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See detailNew Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors
Francotte, Pierre ULg; Goffin, Eric ULg; Fraikin, Pierre ULg et al

in Journal of Medicinal Chemistry (2010), 53

In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive allosteric modulators of the AMPA receptors. In ... [more ▼]

In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive allosteric modulators of the AMPA receptors. In the present work, we focused our efforts on the insertion of mono- or polyfluoro- substituted alkyl chains at the 4-position of the thiadiazine ring in an attempt to enhance the pharmacokinetic behavior of previously described compounds. Among all the described compounds, 7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, 12b, was shown to exert a strong activity on AMPA receptors in vitro and a marked cognitive-enhancing effect in vivo after oral administration to Wistar rats. Considering its in vivo activity, the metabolic degradation of 12b was studied and compared to that of its nonfluorinated analogue 9b. Taken together, results of this study clearly validated the positive impact of the fluorine atom on the alkyl chain at the 4-position of benzothiadiazine dioxides on activity and metabolic stability. [less ▲]

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See detailNew fluorinated surfactant for nanogels preparation
Alaimo, David ULg; Rieger, Jutta; Beigbeder, Alexandre et al

Conference (2009, March 19)

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer ... [more ▼]

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer and used as stabilizers for the dispersion polymerization of 2-hydroxyethyl methacrylate (HEMA) in fluorinated solvent, namely alpha,alpha,alpha-trifluorotoluene (TFT). The effect of the amount and the architecture of the copolymer on the size and the stabilization of the particles was studied. Whatever the experimental conditions, scanning electron microscopy showed the formation of submicronic (typically about 300 nm) spherical particles, with a narrow size distribution. The principal difference emerges from the concentration of surfactant. Indeed, at higher copolymer concentration, smaller and less aggregated particles were produced. These results were confirmed by dynamic light scattering but these measurements also revealed the presence of larger aggregates (1,5 micrometer). Furthermore, the surfactant properties of the copolymers were investigated by measuring the interfacial tension at the H2O/TFT interface, and the results were correlated to their stabilizing efficiency in the dispersion polymerization of HEMA. [less ▲]

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See detailNew fluorinated surfactant for nanogels preparation in supercritical CO2
Alaimo, David ULg; Beigbeder, Alexandre; Dubois, Philippe et al

Poster (2011, April 29)

Detailed reference viewed: 39 (7 ULg)
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See detailNew fluorinated surfactants for nanogels preparation
Alaimo, David ULg; Rieger, Jutta; Beigbeder, Alexandre et al

Conference (2009, June 18)

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer ... [more ▼]

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer and used as stabilizers for the dispersion polymerization of 2-hydroxyethyl methacrylate (HEMA) in fluorinated solvent, namely alpha,alpha,alpha-trifluorotoluene (TFT). The effect of the amount and the architecture of the copolymer on the size and the stabilization of the particles was studied. Whatever the experimental conditions, scanning electron microscopy showed the formation of submicronic (typically about 300 nm) spherical particles, with a narrow size distribution. The principal difference emerges from the concentration of surfactant. Indeed, at higher copolymer concentration, smaller and less aggregated particles were produced. These results were confirmed by dynamic light scattering but these measurements also revealed the presence of larger aggregates (1,5 micrometer). Furthermore, the surfactant properties of the copolymers were investigated by measuring the interfacial tension at the H2O/TFT interface, and the results were correlated to their stabilizing efficiency in the dispersion polymerization of HEMA. [less ▲]

Detailed reference viewed: 43 (6 ULg)
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See detailNew fluorinated surfactants for nanogels preparation in supercritical CO2
Alaimo, David ULg; Beigbeder, Alexandre; Dubois, Philippe et al

Poster (2010, November 29)

Detailed reference viewed: 42 (7 ULg)
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See detailNew format of the quality of life systemic inventory for children (QLSI-C): preliminary results
Toucheque, Malorie ULg; Tilkin, Caroline; Etienne, Anne-Marie ULg

Poster (2013, July)

Background: This study assesses the test-retest reliability of the QLSI-C iPad version. Methods: Sample consisted of 40 children aged 8 to 12 years which completed QLSI-C twice over a two-week delay ... [more ▼]

Background: This study assesses the test-retest reliability of the QLSI-C iPad version. Methods: Sample consisted of 40 children aged 8 to 12 years which completed QLSI-C twice over a two-week delay. Participants were divided into 3 groups: 13 participants completed iPad (T0) – paper (T1) version, 13 others filled paper (T0) – iPad (T1) and 14 answered iPad (T0) – iPad (T1). Findings: Analysis of variance indicates that group effect (F(2,37) = 1,27, p = 0,29) and time effect (F(2,37) = 0,04, p= 0,84) is not statistically significant nor the interaction effect (F(2,37) = 0,08 p = 0,92). Correlations for the 5 global scores between iPad – iPad version is from .63 to .91 and between the 2 different formats is from .40 to .87. Discussion: QLSI-C test-retest stability and paper – iPad version equivalence are good. This new format is more attractive for children, decreases time for administration and makes easier the encoding. [less ▲]

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See detailA new formulation of internal forces for non-linear hypoelastic constitutive models verifying conservation laws
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Bathe, K. J. (Ed.) Second MIT Conference on Fluid and Solid Mechanics (2003)

This paper proposes a new formulation of the internal forces for hypoelastic constitutive models ensuring that the elastic work of deformation can be restored by the scheme. Moreover, we demonstrate that ... [more ▼]

This paper proposes a new formulation of the internal forces for hypoelastic constitutive models ensuring that the elastic work of deformation can be restored by the scheme. Moreover, we demonstrate that the work of the plastic deformation is positive and consistent with the material model. [less ▲]

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See detailA new formulation of state estimation in distribution systems including demand and generation states
Rousseaux, Patricia ULg; Toubeau, Jean-François; De Grève, Zacharie et al

in proceeedings of the 2015 Power Tech conference (2015, June)

Distribution system state estimation faces a major difficulty: the lack of real-time measurements. This imposes to add information, usually pseudo-measurements from historical data. This paper proposes a ... [more ▼]

Distribution system state estimation faces a major difficulty: the lack of real-time measurements. This imposes to add information, usually pseudo-measurements from historical data. This paper proposes a different, novel formulation of state estimation relying on the classification of loads into components (e.g. residential, commercial, etc.) and accounting for dispersed generation. The approach “by-passes” the use of pseudo-measurements by expressing the medium-voltage bus injections as functions of a small number of active power components at low-voltage level, treated as additional state variables. The injections at medium-voltage buses become equality constraints. A procedure to identify the above functions is detailed, which takes advantage of data collected by smart meters. [less ▲]

Detailed reference viewed: 89 (11 ULg)
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See detailNew fossils at the “Troisième caverne” of Goyet (Belgium) and the mortuary practices of late Neandertals
Rougier, H.; Crevecoeur, I.; Beauval, C. et al

Conference (2014, March 21)

Detailed reference viewed: 33 (0 ULg)
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See detailNew Functional Aliphatic Polyesters by Chemical Modification of Copolymers of ε-Caprolactone with γ-(2-Bromo-2-methylpropionate)- ε-caprolactone, γ-Bromo- ε-caprolactone, and a Mixture of β-and γ-Ene- ε-caprolactone
Detrembleur, Christophe ULg; Mazza, Michaël; Lou, Xudong et al

in Macromolecules (2000), 33(17), 7751-7760

New functional aliphatic polyesters were prepared by chemical modification of brominated copolyesters. Poly(epsilon-caprolactone)-co-poly(gamma-(2-bromo-2-methylpropionate)-epsilon-caprolactone) copolymer ... [more ▼]

New functional aliphatic polyesters were prepared by chemical modification of brominated copolyesters. Poly(epsilon-caprolactone)-co-poly(gamma-(2-bromo-2-methylpropionate)-epsilon-caprolactone) copolymer was prepared and successfully converted into copolyester bearing methacrylate double bonds by dehydrohalogenation of the pendant tertiary alkyl bromides, thus leading to cross-linkable polyester. The tertiary alkyl bromide groups of the original copolyester were also quaternized by reaction with pyridine, although some side reactions occurred which Limited the reaction yield. Nevertheless, quaternization of the bromide groups of the poly(epsilon-caprolactone)-co-poly(gamma-bromo-epsilon-caprolactone) copolymer proved to be quantitative and to occur without degradation of the polyester chains. This general strategy paves the way to either amphiphilic copolyesters or water-soluble polyesters. The poly(epsilon -caprolactone)-co-poly(gamma -bromo-epsilon-caprolactone) lactone) copolymer was also quantitatively converted into unsaturated copolyester by dehydrohalogenation with formation of double bonds including acrylic-type double bonds. As an alternative, gamma-bromo-epsilon-caprolactone was first dehydrohalogenated, and the unsaturated cyclic monomer was copolymerized with epsilon-caprolactone. Finally, the nonconjugated double bonds of the copolyesters were oxidized into epoxides, except for the acrylic-type unsaturations which remained unchanged. [less ▲]

Detailed reference viewed: 87 (12 ULg)
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See detailNew functional poly(N-vinylpyrrolidone) based (co)polymers via photoinitiated cobalt-mediated radical polymerization
Debuigne, Antoine ULg; Schoumacher, Matthieu ULg; Willet, Nicolas ULg et al

in Chemical Communications (2011), 47(47), 12703-12705

The photoinitiated cobalt-mediated radical polymerization enables the synthesis of novel alpha-functional and alpha,omega-telechelic polymers. In combination with ring-opening polymerization, it also ... [more ▼]

The photoinitiated cobalt-mediated radical polymerization enables the synthesis of novel alpha-functional and alpha,omega-telechelic polymers. In combination with ring-opening polymerization, it also produces new amphiphilic copolymers which self-assemble into flower-like vesicles in water. [less ▲]

Detailed reference viewed: 76 (15 ULg)
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See detailNew functional polyvinylacetate and polyvinylalcohol architectures
Detrembleur, Christophe ULg

Conference (2006, September 04)

Detailed reference viewed: 7 (0 ULg)
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See detailNew Functions of Stromal Proteases and Their Inhibitors in Tumor Progression
Noël, Agnès ULg; Albert, V.; Bajou, Khalid ULg et al

in Surgical Oncology Clinics of North America (2001), 10(2), 417-32

Acquisition of invasive metastatic potential through protease expression is a key event in tumor progression. In carcinomas, the production of metalloproteinases and serine proteinases is regulated by a ... [more ▼]

Acquisition of invasive metastatic potential through protease expression is a key event in tumor progression. In carcinomas, the production of metalloproteinases and serine proteinases is regulated by a cross talk between stromal cells and cancer cells. Paradoxically, high rather than low levels of their inhibitors predict poor survival of patients suffering from a variety of cancers. Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially. [less ▲]

Detailed reference viewed: 12 (5 ULg)
See detailA new FUV auroral feature on Jupiter
Grodent, Denis ULg; Gladstone, G. R.; Gérard, Jean-Claude ULg et al

Conference (2003, April 01)

In December 2000, a series of HST/STIS FUV images of Jupiter's north auroral region displayed bright transient spots located near local midnight. In the images taken at CML Ë 220[SUP]o[/SUP] the spots ... [more ▼]

In December 2000, a series of HST/STIS FUV images of Jupiter's north auroral region displayed bright transient spots located near local midnight. In the images taken at CML Ë 220[SUP]o[/SUP] the spots (one or two) appear near the limb, poleward and equatorward of the main auroral oval, at latitude Ë 73[SUP]o[/SUP] and λ[SUB]III[/SUB] longitude Ë 145[SUP]o[/SUP]. The dimensions of each spot are very small, about 1[SUP]o[/SUP] in latitude and 5[SUP]o[/SUP] in longitude, which is about the size of the footprint of the Io satellite. However, the analysis of the position of the Galilean satellites and of known small-bodies (comets, asteroids) shows that these spots are not magnetically associated with any of these objects. The emitted power of the spots is variable and can reach several GW (more than the power emitted at the Io footprint). The lightcurves derived from multiple images are consistent with spots disappearing behind the planetary limb as the planet rotates. In addition, one short time-tagged image undoubtedly shows a bright double--spot feature pulsating with a period of 300 s. According to the VIP4 magnetic model, the auroral spots map along field lines down to the jovian magnetosphere in a small region roughly located near midnight at distances larger than 60~R_J. At these distances, a 1[SUP]o[/SUP] by 5[SUP]o[/SUP] auroral spot subtends an equatorial region smaller than 10~R_J by 10~R_J . Consequently, the auroral spots cannot be directly associated with large scale process involving the whole magnetotail but rather with localized events. [less ▲]

Detailed reference viewed: 8 (3 ULg)
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See detailNew gamma-lactam homologs of penems
Marchand-Brynaert, Jacqueline; Couplet, Blandine; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry Letters (1993), 3(11), 2303-2308

Detailed reference viewed: 14 (2 ULg)
Peer Reviewed
See detailNew generation antiepileptics for facial pain and headache
DELVAUX, Valérie ULg; Schoenen, Jean ULg

in Acta Neurologica Belgica (2001), 101(1), 42-46

The prophylactic management of recurrent head and facial pains may be challenging because of lack of efficacy and/or bothersome adverse effects of available drug therapies. New generation antiepileptic ... [more ▼]

The prophylactic management of recurrent head and facial pains may be challenging because of lack of efficacy and/or bothersome adverse effects of available drug therapies. New generation antiepileptic drugs offer new perspectives in difficult cases. We will review the available published data and present our experience with lamotrigine in various head and facial pains such as migraine, cluster headache, neuropathic trigeminal pain, atypical facial pain, and chronic tension-type headache. Twenty-five patients were enrolled and followed for 18 months. The dose was gradually increased in steps of 25 mg up to the effective dose (mean 250 mg/d). Lamotrigine was most effective in trigeminal neuralgia and dysesthesia, but was of little utility in the other head or facial pains. [less ▲]

Detailed reference viewed: 17 (1 ULg)