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See detailNew Insights into the Regulation and Function of Brain Estrogen Synthase (Aromatase)
Balthazart, Jacques ULg; Ball, G. F.

in Trends in Neurosciences (1998), 21(6), 243-9

In the brain, conversion of androgens into estrogens by the enzyme aromatase (estrogen synthase) is a key mechanism by which testosterone regulates many physiological and behavioral processes, including ... [more ▼]

In the brain, conversion of androgens into estrogens by the enzyme aromatase (estrogen synthase) is a key mechanism by which testosterone regulates many physiological and behavioral processes, including the activation of male sexual behavior, brain sexual differentiation and negative feedback effects of steroid hormones on gonadotropin secretion. Studies on the distribution and regulation of brain aromatase have led to a new perspective on the control and function of this enzyme. A growing body of evidence indicates that the estrogen regulation of aromatase is, at least in part, trans-synaptic. Afferent catecholamine pathways appear to regulate aromatase activity in some brain areas and thereby provide a way for environmental cues to modulate this enzyme.The localization of aromatase in pre-synaptic boutons suggests possible roles for estrogens at the synapse. [less ▲]

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See detailNew insights into the role of the pharyngeal jaw apparatus in the sound producing mechanism of Haemulon flavolineatum (Haemulidae)
Bertucci, Frédéric ULg; Ruppé, Laetitia; Van Wassenbergh, Sam et al

in Journal of Experimental Biology (2014), 217

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See detailNew insights into the transformation of carbohydrates into platform chemicals
Richel, Aurore ULg; Wathelet, Jean-Paul ULg; Paquot, Michel ULg

Poster (2010, October 14)

The synthesis of furanic compounds from carbohydrates has become exciting in chemistry and in catalysis studies, because it represents one of the major routes for achieving sustainable energy supply and ... [more ▼]

The synthesis of furanic compounds from carbohydrates has become exciting in chemistry and in catalysis studies, because it represents one of the major routes for achieving sustainable energy supply and chemicals production.1 In particular, 5-hydroxymethylfurfural (5-HMF) and 2-furfural (2-F) occupy a pivotal place and are recognised as versatile and multi-functional starting points for the synthesis of a panel of precursors. Microwaves have readily appeared as a powerfull technique for accelerating reaction rates and increasing selectivities in the field of carbohydrate chemistry.3 In particular, their involvment in combination with heterogeneous catalysts have opened new vistas in the production of bio-oxygenated platform chemicals. The state of the art and main outlook of this strategy are reported here. [less ▲]

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See detailNew Insights into Thymus Physiology
Geenen, Vincent ULg

Scientific conference (2013, November 08)

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See detailNew insights on the quasars central region from microlensed quasars
Sluse, Dominique ULg; Hutsemekers, Damien ULg; Wambsganss, Joachim et al

Conference (2012, March 21)

Our detailed understanding of the working engine of quasars is still incomplete. Several basic questions remain such as: How is the supermassive black hole in the center of quasars fed ? What is the ... [more ▼]

Our detailed understanding of the working engine of quasars is still incomplete. Several basic questions remain such as: How is the supermassive black hole in the center of quasars fed ? What is the geometry and kinematics of the gas flow near the black hole ? The slow advances in answering these questions during the last decades advocates for new research methods. The analysis of the microlensing-induced deformations of multiply-imaged quasars is one such technique. It starts to be used as a tool to measure the temperature profile of the accretion disk, to estimate the size and study the geometry of the region emitting the broad emission lines. However, up to now, these applications have concerned mostly a handful of systems. In this talk, I will discuss the occurence of microlensing in a sample known strongly-lensed quasars and present the variety of emission-line deformations which is observed. I will also explain how spectroscopic follow-up of strongly-lensed quasars in the survey era should provide important insights on the quasar structure. [less ▲]

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See detailNew insights on the role of root radial conductivity on the overall uptake dynamics
Lobet, Guillaume ULg; Javaux, M.; Couvreur, V. et al

Conference (2011)

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See detailNew insights on the role of root radial hydraulic conductivity in the overall water uptake process
Lobet, Guillaume ULg; Draye, X.

in Communications in Agricultural and Applied Biological Sciences (2012), 77(1), 117--122

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See detailNew insights to the pathogenesis of acute pulmonary edema in patients with ischaemic left ventricular dysfunction: role of dynamic mitral regurgitation
Lancellotti, Patrizio ULg; Bauer, C.; Stainier, P. Y. et al

in European Heart Journal (2004), 25(Suppl. S), 589

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See detailNew insignts in preeclampsia : Is early prediction possible?
Munaut, Carine ULg

Scientific conference (2009, December 16)

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See detailNew institutional economic theories of non-profits and cooperatives: a critique from an evolutionary perspective
Bauwens, Thomas ULg

E-print/Working paper (2013)

Traditional economic theories of social enterprises rely on new institutional economics. Although these theories have an undeniable explanatory power, they display a series of non-negligible flaws ... [more ▼]

Traditional economic theories of social enterprises rely on new institutional economics. Although these theories have an undeniable explanatory power, they display a series of non-negligible flaws. Evolutionary and complexity approaches in economics may help overcome these limits. The object of this article is, in a first time, to review the different new institutional theories applied to non-profits and cooperatives and, in a second time, to present some criticisms addressed to new institutional economics. We concentrate on two controversial aspects of the latter: on the one hand, its underlying hypotheses about individuals and, in particular, bounded rationality and opportunism; on the other hand, its neglect of the emergent and evolving nature of economic phenomena and of the importance of history and the environment in agents’ institutional choices. For each criticism, we make proposals, mainly inspired by evolutionary and complexity approaches in economics, in order to overcome these limits. [less ▲]

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See detailNew INTEGRAL Observations of η Carinae Close to Periastron
Leyder, J.-C.; Walter, R.; Rauw, Grégor ULg

in Astronomical Society of the Pacific Conference Series (2013, January 01)

The soft X-ray thermal emission of η Carinae varies strongly around the periastron, following the orbital period of 5.5 yr. We studied the hard X-ray non-thermal emission of η Car using new INTEGRAL ... [more ▼]

The soft X-ray thermal emission of η Carinae varies strongly around the periastron, following the orbital period of 5.5 yr. We studied the hard X-ray non-thermal emission of η Car using new INTEGRAL observations taken close to periastron. We showed that the hard X-ray emission is very likely to be associated with η Car, and not with any other source found within the INTEGRAL error circle. We also showed that the 3-σ detection during the soft X-ray minimum is consistent with a hydrogen column density that does not exceed 6×10[SUP]23[/SUP] cm[SUP]-2[/SUP]. [less ▲]

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See detailNew integrated bioprocess for the continuous production, extraction and purification of lipopeptides produced by Bacillus subtilis in membrane bioreactor.
COUTTE, F.; LECOUTURIER, D.; LECLÈRE, V. et al

in Process Biochemistry (2013), 48

Recently, a bubbleless membrane bioreactor (BMBR) has been successfully developed for biosurfactant production by Bacillus subtilis [1]. In this study, for the first time, continuous culture were carried ... [more ▼]

Recently, a bubbleless membrane bioreactor (BMBR) has been successfully developed for biosurfactant production by Bacillus subtilis [1]. In this study, for the first time, continuous culture were carried out for the production of surfactin in a BMBR, both with or without a coupled microfiltration membrane. Results from continuous culture showed that a significant part of biomass was immobilized onto the air/liquid membrane contactor. Immobilized biomass activity onto the air/liquid membrane contactor was monitored using a respirometric analysis. Kinetics of growth, surfactin and primary metabolites production were investigated. Planktonic biomass, immobilized biomass and surfactin production and productivity obtained in batch culture (3 L) of 1.5 days of culture were 4.5 g DW, 1.3 g DW, 1.8 g and 17.4 mg L−1 h−1, respectively. In continuous culture without total cell recycling (TCR), the planktonic biomass was leached, but immobilized biomass reached a steady state at an estimated 6.6 g DW. 11.5 g of surfactin was produced after 3 days of culture, this gave an average surfactin productivity of 54.7 mg L−1 h−1 for the continuous culture, which presented a surfactin productivity of 30 mg L−1 h−1 at the steady state. TCR was then investigated for the continuous production, extraction and purification of surfactin using a coupled ultrafiltration step. In continuous culture with TCR at a dilution rate of 0.1 h−1, planktonic biomass, immobilized biomass, surfactin production and productivity reached 7.5 g DW, 5.5 g DW, 7.1 g and 41.6 mg L−1 h−1 respectively, after 2 days of culture. After this time, biomass and surfactin productions stopped. Increasing dilution rate to 0.2 h−1 led to the resumption of biomass and surfactin production and these values reached 11.1 g DW, 10.5 g DW, 7.9 g and 110.1 mg L−1 h−1, respectively, after 3 days of culture. This study has therefore shown that with this new integrated bioprocess, it was possible to continuously extract and purify several grams of biosurfactant, with purity up to 95%. [less ▲]

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See detailThe new integrated hydrological model MOHISE: construction, implementation and results
Carabin, G.; Brouyère, Serge ULg; Dassargues, Alain ULg et al

in Book of abstracts of the International Workshop on Catchment Scale Hydrologic Modeling and Data Assimilation (2001)

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See detailNew Integrated Tools to Improve the Traffic and the Port Planning
Rigo, Philippe ULg; Rodriguez, S.

in 29th PIANC International Congress (1999)

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See detailNew integrative method to generate Bacillus subtilis recombinant strains free of selection markers
Brans, Alain ULg; Filée, Patrice ULg; Chevigné, Andy ULg et al

in Applied and Environmental Microbiology (2004), 70(12), 7241-7250

The novel method described in this paper combines the use of blaI, which encodes a repressor involved in Bacillus licheniformis BlaP beta-lactamase regulation, an antibiotic resistance gene, and a B ... [more ▼]

The novel method described in this paper combines the use of blaI, which encodes a repressor involved in Bacillus licheniformis BlaP beta-lactamase regulation, an antibiotic resistance gene, and a B. subtilis strain (BS1541) that is conditionally auxotrophic for lysine. We constructed a BlaI cassette containing blaI and the spectinomycin resistance genes and two short direct repeat DNA sequences, one at each extremity of the cassette. The BS1541 strain was obtained by replacing the B. subtilis P(lysA) promoter with that of the P(blaP) beta-lactamase promoter. In the resulting strain, the cloning of the blaI repressor gene confers lysine auxotrophy to BS1541. After integration of the BlaI cassette into the chromosome of a conditionally lys-auxotrophic (BS1541) strain by homologous recombination and positive selection for spectinomycin resistance, the eviction of the BlaI cassette was achieved by single crossover between the two short direct repeat sequences. This strategy was successfully used to inactivate a single gene and to introduce a gene of interest in the Bacillus chromosome. In both cases the resulting strains are free of selection marker. This allows the use of the BlaI cassette to repeatedly further modify the Bacillus chromosome. [less ▲]

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