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See detailAttualità della critica : Persistenze novecentesche tra Francia e Italia
Curreri, Luciano ULg

in Ermeneutica Letteraria (2008), 4

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See detailAn Atypical Anion Transporter Functioning at Acid pH in Neuroblastoma Cells
Bettendorff, Lucien ULg; Margineanu, Ilca; Wins, Pierre et al

in Biochemical and Biophysical Research Communications (1995), 207(1), 375-381

At pH 7.4, 36Cl- uptake by neuroblastoma cells was Na(+)-independent, saturable and blocked by submicromolar concentrations of DIDS. This suggests that at this pH, Cl- transport is mediated by an ... [more ▼]

At pH 7.4, 36Cl- uptake by neuroblastoma cells was Na(+)-independent, saturable and blocked by submicromolar concentrations of DIDS. This suggests that at this pH, Cl- transport is mediated by an exchanger analogous to erythroid band 3. At pH 6. [less ▲]

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See detailAn atypical cell during development of the auditory organ : the inner pillar cell
Thelen, Nicolas ULg; Malgrange, Brigitte ULg; Thiry, Marc ULg

Poster (2007, September)

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far to be elucidated. Using cytochemical and immunohistochemical methods at ... [more ▼]

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far to be elucidated. Using cytochemical and immunohistochemical methods at the light and electron microscope levels, we examined its spatiotemporal development in rats from embryonic day 16 (E16) to E19. <br />At E16, whatever the region of the cochlear studied (base, middle, apex), the organ of Corti is not present. We demonstrate that the organ of Corti develops from a non-proliferative cell zone that is located in the junctional region between the greater epithelial ridge and the lesser epithelial ridge of the cochlear duct and that is characterized by the presence of numerous microvilli. Using the periodic acid-thiocarbohydrazide-silver proteinate method, we reveal that the first cells to develop in this zone are the inner pillar cells, a particular type of nonsensory supporting cells; they arise in the base of the cochlear duct at the boundary between the two ridges at E16. The cell differentiation in this prosensory region continues according to a base-to-apex gradient, the inner hair cells appear in the greater epithelial ridge at E17 and the outer hair cells in the lesser epithelial ridge at E18. At E19, all the different cell types of the organ of Corti are well in place. We also show that the development of the inner pillar cells within the prosensory region does not involve Notch1 signaling. These results highlight the central role that cells could play the inner pillar in the organ of Corti development. [less ▲]

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See detailThe atypical emission-line star Hen 3-209
Nazé, Yaël ULg; Rauw, Grégor ULg; Hutsemekers, Damien ULg et al

in Monthly Notices of the Royal Astronomical Society (2006), 371(4), 1594-1600

We analyse observations, spanning 15 yr, dedicated to the extreme emission-line object Hen 3-209. Our photometric data indicate that the luminosity of the star undergoes marked variations with a peak-to ... [more ▼]

We analyse observations, spanning 15 yr, dedicated to the extreme emission-line object Hen 3-209. Our photometric data indicate that the luminosity of the star undergoes marked variations with a peak-to-peak amplitude of 0.65 mag. These variations are recurrent, with a period of 16.093 +/- 0.005 d. The spectrum of Hen 3-209 is peculiar with many different lines (H I, He I, Fe II,. showing P Cygni profiles. The line profiles are apparently changing in harmony with the photometry. The spectrum also contains [O III] lines that display a saddle profile topped by three peaks, with a maximum separation of about 600 km s(-1). Hen 3-209 is most likely an evolved luminous object suffering from mass ejection events and maybe belonging to a binary system. [less ▲]

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See detailAn atypical member of the light-harvesting complex stress-related protein family modulates diatom responses to light.
Bailleul, Benjamin; Rogato, Alessandra; de Martino, Alessandra et al

in Proceedings of the National Academy of Sciences of the United States of America (2010), 107(42), 18214-9

Diatoms are prominent phytoplanktonic organisms that contribute around 40% of carbon assimilation in the oceans. They grow and perform optimally in variable environments, being able to cope with ... [more ▼]

Diatoms are prominent phytoplanktonic organisms that contribute around 40% of carbon assimilation in the oceans. They grow and perform optimally in variable environments, being able to cope with unpredictable changes in the amount and quality of light. The molecular mechanisms regulating diatom light responses are, however, still obscure. Using knockdown Phaeodactylum tricornutum transgenic lines, we reveal the key function of a member of the light-harvesting complex stress-related (LHCSR) protein family, denoted LHCX1, in modulation of excess light energy dissipation. In contrast to green algae, this gene is already maximally expressed in nonstressful light conditions and encodes a protein required for efficient light responses and growth. LHCX1 also influences natural variability in photoresponse, as evidenced in ecotypes isolated from different latitudes that display different LHCX1 protein levels. We conclude, therefore, that this gene plays a pivotal role in managing light responses in diatoms. [less ▲]

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See detailAtypical metabolisms and biochemical cycles imposing the cancerous state on plant cells
Gaspar, Thomas ULg; Bisbis, Badia; Kevers, Claire ULg et al

in Plant Growth Regulation (1998), 24(2), 135-144

The biological, morphological and biochemical characteristics which define plant cancer cells at the end of a neoplasic progression in the absence of pathogens and which distinguish them from tumorous ... [more ▼]

The biological, morphological and biochemical characteristics which define plant cancer cells at the end of a neoplasic progression in the absence of pathogens and which distinguish them from tumorous cells are summarized. Such plant cancer cells have in common with animal cancer cells many metabolic disturbances. The present paper reviews the biochemical changes in nitrogen, carbon, sugar and heme metabolisms which contribute to polyamine (PAs) accumulation. It indicates how these changes are interconnected and even form between each other biochemical cycles which likely maintain these cells in their irreversible state. The role of these cycles in the maintenance of such cells under a probable permanent oxidative stress is debated. [less ▲]

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See detailAtypical myopathy
Votion, Dominique ULg

in In Proceedings: 50th British Equine Veterinary Association (BEVA) Congress (2011, September 08)

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See detailAtypical myopathy
Votion, Dominique ULg

in In proceedings: European Equine Health & Nutrition Congress (5th edition) (2011, April 16)

Atypical myopathy is a pasture-associated syndrome characterised by the sudden onset of acute rhabdomyolysis apart from any exercise. This frequently fatal acquired condition is intimately linked with the ... [more ▼]

Atypical myopathy is a pasture-associated syndrome characterised by the sudden onset of acute rhabdomyolysis apart from any exercise. This frequently fatal acquired condition is intimately linked with the environment. Atypical myopathy occurs primarily in autumn in Europe and Midwestern United States (Finno et al. 2006) (van Galen et al. 2011a) but outbreaks have also been reported in spring (Votion et al 2003; van Galen et al. 2011a). Atypical myopathy appears to be specific to horses and to the author’s knowledge no other grazing livestock has been confirmed for the disease. In recent years, atypical myopathy has been recognized as an emergent disease (Votion and Serteyn 2008; van Galen et al. 2010). Lately, major advances have been made in the understanding of the pathophysiology of the condition (Cassart et al. 2007; van der Kolk et al. 2010) and causative hypothesis (Unger-Torroledo et al. 2010). The metabolic defect occurring in atypical myopathy affected horses is a multiple acyl-CoA dehydrogenase deficiency (MADD), which affects mitochondrial fatty acid energy metabolism but not the use of carbohydrates for energy supply (van Galen et al. 2008; Westermann et al. 2008). The development of atypical myopathy is probably multifactorial but the condition has been associated with Clostridium sordellii lethal toxin (Unger-Torroledo et al. 2010). However, no specific treatment of the condition exists and the most effective way of controlling the disease is prevention that includes specific management practices at the horse and pasture levels. This review summarises the latest knowledge about atypical myopathy and provides practical information to prevent the disease. [less ▲]

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See detailAtypical myopathy
Gerber, Vinzent; Votion, Dominique ULg

in Robinson, E. (Ed.) Current Therapy in Equine Medicine, 6th edition (2009)

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See detailAtypical Myopathy (Atypical Myoglobinuria)
Votion, Dominique ULg; Amory, Hélène ULg; Demoulin, Vincent ULg et al

in IVIS Reviews in Veterinary Medicine (2004)

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See detailAtypical myopathy (myoglobinuria): 5 cases-based questions.
Votion, Dominique ULg; Serteyn, Didier ULg

Scientific conference (2008, April)

Case-based questions ... and answers!

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See detailAtypical myopathy in Europe: 2006-2009
Van Galen, Gaby ULg; Atypical Myopathy Alert Group; Votion, Dominique ULg

Poster (2010, June 18)

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See detailAtypical Myopathy In Grazing Horses: A First Exploratory Data Analysis
Votion, Dominique ULg; Linden, Annick ULg; Delguste, Catherine ULg et al

in Veterinary Journal (2009), 180(1),

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See detailAtypical myopathy: epidemiology and aetiopathogenesis
Votion, Dominique ULg

in In proceedings: 51th British Equine Veterinary Association (BEVA) Congress (2013, September)

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See detailAtypical myopathy: new insights into the pathophysiology, prevention and management of the condition
Van Galen, Gaby ULg; Serteyn, Didier ULg; Amory, Hélène ULg et al

in Equine Veterinary Education (2008), 20(5), 234-238

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See detailAtypical plasma cells with coexpression of myeloid markers and bundles of Auer rod-like inclusions.
KEUTGENS, Aurore ULg; FOGUENNE, Jacques ULg; Gothot, André ULg et al

in International journal of laboratory hematology (2014)

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See detailAtypical recurrence of a placental site trophoblastic tumor four years after hysterectomy for benign condition: Case report and review of literature.
RAUW, Laetitia ULg; DELBECQUE, Katty ULg; GOFFIN, Frédéric ULg et al

in Gynecologic oncology case reports (2013), 6

*Rare case of PSTT limited to the vagina presenting eight years after last pregnancy and four years after hysterectomy*Differential diagnosis with other vaginal tumors can be challenging but it is ... [more ▼]

*Rare case of PSTT limited to the vagina presenting eight years after last pregnancy and four years after hysterectomy*Differential diagnosis with other vaginal tumors can be challenging but it is critical because behavior and management are different.*Stage-adapted management is proposed and surgery is the mainstay treatment for localized disease. [less ▲]

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See detailAtypical recurrent varicella in 4 patients with hemopathies.
Nikkels, Arjen ULg; Simonart, Thierry; Kentos, Alain et al

in Journal of the American Academy of Dermatology (2003), 48(3), 442-7

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with ... [more ▼]

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with malignant hemopathies who had an unusual form of recurrent varicella develop. Conventional microscopy, immunohistochemistry, and in situ hybridization were applied to smears and skin biopsy specimens. The patients presented a few dozen, scattered, large, papulovesicular lesions with central crusting. No zoster-associated pain or dermatomal distribution of the lesions was noted. Conventional microscopy revealed vascular changes and epidermal alterations typical for alpha-herpes virus infection. The varicella zoster virus major viral envelope glycoproteins gE and gB, and the immediate-early varicella zoster virus IE63 protein and the corresponding genome sequence for gE were detected on Tzanck smears; they were localized in endothelial cells and keratinocytes on skin biopsy specimens. The varicella zoster virus infection in endothelial cells, the vascular involvement, and the widespread distribution of the lesions suggest that the reported eruptions are vascular rather than neural in origin. These findings invalidate the diagnosis of herpes zoster but strongly support the diagnosis of recurrent varicella in an indolent and yet unreported presentation. Furthermore, these eruptions differ from relapsing varicella in children and young adults by the age of the patients, the paucity of clinical lesions, the larger diameter of the lesions and their peculiar clinical aspect, the significantly longer time interval between primary varicella and the recurrence, the prolonged healing time of the lesions, their mild disease course, and the fact that all the lesions are in the same stage of development. [less ▲]

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See detailAtypical subunit composition of the chlorophycean mitochondrial F1FO ATP synthase and role of Asa7 protein in stability and oligomycin resistance of the enzyme.
Lapaille, Marie; Escobar-Ramirez, Adelma; Degand, Hervé et al

in Molecular Biology and Evolution (2010), 27(7), 1630-1644

Background. In yeast, mammals, and land plants, mitochondrial F(1)F(O) ATP synthase (complex V) is a remarkable enzymatic machinery which comprises about 15 conserved subunits. Peculiar among eukaryotes ... [more ▼]

Background. In yeast, mammals, and land plants, mitochondrial F(1)F(O) ATP synthase (complex V) is a remarkable enzymatic machinery which comprises about 15 conserved subunits. Peculiar among eukaryotes, complex V from Chlamydomonadales algae (order of chlorophycean class) has an atypical subunit composition of its peripheral stator and dimerization module, with 9 subunits of unknown evolutionary origin (Asa subunits). In vitro, this enzyme exhibits an increased stability of its dimeric form, and in vivo, Chlamydomonas reinhardtii cells are insensitive to oligomycins, which are potent inhibitors of proton translocation through the F(O) moiety. Methodology/Principal Findings. In this work, we showed that the atypical features of the Chlamydomonadales complex V enzyme are shared by the other chlorophycean orders. By biochemical and in silico analyses, we detected several atypical Asa subunits in Scenedesmus obliquus (Sphaeropleales) and Chlorococcum ellipsoideum (Chlorococcales). In contrast, Complex V has a canonical subunit composition in other classes of Chlorophytes (Trebouxiophyceae, Prasinophyceae, and Ulvophyceae) as well as in Streptophytes (land plants) and in Rhodophytes (red algae). Growth, respiration and ATP levels in Chlorophyceae were also barely affected by oligomycin concentrations that affect representatives of the other classes of Chlorophytes. We finally studied the function of the Asa7 atypical subunit by using RNA interference in C. reinhardtii. Although the loss of Asa7 subunit has no impact on cell bioenergetics or mitochondrial structures, it destabilizes in vitro the enzyme dimeric form and renders growth, respiration and ATP level sensitive to oligomycins. Conclusions/Significance. Altogether, our results suggest that the loss of canonical components of the Complex V stator happened at the root of chlorophycean lineage and was accompanied by the recruitment of novel polypeptides. Such a massive modification of Complex V stator features might have conferred novel properties, including the stabilization of the enzyme dimeric form and the shielding of the proton channel. In these respects, we discuss an evolutionary scenario for F(1)F(O) ATP synthase in the whole green lineage (i.e. Chlorophyta and Streptophyta). [less ▲]

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