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See detailA new and efficient one-pot synthesis of 2-hydroxy-1,4-dihydrobenzoxazines via a three-component Petasis reaction
Chouguiat, Louisa; Boulcina, Raouf; Carboni, Bertrand et al

in Tetrahedron Letters (2014), 55

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See detailNew and emerging issues in vocational education and training.
Armstrong, Russell; Béduwé, Catherine; Germe, Jean-François et al

in Descy, Pascaline; Tessaring, Manfred (Eds.) Modernising vocational education and training (2008)

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See detailA new and greener Common Agricultural Policy for 2015-2020 and its implementation in Wallonia
Burny, Philippe ULg

Conference (2014)

In order to implement the new Common Agricultural Policy agreed upon in 2013. the Walloon government had to make some choices, left to the Member States or the regions within them, which is the case in ... [more ▼]

In order to implement the new Common Agricultural Policy agreed upon in 2013. the Walloon government had to make some choices, left to the Member States or the regions within them, which is the case in Belgium. In July 2014, it was decided to implement the green payment (which is compulsory) proportionally to the basic payments), the payment for young farmers (compulsory) at a high level (1.8% of the total envelope for direct payments), an additional payment for the first 30 hectares (payment which is left to the choice of the Member State/region), coupled payments (as much as 21.3 % of the total amount of direct payments), and the basic payment (compulsory, representing 29.9 % of the total regional envelope for direct payments only in Wallonia). [less ▲]

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See detailA new and improved camera for the 1.5m B&C spectrograph
Jarvis, B.; Hutsemekers, Damien ULg

in The Messenger (1989), 56

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See detailNew and old contaminants in the River Meuse catchment
Geraerts; Belpaire; Focant, Jean-François ULg et al

Conference (2010, April)

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See detailNew and Paradoxical Roles of Matrix Metalloproteinases in the Tumor Microenvironment.
Noël, Agnès ULg; Gutierrez-Fernandez, A; Sounni, Nor Eddine ULg et al

in Frontiers in Pharmacology of Anti-Cancer Drugs (2012), 3(140), 1

Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly influenced by the surrounding microenvironment of the tumor. Therefore, the ability to change these surroundings ... [more ▼]

Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly influenced by the surrounding microenvironment of the tumor. Therefore, the ability to change these surroundings represents an important property through which tumor cells are able to acquire specific functions necessary for tumor growth and dissemination. Matrix metalloproteinases (MMPs) constitute key players in this process, allowing tumor cells to modify the extracellular matrix (ECM) and release cytokines, growth factors, and other cell-surface molecules, ultimately facilitating protease-dependent tumor progression. Remodeling of the ECM by collagenolytic enzymes such as MMP1, MMP8, MMP13, or the membrane-bound MT1-MMP as well as by other membrane-anchored proteases is required for invasion and recruitment of novel blood vessels. However, the multiple roles of the MMPs do not all fit into a simple pattern. Despite the pro-tumorigenic function of certain metalloproteinases, recent studies have shown that other members of these families, such as MMP8 or MMP11, have a protective role against tumor growth and metastasis in animal models. These studies have been further expanded by large-scale genomic analysis, revealing that the genes encoding metalloproteinases, such as MMP8, MMP27, ADAM7, and ADAM29, are recurrently mutated in specific tumors, while several ADAMTSs are epigenetically silenced in different cancers. The importance of these proteases in modifying the tumor microenvironment highlights the need for a deeper understanding of how stroma cells and the ECM can modulate tumor progression. [less ▲]

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See detailA new and potent activator of ATP-sensitive K+ channels
Antoine, M. H.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

Poster (1993, November 20)

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See detailA new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
Hargreaves, K.; Dubner, R.; Brown, F. et al

in Pain (1988), 32(1), 77-88

A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm uses an automated detection of the behavioral end-point; repeated testing does ... [more ▼]

A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm uses an automated detection of the behavioral end-point; repeated testing does not contribute to the development of the observed hyperalgesia. Carrageenan-induced inflammation resulted in significantly shorter paw withdrawal latencies as compared to saline-treated paws and these latency changes corresponded to a decreased thermal nociceptive threshold. Both the thermal method and the Randall-Selitto mechanical method detected dose-related hyperalgesia and its blockade by either morphine or indomethacin. However, the thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold. [less ▲]

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See detailNew and updated convex shape models of asteroids based on optical data from a large collaboration network
Hanuš, J.; Ďurech, J.; Oszkiewicz, D. A. et al

E-print/Working paper (2015)

Asteroid modeling efforts in the last decade resulted in a comprehensive dataset of almost 400 convex shape models and their rotation states. This amount already provided a deep insight into physical ... [more ▼]

Asteroid modeling efforts in the last decade resulted in a comprehensive dataset of almost 400 convex shape models and their rotation states. This amount already provided a deep insight into physical properties of main-belt asteroids or large collisional families. We aim to increase the number of asteroid shape models and rotation states. Such results are an important input for various further studies such as analysis of asteroid physical properties in different populations, including smaller collisional families, thermophysical modeling, and scaling shape models by disk-resolved images, or stellar occultation data. This provides, in combination with known masses, bulk density estimates, but constrains also theoretical collisional and evolutional models of the Solar System. We use all available disk-integrated optical data (i.e., classical dense-in-time photometry obtained from public databases and through a large collaboration network as well as sparse-in-time individual measurements from a few sky surveys) as an input for the convex inversion method, and derive 3D shape models of asteroids, together with their rotation periods and orientations of rotation axes. The key ingredient is the support of more that one hundred observers who submit their optical data to publicly available databases. We present updated shape models for 36 asteroids, for which mass estimates are currently available in the literature or their masses will be most likely determined from their gravitational influence on smaller bodies, which orbital deflection will be observed by the ESA Gaia astrometric mission. This was achieved by using additional optical data from recent apparitions for the shape optimization. Moreover, we also present new shape model determinations for 250 asteroids, including 13 Hungarias and 3 near-Earth asteroids. [less ▲]

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See detailNew and Updated Modules to Performed Stress and Strength Analysis
Zanic, V.; Jancijev, T.; Andric, J. et al

in IMPROVE Workshop (EU Project FP6 n°031382), DUBROVNIK 17-18 Sept. 2009, Croatia (2009, September)

Report about IMPROVE FP6 EU project

Detailed reference viewed: 43 (2 ULg)
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See detailNew answers on the interaction between polymers and vortices in turbulent flows
Dubief, Yves; Terrapon, Vincent ULg; White, Christopher M et al

in Flow, Turbulence and Combustion (2005), 74(4), 311-329

Numerical data of polymer drag reduced flows is interpreted in terms of modification of near-wall coherent structures. The originality of the method is based oil numerical experiments in which boundary ... [more ▼]

Numerical data of polymer drag reduced flows is interpreted in terms of modification of near-wall coherent structures. The originality of the method is based oil numerical experiments in which boundary conditions or the governing equations are modified in a controlled manner to isolate certain features of the interaction between polymers and turbulence. As it result, polymers are shown to reduce drag by damping near-wall vortices and sustain turbulence by injecting energy onto the streamwise velocity component in the very near-wall region. [less ▲]

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See detailNew anti-herpetic strategies
Rentier, Bernard ULg

Conference (1995, October 10)

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See detailNew antibacterial cationic surfactants prepared by Atom Transfer Radical Polymerization
Lenoir, Sandrine ULg; Pagnoulle, Christophe; Detrembleur, Christophe ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2006), 44(3), 1214-1224

Efficient antibacterial surfactants have been prepared by the quaternization of the amino groups of poly(ethylene-co-butylene)-b-poly[2-(dimethylamino)ethylmethacrylate] (PEB-b-PDMAEMA) diblock copolymers ... [more ▼]

Efficient antibacterial surfactants have been prepared by the quaternization of the amino groups of poly(ethylene-co-butylene)-b-poly[2-(dimethylamino)ethylmethacrylate] (PEB-b-PDMAEMA) diblock copolymers by octyl bromide. The diblock copolymers have been synthesized by ATRP of 2-(dimethylamino)ethylmethacrylate (DMAEMA) initiated by an activated bromide-end-capped poly(ethylene-co-butylene). In the presence of CuBr, 1,4,7,10,10-hexamethyl-triethylenetetramine (HMTETA), and toluene at 50 °C, the initiation is slow in comparison with propagation. This situation has been improved by the substitution of CuCl for CuBr, all the other conditions being the same. Finally, the addition of an excess of CuCl2 (deactivator) to the CuCl/HMTETA catalyst is very beneficial in making the agreement between the theoretical and experimental number-average molecular weights excellent. The antibacterial activity of PEB-b-PDMAEMA quaternized by octyl bromide has been assessed against bacteria and is comparable to the activity of a commonly used disinfectant, that is, benzalkonium chloride. [less ▲]

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See detailNew anticomplement polypeptide from salivary glands of the tick Ixodes Ricinus
Daix, V.; Godfroid, E.; Pastoret, Paul-Pierre ULg et al

Patent (2003)

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See detailNew Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots
Frederich, Michel ULg; De Pauw-Gillet, Marie-Claire ULg; Llabres, Gabriel ULg et al

in Planta Medica (2000), 66(3), 262-9

Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy ... [more ▼]

Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38). [less ▲]

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See detailNew antiobesity agents in type 2 diabetes: overview of clinical trials with sibutramine and orlistat.
Scheen, André ULg; Ernest, Philippe ULg

in Diabètes & Métabolism (2002), 28(6 Pt 1), 437-45

Besides genetic predisposition, obesity is the most important risk factor for the development of type 2 diabetes mellitus. Even modest weight reduction can improve blood glucose control in overweight ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of type 2 diabetes mellitus. Even modest weight reduction can improve blood glucose control in overweight subjects. After failure of lifestyle modifications, antiobesity drugs such as orlistat, a potent and selective inhibitor of gastric and pancreatic lipases that reduces lipid intestinal absorption, or sibutramine, a noradrenaline and 5-hydroxytryptamine reuptake inhibitor that regulates food intake, may be considered to favour weight loss and/or weight maintenance. Several placebo-controlled studies have recently demonstrated that both drugs are able to promote weight loss in obese type 2 diabetic patients treated with diet alone, sulphonylureas, metformin or insulin. The greater weight reduction as compared to placebo was associated with a significant reduction of glycated haemoglobin levels and/or of the doses of classical antihyperglycaemic agents, especially in good responders who lost at least 10% of initial body weight. In addition, vascular risk factors associated to insulin resistance were also reduced after weight loss. These antiobesity agents may also contribute to delay or prevent the progression from impaired glucose tolerance to overt type 2 diabetes in at risk obese individuals ("Xenical in the prevention of diabetes in obese subjects" trial). Large long-term prospective studies, such as the "Sibutramine cardiovascular and diabetes outcome study" should better determine the place of pharmacological anti-obesity strategy in the overall management of obese patients with impaired glucose tolerance or type 2 diabetes. [less ▲]

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See detailNew appendix criteria open for a broader concept of chronic migraine.
Olesen, J.; Bousser, M*-G; Diener, H*-C et al

in Cephalalgia : An International Journal of Headache (2006), 26(6), 742-6

After the introduction of chronic migraine and medication overuse headache as diagnostic entities in The International Classification of Headache Disorders, Second Edition, ICHD-2, it has been shown that ... [more ▼]

After the introduction of chronic migraine and medication overuse headache as diagnostic entities in The International Classification of Headache Disorders, Second Edition, ICHD-2, it has been shown that very few patients fit into the diagnostic criteria for chronic migraine (CM). The system of being able to use CM and the medication overuse headache (MOH) diagnosis only after discontinuation of overuse has proven highly unpractical and new data have suggested a much more liberal use of these diagnoses. The International Headache Classification Committee has, therefore, worked out the more inclusive criteria for CM and MOH presented in this paper. These criteria are included in the appendix of ICHD-2 and are meant primarily for further scientific evaluation but may be used already now for inclusion into drug trials, etc. It is now recommended that the MOH diagnosis should no longer request improvement after discontinuation of medication overuse but should be given to patients if they have a primary headache plus ongoing medication overuse. The latter is defined as previously, i.e. 10 days or more of intake of triptans, ergot alkaloids mixed analgesics or opioids and 15 days or more of analgesics/NSAIDs or the combined use of more than one substance. If these new criteria for CM and MOH prove useful in future testing, the plan is to include them in a future revised version of ICHD-2. [less ▲]

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See detailNew applications of Advanced Manufacturing Methods for space instrumentation and Systems of Nanospacecraft
Rochus, Pierre ULg; Plesseria, Jean-Yves ULg; Corbelli, Alberto et al

Conference (2014, October 03)

In the frame of an ESA TRP project, our consortium has investigated the possibility to use advanced manufacturing methods for application to space hardware. After a review of the state of the art of the ... [more ▼]

In the frame of an ESA TRP project, our consortium has investigated the possibility to use advanced manufacturing methods for application to space hardware. After a review of the state of the art of the new manufacturing methods, including additive manufacturing but also advanced bonding, joining and shaping techniques, several case studies have been realized. These new techniques imply a different approach already at the design phase since the manufacturing constraints can be completely different. The goal of the project was to evaluate the different technologies from the design to the realization and learn how the classical design and development of such parts shall be adapted to take into account the different specificities of the new techniques. Three types of case studies have been developed successively. The first type was a re-manufacture of an existing piece of hardware using advanced techniques to evaluate if there is some potential improvement to be achieved (cost, production time, complexity reduction). The second level was to design and manufacture a part based on the application requirements. The last level was to design and manufacture a part taking into account in addition the subsystem to which it belongs. All case studies have been tested in terms of achieved performances and resistance to the mechanical and thermal environment. For each level, several case studies were proposed by ALMASpace and TAS-F and a pre-selection was performed to verify the feasibility and the interest of the proposed part for the project. For the first 2 levels, the 2 selected case studies have been designed, built and tested. A single case study was built for last level. The cases studies of level one were an aluminium inertial wheel housing (using electron beam welding to connect simple machined parts) and a mechanism housing fully made by additive manufacturing (electron beam melting of Titanium). The ones of level two were an aluminium tray for nanosatellite structure (assembled by salt dip brazing) and an antenna support bracket (designed by topological optimization and manufactured by laser beam melting of aluminium). The third level case study is a Sun Sensor for nanosatellite designed by topological optimization and including electronic circuit (optical detector and proximity electronic) deposited by aerosol jet printing directly on the aluminium structure. All case studies have been manufactured and tested and all part manufactured, despite including some imperfections, fulfilled all performance requirements. [less ▲]

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See detailNew applications of rapid prototyping and rapid manufacturing (RP/RM) technologies for space instrumentation
Rochus, Pierre ULg; Plesseria, Jean-Yves ULg; van Elsen, M. et al

in Acta Astronautica (2007), 61

In the frame of a research project, CRIF, KUL and CSL have investigated the possibility to use rapid prototyping and rapid manufacturing (RP/RM) techniques during space instrument development. Rapid ... [more ▼]

In the frame of a research project, CRIF, KUL and CSL have investigated the possibility to use rapid prototyping and rapid manufacturing (RP/RM) techniques during space instrument development. Rapid prototyping and rapid manufacturing terms gather several techniques with the common baseline that parts are built layer by layer, starting from a CAD model. These techniques imply powder, paste or liquid and are applicable to polymers, ceramics and metals. In a first step, the major advantages of these techniques have been presented to Belgian industries implied in the space sector and, as a result of the discussions, development goals for the project have been identified. Several types of use have also been pointed, from demonstration mock-up to real space hardware. In parallel to technical developments, several case studies and tests have been performed. The case studies have shown that the rapid manufacturing allows complex geometries to be created. A drastic decrease of the number of separate parts and bolted junctions ease the predictability of the mechanical and thermal behaviour and limit the risk of imperfect junction. As a result of the project, a guidelines document has been issued to give as much information as possible on how to perform a space instrument design using the advantages of RP/RM techniques. [less ▲]

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