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See detailG protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors
Maïga, Arhamatoulaye; Mourier, Gilles; Quinton, Loïc ULg et al

in Toxicon (2012), 59

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug ... [more ▼]

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug candidates. We looked for identifying novel animal toxins active against G protein-coupled receptors (GPCR), the most frequently exploited class of treatment targets, with the aim to develop novel research tools and drug candidates. Screening of green mamba (Dendroaspis angusticeps) venom against adrenoceptors identified two novel venom peptides. r-Da1a shown an affinity of 0.35 nM for the a1a-AR while r-Da1b displayed affinities between 14 and 73 nM for the three a2-ARs. These two venom peptides have sequences similar to those of muscarinic toxins and belong to the three-finger-fold protein family. a1a-AR is the primary target for the treatment of prostate hypertrophy. In vitro and in vivo tests demonstrated that r-Da1a reduced prostatic muscle tone as efficiently as tamsulosin (an antagonist presently used), but with fewer cardiovascular side effects. a2-ARs are the prototype of GPCRs not currently used as treatment targets due to a lack of specific ligands. Blockage of these receptors increases intestinal motility, which may be compromised by abdominal surgery and reduces orthosteric hypotension. In vitro and in vivo tests demonstrated that r-Da1b antagonizes a2-ARs in smooth muscles and increased heart rate and blood catecholamine concentrations. These results highlight possible exploitation of r-Da1a and r-Da1b in important pathologies. [less ▲]

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See detail(G)astronomie - Barres météoritiques
Nazé, Yaël ULg

Article for general public (2013)

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See detail(G)astronomie - Big bang cookies
Nazé, Yaël ULg

Article for general public (2013)

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See detail(G)astronomie - Comète glacée
Nazé, Yaël ULg

Article for general public (2012)

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See detail(G)astronomie - Dip martien
Nazé, Yaël ULg

Article for general public (2013)

See detail(G)astronomie - Smoothie interstellaire
Nazé, Yaël ULg

Article for general public (2013)

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See detail(G)astronomie - Soufflé structurel
Nazé, Yaël ULg

Article for general public (2013)

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See detail(G)astronomie - Stoemp céleste
Nazé, Yaël ULg

Article for general public (2011)

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See detail(G)astronomie - Tarte Titan
Nazé, Yaël ULg

Article for general public (2011)

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See detailG-Cube 2.0 : Un logiciel de cubage et de constitution de lots de bois
Handerek, Daphné ULg; Quevauvillers, Samuel ULg; Hebert, Jacques ULg et al

in Forêt Wallonne (2013), (124), 20-27

G-Cube, le logiciel de cubage et de constitution de lots de bois développé par Gembloux Agro-Bio Tech, fait peau neuve. Cette version 2.0 voit arriver des nouveautés parmi lesquelles : la géolocalisation ... [more ▼]

G-Cube, le logiciel de cubage et de constitution de lots de bois développé par Gembloux Agro-Bio Tech, fait peau neuve. Cette version 2.0 voit arriver des nouveautés parmi lesquelles : la géolocalisation des arbres cubés, le croisement des données avec des listes de prix personnelles ou standardisées, ou encore l’abandon de l’environnement Excel au profit d’une interface autonome. [less ▲]

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See detailG-Cube version 2.3.2 - Logiciel de cubage et de lotissement d'arbres
Lejeune, Philippe ULg; Quevauvillers, Samuel ULg; Handerek, Daphné ULg

Software (2014)

This software is dedicated to the volume estimation of tree list using as set of volume equations adapted to belgian forest species. A specific module takes in charge the creation and the price ... [more ▼]

This software is dedicated to the volume estimation of tree list using as set of volume equations adapted to belgian forest species. A specific module takes in charge the creation and the price calculation of trees assortments [less ▲]

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See detailg-Mode Oscillations in Hot B Subdwarf Stars
Charpinet, Stéphane; Van Grootel, Valérie ULg; Fontaine, Gilles et al

in Astronomical Society of the Pacific Conference Series (2013, December), 479

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact ... [more ▼]

Observations from space with CoRoT and Kepler have revealed the rich pulsation spectra that characterize the long period hot B subdwarf (sdB) pulsators of the V1093 Her type. These evolved and compact helium core burning stars can develop low amplitude oscillations with periods in the range ∼ 1 − 4 hours that correspond to low degree, mid to high order g-modes. These modes have the property to penetrate deep inside the star, down to the boundary of the central convective core. They are consequently particularly interesting as asteroseismic probes. Here we briefly review how the g-modes behave in sdB stars, focusing in particular on the seismic signatures coming from the core itself. We also briefly summarize the first seismic results obtained from space data in pioneering efforts to exploit the potential of long period sdB pulsators as deep probes of the core structure. [less ▲]

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See detailg-mode pulsations in slowly pulsating B stars
De Cat, P.; Daszynska-Daszkiewicz, J.; Briquet, Maryline ULg et al

in IAU Colloq. 193: Variable Stars in the Local Group (2004, May 01)

In this paper, we give an updated overview of the observed characteristics of g-mode pulsations in slowly pulsating B stars. These characteristics are based on the combined results of linear nonadiabatic ... [more ▼]

In this paper, we give an updated overview of the observed characteristics of g-mode pulsations in slowly pulsating B stars. These characteristics are based on the combined results of linear nonadiabatic analysis of the oscillations and a photometric and spectroscopic mode identification for a sample of 13 members. For 4 stars, at least one mode is stable in all the considered theoretical models. [less ▲]

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See detailG-mode trapping and period spacings in hot B subdwarf stars
Charpinet, Stéphane; Van Grootel, Valérie ULg; Brassard, Pierre et al

in Proceedings of the International Astronomical Union (2014, February), 301

Hot B subdwarfs (sdB) are hot and compact helium core burning stars of nearly half a solar mass that can develop pulsational instabilities driving acoustic and/or gravity modes. These evolved stars are ... [more ▼]

Hot B subdwarfs (sdB) are hot and compact helium core burning stars of nearly half a solar mass that can develop pulsational instabilities driving acoustic and/or gravity modes. These evolved stars are expected to be chemically stratified with an almost pure hydrogen envelope surrounding a helium mantle on top of a carbon/oxygen enriched core. However, the sdB stars pulsating in g-modes show regularities in their observed period distributions that, surprisingly (at first sight), are typical of the behavior of high order g-modes in chemically homogeneous (i.e., non-stratified) stars. This led to a claim that hot B subdwarfs could be much less chemically stratified than previously thought. Here, we reinvestigate trapping effects affecting g-modes in sdB stars. We show that standard stratified models of such stars can also produce nearly constant period spacings in the low frequency range similar to those found in g-mode spectra of sdB stars monitored with Kepler. [less ▲]

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See detailG-Quadruplex DNA Assemblies: Loop Length, Cation Identity, and Multimer Formation
Smargiasso, Nicolas ULg; Rosu, Frédéric ULg; Hsia, Wei et al

in Journal of the American Chemical Society (2008), 130(31), 10208-10216

G-rich DNA sequences are able to fold into structures called G-quadruplexes. To obtain general trends in the influence of loop length on the structure and stability of G-quadruplex structures, we studied ... [more ▼]

G-rich DNA sequences are able to fold into structures called G-quadruplexes. To obtain general trends in the influence of loop length on the structure and stability of G-quadruplex structures, we studied oligodeoxynucleotides with random bases in the loops. Sequences studied are dGGGWiGGGWjGGGWkGGG, with W = thymine or adenine with equal probability, and i, j, and k comprised between 1 and 4. All were studied by circular dichroism, native gel electrophoresis, UV-monitored thermal denaturation, and electrospray mass spectrometry, in the presence of 150 mM potassium, sodium, or ammonium cations. Parallel conformations are favored by sequences with short loops, but we also found that sequences with short loops form very stable multimeric quadruplexes, even at low strand concentration. Mass spectrometry reveals the formation of dimers and trimers. When the loop length increases, preferred quadruplex conformations tend to be more intramolecular and antiparallel. The nature of the cation also has an influence on the adopted structures, with K+ inducing more parallel multimers than NH4+ and Na+. Structural possibilities are discussed for the new quadruplex higher-order assemblies. [less ▲]

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See detailG-quadruplexes in telomeric repeats are conserved in a solvent-free environment
Baker, Erin Shammel; Bernstein, Summer L; Gabelica, Valérie ULg et al

in International Journal of Mass Spectrometry (2006), 253(3), 225-237

The structural properties of G-quadruplex forming sequences. such as the human telomeric repeat d(T(2)AG(3))(n), are of great interest due to their role in cancer and cellular aging. To determine if G ... [more ▼]

The structural properties of G-quadruplex forming sequences. such as the human telomeric repeat d(T(2)AG(3))(n), are of great interest due to their role in cancer and cellular aging. To determine if G-quadruplexes are present in a solvent-free environment. different lengths of the telomeric repeat d(T(2)AG(3))(n) (where n = 1, 2, 4 and 6) and dTG(4)T were investigated with mass specteometry, ion mobility and molecular dynamics calculations. Nano-ESI-MS illustrated quadruples stoichiometries compatible with G-quadruplex Structure.; for each sequence, with dT(2)AG(3) and dTG(4)T forming 4-strand complexes with two and three NH4+ adducts. d(T(2)AG(3))(2) a 2-strand complex. and d(T(2)AG(3))(4) and d(T(2)AG(3))(6) remaining single-stranded. Experimental cross sections were obtained for all species using ion mobility method.,. In all case.,. these could be quantitatively matched to model cross sections with specific strand orientations (parallel/antiparallel) and structures. For each species, the solvent-free structures agreed with the solution CD measurements, but the ion mobility/modeling procedure often gave Much more detailed structural information. (C) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailG.W.F. Hegel: la philosophie du droit
Seba, Jean-Renaud ULg

Conference given outside the academic context (2010)

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See detailG1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.
Doumont, Gilles; Martoriati, Alain; Beekman, Chantal et al

in EMBO Journal (2005), 24(17), 3093-3103

In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new direct ... [more ▼]

In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new direct p53 target, Ptprv (or ESP), encoding a transmembrane tyrosine phosphatase. Ptprv transcription is dramatically and preferentially increased in cultured cells undergoing p53-dependent cell cycle arrest, but not in cells undergoing p53-mediated apoptosis. This observation was further confirmed in vivo using a Ptprv null-reporter mouse line. A p53-responsive element is present in the Ptprv promoter and p53 is recruited to this site in vivo. Importantly, while p53-dependent apoptosis is intact in mice lacking Ptprv, Ptprv-null fibroblasts and epithelial cells of the small intestine are defective in G1 checkpoint control. Thus, Ptprv is a new direct p53 target and a key mediator of p53-induced cell cycle arrest. Finally, Ptprv loss enhances the formation of epidermal papillomas after exposure to chemical carcinogens, suggesting that Ptprv acts to suppress tumor formation in vivo. [less ▲]

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See detailLe G1000
Reuchamps, Min ULg

Article for general public (2011)

Le G1000 est une initiative citoyenne dont l’ambition est d’être un nouvel outil démocratique, complémentaire aux élections et plus généralement à la démocratie représentative. Concrètement, le projet est ... [more ▼]

Le G1000 est une initiative citoyenne dont l’ambition est d’être un nouvel outil démocratique, complémentaire aux élections et plus généralement à la démocratie représentative. Concrètement, le projet est conçu comme une fusée à trois étages. D’abord, et elle a été lancée début juillet, une consultation en ligne de grande envergure pour connaître les sujets de préoccupation des habitants de ce pays qui pourront alors être discutés lors de l’étape suivante. Ensuite, une journée de délibération le 11 novembre 2011 rassemblera 1000 personnes, sélectionnées de manière indépendante et aléatoire afin de refléter – le plus possible – la diversité de notre pays, à Tour & Taxis à Bruxelles. Rassemblés autour de 100 tables de 10 personnes, les citoyens choisis au hasard et préalablement armés des connaissances techniques nécessaires à la discussion tenteront d’élaborer quelques propositions relatives aux thèmes jugés prioritaires. Enfin, un plus petit groupe de citoyens (un G24), dans les mois qui suivent, affinera ces propositions pour formuler des suggestions concrètes à l’issue de trois week-ends de délibération. Mais le G1000, par son caractère inédit, ne manque pas de soulever des interrogations qui ne peuvent être négligées. Des choix importants ont été faits par les initiateurs et ceux-ci méritent d’être expliqués. Ils concernent le financement de l’initiative, la sélection des thèmes et des participants et enfin le but même du G1000. [less ▲]

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