Syrie pré-hellénistique: Tell BeydarVan der Stede, Véronique ; ; in Annales d'Histoire de l'Art et d'Archéologie (1999), XXI Detailed reference viewed: 8 (1 ULg) Syrie pré-hellénistique: Tell BeydarVan der Stede, Véronique ; in Annales d'Histoire de l'Art et d'Archéologie (2001), XXIII Detailed reference viewed: 10 (1 ULg) System Analysis of a Programmed Cell Death ModelBullinger, Eric ![]() in IEEE Conference on Decision and Control (2005, December) Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this ... [more ▼] Apoptosis is a programmed cell death by which the organism removes unwanted cells. Its core reactions can be described by a system of differential equations exhibiting multiple steady-states. In this paper we analyse how this model can include both very slow dynamics for the lag phase before apoptosis (in theory up to several days) while the apoptosis itself is more switch-like with changes occurring within minutes. We both describe how the trajectories evolve during the lag phase and show which of the states have the most impact on the slow dynamics. [less ▲] Detailed reference viewed: 4 (1 ULg) System and control theory furthers the understanding of biological signal transductionBullinger, Eric ; ; et alin Queinnec, I.; Tarbouriech, S.; Garcia, G. (Eds.) et al Biology and Control Theory: Current Challenges (2008) This article discusses why novel modelling and analysis methods are required for biological systems, presents recent advances and outlines some future challenges. In this respect, the main focus is placed ... [more ▼] This article discusses why novel modelling and analysis methods are required for biological systems, presents recent advances and outlines some future challenges. In this respect, the main focus is placed upon methods for parameter estimation and sensitivity analysis as they are encountered in systems biology. [less ▲] Detailed reference viewed: 28 (3 ULg) A system evolution decomposition method: Application to the assessment of an operational forecasting system; Alvera Azcarate, Aïda ; Vandenbulcke, Luc et alConference (2004) Detailed reference viewed: 13 (3 ULg) System for color fusion, processing, 3D visualization, and mining of EO,IR, & SAR images, and of other multisensor or multispectral imagesVerly, Jacques ; ; et alConference (2002, June) Detailed reference viewed: 2 (0 ULg) A system for sex determination from degraded DNA: a useful tool for palaeogenetics and conservation genetics of ursidsPagès, Marie ; ; et alin Conservation Genetics (2009), 10 Abstract In this paper, we characterise three sex-specific genes (ZFX/Y, SRY, AMLX/Y) for all eight extant bear species and propose a new, robust and accurate molecular procedure to identify the sex of ... [more ▼] Abstract In this paper, we characterise three sex-specific genes (ZFX/Y, SRY, AMLX/Y) for all eight extant bear species and propose a new, robust and accurate molecular procedure to identify the sex of bears from non-invasive samples and fossil remains. These materials contain tiny amounts of poorly preserved deoxyribonucleic acid (DNA), leaving Polymerase Chain Reaction (PCR) amplification very prone to contamination and difficult to analyse. By taking into account the ancient DNA requirements, the duplex procedures that we developed are efficient not only on DNA extracted from bear faeces but also on ancient DNA extracted from a brown bear fossil 7,500 years old. Defined specifically for ursids, the procedure for faecal samples (co-amplification of ZFX/Y and SRY markers) appears more accurate than other published procedures, as it prevents cross-amplification of potential ingested prey and contamination (19 non-ursid species tested). This system can be applied to threatened bear populations to improve the reliability of sex-ratio and population-size estimates based on non-invasive samples. [less ▲] Detailed reference viewed: 9 (1 ULg) System Identification and Modeling of Biochemical SystemsBullinger, Eric ![]() Conference (2007, November) System Identification in Structural Dynamics Using Blind Source Separation TechniquesPoncelet, Fabien ; Kerschen, Gaëtan ; Golinval, Jean-Claude et alin 7th International Conference on ICA and Signal, Londres, 2007 (2007) This paper proposes to explore the potential of Blind Source Separation (BSS) techniques for the estimation of modal parameters, namely the resonant frequencies, vibration modes and damping ratios. The ... [more ▼] This paper proposes to explore the potential of Blind Source Separation (BSS) techniques for the estimation of modal parameters, namely the resonant frequencies, vibration modes and damping ratios. The concept of virtual sources, which was introduced in recent publications, allows to consider BSS as a simple way of doing output-only modal analysis. This work illustrates the proposed methodology using free and random responses of an experimental truss structure. [less ▲] Detailed reference viewed: 53 (10 ULg) The system of kallikrein-kininogens-kinins (KKK) and the acute-phase reactant proteins (APRP) in human undergoing extracorporeal circulation (ECC)Faymonville, Marie ; ; et alin Arnaud, P.; Bienvenu, J.; Laurent, P. (Eds.) Marker proteins in inflammation (1984) Detailed reference viewed: 9 (2 ULg) System optimization for residential SOFC 5 kW heat and electricity managementLilien, Jean-Louis ; ; (2004, July) A demonstration project will be presented using a 5 kW Solid Oxyde Fuel Cell for residential application in the region of Liège, Belgium. The current stage of the project is to evaluate the thermal ... [more ▼] A demonstration project will be presented using a 5 kW Solid Oxyde Fuel Cell for residential application in the region of Liège, Belgium. The current stage of the project is to evaluate the thermal management of a single house with, at the present time, 45 MW.h (thermal 25 MW.h, electrical 20 MW.h) annual consumptions. The changes needed from a classical gas boiler heating of 20 kW to a 6 kW (thermal) plus 5 kW (electrical) system will be studied and detailed. Evaluation of CO2 reduction in the two systems will be presented considering the Belgium mix of electricity production. The heat and electricity local storage to cover peak demand in both energy demands will be discussed in relation with a grid-connected fuel cell. In particular the detailed analysis of this home demand will be analysed for the last three years. An original thermal circuit will be proposed, including its regulation. The experimental result of the behaviour of our proposal during 2003-2004 winter will be presented using a “virtual” SOFC (actually replaced by “equivalent” 6 kWth boiler) which is intended to be used in the same environment after this testing period. Constrains related to SOFC typical behaviour will be taken into account in our proposal for regulation. Depending on our development, it may be possible that up-to-date results may be given at the conference with a real system using a true SOFC 5 kW which would be in service after Septembre 2004. [less ▲] Detailed reference viewed: 99 (4 ULg) System overview of the VLTI Spectro-Imager; ; et al in Schöller, Markus; Danchi, William; Delplancke, Françoise (Eds.) Optical and Infrared Interferometry (2008, July 01) The VLTI Spectro Imager project aims to perform imaging with a temporal resolution of 1 night and with a maximum angular resolution of 1 milliarcsecond, making best use of the Very Large Telescope ... [more ▼] The VLTI Spectro Imager project aims to perform imaging with a temporal resolution of 1 night and with a maximum angular resolution of 1 milliarcsecond, making best use of the Very Large Telescope Interferometer capabilities. To fulfill the scientific goals (see Garcia et. al.), the system requirements are: a) combining 4 to 6 beams; b) working in spectral bands J, H and K; c) spectral resolution from R= 100 to 12000; and d) internal fringe tracking on-axis, or off-axis when associated to the PRIMA dual-beam facility. The concept of VSI consists on 6 sub-systems: a common path distributing the light between the fringe tracker and the scientific instrument, the fringe tracker ensuring the co-phasing of the array, the scientific instrument delivering the interferometric observables and a calibration tool providing sources for internal alignment and interferometric calibrations. The two remaining sub-systems are the control system and the observation support software dedicated to the reduction of the interferometric data. This paper presents the global concept of VSI science path including the common path, the scientific instrument and the calibration tool. The scientific combination using a set of integrated optics multi-way beam combiners to provide high-stability visibility and closure phase measurements are also described. Finally we will address the performance budget of the global VSI instrument. The fringe tracker and scientific spectrograph will be shortly described. [less ▲] Detailed reference viewed: 4 (0 ULg) A System Understanding of TNF-α Induced Apoptotic and Antiapoptotic Signalling: Combining Single Cell and Population Modelling with Dynamic and Quantitative ExperimentsSchliemann, Monica ; ; Bullinger, Eric ![]() Poster (2009) Detailed reference viewed: 7 (0 ULg) A system-level modal description of flexible multibody dynamics; Bruls, Olivier ; in Proceedings of the 9th National Congress on Theoretical and Applied Mechanics (2009, May) Current modelling techniques only allow realtime simulation of strongly simplified models of flexible mechanisms. Both the number of degrees of freedom needed to accurately describe flexibility as the DAE ... [more ▼] Current modelling techniques only allow realtime simulation of strongly simplified models of flexible mechanisms. Both the number of degrees of freedom needed to accurately describe flexibility as the DAE-character of the system equations limit the computational efficiency. Bodylevel model reduction such modal synthesis is typically used to decrease the computational load of a simulation, but this cannot fully meet the demands for real-time simulation of flexible mechanisms. In this research, Global Modal Parametrization, a model reduction technique initially proposed for controller design for flexible mechanisms, is further developed to speed up simulation of multibody systems. The reduction is achieved by a system-level modal description, as opposed to the classic body-level modal description. As the dynamics is configuration-dependent, the systemlevel modal description is chosen configuration-dependent in such a way that the system dynamics is optimally described with a minimal number of degrees of freedom. Another novelty is GMP-based simulation. In a numerical experiment, simulation results for the original model equations are compared with simulation results for the model equations obtained after model reduction, showing a good match. The approximation errors resulting from the model reduction techniques are investigated by comparing results for different mode sets. The mode set affects the approximation error similarly as it does in linear modal synthesis. [less ▲] Detailed reference viewed: 45 (2 ULg) A system-level model reduction technique for efficient simulation of flexible multibody dynamics; Bruls, Olivier ; in Proceedings of the Multibody Dynamics ECCOMAS Conference (2009, June) In flexible multibody dynamics, body-level model reduction is typically used to decrease the computational load of a simulation. Body-level model reduction is generally performed by means of Component ... [more ▼] In flexible multibody dynamics, body-level model reduction is typically used to decrease the computational load of a simulation. Body-level model reduction is generally performed by means of Component Mode Synthesis. This offers an acceptable solution for many applications, but does not result in significant model reduction for systems with moving connection points, e.g. due to a flexible sliding joint. In this research, Global Modal Parametrization, a model reduction technique initially proposed for real-time control of flexible mechanisms, is further developed to speed up simulation of multibody systems. The reduction is achieved by a system-level modal description, as opposed to the classic body-level modal description. As the dynamics is configuration-dependent, the system-level modal description is chosen configuration-dependent in such a way that the system dynamics are optimally described with a minimal number of degrees of freedom. Moving connection points do not pose a problem to the proposed model reduction methodology. The complexity of simulation of the reduced model equations is estimated. The applicability to systems with moving connection points is highlighted. In a numerical experiment, simulation results for the original model equations are compared with simulation results for the model equations obtained after model reduction, showing a good match. The approximation errors resulting from the model reduction techniques are investigated by comparing results for different mode sets. The mode set affects the approximation error similarly as it does in linear modal synthesis. [less ▲] Detailed reference viewed: 57 (5 ULg) Systematic characterization of oil-in-water emulsion for formulation designRoland, Isabelle ; Piel, Géraldine ; Delattre, Luc et alConference (2003, May) Detailed reference viewed: 9 (1 ULg) Systematic characterization of oil-in-water emulsions for formulation designRoland, Isabelle ; Piel, Géraldine ; Delattre, Luc et alin International Journal of Pharmaceutics (2003), 263(1-2), 85-94 Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared. About 10 experiments were performed to characterize them. The goal of this research was to find Out ... [more ▼] Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared. About 10 experiments were performed to characterize them. The goal of this research was to find Out which tests should systematically be carried Out to assess efficiently the stability and the properties of ail emulsified preparation. Thus, formulation design requires at least the measurement of the droplet size, the determination of the zeta potential, a TurbiScan(R) analysis, the investigation of the stability under centrifugation and freeze/thaw cycles. If the emulsion contains an active substance, stability under storage at 4 degreesC and microscopic analysis are relevant. Quality Control Should be improved by measurements of viscosity and pH. (C) 2003 Elsevier B.V. All rights reserved. [less ▲] Detailed reference viewed: 44 (10 ULg) Systematic chromosomal aberrations found in murine bone marrow-derived mesenchymal stem cells.Josse, Claire ; ; Niessen, Neville-Andrew et alin Stem Cells & Development (2010), 19(8), 1167-1173 Mesenchymal stem cells (MSCs) are studied as a cellular source for the treatment of various diseases. In this work, we isolated and cultivated murine bone marrow-derived MSCs. After a first observation of ... [more ▼] Mesenchymal stem cells (MSCs) are studied as a cellular source for the treatment of various diseases. In this work, we isolated and cultivated murine bone marrow-derived MSCs. After a first observation of a solid tumour in a mouse injected with these cells, we systematically explored their chromosomal stability. We observed in all the cytogenetically analysed cases gross chromosomal alterations every time the MSCs went through the senescence crisis while the lymphocytes from the same animals showed a normal chromosome count. This observation was confirmed in different mouse strains, with different culture protocols, and even in short-term cultures after an hematopoietic cell negative immunodepletion performed in order to accelerate the isolation procedure. Therefore, we conclude that murine MSCs display high chromosomal instability, can generate tumours, and that care must be taken before using them for the evaluation of MSC therapeutic potential. [less ▲] Detailed reference viewed: 48 (15 ULg) Systematic color transformation effects in Stromgren photometryManfroid, Jean ; in Astronomy and Astrophysics (1992), 258 A major cause of errors in photometry is to be attributed to the color transformation. A thorough analysis of numerous observing runs carried out in the Stromgren system shows how reliable are the ... [more ▼] A major cause of errors in photometry is to be attributed to the color transformation. A thorough analysis of numerous observing runs carried out in the Stromgren system shows how reliable are the transformations in the different indices. Conclusions are drawn about the reduction methods, the validity of homogenization procedures, and the choice of the standard stars which define the system. [less ▲] Detailed reference viewed: 7 (0 ULg) Systematic Color Transformation Effects in Stromgren PhotometryManfroid, Jean ; in Precision Photometry: Astrophysics of the Galaxy (1991) Not Available Detailed reference viewed: 5 (0 ULg) |
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