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Peer Reviewed
See detailAuditory evoked potentials and multiple personality measures in migraine and post-traumatic headaches.
Wang, W.; Wang, Y.-H.; Fu, X. M. et al

in Pain (1999), 79(2-3), 235-42

Migraine sufferers have abnormal cerebral information processing and personality disorders, post-traumatic headache sufferers also have some personality changes. We therefore, studied intensity dependence ... [more ▼]

Migraine sufferers have abnormal cerebral information processing and personality disorders, post-traumatic headache sufferers also have some personality changes. We therefore, studied intensity dependence of auditory evoked potentials, Plutchik-van Praag's depression inventory, Zuckerman's sensation seeking scales and Zuckerman-Kuhlman's personality questionnaire in patients suffering from migraine without aura (n = 26) and chronic post-traumatic headaches (n = 26) as well as in healthy volunteers (n = 30). The migraine group showed significantly increased neuroticism-anxiety than controls, increased intensity dependence of N1-P2, and decreased thrill and adventure score compared with the controls and post-traumatic headaches. The post-traumatic headache had significantly increased depression compared with the controls, and increased disinhibition compared with the controls and migraines. This study demonstrates that the two headache types have different neurophysiological and personality traits. The pronounced intensity dependence of N1-P2 suggests a cortical potentiation response, together with a decreased thrill and adventure seeking, favor a lower serotonergic innervation in migraine. While the elevated disinhibition and depression, as consequences, may be linked with the wide cortical neuronal/axonal degeneration in post-traumatic headache. [less ▲]

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See detailAuditory evoked potentials in the assessment of central nervous system effects of antimigraine drugs.
Roon, K. I.; Sandor, P. S.; Schoonman, G. G. et al

in Cephalalgia : An International Journal of Headache (1999), 19(10), 880-5

Because the "intensity dependence" of cortical auditory evoked potentials (IDAP) is under serotonergic control, it can be used to assess central antimigraine effects of 5HT1B/1D agonists. We measured IDAP ... [more ▼]

Because the "intensity dependence" of cortical auditory evoked potentials (IDAP) is under serotonergic control, it can be used to assess central antimigraine effects of 5HT1B/1D agonists. We measured IDAP before and 2 h after naratriptan (5 mg, n = 19) and zolmitriptan (5 mg, n = 19) in healthy volunteers. IDAP was expressed as the amplitude-stimulus intensity function ("ASF slope"). Naratriptan tended to increase ASF slope (mean difference 0.23 +/- 0.62 microV/10 dB, p = 0.06) while zolmitriptan (0.08 +/- 0.95 microV/10 dB, p = 0.35) did not. We assessed the suitability of IDAP for measuring central antimigraine drug effects using repeatability data (see companion paper). We calculated the trade-off between the size of the expected drug effects (ASF slope difference) and the necessary sample size. Because of poor repeatability 36 to 80 subjects are required to detect ASF slope changes in the 0.25-0.5 microV/10 dB range. These data can be used to design trials using IDAP. [less ▲]

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See detailAuditory forebrain activation in the female canary is modulated by male song quality.
Barker, Jennifer ULg; Monbureau, Marie; Leboucher, Gerard et al

Poster (2010, November 17)

One of the chief functions of birdsong is to attract and stimulate females. In canaries (Serinus canaria), specific phrases (“A” phrases) sung by males have been identified as especially attractive for ... [more ▼]

One of the chief functions of birdsong is to attract and stimulate females. In canaries (Serinus canaria), specific phrases (“A” phrases) sung by males have been identified as especially attractive for females. These phrases unite a number of characteristics that are particularly difficult to combine, including large frequency bandwidth, high repetition rate and multiple-note syllables. Females exposed to “A” phrases produce more copulation displays and deposit more testosterone into their eggs. However, the neuroendocrine pathway underlying the translation of song audition to changes in testosterone deposition in yolks is not understood. Increased expression of several immediate early genes including c-fos and zenk (also called egr-1 in mammals) in other songbird species has been observed in the auditory forebrain of females hearing attractive song, and such differential activation may represent a first step in signal processing linking auditory input to egg testosterone deposition. Female canaries in breeding condition were exposed to 60 minutes of “sexy” song with a preponderance of “A” phrases, “non-sexy” song lacking “A” phrases, or white noise. Thirty minutes after the end of song playback, brains were collected, fixed in acrolein and sectioned and stained by immunohistochemistry for quantification of the Fos protein, an indicator of neuronal activity, in several regions involved in audition and auditory processing. The endocrine condition of each female was determined by measuring ovarian and oviduct weight at the time of autopsy. In the caudomedial mesopallium (CMM), Fos expression was higher in females that had heard sexy song than those that heard non-sexy song or white noise. Expression of Fos in the caudomedial nidopallium (NCM), the nucleus spiriformis medialis (SPM), the nucleus ovoidalis (OV), and the song nucleus HVC was unaffected by song quality. Thus differential auditory processing in the CMM may be an initial stage in the assessment by a female of song information to differential testosterone deposition in the egg. [less ▲]

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See detailAuditory hallucinations in persons with and without a need for care
Johns; Kompus, K; Connell, M et al

in Schizophrenia Bulletin (2014), 40

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See detailAuditory hallucinations in schizophrenia and non-schizophrenia populations: A review and integrated model of cognitive mechanisms
Waters, F.; Aleman, A.; Fernyhough, C. et al

in Schizophrenia Bulletin (2012), 38

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See detailAuditory P300 and the altered consciousness: detecting altered states of consciousness using the P300 speller
Lulé, D.; Kleih, S.; Chatelle, Camille ULg et al

in Proceedings of TOBI Workshop 2010: Integrating Brain-Computer Interfaces with Conventional Assistive Technology (2010)

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See detailThe auditory P300-based single-switch brain–computer interface:Paradigm transition from healthy subjects to minimally consciouspatients
Pokorny, Christoph; Klobassa, Daniela; Pichler, Gerald et al

in Artificial Intelligence in Medicine (2013), 59(2), 81-90

Objective: Within this work an auditory P300 brain–computer interface based on tone stream segregation,which allows for binary decisions, was developed and evaluated.Methods and materials: Two tone ... [more ▼]

Objective: Within this work an auditory P300 brain–computer interface based on tone stream segregation,which allows for binary decisions, was developed and evaluated.Methods and materials: Two tone streams consisting of short beep tones with infrequently appearingdeviant tones at random positions were used as stimuli. This paradigm was evaluated in 10 healthysubjects and applied to 12 patients in a minimally conscious state (MCS) at clinics in Graz, Würzburg,Rome, and Liège. A stepwise linear discriminant analysis classifier with 10 × 10 cross-validation was usedto detect the presence of any P300 and to investigate attentional modulation of the P300 amplitude.Results: The results for healthy subjects were promising and most classification results were better thanrandom. In 8 of the 10 subjects, focused attention on at least one of the tone streams could be detectedon a single-trial basis. By averaging 10 data segments, classification accuracies up to 90.6 % could bereached. However, for MCS patients only a small number of classification results were above chance leveland none of the results were sufficient for communication purposes. Nevertheless, signs of consciousnesswere detected in 9 of the 12 patients, not on a single-trial basis, but after averaging of all correspondingdata segments and computing significant differences. These significant results, however, strongly variedacross sessions and conditions.Conclusion: This work shows the transition of a paradigm from healthy subjects to MCS patients. Promisingresults with healthy subjects are, however, no guarantee of good results with patients. Therefore, moreinvestigations are required before any definite conclusions about the usability of this paradigm for MCSpatients can be drawn. Nevertheless, this paradigm might offer an opportunity to support bedside clinicalassessment of MCS patients and eventually, to provide them with a means of communication. [less ▲]

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See detailAuditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state.
Boly, Mélanie ULg; FAYMONVILLE, Marie-Elisabeth ULg; Peigneux, Philippe ULg et al

in Archives of Neurology (2004), 61(2), 233-8

BACKGROUND: The minimally conscious state (MCS) is a recently defined clinical condition; it differs from the persistent vegetative state (PVS) by the presence of inconsistent, but clearly discernible ... [more ▼]

BACKGROUND: The minimally conscious state (MCS) is a recently defined clinical condition; it differs from the persistent vegetative state (PVS) by the presence of inconsistent, but clearly discernible, behavioral evidence of consciousness. OBJECTIVE: To study auditory processing among patients who are in an MCS, patients who are in a PVS, and healthy control subjects. METHODS: By means of (15)O-radiolabeled water-positron emission tomography, we measured changes in regional cerebral blood flow induced by auditory click stimuli in 5 patients in an MCS, 15 patients in a PVS, and 18 healthy controls. RESULTS: In both patients in an MCS and the healthy controls, auditory stimulation activated bilateral superior temporal gyri (Brodmann areas 41, 42, and 22). In patients in a PVS, the activation was restricted to Brodmann areas 41 and 42 bilaterally. We also showed that, compared with patients in a PVS, patients in an MCS demonstrated a stronger functional connectivity between the secondary auditory cortex and temporal and prefrontal association cortices. CONCLUSIONS: Although assumptions about the level of consciousness in severely brain injured patients are difficult to make, our findings suggest that the cerebral activity observed in patients in an MCS is more likely to lead to higher-order integrative processes, thought to be necessary for the gain of conscious auditory perception. [less ▲]

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See detailAuditory processing in the vegetative state.
Laureys, Steven ULg; Faymonville, Marie ULg; Degueldre, Christian ULg et al

in Brain : A Journal of Neurology (2000), 123 ( Pt 8)

H(2)(15)O-PET was used to investigate changes in regional cerebral blood flow in response to auditory stimulation in patients in the vegetative state. Five patients in a vegetative state of hypoxic origin ... [more ▼]

H(2)(15)O-PET was used to investigate changes in regional cerebral blood flow in response to auditory stimulation in patients in the vegetative state. Five patients in a vegetative state of hypoxic origin were compared with 18 age-matched controls. In addition, the cerebral metabolism of these patients and 53 age-matched controls was studied using [(18)F]fluorodeoxyglucose. In control subjects, auditory click stimuli activated bilateral auditory cortices [Brodmann areas (BA) 41 and 42] and the contralateral auditory association cortices (BA 22). In the patients, although resting metabolism was decreased to 61% of normal values, bilateral auditory areas 41 and 42 showed activation as seen in the controls, but the temporoparietal junction cortex (BA 22) failed to be activated. Moreover, the auditory association cortex was functionally disconnected from the posterior parietal association area (BA 40), the anterior cingulate cortex (BA 24) and the hippocampus, as revealed by psychophysiological interaction analysis. Thus, despite altered resting metabolism, the auditory primary cortices were still activated during external stimulation, whereas hierarchically higher-order multi- modal association areas were not. Such a cascade of functional disconnections along the auditory cortical pathways, from the primary auditory areas to multimodal and limbic areas, suggests that the residual cortical processing observed in the vegetative state cannot lead to the integrative processes that are thought to be necessary for the attainment of the normal level of awareness. [less ▲]

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See detailAuditory resting-state network connectivity in tinnitus: a functional MRI study.
Maudoux, Audrey; Lefèbvre, Philippe ULg; Cabay, Jean-Evrard et al

in PLoS ONE (2012), 7(5), 36222

The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test ... [more ▼]

The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI "resting-state" connectivity patterns in auditory network differ between tinnitus patients and normal controls. Thirteen chronic tinnitus subjects and fifteen age-matched healthy controls were studied on a 3 tesla MRI. Connectivity was investigated using independent component analysis and an automated component selection approach taking into account the spatial and temporal properties of each component. Connectivity in extra-auditory regions such as brainstem, basal ganglia/NAc, cerebellum, parahippocampal, right prefrontal, parietal, and sensorimotor areas was found to be increased in tinnitus subjects. The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus. These results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks. Our data corroborate the hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress leading to disabling chronic tinnitus. [less ▲]

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See detailAuditory Resting-State Network Connectivity in Tinnitus: a Functionnal MRI Study.
MAUDOUX, Audrey ULg; LEFEBVRE, Philippe ULg; CABAY, Jean-Evrard ULg et al

in PLoS ONE (2012)

The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test ... [more ▼]

The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI ‘‘resting-state’’ connectivity patterns in auditory network differ between tinnitus patients and normal controls. Thirteen chronic tinnitus subjects and fifteen age-matched healthy controls were studied on a 3 tesla MRI. Connectivity was investigated using independent component analysis and an automated component selection approach taking into account the spatial and temporal properties of each component. Connectivity in extra-auditory regions such as brainstem, basal ganglia/NAc, cerebellum, parahippocampal, right prefrontal, parietal, and sensorimotor areas was found to be increased in tinnitus subjects. The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus. These results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks. Our data corroborate the hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress. leading to disabling chronic tinnitus. [less ▲]

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See detailauditory sensitivity in birds: sex differences and noise impacts
Noirot, Isabelle ULg

Doctoral thesis (2011)

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See detailAuditory verbal hallucinations and hearing voices
Laroi, Frank ULg

Scientific conference (2011, May 10)

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See detailAuditory verbal hallucinations: dialoguing between the cognitive sciences and phenomenology
Laroi, Frank ULg; de Haan, S.; Jones, S. et al

in Phenomenology and the Cognitive Sciences (2010), 9

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See detailAuditory-verbal hallucinations and ordinary verbal thought
Laroi, Frank ULg

in Psychological Medicine (2009), 39

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See detailAudits de qualités des fournisseurs de produits pharmaceutiques: Aspects théoriques et pratiques
Fotsing, Lucas ULg; Marini Djang'Eing'A, Roland ULg; Ziemons, Eric ULg et al

Learning material (2010)

Vidéo du cours intitulé "Audits de qualités des fournisseurs de produits pharmaceutiques: Aspects théoriques et pratiques".

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See detailAuf dem Weg zu einer neuen institutionellen Technologiefolgenabschätzung. TA in der Wallonie
Delvenne, Pierre ULg; Rosskamp, Benedikt ULg

in Decker, Michael; Bellucci, Sergio; Bröchler, Stephan (Eds.) et al Technilfolgenabschätzung im politischen System (2014, July)

Seit den offensiven Flämischen Technologie-Förderprogrammen in den achtziger Jahren, hat sich der technologische Graben zwischen dem Norden Belgiens und der von Deindustrialisierung stark betroffenen ... [more ▼]

Seit den offensiven Flämischen Technologie-Förderprogrammen in den achtziger Jahren, hat sich der technologische Graben zwischen dem Norden Belgiens und der von Deindustrialisierung stark betroffenen Wallonie weiter entwickelt. Hinzu kommt, dass Flandern im Jahre 2000 eine para-parlamentarische TA Institution eingeführt hat. Ein solches Unterfangen befand sich bis vor kurzem nicht auf der politischen Agenda der Wallonischen Entscheidungsträger. Zwischen 1994 und 2002 missglückte ein erstes TA Experiment, das sich sehr stark an das Baden-Württembergische Regional-TA Modell anlehnte. Zu diesem Zeitpunkt waren die Wallonischen Institutionen noch sehr jung und vor allem mit der Staatsreform befasst. Außerdem war das Interesse der traditionellen Sozialpartner (sprich Arbeitgeber- und Arbeitnehmerverbände) für TA nur bedingt vorhanden und der Bezug zur parlamentarischen Arbeit sehr begrenzt. Wir werden historisch nachverfolgen, wie es zu einer gemeinsamen Regierungserklärung des sozialistischen Ministers für Wirtschaft, Kleinunternehmen, Außenhandel und Neue Technologien sowie Hochschulwesen Jean-Claude Marcourt und des Grünen-Ministers für nachhaltige Entwicklung, öffentliche Ämter, Energie, Wohnungswesen und Forschung Jean-Marc Nollet kam, welche die Gründung eines Instituts für TA vorsieht. Diese ist teilweise zurückzuführen auf eine prospektive Aktionsforschung an der Universität Lüttich aus dem Jahr 2008 die ein weites Spektrum von Innovationsakteuren zu ihrer Haltung gegenüber institutionalisierter TA in der Wallonie befragt hat. Bei der Vorstellung dieser Studie, haben sich eine Reihe von Regionalabgeordneten für die Schaffung eines Instituts für TA ausgesprochen und wenig später eine parlamentarische Resolution verabschiedet. Wir werden auf die organisatorischen und programmatischen Aspekte, wie sie in den Regierungsplänen vorgesehen sind, eingehen. Die Originalität des Wallonischen Projekts ist u.a. der besondere Fokus auf wirtschaftliche Missionen. Mit dem ökonomischen Sektor als Adressaten soll u.a. die Wallonische Wirtschaft in strategischen Technologiebereichen unterstützt werden. Dabei wird viel Hoffnung in das Management von sozial-technologischen Kontroversen und in Wissenschaftskommunikation gesteckt. Neu ist auch der Ansatz, die Tradition der belgischen Sozialkonsultation auf gewisse Stakeholder-Gruppen auszuweiten und die Ambition partizipatorische Methoden zu nutzen, die im Wallonischen Kontext noch wenig verbreitet sind. Das aktuelle Projekt ist jedoch nicht frei von gegenwärtigen politischen Spannungen. Diese hängen sehr stark von parteipolitischen Ansichten sowie unterschiedlichen Positionen der zuständigen Ministerkabinette zur Staatsreform ab. Ferner gilt es auf die Eigenheiten eines solchen Instituts einzugehen und dessen formelle und informelle Adressaten sowie die Verbindung zu weiteren wissenschaftlichen, politischen und administrativen sowie zivilgesellschaftlichen Akteuren zu erläutern. Zuletzt werden wir auf die Besonderheiten der belgischen politischen Institutionen eingehen um besondere Risiken und Herausforderungen einer jungen TA Institution zu skizzieren. [less ▲]

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See detailAufbau und Vermessung eines Regenerators für offene Sorptionssysteme mit flüssigen Sorbentien zur Raumklimatisierung mit Niedertemperaturwärme
Léonard, Grégoire ULg

Master's dissertation (2008)

Travail de fin d'études réalisé dans le cadre d'un échange TIME à l'Université Technique de Munich. Il s'agissait de concevoir et construire un échangeur de chaleur et de matière à plaques pour la ... [more ▼]

Travail de fin d'études réalisé dans le cadre d'un échange TIME à l'Université Technique de Munich. Il s'agissait de concevoir et construire un échangeur de chaleur et de matière à plaques pour la régénération de solvants employés pour la climatisation des bâtiments avec de la chaleur basse température. [less ▲]

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