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See detailReliable low cost capillary electrophoresis device for drug quality control and counterfeit medicines
Marini Djang'Eing'A, Roland ULg; Rozet, Eric ULg; Montes De Lourdes Aja, Maria et al

in Journal of Pharmaceutical & Biomedical Analysis (2010), 53(5), 1278-1287

The proportion of counterfeit medicines is dramatically increasing these last few years. According to numerous official sources, in some pharmaceutical wholesalers in African countries, the proportion has ... [more ▼]

The proportion of counterfeit medicines is dramatically increasing these last few years. According to numerous official sources, in some pharmaceutical wholesalers in African countries, the proportion has reached 80%. Unfortunately, this situation is far to be improved due to lack of suitable analytical equipment allowing rapid actions of the Regulatory Agencies based on scientific consideration, at affordable cost and all over the drug supply chain. For that purpose, a network group considered that mater by building a low-cost original capillary electrophoresis (CE) equipment equipped with a new deep UV detector based on LED technology. The generic conditions for analysis were investigated: capillary zone electrophoresis (CZE) performed at acidic pH for basic drug molecules (i.e., quinine, highly used as the last antimalarial rampart), basic pH for compounds such as furosemide (a common diuretic drug) and at neutral pH for a well known antibiotic combination, trimethoprim/sulfamethoxazol. To evaluate the ability of the CE equipment for quantification, a full validation and a method comparison study were carried out for the CZE method dedicated to quinine determination. The validation involved the use of accuracy profile and total error concept to monitor the adequacy of the results obtained by the new prototype. The method comparison was based on the Bland and Altman approach by comparing results obtained by the low-cost CE and a conventional set-up. Subsequent validation studies were realized with neutral and acidic drug molecules, each focusing on a single concentration level calibration curve in order to maintain as low as possible the expenses due to reagents and thus the cost of analysis, as important advantages of CE for drug quality control. [less ▲]

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See detailReliable simulation of mechatronic systems using Newmark algorithms
Bruls, Olivier ULg; Duysinx, Pierre ULg; Golinval, Jean-Claude ULg

Conference (2004, March)

In the framework of flexible multibody systems simulation, the stability and the accuracy of the time integration process can be guaranteed by a family of implicit integrators derived from the Newmark ... [more ▼]

In the framework of flexible multibody systems simulation, the stability and the accuracy of the time integration process can be guaranteed by a family of implicit integrators derived from the Newmark scheme (Hilber-Hughes-Taylor and Generalized- methods). This paper deals with the extension of those reliable integrators for the simulation of mechatronic systems. In order to account for the strong coupling between the mechanism and the control system, the coupled set of equations contains mechanical and control variables. The generation of those equations, their numerical treatment and their time integration may become unmanageable for realistic control systems. In many cases, it is however sufficient to consider a weak coupling, which means that the action of the control system is treated as an external force disturbing the dynamic equilibrium. The weak coupling assumption is fully justified when a digital controller is present in the control loop. Then, the control actions exhibit discontinuous transitions at each sampling instant. The standard form of the Newmark scheme assumes continuity of the acceleration variables, and is thus not appropriate for this situation. Therefore, we propose an adapted Newmark scheme which achieves an explicit treatment of the acceleration jumps throughout the integration process, so that the proper simulation of the mechatronic system is guaranteed. The paper describes the detailed modifications of the integration algorithm. Illustrative examples are used to point out the critical situations where they prevent from substantial integration errors. [less ▲]

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See detailRelics of the saints - Recent publications and new perspectives
George, Philippe ULg

Book published by Revue Belge Philologie Histoir (2002)

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See detailA relict bank vole lineage highlights the biogeographic history of the Pyrenean region in Europe
Deffontaine Deurbroeck, Valérie ULg; Ledevin, Ronan; Fontaine, Michaël ULg et al

in Molecular Ecology (2009)

The Pyrenean region exhibits high levels of endemism suggesting a major contribution to the phylogeography of European species. But, to date, the role of the Pyrenees and surrounding areas as a glacial ... [more ▼]

The Pyrenean region exhibits high levels of endemism suggesting a major contribution to the phylogeography of European species. But, to date, the role of the Pyrenees and surrounding areas as a glacial refugium for temperate species remains poorly explored. In the current study, we investigated the biogeographic role of the Pyrenean region through the analyses of genetic polymorphism and morphology of a typical forest-dwelling small mammal, the bank vole (Myodes glareolus). Analyses of the mitochondrial cytochrome b gene and the third upper molar (M(3)) show a complex phylogeographic structure in the Pyrenean region with at least three distinct lineages: the Western European, Spanish and Basque lineages. The Basque lineage in the northwestern (NW) Pyrenees was identified as a new clearly differentiated and geographically localized bank vole lineage in Europe. The average M(3) shape of Basque bank voles suggests morphological differentiation but also restricted genetic exchanges with other populations. Our genetic and morphological results as well as palaeo-environmental and fossils records support the hypothesis of a new glacial refugium in Europe situated in the NW Pyrenees. The permissive microclimatic conditions that prevailed for a long time in this region may have allowed the survival of temperate species, including humans. Moreover, local differentiation around the Pyrenees is favoured by the opportunity for populations to track the shift of the vegetation belt in altitude rather than in latitude. The finding of the Basque lineage is in agreement with the high level of endemic taxa reported in the NW Pyrenees. [less ▲]

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See detailA relict sedimentary record of 7 earthquakes between 600AD and 2000BC on the central North Anatolian Fault at Elmacik, near Osmancik, Turkey
Fraser, J.G.; Vanneste, K.; Hubert, Aurelia ULg

in Geophysical Research Abstracts (2009, April)

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See detailA relict sedimentary record of seven earthquakes between 600 AD and 2000 BC on the central North Anatolian Fault at Elmacik, near Osmancik, Turkey
Fraser, J.; Hubert, Aurelia ULg; Vanneste, K. et al

in Geological Society of America Bulletin (2010), 122(11-12), 1830-1845

Deformation along the northern edge of the westward-moving Anatolian plate is concentrated along the North Anatolian fault. This northward-arching fault extends from the Karliova triple junction in the ... [more ▼]

Deformation along the northern edge of the westward-moving Anatolian plate is concentrated along the North Anatolian fault. This northward-arching fault extends from the Karliova triple junction in the east, ∼1500 km into the Aegean Sea in the west. A sequence of twentieth-century earthquakes ruptured the fault, displaying a spatiotemporal pattern consistent with a stress triggering mechanism. In 1943, the Mw 7.6 Tosya earthquake ruptured a 280-km-long segment near the center of the fault. Four paleoseismic investigations have previously investigated this segment, and the present study was conducted near its center, in an ∼180-km-long gap between existing studies. A paleoseismic trench revealed a sequence of eight sediment packages abutting a highly developed shear zone. Each of the packages consists of a fine-grained layer overlying a coarse-grained layer. Based on correlation between the age of the base of the coarse-grained layers and existing earthquake records, we infer that the coarse-grained layers were deposited in response to earthquakes because of increased erosion on an adjacent steep slope. The most recent event horizon may correlate to the historical 529 A.D. earthquake. Timing of six older earthquakes is constrained to (2s): 23 B.C.–103 A.D., 609–185 B.C., 971–814 B.C., 1227–968 B.C., 2050–1777 B.C., and 2556–2235 B.C., which correspond to a summed interevent time of 97–912 yr (2s). The earthquake record is relict because the local stream network was incised ca. 1000 A.D., isolating the trench site from its sediment source. A stream near the trench was subsequently offset by 23.5 ± 1.5 m, yielding a right-lateral slip rate of 21.4–25.6 mm/yr and suggesting that the 1943 rupture caused an uncharacteristically small offset. [less ▲]

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See detailRelief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure modifying drug trials
Pavelka, K.; Bruyère, Olivier ULg; Rovati, Lucio C et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 62-63

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See detailRelief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying drug trials
Pavelka, K.; Bruyère, Olivier ULg; Rovati, Lucio C et al

in Osteoarthritis and Cartilage (2003), 11(10), 730-737

Objective: To assess whether improvement in knee pain biased the determination of the structure-modifying effect reported for glucosamine sulfate in two recent 3-year, randomised, placebo-controlled ... [more ▼]

Objective: To assess whether improvement in knee pain biased the determination of the structure-modifying effect reported for glucosamine sulfate in two recent 3-year, randomised, placebo-controlled clinical trials, in which conventional standing antero-posterior full extension knee radiographs were used for the measurement of joint space narrowing, and in which pain relief might have improved knee full extension. Design: Patients completing the 3-year treatment course were selected based on a WOMAC pain decrease at least equal to the mean improvement in the glucosamine sulfate arms in either of the original studies, irrespective of treatment with glucosamine sulfate or placebo (drug responders or placebo responders). In a second approach, 3-year completers were selected if their baseline standing knee pain (item #5 of the WOMAC pain scale) was 'severe' or 'extreme' and improved by any degree at the end of the trials. In both cases, changes in minimum joint space width were compared between treatment groups. Results: Global knee pain was rnild-to-moderate in the two study populations and in all patient subsets identified. There were obviously more pain improvers in the glucosamine sulfate subsets (N=76 in the two studies combined) than in the placebo subsets (N=57), but WOMAC pain scores improved to the same extent, which was as large as over 50% relative to baseline. Nevertheless, the placebo subsets in both studies underwent an evident mean (SD) joint space narrowing, which in the pooled analysis of both studies was -0.22 (0.80) mm, and was not observed with glucosamine sulfate: +0.15 (0.60) mm (P=0.003 vs placebo). Similar results were found in the smaller subsets with greater than or equal to severe baseline standing knee pain that improved after 3 years, with a joint space narrowing nevertheless of -0.28 (0.76) mm with placebo (N=26), not observed with glucosamine sulfate: +0.21 (0.68) mm (N=31; P=0.014 vs placebo). Conclusions: Knee pain relief did not bias the report of a structure-modifying effect of glucosamine sulfate in two recent long-term trials using conventional standing antero-posterior radiographs, possibly due to the mild-to-moderate patient characteristics. (C) 2003 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailDe reliekenschat van de Benedictijnerabdij van Sint-Truiden
George, Philippe ULg

in Stof uit de kist. De middeleeuwse textielschat uit de abdij van Sint-Truiden (1991)

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See detailLe religieux et le politique en Afrique subsaharienne
Melice, Anne ULg

Scientific conference (2012, March)

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See detailLe religieux et le sacré vus à travers l’iconographie de l’olfaction
Dondero, Maria Giulia ULg

in Questions de Communication (2013), 23

This article explores the representation of olfactory sensoriality in modern religious painting as conveyed by the movement of clouds, and thus raises the question of the relationship between the ... [more ▼]

This article explores the representation of olfactory sensoriality in modern religious painting as conveyed by the movement of clouds, and thus raises the question of the relationship between the religious dimension of faith and the sacred contagion of transcendence. The representation of olfaction in pictorial iconography is compared with the disappearance of the holy bodies in contemporary artistic photography and perfume advertising. Interpretive propositions about the distinction of the religious and the sacred in relation to three corpuses are developed with a semiotic methodology. [less ▲]

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See detailReligion grecque
Pirenne-Delforge, Vinciane ULg

in Lehmann, Yves (Ed.) Religions de l’Antiquité (1999)

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See detailLes religions au Congo-Kinshasa
Melice, Anne ULg

Scientific conference (2010, March 23)

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See detailLe reliquaire du Trésor de la Cathédrale de Liège. Conservation, restauration et imagination
George, Philippe ULg

in Grammaccini, N.; Schurr, M. C. (Eds.) Kunst und Kulturtransfer zur Zeit Karls des Kühnen (2012)

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See detailUn reliquaire, "souvenir" du pèlerinage des Liégeois à Compostelle en 1056 ? provenant du trésor de Saint- Jacques à Liège
George, Philippe ULg

in Revue Belge d'Archéologie et d'Histoire de l'Art (1988), LVII

un objet arabe réutilisé au sein d'un trésor d'église et le premier pélerinage compostellien connu au nord des Alpes (1056)

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See detailReliquaires d'Herkenrode et de Robermont (Liège) et toile d'Englebert Fisen 1718
George, Philippe ULg

in Huy, 1990 : Filles de Cîteaux en Pays mosan, n° 75, 76, 136, n° 205 (1990)

Detailed reference viewed: 13 (2 ULg)