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See detailPustulose exanthématique aiguë généralisée due à un agent de contraste iodé pour radiodiagnostic.
Paquet, Philippe ULg; Vandenbossche, Géraldine; Nikkels, Arjen ULg et al

in Revue Médicale de Liège (2009), 64

Iodinated contrast agents are frequently involved in delayed polymorphic adverse skin reactions. Acute generalized exanthematous pustulosis following administration of iodinated contrast agents is a rare ... [more ▼]

Iodinated contrast agents are frequently involved in delayed polymorphic adverse skin reactions. Acute generalized exanthematous pustulosis following administration of iodinated contrast agents is a rare but severe form of such reactions. The disease is characterized by the sudden occurrence of an erosive and pustular erythroderma with fever, leukocytosis and sometimes peripheral adenopathies and liver involvement. This condition is considered as an immunologic reaction, primarily involving T lymphocytes. The overall mortality reaches about 1%. Elucidating the differential diagnosis with other acute paroxysmal drug eruptions (toxic epidermal necrolysis, Steven-Johnson syndrome and drug hypersensitivity syndrome) is of paramount importance for establishing the adequate treatment of PEAG. [less ▲]

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See detailLa pustulose sous-cornee de Sneddon et Wilkinson.
Martalo, O.; Paquet, Philippe ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(10), 628-30

The subcorneal pustular dermatosis of Sneddon and Wilkinson belongs to the heterogeneous group of neutrophilic dermatosis. This unique disorder is characterized by a superficial pustular eruption. The ... [more ▼]

The subcorneal pustular dermatosis of Sneddon and Wilkinson belongs to the heterogeneous group of neutrophilic dermatosis. This unique disorder is characterized by a superficial pustular eruption. The pustules are flaccid and aseptic. They develop predominantly on the trunk and in the groins, axillae and submammary areas. This disease is benign and chronic. However, it can be associated with some other conditions such as lymphoproliferative and myeloproliferative diseases. Dapsone is the treatment of choice to control the skin manifestations. [less ▲]

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See detail"Putain" de Nelly Aran, une écriture scandaleusement intime
Hick, Anne-Laure ULg

in Bertrand, Jean-Pierre; Frederic, Madeleine; den Toonder, Jeanette (Eds.) Écritures de l’intime dans la littérature francophone du Canada (1980-2005) (in press)

Récit, roman, autofiction, autobiographie, roman autobiographique… qu’il s’agisse des éditeurs, des critiques, du monde universitaire ou de l’auteur elle-même, personne ne s’accorde lorsqu’il s’agit de ... [more ▼]

Récit, roman, autofiction, autobiographie, roman autobiographique… qu’il s’agisse des éditeurs, des critiques, du monde universitaire ou de l’auteur elle-même, personne ne s’accorde lorsqu’il s’agit de qualifier Putain (2001) de Nelly Arcan. En effet, au-delà du scandale thématique de l’œuvre, le mécanisme énonciatif de celle-ci est très particulier. Il s’agira dans cet article de montrer comment l’écriture de ce récit intime fuit tout classement selon les règles des genres autobiographiques, tout en exploitant celles-ci de façon tout à fait originale – et donc scandaleuse. [less ▲]

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See detailPutative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes
Smargiasso, Nicolas ULg; Gabelica, Valérie ULg; Damblon, Christian ULg et al

in BMC Genomics (2009), 10

Background. Guanine-rich nucleic acid sequences are capable of folding into an intramolecular four-stranded structure called a G-quadruplex. When found in gene promoter regions, G-quadruplexes can ... [more ▼]

Background. Guanine-rich nucleic acid sequences are capable of folding into an intramolecular four-stranded structure called a G-quadruplex. When found in gene promoter regions, G-quadruplexes can downregulate gene expression, possibly by blocking the transcriptional machinery. Here we have used a genome-wide bioinformatic approach to identify Putative G-Quadruplex Sequences (PQS) in the Plasmodium falciparum genome, along with biophysical techniques to examine the physiological stability of P. falciparum PQS in vitro. Results. We identified 63 PQS in the non-telomeric regions of the P. falciparum clone 3D7. Interestingly, 16 of these PQS occurred in the upstream region of a subset of the P. falciparum var genes (group B var genes). The var gene family encodes PfEMP1, the parasite’s major variant antigen and adhesin expressed at the surface of infected erythrocytes, that plays a key role in malaria pathogenesis and immune evasion. The ability of the PQS found in the upstream regions of group B var genes (UpsB-Q) to form stable Gquadruplex structures in vitro was confirmed using 1H NMR, circular dichroism, UV spectroscopy, and thermal denaturation experiments. Moreover, the synthetic compound BOQ1 that shows a higher affinity for DNA forming quadruplex rather than duplex structures was found to bind with high affinity to the UpsB-Q. Conclusions. This is the first demonstration of non-telomeric PQS in the genome of P. falciparum that form stable G-quadruplexes under physiological conditions in vitro. These results allow the generation of a novel hypothesis that the G-quadruplex sequences in the upstream regions of var genes have the potential to play a role in the transcriptional control of this major virulence-associated multi-gene family. [less ▲]

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See detailPutative glacial refugia of Cedrus atlantica deduced from Quaternary pollen records and modern genetic diversity
Cheddadi, R.; Fady, B.; François, Louis ULg et al

in Journal of Biogeography (2009), 36(7), 1361-1371

Aim To investigate the impact of past environmental changes on Cedrus atlantica and its current genetic diversity, and to predict its future distribution. Location Morocco, Algeria and Tunisia. Methods ... [more ▼]

Aim To investigate the impact of past environmental changes on Cedrus atlantica and its current genetic diversity, and to predict its future distribution. Location Morocco, Algeria and Tunisia. Methods Eleven fossil pollen records from these three countries were used to locate putative glacial refugia and to reconstruct past climate changes. A mechanistic vegetation distribution model was used to simulate the distribution of C. atlantica in the year 2100. In addition, a genetic survey was carried out on modern Moroccan C. atlantica. Results Pollen records indicate that Cedrus was present during the last glacial period, probably in scattered refugia, in Tunisia, Algeria and Morocco. In the Tunisian and Algerian sites, cedar expanded during the late glacial and the early Holocene, then disappeared after c. 8000 yr bp. Reconstructed mean annual precipitation and January temperature show that the last glacial period in Morocco was cooler by 10-15 degrees C and drier by c. 300-400 mm year(-1) than the climate today. Modern chloroplast microsatellites of 15 C. atlantica populations in Morocco confirm the presence of multiple refugia and indicate that cedar recolonized the Moroccan mountains fairly recently. Model simulation indicates that by the year 2100 the potential distribution of C. atlantica will be much restricted with a potential survival area located in the High Atlas. Main conclusions Environmental changes in northern Africa since the last glacial period have had an impact on the geographical distribution of C. atlantica and on its modern genetic diversity. It is possible that by the end of this century C. atlantica may be unable to survive in its present-day locations. To preserve the species, we suggest that seedlings from modern C. atlantica populations located in the High Atlas mountains, where a high genetic diversity is found, be transplanted into the western High Atlas. [less ▲]

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See detailPutative implication of equine herpesvirus in lower airway inflammation: systematic PCR assays of 708 respiratory fluids
Fortier, Guillaume ULg; Richard, Eric ULg; Pronost, S. et al

in Tessier, Caroline; Gerber, Vincent (Eds.) Abstract book: 4th World Equine Airways Symposium (WEAS) (2009)

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See detailPutative roles of the CNF2 and CDTIII toxins in experimental infections with necrotoxigenic Escherichia coli type 2 (NTEC2) strains in calves
Van Bost, S.; Roels, S.; Oswald, E. et al

in Microbes & Infection (2003), 5(13), 1189-1193

Newborn colostrum-restricted calves were orally inoculated with an Escherichia coli strain, identified originally as non-pathogenic, and into which the plasmid pVir was conjugally transferred. This ... [more ▼]

Newborn colostrum-restricted calves were orally inoculated with an Escherichia coli strain, identified originally as non-pathogenic, and into which the plasmid pVir was conjugally transferred. This resulted in diarrhea, intestinal lesions and extra-intestinal invasion, suggesting that factors affecting these pathogenic properties are located on pVir. In order to analyze the respective roles of the toxins CNF2 and CDTIII in the pathogenesis, colostrum-restricted calves were inoculated with isogenic mutants in the cnf2 and the cdt-III genes. The loss of cnf2 is associated with a reduction in the pathogenicity, since diarrhea does not occur in calves challenged, in spite of successful colonization of the intestine. Nevertheless, the mutant strain remains able to invade the bloodstream and to localize in the internal organs. Conversely, the calves inoculated with mutant in the cdt-III gene evolved in the same way as wild-type strain-inoculated calves with regard to clinical signs and macroscopic or microscopic lesions. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved. [less ▲]

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See detailPutois, écureuil, hérisson, loir
Libois, Roland ULg

Learning material (1992)

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See detailPutrescine metabolism in a fully habituated nonorganogenic sugar beet callus and its relationship with growth
Kevers, Claire ULg; Bisbis, Badia; Faivre-Rampant, Odile et al

in Journal of Plant Physiology (1999), 154(4), 503-508

A fully-habituated and nonorganogenic (HNO) sugar beet callus was previously shown to overproduce polyamines, as compared with a normal (N) auxin- and cytokinin-dependent callus of the same strain ... [more ▼]

A fully-habituated and nonorganogenic (HNO) sugar beet callus was previously shown to overproduce polyamines, as compared with a normal (N) auxin- and cytokinin-dependent callus of the same strain. Because relationships were established between polyamine levels and metabolism with different growth and development processes, some key enzymes in the metabolic pathways of polyamines were investigated in the HNO callus, and their involvement in growth appraised. Putrescine was found to be the major free and conjugated polyamine in the HNO callus. It was biosynthesised preferentially via ornithine and ornithine decarboxylase (ODC), which is in agreement with the surplus of synthesised ornithine. Diamine (DAO) and polyamine (PAO)-oxidase activities were also highest in the HNO callus, as compared with the normal, with DAO being the more active. Transglutaminase activities (+/- Ca) were also higher in HNO than in normal callus. Addition of different polyamines or of inhibitors of their biosynthesis to the culture medium of the HNO callus modified the level of endogenous polyamines and affected callus growth. The results thus pointed out a higher polyamine metabolism, particularly of putrescine, in the actively growing auxin- and cytokinin-independent callus than in the normal one. They also provided evidence for the sensitivity of a habituated tissue type towards this class of growth regulators. [less ▲]

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See detailPutting Prebiotics in their Place. On Europe's Intestinal Flora
Hendrickx, Kim ULg

Scientific conference (2012, January 18)

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See detailPuzzling locations of mildly metal-poor stars in the HR diagram
Jehin, Emmanuel ULg; Noels-Grötsch, Arlette ULg; Magain, Pierre ULg et al

in Noels-Grötsch, Arlette; Magain, Pierre; Caro, Denise (Eds.) et al Liege International Astrophysical Colloquia (2000)

Not Available

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See detailThe puzzling Luminous Blue Variable-like object HD 5980 in the Small Magellanic Cloud.
Heydari-Malayeri, M.; Rauw, Grégor ULg; Esslinger, O. et al

in Astronomy and Astrophysics (1997), 322

We have observed the exceptional SMC star HD 5980 during several runs from 1989 to 1995 at ESO La Silla. CASPEC at the 3.6m telescope and EMMI in echelle and long slit modes at NTT were used for ... [more ▼]

We have observed the exceptional SMC star HD 5980 during several runs from 1989 to 1995 at ESO La Silla. CASPEC at the 3.6m telescope and EMMI in echelle and long slit modes at NTT were used for spectroscopy. Sub-arcsecond images were obtained using SUSI at NTT and also an adaptive optics system at the 3.6m telescope. In all our spectra taken before 1994 September HD 5980 shows a spectral type of WN6. The 1994 September spectra were taken shortly after the maximum of the visual light-curve of the LBV-like phenomenon (Bateson & Jones, 1993PVSS...19...50B) and about one month before the observations of Barba et al. (1995ApJ...446L..23B). Near maximum visual brightness, HD 5980 displays a WN11-like spectrum with the HeI lines and the Balmer lines Hdelta and Hgamma showing well-developed PCyg profiles. The sub-arcsecond images (0.17" FWHM), through the near infrared bands J, H, and K, obtained in 1993 and 1996, show no stellar components down to 6.7 mag fainter than HD 5980 in K at a separation of 1.0" and the 3sigma level. For a separation of 0.3" this upper bound is 4.1mag fainter than HD 5980. The observed behavior of this object raises serious problems for our comprehension of the LBV phenomenon in the conventional scenarios of massive star evolution. The present observations cover a crucial period in the evolution of HD 5980 and will therefore be helpful for better understanding this peculiar object especially during its outburst as well as the evolution of W-R stars in general. [less ▲]

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See detailThe puzzling new class of variable stars in NGC 3766 : old friend pulsators?
Salmon, Sébastien ULg; Montalban Iglesias, Josefa ULg; Reese, Daniel et al

in Astronomy and Astrophysics (2014)

The recent variability survey of the NGC 3766 cluster revealed a considerable number of periodic variable stars in a region of the H-R diagram where no pulsation is expected. This region lies between the ... [more ▼]

The recent variability survey of the NGC 3766 cluster revealed a considerable number of periodic variable stars in a region of the H-R diagram where no pulsation is expected. This region lies between the instability strips of the delta Scuti and SPB stars. Moreover the periods of the new phenomenon, P~0.1-0.7 d, do not allow to associate it a priori to either of these two types of pulsations. Stars in the NGC 3766 cluster are known as fast rotators with rotational velocities typically larger than half of their critical velocity. Rotation can affect both the geometrical properties and period domain of pulsations. It also alters the apparent stellar luminosity through gravity darkening, effect seldom taken considered in theoretical studies of the rotation-pulsation interaction. We explore if both of these effects are able to deliver a consistent interpretation for the observed properties of the "new variables" in NGC 3766: explaining their presence outside the known instability strips and their variability periods. We carry out an instability analysis of SPB models within the framework of the Traditional Approximation of Rotation and study the visibility of modes according to the angle of view and rotation. We also check how gravity darkening affects the effective temperature and luminosity of stellar models for different angles of view and rotation velocities. At the red (cold) border of the instability strip, prograde sectoral modes are preferentially excited and their visibilities are maximum when seen equator-on. Furthermore low-mass SPB models seen equator-on can appear in the gap between non-rotating SPB and delta Scuti stars due to gravity darkening. In that case, periods of these most visible modes are shifted to the 0.2-0.5 d range due to the effects of the Coriolis force. We hence suggest that the new variable stars observed in NGC 3766 are actually fast rotating SPB pulsators. [less ▲]

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See detailPyelonephrite xanthogranulomateuse pseudotumorale: diagnostic par la biopsie percutanee et succes du traitement conservateur
Reul, Olivier ULg; Waltregny, David ULg; Boverie, Jacques ULg et al

in Progrès en Urologie (2001), 11(6), 1274-6

Focal xanthogranulomatous pyelonephritis is an unusual form of chronic renal infection that is difficult to diagnose prior to surgery. We report on a 19-year-old woman who presented with a renal mass that ... [more ▼]

Focal xanthogranulomatous pyelonephritis is an unusual form of chronic renal infection that is difficult to diagnose prior to surgery. We report on a 19-year-old woman who presented with a renal mass that mimicked malignancy. The diagnosis of focal xanthogranulomatous pyelonephritis was first suspected by radiological findings and further confirmed by histopathologic examination of percutaneous biopsy specimens of the lesion. Successful treatment of the patient was achieved with antibiotic therapy alone. Maximal efforts, including percutaneous renal biopsy, should be made to establish the diagnosis of focal xanthogranulomatous pyelonephritis before a therapeutic decision is reached. We recommend the use of antibiotics as a first-line treatment for patients with focal xanthogranulomatous pyelonephritis. [less ▲]

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See detailLa pyknocytose infantile : une anemie neonatale mal connue a propos de 5cas.
Limme, Boris ULg; Dresse, Marie-Françoise ULg; Ketelslegers, O. et al

in Archives de Pédiatrie (2008), 15(12), 1765-8

Infantile pyknocytosis (IP) is a rare hematological entity of newborns. It is a form of hemolytic anemia with unusual red cell morphology: the red blood cells are distorted, irregular, and small with many ... [more ▼]

Infantile pyknocytosis (IP) is a rare hematological entity of newborns. It is a form of hemolytic anemia with unusual red cell morphology: the red blood cells are distorted, irregular, and small with many projections. Spontaneous resolution usually occurs by 4-6months of age. OBSERVATION: We describe the clinical features and biological parameters of 5 cases of IP. The first symptoms were always early jaundice, which required phototherapy. Anemia was severe in all babies and red blood cell transfusion was needed. CONCLUSION: IP is a rare cause of neonatal anemia whose diagnosis is based on a careful peripheral blood smear examination. In our study, anemia was severe and required red blood cell transfusion. Ethnic specificity and familial occurrence are reported in our experience. [less ▲]

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See detailPylephlebitis of the portal vein complicating intragastric migration of an adjustable gastric band
De Roover, Arnaud ULg; Detry, Olivier ULg; Coimbra Marques, Carla ULg et al

in Obesity Surgery (2006), 16(3), 369-371

Pylephlebitis, or septic thrombophlebitis of the portal vein, is an infrequent but life-threatening complication of abdominal septic events. The authors report the occurrence of pylephlebitis and multiple ... [more ▼]

Pylephlebitis, or septic thrombophlebitis of the portal vein, is an infrequent but life-threatening complication of abdominal septic events. The authors report the occurrence of pylephlebitis and multiple liver abscesses induced by a neglected intra-gastric migration of an adjustable silicone gastric band. The patient was successfully treated by broad-spectrum antibiotics and total gastrectomy with Roux-en-Y esophagojejunostomy. Postoperative recovery was marked by acute liver failure that was managed conservatively. The patient is alive and well at 1-year follow-up. This case emphasizes the interest in early removal of the band when intra-gastric migration is diagnosed. [less ▲]

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See detailPyovagina caused by pyometra and a persistent hymen in a 9-year-old bitch
Van Den Berghe, Femke ULg; Ponthier, Jérôme ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (2013, September), 48(suppl1), 114

Pyovagina with a persistent hymen is very uncommon in a 9-year-old intact bitch. Blood discharge during prooestrus phases of previous cycles and the recent purulent vulvar discharge indicate an -at least ... [more ▼]

Pyovagina with a persistent hymen is very uncommon in a 9-year-old intact bitch. Blood discharge during prooestrus phases of previous cycles and the recent purulent vulvar discharge indicate an -at least partially- perforated hymen. For an unknown cause the hymen must have re-sealed after uterine contamination explaining a pyovagina that was bulging in the perineal area [less ▲]

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See detailThe Pyoverdin Of Pseudomonas Fluorescens Btp2, A Novel Structural Type
Ongena, MARC ULg; Jacques, P.; Thonart, Philippe ULg et al

in Tetrahedron Letters (2001), 42(34),

Abstract—From Pseudomonas fluorescens BTP2 a pyoverdin was isolated which contained the so far not encountered Val in its peptide chain. Its structure could be elucidated by chemical degradation and ... [more ▼]

Abstract—From Pseudomonas fluorescens BTP2 a pyoverdin was isolated which contained the so far not encountered Val in its peptide chain. Its structure could be elucidated by chemical degradation and spectroscopic data. [less ▲]

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