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See detailRégulation de l'expression de l'oncogène c-erbB2 dans les cancers mammaires humains.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

Conference (1994, May 06)

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See detailRégulation de l’expression de la nestine par les cellules souches mésenchymateuses en culture
Wislet-Gendebien, Sabine ULg

Master of advanced studies dissertation (2002)

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See detailLa régulation de l'expression des gènes du virus de la varicelle et du zona
Piette, Jacques ULg; Defechereux, Patricia; Baudoux, Laurence et al

in Annales de Médecine Vétérinaire (1992), 136(8), 627-635

Varicella-zoster virus (VZV) belongs to the alphaherpesvirus family and shares many important structural and functional similarities with other members of the family such as herpes simplex virus type 1 ... [more ▼]

Varicella-zoster virus (VZV) belongs to the alphaherpesvirus family and shares many important structural and functional similarities with other members of the family such as herpes simplex virus type 1 (HSV-1). VZV is responsible for two different clinical syndromes, varicella which is the result of the primary infection and zoster which is due to virus reactivation remaining latent in the peripheral nervous system. VZV DNA is 124,884 base pair long and encodes four regulatory proteins (IE4, IE61, IE62 and IE63). Using transient expression systems, we have shown that IE4, IE62 and IE63 can regulate the expression of an indicator gene driven by various VZV promoter regions, demonstrating that these proteins play important roles in the infectious cycle. [less ▲]

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See detailREGULATION DE L'EXPRESSION ET DE LA REPLICATION DU VIRUS T-LYMPHOTROPE HUMAIN DE TYPE I (HTLV-1) PAR LE COMPLEXE MINICHROMOSOME MAINTENANCE 2-7 (MCM2-7)
Barez, Pierre-Yves ULg

Master's dissertation (2011)

First human retrovirus discovered, HTLV-1 infects approximately 20 million individuals worldwide. HTLV-1 is the etiological agent of adult T-cell leukemia and a neurodegenerative disorder called HAM/TSP ... [more ▼]

First human retrovirus discovered, HTLV-1 infects approximately 20 million individuals worldwide. HTLV-1 is the etiological agent of adult T-cell leukemia and a neurodegenerative disorder called HAM/TSP (HTLV-1 associated myelopathy/Tropical spastic paraparesis). The MCM2-7 complex seems to play a key role in the biology of viruses, such as EBV (Epstein-Barr virus), KSHV (Kaposi’s sarcoma associated virus) or Influenza. This is also the case for HTLV-1 virus because we revealed the recruitment of MCM2-7 onto the viral promoter. The role of this interaction does not pertain to viral replication but is involved in transcriptional regulation. In fact, overexpression of MCM3 increases Tax transactivation activity dependently on Tax/MCM3 interaction and MCM3 carboxy-terminal domain. Finally, our observations indicate that MCM3 is likely required for Tax nuclear shuttling. This work thus gives insights into new mechanisms by which Tax ensures the viral persistence and leads to the development of HTLV-1 associated diseases. [less ▲]

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See detailRegulation de la croissance folliculaire et lutéale. 2. Ovulation, corps jaune et lutéolyse
Drion, Pierre ULg; Ectors, Fabien; Hanzen, Christian ULg et al

in Point Vétérinaire (1996), 28

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See detailRégulation de la croissance folliculaire et lutéale: 2. Ovulation, corps jaune et lutéolyse
Drion, Pierre ULg; Ectors, Fabien ULg; Houtain, J. Y. et al

in Point Vétérinaire (1996), 28

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See detailRégulation de la synthèse de cytokines pro-inflammatoires par l’oxyde nitrique (NO)
Henrotin, Yves ULg; Zheng, X; Deby, G et al

in Revue du Rhumatisme (1997), 64(11), 763

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See detailLa régulation de la temperature chez les animaux à sang chaud
Fredericq, Léon ULg

in Revue Scientifique (1880)

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See detailLa régulation des cycles infectieux du virus de la varicelle et du zona
Piette, Jacques ULg; Defechereux-Thibaut de Maisières, Patricia; Baudoux-Tebache, Laurence et al

in M S-Médecine Sciences (1998), 14(5), 556-565

Varicella-zoster virus (VZV) is an Alphaherpesvirus responsible for two human diseases: primary exposure to the virus results in chicken pox (varicella) and reactivation following a period of latency in ... [more ▼]

Varicella-zoster virus (VZV) is an Alphaherpesvirus responsible for two human diseases: primary exposure to the virus results in chicken pox (varicella) and reactivation following a period of latency in dorsal lia gives rise to shingles (zoster). Interestingly, several transcripts corresponding to regulatory proteins present during the lytic cycle can be found in latently infected cells. The IE62 protein, component of the viral tegument, is a nuclear phosphoprotein. IE62 may play a crucial role in triggering and regulating the replicative cycle of VZV since it transactivates all classes of VZV genes and is able to repress or activate its own promoter. Moreover, IE62 acts in synergy with IE4, another important regulatory protein, to stimulate VZV gene promoters and IE62 is responsible for the translocation of IE4 from the cytoplasm to the nucleus. IE4 is expressed at very early times of the VZV productive cycle, Predominantly localized in the cytoplasm, IE4 activates several VZV genes, either alone or in synergy with IE62, as well as heterologous viral genes. At the molecular level, IE4 seems to act both transcriptionally and post-transcriptionally. Another major VZV protein is a 45 kDa phosphorylated protein, called IE63, which is abundantly expressed at the onset of the productive cycle. It is also defected during latency in humans and in a rat animal model an unexpected observation in Alphaherpesviruses. IE63 displays little direct effect on VZV gene promoters, it shows no inhibitory effect on the transactivating functions of IE62 but it represses the IE4 mediated activation. Studies conducted to define the mode of action of three VZV regulatory proteins playing crucial roles in the latency and reactivation of the am-rus mil not only lead to a better understanding of the virus pathogenesis but will probably help define novel therapeutic tools. [less ▲]

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See detailLa régulation des industries de réseau en Belgique
de Streel, Alexandre; Gautier, Axel ULg; Wauthy, Xavier

in Reflets et Perspectives de la Vie Economique (2011), L(3), 73-92

Le bilan que l’on peut dresser concernant la libéralisation et le nouveau mode de régulation des industries de réseau en Belgique est assez mitigé. En particulier, les bénéfices issus de la libéralisation ... [more ▼]

Le bilan que l’on peut dresser concernant la libéralisation et le nouveau mode de régulation des industries de réseau en Belgique est assez mitigé. En particulier, les bénéfices issus de la libéralisation tardent à être transférés vers les utilisateurs finaux et le financement des investissements nécessaires aux gains d’efficacité dynamiques n’est parfois pas assez facilité par l’action des régulateurs. Dans cet article, nous analysons tout d’abord d’un point de vue général, les enjeux et les difficultés auxquels les autorités de régulation sont confrontés et ensuite nous identifions quelques éléments critiques, spécifiques à trois industries : l’électricité, les télécommunications, et le transport de fret ferroviaire. En conclusion nous insistons sur la nécessité d’une indépendance accrue des régulateurs, un énoncé plus clair de leurs orientations stratégiques et une simplification institutionnelle. Ces trois conditions nous semblent indispensables pour assurer la sécurité juridique nécessaire à la réalisation optimale des investissements nécessaires dans les infrastructures. Par ailleurs, dans certains cas, une intégration européenne plus poussée est justifiée. [less ▲]

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See detailLa régulation des services publics: les enseignements du droit comparé
Thirion, Nicolas ULg

in Chroniques de Droit Public = Publiekrechtelijke Kronieken (2002), 4

Detailed reference viewed: 27 (10 ULg)
See detailLa régulation des télécommunications: une antichambre du droit antitrust?
Thirion, Nicolas ULg

in Thirion, Nicolas; Peltzer, Patrick (Eds.) La régulation économique dans la vie des affaires (2007)

Etude destinée à présenter le processus de libéralisation / régulation du secteur des communications électroniques en Europe depuis la fin des années 1980

Detailed reference viewed: 48 (7 ULg)
See detailRégulation du magnésium
Krzesinski, Jean-Marie ULg

Conference (2011, November 29)

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See detailRégulation du Métabolisme des Chondrocytes par l'Oncostatine M et l'Interleukine 6
Sanchez, Christelle ULg; Deberg, Michelle ULg; Devel, Philippe et al

in Revue du Rhumatisme (2004), 71(10-11), 1008

Detailed reference viewed: 23 (4 ULg)
See detailRégulation du phosphore
Krzesinski, Jean-Marie ULg

Conference (2011, December 20)

Detailed reference viewed: 10 (3 ULg)
See detailRégulation du potassium
Krzesinski, Jean-Marie ULg

Conference (2011, October 25)

Detailed reference viewed: 10 (1 ULg)