Bioconversion of vanillin into vanillic acid by Pseudomonas fluorescens, strain BTP9. I. Cell reactors and mutants study.

in Applied Biochemistry and Biotechnology (1992), 34/35

Bioconversion of vanillin to vanillic acid in free or immobilized cell reactors.

Poster (1990, May)

Bioconversion of vanillin to vanillyl Alcohol by Saccharomyces cerevisiae.

Poster (1986, May)

Bioconversion of vanillin to vanillyl alcohol in a two-phase reactor by Saccharomyces cerevisiae.

Poster (1987, December)

Bioconversion of xylose into xylitol by Pachysolen tannophilus.

Poster (1987, October 01)

Biodegradable and biocompatible inorganic-organic hybrid materials. 1. Synthesis and characterization

in Journal of Polymer Science Part A-Polymer Chemistry (1997), 35(11), 2295-2309

The hydroxyl or vinyl end-groups of linear or three-arm star-shaped poly(-caprolactone) (PCL) chains have been derivatized into triethoxysilane groups reactive in the sol-gel process. New transparent ... [more ▼]

The hydroxyl or vinyl end-groups of linear or three-arm star-shaped poly(-caprolactone) (PCL) chains have been derivatized into triethoxysilane groups reactive in the sol-gel process. New transparent hybrid materials that combine tetraethylorthosilicate (TEOS) and PCL known for biodegradability and biocompatibility have accordingly been prepared. The sol-gel process is, however, limited by the early vitrification of the reactive system. However, thermal posttreatment can overcome these diffusional and/or kinetic limitations as assessed by a set of analytical methods. The thermal stability of PCL is improved by incorporation into the silica network. Conversely, the thermal stability of the ceramer depends on the effective PCL content. The extent of PCL incorporation into the silica network depends on PCL molecular weight, number, and reactivity of the PCL functional groups. IR spectroscopy has shown that hydrogen bonding occurs between the ester groups of PCL and residual OH groups of the silicate component. © 1997 John Wiley [less ▲]

Biodegradable and biocompatible inorganic-organic hybrid materials. 3. A valuable route to the control of the silica porosity

in Langmuir (1998), 14(7), 1905-1910

Porous silica has been successfully prepared from poly(epsilon-caprolactone)-silica hybrid materials on the basis of the template approach. The final texture of the porous silica has been analyzed by the ... [more ▼]

Porous silica has been successfully prepared from poly(epsilon-caprolactone)-silica hybrid materials on the basis of the template approach. The final texture of the porous silica has been analyzed by the nitrogen adsorption-desorption technique and by small-angle X-ray scattering (SAXS). The porosity of silica can be tailored by the poly(epsilon-caprolactone) (PCL) template, particularly molecular weight, molecular weight distribution, content, and type and number of reactive groups per chain. Increasing the molecular weight, content, and chain polydispersity of the PCL template and decreasing the reactivity and number of reactive groups per PCL chain result in a more heterogeneous microporosity and, as a rule, in larger pores, a broader pore size distribution, a larger specific surface area, and a larger total and microporous volume. [less ▲]

Biodegradable and macroporous polylactide implants for cell transplantation : 1. Preparation of macroporous polylactide supports by solid-liquid phase separation

in Polymer (1996), 37(6), 1027-1038

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing ... [more ▼]

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing and formulation parameters. The effects of polymer concentration, chain stereoregularity, polymer molecular weight and cooling rate have been investigated in connection with the porous morphology and the physico-mechanical characteristics of the final foams. As a rule, bundles of channels are formed with a diameter of ~100 μ.m. They have a preferential orientation that fits the cooling direction. A porous substructure (~10 μm) is observed in the internal walls of the tubular macropores. Variations in this general porous morphology-and particularly in the porosity, density, solvent residue, mechanical resistance and degree of regularity in the spatial organization of pores-have been observed when polymer concentration in 1,4-dioxane and polylactide stereoregularity are changed. As expected, cooling rate has a strong effect on the foam morphology, which is essentially controlled by the solvent crystallization. Pores are nothing but the fingerprints of 1,4-dioxane crystallites. [less ▲]

Biodegradable microcarriers based on chitosan and polyesters for tissue engineering

Conference (2012)

Biodegradable microparticles loaded with thrombin receptor agonist peptide for gastric ulcer treatment in rats

in Journal of Drug Delivery Science and Technology (2006), 16(4, JUL-AUG), 321-325

The aim of the current paper was to elaborate an immobilization method of thrombin receptor agonist peptide (TRAP-6) in biodegradable biocompatible poly(d,l)-lactide-co-glycolide (PLGA) inicroparticles ... [more ▼]

The aim of the current paper was to elaborate an immobilization method of thrombin receptor agonist peptide (TRAP-6) in biodegradable biocompatible poly(d,l)-lactide-co-glycolide (PLGA) inicroparticles and to demonstrate the effect of the entrapped peptide for tissue repair, namely,for a gastric ulcer treatment in rats. TRAP-6 was entrapped in polymer using w/o/w double emulsion-evaporation technique. The morphology of empty and TRAP-6 loaded microparticles was evaluated by light and scanning electron microscopy (SEM). In vitro release kinetics profile of TRAP-6 from microparticles was studied by HPLC. To investigate gastric mucosal protection effect in vivo, TRAP-6-loaded microparticles were administered in a rat stomach after a previous mucosal injury (a gastric ulcer). Microparticles with entrapped TRAP-6 were found to reduce both an inflammation and proliferation phases of wound healing, and thus accelerated tissue repair in rats. [less ▲]