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See detailPrevention of postmenopausal osteoporosis with pharmacological therapy: practice and possibilities
Reginster, Jean-Yves ULg

in Journal of Internal Medicine (2004), 255(6), 615-628

Postmenopausal osteoporosis (PMO) is a common disease that will become more prevalent in the future, with costly implications for public health. Prevention of the disease and its consequences, namely ... [more ▼]

Postmenopausal osteoporosis (PMO) is a common disease that will become more prevalent in the future, with costly implications for public health. Prevention of the disease and its consequences, namely fractures, is therefore, important for both the individual and society. This review discusses: the goals of PMO prevention; the identification of women at risk, including the use of bone mineral density and bone turnover markers; the relevance in the prevention setting of various current guidelines for PMO management; recent data on therapeutic options for the treatment and prevention of PMO, in particular bisphosphonates, hormone replacement therapy and several other new pharmacological agents. It concludes that it is crucial for PMO prevention to start before disease onset and that, in the light of recent evidence, the existing guidelines need updating if they are to continue to be relevant. [less ▲]

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See detailPrevention of Reflective Cracking in Pavements (Chapter 4)
Courard, Luc ULg; Vanelstraete, A.; de Bondt, A. et al

in • Characterization of overlay systems (1997)

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See detailPrevention of spectators’ violence and safety in football stadiums
Comeron, Manuel ULg

Scientific conference (2007, May 30)

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See detailThe prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP.
Goval, Jean-Jacques; Thielen, Caroline ULg; Bourguignon, Caroline et al

in Haematologica (2008), 93(8), 1169-77

BACKGROUND: Follicular lymphoma, the neoplastic counterpart of germinal center B cells, typically recapitulates a follicular architecture. Several observations point to the crucial role of the cellular ... [more ▼]

BACKGROUND: Follicular lymphoma, the neoplastic counterpart of germinal center B cells, typically recapitulates a follicular architecture. Several observations point to the crucial role of the cellular microenvironment in the development and/or progression of follicular lymphoma cells in vivo. The aim of our study was to characterize the spontaneous apoptosis of follicular lymphoma cells in vitro, and the modulation of this apoptosis by follicular dendritic cells. DESIGN AND METHODS: We used a cell line derived from follicular dendritic cells to model the functional interactions of these cells and lymphoma cells in co-culture. Follicular lymphoma cells were isolated from tissue biopsies. Apoptosis was quantified by flow cytometry and apoptotic pathways were investigated by western blotting. RESULTS: The spontaneous apoptosis of follicular lymphoma cells in vitro involves the activation of caspases-3 and -8 but not of caspase-9, occurs despite persistent high levels of BCL-2 and MCL-1, and is associated with down-regulation of c-FLIP(L). Spontaneous apoptosis of follicular lymphoma cells is partially prevented by co-culture with the follicular dendritic cells, which prevents activation of caspase-8, caspase-3 and induces an upregulation of c-FLIP(L). Using neutralizing antibodies, we demonstrated that interactions involving CD54 (ICAM-1), CD106 (VCAM-1) and CD40 are implicated in this biological process. CONCLUSIONS: Follicular dendritic cells constitute a useful tool to study the functional interactions between follicular lymphoma cells and follicular dendritic cells in vitro. Understanding the molecular mechanisms involved in these protective interactions may lead to the identification of therapeutic agents that might suppress the survival and growth of follicular lymphoma cells. [less ▲]

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See detailPrevention of type 2 diabetes mellitus through inhibition of the Renin-Angiotensin system.
Scheen, André ULg

in Drugs (2004), 64(22), 2537-65

Type 2 diabetes mellitus is becoming a major health problem associated with excess morbidity and mortality. As the prevalence of type 2 diabetes is rapidly increasing, prevention of the disease should be ... [more ▼]

Type 2 diabetes mellitus is becoming a major health problem associated with excess morbidity and mortality. As the prevalence of type 2 diabetes is rapidly increasing, prevention of the disease should be considered as a key objective in the near future. Besides lifestyle changes, various pharmacological treatments have proven their efficacy in placebo-controlled clinical trials, including antidiabetic drugs such as metformin, acarbose and troglitazone, or antiobesity agents such as orlistat. Arterial hypertension, a clinical entity in which insulin resistance is common, is strongly associated with type 2 diabetes and may precede the disease by several years. While antihypertensive agents such as diuretics or beta-adrenoceptor antagonists may worsen insulin resistance and impair glucose tolerance, newer antihypertensive agents exert neutral or even slightly positive metabolic effects. Numerous clinical trials have investigated the effects of ACE inhibitors or angiotensin II receptor antagonists (ARAs) on insulin sensitivity in hypertensive patients, with or without diabetes, with no consistent results. Almost half of the studies with ACE inhibitors in hypertensive nondiabetic individuals demonstrated a slight but significant increase in insulin sensitivity as assessed by insulin-stimulated glucose disposal during a euglycaemic hyperinsulinaemic clamp, while the other half failed to reveal any significant change. The effects of ARAs on insulin sensitivity are neutral in most studies. Mechanisms of improvement of glucose tolerance and insulin sensitivity through the inhibition of the renin-angiotensin system (RAS) are complex. They may include improvement of blood flow and microcirculation in skeletal muscles and, thereby, enhancement of insulin and glucose delivery to the insulin-sensitive tissues, facilitating insulin signalling at the cellular level and improvement of insulin secretion by the beta cells. Six recent large-scale clinical studies reported a remarkably consistent reduction in the incidence of type 2 diabetes in hypertensive patients treated with either ACE inhibitors or ARAs for 3-6 years, compared with a thiazide diuretic, beta-adrenoceptor antagonist, the calcium channel antagonist amlodipine or even placebo. The relative risk reduction averaged 14% (p = 0.034) in the CAPPP (Captopril Prevention Project) with captopril compared with a thiazide or beta1-adrenoceptor antagonist, 34% (p < 0.001) in the HOPE (Heart Outcomes Prevention Evaluation) study with ramipril compared with placebo, 30% (p < 0.001) in the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) with lisinopril compared with chlortalidone, 25% (p < 0.001) in the LIFE (Losartan Intervention For Endpoint reduction in hypertension study) with losartan compared with atenolol, and 25% (p = 0.09) in the SCOPE (Study on Cognition and Prognosis in the Elderly) with candesartan cilexetil compared with placebo, and 23% (p < 0.0001) in the VALUE (Valsartan Antihypertensive Long-term Use Evaluation) trial with valsartan compared with amlodipine. All these studies considered the development of diabetes as a secondary endpoint, except the HOPE trial where it was a post hoc analysis. These encouraging observations led to the initiation of two large, prospective, placebo-controlled randomised clinical trials whose primary outcome is the prevention of type 2 diabetes: the DREAM (Diabetes REduction Approaches with ramipril and rosiglitazone Medications) trial with the ACE inhibitor ramipril and the NAVIGATOR (Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research) trial with the ARA valsartan. Finally, ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) will also investigate as a secondary endpoint whether it is possible to prevent the development of type 2 diabetes by blocking the RAS with either an ACE inhibitor or an ARA or a combination of both. Thus, the recent consistent observations of a 14-34% reduction of the development of diabetes in hypertensive patients receiving ACE inhibitors or ARAs are exciting. From a theoretical point of view, they emphasise that there are many aspects of the pathogenesis, prevention and treatment of type 2 diabetes that still need to be uncovered. From a practical point of view, they may offer a new strategy to reduce the ongoing epidemic and burden of type 2 diabetes. [less ▲]

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See detailPrevention of violence in football stadiums in Europe
Comeron, Manuel ULg; Kellens, Georges ULg; Vanbellingen, Pierre

Book published by asbl Fan coaching-Eurofan (2002)

Exchanges about European practices of hooliganism prevention and sharing of scientific studies about this phenomenon in Europe.

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See detailThe prevention of violence in sport
Comeron, Manuel ULg

Book published by Coucil of Europe Publishing (2003)

The beginning of this century has seen a shift in the type of violence associated with sports events, in particular football. Once contained by football grounds and generally one-off and spontaneous in ... [more ▼]

The beginning of this century has seen a shift in the type of violence associated with sports events, in particular football. Once contained by football grounds and generally one-off and spontaneous in nature, sports violence has moved to urban areas and city centres. Contemporary society is now confronted with sports violence which is often premeditated, and commonly involves hard-core supporters who seek systematic and organised confrontation at local, national and international matches and tournaments. As hooliganism becomes international, generating similar problems in Europe and throughout the world, a common and concerted preventive response at international level is needed. The prevention of violence in sport proposes actions and structures based on experiments in progress which have already shown some degree of effectiveness. These initiatives open up a range of solutions for developing integrated preventive activities of a high standard that can be adapted to local needs. [less ▲]

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See detailPrevention of violence in the sports area: social and educative measures
Comeron, Manuel ULg

Conference (2004, January 23)

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See detailPrevention of vocal folds' scars:microsurgical principles
FINCK, Camille ULg

Conference (2011, December)

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See detailLa prévention par le droit. Territoires et division du travail juridique en France
Lejeune, Aude ULg

in SociologieS (2010)

In a way to promote access to justice and legal services for disadvantaged people, French Justice Department created a new kind of occupation: proximity lawyers. This article analyses how traditional ... [more ▼]

In a way to promote access to justice and legal services for disadvantaged people, French Justice Department created a new kind of occupation: proximity lawyers. This article analyses how traditional lawyers and proximity lawyers negotiate the division of work, as well as how it reshapes relationships between national Justice Department and the states (collectivités territoriales). [less ▲]

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See detailPrévention primaire des maladies rénales
Krzesinski, Jean-Marie ULg

Learning material (2003)

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See detailPrévention primaire des maladies rénales et secondaire de l'insuffisance rénale
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Médi-Sphère (2003), 192

Il est apparu important de rèsumer les points capitaux à respecter lors de tout contact avec un patient, d'une part pour le proteger du développement de la maladie rénale (si possible) et pour freiner l ... [more ▼]

Il est apparu important de rèsumer les points capitaux à respecter lors de tout contact avec un patient, d'une part pour le proteger du développement de la maladie rénale (si possible) et pour freiner l'évolution de celle-ci une fois constituée d'autre part, l'objectif étant alors d'éviter l'insuffisance rénale sévère, stade où l'intervention du médecin n'est plus que symptomatique. Généralement fortuite, l'insuffisance rénale gagne à être diagnostiquée précocement. L'intervention du néphrologue sera également d'autant plus efficace que rapide. [less ▲]

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See detailPrevention primaire et secondaire du cancer colorectal
Polus, Marc ULg; Piront, Patricia ULg; Jerusalem, Guy ULg et al

in Revue Médicale de Liège (2003), 58(4), 247-53

Colorectal cancer is really a public health problem. The authors review the literature about the environmental factors leading to colorectal cancer. Chemoprevention of colorectal cancer is also discussed ... [more ▼]

Colorectal cancer is really a public health problem. The authors review the literature about the environmental factors leading to colorectal cancer. Chemoprevention of colorectal cancer is also discussed, particularly by aspirin and non steroidal anti-inflammatory drugs. Development of specific cyclooxygenase-2 inhibitors constitutes a promising research's field. Secondary prevention by coloscopy and polypectomy must lead to a lower rate of colorectal cancer disease and improvement of mortality. [less ▲]

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See detailPrévention quaternaire : agir est-il toujours justifié en médecine de famille ?
Widmer, Daniel; Herzig, Lilly; Jamoulle, Marc ULg

in Revue Médicale Suisse (2014), 10(430), 1052-6

La prévention quaternaire vise à protéger le patient ou la po- pulation de la surmédicalisation. Elle imprègne toute l’activité du médecin de famille par une interrogation tant sur l’utilité de la ... [more ▼]

La prévention quaternaire vise à protéger le patient ou la po- pulation de la surmédicalisation. Elle imprègne toute l’activité du médecin de famille par une interrogation tant sur l’utilité de la prévention primaire que du diagnostic précoce, ou sur les risques de la création de nouvelles entités pathologiques et d’une médecine maximaliste. Le médecin de famille favorise la prévention quaternaire en se centrant sur les priorités du patient et sur les ressources locales d’un système de soins efficace. [less ▲]

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See detailPrevention secondaire apres syndrome coronarien aigu
Legrand, Victor ULg; Gach, Olivier ULg; Martinez, Christophe ULg

in Revue Médicale de Liège (2003), 58(5), 279-82

Acute coronary syndromes are a major health care problem which remains associated with high rates of mortality, myocardial infarction and rehospitalisation after hospital discharge for acute treatment ... [more ▼]

Acute coronary syndromes are a major health care problem which remains associated with high rates of mortality, myocardial infarction and rehospitalisation after hospital discharge for acute treatment. The general practitioner has a critical role in the management of these patients. Physicians have to ensure an adequate control of all coronary risk factors. Systematic use of statines and aspirin is recommended. Also, the use of clopidogrel, fibrates, beta blockers and ACE inhibitors should be considered in some circumstances. Conversely, hormone replacement therapy in women, antioxydants and nitrates in the absence of angina are ineffective. [less ▲]

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See detailPrevention secondaire des accidents ischemiques coronariens par la chirurgie de pontage aorto-coronaire
Radermecker, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2003), 58(5), 283-6

Coronary artery bypass surgery has shown its superiority on other therapeutic options in specific but frequent indications such as left main lesions, multivessel disease with alteration of ventricular ... [more ▼]

Coronary artery bypass surgery has shown its superiority on other therapeutic options in specific but frequent indications such as left main lesions, multivessel disease with alteration of ventricular function, proximal lesions of the LAD, and multivessel diseases in diabetic patients. After reviewing the epidemiology of coronary artherosclerosis, we emphasize the efficacy of the surgical treatment compared to medical or interventional therapy for preventing ischemic events. The results derived from randomized studies may be even further improved by the implementation of beating heart surgery and the systematic use of multiple arterial conduits. [less ▲]

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See detailPrévention tertiaire de l'insuffisance rénale chronique chez l'adulte
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Médi-Sphère (2003), 197

L'insutfisance rénale chronique est une maladie méconnue, insidieuse, qui présente souvent peu je symptômes au début. Cet article veut insister sur les règles de bonne pratique pour freiner ou mieux ... [more ▼]

L'insutfisance rénale chronique est une maladie méconnue, insidieuse, qui présente souvent peu je symptômes au début. Cet article veut insister sur les règles de bonne pratique pour freiner ou mieux prévenir les complications de l'urémie et préparer si nécessaire le malade au traitement de suppléance. [less ▲]

Detailed reference viewed: 24 (0 ULg)