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See detailPrix Nobel de Chimie 2008: Suivre les protéines à la trace grâce à la GFP («Green Fluorescent Protein»)
Houssier, Claude ULg; Muller, Marc ULg

in Science et Culture (2008), 416

La GFP permet de voir les protéines directement dans les organismes vivants, de les localiser grâce à la fluorescence qu’elle émet. Par manipulation génétique, on peut accrocher la GFP à diverses ... [more ▼]

La GFP permet de voir les protéines directement dans les organismes vivants, de les localiser grâce à la fluorescence qu’elle émet. Par manipulation génétique, on peut accrocher la GFP à diverses protéines que l’on peut ainsi suivre à la trace dans les cellules en fonctionnement. Comme une large variété de mutants de la GFP émettant des fluorescences de couleurs différentes sont disponibles, on peut même localiser plusieurs protéines simultanément. Quel merveilleux outil pour l’imagerie en microscopie optique ! [less ▲]

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See detailLes prix prédateurs entre la lettre de la jurisprudence et l’esprit du raisonnement économique (note sous TPICE, 30 janvier 2007, France Telecom/Commission, T-340/03)
Sibony, Anne-Lise ULg

in Petites Affiches, la Loi (2007)

It is argued that the Wanadoo judgement of the CFI is a missed opportunity to develop the AKZO and Tetra Pak case law into a legal test which would be more amenable to economic thinking about predation.

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See detailPrix prédateurs : La Cour d’appel de Paris saisit l’Autorité de la Concurrence d’une demande d’avis pour apprécier le caractère prédateur d’un prix nul
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2014), 1

CA Paris, 20 novembre 2013, Google France et Google c/ Bottin Cartographe

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See detailPRIX WALLON DE LA QUALITE 2009 : « La Qualité : ombre et lumière »
LEROY, Dominique; DELGAUDINE, Marie ULg

Article for general public (2009)

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See detailPRL tumors : diagnosis and treatment
Beckers, Albert ULg

Scientific conference (2013, November 18)

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See detail"Pro Patria". La réponse belge face au martyre de son patrimoine durant la Première Guerre mondiale
Rusch, Arnaud ULg

in Costa, Sandra; Pizzo, Marco (Eds.) Le muse ferite (1914-1918): fotografia storica e percezione del patrimonio (2014)

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See detailPro- and antigelatinolytic activities in the serum and airways of cats with experimentally-induced asthma
Leemans, Jérôme ULg; Kirschvink; Clercx, Cécile ULg et al

in Proceedings : 25th Symposium of the Veterinary Comparative Respiratory Society (2007)

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See detailThe pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
Devy, L.; Blacher, Silvia ULg; Grignet-Debrus, Christine ULg et al

in FASEB Journal (2002), 16(2), 147-54

Plasminogen activator inhibitor 1 (PAI-1) is believed to control proteolytic activity and cell migration during angiogenesis. We previously demonstrated in vivo that this inhibitor is necessary for ... [more ▼]

Plasminogen activator inhibitor 1 (PAI-1) is believed to control proteolytic activity and cell migration during angiogenesis. We previously demonstrated in vivo that this inhibitor is necessary for optimal tumor invasion and vascularization. We also showed that PAI-1 angiogenic activity is associated with its control of plasminogen activation but not with the regulation of cell-matrix interaction. To dissect the role of the various components of the plasminogen activation system during angiogenesis, we have adapted the aortic ring assay to use vessels from gene-inactivated mice. The single deficiency of tPA, uPA, or uPAR, as well as combined deficiencies of uPA and tPA, did not dramatically affect microvessel formation. Deficiency of plasminogen delayed microvessel outgrowth. Lack of PAI-1 completely abolished angiogenesis, demonstrating its importance in the control of plasmin-mediated proteolysis. Microvessel outgrowth from PAI-1(-/-) aortic rings could be restored by adding exogenous PAI-1 (wild-type serum or purified recombinant PAI-1). Addition of recombinant PAI-1 led to a bell-shaped angiogenic response clearly showing that PAI-1 is proangiogenic at physiological concentrations and antiangiogenic at higher levels. Using specific PAI-1 mutants, we could demonstrate that PAI-1 promotes angiogenesis at physiological (nanomolar) concentrations through its antiproteolytic activity rather than by interacting with vitronectin. [less ▲]

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See detailPro-inflammatory cytokines and pulmonary function
Lekeux, Pierre ULg; Linden, Annick ULg

in Pulmonary Function in Healthy, Exercising and Diseased Animals (1993)

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See detailPro-inflammatory cytokines and pulmonary function
Lekeux, Pierre ULg

in Lekeux, Pierre (Ed.) Pulmonary Function in Healthy, Exercising and Diseased Animals (1993)

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See detailPro-inflammatory properties for thiazolidinediones.
Desmet, Christophe ULg; Warzée, Barbara ULg; Gosset, Philippe et al

in Biochemical Pharmacology (2005), 69(2), 255-265

Thiazolidinediones (TZDs) are pharmacological ligands of the peroxisome proliferator-activated receptor (PPAR)-gamma that are extensively used in the treatment of type II diabetes. Recently, an anti ... [more ▼]

Thiazolidinediones (TZDs) are pharmacological ligands of the peroxisome proliferator-activated receptor (PPAR)-gamma that are extensively used in the treatment of type II diabetes. Recently, an anti-inflammatory potential for TZDs has been suggested, based on observations that these compounds may inhibit pro-inflammatory cytokine expression in vitro and may attenuate the inflammatory response in vivo. Here, we show that the TZDs rosiglitazone (RSG) and troglitazone (TRO) do not inhibit the inflammatory response to tumor necrosis factor (TNF)-alpha in various epithelial cell types. On the contrary, both RSG and TRO significantly potentiated TNF-alpha-induced production of granulocyte/macrophage-colony-stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells. This increase in pro-inflammatory cytokine expression was functionally significant as supernatants from cells co-treated with TNF-alpha and TZDs displayed increased neutrophil pro-survival activity when compared with supernatants from cells treated with TNF-alpha alone. Additionally, it was shown that TZDs enhance cytokine expression at the transcriptional level, but that the pro-inflammatory effects of TZDs are independent on PPARgamma, nuclear factor kappaB or mitogen-activated protein kinase activation. Our study shows that TZDs may potentiate the inflammatory response in epithelial cells, a previously unappreciated effect of these compounds [less ▲]

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See detailA pro-inflammatory role for the cyclopentenone prostaglandins at low concentrations: oxidative stress-induced ERK activation without NFKB inhibition
Bureau, Fabrice ULg; Desmet, Christophe ULg; Melotte, D. et al

in Proceedings : Congress "Cell signaling, transcription and translation as therapeutics targets" (2002)

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See detailPro-social behaviour in childhood : a psychosocial experimental approach
Born, Michel ULg; Stark, M. H.

Report (1989)

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See detailPro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency
Pernasetti, Flavia; Milner, Robert DG; al Ashwal, Abdullah A Z et al

in Journal of Clinical Endocrinology and Metabolism (1998), 83(6), 2079-83

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven ... [more ▼]

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven children with GH, PRL, and TSH deficiency from three, reportedly unrelated, Middle Eastern families, harboring a newly recognized Pro- > Ser recessive mutation in codon 239 of the Pit-1 gene. The mutated residue is located at the beginning of the second alpha-helix of the POU-homeodomain and is strictly conserved among all POU proteins. The Pro239Ser mutant binds DNA normally but is unable to stimulate transcription. [less ▲]

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See detailProanthocyanidins from Ribes nigrum 1 Isolation and structure determination
Tits, Monique ULg; Angenot, Luc ULg; Warin, Roger et al

Poster (1992, May)

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See detailProanthocyanidins from Ribes nigrum 2. TLC Analysis
Tits, Monique ULg; Poukens, Pascale; Angenot, Luc ULg

Poster (1990, July)

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See detailProanthocyanidins from Ribes nigrum leaves
Tits, Monique ULg; Poukens, Pascale; Angenot, Luc ULg

Poster (1992, May)

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See detailProanthocyanidins from Ribes nigrum leaves - Isolation and structure determination
Tits, Monique ULg; Angenot, Luc ULg; Warin, Roger et al

in Bulletin de Liaison Groupe Polyphenols (1992)

In summary, the antiinflammatory activity of Ribes nigrum leaves is mainly due to proanthocyanidins which are the major oligomers in the proanthocyanidins fraction

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See detailProanthocyanidins from Ribes nigrum leaves 1. Isolation and structure determination
Tits, Monique ULg; Angenot, Luc ULg; Warin, Roger et al

Poster (1990, July)

Detailed reference viewed: 13 (1 ULg)