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Peer Reviewed
See detailAssessment of a bone biopsy technique for tiludronic acid dosage in horses: a preliminary study
Delguste, Catherine ULg; Doucet, Michèle; Gabriel, Annick ULg et al

Poster (2006, September)

Introduction Tiludronic acid as a bisphosphonate has a strong affinity for bone, making difficult the assessment of its PK profile in this deep compartment on living animals. The invasive nature of sample ... [more ▼]

Introduction Tiludronic acid as a bisphosphonate has a strong affinity for bone, making difficult the assessment of its PK profile in this deep compartment on living animals. The invasive nature of sample collection remains a limiting factor. This study was carried out in order to assess a bone biopsy technique allowing the repetition of sampling over a long period of time to dose tiludronic acid in equine bone. Material and Methods Six healthy 4- to 8-year-old Standardbred geldings were treated with tiludronic acid 1 mg/kg in a saline infusion over 30 minutes. The horses were subjected to euthanasia on days 1, 43, 57, 92, 182 and 222 post-treatment, respectively. Bone samples (test samples and larger reference samples) were taken at 4 sites per side and per horse: the lateral aspect of the metacarpal bone III (MCIII) of the forelimb, the 13th rib, the tuber coxae and the cuboïd bone. Test samples were taken with a 5-mm diameter dental drill (Implanteo™, Anthogyr), while larger reference samples were taken around the drill sample sites with an osteotome. All samples were taken immediately after euthanasia. Tiludronic acid concentrations were measured by HPLC with UV detection. Results The tuber coxae was the easiest site to sample. The sample site of the MCIII was easily accessible but due to the extreme hardness of the bone, the drill sampling was technically difficult to perform. Drill samples obtained from the 13th rib were very small, and the access more limited. Finally, the access to the cuboïd bone required considerable dissection, not performable in vivo. Extraction and dosage of tiludronic acid from the MCIII was difficult for technical reasons in most cases, in drill samples as well as in reference samples, and most (96%) of the values obtained were considered unreliable. This was also true for some samples from the 13th rib and from the cuboïd bone, to a lesser extent (42% of unreliable values for both sites). Moreover, for these two sample sites, less technical problems were encountered for the extraction and dosage of tiludronic acid in drill samples than in reference samples. No extraction or dosage problem was encountered with the tuber coxae samples. The ratio of tiludronic acid concentrations in drill versus reference samples ranged from 73% to 185% (mean: 124%), 65% to 208% (mean: 118%), and 26% to 110% (mean: 62%) respectively in the tuber coxae, 13th rib and cuboïd bone. In all but one horse, the highest concentrations in tiludronic acid were found in the tuber coxae, while the lowest values tended to be in the cuboïd bone at any time post-treatment. Tiludronic acid was still found in all bone samples 7 months after treatment. Discussion As previously reported with other tools, the drill tested in this study should permit to conveniently perform bone biopsies in the equine tuber coxae. This biopsy site would be the most appropriate for repeated sampling to dose tiludronic acid over time. This would help to design appropriate PK/PD studies with tiludronic acid in horses. This study also further confirms the long persistence of tiludronic acid in equine bone. [less ▲]

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See detailAssessment of a design to monitor the influence of crop residue management on the dynamics of soil water content with ERT
Chelin, Marie ULg; Hiel, Marie-Pierre ULg; Hermans, Thomas ULg et al

Poster (2016, April 21)

Choices related to crop residue management affect the soil structure. As a consequence, they may determinethe spatio-temporal dynamics of water content and eventually the crop yields. In order to better ... [more ▼]

Choices related to crop residue management affect the soil structure. As a consequence, they may determinethe spatio-temporal dynamics of water content and eventually the crop yields. In order to better understand the influence of these strategies on hydraulic processes occurring at the plot scale, we opted for the use electrical resistivity tomography (ERT). This approach presents the advantage to limit soil disturbance but is still faced to important challenges when applied in an agricultural field context. Especially changing soil-electrode contact has to be considered, as it can lead to bad quality data, especially for setups with small electrodes and small inter-electrode distance. The objective of this study was to test the efficiency of a high-resolution 3-D field measurement design to properly assess the dynamics of soil water content. ERT measurements were conducted in a Cutanic Siltic Luvisol in Gembloux, Belgium, on two plots of 2m^2 ploughed in Oct 2014 at a depth of 25 cm and sown with maize in April 2015. The plants were removed on one of the plots in order to obtain a bare soil reference. A grid of 98 surface stainless steel electrodes was layed-out on each plot and four sticks supporting each eight stainless steel electrodes were vertically inserted into the soil up to 1.20 m to get more detailed information in depth. The experiments were performed between Jul and Oct 2015, in order to get measurements both in dry and wet periods. For surface and borehole monitoring, a dipole-dipole array configuration including in-line and cross-line measurements was adopted. Normal and reciprocal measurements were performed systematically to assess the data quality: only the datasets with a mean reciprocal error lower than 3% were considered for the data inversion. This contribution will show the first inverted results showing the complexity of experimental design and data analysis for high-resolution, timelapse ERT in field conditions. Based on these results, we will draw conclusions about a minimal data set to be obtained in our upcoming field experiments. [less ▲]

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See detailAssessment of a multiscale fatigue damage model associated with stress gradient effects
Duchene, Laurent ULg; Marmi, Abdeljalil ULg; Habraken, Anne ULg

Poster (2014, September)

The aim of this research work is to develop a finite element numerical tool able to predict accurately the fatigue life of mechanical components. These components can have complex geometries, they can be ... [more ▼]

The aim of this research work is to develop a finite element numerical tool able to predict accurately the fatigue life of mechanical components. These components can have complex geometries, they can be submitted to a complex loading, leading to a specific stress field with possible stress concentration. Additionally, the successive cycles of loading are not necessarily identical. It is expected that the numerical tool can handle these demanding constraints. In this respect, a multiaxial fatigue damage model was implemented in our home-made finite element code Lagamine. The finite element method permits to account for the actual geometry of the mechanical part and the loading for the stress computation in the whole structure. The formulation of the multiaxial fatigue model is able to capture: - The non linear damage accumulation for multiblock and variable cyclic loading, - The effect of the mean (hydrostatic) stress, - The effect of the cycles below the fatigue limit if the damage was previously initiated. Finally, the occurrence of stress concentration will significantly reduce the life time of the studied piece. However, it is well-known that the subsequent local degradation of the material will be partly compensated by an enhanced load carrying contribution of the surrounding material, favourably leading to a reduction of the crack propagation. The stress gradients computed with different techniques are incorporated in the model so as to account for such beneficial influence. The physical roots of this model depart from the mesoscopic length scale, where the damage evolution is related to the mesoscopic accumulated plastic strain. Therefore, the variables of the model are defined at both macroscopic and mesoscopic scales and a specific scale transition method was implemented, based on the well-known simplified Zarka method but used at the multiscale level. The predictive capabilities of this multiscale multiaxial model are assessed by means of comparison with the classical Lemaitre-Chaboche model (implemented in the same FE code with stress gradient effects). For both models, the material parameters were identified from SN tests on smooth specimens of Ti-6Al-4V alloy, while the predictions of the models are validated thanks to comparison with experimental tests on notched samples, with stress gradient effects. [less ▲]

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See detailassessment of acid base imbalances in horses suffering from atypical myopathy
Van Galen, Gaby ULg; Cerri, Simona ULg; Porter, Sarah et al

in proceedings AAEP 2011 (2011, November 11)

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See detailAssessment of an anomaly detector for jet engine health monitoring
Borguet, Sébastien ULg; Léonard, Olivier ULg

in International Journal of Rotating Machinery (2011), 2011

The goal of module performance analysis is to reliably assess the health of the main components of an aircraft engine. A predictive maintenance strategy can leverage this information to increase ... [more ▼]

The goal of module performance analysis is to reliably assess the health of the main components of an aircraft engine. A predictive maintenance strategy can leverage this information to increase operability and safety as well as to reduce costs. Degradation undergone by an engine can be divided into gradual deterioration and accidental events. Kalman filters have proven very efficient at tracking progressive deterioration but are poor performers in the face of abrupt events. Adaptive estimation is considered as an appropriate solution to this deficiency. This paper reports the evaluation of the detection capability of an adaptive diagnosis tool on the basis of simulated scenarios that may be encountered during the operation of a commercial turbofan engine. The diagnosis tool combines a Kalman filter and a secondary system that monitors the residuals. This auxiliary component implements a generalised likelihood ratio test in order to detect abrupt events. [less ▲]

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See detailAssessment of asphalt concrete acoustic performance in urban streets
Paje, S.E.; Bueno, M.; Terán, F. et al

in Journal of acoustical society of america (2008), 123(3), 1439-1445

Geo-referenced close proximity rolling noise and sound absorption measurements are used for acoustical characterization of asphalt concrete surfaces in an urban environment. A close proximity noise map of ... [more ▼]

Geo-referenced close proximity rolling noise and sound absorption measurements are used for acoustical characterization of asphalt concrete surfaces in an urban environment. A close proximity noise map of streets with low speed limits is presented for a reference speed of 50 km/h. Different pavements and pavement conditions, common in urban streets, are analyzed: dense and semidense asphalt concrete, with Spanish denomination D-8 and S-12, respectively, and on the other hand, dense pavement at the end of its service life 􏰁D-8*􏰀. From the acoustics point of view, the most favorable surface, by more than 4 dB􏰁A􏰀 compared with the S-12 mix, is the smoothest surface, i.e., the D-8 mix, even though it presents a minor absorption coefficient in normal incidence. Noise levels from dense surfaces 􏰁D-8􏰀 increase significantly over time, principally due to the appearance of surface defects such as cracks and ruts. Longitudinal variability of the close proximity tire/ pavement noise emission and surface homogeneity are also analyzed. [less ▲]

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See detailAssessment of bacterial persistence in mosquitoes according to microinjection assays in Belgium
Raharimalala, Fara Nantenaina ULg; Bawin, Thomas ULg; Boukraa, Slimane ULg et al

Poster (2013, October 02)

The problems caused by the massive used of pesticides have resulted in the establishment of resistant vectors besides the destruction of the environment. Furthermore, climate change has consequently ... [more ▼]

The problems caused by the massive used of pesticides have resulted in the establishment of resistant vectors besides the destruction of the environment. Furthermore, climate change has consequently modified the comportment of disease vectors. Current research tends to look for alternative means to overcome the problem. The goal of that study was to undertaken the way there this objective. By their presence or absence, endosymbiotic microorganisms can influence vector competence and vectorial capacity. Our research aims to study the effect of the introduction of endosymbiotic bacteria in the mosquito species that could be potential vectors of disease in Belgium. Method used was the microinjection of endosymbiotic bacteria within the detected exempt mosquito species. Three genus of suspected vectors belonging to Aedes, Anopheles and Culex were microinjected at different stages of their life cycle (eggs, larvae, pupae, and adults), and survivability of mosquitoes and persistence of microorganism were determined. Results show that survival in the different stages was variable. Furthermore, persistence of endobacteria was different depending genus and stages studied [less ▲]

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Peer Reviewed
See detailAssessment of benefits of joint use of multiple medical imaging modalities: case of 3D neuroimaging
Vigneron, Lara M.; Verly, Jacques ULg

Conference (2002, June)

Detailed reference viewed: 5 (0 ULg)
See detailAssessment of bioinformatic pipelines for the analysis of 454 pyrosequencing data using artificial cyanobacterial communities
Stelmach Pessi, Igor ULg; de Carvalho Maalouf, Pedro; Laughinghouse IV, Haywood Dail et al

Poster (2013, November)

Detailed reference viewed: 178 (15 ULg)
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See detailAssessment of bovine tuberculosis risk factors based on nationwide molecular epidemiology
Humblet, Marie-France ULg; Gilbert, M.; Govaerts, M. et al

in Journal of Clinical Microbiology (2010)

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See detailAssessment of cardiovascular risk of new drugs for the treatment of diabetes mellitus: risk assessment vs. risk aversion.
Zannad, Faiez; Stough, Wendy Gattis; Lipicky, Raymond J. et al

in European heart journal. Cardiovascular pharmacotherapy (2016), 2(3), 200-205

The Food and Drug Administration issued guidance for evaluating the cardiovascular risk of new diabetes mellitus drugs in 2008. Accumulating evidence from several completed trials conducted within this ... [more ▼]

The Food and Drug Administration issued guidance for evaluating the cardiovascular risk of new diabetes mellitus drugs in 2008. Accumulating evidence from several completed trials conducted within this framework raises questions as to whether requiring safety outcome studies for all new diabetes mellitus therapies remains justified. Given the burden of cardiovascular disease in patients with diabetes, the focus should shift towards cardiovascular outcome studies designed to evaluate efficacy (i.e. to determine the efficacy of a drug over placebo or standard care) rather than demonstrating that risk is not increased by a pre-specified safety margin. All stakeholders are responsible for ensuring that new drug approvals occur under conditions of appropriate safety and effectiveness. It is also a shared responsibility to avoid unnecessary hurdles that may compromise access to useful drugs and threaten the sustainability of health systems. It is critical to renew this debate so that stakeholders can collectively determine the optimal approach for developing new drugs to treat type 2 diabetes mellitus. [less ▲]

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See detailAssessment of catalysis by arene-ruthenium complexes
Le Gendre, Pierre; Borguet, Yannick; Nicks, François et al

in European Journal of Inorganic Chemistry (2015)

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See detailAssessment of changes in soil organic matter after invasion by exotic plant species
Koutika, Lydie*-Stella; Vanderhoeven, SONIA ULg; Chapuis-Lardy, Lydie et al

in Biology & Fertility of Soils (2007), 44(2), 331-341

Invasive exotic plants can modify soil organic matter (SOM) dynamics and other soil properties. We evaluated changes in particulate organic matter (POM) and carbon (C) mineralisation in adjacent plots ... [more ▼]

Invasive exotic plants can modify soil organic matter (SOM) dynamics and other soil properties. We evaluated changes in particulate organic matter (POM) and carbon (C) mineralisation in adjacent plots invaded by Solidago gigantea, Prunus serotina, Heracleum mantegazzianum and Fallopia japonica, and non-invaded control plots on different soils in Belgium. Litter decomposition of S. gigantea and P. serotina was compared to that of the native species Epilobium hirsutum, Betula pendula and Fagus sylvatica. Disregarding the differences in site characteristics (soil texture, parental material and plant species), we argued that the invasion by S. gigantea and P. serotina enhance SOM dynamics by increasing C mineralisation in 2 out of 3 sites invaded by S. gigantea and in 1 out of 3 sites invaded by P. serotina; C in coarse POM (cPOM, 4,000-250 mu m) and fine POM (fPOM, 250-50 mu m) in 1 site invaded by S. gigantea and C content in total POM (tPOM, 4,000-50 mu m) and the organo-mineral fraction (OMF, 0-50 mu m) in 1 site invaded by P. serotina. H. mantegazzianum and F. japonica slowed down SOM dynamics by reducing C mineralisation in three out of four sites; C and nitrogen (N) of fPOM in the invaded compared with the non-invaded plots at one site invaded by H. mantegazzianum. However, N content of cPOM (4,000-250 mu m) was higher in the invaded sites by F. japonica compared with the non-invaded plots. Our results indicated that the effects of invasion by exotic plant species were not species-specific but site-specific. [less ▲]

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See detailAssessment of climate change effects on groundwater resource in transient conditions
Goderniaux, Pascal; Wildemeersch, Samuel; Brouyère, Serge ULg et al

Conference (2015, June 27)

A sophisticated transient weather generator (WG) in combination with an integrated surface-subsurface hydrological model (HydroGeoSphere) are used for producing a stochastic generation of large numbers of ... [more ▼]

A sophisticated transient weather generator (WG) in combination with an integrated surface-subsurface hydrological model (HydroGeoSphere) are used for producing a stochastic generation of large numbers of equiprobable climatic time series, representing transient climate change, and assess impacts on groundwater resources in a probabilistic way. The modelling approach, involving the catchment-scale fully integrated surface-subsurface model, is described in Goderniaux et al. [2009]. Biased-corrected climate change scenarios are applied as input of the hydrological model to quantify their impact on groundwater resources. In Goderniaux et al. [2011], the integrated model is used in combination with a stochastic daily weather generator (WG). This WG allowed generating a large number of equiprobable climate change scenarios representative of a full transient climate between 2010 and 2085. These scenarios enabled to account for the transient nature of the future climate change, and to assess the uncertainty related to the weather natural variability. The downscaling method considers changes in the climatic means, but also in the distribution of wet and dry days. This new methodology is applied for the unconfined chalky aquifer of the Geer catchment in Belgium. A general decrease of the mean groundwater piezometric heads, has been calculated. The approach allowed also to assess different uncertainty sources: (1) the uncertainty linked to the calibration of the hydrological model, using 'UCODE_2005'; (2) the uncertainty linked to the global and regional climatic models (GCMs and RCMs), by using a multi-model ensemble; (3) the uncertainty linked to the natural variability of the weather, by using stochastic climate change scenarios. 30 equiprobable climate change scenarios from 2010 to 2085 have been generated for each of 6 different RCMs. Results show that although the 95% confidence intervals calculated around projected groundwater levels remain large, the climate change signal becomes stronger than that of natural climate variability by 2085. The WG ability to simulate transient climate change enabled the assessment of the likely timescale and associated uncertainty of a specific impact. This methodology constitutes a real improvement in the field of groundwater projections under transient climate change conditions as it enables water managers to analyse risks and take decisions with full knowledge of projected impact and their degree of confidence. [less ▲]

Detailed reference viewed: 77 (1 ULg)