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See detailMultidrug resistance gene-1 polymorphisms and resistance to cyclosporine a in patients with steroid resistant ulcerative colitis
Daniel, F.; Loriot, M. A.; Seksik, P. et al

in Inflammatory Bowel Diseases (2007), 13(1), 19-23

Background: Cyclosporine A (CsA) is inconstantly effective in inducing remission in acute attacks of ulcerative colitis (UC) not responding to steroids. This study aimed to establish whether multidrug ... [more ▼]

Background: Cyclosporine A (CsA) is inconstantly effective in inducing remission in acute attacks of ulcerative colitis (UC) not responding to steroids. This study aimed to establish whether multidrug resistance gene (MDR)1 polymorphisms would be associated with CsA failure. Patients and Methods: The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium. Patients were classified as CsA failure (n = 50) when they needed colectomy within 30 days after CsA initiation. The SNPs were detected by use of a 5' nuclease allelic discrimination assay. Results: There was a significant association between the G2677T/A polymorphism distribution (exon 21) and the risk for CsA failure (P = 0.0001). The TT genotype of exon 21 was significantly associated with the risk compared with the two other genotypes (odds ratio, 3.77; 95% confidence interval, 1.42-9.97, P = 0.007). There was no significant association between the genotype C3435T distribution (exon 26) and the risk of CsA failure (P = 0.23). Conclusion: The TT genotype of exon 21 MDR1 polymorphisms is associated with a higher risk of CsA failure in patients with steroid resistant UC. Further studies should be performed to establish whether other treatments could be more efficient to avoid surgery in this subset of patients. [less ▲]

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See detailMultidsiciplinary Management of Migraine: Pharmacological, Manual And Other Therapies.
Fernández-de-las-Peñas, C; Chaitow, L; Schoenen, Jean ULg

Book published by Jones & Bartlett Learning (2012)

Detailed reference viewed: 134 (2 ULg)
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See detailMultifacedted phenotype of a modified overproducing Bacillus subtilis strain
Leclere, V.; Bechet, M.; Adam, A. et al

Poster (2005)

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See detailMultifaceted dermal ultrastructural clues for Ehlers-Danlos syndrome with arterial rupture and type I collagen R-to-C substitution.
Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg

in American Journal of Dermatopathology (2007), 29(5), 449-51

Type I collagen arginine-to-cysteine (R-to-C) substitutions were found in three middle-aged adults suffering from spontaneous dissection of medium-size arteries. This disorder enters the heterogeneous ... [more ▼]

Type I collagen arginine-to-cysteine (R-to-C) substitutions were found in three middle-aged adults suffering from spontaneous dissection of medium-size arteries. This disorder enters the heterogeneous spectrum of the Ehlers-Danlos syndrome (EDS). Despite similar genetic mutation and arterial alterations, two distinct clinical presentations were identified showing signs of either the EDS classic type or premature osteopenia alone. Ultrastructural changes were found in the dermal collagen fibrils, elastic fibers, and proteoglycan components. The cross-section of most collagen fibrils was rounded, but with diverse diameters. Flower-like outlines of collagen fibrils were rarely disclosed. Large hyaluronic acid globules pushed apart the collagen bundles in the case with EDS classic-type presentation. Elastic fibers contained unusual annular microcalcifications. In conclusion, ultrastructural changes were found in diverse connective-tissue components despite the fact that the mutations were found to be specific for the collagen molecules. In addition, two distinct clinical presentations were found and were correlated with peculiar ultrastructural alterations. [less ▲]

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See detailThe multifaceted struggle for power in the bioeconomy
Delvenne, Pierre ULg; Hendrickx, Kim ULg

in Technology in Society (2013), 35(2),

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See detailMultifactorial Optimization of Contrast-Enhanced Nanofocus Computed Tomography for Quantitative Analysis of Neo-Tissue Formation in Tissue Engineering Constructs.
Sonnaert, Maarten; Kerckhofs, Greet; Papantoniou, Ioannis et al

in PloS one (2015), 10(6), 0130227

To progress the fields of tissue engineering (TE) and regenerative medicine, development of quantitative methods for non-invasive three dimensional characterization of engineered constructs (i.e. cells ... [more ▼]

To progress the fields of tissue engineering (TE) and regenerative medicine, development of quantitative methods for non-invasive three dimensional characterization of engineered constructs (i.e. cells/tissue combined with scaffolds) becomes essential. In this study, we have defined the most optimal staining conditions for contrast-enhanced nanofocus computed tomography for three dimensional visualization and quantitative analysis of in vitro engineered neo-tissue (i.e. extracellular matrix containing cells) in perfusion bioreactor-developed Ti6Al4V constructs. A fractional factorial 'design of experiments' approach was used to elucidate the influence of the staining time and concentration of two contrast agents (Hexabrix and phosphotungstic acid) and the neo-tissue volume on the image contrast and dataset quality. Additionally, the neo-tissue shrinkage that was induced by phosphotungstic acid staining was quantified to determine the operating window within which this contrast agent can be accurately applied. For Hexabrix the staining concentration was the main parameter influencing image contrast and dataset quality. Using phosphotungstic acid the staining concentration had a significant influence on the image contrast while both staining concentration and neo-tissue volume had an influence on the dataset quality. The use of high concentrations of phosphotungstic acid did however introduce significant shrinkage of the neo-tissue indicating that, despite sub-optimal image contrast, low concentrations of this staining agent should be used to enable quantitative analysis. To conclude, design of experiments allowed us to define the most optimal staining conditions for contrast-enhanced nanofocus computed tomography to be used as a routine screening tool of neo-tissue formation in Ti6Al4V constructs, transforming it into a robust three dimensional quality control methodology. [less ▲]

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See detailMultifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms
NCHIMI LONGANG, Alain ULg; CHERAMY-BIEN, Jean-Paul ULg; Gasser, T. Christian et al

in Circulation. Cardiovascular imaging (2014), 7

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG ... [more ▼]

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET). METHODS AND RESULTS: -The study included 53 patients (45 males) with aortic aneurysms, 47 infrarenal (AAA) and 6 thoracic (TAA), who had at least one 18F-FDG PET/computed tomography. Over a 30-month period, more clinical events occurred in patients with increased 18F-FDG uptake on their last examination than in those without (5/18 (28%) vs. 2/35 (6%); P=0.03). Wall stress and stress/strength index computed by FES and 18F-FDG uptake were evaluating a total of 68 examinations. 25 (38%) examinations demonstrated at least one aneurysm wall area of increased 18F-FDG uptake. The mean number of these areas per examination was 1.6 (18/11) in TAAs vs. 0.25 (14/57) in AAAs, while the mean number of increased uptake areas co-localizing with highest wall stress and stress/strength index areas was 0.55 (6/11) and 0.02 (1/57), respectively. Quantitatively, 18F-FDG PET uptake correlated positively with both wall stress and stress/strength index (P<0.05). 18F-FDG uptake was particularly high in subjects with personal history of angina pectoris and familial aneurysm. CONCLUSIONS: -Increased 18F-FDG PET uptake in aortic aneurysms is strongly related to aneurysm location, wall stress as derived by FES and patient's risk factors such as acquired and inherited susceptibilities. [less ▲]

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See detailMultifocal choroid plexus papilloma: a case report.
Scholsem, Martin; Scholtes, Félix ULg; Robe, Pierre ULg et al

in Clinical neuropathology (2012), 31(6), 430-4

BACKGROUND: Multiple choroid plexus papillomas (CPPs) are rare. Usually, they correspond to villous hypertrophy or metastasis occurring during cerebrospinal dissemination. Multiple CPPs have rarely been ... [more ▼]

BACKGROUND: Multiple choroid plexus papillomas (CPPs) are rare. Usually, they correspond to villous hypertrophy or metastasis occurring during cerebrospinal dissemination. Multiple CPPs have rarely been reported as synchronous tumors. CASE REPORT: Three synchronous CPPs were resected in a 59-year-old female 6 years after their first imaging description. Pathology showed mucus-producing CPP in all 3, 1 of the 3 presenting some signs of atypia. No p53 or hSNF5/INI1 mutation, or signs of polyoma viruses infection were found. CONCLUSION: Although no clear cause for the multifocality was found, the simultaneous presence of the three tumors and their benign histology suggest that they were synchronous and not metastatic. The issue of differentiating synchronous CPPs from metastatic CPP is discussed. [less ▲]

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See detailMultifocal motor and sensory neuropathy following whiplash injury
DIVE, Dominique ULg; NOEZ, Stéphanie ULg; ISERENTANT, Cynthia ULg et al

in Journal of Neurology (2001)

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See detailMultifocal serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma
Quatresooz, Pascale ULg; Honore, Pierre ULg; Vivario, M. et al

in Annales de Pathologie (2002), 22(4), 317-320

Pancreatic cysts are common, but cystic tumors are uncommon. We report a rare case of serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma which supports a common etiopathogeny of ... [more ▼]

Pancreatic cysts are common, but cystic tumors are uncommon. We report a rare case of serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma which supports a common etiopathogeny of these tumors. We discuss the differential diagnosis with mucinous cystadenoma which is potentially malignant and recall the microscopic and radiologic features. [less ▲]

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See detailA multifractal analysis of air temperature signals based on the wavelet leaders method
Deliège, Adrien ULg; Nicolay, Samuel ULg

Conference (2014, August 20)

We present the wavelet leaders method (introduced by S. Jaffard) as a tool to study the Hölder regularity of signals, which is closely related to some functional spaces. We use the associated multifractal ... [more ▼]

We present the wavelet leaders method (introduced by S. Jaffard) as a tool to study the Hölder regularity of signals, which is closely related to some functional spaces. We use the associated multifractal formalism to show that surface air temperature signals are monofractal, i.e. these are regularly irregular. Then we use this result to establish a climate classification of weather stations in Europe which matches the Köppen-Geiger climate classification. This result could give rise to new criteria to determine the effectiveness of current climatic models. [less ▲]

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See detailMultifractal analysis of air temperature signals using the wavelet leaders method
Deliège, Adrien ULg; Nicolay, Samuel ULg

Conference (2014, May 22)

We use the discrete "wavelet transform microscope" to show that the surface air temperature signals of weather stations selected in Europe are monofractal. This study reveals that the information obtained ... [more ▼]

We use the discrete "wavelet transform microscope" to show that the surface air temperature signals of weather stations selected in Europe are monofractal. This study reveals that the information obtained in this way are richer than previous works studying long range correlations in meteorological stations. The approach presented here allows to bind the Hölder exponents with the climate variability. We also establish that such a link does not exist with methods previously carried out, such as the detrended fluctuation analysis. [less ▲]

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See detailMultifractal analysis of the divergence of wavelet series
Esser, Céline ULg

Conference (2016, June 07)

In this talk, we study pointwise divergence properties of wavelet expansions of functions in a given Besov space. We obtain deterministic upper bounds for the Hausdorff dimensions of the sets of points ... [more ▼]

In this talk, we study pointwise divergence properties of wavelet expansions of functions in a given Besov space. We obtain deterministic upper bounds for the Hausdorff dimensions of the sets of points where a given rate of divergence is observed, and we show that these bounds are generically (in the sense of Baire's categories) optimal. This gives a complement to the works done by F. Bayart and Y. Heurteaux in the case of Fourier series and by J.M. Aubry. [less ▲]

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See detailA multifractal formalism based on the Sν spaces: From theory to practice
Esser, Céline ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

E-print/Working paper (2014)

We present an implementation of a multifractal formalism based on the Sν spaces and show that it effectively gives the right Hölder spectrum in numerous cases. In particular, it allows to recover non ... [more ▼]

We present an implementation of a multifractal formalism based on the Sν spaces and show that it effectively gives the right Hölder spectrum in numerous cases. In particular, it allows to recover non-concave spectra, where other multifractal formalisms only lead to the concave hull of the spectra. [less ▲]

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See detailA multifractal formalism for non-concave and non-increasing spectra: the leaders profile method
Esser, Céline ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

in Applied & Computational Harmonic Analysis (in press)

We present an implementation of a multifractal formalism based on the types of histogram of wavelet leaders. This method yields non-concave spectra and is not limited to their increasing part. We show ... [more ▼]

We present an implementation of a multifractal formalism based on the types of histogram of wavelet leaders. This method yields non-concave spectra and is not limited to their increasing part. We show both from the theoretical and from the applied points of view that this approach is more e cient than the wavelet-based multifractal formalisms previously introduced. [less ▲]

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See detailMultifractal properties of pore-size distribution in apple tissue using X-ray imaging
Mendoza, Fernando; Verboven, Pieter; Ho, Quang Tri et al

in JOURNAL OF FOOD ENGINEERING (2010), 99(2), 206-215

The pore-size distribution (PSD) has an important influence on the complex gas transport phenomena (02 and CO(2)) that occur in apple tissue during storage under controlled atmosphere conditions. It ... [more ▼]

The pore-size distribution (PSD) has an important influence on the complex gas transport phenomena (02 and CO(2)) that occur in apple tissue during storage under controlled atmosphere conditions. It defines the apple tissue microstructure that is correlated to many other apple properties. In this article multifractal analysis (MFA) has been used to study the multiscale structure of the PSD using generalized dimensions in three varieties of apples (Jonagold, Greenstar, and Kanzi) based on X-ray imaging technology (8.5 mu m resolution). Tomographic images of apple samples were taken at two positions within the parenchyma tissue: close to the peel and near to the core. The images showed suitable scaling properties. The generalized dimensions were determined with an R(2) greater than 0.98 in the range of moment orders between -1 and +10. The variation of D(q) with respect to q and the shape of the multifractal generalized spectrum revealed that the PSD structure of apple tissue has properties close to multifractal self-similarity measures. Comparisons among cultivars showed that, in spite of the complexity and variability of the pore space of these apple samples, the extracted generalized dimensions from PSD were significantly different (p < 0.05). The generalized dimensions D(0), D(1), D(2), and the quantity D(0)-D(2) could be used to discriminate tissue samples from different positions or cultivars. Also, high correlations were found between these parameters and the porosity (R(2) >= 0.935). These results demonstrate that MFA is an appropriate tool for characterizing the internal pore-size distribution of apple tissue and thus may be used as a quantitative measure to understand how tissue microstructure affects important physical properties of apple. (C) 2010 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMultifractal wave functions of simple quantum maps
Martin, John ULg; Garcia-Mata, Ignacio; Giraud, Olivier et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010), 82

We study numerically multifractal properties of two models of one-dimensional quantum maps: a map with pseudointegrable dynamics and intermediate spectral statistics and a map with an Anderson-like ... [more ▼]

We study numerically multifractal properties of two models of one-dimensional quantum maps: a map with pseudointegrable dynamics and intermediate spectral statistics and a map with an Anderson-like transition recently implemented with cold atoms. Using extensive numerical simulations, we compute the multifractal exponents of quantum wave functions and study their properties, with the help of two different numerical methods used for classical multifractal systems (box-counting and wavelet methods). We compare the results of the two methods over a wide range of values. We show that the wave functions of the Anderson map display a multifractal behavior similar to eigenfunctions of the three-dimensional Anderson transition but of a weaker type. Wave functions of the intermediate map share some common properties with eigenfunctions at the Anderson transition (two sets of multifractal exponents, with similar asymptotic behavior), but other properties are markedly different (large linear regime for multifractal exponents even for strong multifractality, different distributions of moments of wave functions, and absence of symmetry of the exponents). Our results thus indicate that the intermediate map presents original properties, different from certain characteristics of the Anderson transition derived from the nonlinear sigma model. We also discuss the importance of finite-size effects. [less ▲]

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See detailA multifractal-based climate analysis
Deliège, Adrien ULg; Nicolay, Samuel ULg

Conference (2014, March 25)

This work consists of a multifractal analysis of surface air temperature in Western and Eastern Europe. The wavelet leaders method enables us to exhibit the monofractal nature of these signals. Then, we ... [more ▼]

This work consists of a multifractal analysis of surface air temperature in Western and Eastern Europe. The wavelet leaders method enables us to exhibit the monofractal nature of these signals. Then, we define a climate classification relying on the Zygmund-Hölder spaces and show that it matches the Köppen classification. By doing so, we evidence the existing relation between the regularity of the temperature data (obtained through functional spaces) and the type of climate. Finally, we give a climatic interpretation of these results. [less ▲]

Detailed reference viewed: 58 (25 ULg)