysis within the biobased economy include health and safety, food security, income, employment, land- and worker-related concerns, energy security, profitability, and gender issues. Multi-criteria decision analysis (MCDA) was also highlighted as the broadly utilized methodology for aggregating the results of impact assessments within the biobased economy. Taking a life cycle perspective, this study provides a holistic view of the full sustainability of research, design, and innovation in the biobased economy by suggesting the integration of the social aspects with techno-economic and an environmental life cycle assessment. Our proposed systemic approach makes possible to integrate the social impacts that are highly valued by the affected stakeholders into the existing sustainability models that focus only on environmental and techno-economic aspects. We discuss the steps of the proposed systemic approach in order to identify the challenges of applying them within the biobased economy. These challenges refer mainly to the definition of the functional unit and system boundaries, the selection and the analysis of social indicators (inventory analysis), the aggregation of the inventory to impact categories, and the uncertainties associated with the social sustainability evaluation. The result of this review and the proposed systemic approach serve as a foundation for industry and policy makers to gain a better insight into the importance of social sustainability impacts assessment within the biobased economy. [less ▲]

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See detailFigement, langage et didactique du français langue première
Steffens, Marie ULg

in Langues et Linguistique (in press), (36),

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See detailLes troubles du sommeil chez l'enfant autiste, quel rôle pour le pédopsychiatre?
Abate Ekollo, Joëlle; Malchair, Alain ULg

in Acta Psychiatrica Belgica (in press)

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants ... [more ▼]

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants souffrant de troubles du spectre autistique présentent un déficit de sommeil, qui peut durer jusqu’à l’adolescence. Les troubles du spectre autistique comportent des comorbidités multiples, dont des altérations du sommeil. Ils sont importants à caractériser dans cette population, car ils peuvent avoir un impact négatif sur les comportements diurnes. Par ailleurs, ils entrainent souvent des difficultés au sein de la famille. La prise en charge doit avant tout prendre en compte le contexte environnemental afin d’améliorer les habitudes et l’hygiène du sommeil. Des questionnaires ainsi que des agendas de sommeil ont été remplis par des parents afin de démontrer l’importance d’une évaluation et d’une prise en compte des troubles du sommeil chez les enfants souffrant d’autisme en consultation pédopsychiatrique. [less ▲]

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See detailVenous Access for Paediatric Parenteral Nutrition
Kolacek, S; Puntis, J; Hojsak, I et al

in Clinical Nutrition (in press)

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See detailThe Gravity of International Crimes as a Challenge to the (Full) Protection of Human Rights before International Criminal Tribunals? A Strasbourg Perspective
Deprez, Christophe ULg

in Nordic Journal of International Law (in press)

While it goes undisputed that international criminal tribunals (ICTs) are, in general terms, bound to respect human rights standards, there is no consensus on whether their obligations should be identical ... [more ▼]

While it goes undisputed that international criminal tribunals (ICTs) are, in general terms, bound to respect human rights standards, there is no consensus on whether their obligations should be identical in scope to those of national criminal tribunals. Most commentators seem to value the idea of equality in protection for international and domestic defendants alike. Yet, according to others, the human rights obligations of ICTs should be contextualised, that is, adapted to the specificities of international justice – and most critically to the gravity of international crimes. This article seeks to shed some light on this debate. It does so, in particular, by pointing out the intrinsic flexibility of human rights, and by drawing on the practice of the European Court of Human Rights with respect to gravity-based contextualism. [less ▲]

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See detailA multifractal formalism for non-concave and non-increasing spectra: the leaders profile method
Esser, Céline ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

in Applied & Computational Harmonic Analysis (in press)

We present an implementation of a multifractal formalism based on the types of histogram of wavelet leaders. This method yields non-concave spectra and is not limited to their increasing part. We show ... [more ▼]

We present an implementation of a multifractal formalism based on the types of histogram of wavelet leaders. This method yields non-concave spectra and is not limited to their increasing part. We show both from the theoretical and from the applied points of view that this approach is more e cient than the wavelet-based multifractal formalisms previously introduced. [less ▲]

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See detailIncreased antimicrobial resistance in a novel CMY-54 AmpC-type enzyme with a GluLeu217-218 insertion in the Ω-loop
Pérez-Llarena, Francisco José; Vázquez-Ucha, Juan Carlos; Kerff, Frédéric ULg et al

in Microbial Drug Resistance : Mechanism, Epidemiology, & Disease (in press)

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See detailDeep imaging search for planets forming in the TW Hya protoplanetary disk with the Keck/NIRC2 vortex coronagraph
Ruane, G.; Mawet, D.; Kastner, J. et al

in Astronomical Journal (The) (in press)

Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic ... [more ▼]

Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic imaging observations to search for accreting planets especially within dust gaps previously detected in scattered light and submm-wave thermal emission. Three nights of observations with the Keck/NIRC2 vortex coronagraph in $L^\prime$ (3.4-4.1$\mu$m) did not reveal any statistically significant point sources. We thereby set strict upper limits on the masses of non-accreting planets. In the four most prominent disk gaps at 24, 41, 47, and 88 au, we obtain upper mass limits of 1.6-2.3, 1.1-1.6, 1.1-1.5, and 1.0-1.2 Jupiter masses ($M_J$) assuming an age range of 7-10 Myr for TW Hya. These limits correspond to the contrast at 95\% completeness (true positive fraction of 0.95) with a 1\% chance of a false positive within $1^{\prime\prime}$ of the star. We also approximate an upper limit on the product of planet mass and planetary accretion rate of $M_p\dot{M}\lesssim10^{-8} M_J^2/yr$ implying that any putative $\sim0.1 M_J$ planet, which could be responsible for opening the 24 au gap, is presently accreting at rates insufficient to build up a Jupiter mass within TW Hya's pre-main sequence lifetime. [less ▲]

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See detailOn the Zero Defect Conjecture
Labbé, Sébastien ULg; Starosta, Stepan; Pelantova, Edita

in European Journal of Combinatorics (in press)

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See detailMulti-temporal monitoring of a regional riparian buffer network (>12,000 km) with LiDAR and photogrammetric point clouds
Michez, Adrien ULg; Piégay, Hervé; Lejeune, Philippe ULg et al

in Journal of Environmental Management (in press)

Riparian buffers are of major concern for land and water resource managers despite their relatively low spatial coverage. In Europe, this concern has been acknowledged by different environmental ... [more ▼]

Riparian buffers are of major concern for land and water resource managers despite their relatively low spatial coverage. In Europe, this concern has been acknowledged by different environmental directives which recommend multi-scale monitoring (from local to regional scales). Remote sensing methods could be a cost-effective alternative to field-based monitoring, to build replicable “wall-to-wall” monitoring strategies of large river networks and associated riparian buffers. The main goal of our study is to extract and analyze various parameters of the riparian buffers of up to 12,000 km of river in southern Belgium (Wallonia) from three-dimensional (3D) point clouds based on LiDAR and photogrammetric surveys to i) map riparian buffers parameters on different scales, ii) interpret the regional patterns of the riparian buffers and iii) propose new riparian buffer management indicators. We propose different strategies to synthesize and visualize relevant information at different spatial scales ranging from local (<10 km) to regional scale (>12,000 km). Our results showed that the selected parameters had a clear regional pattern. The reaches of Ardenne ecoregion have channels with the highest flow widths and shallowest depths. In contrast, the reaches of the Loam ecoregion have the narrowest and deepest flow channels. Regional variability in channel width and depth is used to locate management units potentially affected by human impact. Riparian forest of the Loam ecoregion is characterized by the lowest longitudinal continuity and mean tree height, underlining significant human disturbance. As the availability of 3D point clouds at the regional scale is constantly growing, our study proposes reproducible methods which can be integrated into regional monitoring by land managers. With LiDAR still being relatively expensive to acquire, the use of photogrammetric point clouds combined with LiDAR data is a cost-effective means to update the characterization of the riparian forest conditions. [less ▲]

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See detailArtù italiano e iberico. Appunti in margine ai volumi VII e VIII di ALMA
Morato, Nicola ULg

in Revista de Literatura Medieval (in press), 28

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See detailStandard versus individualized parenteral nutrition
Riskin, A; Picaud, J-C; Shamir, R et al

in Clinical Nutrition (in press)

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See detailPilgrimage Certificates from the Mamluk Period: New Data
Bauden, Frédéric ULg

in Bulletin of the School of Oriental and African Studies (in press)

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See detailLa chapelle Sainte-Pétronille (Bargème, France), témoin d’une apparition moustérienne dans les préalpes nord-varoises
Marzin, Sébastien; Purdue, Louise; Tomasso, Antonin ULg et al

in Bulletin du Musée d'Anthropologie Préhistorique de Monaco (in press)

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