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See detailBaseline health-related quality-of-life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer
Efficace, F.; Biganzoli, L.; Piccart, M. et al

in European Journal of Cancer (2004), 40(7), 1021-1030

The potential value of baseline health-related quality-of-life (HRQOL) and clinical factors in predicting prognosis was examined using data from an international randomised phase III trial which compared ... [more ▼]

The potential value of baseline health-related quality-of-life (HRQOL) and clinical factors in predicting prognosis was examined using data from an international randomised phase III trial which compared doxorubicin and paclitaxel with doxorubicin and cylophosphamide as first line chemotherapy in 275 women with metastatic breast cancer. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the related breast module (QLQ-BR23) were used to assess baseline HRQOL data. The Cox proportional-hazards regression model was used for both univariate and multivariate analyses of survival. In the univariate analyses, performance status (P < 0.001) and number of sites involved (P = 0.001) were the most important clinical prognostic factors. The HRQOL variables at baseline most strongly associated with longer survival were better appetite, physical and role functioning, as well as less fatigue (P < 0.001). The final multivariate model retained performance status (P < 0.001) and appetite loss (P = 0.005) as the variables best predicting survival. Substantial loss of appetite was the only independent HRQOL factor predicting poor survival and was strongly correlated (\r\ > 0.5) with fatigue, role and physical functioning. In addition to known clinical factors, appetite loss appears to be a significant prognostic factor for survival in women with metastatic breast cancer. However, the mechanism underlying this association remains to be precisely defined in future studies. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailBaseline inflammation is not predictive of periprocedural troponin elevation after elective percutaneous coronary intervention.
Gach, Olivier ULg; Louis, Olivier ULg; Chapelle, Jean-Paul ULg et al

in Heart & Vessels (2009), 24(4), 267-70

High-sensitivity C-reactive protein predicts future cardiovascular events in both healthy individuals and patients with unstable and stable coronary syndromes. Few data are available about the incidence ... [more ▼]

High-sensitivity C-reactive protein predicts future cardiovascular events in both healthy individuals and patients with unstable and stable coronary syndromes. Few data are available about the incidence and the relation to inflammation of troponin elevation following percutaneous coronary intervention (PCI), a potential predictor of longterm outcome. We sought to confirm the impact of embolization on long-term outcome and evaluate the ability of baseline inflammation to predict troponin elevation induced by PCI. We prospectively analyzed 200 patients treated by PCI for stable or Braunwald IIA class unstable angina. The patients were recruited between January 1997 and May 1999, and the population was followed during a mean follow-up of 32 months. Major adverse cardiac events (MACEs) were defined as the occurrence of death, myocardial infarction or recurrent angina requiring repeat PCI, or coronary artery bypass grafting. During the follow-up period, 58 MACEs were observed. By multivariate analysis, independent predictors for the occurrence of MACEs were unstable angina and troponin I level after PCI (P < 0.0001 for both). No correlation was found between baseline inflammation and significant troponin I elevation post PCI and by multivariate analysis, no biological variable was a predictor of troponin I elevation post PCI. Baseline inflammation cannot predict onset of minor myonecrosis damage (expressed by troponin elevation) induced by PCI, a significant predictor of long-term outcome in this setting. [less ▲]

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See detailBaseline measurement of urine pyridinoline and deoxypyridinoline is correlated with 3-year hip osteoarthritis progression
Bruyère, Olivier ULg; COLLETTE, Julien ULg; Lejeune, Eric ULg et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 149

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See detailBaseline study of perfluorochemicals in harbour porpoises (Phocoena phocoena) from Northern Europe
Van de Vijver, Kristin Inneke; Hoff, P. T.; Das, Krishna ULg et al

in Marine Pollution Bulletin (2004), 48(9-10), 992-997

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See detailBasement Membrane Components (Matrigel) Promote the Tumorigenicity of Human Breast Adenocarcinoma Mcf7 Cells and Provide an in Vivo Model to Assess the Responsiveness of Cells to Estrogen
Noël, Agnès ULg; Simon, N.; Raus, J. et al

in Biochemical Pharmacology (1992), 43(6), 1263-7

The ability to transplant human tumors into athymic nude mice allows studies of tumor cells in vivo. However, after s.c. injection the incidence of tumor and metastases in nude mice is frequently low. We ... [more ▼]

The ability to transplant human tumors into athymic nude mice allows studies of tumor cells in vivo. However, after s.c. injection the incidence of tumor and metastases in nude mice is frequently low. We have studied the tumorigenicity in nude mice of estradiol (E2)-sensitive breast adenocarcinoma MCF7 cells. Matrigel, an extract of basement membrane proteins, induces rapid tumor development after s.c. injection of MCF7 cells. In the absence of this matrice, MCF7 cells failed to induce tumor growth. In this in vivo model, MCF7 cells were analysed for their E2 sensitivity. Two weeks after inoculation in the presence of matrigel, cells formed growing tumors in intact mice supplemented with E2. In ovariectomized or untreated mice, tumor appearance was delayed and the growth level was very low. Thus, MCF7 cells formed tumors in the absence of E2 but retained in vivo their responsiveness to estrogen. Growing human tumors in nude mice provides a rapid and useful model for testing the sensitivity of cells to hormone. [less ▲]

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See detailBasement membrane components and galactosylhydroxylysyl glucosyltransferase in suction blisters of human skin.
Oikarinen, A.; Savolainen, E. R.; Tryggvason, K. et al

in British Journal of Dermatology (1982), 106(3), 257-66

Basement membrane components and collagen biosynthesis were studied in suction blisters in human skin. The basement membrane components were characterized by immunofluorescence using specific antibodies ... [more ▼]

Basement membrane components and collagen biosynthesis were studied in suction blisters in human skin. The basement membrane components were characterized by immunofluorescence using specific antibodies to type IV collagen, laminin and fibronectin, and collagen biosynthesis was studied by assaying galactosylhydroxylysyl glucosylatransferase. In suction blisters, the separation of epidermis and dermis occurred above the lamina lucida, indicating that the basement membrane, composed of lamina lucida and lamina densa, forms a mechanically strong entity. During the regeneration phase of blisters, type Iv collagen and laminin were not observed in the old epidermal blister roof. This indicates that keratinocytes when separated from the underlying basement membrane or connective tissue do not synthesize laminin or type IV collagen. Galactosylhydroxylysyl glucosyltransferase activity could be demonstrated in blister fluid and was about the same as in serum when expressed on the basis of protein in fresh blisters. It increased by 2-3 fold during the repair of blisters, indicating that there was local production of this enzyme. Further studies revealed that pure epidermis contained galactosylyhdroxylysyl glucosyltransferase and hydroxyprolineand this suggests that epidermis may synthesize some collagen type which, according to these studies, is not type IV (basement memebrane) collagen. [less ▲]

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See detailBasement membrane in differentiating mesonephric and paramesonephric ducts of male and female rat fetuses.
Paranko, J.; Foidart, Jean-Michel ULg; Pelliniemi, L. J.

in Differentiation : Research in Biological Diversity (1985), 29(1), 39-49

The differentiation of male and female rat genital ducts and their basement membranes were studied by light- and electron-microscopic localization of type-IV and -V collagen, laminin, and heparan sulfate ... [more ▼]

The differentiation of male and female rat genital ducts and their basement membranes were studied by light- and electron-microscopic localization of type-IV and -V collagen, laminin, and heparan sulfate proteoglycan at the fetal ages of 15-21 days. At 15 days, the basement membrane of the mesonephric duct was continuous in both sexes, whereas on the medial side of the paramesonephric duct, it was incomplete. The male mesonephric duct remained enveloped by a continuous basement membrane. Increasing accumulation of basement-membrane material in the periductal mesenchyme was regarded as incipient epididymal differentiation. Local expansions and slow degradation of the basement membrane were noted in the regressing female mesonephric duct. The female paramesonephric duct had acquired a continuous basement membrane by the age of 16 days. At this age, the incomplete basement membrane in the medial side of the male paramesonephric duct disappeared, and breaks in the lateral portion appeared. The formation of epitheliomesenchymal contacts and basal cytoplasmic blebs in the epithelial cells of the regressing paramesonephric duct coincided with the disappearance of the basement-membrane material in the condensed periductal mesenchyme. The asymmetric regression of the male paramesonephric duct was initiated in the immature medial side. The changes in the periductal matrix are indications of basic differences in the regulation of the development and regression of the genital ducts in different sexes. [less ▲]

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See detailThe basement membrane proteins laminin and type IV collagen in isolated villi in pre-eclampsia
Risteli, J.; Foidart, Jean-Michel ULg; Risteli, L. et al

in Placenta (1984), 5(6), 541-50

The distribution and concentrations of the basement membrane proteins laminin and type IV collagen were studied in isolated placental villi in normal pregnancy and in pre-eclampsia. In both cases these ... [more ▼]

The distribution and concentrations of the basement membrane proteins laminin and type IV collagen were studied in isolated placental villi in normal pregnancy and in pre-eclampsia. In both cases these proteins could be localized by immunofluorescence in the trophoblast and capillary basement membranes, and occasionally also in the matrix surrounding the capillaries. The basement membrane proteins were quantified by solubilizing the villi with proteolytic enzymes and by subsequently measuring the concentrations of two resistant domains of these proteins (7-S collagen and the fragment PI, representing type IV collagen and laminin, respectively) with specific radioimmunoassays. The ratio type IV collagen:laminin was significantly higher in pre-eclamptic samples than in the controls, most probably reflecting a decrease in laminin concentration in the villi in pre-eclampsia. Such a change in the chemical composition of placental basement membranes could weaken the attachment of trophoblast cells to the underlying basement membrane and also modify the permeability and exchange properties of the villi. [less ▲]

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See detailBases anatomiques: L’innervation abdomino-pelvienne et périnéale.
Bonnet, Pierre ULg

in Beaussier, Marc; Nicolaï, Patrick (Eds.) Anesthésie et Analgésie Loco-régionales en Chirurgie Abdominale et Périnéale (2010)

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See detailBases biologiques du comportement suicidaire: approche neuroendocrinienne et psychophysiologique du role des catecholamines.
Pitchot, William ULg; Hansenne, Michel ULg; Gonzalez Moreno, Antonio et al

in Acta Psychiatrica Belgica (1995), 95(4-5), 210-33

The current main neurochemical theories of the biological correlates of suicidal behavior principally involve the serotonergic system. Few data are available about the possible role of the ... [more ▼]

The current main neurochemical theories of the biological correlates of suicidal behavior principally involve the serotonergic system. Few data are available about the possible role of the catecholaminergic (noradrenergic and dopaminergic) function. In the present study, in a first part, we assessed the growth hormone (GH) response to clonidine, a selective alpha 2-adrenergic agonist, and to apomorphine, a dopaminergic agonist, in 22 DSM-III-R major depressive male inpatients with a history of suicide attempts compared to 22 age-matched major depressive inpatients without history of suicidal behavior. Hormonal responses to clonidine and apomorphine were also compared with 4.00 PM postdexamethasone cortisol levels. The two groups differed significantly in the GH peak response after apomorphine: 6.27 +/- 3.18 ng/ml in suicide attempters vs 17.40 +/- 14.87 ng/ml in nonattempters (F = 11.78, p = 0.001). There was no statistically significant difference between the two groups for GH peak responses after clonidine. Moreover, mean postdexamethasone cortisol levels did not exhibit any significant difference between suicide attempters and nonattempters. Violent and nonviolent attempters did not differ on any of the biological measures. In a second part, P300 and contingent negative variation (CNV) were recorded in 20 depressive inpatients subgrouped into suicide attempters (n = 10) and nonattempters (n = 10). The results showed a significant reduction of both P300 and CNV amplitudes in patients who attempted suicide compared to patients without history of suicide attempts. Moreover, a significant correlation was found between the Suicidal Risk scale and CNV amplitude. In conclusion, these results suggest that a dopaminergic hypoactivity as assessed by a blunted GH response to apomorphine and by a reduction of both P300 and CNV amplitudes, could be considered as a biological correlate of suicidal behavior. In contrast, noradrenergic disturbances, particularly at the level of alpha 2-adrenergic receptors, seem to play a more minor role. Moreover, DST nonsuppression cannot be considered as a biological marker of suicidal behavior. [less ▲]

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See detailBases biologiques et éco-hydrauliques pour la restauration de la continuité piscicole en rivière : premier bilan et perspectives en Région Wallonne (Belgique).
Ovidio, Michaël ULg; Philippart, Jean-Claude ULg; Denoel, Philippe et al

Conference (2008, October)

Dans le prolongement de la Directive Benelux d’avril 1996 (libre circulation des poissons migrateurs) et de la Directive Cadre sur l’Eau de l’Union Européenne (2000/60/CE), le rétablissement de la ... [more ▼]

Dans le prolongement de la Directive Benelux d’avril 1996 (libre circulation des poissons migrateurs) et de la Directive Cadre sur l’Eau de l’Union Européenne (2000/60/CE), le rétablissement de la continuité piscicole dans nos cours d’eau fait partie des objectifs prioritaires de la Direction des Cours d’eau Non Navigables du Ministère de la Région Wallonne. Depuis 1997, différents acteurs, gestionnaires, sociétés de pêches et scientifiques abordent en profondeur cette problématique par l’exécution de différentes actions intégrées. Depuis environ 10 ans, un travail de terrain considérable est accompli pour le compte de la Région wallonne par la Fédération de Pêche Vesdre-Amblève (asbl) qui répertorie et géoréférence la totalité des obstacles physiques susceptibles de perturber la continuité piscicole dans les cours d’eau de Wallonie. En parallèle, le Laboratoire de Démographie des Poissons et d’Hydroécologie (LDPH) de l’Université de Liège étudie l’impact biologique de certains de ces obstacles sur les populations de poissons, principalement en utilisant la technique du radio-pistage. Ces recherches permettent de mieux connaître les phénomènes de mobilité et de migrations des poissons de nos cours d’eau ainsi que leurs capacités à franchir en remontée des obstacles typologiquement très différents. Ces travaux permettent d’identifier les sites critiques qui doivent prioritairement êtres équipés de dispositifs de franchissement efficaces. Le contrôle scientifique du fonctionnement des passes migratoires nouvellement construites démontre clairement leurs effets positifs sur la qualité écologique et piscicole de la rivière. De tels résultats justifient fortement de multiplier ce type d’action de restauration écologique (hydromorphologique) dans d’autres cours d’eau. Au cours de notre exposé, nous présenterons, avec des résultats concrets, un premier bilan des travaux déjà effectués et nous dégagerons les perspectives à moyen et long terme en matière de libre circulation des poissons dans les cours d’eau wallons, non seulement en remontée mais aussi en descente (ou dévalaison). [less ▲]

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See detailBases biologiques et éco-hydrauliques pour la restauration de la continuité piscicole en rivière : premier bilan et perspectives.
Ovidio, Michaël ULg; Philippart, Jean-Claude ULg; Orban, Patrice et al

in Forêt Wallonne (2009), 101(juillet-août), 18-29

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See detailBases d'une croissance du transport intermodal en Belgique
Marchal, Jean ULg; Macharis, Cathy; Lundoluka, Ferdinand et al

Report (2004)

The project "Bases of a growth of intermodal transport in Belgium: the search of “missing links” "is a coherent whole of tasks carried out by two transport research centers, one working within the ... [more ▼]

The project "Bases of a growth of intermodal transport in Belgium: the search of “missing links” "is a coherent whole of tasks carried out by two transport research centers, one working within the university of Liege (Ulg) and the other working within the Vrije Universiteit Brussel (VUB). The two research centers constituted a common team in order to work together on a certain number of topics concerning the transportation in general. This research project is based on various former research projects carried out by the two research centers. These previous researches led to the conclusion that the practitioners as well as the public decision-makers should concentrate on specific elements to stimulate a better growth of the intermodal transport in Belgium. The team has identified four elements which constitute real "missing links", not enough taken into account by the public policy and the administrators of the intermodal transport. These four elements are: 1. A tool to follow the prices of the intermodal transport 2. An analysis of the most critical value added services that should be supplied by the intermodal terminal operators 3. A series of directives to optimize the packaging of the goods to stimulate the intermodal transport 4. An instrument of follow-up of "modal scan" These elements are analysed and each of them constitute an entire module of this report. [less ▲]

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See detailLes bases de données de textes en égyptien
Winand, Jean ULg

in Informatique et Égyptologie (1990), 7

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See detailLes bases de données en égyptologie
Winand, Jean ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1990), 26

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