Atypical localisation of spinal compression caused by a sporadic lymphosarcoma in a calf
Vandeputte, Sébastien ; Brihoum, Mounir ; Guyot, Hugues et al
Poster (2006, October 16)Detailed reference viewed: 23 (9 ULg)
An atypical member of the light-harvesting complex stress-related protein family modulates diatom responses to light.
; ; et al
in Proceedings of the National Academy of Sciences of the United States of America (2010), 107(42), 18214-9
Diatoms are prominent phytoplanktonic organisms that contribute around 40% of carbon assimilation in the oceans. They grow and perform optimally in variable environments, being able to cope with ... [more ▼]
Diatoms are prominent phytoplanktonic organisms that contribute around 40% of carbon assimilation in the oceans. They grow and perform optimally in variable environments, being able to cope with unpredictable changes in the amount and quality of light. The molecular mechanisms regulating diatom light responses are, however, still obscure. Using knockdown Phaeodactylum tricornutum transgenic lines, we reveal the key function of a member of the light-harvesting complex stress-related (LHCSR) protein family, denoted LHCX1, in modulation of excess light energy dissipation. In contrast to green algae, this gene is already maximally expressed in nonstressful light conditions and encodes a protein required for efficient light responses and growth. LHCX1 also influences natural variability in photoresponse, as evidenced in ecotypes isolated from different latitudes that display different LHCX1 protein levels. We conclude, therefore, that this gene plays a pivotal role in managing light responses in diatoms. [less ▲]Detailed reference viewed: 30 (3 ULg)
Atypical metabolisms and biochemical cycles imposing the cancerous state on plant cells
Gaspar, Thomas ; ; Kevers, Claire et al
in Plant Growth Regulation (1998), 24(2), 135-144
The biological, morphological and biochemical characteristics which define plant cancer cells at the end of a neoplasic progression in the absence of pathogens and which distinguish them from tumorous ... [more ▼]
The biological, morphological and biochemical characteristics which define plant cancer cells at the end of a neoplasic progression in the absence of pathogens and which distinguish them from tumorous cells are summarized. Such plant cancer cells have in common with animal cancer cells many metabolic disturbances. The present paper reviews the biochemical changes in nitrogen, carbon, sugar and heme metabolisms which contribute to polyamine (PAs) accumulation. It indicates how these changes are interconnected and even form between each other biochemical cycles which likely maintain these cells in their irreversible state. The role of these cycles in the maintenance of such cells under a probable permanent oxidative stress is debated. [less ▲]Detailed reference viewed: 101 (6 ULg)
in In proceedings: European Equine Health & Nutrition Congress (5th edition) (2011, April 16)
Atypical myopathy is a pasture-associated syndrome characterised by the sudden onset of acute rhabdomyolysis apart from any exercise. This frequently fatal acquired condition is intimately linked with the ... [more ▼]
Atypical myopathy is a pasture-associated syndrome characterised by the sudden onset of acute rhabdomyolysis apart from any exercise. This frequently fatal acquired condition is intimately linked with the environment. Atypical myopathy occurs primarily in autumn in Europe and Midwestern United States (Finno et al. 2006) (van Galen et al. 2011a) but outbreaks have also been reported in spring (Votion et al 2003; van Galen et al. 2011a). Atypical myopathy appears to be specific to horses and to the author’s knowledge no other grazing livestock has been confirmed for the disease. In recent years, atypical myopathy has been recognized as an emergent disease (Votion and Serteyn 2008; van Galen et al. 2010). Lately, major advances have been made in the understanding of the pathophysiology of the condition (Cassart et al. 2007; van der Kolk et al. 2010) and causative hypothesis (Unger-Torroledo et al. 2010). The metabolic defect occurring in atypical myopathy affected horses is a multiple acyl-CoA dehydrogenase deficiency (MADD), which affects mitochondrial fatty acid energy metabolism but not the use of carbohydrates for energy supply (van Galen et al. 2008; Westermann et al. 2008). The development of atypical myopathy is probably multifactorial but the condition has been associated with Clostridium sordellii lethal toxin (Unger-Torroledo et al. 2010). However, no specific treatment of the condition exists and the most effective way of controlling the disease is prevention that includes specific management practices at the horse and pasture levels. This review summarises the latest knowledge about atypical myopathy and provides practical information to prevent the disease. [less ▲]Detailed reference viewed: 32 (7 ULg)
Atypical myopathy (myoglobinuria): 5 cases-based questions.
Votion, Dominique ; Serteyn, Didier
Scientific conference (2008, April)
Case-based questions ... and answers!Detailed reference viewed: 10 (0 ULg)
Atypical Myopathy In Grazing Horses: A First Exploratory Data Analysis
Votion, Dominique ; Linden, Annick ; Delguste, Catherine et al
in Veterinary Journal (2009), 180(1),Detailed reference viewed: 225 (43 ULg)
Atypical myopathy: epidemiology and aetiopathogenesis
in In proceedings: 51th British Equine Veterinary Association (BEVA) Congress (2013, September)Detailed reference viewed: 80 (9 ULg)
Atypical myopathy: new insights into the pathophysiology, prevention and management of the condition
Van Galen, Gaby ; Serteyn, Didier ; Amory, Hélène et al
in Equine Veterinary Education (2008), 20(5), 234-238Detailed reference viewed: 39 (7 ULg)
Atypical plasma cells with coexpression of myeloid markers and bundles of Auer rod-like inclusions.
KEUTGENS, Aurore ; FOGUENNE, Jacques ; Gothot, André et al
in International journal of laboratory hematology (2014)Detailed reference viewed: 18 (12 ULg)
Atypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature.
RAUW, Laetitia ; DELBECQUE, Katty ; GOFFIN, Frédéric et al
in Gynecologic oncology case reports (2013), 6
*Rare case of PSTT limited to the vagina presenting eight years after last pregnancy and four years after hysterectomy*Differential diagnosis with other vaginal tumors can be challenging but it is ... [more ▼]
*Rare case of PSTT limited to the vagina presenting eight years after last pregnancy and four years after hysterectomy*Differential diagnosis with other vaginal tumors can be challenging but it is critical because behavior and management are different.*Stage-adapted management is proposed and surgery is the mainstay treatment for localized disease. [less ▲]Detailed reference viewed: 29 (2 ULg)
Atypical recurrent varicella in 4 patients with hemopathies.
Nikkels, Arjen ; ; et al
in Journal of the American Academy of Dermatology (2003), 48(3), 442-7
Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with ... [more ▼]
Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with malignant hemopathies who had an unusual form of recurrent varicella develop. Conventional microscopy, immunohistochemistry, and in situ hybridization were applied to smears and skin biopsy specimens. The patients presented a few dozen, scattered, large, papulovesicular lesions with central crusting. No zoster-associated pain or dermatomal distribution of the lesions was noted. Conventional microscopy revealed vascular changes and epidermal alterations typical for alpha-herpes virus infection. The varicella zoster virus major viral envelope glycoproteins gE and gB, and the immediate-early varicella zoster virus IE63 protein and the corresponding genome sequence for gE were detected on Tzanck smears; they were localized in endothelial cells and keratinocytes on skin biopsy specimens. The varicella zoster virus infection in endothelial cells, the vascular involvement, and the widespread distribution of the lesions suggest that the reported eruptions are vascular rather than neural in origin. These findings invalidate the diagnosis of herpes zoster but strongly support the diagnosis of recurrent varicella in an indolent and yet unreported presentation. Furthermore, these eruptions differ from relapsing varicella in children and young adults by the age of the patients, the paucity of clinical lesions, the larger diameter of the lesions and their peculiar clinical aspect, the significantly longer time interval between primary varicella and the recurrence, the prolonged healing time of the lesions, their mild disease course, and the fact that all the lesions are in the same stage of development. [less ▲]Detailed reference viewed: 35 (0 ULg)
Atypical subunit composition of the chlorophycean mitochondrial F1FO ATP synthase and role of Asa7 protein in stability and oligomycin resistance of the enzyme.
; ; et al
in Molecular Biology and Evolution (2010), 27(7), 1630-1644
Background. In yeast, mammals, and land plants, mitochondrial F(1)F(O) ATP synthase (complex V) is a remarkable enzymatic machinery which comprises about 15 conserved subunits. Peculiar among eukaryotes ... [more ▼]
Background. In yeast, mammals, and land plants, mitochondrial F(1)F(O) ATP synthase (complex V) is a remarkable enzymatic machinery which comprises about 15 conserved subunits. Peculiar among eukaryotes, complex V from Chlamydomonadales algae (order of chlorophycean class) has an atypical subunit composition of its peripheral stator and dimerization module, with 9 subunits of unknown evolutionary origin (Asa subunits). In vitro, this enzyme exhibits an increased stability of its dimeric form, and in vivo, Chlamydomonas reinhardtii cells are insensitive to oligomycins, which are potent inhibitors of proton translocation through the F(O) moiety. Methodology/Principal Findings. In this work, we showed that the atypical features of the Chlamydomonadales complex V enzyme are shared by the other chlorophycean orders. By biochemical and in silico analyses, we detected several atypical Asa subunits in Scenedesmus obliquus (Sphaeropleales) and Chlorococcum ellipsoideum (Chlorococcales). In contrast, Complex V has a canonical subunit composition in other classes of Chlorophytes (Trebouxiophyceae, Prasinophyceae, and Ulvophyceae) as well as in Streptophytes (land plants) and in Rhodophytes (red algae). Growth, respiration and ATP levels in Chlorophyceae were also barely affected by oligomycin concentrations that affect representatives of the other classes of Chlorophytes. We finally studied the function of the Asa7 atypical subunit by using RNA interference in C. reinhardtii. Although the loss of Asa7 subunit has no impact on cell bioenergetics or mitochondrial structures, it destabilizes in vitro the enzyme dimeric form and renders growth, respiration and ATP level sensitive to oligomycins. Conclusions/Significance. Altogether, our results suggest that the loss of canonical components of the Complex V stator happened at the root of chlorophycean lineage and was accompanied by the recruitment of novel polypeptides. Such a massive modification of Complex V stator features might have conferred novel properties, including the stabilization of the enzyme dimeric form and the shielding of the proton channel. In these respects, we discuss an evolutionary scenario for F(1)F(O) ATP synthase in the whole green lineage (i.e. Chlorophyta and Streptophyta). [less ▲]Detailed reference viewed: 54 (18 ULg)
Atypical symptoms of GORD in Belgium: Epidemiological features, current management and open label treatment with 40 mg esomeprazole for one month
Louis, Edouard ; ; et al
in Acta Gastro-Enterologica Belgica (2006), 69(2, Apr-Jun), 203-208
Frequency of atypical symptoms in patients suffering from gastro-oesophageal reflux disease (GORD) is not well known, and the optimal management of such symptoms has not been well established. Our aims ... [more ▼]
Frequency of atypical symptoms in patients suffering from gastro-oesophageal reflux disease (GORD) is not well known, and the optimal management of such symptoms has not been well established. Our aims were to set up an observatory of these atypical symptoms of GORD in Belgium and to study the efficacy of one month treatment with esomeprazole 40 mg. Patients and methods : Gastroenterologists; participating in this observational survey were asked to register every new outpatient with symptoms of GORD during a period of 20 consecutive working days. All patients who reported predominant presence of atypical manifestations of GORD were documented and characterized more in detail. In patients with dominant chest pain or ENT symptoms, a treatment with esomeprazole 40 mg daily during 4 weeks was proposed. Results : 90 gastroenterologists included 2864 patients consulting for symptoms suggestive of GORD, including 776 (27.1%) with dominant atypical symptoms. Endoscopy (performed in 2800 patients) showed significantly less oesophagitis in atypical than in typical GORD patients (68% vs. 81.1%; P < 0.0001). Management of atypical GORD patients appeared to be very heterogeneous. Overall 516/776 patients were included in the open phase of treatment with esomeprazole 40 mg, but data for analysis are only available in 228 patients. After one month, symptoms had disappeared in 57.1% and significantly improved in 26.6%. Conclusion : Atypical GORD represents a large number of consultations in gastroenterology in Belgium. It is associated with less endoscopic lesions than typical GORD. Its management is heterogeneous reflecting the lack of guidelines on this topic. Response rate after esomeprazole 40 mg for one month in this open uncontrolled trial was high. This result warrants confirmation in a placebo-controlled trial. [less ▲]Detailed reference viewed: 43 (2 ULg)
Atypicality indices as reference values for laboratory data.
in American Journal of Clinical Pathology (1981), 76(4), 421-5
There have been several methods suggested for relating laboratory results to relevant reference values; none has been completely satisfactory. The method described in this paper is referring to ... [more ▼]
There have been several methods suggested for relating laboratory results to relevant reference values; none has been completely satisfactory. The method described in this paper is referring to atypicality indices for uniform reporting and feasible interpretation of laboratory data. The index associated with a measurement is defined as the probability of finding a results closer to the mean of the reference population than the one actually observed. Thus the larger the index, the less likely the measured value would be in the reference population and the more atypical it becomes. The proposed method, unlike any other, keeps the same simple and desirable features when extended to multivariate situations, that is when several tests are to be interpreted simultaneously. [less ▲]
Au carrefour de la narratologie et de la traductologie. Le narrateur comme problème de traduction
Conference (2012, March 22)Detailed reference viewed: 21 (0 ULg)