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See detailNovel Higgs decay signals in R-parity violating models
Aristizabal Sierra, Diego ULg; Porod, W.; Restrepo, D. et al

in Physical Review. D : Particles and Fields (2008), 78

In supersymmetric models the lightest Higgs boson may decay with a sizable branching ratio into a pair of light neutralinos. We analyze such decays within the context of the minimal supersymmetric ... [more ▼]

In supersymmetric models the lightest Higgs boson may decay with a sizable branching ratio into a pair of light neutralinos. We analyze such decays within the context of the minimal supersymmetric standard model with R-parity violation, where the neutralino itself is unstable and decays into Standard Model fermions. We show that the R-parity violating couplings induce novel Higgs decay signals that might facilitate the discovery of the Higgs boson at colliders. At the LHC, the Higgs may be observed, for instance, through its decay -via two neutralinos- into final states containing missing energy and isolated charged leptons such as l±l∓,l±l±,3l, and 4l. Another promising possibility is the search for the displaced vertices associated with the neutralino decay. We also point out that Higgs searches at the LHC might additionally provide the first evidence of R-parity violation. [less ▲]

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See detailA novel high efficiency, low maintenance, hydroponic system for synchronous growth and flowering of Arabidopsis thaliana.
Tocquin, Pierre ULg; Corbesier, Laurent; Havelange, Andrée ULg et al

in BMC Plant Biology (2003), 3(2), 302003

Background: Arabidopsis thaliana is now the model organism for genetic and molecular plant studies, but growing conditions may still impair the significance and reproducibility of the experimental ... [more ▼]

Background: Arabidopsis thaliana is now the model organism for genetic and molecular plant studies, but growing conditions may still impair the significance and reproducibility of the experimental strategies developed. Besides the use of phytotronic cabinets, controlling plant nutrition may be critical and could be achieved in hydroponics. The availability of such a system would also greatly facilitate studies dealing with root development. However, because of its small size and rosette growth habit, Arabidopsis is hardly grown in standard hydroponic devices and the systems described in the last years are still difficult to transpose at a large scale. Our aim was to design and optimize an up-scalable device that would be adaptable to any experimental conditions. Results: An hydroponic system was designed for Arabidopsis, which is based on two units: a seed-holder and a 1-L tank with its cover. The original agar-containing seed-holder allows the plants to grow from sowing to seed set, without transplanting step and with minimal waste. The optimum nitrate supply was determined for vegetative growth, and the flowering response to photoperiod and vernalization was characterized to show the feasibility and reproducibility of experiments extending over the whole life cycle. How this equipment allowed to overcome experimental problems is illustrated by the analysis of developmental effects of nitrate reductase deficiency in nia1nia2 mutants. Conclusion: The hydroponic device described in this paper allows to drive small and large scale cultures of homogeneously growing Arabidopsis plants. Its major advantages are its flexibility, easy handling, fast maintenance and low cost. It should be suitable for many experimental purposes. [less ▲]

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See detailNovel high-resolution micro-CT based surface roughness measurement protocol for complex porous structures
Kerckhofs, Greet ULg; Pyka, Grzegorz; Moesen, Maarten et al

in Proceedings MetFoam 2011, Hur, B., Kim, S., Hyun, S. (Eds.) (2011)

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See detailNovel high-resolution micro-CT based surface roughness measurement protocol for complex porous structures
Kerckhofs, Greet ULg; Pyka, Grzegorz; Braem, Annabel et al

in Proceedings CellMat 2010 (2010)

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See detailA Novel Hypercomplex Solution to Kepler's Problem
Condurache, Daniel; Martinusi, Vladimir ULg

in Publications of the Astronomy Department of the Eotvos Lorand University (2007), 19

By using a Sundman like regularization, we offer a unified solution to Kepler's problem by using hypercomplex numbers. The fundamental role in this paper is played by the Laplace-Runge-Lenz prime integral ... [more ▼]

By using a Sundman like regularization, we offer a unified solution to Kepler's problem by using hypercomplex numbers. The fundamental role in this paper is played by the Laplace-Runge-Lenz prime integral and by the hypercomplex numbers algebra. The procedure unifies and generalizes the regularizations offered by Levi-Civita and Kustaanheimo-Stiefel. Closed form hypercomplex expressions for the law of motion and velocity are deduced, together with inedite hypercomplex prime integrals. [less ▲]

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See detailNovel ibandronate regimens in postmenopausal osteoporosis: design of the dosing intravenous administration (DIVA) study
Sambrook, P.; Reginster, Jean-Yves ULg; Recker, R. R. et al

in Osteoporosis International (2004, May), 15(Suppl.1), 118

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See detailA novel image-analysis toolbox enabling quantitative analysis of root system architecture
Lobet, Guillaume ULg; Pagès, L.; Draye, X.

in Plant Physiology (2011), 157(1), 29--39

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See detailA novel inactivating mutation of the LH/chorionic gonadotrophin receptor with impaired membrane trafficking leading to Leydig cell hypoplasia type 1.
Rivero-Muller, Adolfo; Potorac, Iulia ULg; Pintiaux, Axelle ULg et al

in European journal of endocrinology / European Federation of Endocrine Societies (2015), 172(6), 27-36

OBJECTIVE: The LH/chorionic gonadotrophin receptor (LHCGR) is a G protein-coupled receptor (GPCR) that plays a central role in male sexual differentiation, regulation of ovarian follicular maturation ... [more ▼]

OBJECTIVE: The LH/chorionic gonadotrophin receptor (LHCGR) is a G protein-coupled receptor (GPCR) that plays a central role in male sexual differentiation, regulation of ovarian follicular maturation, ovulation and maintenance of corpus luteum and pregnancy, as well as maintenance of testicular testosterone production. Mutations in the LHCGR gene are very rare. The aim of this work was to study the clinical and molecular characteristics of a rare familial LHCGR mutation. METHODS: Five affected members of a family, including a phenotypically female, but genotypically male (46,XY), patient with Leydig cell hypoplasia type 1 and four genotypically female siblings with reproductive abnormalities, were studied genetically. Cell trafficking studies as well as signalling studies of mutated receptor were performed. RESULTS: The five affected patients were all homozygous for a novel mutation in the LHCGR gene, a deletion of guanine in position 1850 (1850delG). This resulted in a frameshift affecting most of the C-terminal intracellular domain. In vitro studies demonstrated that the 1850delG receptor was completely incapable of transit to the cell membrane, becoming trapped within the endoplasmic reticulum. This could not be rescued by small-molecule agonist treatment or stimulated intracellularly by co-expression of a yoked human chorionic gonadotrophin. CONCLUSIONS: This novel LHCGR mutation leads to complete inactivation of the LHCGR receptor due to trafficking and signalling abnormalities, which improves our understanding of the impact of the affected structural domain on receptor trafficking and function. [less ▲]

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See detailNovel inhibitors of the sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives
Rogister, F.; Laeckmann, D.; Plasman, P.-O. et al

in European Journal of Medicinal Chemistry (2001), 36

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See detailNovel insights into the management of atypical myopathy in grazing horses based on recent series of European outbreaks and advances in etiological investigations
Votion, Dominique ULg; Gerber, Vinzent

in Proceedings of The 12th Congress of The World Equine Veterinary (2011, November 02)

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See detailNovel Instrumentation for the Measurement of the Unsteady Pressure Distribution around a Wing Undergoing Stall Flutter Oscillations
Li, Jing; Dimitriadis, Grigorios ULg; Gu, Fengshu et al

in Autumn Conference of the Institute of Acoustics 2007: Advances in Noise and Vibration Engineering (2007, October)

In this work, a wind tunnel model of a wing undergoing stall flutter oscillations is studied. It is a rectangular wing with pitch and plunge degrees of freedom and low pitch stiffness. The objective of ... [more ▼]

In this work, a wind tunnel model of a wing undergoing stall flutter oscillations is studied. It is a rectangular wing with pitch and plunge degrees of freedom and low pitch stiffness. The objective of this study is to promote the understanding of the stall flutter phenomenon by measuring the unsteady pressure distribution around the wing as well as the wing displacement, during unforced motion in two degrees of freedom. Both steady and unsteady pressures must be measured with sufficient accuracy during two types of tests. In the static tests the wing is to be clamped in position and not allowed to move and the steady pressures are to be measured around the centre-span section at different angles of attack. Thus the stall angle of attack can be identified and the stall mechanism characterized. In the dynamic tests the wing will be allowed to move and the unsteady pressures will be measured and recorded during a number of cycles of the oscillation, at a number of free stream airspeeds. [less ▲]

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See detailNovel large ring 1,3 bridged 2-azetidinones as potential inhibitors of penicillin-binding proteins
Urbach, Allan; Dive, Georges ULg; Marchand-Brynaert, Jacqueline

in European Journal of Organic Chemistry (2009), 11

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See detailA novel low cost spring-less RF MEMS Switch prototype
Kiang, K; Kraft, Michael ULg

in Proc. Eurosensors XXIV Conference (2010, September)

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See detailA novel lox/Cre-mediated multiple gene knockout procedue in the yeast Yarrowia lipolytica
Fickers, Patrick ULg; Le Dal, M.; Gaillardin, C. et al

Poster (2003, May 09)

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See detailNovel macromolecular architectures based on aliphatic polyesters: relevance of the "coordination-insertion" ring-opening polymerization
Mecerreyes, David; Jérôme, Robert ULg; Dubois, Philippe ULg

in Advances in Polymer Science (1999), 147

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e ... [more ▼]

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e., lactones, lactides, glycolide, is introduced. An insight into this so-called "coordination-insertion" mechanism and the ability of this living polymerization process to prepare well-defined homopolymers, telechelic polymers, random and block copolymers is then discussed. In the second part, the combination of the living ROP of (di)lac-tones with other well-controlled polymerization mechanisms such as anionic, cationic, free radical, and metathesis polyadditions of unsaturated comonomers, as well as polyconden-sations, is reported with special emphasis on the design of new and well-tailored macromolecular architectures. As a result of the above synthetic breakthrough, a variety of novel materials have been developed with versatile applications in very different fields such as biomedical and microelectronics. [less ▲]

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See detailNovel magneto-electric multiferroics from first-principles calculations
Varignon, Julien ULg; Bristowe, Nicholas ULg; Bousquet, Eric ULg et al

in Comptes Rendus Physique (2015), 16

Interest in first-principles calculations within the multiferroic community has been rapidly on the rise over the last decade. Initially considered as a powerful support to explain experimentally observed ... [more ▼]

Interest in first-principles calculations within the multiferroic community has been rapidly on the rise over the last decade. Initially considered as a powerful support to explain experimentally observed behaviours, the trend has evolved and, nowadays, density functional theory calculations have become also an essential predicting tool for identifying original rules to achieve multiferroism and design new magneto-electric compounds. This chapter aims at highlighting the key advances in the field of multiferroics, to which first-principles methods have contributed significantly. The essential theoretical developments that made this research possible are also briefly presented. [less ▲]

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See detailNovel markers reveal focal abnormalities of smooth muscles in human gastrointestinal motility disorders
Wedel, Theo; van Eys, G.; Waltregny, David ULg et al

Conference (2004)

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See detailA novel mathematical model to simulate and predict tissue regeneration
Geris, Liesbet ULg; Vander Sloten, Jos; Van Oosterwyck, Hans

in Middleton, J.; Jones, M. L.; Shrive, N. (Eds.) Proceedings of the 7th international symposium on Computer Methods in Biomechanics and Biomedical Engineering (2006)

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