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See detailBasic nail surgery
Richert, Bertrand ULg

in Dermatologic Clinics (2006), 24(3), 313-322

Patients often fear nail surgery because of the pain associated with anesthesia and postoperative care. Potential dystrophic sequelae are of concern to the practitioner. A thorough knowledge of the ... [more ▼]

Patients often fear nail surgery because of the pain associated with anesthesia and postoperative care. Potential dystrophic sequelae are of concern to the practitioner. A thorough knowledge of the techniques of anesthesia, nail anatomy, and surgical procedures is a prerequisite for successful nail surgery with almost no pain and minimal scarring. It also is mandatory to involve a dermatopathologist who is familiar with the histologic idiosyncrasies of the nail unit. [less ▲]

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See detailThe basic pattern of activation in motor and sensory temporal tasks: positron emission tomography data
Lejeune, Helga ULg; Maquet, Pierre ULg; Bonnet, Michel et al

in Neuroscience Letters (1997), 235(1-2), 21-24

Positron emission tomography (PET) data were obtained from subjects performing a synchronization task (target duration 2700 ms). A conjunction analysis was run to identify areas prominently activated both ... [more ▼]

Positron emission tomography (PET) data were obtained from subjects performing a synchronization task (target duration 2700 ms). A conjunction analysis was run to identify areas prominently activated both in this task and in a temporal generalization task (target duration 700 ms) used previously. The common pattern of activation included the right prefrontal, inferior parietal and anterior cingulate cortex, the left putamen and the left cerebellar hemisphere. These areas are assumed to play a major role in time processing, in relation to attention and memory mechanisms. [less ▲]

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See detailBasic perinatal care
Battisti, Oreste ULg

Learning material (2011)

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See detailBasic Principles of White Dwarf Asteroseismology
Fontaine, Gilles; Brassard, Pierre; Charpinet, Stéphane et al

in Napiwotzki, R.; Burleigh, M. (Eds.) The White Dwarfs Stars (in press)

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See detailThe Basic Property of Lys385 Is Important for Potentiation of the Human alpha1 Glycine Receptor by Ethanol.
Castro, Patricio A; Figueroa, Maximiliano ULg; Yevenes, Gonzalo E et al

in Journal of Pharmacology and Experimental Therapeutics (2012), 340(2), 339-49

Ethanol alters the function of several members of the Cys-loop ligand-gated ion channel superfamily. Recent studies have shown that the sensitivity of the alpha1 glycine receptor (GlyR) to ethanol can be ... [more ▼]

Ethanol alters the function of several members of the Cys-loop ligand-gated ion channel superfamily. Recent studies have shown that the sensitivity of the alpha1 glycine receptor (GlyR) to ethanol can be affected by the state of G protein activation mediated by the interaction of Gbetagamma with intracellular amino acids in the GlyR. Here, we evaluated the physicochemical property of Lys385 that contributes to ethanol modulation by using mutagenesis, patch-clamp, and biochemical techniques. A conserved substitution (K385R) did not affect either the apparent glycine EC(50) (40 +/- 1 versus 41 +/- 0.5 muM) or the ethanol-induced potentiation (53 +/- 5 versus 46 +/- 5%) of the human alpha1 GlyR. On the other hand, replacement of this residue with glutamic acid (K385E), an acidic amino acid, reduced the potentiation of the GlyR to 10 +/- 1%. Furthermore, mutations with a hydrophobic leucine (K385L), a hydrogen bond donor glutamine (K385Q), or a neutral residue (K385A) also reduced ethanol modulation. Finally, substitution by a large and hydrophobic residue (K385F) and deletion of 385 (Lys385_) reduced ethanol modulation to 10 +/- 4 and 17 +/- 0.4%, respectively. Experiments using dynamic cysteine substitution with a methanethiosulfonate reagent and homology modeling indicate that the basic property and the position of Lys385, probably because of its interaction with Gbetagamma, is critical for ethanol potentiation of the receptor. [less ▲]

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See detailBasic Research and Policy Making for the Development of Vessel Traffic Management Information Systems
Marchal, Jean ULg

in Basic Research and Policy Making (1995)

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See detailBasic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2.
Mounier, C. M.; Luchetta, P.; Lecut, Christelle ULg et al

in European Journal of Biochemistry (2000), 267(16), 4960-9

Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q ... [more ▼]

Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q mutant prolong the lag time of thrombin generation in human platelet-rich plasma with similar efficiency, indicating that hGIIA exerts an anticoagulant effect independently of phospholipid hydrolysis under ex vivo conditions. Charge reversal of basic residues on the interfacial binding surface (IBS) of hGIIA leads to decreased ability to inhibit prothrombinase activity, which correlates with a reduced affinity for factor Xa, as determined by surface plasmon resonance. Mutation of other surface-exposed basic residues, hydrophobic residues on the IBS, and His48, does not affect the ability of hGIIA to inhibit prothrombinase activity and bind to factor Xa. Other basic, but not neutral or acidic, mammalian secreted phospholipases A2 (sPLA2s) exert a phospholipid-independent inhibitory effect on prothrombinase activity, suggesting that these basic sPLA2s also bind to factor Xa. In conclusion, this study demonstrates that the anticoagulant effect of hGIIA is independent of phospholipid hydrolysis and is based on its interaction with factor Xa, leading to prothrombinase inhibition, even under ex vivo conditions. This study also shows that such an interaction involves basic residues located on the IBS of hGIIA, and suggests that other basic mammalian sPLA2s may also inhibit blood coagulation by a similar mechanism to that described for hGIIA. [less ▲]

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See detailBasic rules of dosimetry in endovascular brachytherapy.
Coucke, Philippe ULg; PHUOC DO, Hu; Pica, Alessia et al

in Journal of Interventional Cardiology (2000), 13(6), 425-429

Endovascular brachytherapy after percutaneous coronary intervention (PCI), is becoming a standard approach for the treatment and prevention of restenosis. A variety of technical approaches are currently ... [more ▼]

Endovascular brachytherapy after percutaneous coronary intervention (PCI), is becoming a standard approach for the treatment and prevention of restenosis. A variety of technical approaches are currently available to deliver ionizing irradiation to the vascular target. Basically two kinds of radioactive isotopes are available that emit gamma radiation (photons) or beta radiation (electrons). The pitfalls and solutions for the optimization of dosimetry are discussed. As might be expected, the inhomogeneous dose distribution across the target volume results in recurrence by underdosage or in complications because of overdosage. Moreover, uniformization of the target definition and reporting of the dose distribution in endovascular brachytherapy is a prerequisite for comparison between the results of the various clinical trials and is absolutely necessary to improve the therapeutic efficacy of this new approach in the prevention of restenosis after coronary angioplasty with or without stenting. (J Interven Cardiol2000; 13:425430) [less ▲]

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See detailA Basic Summary of Image Formats
Merciadri, Luca ULg

E-print/Working paper (2009)

We summarize here the most used image formats, and their respective principal applications.

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See detailBasic use and programming in the R language
Magis, David ULg

Scientific conference (2011, August 22)

R is an open-source statistical software and of increasing interest for the scientific community. It can be installed on all usual platforms (Windows, Linux, Mac) and is suitable for many statistical ... [more ▼]

R is an open-source statistical software and of increasing interest for the scientific community. It can be installed on all usual platforms (Windows, Linux, Mac) and is suitable for many statistical analyzes, graphical representation, intensive computation and programming, among others. New functionalities and packages are developed regularly and the R web community ensures a constant development and increasing usefulness of R, not only for pure statisticians but also for practitioners from various fields (psychology, education, biometrics, econometrics, etc.). Its main drawback, however, is that it requires preliminary training and practice to handle the various aspects of the software and to become efficient in using R. The purpose of this workshop is to present the basic aspects of R, from the installation to the basic statistical analysis. The following themes will be developed: installation, importing data, R objects and structures, basic computations, graphics, packages and libraries, programming in R, basic statistical modeling and testing. The workshop will be practice-oriented, with sessions mixing both “theoretical” presentations and practical applications. Live demonstrations of R will also be performed. Participants are invited to bring their laptop and to take part to the practical exercises. Slides, R scripts and illustrative data sets will be provided. [less ▲]

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See detailBasics of PEMFC including the use of carbon-supported nanoparticles
Chatenet, Marian; Job, Nathalie ULg; Maillard, Frédéric

in Suib, Steven (Ed.) New and future developments in catalysis. Catalysis by nanoparticles. (2013)

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See detailLe "basileion", les reines et Actium
Veymiers, Richard ULg

Scientific conference (2012, December 07)

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See detailLe "basileion", les reines et Actium
Veymiers, Richard ULg

in Bricault, Laurent; Versluys, Miguel John (Eds.) Power, Politics and the Cults of Isis. Proceedings of the Vth International Conference of Isis Studies, Boulogne-sur-Mer, October 13-15 2011 (in press)

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See detailLe basileion, les reines et Actium
Veymiers, Richard ULg

Scientific conference (2011, October 15)

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See detailBasin and river profile morphometry: A new index with a high potential for relative dating of tectonic uplift
Demoulin, Alain ULg

in Geomorphology (2011), 126

Geomorphometry may be a powerful tool to describe the characteristics of the landscape's response to tectonic signals, but the meaning of morphometric indices is often obscured by the interplay between ... [more ▼]

Geomorphometry may be a powerful tool to describe the characteristics of the landscape's response to tectonic signals, but the meaning of morphometric indices is often obscured by the interplay between the many variables controlling the geomorphological evolution. Moreover, although the so-called hypsometric integral refers to the basin scale, most indices are generally derived from the river long profiles and thus focus mainly on the short-term response of a drainage network to base level change, providing limited information in regions of older and/or moderate uplift. Here, using the Rhenish shield (western Europe), an area of moderate Quaternary uplift, as a test case, I attempt to build an index yielding a comprehensive view of the stage attained by the landscape's response and, indirectly, an evaluation of the timing of the triggering base level change. This index, called R1, is a ratio of differences between the three integrals linked respectively to the classical basin's hypsometric curve, to the main river's long profile, and at the intermediate level, to a ‘drainage network's hypsometric curve’. While its ratio form minimizes the lithological effect on R1, this index is strongly correlated with basin size (regional correlation coefficients are in the range 0.88–0.93), reflecting the way an erosion wave propagates from the outlet of a basin toward its headwaters. Therefore, it is not directly usable as a proxy for relative uplift age. However, one can show that the relation between R1 and basin size is theoretically expected to change with time. Following uplift, the slope Sr of the linear relation R1=f (lnA) first increases rapidly but briefly, then it gradually diminishes over several million years. This is fully confirmed by the analysis of R1 and Sr in the study area. Once its initial increase is completed (assumedly in a few ten thousand years), Sr appears to be a reliable indicator of relative uplift (or any other cause of base level lowering) age. [less ▲]

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See detailBASL guidelines for the surveillance, diagnosis and treatment of hepatocellular carcinoma
Van Vlierberghe, Hans; Borbath, Ivan; Delwaide, Jean ULg et al

in Acta Gastro-Enterologica Belgica (2004), 67(1), 14-25

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See detailBasophil releasability in patients with hymenoptera venom allergy.
Radermecker, Maurice ULg; Leclercq, Maryse ULg; Mariz, S. D. et al

in International Archives of Allergy & Immunology (1993), 101(3), 283-7

Basophils in about 15% of subjects allergic to hymenoptera venom do not release histamine in the presence of antigen. Little is known on the basophil releasability in these patients. We therefore measured ... [more ▼]

Basophils in about 15% of subjects allergic to hymenoptera venom do not release histamine in the presence of antigen. Little is known on the basophil releasability in these patients. We therefore measured maximum percent leukocyte histamine release to antigen (Vespula venom), anti-IgE and formylmethionylphenylalanine (FMP) in 39 patients allergic to wasp venom and compared our results according to basophil responsiveness to antigen. Mean maximum percent histamine release was 39, 34 and 22%, respectively, for venom (100 ng/ml), anti-IgE (0.25 microgram/ml) and FMP (10(-4) M). The amount of histamine specifically released by venom correlated significantly with anti-IgE but not with FMP-induced histamine release. Leukocytes were unresponsive to antigen in 10 subjects. The clinical characteristics and anaphylactic symptoms of these patients were not different from those with antigen-responsive cells. Unresponsive leukocytes responded to FMP in all and to anti-IgE in 8 of the 10 subjects. Mean anti-IgE and FMP-induced histamine release were, respectively, lower and higher than those observed with leukocytes responsive to antigen (p < 0.05). In unresponsive basophils, there was a negative correlation between maximum percent anti-IgE and FMP-induced histamine release. We confirm that basophils of a minority of the subjects allergic to Vespula venom do not release histamine in the presence of antigen. The negative correlation between anti-IgE and FMP-induced histamine release in unresponsive basophils may suggest individual differences in the ratio of Fc epsilon RI and FMP receptors on the surface of basophils. [less ▲]

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