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See detailMultiple pulmonary arteriovenous malformations.
Quaden, C.; Ghaye, Benoit ULg; Dondelinger, Robert ULg et al

in Lancet (2002), 359(9322),

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See detailMultiple Realities of Virtual Architecture, Opening Session of Virtual Techniques for Architecture
Leclercq, Pierre ULg; Martin, G.

in Fisher, X.; Coutellier, D. (Eds.) Proceedings of Virtual Concept Conference '05 - Research in Interactive Design (2005)

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See detailMultiple Redox Regulation in Nf-Kappab Transcription Factor Activation
Piette, Jacques ULg; Piret, Bernard; Bonizzi, Giuseppina et al

in Biological Chemistry (1997), 378(11), 1237-45

The well-known Rel/NF-kappaB family of vertebrate transcription factors comprises a number of structurally related, interacting proteins that bind DNA as dimers and whose activity is regulated by ... [more ▼]

The well-known Rel/NF-kappaB family of vertebrate transcription factors comprises a number of structurally related, interacting proteins that bind DNA as dimers and whose activity is regulated by subcellular location. This family includes many members (p50, p52, RelA, RelB, c-Rel, ...), most of which can form DNA-binding homo- or hetero-dimers. All Rel proteins contain a highly conserved domain of approximately 300 amino-acids, called the Rel homology domain (RH), which contains sequences necessary for the formation of dimers, nuclear localization, DNA binding and IkappaB binding. Nuclear expression and consequent biological action of the eukaryotic NF-kappaB transcription factor complex are tightly regulated through its cytoplasmic retention by ankyrin-rich inhibitory proteins known as IkappaB. The IkappaB proteins include a group of related proteins that interact with Rel dimers and regulate their activities. The interaction of a given IkappaB protein with a Rel complex can affect the Rel complex in distinct ways. In the best characterized example, IkappaB-alpha interacts with a p50/RelA (NF-kappaB) heterodimer to retain the complex in the cytoplasm and inhibit its DNA-binding activity. The NF-kappaB/IkappaB-alpha complex is located in the cytoplasm of most resting cells, but can be rapidly induced to enter the cell nucleus. Upon receiving a variety of signals, many of which are probably mediated by the generation of reactive oxygen species (ROS), IkappaB-alpha undergoes phosphorylation at serine residues by a ubiquitin-dependent protein kinase, is then ubiquitinated at nearby lysine residues and finally degraded by the proteasome, probably while still complexed with NF-kappaB. Removal of IkappaB-alpha uncovers the nuclear localization signals on subunits of NF-kappaB, allowing the complex to enter the nucleus, bind to DNA and affect gene expression. Like proinflammatory cytokines (e.g. IL-1, TNF), various ROS (peroxides, singlet oxygen, ...) as well as UV (C to A) light are capable of mediating NF-kappaB nuclear translocation, while the sensor molecules which are sensitive to these agents and trigger IkappaB-alpha proteolysis are still unidentified. We also show that a ROS-independent mechanism is activated by IL-1beta in epithelial cells and seems to involve the acidic sphingomyelinase/ceramide transduction pathway. [less ▲]

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See detailMultiple regression and crops yields prediction on basis of meteorological data
Dagnelie, P.; Palm, Rodolphe ULg

in XVIth International Biometric Conference Proceedings, Hamilton, New Zealand, 7-11 December 1992 : Proceedings of contributed papers (1992, December)

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See detailMultiple roles for plasminogen activator system in nervous system development
Leprince, Pierre ULg; Rogister, Bernard ULg; Delrée, Paul et al

in Serine proteases and their serpin inhibitors in the Nervous System (1990)

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See detailMultiple roles of Hoxc8 in skeletal development
Juan, A. H.; Lei, H. Y.; Bhargava, P. et al

in Annals of the New York Academy of Sciences (2006), 1068

We are interested in investigating the function of Hoxc8 in skeletogenesis during mouse development. Previous studies have shown that deregulation of Hoxc8 expression in the mouse leads to several ... [more ▼]

We are interested in investigating the function of Hoxc8 in skeletogenesis during mouse development. Previous studies have shown that deregulation of Hoxc8 expression in the mouse leads to several skeletal defects, such as homeotic transformation in the thoracic vertebrae, abnormal development of the rib cage, and overproliferation of chondrocytes in the hypertrophic area. By deleting a crucial enhancer of Hoxc8 in vivo, we found that precise temporal expression of Hoxc8 is important for determining the correct identity of the vertebral column in early embryos. We also identified downstream targets of Hoxc8 relevant to osteoblast differentiation at later developmental stages. [less ▲]

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See detailMultiple rotations of a drop rolling inside a horizontal circular hydraulic jump
Duchesne, Alexis ULg; Savaro, Clément; Lebon, Luc et al

in Europhysics Letters [=EPL] (2013), 102

We explore the complex dynamics of a non-coalescing drop of moderate size inside a circular hydraulic jump of the same liquid formed on a horizontal disk. In this situation the drop is moving along the ... [more ▼]

We explore the complex dynamics of a non-coalescing drop of moderate size inside a circular hydraulic jump of the same liquid formed on a horizontal disk. In this situation the drop is moving along the jump and one observes two different motions: a periodic one (it orbits at constant speed) and an irregular one involving reversals of the orbital motion. Modeling the drop as a rigid sphere exchanging friction with liquid across a thin film of air, we rationalize both the orbital motion and the internal rotation of the drop. This internal rotation is evidenced by tracer visualization and exhibits an unexpected dependence upon drop size. [less ▲]

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See detailMultiple scales solution for a beam with a small bending stiffness
Denoël, Vincent ULg; Detournay, Emmanuel

in Journal of Engineering Mechanics (2010), 136(1), 69-77

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See detailThe multiple SEA method: a method to synthesize Pt/carbon xerogel catalysts for Proton Exchange Membrane Fuel Cells (PEMFC)
Zubiaur, Anthony ULg; Chatenet, Marian; Maillard, Frédéric et al

Poster (2013, April)

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See detailMultiple seawater-derived geochemical signatures in Indian oceanic pelagic clays
Fagel, Nathalie ULg; André, Luc; Debrabant, Pierre

in Geochimica et Cosmochimica Acta (1997), 61(5), 989-1008

This paper reports a geochemical study of oceanic clays. Major and trace elements were analyzed on smectite-rich, clay size (<2 mu m) samples, bulk sediments, and leachate residues from the Central Indian ... [more ▼]

This paper reports a geochemical study of oceanic clays. Major and trace elements were analyzed on smectite-rich, clay size (<2 mu m) samples, bulk sediments, and leachate residues from the Central Indian Basin. Sr-Nd isotopes were also studied to investigate their geochemical evolution during transport in the water column, sedimentation, and diagenesis. The region is of special interest because the sedimentation records the interaction between the detrital supply from the Bengal Fan in the north and the biosiliceous input associated with the equatorial divergence in the south. The clay size fractions display extremely variable trace element contents, e.g., [Ba] = 100-5000 ppm, [Sr] = 20-200 ppm, Ce/Ce* = 0.9-3.3, [Nd] = 10-50 ppm. Although in the argillaceous samples, clay size fractions have a similar trace element imprint to the bulk sediment, some major fractionations occur in the biosiliceous samples between the clay and the bulk sediment, especially for Sr and rare earth elements (REE). Three major components may account for the variable geochemical signatures of these pelagic clays. The first component (component A), already identified by Fagel et al. (1994), is characterized by a homogeneous geochemical signature (La-N/Yb-N = 1.03-1.05; Th/Ta = 12.8-21.1; Ba/Th similar to 28) and a nonradiogenic Nd isotopic composition (Nd-143/Nd-144 similar to 0.511880): it traces a detrital Himalayan-derived origin. The two other components display a seawater-derived isotopic composition with global Sr (Sr-87/Sr-86 similar to 0.709060) and regional Indian Ocean Nd(Nd-143/Nd-144 similar to 0.512200) signatures. Both components are enriched in Sr and Ba (Sr similar to 150 ppm, Ba/Th similar to 500), and they are either enriched in light rare earth elements (LREE, e.g., Nd similar to 50 ppm) in the argillaceous sediments (component B) or LREE-depleted (Nd < 20 ppm) in the biosiliceous sediments (component C). The frequent occurrence of micrometric (<5 mu m) Sr-REE-Th enriched barite grains showing three major habits (rhombic, rounded, dendritic) suggests that these biologically-derived mineral phases had a major role in the genesis of components B and C. A strong clay-barite equilibration is deduced from the Post Archean Australian Shales PAAS-like REE patterns of these barites and the Ba enrichment of the clays. We suggest that it results from two successive mechanisms of exchange. First, at the top of the oxygen minimum zone, the microbial-induced decay of organic matter is proposed to trigger a series of trace element transfers between the various particulate-forming components (clays, barites, and decaying organic coatings). This is proposed as the origin of the clay component B: the barite-derived components (Ba, Sr) and the organic-derived positive Ce anomaly are imported to the clay particles while the PAAS signature of the clays is retained by the remaining barite crystals. Second, after settling, the barites are believed to partly dissolve and recrystallize, especially in the anoxic part of the sedimentary column. This diagenetic barite dissolution is proposed as the origin of the clay component C. Copyright (C) 1997 Elsevier Science Ltd. [less ▲]

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See detailMultiple sources in the copularization of become
Petré, Peter ULg

Conference (2010, September 04)

Multiple sources in the copularization of become This paper shows how general productivity (see Barðdal 2009: 38) of the copular function of the verb become abruptly followed when a pre-copular stage had ... [more ▼]

Multiple sources in the copularization of become This paper shows how general productivity (see Barðdal 2009: 38) of the copular function of the verb become abruptly followed when a pre-copular stage had reached a threshold value about 1150, prior to which become only occurred with a spatial sense ‘arrive’, and with extensions of this sense. It is argued that this abrupt switch to general productivity rather than a gradual increase in productivity results from the fact that copular become is not the end result of a single diachronic lineage of constructions (i.e. a simple grammaticalization process, see Croft 2000: 32-37), but instead resulted from an interaction between lineages, as well as external influence, and from the coming together of all factors involved in the twelfth century. First, certain constructions in which become occurred gradually changed and interacted with each other. In a first stage, two constructions developed (through metaphor) out of become ‘arrive’. These are the constructions in (1), with a human subject and become meaning ‘attain’, and in (2), with an inanimate subject, a dative experiencer and become meaning ‘come upon’. (1) Heo becom to soþum wisdome. ‘She attained to true wisdom.’ (2) Seo þearlwisnis þæs heardan lifes him becwom. ‘The austerity of life came upon him.’ In a second stage a two-participant resultative construction, as in (3), developed as a syntactic blend of (1) and (2) (cf. De Smet 2009: 1747), which provided a formal template for a one-participant prepositional copular construction as in (4). (3) Andetnysse him becumeð to hæle ‘Confession results (for him) in salvation’ (4) Þii fader bi-com to one childe ‘Your father turned into a child.’ Another, unrelated construction provided a formal template for the adjectival copular construction. This is the depictive construction given in (5), in which an adjective serves as a secondary predicate, but become does not have a linking function (is not a copula). (5) He gesund becom to Æðelingege. ‘He arrived (and was) safe at Æðelinge.’ Second, the already existing copula weorðan ‘become’ (see Petré & Cuyckens 2009) provided a template of general productivity upon which the resultative construction could graft once it had become semantically sufficiently similar to a copular construction, and, once the copular stage was reached, the depictive construction also started to serve as a formal input for this analogical process, with as a result adjectival and nominal copular constructions. Finally, Old French probably also contributed (though only as a strengthening factor) to the success of copular become in precisely the twelfth century. From a balanced explanation taking into account all of these factors it is concluded that the sudden emergence of copular becuman is not as catastrophic as it at first seemed. References Barðdal, Jóhanna. 2009. Productivity: Evidence from case and argument structure in Icelandic (Constructional Approaches to Language 8). Amsterdam: John Benjamins. Croft, William. 2000. Explaining language change: an evolutionary approach. London: Longman. De Smet, Hendrik. 2009. Analysing reanalysis. Lingua 119: 1728-1755. Petré, Peter & Hubert Cuyckens. 2009. Constructional change in Old and Middle English Copular Constructions and its impact on the lexicon. Folia Lingistuica Historia 30: 311-365. [less ▲]

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See detailMultiple sparse priors for the M/EEG inverse problem.
Friston, Karl; Harrison, Lee; Daunizeau, Jean et al

in NeuroImage (2008), 39(3), 1104-20

This paper describes an application of hierarchical or empirical Bayes to the distributed source reconstruction problem in electro- and magnetoencephalography (EEG and MEG). The key contribution is the ... [more ▼]

This paper describes an application of hierarchical or empirical Bayes to the distributed source reconstruction problem in electro- and magnetoencephalography (EEG and MEG). The key contribution is the automatic selection of multiple cortical sources with compact spatial support that are specified in terms of empirical priors. This obviates the need to use priors with a specific form (e.g., smoothness or minimum norm) or with spatial structure (e.g., priors based on depth constraints or functional magnetic resonance imaging results). Furthermore, the inversion scheme allows for a sparse solution for distributed sources, of the sort enforced by equivalent current dipole (ECD) models. This means the approach automatically selects either a sparse or a distributed model, depending on the data. The scheme is compared with conventional applications of Bayesian solutions to quantify the improvement in performance. [less ▲]

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See detailMultiple spectroscopic study of in vitro photodynamic therapy induced by PPME
Guelluy, Pierre-Henri ULg; Quoilin, Caroline; Grammenos, Angeliki ULg et al

Conference (2010, June 01)

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See detailThe multiple spots of the Ganymede auroral footprint
Bonfond, Bertrand ULg; Hess, Sébastien; Bagenal, Fran et al

in Geophysical Research Letters (2013), 40

The interaction between the moons and the magnetosphere of giant planets sometimes gives rise to auroral signatures in the planetary ionosphere, called the satellite footprints. So far, footprints have ... [more ▼]

The interaction between the moons and the magnetosphere of giant planets sometimes gives rise to auroral signatures in the planetary ionosphere, called the satellite footprints. So far, footprints have been detected for Io, Europa, Ganymede, and Enceladus. These footprints are usually seen as single spots. However, the Io footprint, the brightest one, displays a much more complex morphology made of at least three different spots and an extended tail. Here we present Hubble Space Telescope FUV images showing evidence for a second spot in the Ganymede footprint. The spots separation distance changes as Ganymede moves latitudinally in the plasma sheet, as is seen for the Io footprint. This indicates that the processes identified at Io are universal. Moreover, for similar Ganymede System III longitudes, the distance may also vary significantly with time, indicating changes in the plasma sheet density. We identified a rapid evolution of this distance 8 days after the detection of a volcanic outburst at Io, suggesting that such auroral observations could be used to estimate the plasma density variations at Ganymede. [less ▲]

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See detailThe multiple spots of the Ganymede footprint
Bonfond, Bertrand ULg; Hess, S.; Grodent, Denis ULg et al

Poster (2011, July 11)

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See detailMultiple System Organ Failure after open-heart surgery in infants and children
Seghaye, Marie-Christine ULg; Engelhardt, W.; Grabitz, R. G. et al

in Thoracic and Cardiovascular Surgeon (1993), 41(1), 49-53

Between January 1985 and March 1989 we retrospectively observed Multiple System Organ Failure (MSOF) in 16 of 460 children (3.5%) who underwent cardiac surgery with cardiopulmonary bypass for congenital ... [more ▼]

Between January 1985 and March 1989 we retrospectively observed Multiple System Organ Failure (MSOF) in 16 of 460 children (3.5%) who underwent cardiac surgery with cardiopulmonary bypass for congenital heart disease. MSOF was arbitrarily defined as a clinical entity with failure of two or more vital organ systems associated with high fever, thrombocytopenia, and cardiocirculatory insufficiency and occurring within the first postoperative week. In 13 children the first clinical manifestations of MSOF were evident on the first postoperative day and in the other 3 on the second or third postoperative day. All children showed acute renal failure, acute hepatic failure, high fever, and thrombocytopenia. Most of them showed respiratory insufficiency and neurological involvement. Seven of the 16 children died. Four of the 9 surviving patients had neurological sequelae still present 6 months after the operation, and the others recovered completely. [less ▲]

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See detailMultiple timescale spectral analysis
Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2015), 39(0), 69--86

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the ... [more ▼]

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the steady-state second order cumulant of a linear oscillator, under the action of a stationary loading prescribed by means of its power spectral density. There exists however a broad variety of such similar problems, extending the concept to multi degree-of-freedom systems, non Gaussian excitation, slightly nonlinear oscillators or even transient excitations. In this wide class of problems, the cumulants of the response are obtained as the result of the integral of corresponding spectra over the frequency space, which is possibly multidimensional. Application of standard numerical integration techniques may be prohibitive, a reason why the spectral approach is often left aside. Besides, many engineering problems involve a clear timescale separation, usually of those pertaining to the loading and to the mechanical behavior of the system. In these problems, a proper consideration of the timescale separation results in dropping the order of integration by one, at least. This offers the possibility to derive analytical solutions, whenever the order of integration drops to zero, or to make numerical integration competitive. The paper presents this general method, together with some applications in wind and marine engineering. [less ▲]

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See detailMultiple types of cardiac arrhythmias in a child with head injury and raised intracranial pressure.
Grosse-Wortmann, L.; Bindl, L.; SEGHAYE, Marie-Christine ULg

in Pediatric Cardiology (2006), 27(2), 286-8

Arrhythmias occur as a life-threatening complication in adults with severe head injuries. A wide spectrum of brady- and tachyarrhythmias and different pathogenetic mechanisms have been described. We ... [more ▼]

Arrhythmias occur as a life-threatening complication in adults with severe head injuries. A wide spectrum of brady- and tachyarrhythmias and different pathogenetic mechanisms have been described. We report an 8-year-old boy with traumatic brain injury who developed a variety of independent types of arrhythmias during the course of his illness, including supraventricular and ventricular extrasystoles, prolonged QT duration and ventricular fibrillation, accelerated junctional rhythm, and reentry tachycardia. Each arrhythmia may have had a distinct pathogenic pathway, and not all were associated with raised intracranial pressure. [less ▲]

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