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See detailRadiation enhances the invasive potential of primary glioblastoma cells via activation of the Rho signaling pathway.
Zhai, Gary G; Malhotra, Rajeev; Delaney, Meaghan et al

in Journal of neuro-oncology (2006), 76(3), 227-37

Glioblastoma multiforme (GBM) is among the most treatment-refractory of all human tumors. Radiation is effective at prolonging survival of GBM patients; however, the vast majority of GBM patients ... [more ▼]

Glioblastoma multiforme (GBM) is among the most treatment-refractory of all human tumors. Radiation is effective at prolonging survival of GBM patients; however, the vast majority of GBM patients demonstrate progression at or near the site of original treatment. We have identified primary GBM cell lines that demonstrate increased invasive potential upon radiation exposure. As this represents a novel mechanism by which radiation-treated GBMs can fail therapy, we further investigated the identity of downstream signaling molecules that enhance the invasive phenotype of irradiated GBMs. Matrigel matrices were used to compare the extent of invasion of irradiated vs. non-irradiated GBM cell lines UN3 and GM2. The in vitro invasive potential of these irradiated cells were characterized in the presence of both pharmacologic and dominant negative inhibitors of extracellular matrix and cell signaling molecules including MMP, uPA, IGFR, EGFR, PI-3K, AKT, and Rho kinase. The effect of radiation on the expression of these signaling molecules was determined with Western blot assays. Ultimately, the in vitro tumor invasion results were confirmed using an in vivo 9L GBM model in rats. Using the primary GBM cell lines UN3 and GM2, we found that radiation enhances the invasive potential of these cells via activation of EGFR and IGFR1. Our findings suggest that activation of Rho signaling via PI-3K is required for radiation-induced invasion, although not required for invasion under physiologic conditions. This report clearly demonstrates that radiation-mediated invasion is fundamentally distinct from invasion under normal cellular physiology and identifies potential therapeutic targets to overcome this phenomenon. [less ▲]

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See detailRadiation Leukemia Virus: A Marker for the Study of Intrathymic T Cell Differentiation
Boniver, Jacques ULg; Delvenne, Catherine ULg; Janowski, M. et al

in Thymus (1989), 14(1-3), 109-13

Radiation Leukemia Virus (RadLV) is a retrovirus, which displays a highly specific thymotropism; after inoculation into young C57 BL/Ka mice, active virus replication is observed only in thymocytes and ... [more ▼]

Radiation Leukemia Virus (RadLV) is a retrovirus, which displays a highly specific thymotropism; after inoculation into young C57 BL/Ka mice, active virus replication is observed only in thymocytes and thymic lymphomas develop in most treated mice. The specific interaction between RadLV and the thymus resides in the particular susceptibility to infection of the most immature cells involved in the intrathymic lymphoid differentiation pathway and of non lymphoid thymic stromal cells. Recent data obtained from 'in situ' hybridization studies for detection of viral transcripts yield more detailed informations on these intriguing interactions. [less ▲]

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See detailRadiation Modeling of a Hydrogen Fueled Scramjet
Crow, Andrew J.; Boyd, Iain D.; Terrapon, Vincent ULg

in Journal of Thermophysics and Heat Transfer (2013), 27(1), 11-21

With the difficulty and cost of full-scale flight experiments, the design of scramjet engines relies heavily on computational simulations. Radiation may play an important role in the wall heating and flow ... [more ▼]

With the difficulty and cost of full-scale flight experiments, the design of scramjet engines relies heavily on computational simulations. Radiation may play an important role in the wall heating and flow cooling of scramjets. However, very few studies have focused on such. The present analysis is based on three-dimensional turbulent reacting flow simulations of the HyShot II hydrogen fueled scramjet engine running at flight conditions of Mach 7.4. A three-dimensional discrete ordinates method analysis with a narrowband averaged spectral model is employed to determine wall heating and flow cooling from thermal radiation. The discrete ordinates method is verified against a three-dimensional ray tracing method. The radiative species considered are H2O and OH. The radiative heat flux is on the order of 10 kW∕m2, which is 0.1–0.6% of the total convective wall heat flux. Flow cooling due to radiation is found to be on the order of 3 K. Sensitivity analysis shows that radiation is highly dependent on chamber size, temperature, pressure, and radiative species mole fraction. Variations in these factors can explain the differences between previous analyses in the literature that studied hypothetical engines and the current work that models an existing scramjet. [less ▲]

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See detailRadiation Modeling of a Hydrogen-Fueled Scramjet
Crow, Andrew J.; Boyd, Iain D.; Terrapon, Vincent ULg

in 42nd AIAA Thermophysics Conference 2011, Vol. 3; No AIAA 2011-3769 (2011, June)

With the difficulty and cost of full-scale flight experiments, the design of scramjet engines relies heavily on computational simulations. Radiation may play an important role in wall heating and flow ... [more ▼]

With the difficulty and cost of full-scale flight experiments, the design of scramjet engines relies heavily on computational simulations. Radiation may play an important role in wall heating and flow cooling of scramjets. However, very few studies have focused on such. The present analysis is based on three-dimensional turbulent reacting flow simulations of the HyShot II hydrogen fueled scramjet engine running at flight conditions of Mach 7.4. A one-dimensional Discrete Ordinates Method analysis with a narrow band averaged spectral model is employed to determine wall heating and flow cooling from thermal radiation. The one-dimensional Discrete Ordinates Method is verifi ed against a three-dimensional ray tracing method. The radiative species considered are H2O and OH. The radiative heat flux is on the order of 10 kW/m2, which is 0.1-0.2% of the total convective wall heat flux. Flow cooling due to radiation is found to be on the order of 2 K. Sensitivity analysis shows that radiation is highly dependent on chamber size, temperature, pressure and radiative species mole fraction. Variations in these factors can explain the differences between previous analyses in the literature that studied hypothetical engines and the current work that models an existing scramjet. [less ▲]

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See detailRADIATION SHIELDING OF COMPOSITE SPACE ENCLOSURES
Atxaga, G.; Marcos, J.; Jurado, M. et al

Conference (2012, October)

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through ... [more ▼]

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through the shield material, such that the energy per unit mass (or dose) absorbed in silicon is sufficiently below the maximum dose ratings of electronic components. The received radiation amount varies significantly depending on several variables that include mission parameters (orbit, altitude, inclination and duration), spacecraft design (spacecraft wall thickness and panel-enclosure location). To achieve the optimum shielding with the minimum weight, all these variables have to be considered in the design. Energetic particles, mainly electrons and protons, can destroy or cause malfunctions in spacecraft electronics. The standard practice in space hardware is the use of aluminium as both a radiation shield and structural enclosure. Composite structures show potential for significant mass savings. However, conventional graphite epoxy composites are not as efficient shielding materials as aluminium because of their lower density, that is, for the same mass, composites provide 30 to 40% less radiation attenuation than aluminium. A solution is to embed high density (atomic weight) material into the laminate. This material, typically metallic material, can be dispersed in the composite or used as layers in the laminate (foils). The main objective of the “Radiation Shielding of Composite Space Enclosures” (SIDER) project is the development of the technologies and tools required to obtain lightweight, safe, robust and reliable composite structures. Two different strategies are being analysed as alternatives for radiation shielding: and he incorporation of a high density material foil. This paper will present and analyse the radiation shielding obtained by the incorporation of nanomaterials in composite structures. [less ▲]

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See detailRadiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?
Zouhair, A; COUCKE, Philippe ULg; Jeanneret, W et al

in European Journal of Cancer (2000), 37(2), 198203

To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the ... [more ▼]

To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35–76 years). According to the International Union Against Cancer (UICC) 1997 classification, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classification was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20–331 months). In a median period of 12 months (range 5–139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy ±postoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5- and 10-year survival rates were 57% (95% confidence interval (CI), 41–73%) and 38% (95% CI, 21–55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41–73%) and 48% (95% CI, 32–64%), respectively. In patients treated with primary radiotherapy, 5- and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22–50%) and 18% (95% CI, 2–34%), respectively. In multivariate analyses, survival was significantly influenced by the N-classification, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squamous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no difference in terms of survival between patients treated by surgery and those treated by primary radiotherapy ±salvage surgery, with 39% having organ preservation. [less ▲]

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See detailRadiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?
Zouhair, A; COUCKE, Philippe ULg; Jeanneret, W et al

in European Journal of Cancer (2001), 37

Abstract To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of ... [more ▼]

Abstract To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35±76 years). According to the International Union Against Cancer (UICC) 1997 classi®cation, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classi®cation was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20±331 months). In a median period of 12 months (range 5±139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy postoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5- and 10-year survival rates were 57% (95% con®dence interval (CI), 41±73%) and 38% (95% CI, 21± 55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41±73%) and 48% (95% CI, 32±64%), respectively. In patients treated with primary radiotherapy, 5- and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22±50%) and 18% (95% CI, 2±34%), respectively. In multivariate analyses, survival was signi®cantly in¯uenced by the N-classi®- cation, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squa- mous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no di erence in terms of survival between patients treated by surgery and those treated by primary radiotherapy salvage surgery, with 39% having organ preservation. [less ▲]

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See detailRadiation therapy duration influences overall survival in patients with cervix carcinoma.
Coucke, Philippe ULg; Delaloye, J-F; Pampallona, S et al

in International Journal of Gynecology & Obstetrics (1997), 57

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation ... [more ▼]

of the cervix treated by radical radiation therapy. Method; Three hundred and sixty patients with FIG0 stage IB-IIIB carcinoma of the cervix were treated in Lausanne (Switzerland) with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to the duration of the therapies, taking 60 days (the 75th percentile) as an arbitrary cut-off. Results: The 5-year survival was 61% (SE. = 3%) for the therapy duration group of less than 60 days and 53% (SE. = 7%) for the group of more than 60 days. In terms of univariate hazard ratio (HR), the relative difference between the hvo groups corresponds to a 50% increase of deaths (HR = 1.53, 95% CI = 1.03-2.28) for the longer therapy duration group (P = 0.044). In a multivariate analysis, the magnitude of estimated relative hazards for the longer therapies are confirmed though significance was reduced (HR = 1.52, 95% CI = 0.94-2.45, P = 0.084). Conclusion: These findings suggesthat short treatment duration is a factor associated with longer survival in carcinoma of the cervix. 0 1997 International Federation of Gynecology and Obstetrics [less ▲]

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See detailRadiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.
Egger, J-F; Coindre, J-M; Benhattar, J et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2002), 15(9), 998-1004

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant ... [more ▼]

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004 [less ▲]

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See detailRadiation-curing binders and a process for their preparation
Greszta-Franz, Dorota; Fischer, Wolfgang; Weikard, Jan et al

Patent (2006)

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic ... [more ▼]

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing group s) and 3) optionally NCO-reactive groups, by reacting at temperatures .ltoreq. 130.degree.C A) one or more NCO-functional compounds containing uretdione groups wit h B) one or more compounds that contain isocyanate-reactive groups and groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and then C) with one or more saturated, hydroxyl-containing compounds other than B ), at least one of these compounds having an OH functionality of .gtoreq. 2, in the presence of D) a catalyst containing one or more zinc compounds, the reaction with compounds C) taking place at least proportionally with the formation of allophanate groups. The present invention also relates to the binders obtained by the process of the invention. [less ▲]

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See detailRadiation-curing binders and a process for their preparation
Weikard, Jan; Detrembleur, Christophe ULg; Greszta-Franz, Dorota et al

Patent (2006)

A binder is prepared by reacting isocyanate-functional compound(s) containing uretdione groups; compounds that contain isocyanate-reactive groups and contain groups that react with ethylenically ... [more ▼]

A binder is prepared by reacting isocyanate-functional compound(s) containing uretdione groups; compounds that contain isocyanate-reactive groups and contain groups that react with ethylenically unsaturated compounds; saturated, hydroxyl-containing compound(s); and a catalyst containing ammonium salts or phosphonium salts of aliphatic or cycloaliphatic carboxylic acids. Preparation of a binder containing allophanate groups, groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and optionally isocyanate (NCO)-reactive groups, which comprises reacting at 130[deg]C NCO-functional compound(s) containing uretdione groups; compounds that contain isocyanate-reactive groups and contain groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups); saturated, hydroxyl-containing compound(s), at least one of these compounds having an OH functionality of 2; and a catalyst containing one or more ammonium salts or phosphonium salts of aliphatic or cycloaliphatic carboxylic acids, the reaction hydroxyl-containing compounds taking place at least proportionally with the formation of allophanate groups. An independent claim is also included for a coating composition comprising: (1) binders; (2) optionally polyisocyanate(s) which contain free or blocked isocyanate groups and optionally contain groups which react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation; (3) optionally compounds other than the polyisocyanate(s) which contain groups which react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation and optionally contain NCO-reactive groups; (4) optionally isocyanate-reactive compound(s) which are free from groups which react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation; and (5) initiators. [less ▲]

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See detailRadiation-curing binders and a process for their preparation
Detrembleur, Christophe ULg

Patent (2006)

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic ... [more ▼]

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups) and 3) optionally NCO-reactive groups, by reacting at temperatures <=130 DEG C. A) one or more NCO-functional compounds containing uretdione groups with B) one or more compounds that contain isocyanate-reactive groups and groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and then C) with one or more saturated, hydroxyl-containing compounds other than B), at least one of these compounds having an OH functionality of >=2, in the presence of D) a catalyst containing one or more zinc compounds, the reaction with compounds C) taking place at least proportionally with the formation of allophanate groups. The present invention also relates to the binders obtained by the pro cess of the invention. [less ▲]

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See detailRadiation-curing binders and a process for their preparation
Weikard, Jan; Greszta-Franz, Dorota; Fischer, Wolfgang et al

Patent (2006)

PROBLEM TO BE SOLVED: To provide a process for preparing a binder which contains (1) an allophanate group, (2) a group that reacts with an ethylenically unsaturated compound with polymerization on ... [more ▼]

PROBLEM TO BE SOLVED: To provide a process for preparing a binder which contains (1) an allophanate group, (2) a group that reacts with an ethylenically unsaturated compound with polymerization on exposure to actinic radiation (radiation-curing group) and (3) optionally an NCO-reactive group; and to provide the binder obtained by the process. ; SOLUTION: The process comprises reacting at a temperature <=130[deg.]C, (A) one or more NCO-functional compounds containing uretdione groups with (B) one or more compounds that contain isocyanate-reactive groups and radiation-curing groups and then (C) with one or more saturated hydroxy-containing compounds other than (B), at least one of these compounds having an OH functionality of >=2, in the presence of (D) a catalyst containing one or more zinc compounds, the reaction with compounds (C) taking place at least proportionally with the formation of allophanate groups. [less ▲]

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See detailRadiation-curing binders and a process for their preparation
Weikard, Jan; Detrembleur, Christophe ULg

Patent (2006)

A binder is prepared by reacting isocyanate-functional compound(s) containing uretdione groups; compounds that contain isocyanate-reactive groups and contain groups that react with ethylenically ... [more ▼]

A binder is prepared by reacting isocyanate-functional compound(s) containing uretdione groups; compounds that contain isocyanate-reactive groups and contain groups that react with ethylenically unsaturated compounds; saturated, hydroxyl-containing compound(s); and a catalyst containing ammonium salts or phosphonium salts of aliphatic or cycloaliphatic carboxylic acids. Preparation of a binder containing allophanate groups, groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and optionally isocyanate (NCO)-reactive groups, which comprises reacting at 130[deg]C NCO-functional compound(s) containing uretdione groups; compounds that contain isocyanate-reactive groups and contain groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups); saturated, hydroxyl-containing compound(s), at least one of these compounds having an OH functionality of 2; and a catalyst containing one or more ammonium salts or phosphonium salts of aliphatic or cycloaliphatic carboxylic acids, the reaction hydroxyl-containing compounds taking place at least proportionally with the formation of allophanate groups. An independent claim is also included for a coating composition comprising: (1) binders; (2) optionally polyisocyanate(s) which contain free or blocked isocyanate groups and optionally contain groups which react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation; (3) optionally compounds other than the polyisocyanate(s) which contain groups which react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation and optionally contain NCO-reactive groups; (4) optionally isocyanate-reactive compound(s) which are free from groups which react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation; and (5) initiators. [less ▲]

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See detailRadiation-curing binders and a process for their preparation
Weikard, Jan; Greszta-Franz, Dorota; Fischer, Wolfgang et al

Patent (2006)

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic ... [more ▼]

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups) and 3) optionally NCO-reactive groups, by reacting at temperatures <=130 DEG C. A) one or more NCO-functional compounds containing uretdione groups with B) one or more compounds that contain isocyanate-reactive groups and groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and then C) with one or more saturated, hydroxyl-containing compounds other than B), at least one of these compounds having an OH functionality of >=2, in the presence of D) a catalyst containing one or more zinc compounds, the reaction with compounds C) taking place at least proportionally with the formation of allophanate groups. The present invention also relates to the binders obtained by the process of the invention. [less ▲]

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See detailRadiation-induced malignant peripheral nerve sheat tumors – a report of 2 cases
PHAN BA, Remy ULg; BELACHEW, Shibeshih ULg; JEDIDI, Zayd ULg et al

Poster (2011, May)

We discuss the case of two patients who developped delayed malignant peripheral nerve sheath tumor (MPNST) following radiotherapy. Case report: the first patient is a sixty year-old woman with a 2 years ... [more ▼]

We discuss the case of two patients who developped delayed malignant peripheral nerve sheath tumor (MPNST) following radiotherapy. Case report: the first patient is a sixty year-old woman with a 2 years history of right cervicobrachial pain and weakness. The neurological examination depicted severe weakness, atrophy and loss of sensation in the right C5 and C6 territories. A subclavicular hardened and enlarged lymph node was noted. Her past medical history was notable for a Hodgkin’s disease (HD) treated with radiation therapy (>40Gy) 35 years earlier. Brachial plexus MRI revealed a tumoral mass arising from the right brachial plexus. Biopsy of the subclavicular mass revealed a poorly differentiated malignant tumour consisting of spindle cells showing moderate polymorphism and a high mitotic index. Immunohistochemistry showed positivity for the S-100 protein, the CD56 and for the epithelial membrane antigen (EMA) and a diagnosis of MPNST of the brachial plexus was proposed. The second case is a 36 year-old man referred for a history of right sciatic neuralgia that appeared 3 years earlier. The medical history of the patient was notable for a right seminoma, treated by orchidectomy and prophylactic radiotherapy (24 Gy) 5 years earlier. The neurologic examination revealed right L5 and S1 radicular territories involvement, and the CT of the pelvis demonstrated a nodular mass at the level of the greater sciatic foramen. A surgical biopsy was performed and the neuropathological findings were consistent with a diagnosis of low-grade MPSNT. Discussion: MPNSTs are rare tumors accounting for 3 to 10% of all tissues sarcomas. Half of the cases described are sporadic, while the other half tend to appear in patients suffering from tumor prone conditions, such as neurofibromatosis type 1. Although secondary neoplasms are known complications of radiotherapy, descriptions of peripheral nerve sheath tumors (PNST) are scarce. The exact pathophysiology of radiation-induced PNSTs remains unclear but vascular alterations, direct damages to axon or Schwann cell and nerve compression by soft tissue fibrosis are thought to play a role. Although surgical removal sometimes followed by chemotherapy is the mainstay of MPNSTs, they usually carry a poor prognosis. Our 2 cases emphasize that the possibility of radiation-induced MPNST has to be kept in mind when investigating a localized neuropathy in a previously irradiated area. [less ▲]

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See detailRadiation-Induced Myelopathy and Vertebral Necrosis
Martin, Didier ULg; Delacollette, Mireille ULg; Collignon, Jacques ULg et al

in Neuroradiology (1994), 36(5), 405-7

Radiation-induced myelopathy is often a diagnosis of exclusion. In addition to the classic criteria needed to support the diagnosis, the presence of another radiation-induced lesion, such as aseptic ... [more ▼]

Radiation-induced myelopathy is often a diagnosis of exclusion. In addition to the classic criteria needed to support the diagnosis, the presence of another radiation-induced lesion, such as aseptic vertebral necrosis, is useful to confirm the cause of the spinal cord lesion. [less ▲]

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See detailRadiations cométaires inexpliquées
Swings, Polydore ULg

in La physique des comètes : communications présentées au quatrième colloque international d’astrophysique (1952)

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See detailRadiative and Auger decay data for modeling nickel K lines
Palmeri, P; Quinet, Pascal ULg; Mendoza, C et al

in Astrophysical Journal. Supplement Series (2008), 179

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See detailRadiative and Auger decay of K-vacancy levels in the Ne, Mg, Si, S, Ar and Ca isonuclear sequences
Palmeri, P; Quinet, Pascal ULg; Mendoza, C et al

in Astrophysical Journal. Supplement Series (2008), 177

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