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Peer Reviewed
See detailMethylglyoxal-induced carbonyl stress: perspectives of a new anti-GBM therapy
Nokin, Marie-Julie ULg

Conference (2017, February 24)

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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailMethylmercury and selenium in vitro effects on harbor seal (Phoca vitulina) lymphocytes : a multidisciplinary approach
Dupont, Aurélie ULg; Bouquegneau, Jean-Marie ULg; Das, Krishna ULg et al

Poster (2010, May 26)

Methylmercury (MeHg) bioaccumulates along the food web, leading to the highest levels in tissues of predatory species. It constitutes the predominant form present in the blood of marine mammals. The blood ... [more ▼]

Methylmercury (MeHg) bioaccumulates along the food web, leading to the highest levels in tissues of predatory species. It constitutes the predominant form present in the blood of marine mammals. The blood cells, including the immune cells, are therefore exposed to the toxic properties of that chemical. Nevertheless, selenium (Se) is an essential element absorbed concomitantly to MeHg which seems to modulate this toxicity. The goal of this study is to evaluate the immunotoxicity of MeHg on the harbor seal (Phoca vitulina) T lymphocytes, highly important in the adaptive immune response, and to investigate the modulating effect of Se on that toxicity. In parallel, the concentrations of MeHg, total mercury (T-Hg) and Se are determined in free-ranging harbour seal blood in order to follow their contamination levels. The T lymphocytes were isolated from the whole blood, exposed to various MeHg and Se concentrations and the exposure effects were estimated by functional tests including the evaluation of viability, proliferation, metabolic activity, DNA and protein synthesis, and by morphological analysis by transmission electron microscopy. The mean T-Hg concentration was 172 ± 143 µg/l of whole blood. The T lymphocytes cultures in vitro displayed a decreasing number of viable cells with increasing concentrations of MeHg, and numerous ultrastructural defects. The cells exposed to MeHg notably displayed distortion of the plasmic membrane, nucleus fragmentations, chromatin compaction, swelling mitochondrias and cytoplasmic vacuolisations. Those results highlighted various immunotoxic effects of MeHg, both at the functional and ultrastructural levels. The antagonistic role of Se on MeHg immunotoxicity is discussed. [less ▲]

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See detailMethylmercury in vitro exposure of harbor seal (Phoca vitulina) lymphocytes: a multidisciplinary approach
Dupont, Aurélie ULg; Siebert, Ursula; Rosenberger, Tanja et al

Poster (2009, June 08)

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See detailUn métier à tisser thérapeutique
Triffaux, Jean-Marc ULg; Gayetot, Delphine ULg; Izzi, Isabelle

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2008), 10

Detailed reference viewed: 47 (2 ULg)
See detailLe métier d'ingénieur du son selon Jean-Pierre Duret et Benoit De Clerck
Tomasovic, Dick ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 99 (6 ULg)
See detailLe métier de chercheur : Des parcours singuliers à la carrière traditionnelle profilée
Remy, Céline ULg; Balon, Floriane

Conference (2015, March 11)

Detailed reference viewed: 26 (1 ULg)
See detailLe métier de chercheur – la problématique des archives militaires
Bechet, Christophe ULg

Scientific conference (2014, November 19)

Detailed reference viewed: 21 (1 ULg)
See detailLe métier de gestionnaire de recherche
Jeandrain, Denys ULg

Conference (2012, September 25)

Detailed reference viewed: 30 (10 ULg)
Peer Reviewed
See detaille métier de journaliste à l’heure des réseaux sociaux-. Entretien avec François Colmant
Charlotte Collot; Colmant, François ULg

Article for general public (2012)

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See detailLe métier de médiateur scolaire en Communauté française de Belgique
Dethier, Baptiste ULg

Scientific conference (2011, November 04)

Dans le contexte d’un pluralisme normatif croissant et d’une école qui subit d’importantes mutations à travers une crise de l’autorité et de la légitimité, la médiation scolaire est apparue comme une ... [more ▼]

Dans le contexte d’un pluralisme normatif croissant et d’une école qui subit d’importantes mutations à travers une crise de l’autorité et de la légitimité, la médiation scolaire est apparue comme une réponse à la difficulté d’adéquation entre la société et le milieu scolaire. L’étude que nous avons réalisée sur les dispositifs et les acteurs de la médiation scolaire en Belgique francophone permet de mieux saisir les caractéristiques et surtout l’hétérogénéité du travail de ces nouveaux acteurs. Issus de réponses politiques ou d’initiatives locales, ils se réapproprient de multiples façons le concept de médiation et les directives imprécises qui leur sont données. À ce titre, les apports récents de la sociologie des professions nous aideront dans l’analyse de leur « situation professionnelle ». [less ▲]

Detailed reference viewed: 119 (27 ULg)
See detailLe métier de parents : Evolution des ouvrages d'éducation
Mougenot, Catherine ULg; Mormont, Marc ULg

Book published by Institut des Sciences Politiques et Sociales (1974)

La diffusion du savoir éducatif. De l'éducation traditionnelle aux conditions sociales d'apparition et de diffusion d'une éducation moderne.

Detailed reference viewed: 19 (4 ULg)
See detailLe métier de script, la mémoire et la cohérence du film. Rencontre avec Marie-Florence Roncayolo et Marika Piedboeuf.
Tomasovic, Dick ULg

Conference given outside the academic context (2016)

Evocation du métier et du regard du scripte en compagnie de Marie-Florence Roncayolo et Marika Piedboeuf.

Detailed reference viewed: 11 (1 ULg)
See detailLe métier de scripte, d’une génération à l’autre
Jousten, Lison ULg

Article for general public (2013)

Le 8 février 2013, dans le cadre des Conférences du Conservatoire des Techniques, s’est tenue à la Cinémathèque française une rencontre destinée à lever le voile sur le métier de scripte, une fonction du ... [more ▼]

Le 8 février 2013, dans le cadre des Conférences du Conservatoire des Techniques, s’est tenue à la Cinémathèque française une rencontre destinée à lever le voile sur le métier de scripte, une fonction du cinéma souvent méconnue. La structure polyphonique de cette conférence, assumée par trois générations de scriptes, a notamment permis de retracer l’évolution de la profession dans ses grandes lignes ainsi que dans quelques-unes de ses transformations. [less ▲]

Detailed reference viewed: 35 (5 ULg)