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See detailLes régulateurs de croissance
Vancutsem, Françoise ULg; Monfort, Bruno; Bodson, Bernard ULg et al

in Livre Blanc: Céréales - Gembloux (2007, February 28)

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See detailLes régulateurs de croissance
Vancutsem, Françoise ULg; Monfort, Bruno; Bodson, Bernard ULg

Conference given outside the academic context (2008)

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See detailLes régulateurs de croissance
Vancutsem, Françoise ULg; Seutin, Benoit ULg; Monfort, Bruno et al

in Livre Blanc: Céréales - Gembloux (2010, February 24)

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See detailLes régulateurs de croissance
Vancutsem, Françoise ULg; Seutin, Benoit ULg; Monfort, Bruno et al

in Livre Blanc: Céréales - Gembloux (2009, February 18)

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See detailRegulating a monopolist with limited funds
Gautier, Axel ULg; Mitra, Manipushpak

in Economic Theory (2006), 27

We consider the problem of regulating a monopolist with unknown costs when the regulator has limited funds. The optimal regulatory mechanism sat- isfies four properties. The first property is bunching at ... [more ▼]

We consider the problem of regulating a monopolist with unknown costs when the regulator has limited funds. The optimal regulatory mechanism sat- isfies four properties. The first property is bunching at the top, that is the more efficient types produce the same quantity irrespective of their costs. The second property is separability of less efficient types. The third property is full bunching of types when the available fund is small enough. The fourth property of the mecha- nism is that it is a third best one, that is, the output under this regulatory mechanism is strictly lower than the second best output for any given type. [less ▲]

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See detailRegulating safety behaviour : job-related effects and perceived safety climate.
Hansez, Isabelle ULg; Chmiel, N.

Conference (2008, January 11)

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See detailRégulation autocrine et paracrine de la production de protéoglycanes cartilagineux
Franchimont, P; Bassleer, C; Henrotin, Yves ULg

in Gaucher, P; Netter, P; Régent, D (Eds.) et al Actualités en physiopathologie et pharmacologie articulaires (1992)

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See detailRegulation by androgens of EGF receptor family members in prostate cancer cells
Pignon, Jean-Christophe; Delacroix, Laurence ULg; Waltregny, David ULg et al

in Proceedings of the American Association for Cancer Research (2006)

After an initial positive response to anti-androgen treatment, prostate cancer (PCa) cells usually become hormone-refractory in spite of their persistent expression of the androgen receptor (AR ... [more ▼]

After an initial positive response to anti-androgen treatment, prostate cancer (PCa) cells usually become hormone-refractory in spite of their persistent expression of the androgen receptor (AR). Overexpression of tyrosine kinase receptors in androgen-deprived PCa cells, such as those of the EGF receptor (EGFR) family, may be responsible for AR activation and growth of androgen-deprived tumours. Our goal is to understand the control of the expression of the EGFR family members by androgens in PCa. Hormone response was compared in hormone-sensitive LNCaP and hormone-insensitive DU145 PCa cell lines. These cells do not express ErbB4. EGFR, erbB2 and erbB3 protein half-life is much longer in DU145 than in LNCaP cells grown in complete medium. Dihydrotestosterone (DHT) modulates EGFR and erbB2 transcript and protein levels only in LNCaP cells. ErbB3 is not an androgen-responsive gene. EGFR mRNA and protein levels are increased while erbB2 mRNA and protein levels are decreased after DHT treatment of cells cultured in steroid-deprived medium. ErbB2 mRNA and protein levels are increased in LNCaP cells following DHT withdrawal. In order to understand the mechanisms by which androgens control the expression of EGFR and ERBB2 genes, half lifes of the corresponding mRNAs and proteins were compared in cells grown in presence or absence of DHT. The effect of DHT on EGFR gene expression is complex. Indeed, DHT stabilizes the protein. Moreover, a superinduction of EGFR mRNA was observed in cells treated with cycloheximide (CHX) before addition of the hormone, suggesting an effect on transcript stability. In contrast, erbB2 mRNA and protein stability was not affected by DHT. CHX treatment for 2h before addition of DHT suppresses the androgen-induced down-regulation of erbB2 mRNA levels. In summary, androgen-mediated regulation of EGFR and ERBB2 genes expression is complex. DHT influences EGFR gene transcription, mRNA and protein stability. DHT does not affect erbB2 mRNA and protein stability but acts indirectly on transcription. Current experiments are undertaken to verify these observations by Chromatin-IP experiments on both genes promoters. [less ▲]

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See detailRegulation by androgens of the expression of the EGF receptor family members in prostate cancer cells
Pignon, Jean-Christophe; Delacroix, Laurence; Nolens, Grégory et al

Conference (2007)

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See detailRegulation by reactive oxygen species (ROS) of interleukin-1 bêta, nitric oxide and prostaglandin E2 production by human chondrocytes
Henrotin, Yves ULg; Mathy-Hartert, M; Ayache, N et al

in Clinical Rheumatology (2001), 20

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See detailRegulation by reactive oxygen species of interleukin-1beta, nitric oxide and prostaglandin E(2) production by human chondrocytes.
Mathy, Marianne ULg; Deby, Ginette ULg; Reginster, Jean-Yves ULg et al

in Osteoarthritis and Cartilage (2002), 10(7), 547-55

OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2 ... [more ▼]

OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production by human chondrocytes. The effect of aceclofenac (ACECLO), a non-steroidal antiinflammatory drug (NSAID), was also examined. METHODS: Human chondrocytes were enzymatically isolated from osteoarthritic knee cartilage and then maintained in culture in suspension for 48h in the absence or in the presence of lipopolysaccharide (LPS) (10 microg/ml), L-NMMA (0.5mM), NAC (1mM) or ACECLO (6.10(-6)M). IL-1beta and PGE(2) productions were quantified by specific immunoassays. Nitrite was measured in the culture supernatants by a spectrophotometric method based upon the Griess reaction. Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction. COX-2 protein expression was analysed by Western blot. RESULTS: LPS markedly increased the expression of IL-1beta, iNOS and COX-2 genes. In parallel, NO(2) and PGE(2) amounts found in the culture supernatants were significantly enhanced whereas IL-1beta was immunologically undetectable. The addition of L-NMMA (0.5mM) fully blocked LPS-induced NO production but greatly increased PGE(2) production, suggesting a negative effect of NO on PGE(2) synthesis. Inversely, NO production was stimulated by NAC while PGE(2) production was not affected. Interestingly, NAC increased the IL-1beta and iNOS mRNA levels but did not significantly modify COX-2 mRNA expression. L-NMMA did not significantly affect the expression of IL-1beta, iNOS and COX-2. The amount of COX-2 protein did not change in the presence of the antioxidants. Finally, ACECLO fully blocked the production of PGE(2) by chondrocytes without affecting the levels of COX-2 mRNA. CONCLUSIONS: The stimulation of IL-1beta, NO and PGE(2) production by LPS is differentially controlled by reactive oxygen species (ROS). In fact, L-NMMA and NAC have different mechanisms of action on the regulation of NO and PGE(2) productions. L-NMMA fully inhibits NO but increases PGE(2) production whereas NAC up-regulates NO but does not modify PGE(2) synthesis. The stimulating effect of L-NMMA on PGE(2) production is not controlled at the transcriptional level. These findings suggest that antioxidant therapy could have different effects according to the oxygen radical species targeted. [less ▲]

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See detailRegulation by reactive oxygen species of pro-inflammatory genes in chondrocytes
Henrotin, Yves ULg; Mathy, Marianne ULg; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2002), 10(Suppl A), 34

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See detailLa régulation dans les télécommunications: une approche croisée de l'économie et du droit
Thirion, Nicolas ULg; Penard, Thierry

in Thirion, Nicolas (Ed.) Libéralisations, privatisations, régulations. Aspects juridiques et économiques des régulations sectorielles. Marchés financiers - Télécoms - Médias - Santé (2007)

Analyse croisée, sous les angles juridiques et économiques, du processus d'ouverture à la concurrence du secteur des télécommunications depuis la fin des années 1980, à la fois du point de vue de l'Union ... [more ▼]

Analyse croisée, sous les angles juridiques et économiques, du processus d'ouverture à la concurrence du secteur des télécommunications depuis la fin des années 1980, à la fois du point de vue de l'Union européenne et sous l'angle du modèle français [less ▲]

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See detailRégulation de l’activité des monooxygénases microsomales au cours de la croissance.
Gielen, Jacques; Kremers, Pierre ULg; Pasleau, Françoise ULg

in Les Colloques de l'INSERM, Pharmacologie du Développement (1979)

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See detailRégulation de l'expression de l'oncogène c-erbB2 dans les cancers mammaires humains.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

Conference (1994, May 06)

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See detailRégulation de l’expression de la nestine par les cellules souches mésenchymateuses en culture
Wislet-Gendebien, Sabine ULg

Master of advanced studies dissertation (2002)

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See detailLa régulation de l'expression des gènes du virus de la varicelle et du zona
Piette, Jacques ULg; Defechereux, Patricia; Baudoux, Laurence et al

in Annales de Médecine Vétérinaire (1992), 136(8), 627-635

Varicella-zoster virus (VZV) belongs to the alphaherpesvirus family and shares many important structural and functional similarities with other members of the family such as herpes simplex virus type 1 ... [more ▼]

Varicella-zoster virus (VZV) belongs to the alphaherpesvirus family and shares many important structural and functional similarities with other members of the family such as herpes simplex virus type 1 (HSV-1). VZV is responsible for two different clinical syndromes, varicella which is the result of the primary infection and zoster which is due to virus reactivation remaining latent in the peripheral nervous system. VZV DNA is 124,884 base pair long and encodes four regulatory proteins (IE4, IE61, IE62 and IE63). Using transient expression systems, we have shown that IE4, IE62 and IE63 can regulate the expression of an indicator gene driven by various VZV promoter regions, demonstrating that these proteins play important roles in the infectious cycle. [less ▲]

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See detailREGULATION DE L'EXPRESSION ET DE LA REPLICATION DU VIRUS T-LYMPHOTROPE HUMAIN DE TYPE I (HTLV-1) PAR LE COMPLEXE MINICHROMOSOME MAINTENANCE 2-7 (MCM2-7)
Barez, Pierre-Yves ULg

Master's dissertation (2011)

First human retrovirus discovered, HTLV-1 infects approximately 20 million individuals worldwide. HTLV-1 is the etiological agent of adult T-cell leukemia and a neurodegenerative disorder called HAM/TSP ... [more ▼]

First human retrovirus discovered, HTLV-1 infects approximately 20 million individuals worldwide. HTLV-1 is the etiological agent of adult T-cell leukemia and a neurodegenerative disorder called HAM/TSP (HTLV-1 associated myelopathy/Tropical spastic paraparesis). The MCM2-7 complex seems to play a key role in the biology of viruses, such as EBV (Epstein-Barr virus), KSHV (Kaposi’s sarcoma associated virus) or Influenza. This is also the case for HTLV-1 virus because we revealed the recruitment of MCM2-7 onto the viral promoter. The role of this interaction does not pertain to viral replication but is involved in transcriptional regulation. In fact, overexpression of MCM3 increases Tax transactivation activity dependently on Tax/MCM3 interaction and MCM3 carboxy-terminal domain. Finally, our observations indicate that MCM3 is likely required for Tax nuclear shuttling. This work thus gives insights into new mechanisms by which Tax ensures the viral persistence and leads to the development of HTLV-1 associated diseases. [less ▲]

Detailed reference viewed: 42 (20 ULg)