Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
See detailAvis n° 24 du 13 octobre 2003 relatif aux cellules souches humaines et au clonage thérapeutique
Pennings, G.; Michel, L.; Vermeersch, E. et al

Report (2003)

Detailed reference viewed: 4 (0 ULg)
See detailAvis n°44 du 23 juin 2008 relatif à l'inhibition de la croissance d'enfants très sévèrement handicapés mentalement
Hiele, M.; Genicot, G.; Mortier, F. et al

Report (2008)

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailAvis sur le projet de décret spécial n° 247 (2010-2011) du 15 octobre 2010 "limitant le cumul de mandats dans le chef des députés du Parlement wallon"
Behrendt, Christian ULg

Report (2010)

Il s'agit d'une expertise réalisée à la demande du Parlement wallon sur la compatibilité avec la Constitution, la loi spéciale de réformes institutionnelles et le droit international conventionnel du ... [more ▼]

Il s'agit d'une expertise réalisée à la demande du Parlement wallon sur la compatibilité avec la Constitution, la loi spéciale de réformes institutionnelles et le droit international conventionnel du projet de décret spécial n° 247 (2010-2011) du 15 octobre 2010 « limitant le cumul de mandats dans le chef des députés du Parlement wallon ». Ledit projet a ensuite été adopté et est devenu le décret spécial du 9 décembre 2010 (Moniteur belge, 22 décembre 2010, édition 2). Il fait actuellement l'objet d'un recours en annulation devant la Cour constitutionnelle, portant les numéros de rôle 5160 et 5161. [less ▲]

Detailed reference viewed: 94 (5 ULg)
Full Text
Peer Reviewed
See detailAvocado/Soybean Unsaponifiable (Asu) to Treat Osteoarthritis: A Clarification
Henrotin, Yves ULg

in Osteoarthritis and Cartilage (2008)

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailAvocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes
Henrotin, Yves ULg; Sanchez, Christelle ULg; Deberg, Michelle ULg et al

in Journal of Rheumatology (2003), 30(8), 1825-1834

OBJECTIVE: To investigate the effects of avocado (A)/soybean (S) unsaponifiables on the metabolism of human osteoarthritic (OA) chondrocytes cultured in alginate beads over 12 days. METHODS: Enzymatically ... [more ▼]

OBJECTIVE: To investigate the effects of avocado (A)/soybean (S) unsaponifiables on the metabolism of human osteoarthritic (OA) chondrocytes cultured in alginate beads over 12 days. METHODS: Enzymatically isolated OA chondrocytes were cultured in alginate beads in a well defined culture medium for 12 days, in the presence or not of 10-10 M interleukin 1beta (IL-1beta). DNA content was measured using a fluorometric method. Production of aggrecan (AGG), stromelysin-1 (MMP-3), tissue inhibitor of metalloproteinases-1 (TIMP-1), macrophage inflammatory protein-1beta (MIP-1beta), IL-6, and IL-8 were assayed by specific enzyme amplified sensitivity immunoassays. Prostaglandin (PG) E2 was measured by a specific radioimmunoassay and nitrite by a spectrophotometric method based on the Griess reaction. A commercial avocado and soybean mixture of unsaponifiables (A1S2) and each component separately were tested in a range of 0.625 to 40.0 micro g/ml. RESULTS: After 12 days' incubation, A1S2 increased AGG synthesis and accumulation in alginate beads in a dose and time dependent manner. A1S2 promoted the recovery of aggrecan synthesis after 3 days of IL-1beta treatment. A1S2 was a potent inhibitor of basal and IL-1beta stimulated MMP-3 production. The procedure also weakly reversed the inhibitory effect of IL-1beta on TIMP-1 production. A1S2 inhibited basal production of MIP-1beta, IL-6, IL-8, NO*, and PGE2 by OA chondrocytes and partially counteracted the stimulating effect of IL-1 on PGE2. Compared to avocado or soybean added separately, the mixture had a superior effect on NO* and IL-8 production. CONCLUSION: A1S2 stimulated aggrecan production and restored aggrecan production after IL-1beta treatment. In parallel, A1S2 decreased MMP-3 production and stimulated TIMP-1 production. These results suggest A1S2 could have structure-modifying effects in OA by inhibiting cartilage degradation and promoting cartilage repair. [less ▲]

Detailed reference viewed: 73 (16 ULg)
Full Text
Peer Reviewed
See detailAvocado/soybean unsaponifiables prevent osteoarthritic subchondral osteoblasts-induced cartilage degradation
Sanchez, Christelle ULg; Deberg, Michelle ULg; Piccardi, Nathalie et al

in Osteoporosis International (2005), 16(Suppl.3), 56

Detailed reference viewed: 25 (9 ULg)
Full Text
Peer Reviewed
See detailAvocado/soybean unsaponifiables prevent the inhibitory effect of osteoarthritic subchondral osteoblasts on aggrecan and type II collagen synthesis by chondrocytes
Henrotin, Yves ULg; Deberg, Michelle ULg; Crielaard, Jean-Michel ULg et al

in Journal of Rheumatology (2006), 33(8), 1668-1678

Objective. To determine the effects of avocado/soybean unsaponifiables (ASU) on osteoblast-induced dysregulation of chondrocyte metabolism. Methods. Human chondrocytes were isolated from osteoarthritis ... [more ▼]

Objective. To determine the effects of avocado/soybean unsaponifiables (ASU) on osteoblast-induced dysregulation of chondrocyte metabolism. Methods. Human chondrocytes were isolated from osteoarthritis (OA) cartilage and cultured in alginate beads for 4 or 10 days in the absence or presence of osteoblasts isolated from nonsclerotic (NSC) or sclerotic (SC) zones of OA subchondral bone plate in monolayer. Before co-culture, osteoblasts were incubated or not with 10 mu g/ml ASU for 72 hours. Aggrecan, type 11 collagen, matrix metalloproteinase-3 (MMP-3) and MMP-13, tissue inhibitor of metalloproteinase (TIMP-1), transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 3, inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2) mRNA levels in chondrocytes were quantified by RT-PCR. Aggrecan, osteocalcin, TGF-beta 1, interleukin 18 (IL-1 beta), and IL-6 production were assayed by inummoassays. Results. In co-culture, SC osteoblasts induced a significant inhibition of matrix protein production and a significant increase of MMP synthesis by chondrocytes. In contrast, SC osteoblasts did not modify TIMP-1, TGF-beta 1 and TGF-beta 3, iNOS, or COX-2 mRNA levels in chondrocytes. The pretreatment of SC osteoblasts with ASU fully prevented the inhibitory effects of SC osteoblasts on matrix component production, and even significantly increased type 11 collagen mRNA level over the control (chondrocytes alone) value. In contrast, pretreatment of SC osteoblasts with ASU did not significantly modify the expression of NIMP, TIMP-1, TGF-beta 1, TGF-beta 3, iNOS, or COX-2 gene by chondrocytes. Conclusion. ASU prevent the osteoarthritic osteoblast-induced inhibition of matrix molecule production, suggesting that this compound may promote OA cartilage repair by acting on subchondral bone osteoblasts. This finding constitutes a new mechanism of action for this compound, known for its beneficial effects on cartilage. [less ▲]

Detailed reference viewed: 69 (12 ULg)
Full Text
Peer Reviewed
See detailAvocado/soybean unsaponifiables reverse H2O2 decoupling effect on aggrecan, type II collagen and metalloproteases gene expression in human chondrocytes
Mathy, Marianne ULg; Devel, P.; Piccardi, Nathalie et al

in Osteoarthritis and Cartilage (2003, October), 11(Suppl.1), 99

Detailed reference viewed: 11 (2 ULg)
Peer Reviewed
See detailAvocat et assureur protection juridique : la fin des tensions ?
Paris, Catherine ULg

in Revue Générale des Assurances et des Responsabilités (2000)

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailL’Avocat général Colomer estime que le refus partiel de livrer opposé par un laboratoire à des grossistes en vue d’assécher le commerce parallèle n’est pas un abus per se, mais l’intention manifestement anticoncurrentielle crée une forte présomption d’abus
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2008), 2

Conclusions de l’avocat général D. Ruiz-Jarabo Colomer, 1er avril 2008, Lélos e.a./Glaxosmithkline, C468/06 à C478/06 L’Avocat général Colomer estime que le refus partiel de livrer opposé par un ... [more ▼]

Conclusions de l’avocat général D. Ruiz-Jarabo Colomer, 1er avril 2008, Lélos e.a./Glaxosmithkline, C468/06 à C478/06 L’Avocat général Colomer estime que le refus partiel de livrer opposé par un laboratoire à des grossistes en vue d’assécher le commerce parallèle n’est pas un abus per se, mais l’intention manifestement anticoncurrentielle crée une forte présomption d’abus [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailL’avocat général Kokott est d’avis que, pour les abus consistant en une discrimination entre partenaires commerciaux, il doit être établi que la pratique de l’entreprise en position dominante crée un désavantage dans la concurrence pour l’un au moins des partenaires.
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2011), 3-2011

Conclusion AG Kokott, 12 avril 2011, Solvay c/ Commission, aff. C-109/10P L’avocat général Kokott est d’avis que, pour les abus consistant en une discrimination entre partenaires commerciaux, il doit être ... [more ▼]

Conclusion AG Kokott, 12 avril 2011, Solvay c/ Commission, aff. C-109/10P L’avocat général Kokott est d’avis que, pour les abus consistant en une discrimination entre partenaires commerciaux, il doit être établi que la pratique de l’entreprise en position dominante crée un désavantage dans la concurrence pour l’un au moins des partenaires. [less ▲]

Detailed reference viewed: 15 (1 ULg)