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See detailMyoferlin is a key regulator of EGFR activity in breast cancer.
Turtoi, Andrei ULg; Blomme, Arnaud ULg; Bellahcene, Akeila ULg et al

in Cancer Research (2013), 73

Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its ... [more ▼]

Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its expression in and contributions to cancer are not well established. In this study, we show that myoferlin is overexpressed in human breast cancers and that it is has a critical role in controlling degradation of the EGFR after its activation and internalization in breast cancer cells. Myoferlin depletion blocked EGF-induced cell migration and epithelial-to-mesenchymal transition. Both effects were induced as a result of impaired degradation of phosphorylated EGFR via dysfunctional plasma membrane caveolae and alteration of caveolin homooligomerization. In parallel, myoferlin depletion reduced tumor development in a chicken chorioallantoic membrane xenograft model of human breast cancer. Considering the therapeutic significance of EGFR targeting, our findings identify myoferlin as an novel candidate function to target for future drug development. [less ▲]

Detailed reference viewed: 97 (16 ULg)
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See detailMyoferlin is an essential component for VEGF-A production by pancreas cancer cells
Fahmy, Karim ULg

Scientific conference (2014, November 07)

Role of Myoferlon in Pancreas cancer cell growth and angiogenesis

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See detailMyoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer
Fahmy, Karim ULg; Gonzalez, Arnaud; Arafa, Mohammad et al

in International Journal of Cancer = Journal International du Cancer (2016), 138

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas ... [more ▼]

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis. However, the function of myoferlin in pancreas adenocarcinoma has not been reported. In other cell types, myoferlin is involved in several key plasma membrane processes such as fusion, repair, endocytosis and tyrosine kinase receptor activity. In this study, we showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. In addition to be smaller, the tumors formed by the myoferlin-silenced cells showed a marked absence of functional blood vessels. We further demonstrated that this effect was due, at least in part, to an inhibition of VEGFA secretion by BxPC-3 myoferlin-silenced cells. Using immunofluorescence and electron microscopy, we linked the decreased VEGFA secretion to an impairment of VEGFA exocytosis. The clinical relevance of our results was further strengthened by a significant correlation between myoferlin expression in a series of human pancreatic malignant lesions and their angiogenic status evaluated by the determination of the blood vessel density. [less ▲]

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See detailMyoferlin Regulates Endosomal Trafficking and Tunes Cancer Cell Metabolism
Blomme, Arnaud; Costanza, Brunella; Thiry, Marc ULg et al

Poster (2015, January 31)

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See detailMyoferlin regulates endosomal trafficking and tunes cancer cell metabolism
Blomme, Arnaud; Costanza, Brunella; Thiry, Marc ULg et al

Poster (2015, January 27)

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See detailMyoferlin: an indispensable component in VEGF-A secretion by pancreas cancer cells.
Fahmy, Karim ULg

Scientific conference (2015, May 13)

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See detailMyoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells
Fahmy, Karim ULg; Peulen, Olivier ULg; Castronovo, Vincenzo ULg et al

Poster (2015, January 31)

In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in ... [more ▼]

In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in pancreas cancer cells, BxPC-3, provoques a decrease in cell prolifération in vitro and a decrease in tumor volumes in animal model. Myoferlin silencing also provokes a decrease in VEGF-A secretion in the conditioned medium and that decrease was abserved in the animal model as a decrease in microvessels dencity. It appeared that this decrease in secretion is due to a a blockage in the exocytosis. Our data also showed a significate correlation between myoferlin expression and microvessels density in patients section. [less ▲]

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See detailMyoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells.
Fahmy, Karim ULg

Poster (2015, September 24)

In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in ... [more ▼]

In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in pancreas cancer cells, BxPC-3, provoques a decrease in cell prolifération in vitro and a decrease in tumor volumes in animal model. Myoferlin silencing also provokes a decrease in VEGF-A secretion in the conditioned medium and that decrease was abserved in the animal model as a decrease in microvessels dencity. It appeared that this decrease in secretion is due to a a blockage in the exocytosis. Our data also showed a significate correlation between myoferlin expression and microvessels density in patients section. [less ▲]

Detailed reference viewed: 34 (6 ULg)
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See detailMyoferlin: an indispensable component in VEGR-A secretion by pancreatic cancer cell
Fahmy, Karim; Gonzalez, Arnaud; Arafad, Mohamed et al

Poster (2015, January 27)

Detailed reference viewed: 20 (2 ULg)
Peer Reviewed
See detailMyofibrillar composition of some red- and white-blooded Antarctic teleosts
Feller, Georges ULg; Boinet, P.

in Molecular Physiology (1984), 5

Detailed reference viewed: 5 (0 ULg)
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See detailMyofibroblastic inflammatory urinary bladder tumors in dogs: report of 8 cases
Bohme, Béatrice; Ngendahayo, P.; Hamaide, Annick ULg et al

Poster (2008, July)

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See detailMyoglobine et infarctus du myocarde
Chapelle, Jean-Paul ULg

Conference (1990, June 27)

Detailed reference viewed: 3 (0 ULg)
See detailMyoglobine: méthodes analytiques et interprétation clinique
Chapelle, Jean-Paul ULg

Conference (1991, March 25)

Detailed reference viewed: 26 (0 ULg)
See detailMyoglobinurie atypique chez les chevaux au pré
Delguste, Catherine ULg

Conference (2002, November 30)

Detailed reference viewed: 17 (2 ULg)
See detailMyoglobinurie atypique chez les chevaux au pré: une série de cas en Belgique
Delguste, Catherine ULg

Master of advanced studies dissertation (2002)

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liège between November 2000 and April 2001 ... [more ▼]

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liège between November 2000 and April 2001, with a clinical history suggesting atypical myoglobinuria. Lesions were similar to those previously described. All horses were at rest and grazing when they developed clinical signs. Three times, the syndrome killed several horses grazing together. Horses were generally found recumbent, nearly or totally unable to stand up. They were presenting tachycardia, polypnoea and myoglobinuria, and died rapidly. When performed, blood analysis revealed severe muscular enzymatic activity rises. Histopathology revealed pulmonary congestion and oedema, and squeletal muscular fibers degeneration, mostly in respiratory and postural muscles. These observations are in accordance with cases of atypical myoglobinuria previously described in UK and Germany. The aetiology of this pathology is still unknown, despite of research attempts. An epidemiological inquiry protocol was developed in order to investigate upcoming cases within the scope of aetiologic research. Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liège between November 2000 and April 2001, with a clinical history suggesting atypical myoglobinuria. Lesions were similar to those previously described. All horses were at rest and grazing when they developed clinical signs. Three times, the syndrome killed several horses grazing together. Horses were generally found recumbent, nearly or totally unable to stand up. They were presenting tachycardia, polypnoea and myoglobinuria, and died rapidly. When performed, blood analysis revealed severe muscular enzymatic activity rises. Histopathology revealed pulmonary congestion and oedema, and squeletal muscular fibers degeneration, mostly in respiratory and postural muscles. These observations are in accordance with cases of atypical myoglobinuria previously described in UK and Germany. The aetiology of this pathology is still unknown, despite of research attempts. An epidemiological inquiry protocol was developed in order to investigate upcoming cases within the scope of aetiologic research. [less ▲]

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See detailMyoglobinurie atypique: nouveaux cas en Belgique et en France
Delguste, Catherine ULg; Amory, Hélène ULg

in Proceedings of the 19th annual meeting of the Belgian Equine Practitioners Society (BEPS) (2002)

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See detailMyoglobinurie atypique: nouveaux cas en Belgique et en France
Delguste, Catherine ULg; Amory, Hélène ULg

Conference (2002, November 09)

Detailed reference viewed: 8 (0 ULg)
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See detailMyoglobinurie atypique: une série de cas en Belgique
Delguste, Catherine ULg; Cassart, Dominique ULg

Conference (2001, November 10)

Detailed reference viewed: 22 (5 ULg)
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See detailMyographe pour l’étude de la période latente
Fredericq, Léon ULg

in Archives de Biologie (1882), III

Detailed reference viewed: 16 (0 ULg)