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See detailRethinking Vulnerability Analysis and Governance with Emphasis on a Participatory Approach
Rossignol, Nicolas ULg; Delvenne, Pierre ULg; Turcanu, Catrinel

in Risk Analysis : An Official Publication of the Society for Risk Analysis (in press)

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An ... [more ▼]

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An analysis of the literature on vulnerability analysis allows us to formulate a threefold critique: first, vulnerability analysis has been treated separately in the natural and the technological hazards fields. This separation prevents vulnerability to unleash the full range of its potential, as it constraints appraisals into artificial categories and thus already closes down the outcomes of the analysis. Second, vulnerability analysis focused on assessment tools that are mainly quantitative, whereas qualitative appraisal is a key to assessing vulnerability in a comprehensive way and to informing policy-making. Third, a systematic literature review of case studies reporting on participatory approaches to vulnerability analysis allows us to argue that participation has been important to address the above, but it remains too closed down in its approach and would benefit from embracing a more open, encompassing perspective. Therefore, we suggest rethinking vulnerability analysis as one part of a dynamic process between opening-up and closing-down strategies, in order to support a vulnerability governance framework. [less ▲]

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See detailBrazil – EU Partnership: from high expectations to limited results
Santander, Sébastian ULg; Saraiva, Miriam

in European Journal of International Relations (in press)

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See detailEL TLC UE – Colombia – Perú y la integración regional latinoamericana. ¿Hacia una norteamericanización de la estrategia interregional europea?
Parra Santamaria, Lusmiriam Andrea ULg

in Comentario Internacional (in press)

This document compares the contents of the Free Trade Agreements (FTA) that have been signed by the European Union and by the United States with Colombia. It analyses them from a perspective that ... [more ▼]

This document compares the contents of the Free Trade Agreements (FTA) that have been signed by the European Union and by the United States with Colombia. It analyses them from a perspective that characterizes FTAs into “WTO-extra” and “WTO-plus” agreements. By this analysis, an “Americanization” of the European interregional strategy is partially verified. Nevertheless, this “Americanization” appears to be partial, due to the inclusion of “regional integration” as a transversal theme in European FTA. [less ▲]

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See detail65e Session de la SIHDA
Cavalleri, Vanessa ULg

in Index – Quaderni camerti di studi romanistici (in press)

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See detailRôle et langue de Tchantchès dans les représentations en castelets des romans de chevalerie : le cas des Quatre fils Aymon
Baiwir, Esther ULg; Impe, Anaëlle

in Enquêtes du Musée de la Vie Wallonne (in press)

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du ... [more ▼]

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du répertoire liégeois ? Quels sont ses moyens d'action, mais également ses modes d'expression ? Divers registres de langue apparaissent au fil des spectacles ; quels sont ceux prêtés à notre héros ? Et surtout, ce rôle et cette langue ont-ils évolué au fil du temps ? C’est à ces quelques questions que nous tentons de répondre, en observant les différentes interventions de Tchantchès dans les réécritures des aventures des quatre fils Aymon, l’une des œuvres les plus anciennes et les plus fréquemment jouées dans les théâtres liégeois dévolus aux comédiens de bois. [less ▲]

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See detailMulticenter implementation of geriatric assessment in Belgian patients with cancer: A survey on treating physicians' general experiences and expectations.
Kenis, Cindy; Heeren, Pieter; Bron, Dominique et al

in Journal of geriatric oncology (in press)

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A ... [more ▼]

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A survey was carried out in 9 Belgian hospitals, which participated in a national GA implementation project focusing on older patients with cancer. A newly developed questionnaire was completed by their treating physicians. Data collection comprised of reviewing hospital data, general respondent data, and treating physicians' general experiences and expectations regarding GA. Descriptive statistics were calculated. RESULTS: Eighty-two physicians from 9 hospitals participated. The GA team composition can vary substantially, with a nurse as core member. Ideally, all older patients with cancer in whom a treatment decision is necessary, should benefit from the GA. Nearly all GA domains are reported as very important. Availability of GA results can be improved. Treating physicians want geriatricians to coordinate geriatric recommendations related to the identified GA problems, and expect from trained healthcare workers (THCWs) to collect GA data, to report GA results, and to follow-up the implementation of geriatric recommendations. CONCLUSION: This study identifies relevant information for improving the implementation of GA in older patients with cancer in Belgium and reveals priorities for a THCW from the treating physician's point of view. To increase the effectiveness of GA, further efforts are needed to improve the implementation of geriatric recommendations. [less ▲]

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See detailMultiscale modelling framework for the fracture of thin brittle polycrystalline films - Application to polysilicon
Mulay, Shantanu; Becker, Gauthier ULg; Vayrette, Renaud et al

in Computational Mechanics (in press)

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability ... [more ▼]

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability. The effect of the orientation of grains on the fracture behaviour of polycrystalline silicon is investigated out of the several factors. This is achieved, firstly, by identifying the statistical variation of the fracture strength and critical strain energy release rate, at the nanoscopic scale, over a thin freestanding polycrystalline silicon film, having mesoscopic scale dimensions. The fracture stress and strain at the mesoscopic level are found to be closely matching with uniaxial tension experimental results. Secondly, the polycrystalline silicon film is considered at the continuum MEMS scale, and its fracture behaviour is studied by incorporating the nanoscopic scale effect of grain orientation. The entire modelling and simulation of the thin film is achieved by combining the discontinuous Galerkin method and extrinsic cohesive law describing the fracture process. [less ▲]

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See detailApport de la musculation en sport collectifamateur : exemple du handball féminin
Jidovtseff, Boris ULg; Frère, Pauline; Theunissen, Catherine ULg

in Science & Sports (in press)

Introduction. — The aim of the study was to verify, in a non-professional handball female, if theintroduction of two short workouts per week during all season has a positive impact on muscularperformance ... [more ▼]

Introduction. — The aim of the study was to verify, in a non-professional handball female, if theintroduction of two short workouts per week during all season has a positive impact on muscularperformance.Methods. — Eighteen female playing handball at the top Belgian level were monitored duringthe complete season. Ten of these girls (‘‘Muscu’’ group) achieved, in addition to their usualtraining, two short (30 minutes) strength training sessions weekly. The other (‘‘Control’’ group)followed the usual training, without any strength training session. A battery of tests (leg power,arm power, vertical jump, sprint, throwing, flexibility) has been set up to four times during theseason to follow up muscular performance.Results. — According to the literature, the ‘‘Control’’ group showed any change in performanceduring the year. By contrast, ‘‘Muscu group results demonstrated that the short strength trai-ning program was efficient, with significant improvements in leg power (P < 0.005) and sprint(P < 0.05) tests. Increase in vertical jump was very close to the level of significance (P = 0.06).Arms power did not improve but appeared to be superior in the ‘‘Muscu’’ group in comparisonwith ‘‘Control’’ at the end of the season, which was not the case at the beginning.© 2013 Elsevier Masson SAS. All rights reserved. [less ▲]

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See detailMeteorological variation in daily travel behaviour: evidence from revealed preference data from the Netherlands
Creemers, Lieve; Wets, Geert; Cools, Mario ULg

in Theoretical & Applied Climatology (in press)

This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation ... [more ▼]

This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation (trip motives) and daily modal choices in the Netherlands. To this end, data from the Dutch National Travel Household Survey of 2008 were matched to hourly weather data provided by the Royal Dutch Meteorological Institute and were complemented with thermal indices to indicate the level of thermal comfort and additional variables to indicate the seasonality of the weather conditions. Two multinomial logit–generalised estimation equations (MNL-GEE) models were constructed, one to assess the impact of weather conditions on trip motives and one to assess the effect of weather conditions on modal choice. The modelling results indicate that, depending on the travel attribute of concern, other factors might play a role. Nonetheless, the thermal component, as well as the aesthetical component and the physical component of weather play a significant role. Moreover, the parameter estimates indicate significant differences in the impact of weather conditions when different time scales are considered (e.g. daily versus hourly based). The fact that snow does not play any role at all was unexpected. This finding can be explained by the relatively low occurrence of this weather type in the study area. It is important to consider the effects of weather in travel demand modelling frameworks because this will help to achieve higher accuracy and more realistic traffic forecasts. These will in turn allow policy makers to make better long-term and short-term decisions to achieve various political goals, such as progress towards a sustainable transportation system. Further research in this respect should emphasise the role of weather conditions and activityscheduling attributes. [less ▲]

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See detailMagie et pharmacopée : l’utilisation des végétaux dans les papyrus iatromagiques grecs
de Haro Sanchez, Magali ULg

in Mythos (in press)

The iatromagical papyri, subgenus of the magical papyri, come from Egypt. From the 1st BC to AD the 7th, they appear in the form of formularies, spells copied from them, amulets and a private letter. For ... [more ▼]

The iatromagical papyri, subgenus of the magical papyri, come from Egypt. From the 1st BC to AD the 7th, they appear in the form of formularies, spells copied from them, amulets and a private letter. For many years, the study of these texts has been part of a research program of the Centre de Documentation de Papyrologie Littéraire (CeDoPaL) of the University of Liège. We will present here the results from the analysis of the content of the prescriptions with plants attested in the Greek iatromagical formularies. [less ▲]

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See detailThe RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice
Singh, Maneesh; Singh, Pratibha; Vaira, Dolores et al

in European Journal of Clinical Investigation (in press)

Background Increased intracellular concentration of cyclic AMP (cAMP) in T cells is associated with various immunodeficiency conditions including human immunodeficiency virus (HIV) infection. Several ... [more ▼]

Background Increased intracellular concentration of cyclic AMP (cAMP) in T cells is associated with various immunodeficiency conditions including human immunodeficiency virus (HIV) infection. Several reports indicate a critical role of activated protein kinase A (PKA) in the susceptibility of cells to HIV infection. We have used a cell permeable, stable peptidomimetic version (P3) of the RI-anchoring disruptor (RIAD), which prevents PKA interaction with A-kinase-anchoring proteins (AKAPs). It is known that RIAD peptide abrogates effects of localized cAMP signalling through anchored type I PKA in lymphocytes and prevents murine AIDS (MAIDS) infection when expressed as a transgene in mice. Methods and Results In vitro HIV-infected human peripheral blood mononuclear cells (PBMCs) show reduced levels of p24 and intracellular cAMP in T cells when treated with RIAD peptidomimetic (RIAD-P3). Humanized NOD/SCID/IL2cnull (NSG) mice infected with HIV-1 JRCSF and treated with RIAD-P3 (3􏰀5 mg) once every 2 weeks showed significantly reduced levels of viral load at +28, +42 and +56 days and increased CD4 numbers at +56 days after the start of treatment. RIAD-P3-treated humanized mice had lower levels of intracellular cAMP in T cells sorted from splenocytes. Conclusions Treatment with RIAD-P3 limits HIV-1 viral replication and stabilizes CD4 levels by mechanisms involving cAMP/PKA-I pathway in human PBMCs and humanized NSG mice. [less ▲]

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See detailOsteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Endocrine (in press)

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of ... [more ▼]

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they could have deleterious effects on the bone. Evidence from longitudinal, crosssectional, and prospective cohort studies suggests that the use of antidepressants at therapeutic doses is associated with decreased bone mineral density and increased fracture risk. The association between SSRIs use and fracture risk could potentially differ depending on dose, exposure duration, time of exposure, age, or sex. However, the risk of fracture declined rapidly after discontinuation of use of SSRIs. The evidence now seems sufficient to consider adding SSRIs to the list of medications that contribute to osteoporosis. In practice, assessment of risk factor for osteoporosis or fractures could be made taking into account age, gender, duration, and severity of depression, length of SSRI treatments, and other concurrent risk factors. [less ▲]

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See detailPour une bibliographie raisonnée sur la restauration et la conservation des papyrus
de Haro Sanchez, Magali ULg; Ricciardetto, Antonio ULg

in Studi di Egittologia e di Papirologia (in press)

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See detailThe effect of melody and technique on the singing voice accuracy of trained singers
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Logopedics, Phoniatrics, Vocology (in press)

A previous study highlighted the effect of vocal technique on the singing voice accuracy of trained singers (1). The intervals' precision between the notes of the tune was altered when the singers used ... [more ▼]

A previous study highlighted the effect of vocal technique on the singing voice accuracy of trained singers (1). The intervals' precision between the notes of the tune was altered when the singers used Western operatic singing technique. In order to better understand these results, we have recorded two different melodies sung with two different vocal techniques. A large panel of trained singers (N = 50) participated in the study. The analytical method described in the reference paper (1) has been applied. The results confirm the effect of vocal technique on the vocal accuracy of trained singers. In addition, these results provide an answer about the melodic effect and guide future work on the perception process of operatic voices. [less ▲]

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See detailMartin Heidegger, Extrait du dernier cours de Marbourg
Pieron, Julien ULg

in Philosophie (in press)

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See detailTrajectory-Based Supplementary Damping Control for Power System Electromechanical Oscillations
Wang, Da ULg; Glavic, Mevludin ULg; Wehenkel, Louis ULg

in IEEE Transactions on Power Systems (in press)

This paper considers a trajectory-based approach to determine control signals superimposed to those of existing controllers so as to enhance the damping of electromechanical oscillations. This approach is ... [more ▼]

This paper considers a trajectory-based approach to determine control signals superimposed to those of existing controllers so as to enhance the damping of electromechanical oscillations. This approach is framed as a discrete-time, multi-step optimization problem which can be solved by model-based and/or by learning-based methods. This paper proposes to apply a model-free tree-based batch mode Reinforcement Learning (RL) algorithm to perform such a supplementary damping control based only on information collected from observed trajectories of the power system. This RL-based supplementary damping control scheme is first implemented on a single generator and then several possibilities are investigated for extending it to multiple generators. Simulations are carried out on a 16-generators medium size power system model, where also possible benefits of combining this RL-based control with Model Predictive Control (MPC) are assessed. [less ▲]

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See detailGenetic parameters for mid-infrared methane indicators based on milk fatty acids in dairy cows
Kandel, Purna Bhadra ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Journal of Applied Animal Research (in press)

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not ... [more ▼]

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not currently available. The mid-infrared (MIR) prediction of milk fatty acids is relevant in this context. Five MIR methane indicators were derived from the literature and were calibrated from 600 samples analyzed by gas chromatography. Genetic parameters for these traits were estimated using single trait random regression test-day models from 619,265 records collected from 2007 to 2011 on 71,188 Holstein cows in their first three lactations. For the published indicator showing the highest relationship with the methane data (R2 = 0.88), the average daily heritability was 0.34±0.01, 0.37±0.01 and 0.34±0.01 for the first three lactations, respectively. The methane emission (g/day) was increased from beginning of lactation, reached at the highest in peak of lactation and decreased towards end of lactation. The largest differences between estimated breeding values (EBV) of sires having daughters in production eructing the highest and the lowest methane content was 21.80, 22.75 and 24.89 kg per lactation for the first three parities. Positive genetic correlations were estimated between indicator traits and milk fat and protein content. Low negative correlation was observed with milk yield. In conclusion, this study shows the feasibility to predict methane indicator traits by MIR. Moreover, the estimated genetic parameters suggest also a potential genetic variability of the quantity of methane eructed by dairy cows. [less ▲]

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See detailPre-transplant prognostic factors of long-term survival after allogeneic peripheral blood stem cell transplantation with matched related/unrelated donors
SERVAIS, Sophie ULg; Porcher, Raphael; Xhaard, Aliénor et al

in Haematologica (in press)

Mobilized peripheral blood has become the predominant stem cell source for allogeneic hematopoietic cell transplantation. Few studies have compared outcome of HLA-matched related and HLA-matched unrelated ... [more ▼]

Mobilized peripheral blood has become the predominant stem cell source for allogeneic hematopoietic cell transplantation. Few studies have compared outcome of HLA-matched related and HLA-matched unrelated donor peripheral blood stem cell transplants. We conducted a retrospectivesingle-center analysis of 442 patients with hematologic malignancies who underwent peripheral blood stem cell transplantationfrom matched related or matched unrelated donorand we analyzed prognostic factors for long-term survival.To account for disease/status heterogeneity, patients were risk-stratified according to theDisease Risk Index.Five-year overall survival was similar aftertransplants with matched related and unrelated donor. Because donor age ≥60 years impacted outcome during model building, we further considered 3 groups of donors: matched unrelated donor (aged < 60 years by definition), matched related donor aged <60 yearsand matched related donoraged ≥60 years. In multivariate analysis, donor type/age groupand graft CD34+ and CD3+ cell doses significantly impactedlong-term survival. Transplants with matched unrelated donor and matched related donor<60years resulted in similar long-term survival while transplant with matched related donor≥60years was associated with higher risks for late mortality and treatment failure. Lower mortality risks were observed after transplant with CD34+ cell dose > 4.5 x 106/kgand CD3+ cell dose > 3 x 108/kg. The Disease Risk Index failed to predictsurvival. We builtan “Adapted Disease Risk Index” by modifying risks for myeloproliferative neoplasms and multiple myeloma, thatimproved stratification ability for progression-free survivalbut not for overall survival. [less ▲]

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See detailOn the pragmatics of subjectification. The emergence and grammaticalization of a verb-less Allative Future in Ancient Egyptian
Grossman, Eitan; Polis, Stéphane ULg

in Acta Linguistica Hafniensia : International Journal of Linguistics (in press)

In this paper, we argue that an expanded conception of the distinction between speaker-oriented and subject-oriented inferences is crucial for understanding the motivations and mechanisms of semantic ... [more ▼]

In this paper, we argue that an expanded conception of the distinction between speaker-oriented and subject-oriented inferences is crucial for understanding the motivations and mechanisms of semantic change in grammaticalization and subjectivation, on the one hand, and for clarifying the links between semantic change and reductive formal changes. Speaker-oriented inferences have significant consequences, leading to the relaxation of selectional restrictions on a construction. In turn, the relaxation of selectional restrictions can create conditions in which the type- and token-frequency of a construction can rise considerably. Furthermore, changes in the selectional restrictions on a construction can themselves catalyze semantic change by coercing listeners into new form-function pairings. This framework is applied to the grammaticalization of allative futures, a typological comparative concept developed in order to compare structurally diverse future tenses. A small typological study allows us to reconsider some problematic pathways of grammaticalization and to suggest some alternative analyses. Following the typological discussion, a detailed diachronic case study of a verbless allative future in Ancient Egyptian is presented. [less ▲]

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See detailEvaluation of the impact of 6-month training by whole body vibration on the risk of falls among nursing home residents, observed over a 12-month period: a single blind, randomized controlled trial.
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Maquet, Didier ULg et al

in Aging clinical and experimental research (in press)

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement ... [more ▼]

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement of motor capacity were observed. OBJECTIVE: The objective of the present study was to evaluate the impact of 6-month training by WBV on functional and motor abilities among nursing home residents observed over a 12-month period. METHODS: Patients were randomized into two groups: the WBV group which received three training sessions every week composed of five series of 15 s of vibration at 30 Hz intensity for a period of 6 months and a control group with normal daily life. The impact of this training on the risk of falls was assessed blindly after 6 and 12 months by the Tinetti Test, the "Timed Up and Go" test and a quantitative evaluation of a 10-s walk performed with a tri-axial accelerometer. The occurrence of falls was also observed. RESULTS: 62 elderly healthy volunteers, (47 women and 15 men, mean age 83.2 +/- 7.9 years) were included in this study. There was no significant difference between the two groups regarding the Tinetti test (p = 0.75), the "Timed Up and Go" test (p = 0.19) and the Locometrix(R) test, except for the step length, measured by dual task (p < 0.01). No significant inter-group difference in the frequency of falls was observed during the 12 months of research. A total of 42 falls were recorded during the first 6 months of experimentation: 24 falls in the treated group and 18 in the control group (p = 0.60). During the next 6 months, 19 falls occurred: 8 falls in the treated group and 11 in the control group (p = 0.52). CONCLUSION: This study failed to establish the effectiveness of low doses of WBV, under the conditions used in our study, on functional and motor abilities of institutionalized elderly patients. However, given the positive results of other studies, further investigations, with modified therapeutic protocols, seem necessary to clarify the effects of WBV in the elderly. [less ▲]

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See detailBrain metabolic dysfunction in Capgras delusion during Alzheimer’s disease: a positron emission tomography study
Jedidi, Haroun ULg; Daury, Noémy; Rémi, Capa et al

in American Journal of Alzheimer's Disease & Other Dementias (in press)

Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since ... [more ▼]

Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer’s disease (AD) and Capgras syndrome was compared with those of 24 healthy elderly subjects and 26 AD patients without delusional syndrome. Compared to the healthy and AD groups, the patient had significant hypometabolism in frontal and posterior midline structures. In light of current neural models of face perception, our patient’s Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex. [less ▲]

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See detailAn overview of nonintrusive characterization, propagation, and sensitivity analysis of uncertainties in computational mechanics
Arnst, Maarten ULg; Ponthot, Jean-Philippe ULg

in International Journal for Uncertainty Quantification (in press)

In this paper, we offer a short overview of a number of methods that have been reported in the computational-mechanics literature for quantifying uncertainties in engineering applications. Within a ... [more ▼]

In this paper, we offer a short overview of a number of methods that have been reported in the computational-mechanics literature for quantifying uncertainties in engineering applications. Within a probabilistic framework, we describe the characterization of uncertainties using mathematical statistics methods, the propagation of uncertainties through computational models using either Monte Carlo sampling or stochastic expansion methods, and the sensitivity analysis of uncertainties using variance- and differentiation-based methods. We restrict our attention to nonintrusive methods that can be implemented as wrappers around existing computer programs, thus requiring no modification of the source code. We include some recent advances in the propagation and sensitivity analysis of uncertainties that are characterized by arbitrary probability distributions that may exhibit statistical dependence. Finally, we demonstrate the methods integrated in the proposed overview through a nonlinear engineering application relevant to metal forming. [less ▲]

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See detailCompte rendu de l'ouvrage de C. E. Barrett, "Egyptianizing Figurines from Delos. A Study in Hellenistic Religion"
Veymiers, Richard ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (in press), 27

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See detailScience et Dynastie en Belgique : les "conseillers scientifiques" du Roi sous Albert Ier et Léopold III
Pirot, Pascal ULg

in Mosaïque, revue de jeunes chercheurs en SHS – Lille Nord de France – Belgique (in press)

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See detailA Text Structure Indicator and two Topological Methods: New Ways for Studying Latin Historic Narratives
Longrée, Dominique ULg; Mellet, Sylvie

in International Journal of Corpus Linguistics (in press)

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See detailA review of inversion techniques related to the use of relationship matrices in animal breeding
Faux, Pierre ULg; Gengler, Nicolas ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

In animal breeding, prediction of genetic effects is usually obtained through the use of mixed models. For any of these genetic effects, mixed models require the inversion of the covariance matrix ... [more ▼]

In animal breeding, prediction of genetic effects is usually obtained through the use of mixed models. For any of these genetic effects, mixed models require the inversion of the covariance matrix associated to that effect, which is equal to the associated relationship matrix times the associated component of the genetic variance. Given the size of many genetic evaluation systems, computing the inverses of these relationship matrices is not trivial. In this review, we aim to cover computational techniques that ease inversion of relationship matrices used in animal breeding for prediction of the following different types of genetic effects: additive effect, gametic effect, effect due to presence of marked quantitative trait loci, dominance effect and different epistasis effects. Construction rules and inversion algorithms are detailed for each relationship matrix. In the final discussion, we draw up a common theoretical frame to most of the reviewed techniques. Two computational constraints come out of this theoretical frame: setting up the matrix of dependencies between levels of the effect and setting up some parts (diagonal or block-diagonal elements) of the relationship matrix to be inverted. [less ▲]

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See detailA New Shift-Share Method
Artige, Lionel ULg; Van Neuss, Leif ULg

in Growth and Change (in press)

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant ... [more ▼]

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant variable) relative to the national average. This technique has always been subject to criticism for its lack of theoretical basis. This paper presents a critical assessment of the methods suggested by Dunn (1960) and by Esteban-Marquillas (1972) and proposes a new shift-share method, which separates out the two effects unambiguously. By way of illustration, we provide an application to manufacturing employment in the Belgian provinces between 1995 and 2007. [less ▲]

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See detailClinical pattern characterisation of cattle naturally infected by BTV-8 - Clinical characterisation of BTV-8 infected cattle
Zanella, G; Martinelle, Ludovic ULg; Guyot, Hugues ULg et al

in Transboundary and Emerging Diseases (in press)

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See detailA Double-Blind, Placebo Controlled, Randomized Trial to Assess the Impact of a Monthly Administration of 50,000 IU of Vitamin D3 for 6 Months on Serum Levels of 25-Hydroxyvitamin D in Healthy Young Adults
Brunel, Elodie ULg; SCHNITZLER, Maryline ULg; Foidart-Dessalle, Marguerite ULg et al

in International Journal of Endocrinology (in press)

In this double blind, unicentre, randomized, placebo controlled study, we evaluated the changes in 25-hydroxyvitamin D (25(OH)D) serum levels in 150 young Belgian adults (18–30 years), monthly ... [more ▼]

In this double blind, unicentre, randomized, placebo controlled study, we evaluated the changes in 25-hydroxyvitamin D (25(OH)D) serum levels in 150 young Belgian adults (18–30 years), monthly supplemented with 50,000 IU of vitamin D (VTD) or placebo for 6 months, from November 2010 to May 2011. At T0, 30% of the population presented 25(OH)D serum levels below 20 ng/mL. In the VTD-treated group, mean serum levels increased from 21.2 ± 8.2 to 30.6 ± 8.8 ng/mL (𝑃 < 0.001) at T3mo and to 36.0 ± 9.2 ng/mL (𝑃 < 0.001) at T6mo. Despite documented VTD intake, no changes in serum levels were, however, observed in 10% of the treated group. In the placebo group, mean 25(OH)D serum levels decreased from22.8 ± 8.5 to 14.0 ± 6.9 ng/mL at T3mo (𝑃 < 0.001) but returned to values not significantly different from those observed at T0 (23.5 ± 8.6 ng/mL) at T6mo. No difference between serum calcium levels was observed between the groups throughout the study. In conclusion, monthly supplementation with50,000UIofVTDinwinter canwarrant serum25(OH)Dlevels above 20ng/mL in96.2%of thosehealthy young adultswithout inducing unacceptably high 25(OH)D concentration. This supplementation is safe andmay be proposed without 25(OH)D testing. [less ▲]

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See detailMonitoring of osteoporosis therapy
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Best Practice & Research. Clinical Endocrinology & Metabolism (in press)

Over the past two decades, major advances have been made in the number and range of agents available for the treatment of osteoporosis, all with proven anti-fracture efficacy. Unfortunately, compliance ... [more ▼]

Over the past two decades, major advances have been made in the number and range of agents available for the treatment of osteoporosis, all with proven anti-fracture efficacy. Unfortunately, compliance with these treatments is not optimal, and a number of patients could be considered as non-responders. Consequently, monitoring anti-osteoporotic therapy could be part of successful osteoporosis management. Currently, no formal well-accepted clinical practice guidelines are available for monitoring anti-osteoporosis therapies. Changes in bone mineral density and bone turnover markers, while on therapy, have potential value in monitoring treatment but their assessment and, consequently, their benefits could be limited by metrological and clinical issues. Moreover, their effectiveness is probably drug dependant. Recommendation for the standardisation of the methodology when analysing the potential relevance of tools for the monitoring of osteoporosis therapy is needed. [less ▲]

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See detailAlgebrability and nowhere Gevrey differentiability
Bastin, Françoise ULg; J. Alberto, Conejero; Esser, Céline ULg et al

in Israel Journal of Mathematics (in press)

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and ... [more ▼]

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and, therefore, lineability) of functions enjoying this property. In the process of proving these results we also provide a new construction of nowhere Gevrey di fferentiable functions. [less ▲]

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See detailLe rôle de la perception de soi comme lecteur dans le développement de la compétence en lecture
Schillings, Patricia ULg; Dupont, Virginie; Neuberg, France ULg et al

in Mesure et Evaluation en Education [=MEE] (in press)

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See detailProteins in the gas phase
Meyer, Tim; Gabelica, Valérie ULg; Grubmüller, Helmut et al

in Wiley Interdisciplinary Reviews: Computational Molecular Science (in press)

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins ... [more ▼]

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins have thus been carried out in aqueous environment. However, recent experimental approaches have opened the possibility to gain structural information on proteins from gas-phase measurements. The obtained results revealed significant structural memory in proteins when transferred from water to the gas phase. However, after several years of experimental and theoretical research, the nature of the structural changes induced by vaporization, the exact characteristics of proteins in the gas phase, and the physicochemical forces stabilizing dehydrated proteins are still unclear. We will review here these issues using both experimental and theoretical sources of information. [less ▲]

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See detailSoil contamination near a former Zn-Pb ore-treatment plant: Evaluation of deterministic factors and spatial structures at the landscape scale
Liénard, Amandine ULg; Brostaux, Yves ULg; Colinet, Gilles ULg

in Journal of Geochemical Exploration (in press)

Historical soil contamination within a 3 km radius of a former ore treatment plant was evaluated. A total of 247 topsoil samples were collected in a stratified random sampling design taking into account ... [more ▼]

Historical soil contamination within a 3 km radius of a former ore treatment plant was evaluated. A total of 247 topsoil samples were collected in a stratified random sampling design taking into account three factors: land use (LU), soil type (ST) and wind direction (WD). Concentrations of trace elements (Cd, Co, Cr, Cu, Ni, Pb and Zn) and major elements (Ca, Mg, K, Fe, Al, Mn) as well as various soil properties (pHwater, pHKCl, TOC and N) were measured. Total Cd, Pb and Zn concentrations were higher than typical background values. Enrichment factors for these three metals were, respectively, 260, 77.4 and 35.5. Principal components analysis (PCA) and factor analysis segregated anthropogenic contamination as a premier factor in influencing concentrations, followed by a second lithogenic factor. The anthropogenic origin of substantial contamination was confirmed though mapping of sample locations relative to contaminant sources. Factor 1 (26.5% of the variance) impacts a large area around the contaminated site and is also indicative of WD influence. Factor 2 (23.9% of the variance) is naturally linked to the local lithology and geology. LU and soil fertility are, respectively, represented by factor 3 (16.5% of the variance), which is linked to pH, and factor 4 (9.3% of the variance), related to organic content. The significance of landscape factors in the spatial distribution of metallic trace elements (MTE) was assessed with an ANCOVA using “distance to the source” as a covariate. Results of the analysis support the hypothesis that Cd, Cu, Pb and Zn concentrations are mainly driven by anthropogenic factors, specifically historical industrial activity at the former ore treatment plant. The ANCOVA also provides a means to quantify the impact of LU and ST as well, particularly on MTE availability in soils. The presence of MTE in soil poses known, and potentially significant, risks to both human health and the environment. [less ▲]

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See detailAn algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Bruyère, Olivier ULg; Cooper, C; Pelletier, JP et al

in Seminars in Arthritis & Rheumatism (in press)

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to ... [more ▼]

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to develop a treatment algorithm recommendation that is easier to interpret for the prescribing physician based on the available evidence and that is applicable in Europe and internationally. The knee was used as the model OA joint. Methods: ESCEO assembled a task force of 13 international experts (rheumatologists, clinical epidemiologists, and clinical scientists). Existing guidelines were reviewed; all interventions listed and recent evidence were retrieved using established databases. A first schematic flow chart with treatment prioritization was discussed in a 1-day meeting and shaped to the treatment algorithm. Fine-tuning occurred by electronic communication and three consultation rounds until consensus. Results: Basic principles consist of the need for a combined pharmacological and non-pharmacological treatment with a core set of initial measures, including information access/education, weight loss if overweight, and an appropriate exercise program. Four multimodal steps are then established. Step 1 consists of background therapy, either non-pharmacological (referral to a physical therapist for re-alignment treatment if needed and sequential introduction of further physical interventions initially and at any time thereafter) or pharmacological. The latter consists of chronic Symptomatic Slow-Acting Drugs for OA (e.g., prescription glucosamine sulfate and/or chondroitin sulfate) with paracetamol at-need; topical NSAIDs are added in the still symptomatic patient. Step 2 consists of the advanced pharmacological management in the persistent symptomatic patient and is centered on the use of oral COX-2 selective or non-selective NSAIDs, chosen based on concomitant risk factors, with intra-articular corticosteroids or hyaluronate for further symptom relief if insufficient. In Step 3, the last pharmacological attempts before surgery are represented by weak opioids and other central analgesics. Finally, Step 4 consists of end-stage disease management and surgery, with classical opioids as a difficult-to-manage alternative when surgery is contraindicated. Conclusions: The proposed treatment algorithm may represent a new framework for the development of future guidelines for the management of OA, more easily accessible to physicians. © 2014 The Authors. [less ▲]

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See detailCOMMENT JE TRAITE ... L’arrêt cardio-respiratoire extrahospitalier : la fenêtre du centraliste 112
STIPULANTE, Samuel ULg; ZANDONA, Régine; EL-FASSI, Mehdi ULg et al

in Revue Médicale de Liège (in press), 69

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See detailNon-isothermal moisture balance equation in porous media: a review of mathematical formulations in Building Physics
Dubois, Samuel ULg; Lebeau, Frédéric ULg; Evrard, Arnaud ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Understanding heat and mass transfers in porous materials is crucial in many areas of scientific research. Mathematical models have constantly evolved, their differences lying mainly in the choice of the ... [more ▼]

Understanding heat and mass transfers in porous materials is crucial in many areas of scientific research. Mathematical models have constantly evolved, their differences lying mainly in the choice of the driving potentials used to describe moisture flows, as well as in the complexity of characterizing the physical phenomena involved. Models developed in the field of Building Physics (HAM models) are used to describe the behavior of envelope parts and assess their impact on user comfort and energy performance. The water balance equation can be described in many ways; it is a function of the boundary conditions considered and the fact they induce high or low water content in the porous materials used. This paper gives an overview of various formulations for this equation that are found in the Building Physics literature. It focuses first on the physically based formulation of moisture balance, drawing on the Representative Elementary Volume (REV) concept, coupled with thermodynamic flow rates description. This is then reformulated in line with various main moisture state variables offering a wide variety of expressions that are compared with available models. This approach provides access to all secondary transport coefficients associated with the process of mathematical transformation. Particular emphasis is placed on the moisture storage function choice and its impact on the final mathematical formulations. [less ▲]

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See detailRationale for the potential use of mesenchymal stromal cells in liver transplantation
Vandermeulen, M.; DE ROOVER, Arnaud ULg; BRIQUET, Alexandra ULg et al

in World Journal of Gastroenterology (in press)

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See detailCan the collapse of a fly ash heap develop into an air-fluidized flow? - Reanalysis of the Jupille accident (1961)
Stilmant, Frédéric ULg; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Geomorphology (in press)

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of ... [more ▼]

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of fluidization attracted scientific attention. As drillings and direct observations revealed no water-saturated zone at the base of the deposits, scientists assumed an air-fluidization mechanism, which appeared consistent with the properties of the material. In this paper, the air-fluidization assumption is tested based on two-dimensional numerical simulations. The numerical model has been developed so as to focus on the most prominent processes governing the flow, with parameters constrained by their physical interpretation. Results are compared to accurate field observations and are presented for different stages in the model enhancement, so as to provide a base for a discussion of the relative influence of pore pressure dissipation and pore pressure generation. These results show that the apparently high diffusion coefficient that characterizes the dissipation of air pore pressures is in fact sufficiently low for an important degree of fluidization to be maintained during a flow of hundreds of meters. [less ▲]

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See detailLa maladie de Lyme entre cadrage infectieux, vectoriel et zoonotique : vers une écologisation des problèmes sanitaires ?
Massart, Clémence ULg

in VertigO : la Revue Electronique en Sciences de l'Environnement (in press)

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ... [more ▼]

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ricinus en Europe ; Ixodes persulcatus en Asie ; Ixodes scapularis aux États-Unis et au Canada). Les médecins et les malades ont d’abord développé un cadrage infectieux, ancré dans la santé humaine, réservé à Lyme et soumis à une vive controverse. Progressivement, un second cadrage vectoriel s’est structuré autour des entomologistes médicaux puis des écologues, généralement étrangers à la problématique des maladies humaines. Axé sur le vecteur, ce cadrage englobe les autres maladies transmises par Ixodes ricinus en Europe qui, durant les 30 dernières années, n’ont cessé d’être découvertes : bartonnelles, babésioses, tularémie, encéphalite à tiques, etc. Combinée à ces nouvelles pathologies, la notoriété de Lyme a finalement contribué à ouvrir la catégorie « transmission vectorielle » – traditionnellement associée aux moustiques des pays tropicaux – aux tiques et aux maladies de l’hémisphère nord qu’elles véhiculent. Un troisième cadrage axé sur les réservoirs et qualifié de zoonotique commence enfin à se dessiner. Il faut reconnaître dans cette juxtaposition des cadrages – infectieux, vectoriel et zoonotique – une forme d’écologisation des problèmes sanitaires. [less ▲]

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See detailCompte-rendu de l'ouvrage de Pierre RICHÉ, Être enfant au Moyen Âge
Close, Florence ULg

in Moyen Age (Le) (in press)

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See detailDynamiques transactionnelles de reconnaissance et professionnalisation des stagiaires : perspectives pour la formation initiale
Dejean, Karine ULg

in Education et Formation (in press)

Cet article prend appui sur une recherche doctorale. A partir de l’analyse de récits d’expériences marquantes, à forte charge émotionnelle, rapportées par des enseignants débutants, des schémas ... [more ▼]

Cet article prend appui sur une recherche doctorale. A partir de l’analyse de récits d’expériences marquantes, à forte charge émotionnelle, rapportées par des enseignants débutants, des schémas d’intelligibilité de ces situations vécues ont été construits. Ceux-ci rendent compte des transformations identitaires et émotionnelles des enseignants débutants au travers des dynamiques transactionnelles de reconnaissance. Ces résultats ouvrent des perspectives pour la formation initiale des enseignants et l’accompagnement des enseignants débutants. Les schémas d’intelligibilité pourront être utilisés dans une démarche de réflexivité pour faciliter le décodage de situations professionnelles à forte charge émotionnelle vécues par l’enseignant et l’aider à donner sens à ses expériences [less ▲]

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See detail“How are you Vulnerable?”: Using Participation for Vulnerability Analysis in Emergency Planning
Rossignol, Nicolas ULg; Turcanu, Catrinel; Fallon, Catherine ULg et al

in Journal of Risk Research (in press)

Scientists in many fields of research have developed models, theories and concepts attempting to grasp and manage dangers that are often difficult to imagine. Among the different perspectives, the Science ... [more ▼]

Scientists in many fields of research have developed models, theories and concepts attempting to grasp and manage dangers that are often difficult to imagine. Among the different perspectives, the Science and Technology Studies (STS) Vulnerability Approach seems very promising. Relying on a constructivist paradigm, it is based on an inductive collection and analysis of a wide range of factors, with a particular focus on cultural factors and actual day-to-day practices. In this paper, we present the roots of this approach and we display findings based on three case studies exploring emergency planning in three different contexts (a city near a SEVESO plant, a school near a nuclear plant, and a city confronted to multiple catastrophic scenarios). The cases studies were realized by conducting three Focus Groups with different types of stakeholders (citizens, teachers, firemen, decision makers, etc.). After presenting the results of the case studies, we discuss how stakeholders’ participation can inform such type of vulnerability analysis in the context of emergency planning. We argue that participation fosters a deep understanding of actual safety governance practices which allows innovative results to emerge as well as it initiates a learning process among the participants. It contributes to questioning the relations between decision-makers, experts and citizens. It has the potential of bypassing the positivist and quantitative rationale of safety, and thus, of redefining the vulnerability governance. As a conclusion, we question the role of such STS vulnerability approach within the actual vulnerability governance. [less ▲]

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See detailDevonian antiarch placoderms from Belgium revisited
Olive, Sébastien ULg

in Acta Palaeontologica Polonica (in press)

Anatomical, systematic, and paleobiogeographical data on the Devonian antiarchs from Belgium are reviewed, updated and completed thanks to new data from the field and re-examination of paleontological ... [more ▼]

Anatomical, systematic, and paleobiogeographical data on the Devonian antiarchs from Belgium are reviewed, updated and completed thanks to new data from the field and re-examination of paleontological collections. The material of Bothriolepis lohesti Leriche, 1931 is enhanced and the species better described. An undetermined species of Bothriolepis is recorded from the Famennian of Modave (Liège Province), one species of Asterolepis redescribed from the Givetian of Hingeon and another one described from the Givetian of Mazy (Namur Province). Grossilepis rikiki sp. nov. is recorded from the Famennian tetrapod-bearing locality of Strud (Namur Province) and from the Famennian of Moresnet (Liège Province). It is the first occurrence of Grossilepis after the Frasnian and on the central southern coast of the Euramerican continent. Its occurrence in the Famennian of Belgium may be the result of a late arrival from the Moscow Platform and the Baltic Depression, where the genus is known from Frasnian deposits. Remigolepis durnalense sp. nov. is described from the Famennian of Spontin near Durnal (Namur Province). Except for the doubtful occurrence of Remigolepis sp. in Scotland, this is the first record of this genus in Western Europe. Its occurrence in Belgium reinforces the strong faunal affinities between Belgium and East Greenland and the hypothesis of a hydrographical link between the two areas during the Late Devonian. [less ▲]

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See detailCompte-rendu de l'ouvrage de Boyd Taylor COOLMAN et Dale M. COULTER : Trinity and creation
Close, Florence ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailEffets d’amendements carbonatés et organiques sur la culture de deux légumes sur sol contaminé à Lubumbashi (RD Congo)
Mpundu Mubemba, Michel; Useni, Yannick; Nyembo, Lucien et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Given the risks of contamination of the vegetables grown in gardens in the city of Lubumbashi due to soil pollution, agronomic solutions to reduce these risks have been experimented. The choice of ... [more ▼]

Given the risks of contamination of the vegetables grown in gardens in the city of Lubumbashi due to soil pollution, agronomic solutions to reduce these risks have been experimented. The choice of appropriate amendments (type and quantity) and the selection of plant varieties able to restrict transfers of trace metals (TM) from the soil to plant edible organs are part of the most conventional remediation techniques. Amaranth and spinach beet have been cultivated in pot trials according to randomized complete blocks with four replications on a contaminated soil that received different doses of liming and/or organic products and slightly contaminated soil. Along with an effect on soil chemistry, the amendments have been effective in reducing the transfer of trace metals from soil to plant. The lime-based treatments were more effective than compost. TM levels in plants however remained high whatever the application of amendments and the question of food chain contamination remains posed. [less ▲]

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See detailA European patient record study on diagnosis and treatment of chemotherapy-induced anaemia
Ludwig, H.; Aapro, M.; Bokemeyer, C. et al

in Supportive Care in Cancer (in press)

Purpose – Patients with cancer frequently experience chemotherapy‐induced anaemia (CIA) and iron deficiency (ID). Erythropoiesis‐stimulating agents (ESA), iron supplementation and blood transfusions are ... [more ▼]

Purpose – Patients with cancer frequently experience chemotherapy‐induced anaemia (CIA) and iron deficiency (ID). Erythropoiesis‐stimulating agents (ESA), iron supplementation and blood transfusions are available therapies. This study evaluated routine practice in CIA management. Methods – Medical oncologists and/or haematologists from nine European countries (n=375) were surveyed on their last five cancer patients treated for CIA (n=1730). Information was collected on tests performed at diagnosis of anaemia, levels of haemoglobin (Hb), serum ferritin and transferrin saturation (TSAT), and applied anaemia therapies. Results – Diagnostic tests and therapies for CIA varied across Europe. Anaemia and iron status were mainly assessed by Hb (94%) and ferritin (48%) measurements. TSAT was only tested in 14%. At anaemia diagnosis, 74% of patients had Hb ≤10g/dL, including 15% with severe (Hb <8g/dL) anaemia. Low iron levels (ferritin ≤100ng/mL) were detected in 42% of evaluated patients. ESA was the most commonly used treatment (63%) and 30% of ESA‐treated patients also received iron supplementation. Most iron‐treated patients (74%) received an oral iron; intravenous iron was administered to 26%. 52% of patients received transfusions and in 76% of these, transfusions formed part of a regular anaemia treatment regimen. Management practices were similar in 2009 and 2011. Conclusion – Management of anaemia and iron status in patients treated for CIA varies substantially across Europe. Iron status is only assessed in half of the patients. In contrast to clinical evidence, iron treatment is underutilised and mainly based on oral iron supplementation. Implementation of guidelines needs to be increased, particularly the minimisation of blood transfusions. [less ▲]

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See detailÉtude des contraintes mécaniques locomotrices chez le cheval
Noble, Prisca ULg; Collin, Bernard ULg; Denoix, Jean-Marie et al

in Annales de Médecine Vétérinaire (in press)

In locomotor biomechanics, three high groups of contraints are commonly encountared : pressure, traction and torsion. In supra-maximal conditions, all of these contraints would be responsible of some ... [more ▼]

In locomotor biomechanics, three high groups of contraints are commonly encountared : pressure, traction and torsion. In supra-maximal conditions, all of these contraints would be responsible of some equine diseased locomotor systems. In order to understand better the contraints in the equine locomotor dynamics, some investigations have been carried out. Moreover, some measurement methods, based on the mechanics of Newton, have been performed. This review shows the different measurement techniques and introduces the mechanical basis that are compulsory for the understanding of the equine locomotor apparatus functioning. [less ▲]

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See detailDevelopment of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach
Silva, Joana M.; Vandermeulen, Gaëlle; Oliveira, Vanessa G. et al

in Nanomedicine (in press)

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based ... [more ▼]

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based nanoparticles and mannose-grafted nanoparticles were formulated and physicochemically characterized. Immortalized and primary antigen-presenting cells were used to study nanoparticle internalization patterns. The endocytic pathways and intracellular trafficking followed by nanoparticles were also investigated. Results & discussion: Nanoparticles displayed mannose residues available for binding at the nanoparticle surface. Different nanoparticle internalization patterns by immortalized and primary antigen presenting cells were verified. Macropinocytosis, clathrin-mediated endocytosis, caveolin- and lipid raft-dependent endocytosis are involved in nanoparticles internalization. Nanoparticles demonstrate both endo-lysosomal and cytosolic localizations and a tendency to accumulate nearby the endoplasmic reticulum. Conclusion & future perspective: The developed nanoparticles might drive antigens to be presented through MHC class I and II molecules to both CD8+ and CD4+ T cells, favoring a complete and coordinated immune response. [less ▲]

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See detailEffet du mode de conservation d’huile de Jatropha curcas L. sur son efficacité dans la lutte contre les principaux insectes ravageurs du niébé (Vigna unguiculata (L.) Walp. au Niger
Abdoul Habou, zakari; Toudou, Adam; Haubruge, Eric ULg et al

in Tropicultura (in press)

Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to ... [more ▼]

Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to light and the other kept in the dark. The insecticidal efficacy was evaluated in a field with three concentrations (5, 10 and 15%) trial on the main pests of Cowpea (Vigna unguiculata (L.) Walp) and in a laboratory test on Megalurothrips sjostedti Trybon (Thysanoptera: Thripidae) with different concentrations of crude oil (50; 100; 150 and 200 µl). No difference in insecticidal effect was found between the two modes of oil conservation, both in the laboratory and in the field. In the field, regardless of the mode of conservation, the concentrations of 10% of J. curcas oil enables a reduction of over than 80% of thrips, aphids, and bugs compared to the control. Its increased seeds yield more than 50%. The concentration of 15% gives an insecticidal effect comparable to that of the reference treatment (deltaméthrine) but induces phytotoxicity symptoms on the leaves of Cowpea. [less ▲]

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See detailControllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping
Peterchev, Angel; D'Ostilio, Kevin ULg; Rothwell, John et al

in Journal of Neural Engineering (in press)

Abstract. Objective. This work aims at flexible and practical pulse parameter control in transcranial magnetic stimulation (TMS), which is currently very limited in commercial devices. Approach. We ... [more ▼]

Abstract. Objective. This work aims at flexible and practical pulse parameter control in transcranial magnetic stimulation (TMS), which is currently very limited in commercial devices. Approach. We present a third generation controllable pulse parameter device (cTMS3) that uses a novel circuit topology with two energy-storage capacitors. It incorporates several implementation and functionality advantages over conventional TMS devices and other devices with advanced pulse shape control. cTMS3 generates lower internal voltage differences and is implemented with transistors with lower voltage rating than prior cTMS devices. Main results. cTMS3 provides more flexible pulse shaping since the circuit topology allows four coil-voltage levels during a pulse, including approximately zero voltage. The nearzero coil voltage enables snubbing of the ringing at the end of the pulse without the need for a separate active snubber circuit. cTMS3 can generate powerful rapid pulse sequences (< 10 ms inter pulse interval) by increasing the width of each subsequent pulse and utilizing the large capacitor energy storage, allowing the implementation of paradigms such as paired-pulse and quadripulse TMS with a single pulse generation circuit. cTMS3 can also generate theta (50 Hz) burst stimulation with predominantly unidirectional electric field pulses. The cTMS3 device functionality and output strength are illustrated with electrical output measurements as well as a study of the effect of pulse width and polarity on the active motor threshold in 10 healthy volunteers. Significance. The cTMS3 features could extend the utility of TMS as a research, diagnostic, and therapeutic tool. [less ▲]

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See detailChild labour, Agency and Family dynamics: The Case of Mining in Katanga (DRC)
Andre, Géraldine ULg; Godin, Marie

in Childhood (in press)

In the last three decades, the development of the artisanal and small-scale mining (ASM) sector has been increasing in the Democratic Republic of Congo (DRC), bringing more and more urban families into ... [more ▼]

In the last three decades, the development of the artisanal and small-scale mining (ASM) sector has been increasing in the Democratic Republic of Congo (DRC), bringing more and more urban families into this flourishing business sector, and among them, children. At first glance, one could see children in the mining sector mainly as victims entangled in the flows of raw materials of unbridled capitalism. But this paper aims to look at the often unconceivable, and as a result neglected, social agency of children even when they are involved in stigmatized and prohibited types of child labour. To do so, it relies on the results of a socio-anthropological collective research project on children’s mining activities which was carried out in a small locality called La Ruashi in the city of Lubumbashi (Province of Katanga). The article aims to provide a more comprehensive understanding of what is often normatively only labelled as ‘child labour’ by looking at different spheres of social relations within which children are embedded. Examining the set of social interactions that children have with their families, the broader community and their ‘peers’, several ‘family portraits’ are offered, highlighting a heterogeneity of social interpretations regarding this ‘new’ form of child work. It will be shown that for families from middle-class background, this kind of work is often socially disruptive, at the forefront of inter-generational conflict. As for families from lower classes, social changes induced by children’s mining activities are often better incorporated into the family habitus. Common social changes encountered in all families irrespective of class belonging will also be portrayed, showing the transversal societal impact these ‘new’ forms of child economic activities can provoke at a micro level. [less ▲]

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See detailDes intentions aux actes : la volition en conseil d'orientation
Broonen, Jean-Paul ULg

in L'Orientation Scolaire et Professionnelle (in press)

A model limited to motivation construct to explain the way from setting a vocational goal to its achievement cannot claim to give an account of how to overcome regulatory problems during goal striving. A ... [more ▼]

A model limited to motivation construct to explain the way from setting a vocational goal to its achievement cannot claim to give an account of how to overcome regulatory problems during goal striving. A model linking volition to motivation is needed. In particular, implementation intentions have been proved to be effective in helping the initiation of goal striving, shielding goal pursuit from unwelcome influences, and disengagement from not successful courses of action. It is proposed to extend the application of this volitional cognitive tool to career counselling. [less ▲]

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See detailInvestigating word recognition in intercomprehension: methods and findings
Möller, Robert ULg; Zeevaert, Ludger ULg

in Linguistics (in press), 53(2),

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See detailInput of supercritical carbon dioxide to polymer synthesis: an overview
Boyère, Cédric; Jérôme, Christine ULg; Debuigne, Antoine ULg

in European Polymer Journal (in press)

The ongoing search for environmentally friendlier alternative to the organic solvents used in chemical processes has led to the development of technologies based on supercritical carbon dioxide (scCO2 ... [more ▼]

The ongoing search for environmentally friendlier alternative to the organic solvents used in chemical processes has led to the development of technologies based on supercritical carbon dioxide (scCO2), which is non-flammable, non-toxic and relatively inert fluid. Polymer chemistry does not escape this trend and last achievements in the field of polymer synthesis in scCO2 are reviewed here. Without claiming to be exhaustive, we go through and discuss the benefits of the main polymerization processes in scCO2 including homogeneous, precipitation, dispersion, suspension and emulsion systems. A particular attention is drawn to water/carbon dioxide emulsion polymerization and to the suited surface active agents. This review also underlines that heterogeneous polymerization based on CO2 is more than a strategy for reducing the ecological footprint of the polymer production but it allows structuring the polymer materials into particles or highly interconnected macroporous networks. [less ▲]

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See detailInfluence of Homogenization Treatment on Physicochemical 4 Properties and Enzymatic Hydrolysis Rate of Pure 5 Cellulose Fibers
Jacquet, Nicolas ULg; Vanderghem, Caroline ULg; Danthine, Sabine ULg et al

in Applied Biochemistry and Biotechnology (in press)

The aim of this study is to compare the effect of different homogenization treat- 12 ments on the physicochemical properties and the hydrolysis rate of a pure bleached 13 cellulose. Results obtained show ... [more ▼]

The aim of this study is to compare the effect of different homogenization treat- 12 ments on the physicochemical properties and the hydrolysis rate of a pure bleached 13 cellulose. Results obtained show that homogenization treatments improve the enzymatic 14 hydrolysis rate of the cellulose fibers by 25 to 100 %, depending of the homogenization 15 treatment applied. Characterization of the samples showed also that homogenization had an 16 impact on some physicochemical properties of the cellulose. For moderate treatment inten- 17 sities (pressure below 500 b and degree of homogenization below 25), an increase of water 18 retention values (WRV) that correlated to the increase of the hydrolysis rate was highlighted. 19 Result also showed that the overall crystallinity of the cellulose properties appeared not to be 20 impacted by the homogenization treatment. For higher treatment intensities, homogenized 21 cellulose samples developed a stable tridimentional network that contributes to decrease 22 cellulase mobility and slowdown the hydrolysis process. [less ▲]

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See detailSinging ability is rooted in vocal-motor control of pitch
Hutchins, Sean; Larrouy, Pauline ULg; Peretz, Isabelle

in Attention, Perception & Psychophysics (in press)

The inability to vocally match a pitch can be caused by poor pitch perception or by poor vocal-motor control. Although previous studies have tried to examine the relationship between pitch perception and ... [more ▼]

The inability to vocally match a pitch can be caused by poor pitch perception or by poor vocal-motor control. Although previous studies have tried to examine the relationship between pitch perception and vocal production, they have failed to control for the timbre of the target to be matched. In the present study, we compare pitch matching accuracy with an unfamiliar instrument (the slider) and with the voice, designed such that the slider plays back recordings of the participant’s own voice. We also measured pitch accuracy in singing a familiar melody (“Happy Birthday”) to assess the relationship between single pitch matching tasks and melodic singing. Our results showed that participants (all nonmusicians) were significantly better at matching recordings of their own voices with the slider than with their voice, indicating that vocal-motor control is an important limiting factor on singing ability. We also found significant correlations between the ability to sing a melody in tune and vocal pitch matching, but not instrumental pitch matching. Better melodic singers also tended to have higher quality voices (as measured by acoustic variables). These results provide important evidence about the ultimate causes of poor singing ability, and demonstrate that single pitch matching tasks can be useful in measuring general singing abilities. [less ▲]

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See detailJatropha curcas L. (Euphorbiaceae): Insectes ravageurs et propriétés biocides
Abdoul Habou, Zakari; Toudou, Adam; Haubruge, Eric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Jatropha curcas, ou Pourghère, est un arbuste de la famille des Euphorbiacées, largement répandu dans les pays tropicaux. Ses graines sont riches d'une huile pouvant servir de biocarburant dans les ... [more ▼]

Jatropha curcas, ou Pourghère, est un arbuste de la famille des Euphorbiacées, largement répandu dans les pays tropicaux. Ses graines sont riches d'une huile pouvant servir de biocarburant dans les moteurs diesels modifiés. La plante est attaquée par divers insectes ravageurs appartenant principalement aux ordres des Hétéroptères, Coléoptères et Orthoptères. Ils provoquent des dégâts sur les fruits, les inflorescences et les feuilles. Les ravageurs les plus fréquemment observés sur J. curcas sont des punaises du genre Pachycoris (Hétéroptère : Scutelleridae), qui sont largement répandues au Mexique, en Australie, aux États-Unis, au Brésil et au Nicaragua. Ces punaises causent des dégâts importants sur les fruits et provoquent la malformation des graines, et avec elle une réduction de la teneur en huile. Même si les arbustes de Jatropha sont victime d'infestations d'insectes, plusieurs études démontrent l'effet insecticide de son huile contre des ravageurs importants tels que Busseola fusca (Fuller) (Lépidoptère : Noctuidae), Sesamia calamistis Hampson (Lépidoptère : Noctuidae), Aphis gossypii Glover (Homoptère: Aphididae) et Callosobruchus chinensis L. (Coléoptère : Bruchidae). Dans ce document, nous présentons dans une première partie les principaux insectes ravageurs de J. curcas et dans une seconde section les effets insecticides démontrés de son huile. [less ▲]

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See detailThe Sceptical President: Václav Klaus' Influence on Czech Public Opinion on Climate Change
De Pryck, Kari; Gemenne, François ULg

in Climatic Change (in press)

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See detailPreliminary survey on the impact of Schmallenberg virus on sheep flocks in south of Belgium
Saegerman, Claude ULg; Martinelle, Ludovic ULg; Dal Pozzo, Fabiana ULg et al

in Transboundary and Emerging Diseases (in press)

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See detailDominant amphipods of Posidonia oceanica seagrass meadows display considerable trophic diversity
Michel, Loïc ULg; Dauby, Patrick ULg; Gobert, Sylvie ULg et al

in Marine Ecology (in press)

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica ... [more ▼]

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica seagrass meadows and to highlight trophic diversity among this community. Our results indicate that, although all dominant species heavily relied on macroalgal epiphytes, considerable interspecific dietary differences existed. Carbon stable isotope ratios notably showed that some of the amphipod species favored grazing on epiphytes from leaves or litter fragments (Apherusa chiereghinii, Aora spinicornis, Gammarus aequicauda), while others like Dexamine spiniventris preferred epiphytes from rhizomes. The remaining amphipods (Caprella acanthifera, Ampithoe helleri and Gammarella fucicola) readily consumed both groups. In addition, SIAR modeling suggested that most species had a mixed diet, and relied on several food items. Fatty acid analysis and gut contents revealed that contribution of microepiphytic diatoms and of benthic and suspended particulate organic matter to the diet of amphipods were anecdotal. None of the examined species seemed to graze on their seagrass host (low 18:2(n-6) and 18:3(n-3) fatty acids contents), but G. aequicauda partly relied on seagrass leaf detritus, as demonstrated by the lesser 13C-depletion of their tissues. Overall, our findings suggest that amphipods, because of their importance in transfers of organic matter from primary producers and detritus to higher rank consumers, are key-items in P. oceanica associated food webs. [less ▲]

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See detailErythropoietin therapy after allogeneic hematopoietic cell transplantation : a prospective randomized trial
JASPERS, Aurélie ULg; Baron, Frédéric ULg; WILLEMS, Evelyne ULg et al

in Blood (in press)

We conducted a prospective randomized trial to assess hemoglobin (Hb) response to recombinant human erythropoietin (rhEPO) therapy after hematopoietic cell transplantation (HCT). Patients (n=131) were ... [more ▼]

We conducted a prospective randomized trial to assess hemoglobin (Hb) response to recombinant human erythropoietin (rhEPO) therapy after hematopoietic cell transplantation (HCT). Patients (n=131) were randomized (1:1) between no treatment (control arm) or erythropoietin (Neorecormon®) at 500 U/kg/week (EPO arm). Patients were also stratified in 3 cohorts: patients undergoing myeloablative HCT with rhEPO to start on day 28, patients given nonmyeloablative HCT (NMHCT) with rhEPO to start on day 28, and patients also given NMHCT but with rhEPO to start on day 0. The proportion of complete correctors (i.e. achieving Hb ≥ 13 g/dL) before day 126 post-transplant (primary endpoint) was 8.1% in the control arm (median not reached) and 63.1% in the EPO arm (median time 90 days) (p<0.001). Hb levels were higher and transfusions requirements decreased (p<0.001) in the EPO arm, but not during the first month in the nonmyeloablative cohort starting rhEPO on day 0. There was no difference in rates of thrombo-embolic events or other complications between the 2 arms. This is the first randomized trial to demonstrate that rhEPO therapy hastens erythroid recovery and decreases transfusion requirements when started one month after allogeneic HCT. There was no benefit to start rhEPO earlier after NMHCT. [less ▲]

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See detailDabigatran Etexilate and Risk of Myocardial Infarction, Other Cardiovascular Events, Major Bleeding, and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Douxfils, Jonathan; Buckinx, Fanny ULg; Mullier, Francois et al

in Journal of the American Heart Association (in press)

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of ... [more ▼]

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of the published literature and a clinical trials registry maintained by the drug manufacturer. Criteria for inclusion in our meta-analysis included all RCTs and the availability of outcome data for MI, other cardiovascular events, major bleeding, and all-cause mortality. Among the 501 unique references identified, 14 RCTs fulfilled the inclusion criteria. Stratification analyses by comparators and doses of dabigatran etexilate were conducted. Peto odds ratio (ORPETO) values using the fixed-effect model (FEM) for MI, other cardiovascular events, major bleeding, and all-cause mortality were 1.34 (95% CI 1.08 to 1.65, P=0.007), 0.93 (95%CI 0.83 to 1.06, P=0.270), 0.88 (95% CI 0.79 to 0.99, P=0.029), and 0.89 (95% CI 0.80 to 1.00, P=0.041). When compared with warfarin, ORPETO values using FEM were 1.41 (95% CI 1.11 to 1.80, P=0.005), 0.94 (95%CI 0.83 to 1.06, P=0.293), 0.85 (95% CI 0.76 to 0.96, P=0.007), and 0.90 (95% CI 0.81 to 1.01, P=0.061), respectively. In RCTs using the 150-mg BID dosage, the ORPETO values using FEM were 1.45 (95% CI 1.11 to 1.91, P=0.007), 0.95 (95% CI 0.82 to 1.09, P=0.423), 0.92 (95% CI 0.81 to 1.05, P=0.228), and 0.88 (95% CI 0.78 to 1.00, P=0.045), respectively. The results of the 110-mg BID dosage were mainly driven by the RE-LY trial. CONCLUSIONS: This meta-analysis provides evidence that dabigatran etexilate is associated with a significantly increased risk of MI. This increased risk should be considered taking into account the overall benefit in terms of major bleeding and all-cause mortality. [less ▲]

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See detailMetacognitive components in learning to learn approaches
Frenkel, Stéphanie ULg

in International Journal of Psychology : A Biopsychosocial Approach (in press)

Background. Numerous students are having school difficulties linked to the way they learn. Some people speak of a “metacognitive deficit”. We refer to a “sleeping potential” instead. Be it psychologists ... [more ▼]

Background. Numerous students are having school difficulties linked to the way they learn. Some people speak of a “metacognitive deficit”. We refer to a “sleeping potential” instead. Be it psychologists, teachers or parents, all wish to develop their skills in order to help these students. This is the case in primary and secondary school. The EDUCA + project is intended to provide possible solutions. Purpose. The aim of this paper is to present a metacognitive and cognitive theory of learning to learn, which will (a) explain why numerous students are having school difficulties, and (b) predict the success of the EDUCA + project. [less ▲]

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailBayesian versus frequentist methods for estimating disease true prevalence and 4 diagnostic test performance
Sanogo, M; Abatih, E; Saegerman, Claude ULg

in Veterinary Journal (in press)

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See detailAssessment of Toll-like receptor 2, 4 and 9 SNP genotypes in canine sino-nasal aspergillosis
Mercier; Peters, Iain; Farnir, Frédéric ULg et al

in BMC Veterinary Research (in press)

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See detailCompte rendu de G. TOUSSAINT, Kreuz und Knochen. Reliquien zur Zeit der Kreuzzüge, Berlin, 2011.
George, Philippe ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailLa maladie de Lyme entre cadrage infectieux, vectoriel et zoonotique : vers une écologisation des problèmes sanitaires
Massart, Clémence

in VertigO : la Revue Electronique en Sciences de l'Environnement (in press)

This paper is devoted to the qualification of Lyme disease in France. Firt vectorial disease in the northern hemisphere, Lyme diseas is transmitted by a genus of tick called Ixodes (in Europe by Ixodes ... [more ▼]

This paper is devoted to the qualification of Lyme disease in France. Firt vectorial disease in the northern hemisphere, Lyme diseas is transmitted by a genus of tick called Ixodes (in Europe by Ixodes ricinus ; in Asia by Ixodes persulcatus ; in United States and in Canada by Ixodes scapularis). Concerned only with human health and limited to Lyme, a first framing has grown around physicians and patients which are involved in a controversy. Progressively, a second framing has emerged, called vectorial and structured around ecologists, normally not involved in human health. Based on the vector, this framing includes other diseases transmitted by Ixodes ricinus which, during the last 30 years, have been discovered : Tick-Borne Encephalitis, Babesia divergens, Bartonella infection, Tularemia, etc. Linked to these new pathologies, the media coverage of Lyme has finally opened the « vectorial transmission category » – usually associated to mosquitoes and south countries – to ticks and diseases from the north. A third framing dedicated to animal reservoir and called zoonotic is emerging at last. We can see in that framing overlapping a kind of “ecologization” of sanitary issues. [less ▲]

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See detailThe neural basis of temporal order processing in past and future thought
D'Argembeau, Arnaud ULg; Jeunehomme, Olivier ULg; Majerus, Steve ULg et al

in Journal of Cognitive Neuroscience (in press)

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See detailDire et décrire le présent dans les lettres de Francesco Guicciardini (1483-1540)
Miesse, Hélène ULg

in Mosaïque (in press)

Depuis les travaux de Jean-Louis FOURNEL et Jean-Claude ZANCARINI, notamment, il est établi que les auteurs florentins qui vécurent à l’époque des guerres d’Italie identifièrent immédiatement la nouveauté ... [more ▼]

Depuis les travaux de Jean-Louis FOURNEL et Jean-Claude ZANCARINI, notamment, il est établi que les auteurs florentins qui vécurent à l’époque des guerres d’Italie identifièrent immédiatement la nouveauté et le caractère extraordinaire des faits qui bouleversèrent leur époque. Parmi ceux-ci, le célèbre Nicolas Machiavel mais aussi son ami et contemporain, Francesco Guicciardini, qui, si l’histoire littéraire ne lui a pas toujours fait la part belle, retrouve ces dernières années la place qui lui revient dans celle des idées. Auteur, historiographe mais aussi lieutenant des troupes pontificales lors de la Ligue de Cognac et, donc, acteur de l’histoire en train de se jouer, Francesco Guicciardini est en prise directe avec les événements ; dans sa volumineuse correspondance se mêlent petite et grande Histoire. Or, si le substantif et l’adjectif « contemporaneo » existent en italien depuis Dante au moins, Guicciardini n’en fait l’usage ni dans ses œuvres, ni dans ses lettres qui ne comptent aucune occurrence du terme. Partant de ce constat, je me propose, dans mon article, de relever et d’analyser le langage utilisé par Guicciardini pour nommer le moment auquel il vit, en cerner les contours et la façon dont celui-ci se distingue de ce qui précède pour former un moment à part : les expressions qui disent le présent (tempo presente/tempi presenti, questi tempi, medesimi tempi) et celles qui le caractérisent (conditione de' tempi, extraordinario, tempi strani) ou qui expriment le moyen de l’affronter (remedii conformi a’ tempi) seront, dès lors, au centre de mon attention. [less ▲]

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See detailFatal transmission of contagious caprine pleuropneumonia to an Arabian oryx (Oryx leucoryx)
Chaber, AL; Lignereux, L; Al Qassimi, M et al

in Veterinary Microbiology (in press)

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See detailDifferences in species–area relationships among the major lineages of land plants: a macroecological perspective
Patino Llorente, Jairo ULg; Weigelt, P.; Guilhaumon, F. et al

in Global Ecology & Biogeography (in press)

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See detailSens et signification dans l'esthétique de Mallarmé
Durand, Pascal ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (in press), 5

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See detailLa première interprétation heideggérienne de la Monadologie
Pieron, Julien ULg

in Philosophie (in press)

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See detailLa maladie de Lyme entre cadrage infectieux, vectoriel et zoonotique : vers une écologisation des problèmes sanitaires ?
Massart, Clémence ULg

in VertigO : la Revue Electronique en Sciences de l'Environnement (in press)

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ... [more ▼]

Cet article est consacré à la qualification de la maladie de Lyme en France. Principale pathologie vectorielle de l’hémisphère nord, la maladie de Lyme est transmise par une tique du genre Ixodes (Ixodes ricinus en Europe ; Ixodes persulcatus en Asie ; Ixodes scapularis aux États-Unis et au Canada). Les médecins et les malades ont d’abord développé un cadrage infectieux, ancré dans la santé humaine, réservé à Lyme et soumis à une vive controverse. Progressivement, un second cadrage vectoriel s’est structuré autour des entomologistes médicaux puis des écologues, généralement étrangers à la problématique des maladies humaines. Axé sur le vecteur, ce cadrage englobe les autres maladies transmises par Ixodes ricinus en Europe qui, durant les 30 dernières années, n’ont cessé d’être découvertes : bartonnelles, babésioses, tularémie, encéphalite à tiques, etc. Combinée à ces nouvelles pathologies, la notoriété de Lyme a finalement contribué à ouvrir la catégorie « transmission vectorielle » – traditionnellement associée aux moustiques des pays tropicaux – aux tiques et aux maladies de l’hémisphère nord qu’elles véhiculent. Un troisième cadrage axé sur les réservoirs et qualifié de zoonotique commence enfin à se dessiner. Il faut reconnaître dans cette juxtaposition des cadrages – infectieux, vectoriel et zoonotique – une forme d’écologisation des problèmes sanitaires. [less ▲]

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See detailPIXE identification of the provenance of ferruginous rocks used by Neanderthals
Mathis, François ULg; Bodu, Pierre; Dubreuil, Olivier ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (in press)

Les Bossats, near Ormesson, France, is a newly discovered late Mousterian open air site dated to around 47,000 years ago by thermoluminescence. The archaeological level, fossilized by loess, revealed a ... [more ▼]

Les Bossats, near Ormesson, France, is a newly discovered late Mousterian open air site dated to around 47,000 years ago by thermoluminescence. The archaeological level, fossilized by loess, revealed a rich industry based on the discoid mode, associated with numerous fragments of red and yellow iron oxide-rich rocks showing clear traces of powder production (abrasion, striation, scraping), which are exceptional remains for this remote period. Archeological material and geological samples from the close environment were studied by PIXE and by petrographical observations made on thin sections. The geological sources were identified by means of PIXE analyses on two IBA facilities: AGLAE (2 MV tandem) at the C2RMF in Paris and the cyclotron of the IPNAS (University of Liège). We paid particular attention to the comparison of results obtained on both installations by using the same set of geological standards and by a fine evaluation of the limit of detection relative to each trace elements of interest for both experimental set ups. The elemental fingerprint of one geological source of iron-rich concretions corresponds clearly with the archaeological collection. At least, this investigation demonstrates that the colouring materials were minutely selected in the close neighbouring of the site by the Neanderthals. [less ▲]

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See detailL'atlas à l'épreuve de l'image en mouvement (Warburg, Farocki, Didi-Huberman)
Hagelstein, Maud ULg; Hamers, Jérémy ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes ... [more ▼]

Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes pour grandes personnes (G. Didi-Huberman, A. Gisinger, 2012), composée pour partie d’images en mouvement, à la pensée de la table warburgienne comme lieu d’une perpétuelle reconfiguration et d’une nouvelle lisibilité du monde. Se pourrait-il en effet qu’une image en mouvement, prise d’ordinaire dans un continuum clos, se dote, à travers le montage, des mêmes potentialités critiques – c’est-à-dire d’un même pouvoir inquiétant – que l’image fixe offerte au déambulateur de l’atlas ? [less ▲]

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See detailThe “Tuchlein” Colours in the Strasbourg Family Text: Recipes for Anthocyanin Pigments
Neven, Sylvie ULg; Sanyova, Jana

in Dyes in History and Archaeology (in press)

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See detailPhysiological and bio-functional properties of gum arabic: a notable interest for certain human diseases
Eloundou Mballa, Pierre; Goffin, Dorothée ULg; Destain, Jacqueline ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailFirst report of isolation and molecular characterization of bubaline herpesvirus 1 (BuHV1) from Argentinean water buffaloes
Maidana, Silvina; Konrad, José; Craig, Maria et al

in Archives of Virology (in press)

Herpesviruses have mainly co-evolved with their hosts for millions of years. However, bovine herpesvirus 1 (BoHV1) and related ruminant alphaherpesviruses have been reported to cross the species barrier ... [more ▼]

Herpesviruses have mainly co-evolved with their hosts for millions of years. However, bovine herpesvirus 1 (BoHV1) and related ruminant alphaherpesviruses have been reported to cross the species barrier. Bubaline herpesvirus 1 (BuHV1) is an alphaherpesvirus closely related to BoHV1 and BoHV5. According to the serological cross-relationships between ruminant alphaherpesviruses, several surveys have studied the occurrence of BoHV1-related virus infection in wild and domestic ruminant species. Recent studies in Argentina showed an increase in serological prevalence against BoHV1 related viruses in water buffaloes (Bubalus bubalis) population. The aim of this study was to investigate the presence of related ruminant alphaherpesvirus in the Argentinean water buffalo population. BuHV1 was successfully isolated from 5 out of 225 buffaloes analyzed. One isolate was obtained from nasal secretions, and the others were from vaginal swabs. The buffaloes belonged to four different farms located in northeastern Argentina. The isolates were characterized as alphaherpesvirus by direct immunofluorescence using FITC-anti-BoHV1 IgG. Restriction analysis performed with BamHI and BstEII on the complete genome showed differences between the isolates and those from BoHV1 and BoHV5 subtypes. Phylogenetic analysis on both UL27 and US6 showed similarity in tree topology. While three of the isolates grouped together with sequences of BoHV5, two other isolates clustered separately. Genetic analysis of eight concatenated sequences from all isolates and references strains showed high nucleotide sequence identity between BuHV1 and BoHV5. While three of the isolates clustered together with the BoHV5 reference strain, the last two isolates were closely related to an Australian BuHV1 strain. To our knowledge, this is the first report on the isolation and molecular characterization of BuHV1 in South America. Phylogenetic analysis suggested that two different BuHV1 lineages circulate in the Argentinean water buffalo population. [less ▲]

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See detailExpression microarray as a tool to identify candidate blood biomarkers in horses suffering from inflammatory airway disease
Ramery, Eve ULg; Fraipont, Audrey ULg; Art, Tatiana ULg et al

in Veterinary Clinical Pathology (in press)

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires ... [more ▼]

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires sedation. Objectives: The purpose of this study was to identify candidate blood biomarkers of IAD using species-specific expression microarrays. Methods: Horse Gene Expression Microarrays were used to investigate global mRNA expression in circulating leukocytes from healthy and IAD-affected standardbreds and endurance horses. Results: Nine genes were significantly differentially regulated in standardbreds and 61 in endurance horses (P < 0.001). These genes were mainly related to inflammation (eg. ALOX15B, PLA2G12B and PENK), oxidant/antioxidant balance (eg. DUOXA2 and GSTO1-1) and stress (eg. V1aR, GRLF1, Homer-2 and MAOB). DUOXA2, ALOX15B, PLA2G12B, MAOB and GRLF1 variations of expression were further validated by RT-qPCR. The deregulation of the oxidant/antioxidant balance was demonstrated at the protein level by an increase of glutathione peroxidase (GPx) activity in heparinised whole blood of IAD-affected standardbreds (P = 0.0025) and endurance horses (P = 0.0028). There was good correlation (r = 0.7354) between BAL neutrophil percentage and whole blood GPx activity in all horses. Conclusions: There is accumulating evidence that, even when systemic clinical signs are not evident, circulating leukocyte gene expression can reflect responses of other tissues, leading to potential diagnostic applications in the future. Although not specific for IAD, whole blood GPx activity appears to reflect BAL neutrophil percentage. This finding should be further assessed by testing a larger number of horses. [less ▲]

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See detailEffect of improved feeding and housing, Friesian blood level and parity on milk production of Ankole x Friesian cows
Kibwana, Denise Katungu; Makumyaviri, A.M.; Hornick, Jean-Luc ULg

in Pakistan Veterinary Journal (in press)

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk ... [more ▼]

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk consumption in population. An improved farming system, including feed supplementation, Friesian cross-breeding and the sheltering of animals in stalls at night, was studied to evaluate its effect on milk production by Ankole x Friesian crossbreds. The study was performed in Beni, D.R. Congo, on two groups of 15 animals (control group-CoG and improved group-IG), homogeneous according to Friesian blood and parity levels. The improved system, Friesian blood and parity levels increased significantly milk production (P<0.001). Farming system increased milk production by 1.6 l/d (5.2 l/d vs 6.8 l/d respectively in CoG and IG). Milk production ranged from 5.3±0.04 l/d to 6.6±0.02 l/d and from 4.9±0.02 l/d to 7.2±0.02 l/d according, respectively, to Friesian blood level and parity. A significant interaction was observed between farming system and Friesian blood level, and between farming system and parity (P<0.001). The two groups were characterized by a fair adaptation to forage availability associated to climatic factors. The study showed the importance of genetic and environmental factors on the milk production of crossbred dairy cows of the region. [less ▲]

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See detailSimultaneous enforcement of constraints at position and velocity levels in the nonsmooth generalized-alpha scheme
Bruls, Olivier ULg; Acary, Vincent; Cardona, Alberto

in Computer Methods in Applied Mechanics & Engineering (in press)

This paper presents a formalism for the transient simulation of nonsmooth dynamic mechanical systems composed of rigid and flexible bodies, kinematic joints and frictionless contact conditions. The ... [more ▼]

This paper presents a formalism for the transient simulation of nonsmooth dynamic mechanical systems composed of rigid and flexible bodies, kinematic joints and frictionless contact conditions. The proposed algorithm guarantees the exact satisfaction of the bilateral and unilateral constraints both at position and velocity levels. Thus, it significantly differs from penalty techniques since no penetration is allowed. The numerical scheme is obtained in two main steps. Firstly, a splitting method is used to isolate the contributions of impacts, which shall be integrated with only first-order accuracy, from smooth contributions which can be integrated using a higher order scheme. Secondly, following the idea of Gear, Gupta and Leimkuhler, the equations of motion are reformulated so that the bilateral and unilateral constraints appear both at position and velocity levels. After time discretization, the equations of motion involve two complementarity conditions and it can be solved at each time step using a monolithic semi-smooth Newton method. The numerical behaviour of the proposed method is studied and compared to other approaches for a number of numerical examples. It is shown that the formulation offers a unified and valid approach for the description of contact conditions between rigid bodies as well as between flexible bodies. [less ▲]

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