A Systematic NMR Determination of α-D-Glucooligosaccharides, Effect of Linkage Type, Anomeric Configuration and Combination of Different Linkages Type on 13C Chemical Shifts for the Determination of Unknown Isomaltooligosaccharides

in Bulletin of the Korean Chemical Society (2009), 30(11), 2535-2541

Prebiotic isomaltooligosaccharide preparations contain α-D-glucooligosaccharides comprising isomaltooligosaccharides (IMOs) and non-prebiotic maltooligosaccharides (MOs). They are both glucose ... [more ▼]

Prebiotic isomaltooligosaccharide preparations contain α-D-glucooligosaccharides comprising isomaltooligosaccharides (IMOs) and non-prebiotic maltooligosaccharides (MOs). They are both glucose oligosaccharides characterized by their degree of polymerization (DP) value (from 2 to ~10), linkage types and positions (IMOs: α-(12, 3, 6 and in a lower proportion internal 14) linkages, Mos: -(14) linkages). Their structure is the key factor for their prebiotic potential. In order to determine and elucidate the exact structure of unknown IMOs and Mos, unambiguous assignments of 13C and 1H chemical shifts of commercial standards, representative of IMOs and Mos diversity, have been determined using optimized standard one and two-dimensional experiments such as 1H NMR, 13C NMR, APT and 1H-1H COSY, TOCSY, NOESY and 1H-13C heteronuclear HSQC, HSQC-TOCSY, and HMBC. Here we point out the differential effect of substitution by a glucose residue at different positions on chemical shifts of anomeric as well as ring carbons together with the effect of the reducing end configuration for low DP oligosaccharides and diasteroisotopic effect for H-6 protons. From this study, structural 13C specific spectral features can be identified as tools for structural analysis of isomaltooligosaccharides. [less ▲]

Systematic processing of β – tricalcium phosphate for efficient protein loading and in vitro analysis of antigen uptake

in Advanced Engineering Materials (2013), 15(4), 295-301

Microparticulate calcium phosphate (CaP) powders are promising drug carriers because of their biocompatibility and degradability under physiological conditions. The adsorption capability of CaP ... [more ▼]

Microparticulate calcium phosphate (CaP) powders are promising drug carriers because of their biocompatibility and degradability under physiological conditions. The adsorption capability of CaP microparticles makes them interesting candidates, within the inorganic carrier materials, for delivering protein antigens to professional antigen presenting cells (APC) for vaccination purpose. However, in order to bind and deliver a sufficient amount of protein, the challenge is to effectively increase the binding capacity of this material. In this study, b-tricalcium phosphate (b-TCP) powder is engineered to obtain microparticles with increased protein loading, using bovine serum albumin as a model antigen. The decrease in particle size and increase in specific surface area of carrier is shown to strongly affect protein adsorption. Finally, we demonstrate that the processed b-TCP is capable of delivering its protein payload in vitro to dendritic cells, which are professional APCs and the target cell population for microparticulate vaccines. [less ▲]

Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis.

in Journal of Veterinary Internal Medicine (2012), 26(3), 448-56

BACKGROUND: Various treatments of osteoarthritis (OA) have been described, including use of nutraceuticals. OBJECTIVES: To review systematically the literature about the effects of nutraceuticals on ... [more ▼]

BACKGROUND: Various treatments of osteoarthritis (OA) have been described, including use of nutraceuticals. OBJECTIVES: To review systematically the literature about the effects of nutraceuticals on clinical signs of pain or abnormal locomotion in horses, dogs, and cats, and to discuss methodological aspects of trials and systematic reviews. METHODS: A systematic search of controlled trials evaluating the impact of nutraceuticals on OA in horses, dogs, and cats was performed, using Medline, CAB Abstracts, and Google Scholar. Scientific evidence was evaluated by means of criteria proposed by the Food and Drug Administration (FDA), and a scoring system adapted from both the CONsolidated Standards of Reporting Trials (CONSORT) statement and recommendations for assessing trials by the Center of Evidence Based Medicine of Oxford. RESULTS: Twenty-two papers were selected and reviewed, with 5 studies performed in horses, 16 in dogs, and 1 in cats. The strength of evidence was low for all nutraceuticals except for omega-3 fatty acid in dogs. There were limited numbers of rigorous randomized controlled trials and of participants in clinical trials. CONCLUSIONS AND CLINICAL IMPORTANCE: The evidence of efficacy of nutraceuticals is poor, with the exception of diets supplemented with omega-3 fatty acids in dogs. Greater access to systematic reviews must be part of the objectives of the veterinary science in the future. Their reporting would be improved by internationally agreed-upon criteria for standards and guidelines. [less ▲]

Systematic Search for Quasar Candidates using the MAMA Microdensitometer

in Mc Gillivray, H. T.; Thomson, E. B.; Lasker, B. M. (Eds.) et al Astronomy from wide-field imaging (1994)

Not Available

A systematic view on medical informatics.

in Computer Methods & Programs in Biomedicine (1996), 51(3), 131-9

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics ... [more ▼]

Medical informatics is defined as the scientific discipline concerned with the systematic processing of data, information and knowledge in medicine and health care. The domain of medical informatics (including health informatics), its aim, methods and tools, and its relevance to other disciplines in medicine and health sciences are outlined. It is recognized that one of the major tasks of medical informatics is modelling processes. In this context, biological, communication, decision, engineering, educational, organizational and computational processes are distinguished and described. [less ▲]

Systembiologie: Integration von Modellierung und Experiment-Am Beispiel der Apoptosesignalwege

Scientific conference (2007, December 19)

Le système anglais présagerait-il de l'avenir en matière de qualité de l'enseignement universitaire en Communauté française de Belgique ?

in Actes du 22e congrès de l’Association internationale de pédagogie universitaire (AIPU) (2006)

Issues du monde industriel, les démarches d'amélioration de la qualité se sont rapidement étendues aux autres secteurs. Elles faisaient cependant défaut au niveau de l'enseignement supérieur en Communauté ... [more ▼]

Issues du monde industriel, les démarches d'amélioration de la qualité se sont rapidement étendues aux autres secteurs. Elles faisaient cependant défaut au niveau de l'enseignement supérieur en Communauté française de Belgique. Comblant cette lacune, celle-ci vient de se doter d'un outil de gestion de la qualité de son enseignement. L’Agence d’Evaluation de la Qualité de l'Enseignement Supérieur (AEQES) a été constituée au premier janvier 2003. La première réunion s'est tenue un an plus tard (23 janvier 2004). Elle doit permettre de répondre aux recommandations européennes déjà arrêtées en la matière, d’assurer la représentation de la Communauté française de Belgique dans les instances concernées, mais surtout de doter cette communauté d'une structure organisant l'évaluation de la qualité de l'enseignement au sein des établissements. Dans ce contexte, il est peu probable d’échapper à un courant d’inspiration anglo-saxonne en matière de qualité de l’enseignement supérieur dans lequel le processus qualité est considéré comme un ROI (Return On Investment) ou un processus d'amélioration continue dépendant des moyens (humains, technologiques, financiers, …) qui lui sont consacrés. Le cas qui suit concerne le travail de réflexion d’une trentaine de professionnels autour de la démarche qualité dans l’enseignement supérieur en Communauté française de Belgique. [less ▲]

Le système belge des brevets au 19ème siècle

in Actes du colloque "Nouvelles sources, nouvelles approches, nouvelles méthodes dans la recherche historique (in press)

Le système chromatique dans le Corpus aristotélicien

Master's dissertation (1976)

Système d’annotation interlinéaire interactive de textes grecs et latins, à usage pédagogique

Software (2012)