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See detailAutoimmune syndrome after neonatal induction of tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity
Merino, J.; Schurmans, Stéphane ULg; Wen, L. et al

in Clinical & Experimental Immunology (1990), 79

The injection of (C57BL/6 x BALB/c) F1 spleen cells into BALB/c newborn mice leads to activation of persisting F1 donor B cells and development of a lupus-like syndrome in tolerized BALB/c mice. This ... [more ▼]

The injection of (C57BL/6 x BALB/c) F1 spleen cells into BALB/c newborn mice leads to activation of persisting F1 donor B cells and development of a lupus-like syndrome in tolerized BALB/c mice. This syndrome is characterized by hypergammaglobulinaemia, high levels of anti-DNA and anti-Sm antibodies, circulating immune complexes and deposits of immunoglobulin in renal glomeruli. The role of donor T cells in this model was investigated by injecting the newborn mice with F1 cells depleted in different T cell subsets by using specific monoclonal antibodies (MoAbs). Tolerance, as shown by an absence of H-2b-specific CTL alloreactivity and persistence of immunoglobulin bearing the donor allotype were observed in mice injected with F1 cells previously depleted in the CD4+ and/or CD8+ T cell subsets as well as in those which received Thy-1+-depleted F1 spleen cells. In these mice, a typical autoimmune syndrome was found, including splenomegaly and lymphadenopathy, anti-ssDNA and anti-aortic myosin IgG antibodies and renal deposition of immunoglobulin. However, some quantitative changes were seen: the levels of anti-aortic myosin antibodies were lower in mice tolerized with CD4+-depleted F1 cells than in those receiving untreated F1 cells. Conversely, higher levels of these autoantibodies were observed in mice tolerized with CD8+-depleted F1 cells. These results suggest that mature donor T cells are not necessary neither for the establishment of neonatal tolerance to alloantigens nor for the activation of F1 donor B cells in the production of the autoimmune syndrome in tolerant mice, but they may contribute in the regulation of the expression of autoreactive B cell clones. [less ▲]

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See detailAutoimmune syndrome after neonatal induction of tolerance to alloantigens: analysis of the specificity and of the cellular and genetic origin of autoantibodies
Schurmans, Stéphane ULg; Merino, J.; Qin, H. et al

in Autoimmunity (1991), 9

BALB/c mice neonatally injected with 10(8) semiallogeneic (C57BL/6 x BALB/c)F1 spleen cells become tolerant to the H-2b alloantigens, but also develop a wide range of autoimmune manifestations ... [more ▼]

BALB/c mice neonatally injected with 10(8) semiallogeneic (C57BL/6 x BALB/c)F1 spleen cells become tolerant to the H-2b alloantigens, but also develop a wide range of autoimmune manifestations characteristic of systemic lupus erythematosus (SLE). Indeed, in these mice, the presence of a hypergammaglobulinaemia, autoantibodies--including anti-ssDNA, anti-platelet, thymocytotoxic and rheumatoid factor antibodies--circulating immune complexes, cryoglobulins as well as renal glomerular deposition of immunoglobulins have been observed. In this study, we have shown that the allogenic effect and B cell chimaerism which characterize these F1 cell-injected mice is associated with the expression of a large spectrum of autoantibodies, including anti-ssDNA and anti-cytoskeleton antibodies, and that these autoantibodies are not multispecific. We took advantage of the fact that, in this model, autoantibodies are exclusively produced by F1 donor B cells to inject newborn BALB/c mice with F1 Xid spleen cells lacking the CD5+ B cell subset. Injection of 2 x 10(8) F1 Xid spleen cells triggers the production of anti-ssDNA as well as anti-BrMRBC antibodies, and these mice developed tissue lesions. Finally, analysis of the VH gene family expressed by monoclonal autoantibodies derived from F1 cell-injected mice showed that they used the 2 largest families J558 and 7183. These results suggest that the allogenic effect and B cell chimerism which characterize the neonatal induction of tolerance to MHC alloantigens is associated with the selective triggering of autoreactive B cells producing monospecific IgG autoantibodies. They also imply that upon stimulation by persisting alloreactive CD4+ T cells, either CD5- B cells are able to produce autoantibodies or autoantibody-producing CD5+ B cells can differentiate from Xid spleen cells [less ▲]

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See detailAutoimmune thyroid diseases in early childhood three case reports
GUFFINS, A; HARVENGT, Julie ULg; LUYCKX, F et al

Poster (2015, March)

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See detailAutoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Vang, Torkel; Congia, Mauro; Macis, Maria Doloretta et al

in Nature genetics (2005), 37(12), 1317-9

A SNP in the gene PTPN22 is associated with type 1 diabetes, rheumatoid arthritis, lupus, Graves thyroiditis, Addison disease and other autoimmune disorders. T cells from carriers of the predisposing ... [more ▼]

A SNP in the gene PTPN22 is associated with type 1 diabetes, rheumatoid arthritis, lupus, Graves thyroiditis, Addison disease and other autoimmune disorders. T cells from carriers of the predisposing allele produce less interleukin-2 upon TCR stimulation, and the encoded phosphatase has higher catalytic activity and is a more potent negative regulator of T lymphocyte activation. We conclude that the autoimmune-predisposing allele is a gain-of-function mutant. [less ▲]

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See detailAutoimmunity and pregnancy: Theory and practice
Geenen, Vincent ULg; PERRIER d'HAUTERIVE, Sophie ULg; Puit, M. et al

in Acta Clinica Belgica (2002), 57(6), 317-324

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See detailAutoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: A prospective cohort study
Vermeire, S.; Noman, M.; Van Assche, G. et al

in Gastroenterology (2003), 125(1), 32-39

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and ... [more ▼]

Background & Aims: Infliximab therapy is an effective approach to treating Crohn's disease. Development of antinuclear antibodies has been described in patients treated, but the size of the problem and the relationship with autoimmunity have not been investigated. We investigated the occurrence of antinuclear antibodies in 125 consecutive Crohn's disease patients and studied the relationship with symptoms of autoimmunity. Methods: Autoantibodies and clinical data were investigated before and 1, 2, and 3 months after infliximab infusion. If antinuclear antibodies were greater than or equal to1:80, further study of double-stranded DNA, single-stranded DNA, histones, and ENA was performed. Results: Cumulative antinuclear antibody incidence at 24 months was 71 of 125 (56.8%). Almost half of these patients developed antinuclear antibodies after the first infusion, and >75% became antinuclear antibody positive after fewer than 3 infusions. So far, only :15 of 71 patients have become seronegative, after a median of 12 months. Of 43 antinuclear antibody-positive patients who were further subtyped, 14 of 43 (32.6%) had double-stranded DNA, 17 (39.5%) had single-stranded DNA, 9 (20.9%) had antihistone, and 0% were ENA positive. Two patients (both antihistone and double-stranded DNA positive) developed drug-induced lupus without major organ damage, and I developed autoimmune hemolytic anemia. Antinuclear antibodies were associated with the female sex (odds ratio, 3.166; 95% confidence interval, 1.167-8.585; P = 0.024) and with papulosquamous or butterfly rash (odds ratio, 10.016; 95% confidence interval, 1.708-58.725; P = 0.011). Conclusions: The cumulative incidence of antinuclear antibodies was 56.8% after 24 months in this cohort of infliximab-treated Crohn's disease patients. Antinuclear antibodies persisted up to I year after the last infusion, and only a few patients became seronegative. Two patients developed drug-induced lupus erythematosus. Antinuclear antibodies were associated with the female sex and skin manifestations. [less ▲]

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See detailAutoimmunity following neonatal tolerance to alloantigens: role of donor I-A and I-E molecules
Kramar, G.; Schurmans, Stéphane ULg; Berney, M. et al

in Journal of Autoimmunity (1995), 8

The injection of semi-allogeneic F1 spleen cells into newborn mice of a parental strain induces a state of immune tolerance characterized by anti-donor CTL unresponsiveness and the appearance of a ... [more ▼]

The injection of semi-allogeneic F1 spleen cells into newborn mice of a parental strain induces a state of immune tolerance characterized by anti-donor CTL unresponsiveness and the appearance of a transient SLE-like autoimmune syndrome associating autoantibody production, hypergammaglobulinemia, splenomegaly and glomerulonephritis. Our previous experiments have demonstrated that host Th2-like CD4+ T lymphocytes activate donor F1 B cells persisting in the host to produce autoantibodies, and that this cellular interaction relies on the presence of alloMHC class II molecules on donor B cells. In order to investigate the role and the involvement of MHC alloantigens in the cellular T(host)-B(donor) interaction, newborn C57BL/6 (B6) mice were injected with F1 spleen cells differing from the host at the level of defined portions of the MHC class I (K) or class II (I-A and I-E) molecules. B6 mice injected at birth with spleen cells from different F1 strains were tolerant to each alloantigen (alloAg) tested, as assessed by specific anti-donor CTL unresponsiveness. However, the SLE-like autoimmune syndrome only developed in B6 mice injected at birth with F1 spleen cells differing at the level of MHC class II I-A or I-E molecules. Autoantibodies appeared later in B6 mice neonatally tolerized to I-E alloAg than those detected in B6 mice neonatally tolerized to I-A alloAg. These results show that the SLE-like autoimmune disease that develops concomitantly to neonatally-induced tolerance to alloAg is the consequence of cognate T host-B donor cellular interactions triggered by even minute differences in the MHC class II I-A or MHC class II I-E molecules [less ▲]

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See detailAutoimmunity-related granulomatous dermatitis in association with hepatitis.
Szepetiuk, Gregory; Lesuisse, Marianne; PIERARD, Gérald ULg et al

in Case Reports in Dermatology (2012), 4(1), 80-4

AIM: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably ... [more ▼]

AIM: Both interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are rare disorders typically associated with systemic autoimmune conditions. They probably represent different aspects of a disease spectrum encompassing the concept of autoimmunity-related granulomatous dermatitis (ARGD). CASE REPORT: A 61-year-old woman presented with ARGD and autoimmune hepatitis. The clinical presentation suggested PNGD, while histopathology was consistent with IGD. DISCUSSION: The association of ARGD with autoimmune hepatitis is apparently a rare event. The present case shows that the clinicopathological correlation in ARGD does not always clearly fit with the classical presentations of IGD or PNGD. [less ▲]

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See detailAutoionization in Diatomic Molecules: an example of Electrostatic Autoionization in CO.
Raseev, G.; Leyh, Bernard ULg; Lefebvre-Brion, H.

in Zeitschrift für Physik. D, Atoms, Molecules, and Clusters (1986), 2

A review is presented of the different types of autoionization which have been studied theoretically in diatomic molecules: electronic (or electrostatic), rotational, spin-orbit and vibrational ... [more ▼]

A review is presented of the different types of autoionization which have been studied theoretically in diatomic molecules: electronic (or electrostatic), rotational, spin-orbit and vibrational autoionizations. An example involving a large number of vibrational channels is treated. It concerns the electrostatic autoionization in the 730-708 Angstöm wavelength region which appears in the CO photoionization spectrum. The structure observed at 721 Angstrôm is explained by the enhancement in intensity of numerous levels of Rydberg series converging to excited levels of the A 2Pi state caused by two autoionized Rydberg levels with a B 2Sigma+ core. [less ▲]

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See detailAutologous Blood Donation Plus Epoetin Alfa in Nonanemic Orthopedic Surgery Patients
Baudoux, Etienne ULg

in Seminars in Hematology (1996), 33(2 Suppl 2), 31-233

Intravenous (i.v.) administration of epoetin alfa facilitates the collection of autologous blood (AB) prior to elective orthopedic surgery. However, the optimum dose and dosage regimen remains to be ... [more ▼]

Intravenous (i.v.) administration of epoetin alfa facilitates the collection of autologous blood (AB) prior to elective orthopedic surgery. However, the optimum dose and dosage regimen remains to be defined. The aim of this multicenter, randomized, placebo-controlled study was to determine the optimum i.v. dose of epoetin alfa (300 IU/kg or 600 IU/kg) that would allow nonanemic patients to donate > or = 4 units of AB within 14 to 21 days of elective orthopedic surgery. All patients (n = 103) received oral iron supplementation and were treated with epoetin alfa or placebo three times during 1 week, within 3 weeks of surgery. Eighty patients were evaluable in the efficacy analysis. Compared with placebo, significantly more evaluable patients treated with epoetin alfa were able to donate > or = 4 AB units. Furthermore, epoetin alfa dose-dependently increased the preoperative reticulocyte count and attenuated the decrease in hematocrit associated with AB predonation. There was no significant difference with respect to allogeneic blood exposure between the epoetin alfa and placebo treatment groups. In addition, the 600 IU/kg dose was not significantly more effective than the 300 IU/kg dose for most efficacy parameters assessed. Several patients became iron-deficient, suggesting that oral supplementation is not an adequate source of iron in these patients. Epoetin alfa 300 IU/kg therefore appears to be the optimum i.v. dose for facilitating the collection of > or = 4 units of AB within 14 to 21 days of elective orthopedic surgery. [less ▲]

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See detailAutologous cord blood use: Clinical and scientific aspects
Angenon, Elyane; BAUDOUX, Etienne ULg; BEGUIN, Yves ULg et al

Report (2011)

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See detailAutologous stem cell transplantations in elderly AML patients
Archimbaud, E.; Jehn, U.; De Cataldo, F. et al

in Trends in Onco-Hematology (1996), 4(2), 28-29

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See detailAutomata-based Representations for the Verification of Hybrid Systems
JODOGNE, Sébastien ULg

in Proc. Summer School Modelling and Verification of Parallel Processes (MOVEP) (2002, June)

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See detailAn Automata-Based Symbolic Approach for Verifying Programs on Relaxed Memory Models
Linden, Alexander ULg; Wolper, Pierre ULg

in Lecture Notes in Computer Science (2010, September)

This paper addresses the problem of verifying programs for the relaxed memory models implemented in modern processors. Specifically, it considers the TSO (Total Store Order) relaxation, which corresponds ... [more ▼]

This paper addresses the problem of verifying programs for the relaxed memory models implemented in modern processors. Specifically, it considers the TSO (Total Store Order) relaxation, which corresponds to the use of store buffers. The proposed approach proceeds by using finite automata to symbolically represent the possible contents of the store buffers. Store, load and commit operations then correspond to operations on these finite automata. The advantage of this approach is that it operates on (potentially infinite) sets of buffer contents, rather than on individual buffer configurations. This provides a way to tame the explosion of the number of possible buffer configurations, while preserving the full generality of the analysis. It is thus possible to check even designs that exploit the relaxed memory model in unusual ways. An experimental implementation has been used to validate the feasibility of the approach. [less ▲]

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See detailAutomata-Based Symbolic Representations of Polyhedra
Boigelot, Bernard ULg; Brusten, Julien ULg; Degbomont, Jean-François ULg

in Lecture Notes in Computer Science (2012, March), 7183

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See detailAn Automata-Theoretic Approach to Automatic Program Verification
Vardi, Moshe Y; Wolper, Pierre ULg

in Proceedings of the First Symposium on Logic in Computer Science (1986)

We describe an automata-theoretic approach to the automatic verification of concurrent finite-state programs by model checking.The basic idea underlying this approach is that for any temporal formula we ... [more ▼]

We describe an automata-theoretic approach to the automatic verification of concurrent finite-state programs by model checking.The basic idea underlying this approach is that for any temporal formula we can construct an automaton that accepts precisely the computations that satisfy the formula. The model-checking algorithm that results from this approach is much simpler and cleaner than tableau-based algorithms. We use this approach to extend model checking to probabilistic concurrent finite-state programs. concurrent finite-state programs. [less ▲]

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See detailAn Automata-Theoretic Approach to Branching-Time Model Checking
Bernholtz, Orna; Vardi, Moshe Y; Wolper, Pierre ULg

in Computer Aided Verification, Proc. 6th Int. Workshop (1994)

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See detailAn automata-theoretic approach to branching-time model checking
Kupferman, Orna; Vardi, Moshe Y; Wolper, Pierre ULg

in Journal of the ACM (2000), 47(2), 312-360

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this ... [more ▼]

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this verification method. On the other hand, for branching temporal logic, automate-theoretic techniques have long been thought to introduce an exponential penalty, making them essentially useless for model-checking. Recently, Bernholtz and Grumberg [1993] have shown that this exponential penalty can be avoided, though they did not match the linear complexity of non-automata-theoretic algorithms. In this paper, we show that alternating tree automata are the key to a comprehensive automata-theoretic framework for branching temporal logics. Not only can they be used to obtain optimal decision procedures, as was shown by Muller ct al., but, as we show here, they also make it possible to derive optimal model-checking algorithms. Moreover, the simple combinatorial structure that emerges from the automata-theoretic approach opens up new possibilities for the implementation of branching-time model checking, and has enabled us to derive improved space complexity bounds for this long-standing problem. [less ▲]

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See detailAn Automata-Theoretic Approach to Presburger Arithmetic Constraints
Wolper, Pierre ULg; Boigelot, Bernard ULg

in Lecture Notes in Computer Science (1995), 983

This paper introduces a finite-automata based representation of Presburger arithmetic definable sets of integer vectors. The representation consists of concurrent automata operating on the binary ... [more ▼]

This paper introduces a finite-automata based representation of Presburger arithmetic definable sets of integer vectors. The representation consists of concurrent automata operating on the binary encodings of the elements of the represented sets. This representation has several advantages. First, being automata-based it is operational in nature and hence leads directly to algorithms, for instance all usual operations on sets of integer vectors translate naturally to operations on automata. Second, the use of concurrent automata makes it compact. Third, it is insensitive to the representation size of integers. Our representation can be used whenever arithmetic constraints are needed. To illustrate its possibilities we show that it can handle integer programming optimally, and that it leads to a new original algorithm for the satisfiability of arithmetic inequalities. [less ▲]

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See detailL'automate spirituel : pensée et cinéma chez Walter Benjamin
Barbion, Sébastien ULg

Conference (2013, April 24)

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