Synthesis of new substituted lactones by "click" chemistry

in Arkivoc (2007), (x), 292-306

Several new oxepan-2-ones substituted by an ester, an ammonium, a hydroxyl, an acrylate and a poly(ethylene oxide) chain, respectively, were synthesized by the Huisgen's [3+2] cycloaddition of duly ... [more ▼]

Several new oxepan-2-ones substituted by an ester, an ammonium, a hydroxyl, an acrylate and a poly(ethylene oxide) chain, respectively, were synthesized by the Huisgen's [3+2] cycloaddition of duly substituted alkynes onto 5-azidooxepan-2-one. [less ▲]

Synthesis of new substituted poly(ε-caprolactone)s by comination of ring-opening polymerization, atom transfer radical addition and click reaction

Poster (2005, June 01)

Synthesis of New Tetraethyl(N-alkyl-1-aminoethan-1,1-diyl)bisphosphonates and ESR Analysis of Chemical Exchange of Derived Nitroxides of Acyclic Aminobisphosphonates.

in Phosphorus, Sulfur & Silicon & the Related Elements (2007), 182(10), 2359-2369

The synthesis and the full characterization of two new linear bisphosphonates(tetraethyl(N-tert-butyl-1-aminoethan-1,1-diyl)bisphosphonate and tetraethyl(Nsec-butyl-1-aminoethan-1,1-diyl)bisphosphonate ... [more ▼]

The synthesis and the full characterization of two new linear bisphosphonates(tetraethyl(N-tert-butyl-1-aminoethan-1,1-diyl)bisphosphonate and tetraethyl(Nsec-butyl-1-aminoethan-1,1-diyl)bisphosphonate), and the first analysis of the ESR spectra of the corresponding nitroxides is reported. The preliminary results of theoretical calculations on model compounds suggest a small B0 (in the McConnell equation). The results of bisphosphonate ester and bisphosphonic acid are similar. The discrepancies of P coupling for the diphosphorus compound stems from B2 that is different when the dihedral angle is larger than 90◦. [less ▲]

SYNTHESIS OF NONACTIVATED F-18 FLUORINATED AROMATIC-COMPOUNDS THROUGH NUCLEOPHILIC-SUBSTITUTION AND DECARBOXYLATION REACTIONS

in Applied Radiation & Isotopes (1992), 43(8), 1035-1040

The synthesis of no-carrier-added 3-[F-18]fluoroanisole, 2-[F-18]fluoroanisole, [F-18]fluorobenzene and 4-[F-18]fluoroveratrole are reported. The strategy consists of amino-polyether supported ... [more ▼]

The synthesis of no-carrier-added 3-[F-18]fluoroanisole, 2-[F-18]fluoroanisole, [F-18]fluorobenzene and 4-[F-18]fluoroveratrole are reported. The strategy consists of amino-polyether supported nucleophilic substitution with [F-18]F- on activated nitro aromatic aldehyde precursors followed by decarbonylation using Tris(triphenylphosphine) rhodium (I) chloride. The experimental parameters for this reaction have been studied and optimized with 2-[F-18]fluoro-4-methoxybenzaldehyde and then successfully applied to four other F-18-fluorinated aromatic aldehydes. The decarbonylation yields obtained were 84 +/- 5% (corrected for decay) within 15 min at 150-degrees-C in 1,4-dioxan. [less ▲]

Synthesis of novel amphiphilic and pH-sensitive ABC miktoarm star terpolymers

in Macromolecules (2006), 39(17), 5652-5656

Novel amphiphilic ABC miktoarm star terpolymers were synthesized that consist of hydrophilic poly( ethylene oxide) (PEO), hydrophobic poly(is an element of-caprolactone) (PCL), and pH-sensitive poly(2 ... [more ▼]

Novel amphiphilic ABC miktoarm star terpolymers were synthesized that consist of hydrophilic poly( ethylene oxide) (PEO), hydrophobic poly(is an element of-caprolactone) (PCL), and pH-sensitive poly(2-vinylpyridine) (P2VP), thus a water-soluble block upon protonation. In the first step, poly( ethylene oxide monomethyl ether) (MPEO) was capped by one omega-epoxy end group by reaction of the original hydroxy end group with epichlorohydrin. MPEO-b-P2VP diblock copolymers were prepared by nucleophilic addition of living P2VP-Li+ chains onto the epoxy group of MPEO's. Finally, the hydroxy group formed at the junction of the MPEO and P2VP blocks was used to initiate the ring-opening polymerization of is an element of-caprolactone in the presence of tin octoate. The ABC starshaped triblocks were characterized by H-1 NMR spectroscopy and size exclusion chromatography. [less ▲]

Synthesis of novel block copolymers by cobalt-mediated radical polymerization (CMRP) and isoprene-assisted radical coupling reaction (I-ARC)

Conference (2009, September 17)

Nowadays, progresses in medicine, biotechnology, microelectronic and many other fields are more and more sustained by the development of novel polymer materials with constantly improved properties and ... [more ▼]

Nowadays, progresses in medicine, biotechnology, microelectronic and many other fields are more and more sustained by the development of novel polymer materials with constantly improved properties and well-defined molecular parameters. In this context, we designed an innovative and very promising tool for macromolecular engineering. This technique, called Isoprene-Assisted Radical Coupling (I-ARC), allows to couple quantitatively polymer chains preformed by Cobalt-Mediated Radical Polymerization (CMRP), an efficient controlled radical polymerization system for vinyl acetate (VAc) and acrylonitrile (AN). Typically, addition of isoprene to well-defined polymers prepared by CMRP invariably leads to the quantitative coupling reaction of the chains, as assessed by the perfect doubling of the molar mass of the polymer. Importantly, the I-ARC reaction is not limited to macromolecules with low molar masses and homopolymers, contrary to the previously reported radical chains coupling methods. Indeed, when applied to diblock copolymers, I-ARC constitutes a straightforward approach for the synthesis of telechelic symmetrical ABA triblock copolymers, as illustrated by the preparation of poly(vinyl acetate)-b-poly(acrylonitrile)-b-poly(vinyl acetate) triblock copolymers and their derivatives. [less ▲]

Synthesis of novel conjugated oligomers for second-order nonlinear optics: incorporation of a central spacer as a conjugation modulator

in Journal of the Chemical Society. Perkin Transactions (1997), 2(6), 1209-1216

A new series of second-order nonlinear optical chromophores has been synthesized that consists of a conjugated segment end-capped with an electron acceptor and an electron donor, respectively, and a ... [more ▼]

A new series of second-order nonlinear optical chromophores has been synthesized that consists of a conjugated segment end-capped with an electron acceptor and an electron donor, respectively, and a central spacer intended to modulate the electro-optical effect. Conjugated chains have been tailored with trans-vinylene-1,5-thienylene as the building unit and N,N-dimethylamino and nitro groups as the donor–acceptor pair. Four spacers have been incorporated into the central part of the conjugated oligomers, which range from saturated to totally unsaturated functions, i.e. from methylene to vinylene units. The general strategy relies upon two consecutive Wittig or Wittig–Horner reactions between the spacer precursor and an aromatic phosphonium or phosphonate bearing the strong electron donor and the acceptor, respectively. Two synthetic pathways have been studied. The first procedure is based on the use of a symmetric precursor for the spacer. However, a reaction byproduct is formed, which must be removed and decreases the reaction efficiency. The second approach requires an asymmetric precursor for the spacer, the synthesis of which is a multistep process. In order to evaluate the effect of the spacer, a completely conjugated oligomer has been prepared by the one-step coupling of two conjugated segments end-functionalized by the electron donor and the acceptor, respectively. [less ▲]

Synthesis of novel functional aliphatic polyesters

in Polymer Preprints (2008), 49(1), 222-223

Synthesis of novel functional PEO as builiding block for biomaterials

Poster (2005, June 01)

Synthesis of novel polybutadiene-graft-poly(sodium methacrylate) amphiphilic copolymers as precursors for liquid crystalline graft copolymers

in Macromolecular Chemistry and Physics (1999), 200(7), 1630-2638

Well-defined polybutadiene-graft-poly(tert-butyl methacrylate) (PBD-g-PtBMA) copolymers were prepared by reaction of PtBMA chains end-capped with a tert-butyl 4-vinylbenzoate (tBVB) anion, with the ... [more ▼]

Well-defined polybutadiene-graft-poly(tert-butyl methacrylate) (PBD-g-PtBMA) copolymers were prepared by reaction of PtBMA chains end-capped with a tert-butyl 4-vinylbenzoate (tBVB) anion, with the selectively hydrosilylated 1,2-units of anionically synthesized PBD. Substitution of the tBVB anion for the anion of living PtBMA chains is required for the formation of the expected C-silylation product instead of the unstable O-silylation one. Subsequent hydrolysis of the poly(tert-butyl methacrylate) grafts followed by neutralization of the carboxylic acid groups by sodium hydroxide leads to amphiphilic polybuta-diene-graft-poly(sodium methacrylate) (PBD-g-PNaMA) graft copolymers. These copolymers form unimeric micelles in water, as observed by dynamic light scattering (DLS). Non-covalent liquid crystalline graft copo-lymers were prepared by cation exchange between PBD-g-PNaMA copolymers and an ammonium containing smectic mesogen. These copolymers form a smectic mesophase which is microphase separated from PBD. [less ▲]