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See detailn < 2 Allowed Transitions in Neutral Sulfur within in the Visible and Infrared Spectral Ranges
Biémont, Emile ULg; Quinet, Pascal ULg; Zeippen, C. J.

in Astronomy and Astrophysics. Supplement Series (1993), 102

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See detailN content of phloem and xylem exudates during the transition to flowering in Sinapis alba and Arabidopsis thaliana
Corbesier, Laurent; Havelange, Andrée ULg; Lejeune, Pierre et al

in Plant, Cell & Environment (2001), 24

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower ... [more ▼]

The involvement of nitrogenous substances in the transition to flowering was investigated in Sinapis alba and Arabidopsis thaliana (Columbia). Both species grown in short days (SD) are induced to flower by one long day (LD). In S. alba, the phloem sap (leaf and apical exudates) and the xylem sap (root exudate) were analysed in LD versus SD. In A. thaliana, only the leaf exudate could be analysed but an alternative system for inducing flowering without day-length extension was used: the displaced SD (DSD). Significant results are: (i) in both species, the leaf exudate was enriched in Gln during the inductive LD, at a time compatible with export of the floral stimulus; (ii) in S. alba, the root export of amino acids decreased in LD, whereas the nitrate remained unchanged - thus the extra-Gln found in the leaf exudate should originate from the leaves; (iii) extra-Gln was also found very early in the apical exudate of S. alba in LD, together with more Glu; (iv) in A. thaliana induced by one DSD, the leaf export of Asn increased sharply, instead of Gln in LD. This agrees with Asn prevalence in C-limited plants. The putative role of amino acids in the transition to flowering is discussed. [less ▲]

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See detailN N scattering phase shifts in a chiral constituent quark model
Bartz, Daniel ULg; Stancu, Floarea ULg

in Nuclear Physics A (2001), A688

We study the nucleon-nucleon interaction within a chiral constituent quark model which reproduces succesfully the baryon spectra. We calculate the $^3S_1$ and $^1S_0$ phase shifts by using the resonating ... [more ▼]

We study the nucleon-nucleon interaction within a chiral constituent quark model which reproduces succesfully the baryon spectra. We calculate the $^3S_1$ and $^1S_0$ phase shifts by using the resonating group method. They clearly indicate the presence of a strong repulsive interaction at short distance, due to the spin-flavour symmetry of the quark-quark interaction and of the quark interchange between the two interacting nucleons. A $\sigma$-meson exchange quark-quark interaction, providing a medium-range attraction, helps to get closer to the experimental phase shifts. [less ▲]

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See detailThe N- and C-termini of the tricarboxylate carrier are exposed to the cytoplasmic side of the inner mitochondrial membrane.
Capobianco, L.; Bisaccia, F.; Michel, A. et al

in FEBS Letters (1995), 357

Polyclonal antibodies were raised in rabbits against two synthetic peptides corresponding to the N- and C-terminal regions of the rat-liver mitochondrial tricarboxylate carrier. ELISA tests performed with ... [more ▼]

Polyclonal antibodies were raised in rabbits against two synthetic peptides corresponding to the N- and C-terminal regions of the rat-liver mitochondrial tricarboxylate carrier. ELISA tests performed with intact and permeabilized rat-liver mitoplasts showed that both anti-N-terminal and anti-C-terminal antibodies bind only to the cytoplasmic surface of the inner membrane, indicating that both termini of the membrane-bound tricarboxylate carrier are exposed to the mitochondrial intermembrane space. Furthermore, tryptic digestion of intact mitoplasts markedly decreased the binding of anti-N-terminal and anti-C-terminal antibodies to the tricarboxylate carrier. These results are consistent with an arrangement of the tricarboxylate carrier monomer into an even number of transmembrane segments, with the N- and C-termini protruding toward the cytosol. [less ▲]

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See detailN-(3-Phenoxy-4-pyridinio)methanesulfonamidate
Michaux, C.; Charlier, C.; Julémont, F. et al

in Acta Crystallographica (2002)

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See detailN-acetylcysteine lacks universal inhibitory activity against influenza A viruses.
Garigliany, Mutien-Marie ULg; Desmecht, Daniel ULg

in Journal of negative results in biomedicine (2011), 10(1), 5

ABSTRACT: N-acetylcysteine (NAC) has been recently proposed as an adjuvant therapeutic drug for influenza pneumonia in humans. This proposal is based on its ability to restrict influenza virus replication ... [more ▼]

ABSTRACT: N-acetylcysteine (NAC) has been recently proposed as an adjuvant therapeutic drug for influenza pneumonia in humans. This proposal is based on its ability to restrict influenza virus replication in vitro and to attenuate the severity of the disease in mouse models. Although available studies were made with different viruses (human and avian), published information related to the anti-influenza spectrum of NAC is scarce. In this study, we show that NAC is unable to alter the course of a fatal influenza pneumonia caused by inoculation of a murinized swine H1N1 influenza virus. NAC was indeed able to inhibit the swine virus in vitro but far less than reported for other strains. Therefore, susceptibility of influenza viruses to NAC appears to be strain-dependent, suggesting that it cannot be considered as a universal treatment for influenza pneumonia. [less ▲]

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See detailN-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.
Goffin, Eric ULg; Lamoral-Theys, Delphine; Tajeddine, Nicolas et al

in European Journal of Medicinal Chemistry (2012), 54

A series of chroman derivatives previously reported as potassium channel openers, as well as some newly synthesized simplified structures, were examined for their in vitro effects on the growth of three ... [more ▼]

A series of chroman derivatives previously reported as potassium channel openers, as well as some newly synthesized simplified structures, were examined for their in vitro effects on the growth of three human high-grade glioma cell lines: U373, T98G, and Hs683. Significant in vitro growth inhibitory activity was observed with 2,2-dimethylchroman-type nitro-substituted phenylthioureas, such as compounds 4o and 4p. Interestingly, most tested phenylureas were found to be slightly less active, but more cell selective (normal versus tumor glial cells, such as 3d, 3e, and 3g), thus less toxic, than the corresponding phenylthioureas. No significant differences were observed in terms of chroman-derivative-induced growth inhibitory effects between glioma cells sensitive to pro-apoptotic stimuli (Hs683 glioma cells) and glioma cells associated with various levels of resistance to pro-apoptotic stimuli (U373 and T98G glioma cells), a feature that suggests non-apoptotic-mediated growth inhibition. Flow cytometry analyses confirmed the absence of pro-apoptotic effects for phenylthioureas and phenylureas when analyzed in U373 glioma cells and demonstrated U373 cell cycle arrest in the G0/G1 phase. Computer-assisted phase-contrast videomicroscopy revealed that 3d and 3g displayed cytostatic effects, while 3e displayed cytotoxic ones. As a result, this work identified phenylurea-type 2,2-dimethylchromans as a new class of antitumor agents to be further explored for an innovative therapeutic approach for high-grade glioma and/or for a possible new mechanism of action. [less ▲]

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See detailN-heterocyclic carbene catalyzed carba-, sulfa-, and phospha-Michael additions with NHC·CO2 adducts as precatalysts
Hans, Morgan ULg; Delaude, Lionel ULg; Rodriguez, Jean et al

in Journal of Organic Chemistry (2014), 79(6), 2758-2764

N-heterocyclic carbene catalyzed Michael additions have been revisited with 1,3-dialkyl- or 1,3-diarylimidazol(in)ium-2-carboxylates, that is, NHC·CO2 adducts, as the source of the free NHC catalysts in ... [more ▼]

N-heterocyclic carbene catalyzed Michael additions have been revisited with 1,3-dialkyl- or 1,3-diarylimidazol(in)ium-2-carboxylates, that is, NHC·CO2 adducts, as the source of the free NHC catalysts in solution. Using these precatalysts, a number of efficient carba-, sulfa-, and phospha-Michael additions were achieved very conveniently, without the need for an external strong base to generate the NHC by deprotonation of an azolium salt. To further expand the scope of the procedure, some NHC-catalyzed sulfa-Michael/aldol organocascades were also investigated. [less ▲]

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See detailN-heterocyclic carbene ruthenium complexes: Synthesis and catalytic properties
Dragutan, Ileana; Dragutan, Valerian; Delaude, Lionel ULg et al

in Revue Roumaine de Chimie (2007), 52(11), 1013-1025

Synthesis of imidazol(in)-2-ylidene ruthenium complexes relevant for metathesis and related catalytic processes is described. As an attractive alternative of importance for practical applications, the in ... [more ▼]

Synthesis of imidazol(in)-2-ylidene ruthenium complexes relevant for metathesis and related catalytic processes is described. As an attractive alternative of importance for practical applications, the in situ generation of new NHC ruthenium precatalysts, starting from the easily accessible imidazolium and imidazolinium salts, ruthenium dimer [RuCl2(p-cymene)](2) and a base, is reported in detail. The new NHC family of ruthenium complexes offers great promise as metathesis precatalysts enjoying a wide application profile in organic and polymer synthesis. [less ▲]

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See detailN-Heterocyclic carbenes as highly efficient ancillary ligands in homogeneous and immobilized metathesis ruthenium catalytic systems
Dragutan, Ileana; Dragutan, Valerian; Delaude, Lionel ULg et al

in ARKIVOC (2005), (Part 10), 206-253

This general overview focuses on novel N-heterocyclic carbene (NHC) Ru complexes, now at the forefront of research in metathesis chemistry, and on their derived multiple applications in targeted organic ... [more ▼]

This general overview focuses on novel N-heterocyclic carbene (NHC) Ru complexes, now at the forefront of research in metathesis chemistry, and on their derived multiple applications in targeted organic, polymeric and natural compound synthesis. This outstanding, large class of ruthenium precatalysts combines high activity and selectivity with increased stability and good tolerance towards organic functionalities, air and moisture. The NHC ancillary ligands allow manipulation of the catalytic performance through adjustment of electronic and steric parameters in the ruthenium coordination sphere, facilitate introduction of chiral motifs, and enable convenient immobilization of homogeneous initiators onto solid supports. A broad spectrum of practical applications is discussed. [less ▲]

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See detailN-REM sleep slow oscillations amplitude and density in the young and middle-aged men and women
Viens, I; Lafortune, M; Poirier, G et al

Poster (2009, April)

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See detailN-REM sleep slow oscillations amplitude and density in the young and middle-aged men and women
Viens, I; Lafortune, M; Poirier, G et al

in Sleep (2009), 32(Suppl. 1),

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See detailThe N-terminal 12 residue long peptide of HIV gp41 is the minimal peptide sufficient to induce significant T-cell-like membrane destabilization in vitro.
Charloteaux, Benoît ULg; Lorin, A.; Crowet, Jean-Marc ULg et al

in Journal of molecular biology (2006), 359(3), 597-609

Here, we predicted the minimal N-terminal fragment of gp41 required to induce significant membrane destabilization using IMPALA. This algorithm is dedicated to predict peptide interaction with a membrane ... [more ▼]

Here, we predicted the minimal N-terminal fragment of gp41 required to induce significant membrane destabilization using IMPALA. This algorithm is dedicated to predict peptide interaction with a membrane. We based our prediction of the minimal fusion peptide on the tilted peptide theory. This theory proposes that some protein fragments having a peculiar distribution of hydrophobicity adopt a tilted orientation at a hydrophobic/hydrophilic interface. As a result of this orientation, tilted peptides should disrupt the interface. We analysed in silico the membrane-interacting properties of gp41 N-terminal peptides of different length derived from the isolate BRU and from an alignment of 710 HIV strains available on the Los Alamos National Laboratory. Molecular modelling results indicated that the 12 residue long peptide should be the minimal fusion peptide. We then assayed lipid-mixing and leakage of T-cell-like liposomes with N-terminal peptides of different length as first challenge of our predictions. Experimental results confirmed that the 12 residue long peptide is necessary and sufficient to induce membrane destabilization to the same extent as the 23 residue long fusion peptide. In silico analysis of some fusion-incompetent mutants presented in the literature further revealed that they cannot insert into a modelled membrane correctly tilted. According to this work, the tilted peptide model appears to explain at least partly the membrane destabilization properties of HIV fusion peptide. [less ▲]

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See detailThe N-Terminal Juxtamembranous Domain Of Kcnq1 Is Critical For Channel Surface Expression - Implications In The Romano-Ward Lqt1 Syndrome
Dahimene, S.; Alcolea, S.; Naud, P. et al

in Circulation Research (2006), 99(10), 1076-83

arrhythmias in newborn children and adolescents but the cellular mechanisms involved in this dramatic issue remain, however, to be discovered. Here, we analyzed the trafficking of a series of N-terminal ... [more ▼]

arrhythmias in newborn children and adolescents but the cellular mechanisms involved in this dramatic issue remain, however, to be discovered. Here, we analyzed the trafficking of a series of N-terminal truncation mutants and identified a critical trafficking motif of KCNQ1. This determinant is located in the juxtamembranous region preceding the first transmembrane domain of the protein. Three mutations (Y111C, L114P and P117L) implicated in inherited Romano-Ward LQT1 syndrome, are embedded within this domain. Reexpression studies in both COS-7 cells and cardiomyocytes showed that the mutant proteins fail to exit the endoplasmic reticulum. KCNQ1 subunits harboring Y111C or L114P exert a dominant negative effect on the wild-type KCNQ1 subunit by preventing plasma membrane trafficking of heteromultimeric channels. The P117L mutation had a less pronounced effect on the trafficking of heteromultimeric channels but altered the kinetics of the current. Furthermore, we showed that the trafficking determinant in KCNQ1 is structurally and functionally conserved in other KCNQ channels and constitutes a critical trafficking determinant of the KCNQ channel family. Computed structural predictions correlated the potential structural changes introduced by the mutations with impaired protein trafficking. In conclusion, our studies unveiled a new role of the N-terminus of KCNQ channels in their trafficking and its implication in severe forms of LQT1 syndrome. [less ▲]

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See detailN-tert-butyl-N'-[5-cyano-2-(4-methylphenoxy)phenylsulfonyl]urea, a new TXA₂ receptor antagonist
Bambi Nyanguile, S.M.; Mangwala Kimpende, P.; Pirotte, Bernard ULg et al

in Acta Crystallographica Section C-Crystal Structure Communications (2013), 69

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See detailN-type and p-type ultra shallow junctions by atomic layer epitaxy and laser anneal
Nguyen, Ngoc Duy ULg; Souriau, Laurent; Shimizu, Yasuo et al

Conference (2011)

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See detail"N-VA wil federale staat uitkleden" (interview de presse)
Behrendt, Christian ULg

Article for general public (2011)

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