Biochemical approach to bovine leukosis

in Acta Haematologica (1975), 54

Biochemical biomarkers of oxidative collagen damage.

in Advances in Clinical Chemistry (2009), 49

Collagens are major constituents of connective tissues in the animal kingdom. During aging and inflammatory-related diseases, the collagen network undergoes oxidation that leads to structural and ... [more ▼]

Collagens are major constituents of connective tissues in the animal kingdom. During aging and inflammatory-related diseases, the collagen network undergoes oxidation that leads to structural and biochemical alterations within the collagen molecule. Collagen oxidation appears to be a key determinant of aging and a critical physiopathologic mechanism of numerous diseases. Further, the detection of oxidized-collagen peptides seems to be a promising approach for the diagnosis and the prognosis of inflammatory diseases. This chapter reviews the structural and biochemical changes to collagen induced by reactive oxygen and nitrogen species and discusses recent data on the use of collagen-derived biomarkers for measuring oxidative damage. [less ▲]

Biochemical changes in patients at risk from the adult respiratory distress syndrome: does the pancreas play a role?

in Kox, W.; Bihari, D. (Eds.) Current concepts in critical care - Shock and the adult respiratory distress syndrome (1988)

Biochemical evidence of antiresorptive effect of risedronate in established osteoporosis

in Osteoporosis International (1996), 6(S1), 249

Biochemical features of bovine leukemia virus.

in Veterinary Microbiology (1976), 1

Biochemical investigation of myocardial infarction

Conference (1996, February 06)

Biochemical markers and radiographic scores as an evaluation for the osteoarticular status of Warmblood stallions.

(2009)

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could potentially be an alternative to this procedure ... [more ▼]

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could potentially be an alternative to this procedure which is time consuming and sometimes technically difficult. The aim of this study was to investigate the relationship between the radiological status of the horses and the levels of biochemical markers (BM) of cartilage degradation and synovial inflammation. Materials and Methods: A specific radiological scoring (RS) system was developed and applied on 63 stallions presented for studbook admission. Additionally, groups of horses were established according to the occurrence of osteochondrosis (OC), degenerative joint disease (DJD) and distal interphalangeal joint (DIPJ) effusion. Insulin growth factor-I, myeloperoxidases, Coll2-1 and Coll2-1NO2 were used as BM. The effects of age and weight on the BM and of the BM on the RS were measured. Mean values of BM between OC positive versus negative, DJD positive versus negative and DIPJ effusion positive versus negative were compared using SAS statistical program. Results: No effect of the combined BM was found on the RS. No significant differences between the values of the BM were found within the different radiological classes (RC). However, considering only the Coll2-1NO2 marker, the probability to belong to class A was given by the equation 9.63 -0.31 Coll2-1NO2 + 0.04 (Coll2-1NO2)². Equally a tendency (p= 0.06) towards an increase in RC by 0.45 for each increasing unit of Coll2-1NO2 was present. Significant positive correlations were found between Coll2-1 values and Coll2-1 NO2 values. MPO values were found to be significantly higher in OC negative horses (357.86  64.43 ng/ml) than in OC positive horses (231.17  27.15 ng/ml). IGF-I levels were found significantly lower in the positive DIPJ effusion group (416.05  17.57 ng/ml) compared to the negative DIPJ effusion group (477.1  22.40 ng/ml). Coll2-1 values were significantly higher in the positive DIPJ effusion group (911.04  41.13 nM) compared to the negative DIPJ effusion group (769.04  37.92 nM). Mean values of Coll2-1 were significantly higher in the DJD positive group (901.24  36.75 nM) compared to the DJD negative group (790.590  39.397 nM) Discussion: The combination of the blood parameters did not seem to correlate with the used RS system. Coll2-1NO2 levels however tend to increase with poorer RC and could therefore be used as a useful predictor of the osteoarticular status of the horse. Coll2-1 levels were significantly higher in the degenerative joint disease group. A high percentage of horses with DIPJ effusion was present in this study and was associated with decreased IGF-I and increased Coll2-1 levels. [less ▲]

Biochemical markers in glucocorticoid-induced osteoporosis

in Giustina, A.; Angeli, A.; Canalis, E. (Eds.) et al Glucocorticoid-induced osteoporosis (2002)

Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis

in Journal of Rheumatology (2003), 30(5), 1043-50

OBJECTIVE: To investigate the relationship between biochemical markers of bone and cartilage remodeling and severity or progression (symptoms and structure) of knee osteoarthritis (OA). METHODS: Mean and ... [more ▼]

OBJECTIVE: To investigate the relationship between biochemical markers of bone and cartilage remodeling and severity or progression (symptoms and structure) of knee osteoarthritis (OA). METHODS: Mean and minimal joint space width (JSW) of the femorotibial joint were measured from standardized radiographs taken at baseline and at the end of a 3-year longitudinal study of patients with knee OA. Pain, stiffness, and physical function subscales of the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index were assessed at the same time points. Biochemical markers [serum keratan sulfate (KS), serum hyaluronic acid (HA), urine pyridinoline (PYD) and deoxypyridinoline (DPD), serum osteocalcin (OC), cartilage oligomeric matrix protein (COMP)] were assessed at baseline and after 1 year. RESULTS: At baseline, no significant correlations were observed between values of biochemical markers and JSW or any of the WOMAC scores. Baseline markers were not correlated with 3-year percentage changes observed in mean or minimal JSW and WOMAC scores. Changes observed after 1 year in OC and HA were significantly correlated with 3-year progression in mean JSW (r = -0.24, p = 0.04 and r = 0.27, p = 0.02, respectively) and in minimal JSW (r = -0.31, p = 0.01 and r = 0.24, p = 0.04, respectively). In patients from the lowest quartile of 1-year changes in HA (< -21.22 ng/ml), mean JSW decreased after 3 years by 0.76 (1.23) mm compared to an increase of 0.11 (0.83) mm in patients in the highest quartile (> +14.34 ng/ml) (p = 0.03). CONCLUSION: The 3-year radiological progression of knee OA could be predicted by a 1-year increase in OC or a 1-year decrease in HA levels. [less ▲]

Biochemical markers of bone metabolism in Ardennes horses

Poster (2006, January)