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See detailPrognostic markers in malignant diseases
Chapelle, Jean-Paul ULg; Duvivier, J.; Gielen, J.

Conference (1995, July)

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See detailPrognostic markers in malignant diseases
Chapelle, Jean-Paul ULg; Duvivier, J.; Gielen, Jacques

in Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum (1995), 55

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See detailPrognostic significance of a low peak serum creatine kinase level in acute myocardial infarction
Pierard, Luc ULg; Dubois, Christophe ULg; Albert, Adelin ULg et al

in American Journal of Cardiology (1989), 63(12), 792-6

To assess the prognostic significance of a low peak creatine kinase (CK) level, 723 consecutive patients admitted with acute myocardial infarction (AMI) within 16 hours after onset of symptoms were ... [more ▼]

To assess the prognostic significance of a low peak creatine kinase (CK) level, 723 consecutive patients admitted with acute myocardial infarction (AMI) within 16 hours after onset of symptoms were studied. Thrombolytic therapy was not attempted during the study. Patients were dichotomized according to their peak CK levels, determined from a cluster analysis of peak CK distribution among the population of patients who died within 3 years after hospital discharge. The 139 patients with low peak CK (less than or equal to 650 IU/liter) (group 1) were compared to the 584 patients with high peak CK (greater than 650 IU/liter) (group 2). Patients in group 1 were older and had a higher incidence of previous AMI, angina pectoris before AMI and non-Q-wave AMI. Despite a lower incidence of in-hospital complications and a nonsignificantly lower hospital mortality rate (4 vs 9%) the group 1 three-year posthospital mortality rate was higher (26 vs 17%; p less than 0.02), especially in the subgroup of patients with a Q-wave infarct (mortality 31% in group 1 vs 16% in group 2; p less than 0.001). Among the 491 patients who had a first Q-wave AMI, 55 had a peak CK less than or equal to 650 IU/liter. Compared to the 436 patients with a higher peak CK, these 55 patients had a higher incidence of early postinfarction angina (31 vs 14%; p less than 0.01), a similar hospital mortality (4 vs 7%) but a higher 3-year posthospital mortality (23 vs 12%; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailPrognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas
Amara, Khaled; Trimeche, Mounir; Ziadi, Sonia et al

in Annals of Oncology (2008), 19(10), 1774-1786

Background: Diffuse large B-cell lymphoma (DLBCL) exhibits heterogeneous clinical features and a marked variable response to treatment. Patients and methods: We investigated the prognostic significance of ... [more ▼]

Background: Diffuse large B-cell lymphoma (DLBCL) exhibits heterogeneous clinical features and a marked variable response to treatment. Patients and methods: We investigated the prognostic significance of the methylation status of DAPK, GSTP1, P14, P15, P16, P33, RB1, SHP1, CDH1, APC, BLU, VHL, TIMP3, and RASSF1A genes in 46 DLBCL specimens from Tunisian patients. Methylation status of each gene was correlated with clinicopathological parameters including the International Prognostic Index (IPI), the germinal center immunophenotype, and response to treatment and survival. Overall survival (OS) and disease-free survival (DFS) rates were calculated by the Kaplan–Meier method and differences were compared with the log-rank test. Results: Hypermethylation of SHP1 was associated with elevated lactate dehydrogenase level (P = 0.031). P16 and VHL were frequently hypermethylated in patients with high IPI scores (P = 0.006 and 0.004) and a performance status of two or more (P = 0.007 and 0.047). In addition, hypermethylation of P16 was significantly associated with advanced clinical stages and B symptoms (P = 0.041 and 0.012). Interestingly, hypermethylation of DAPK was significantly correlated with resistance to treatment (P = 0.023). With regard to survival rates, promoter hypermethylation of DAPK, P16, and VHL were significantly associated with shortened OS (P = 0.003, 0.001, and 0.017, respectively) and DFS (P = 0.006, 0.003, and 0.046, respectively). In multivariate analysis, hypermethylation of DAPK remains an independent prognostic factor in predicting shortened OS (P = 0.001) and DFS (P = 0.024), as well as the IPI and the germinal center status. Conclusions: This study demonstrates that DLBCLs with hypermethylated P16, VHL, DAPK, and SHP1 commonly show a biologically aggressive phenotype and worse prognosis. Interestingly, hypermethylation of DAPK was found to be an independent prognostic factor that may be used in conjunction with the conventional prognostic factors such as the IPI and the germinal center status. [less ▲]

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See detailPrognostic Significance of bcl-2 Protein Expression in Aggressive Non-Hodkin's Lymphoma
Hermine, Olivier; Haioun, Corinne; Lepage, Eric et al

in Blood (1996)

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See detailPrognostic significance of electrocardiographic findings in angina at rest. Therapeutic implications.
Demoulin, J. C.; Bertholet, M.; Chevigne, M. et al

in British heart journal (1981), 46(3), 320-4

Ninety-five patients with angina at rest were observed in the coronary care unit. Eighty-one per cent presented concomitantly or had previously presented some other manifestations of coronary artery ... [more ▼]

Ninety-five patients with angina at rest were observed in the coronary care unit. Eighty-one per cent presented concomitantly or had previously presented some other manifestations of coronary artery disease. These patients were divided into two subgroups. In subgroup 1 (40 patients), episodes of non-exertional angina were associated with a pattern of hyperacute subepicardial injury and, frequently, with ventricular arrhythmias. In subgroup 2 (55 patients), the episodes of angina at rest were attended by horizontal ST depression, isolated T wave inversion, or trivial ST-T changes. Coronary angiographic findings were similar in both subgroups. Symptoms regressed in only 9% of patients in subgroup 1 while they were receiving beta-receptor antagonists, whereas amiodarone alone or amiodarone with nifedipine was successful in 58%. Of these patients, 25% developed a myocardial infarction shortly after admission. In subgroup 2 patients, beta-blockers were successful in 61%. Amiodarone isolated or associated with nifedipine was successful in 55% of the patients in whom it was tried. Only 5% of patients in this subgroup developed a myocardial infarction during their hospital stay. It is concluded that: (1) observation of the electrocardiogram during spontaneous angina in patients with known atherosclerotic coronary heart disease may be of prognostic significance and may influence therapeutic decision. (2) Amiodarone by virtue of its anginal and antiarrhythmic properties may be particularly useful in the treatment of non-exertional angina. [less ▲]

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See detailPrognostic significance of increased baseline plasma troponin I levels in PTCA patients
Chapelle, Jean-Paul ULg; Legrand, Victor ULg; Gielen, Jacques

in Clinical Chemistry (2000), 46(suppl), 82

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See detailThe prognostic significance of serum alpha 1-acid glycoprotein changes in acute myocardial infarction.
Chapelle, Jean-Paul ULg; Albert, Adelin ULg; Smeets, J. P. et al

in Clinica Chimica Acta (1981), 115(2), 199-209

Serum alpha 1-acid glycoprotein and haptoglobin concentrations were evaluated in 151 patients with acute myocardial infarction (MI) during the first ten days of hospitalization. Maximum glycoprotein ... [more ▼]

Serum alpha 1-acid glycoprotein and haptoglobin concentrations were evaluated in 151 patients with acute myocardial infarction (MI) during the first ten days of hospitalization. Maximum glycoprotein concentrations were found to be related to myoglobin and enzyme peak levels. Glycoprotein levels recorded upon patients' admission did not vary for acute phase survivors and early deaths (15 patients), but the latter demonstrated significantly higher alpha 1-acid glycoprotein levels (p less than 0.05) on day 1. The maximum glycoprotein concentrations were, however, reached too long after the onset of acute MI to be of interest for short-term prognosis. Comparison of the evolution of the two glycoproteins investigated in late deaths (10 patients) and in 6-month survivors indicated increased alpha 1-acid glycoprotein levels in non-survivors, with a maximum discrimination occurring on day 8 (p less than 0.001). Haptoglobin was not significantly different in the two groups and even demonstrated lower concentrations from day 4 to day 10 in non-survivors. The decrease of haptoglobin levels in patients with hepatic dysfunction could explain the divergent results given by the serum concentrations of the two glycoproteins to predict mortality. We show in this study that alpha 1-acid glycoprotein measured at the end of hospitalization can give relevant prognostic information for the 6-month period following acute MI. [less ▲]

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See detailPROGNOSTIC VALUE OF AMPS METHOD IN ALS PATIENTS
WANG, François-Charles ULg; GERARD, Pascale ULg; BOUQUIAUX, Olivier ULg et al

in Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders (2005)

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See detailPrognostic Value of Aortic Stiffness and Calcification for Cardiovascular Events and Mortality in Dialysis Patients: Outcome of the Calcification Outcome in Renal Disease (CORD) Study
Verbeke, Francis; Van Biesen, Wim; Honkanen, Eero et al

in Clinical Journal of the American Society of Nephrology (2011), 6

Background and objectives: Radiographic calcification and arterial stiffness each individually are predictive of outcome in dialysis patients. However, it is unknown whether combined assessment of these ... [more ▼]

Background and objectives: Radiographic calcification and arterial stiffness each individually are predictive of outcome in dialysis patients. However, it is unknown whether combined assessment of these intermediate endpoints also provides additional predictive value: Design, setting, participants & measurements: Scoring of abdominal aortic calcification (AAC) using plain lateral abdominal x-ray and measurement of carotid-femoral pulse wave velocity (PWV) were performed in a cohort of 1084 prevalent dialysis patients recruited from 47 European dialysis centers. Results: During a follow-up of 2 years, 234 deaths and 91 nonfatal cardiovascular (CV) events occured. Compared with the lowest tertile of AAC, the risk of an event was increased by a factor 3.7 in patients wih a score of 5 to 15 (middle tertile), and by a factor 8.6 in patients with scores of 16 to 24. Additionally, each 1-m/s increase in PWV was associated with a 15% higer risk. At higher AAC (scores >= 5), the effect of PWV was attenuated because of a negative PWV X AAC interaction (hazard ratio [HR]:0.895 and 0.865 for middle and upper AAC tertiles). After accounting for age, diabetes, and serum albumin, AAC and PWV remained independent predictors of outcome. Conclusions: AAC and central arterial stiffness are independent predictors of mortality and nonfatal CV events in dialysis patients. The risk associated with an increased PWV is less pronounced at higher levels of calcification. Assessment of AAC and PWV is feasible in a clinical setting and both may be used or an accurate CV risk estimation in this heterogeneous population. [less ▲]

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See detailPrognostic Value of Bone Sialoprotein Expression in Clinically Localized Human Prostate Cancer
Waltregny, David ULg; Bellahcene, Akeila ULg; Van Riet, Ivan et al

in Journal of the National Cancer Institute (1998), 90(13), 1000-8

BACKGROUND: Bone sialoprotein (BSP), a bone matrix protein, was recently found to be expressed ectopically in breast cancer and to have a statistically significant association with poor prognosis and the ... [more ▼]

BACKGROUND: Bone sialoprotein (BSP), a bone matrix protein, was recently found to be expressed ectopically in breast cancer and to have a statistically significant association with poor prognosis and the development of bone metastases in that disease. These data prompted us to investigate whether BSP might also be expressed in human prostate cancer, which often metastasizes to bone, and be predictive for progression risk. METHODS: Tissue sections from 180 patients who had undergone a radical prostatectomy for localized prostate cancer were analyzed immunohistochemically for BSP expression. Biochemical progression was defined as an increasing serum prostate-specific antigen level of 0.5 ng/mL or more. Statistical analysis was used to assess associations between pathologic findings and level of BSP expression, and a Cox proportional hazards model was used to determine which clinical and histologic parameters, including stage, Gleason score, and BSP expression (immunostaining intensity and extent), were independently associated with biochemical progression. All P values were two-sided. RESULTS: Most of the prostate cancer lesions examined (78.9%) expressed detectable levels of BSP, compared with no or low expression in the adjacent normal glandular tissue. A statistically significant association was found between BSP expression and biochemical progression in both univariate and multivariate analyses. After a follow-up interval of 3 years, the biochemical relapse rate was 36.7% (95% confidence interval [CI] = 23.4%-47.7%) in patients whose tumors expressed high levels of BSP compared with 12.1% (95% CI = 2.3%-20.8%) in patients whose tumors expressed no or a low detectable level of the protein (logrank test, P = .0014). BSP expression status could identify those patients at higher risk of biochemical progression (logrank test, P<.05) among patients with moderately differentiated tumors or with pathologically confined tumors. CONCLUSIONS: To our knowledge, this study is the first to demonstrate BSP expression in human prostate cancer and to highlight the protein's statistically significant prognostic value in patients with clinically confined prostate adenocarcinomas. [less ▲]

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See detailPrognostic value of clinical signs and blood parameters in equids suffering from acute hepatic insufficiency: a retrospective study on 31 cases
Amory, Hélène ULg; Perron, MF; Sandersen, Charlotte ULg et al

in Proceedings of the 21st ACVIM annual meeting, Charlotte, North Carolina (2003)

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See detailPrognostic value of clinical signs and blood parameters in equids suffering from hepatic diseases
Amory, Hélène ULg; Perron, M. F.; Sandersen, Charlotte ULg et al

in Journal of Equine Veterinary Science (2005), 25(1), 18-25

The purpose of this retrospective study was to further identify in the equine species the clinical signs and blood parameters that could be useful to identify a hepatic disease and act as predictors of ... [more ▼]

The purpose of this retrospective study was to further identify in the equine species the clinical signs and blood parameters that could be useful to identify a hepatic disease and act as predictors of the outcome in animals suffering from an acute hepatic insufficiency. The study included 31 equids that were hospitalized at the University of Liege and that suffered from a hepatic (group 1, 17 cases of hepatitis; group 2, 11 cases of hyperlipemia) or post-hepatic (group 3, 3 cases of cholelithiasis) disease. Frequency of the clinical signs and values of selected blood parameters on admission were compared statistically between surviving and non-surviving animals. The most frequently presented clinical signs were depression, decreased appetite or anorexia, fever, tachycardia, polypnea, icterus, and congested mucous membranes. Frequency of the clinical signs and blood parameter values were not statistically different in surviving and non-surviving animals, with the exception of gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP), which were significantly higher in animals with fatal outcome, with a cutoff value of 224 and 820 IU/L, respectively. [less ▲]

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See detailprognostic value of combined data on enzymes and inflammation markers in plasma in cases of severe head injury
Bourguignat, A.; Albert, Adelin ULg; Férard, G. et al

in Clinical Chemistry (1983), 29

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