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Peer Reviewed
See detailMélanges Pierre Colman
Duchesne, Jean-Patrick ULg

in Art&fact (1996), 15

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See detailMelanin-concentrating hormone and immune function
Lakaye, Bernard ULg; Coumans, Bernard ULg; Harray, Sophie ULg et al

in Peptides (2009), 30

To date,melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence ... [more ▼]

To date,melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence, demonstrating that MCH and its receptors are expressed by cells of the immune system and directly influence the response of these cells in some circumstances. This therefore supports the idea that, as with other peptides, MCH could be considered as a modulator of the immune system. Moreover, we suggest that this could have important implications in several immune-mediated disorders and affirm that there is a clear need for further investigation [less ▲]

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See detailMelanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume
Conductier, G; Brau, F; Viola, A et al

in Nature Neuroscience (2013), 16

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See detailMélanodermie infraclinique et cancers photo-induits
QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg; HENRY, Frédérique ULg et al

in Actualités en Ingéniérie Cutanée (2006)

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See detailLa melanogenese, expression de la differenciation de cellules cancereuses en culture
Bassleer, Roger; De Pauw-Gillet, Marie-Claire ULg; Giet, Didier ULg et al

in Bulletin de l'Association des Anatomistes (1982), 66(194), 291-295

In B16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analyzed by cytological and cytochemical methods. When cultured for long periods (several months ... [more ▼]

In B16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analyzed by cytological and cytochemical methods. When cultured for long periods (several months), melanogenesis is expressed according to a cyclic way, even when maintained in a culture medium of constant composition and without adding any chemical agent eventually able to influence this phenomenon. The spontaneous cyclic activity is analyseed and an explanation is given as an hypothesis. [less ▲]

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See detailMelanoma AntiGEn D2 (MAGED2) a new partner of the DNA damage response?
Pirlot, Céline ULg; Piette, Jacques ULg; Habraken, Yvette ULg

Poster (2014, January)

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. It is ubiquitously expressed and its overexpression in many cancers could make it a potential biomarker of tumor development and ... [more ▼]

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. It is ubiquitously expressed and its overexpression in many cancers could make it a potential biomarker of tumor development and metastasis formation. Actually, the only known function of this protein is its involvement in the p53 pathways. Indeed, MAGED2 could be a negative regulator of p53 and it increases apoptosis induced by TRAIL in a p53 dependent manner. Moreover, a phosphoproteomic experiment has shown that this protein is likely phosphorylated by ATM, ATR or DNA-PK after exposition to ionizing irradiation. These three kinases are implicated in the DNA damage response (DDR). Our lab showed by yeast two hybrids an interaction between MAGED2 and ATM. Thus, the aims of the project are to confirm and to find the function of this interaction in a DDR context. Current avenues of investigations include determining the impact of MAGED2 depletion and overexpression in the p53, NF-kappaB and cell cycle regulation following double strand break induced by etoposide treatment. Though this study we plan to confirm a new partner of ATM in the DDR pathway, which could be targeted to limit cancer progression and improve the chemotherapy relying on DNA damaging compounds. [less ▲]

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See detailMelanoma AntiGEn D2 (MAGED2): a new nucleolar protein undergoing re-localization after cellular stress
Pirlot, Céline; Thiry, Marc ULg; Trussart, Charlotte ULg et al

Poster (2015, February 06)

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, the only known function of this protein is its involvement in the p53 pathway. Indeed, MAGED2 could be a negative regulator of ... [more ▼]

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, the only known function of this protein is its involvement in the p53 pathway. Indeed, MAGED2 could be a negative regulator of p53. It contributes to the initiation of melanoma when its overexpression is associated with the mutation of BRAF and it increases apoptosis induced by TRAIL in a p53 dependent manner. Moreover, phosphoproteomic experiments have shown that this protein is likely phosphorylated by kinases implicated in the DNA damage response (DDR). We decided to investigate the intra-cellular localization of MAGED2 in order to find new functions of this protein. In resting cell, MAGE D2 is detected is the nucleus, the nucleolus and the cytoplasm. We observed that MAGED2 localization change during cell cycle and genotoxic stress. Nuclear and nucleolar localization signals were identified. Though present in the nucleolus, the depletion of MAGED2 does not affect the structure of this organel. [less ▲]

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See detailMelanoma AntiGEn D2 : a new nucleolar protein undergoing delocalization during cell cycle and after cellular stress
Pirlot, Céline; Thiry, Marc ULg; Trussart, Charlotte ULg et al

Poster (2015, September 28)

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, little is known on MAGED2 function. It contributes to the initiation of melanoma when its overexpression is associated with the ... [more ▼]

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, little is known on MAGED2 function. It contributes to the initiation of melanoma when its overexpression is associated with the mutation of BRAF and it increases apoptosis induced by TRAIL in a p53-dependent manner. MAGED2 was also shown to be a negative regulator of p53, bur we did not confirm this properties. Moreover, proteomic analyses detected numerous phosphorylated or acetylated residues in response to stess and within cell cycle suggesting its involvement in cellular signal transduction. We investigated the intra-cellular re-localization of MAGED2 during cell cycle and after genotixc stress. Both nucleolar and nuclear signals were identifed. [less ▲]

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See detailMelanoma antigen D2, a substrate of ATM, is a nucleolar protein that shuttles with cell cycle and cellular stress.
Pirlot, Céline; Thiry, Marc ULg; Trussart, Charlotte ULg et al

Poster (2015, November 03)

ATM coordinates numerous facets of the highly regulated DDR network. In order to identify new ATM substrates we have performed a yeast two hybrid experiment with HEAT domains of ATM and an HeLa cDNA ... [more ▼]

ATM coordinates numerous facets of the highly regulated DDR network. In order to identify new ATM substrates we have performed a yeast two hybrid experiment with HEAT domains of ATM and an HeLa cDNA library. Melanoma antigen D2 (MAGED2) was one of the interacting proteins identified in this screen. MAGED2 belongs to the type II Melanoma AntiGEn (MAGE) family. MAGE homology domain, shared by all MAGE proteins, was shown to enhance E3 ligase activity. Actually, little is known about MAGED2 functions. Like every type II MAGE protein, it is expressed in all adult tissues. However, MAGE-D2 has the particularity to be over-expressed in numerous primary cancer and metastasis and it is now recognized as a tumour marker. This over-expression suggests that MAGED2 could be important for the process of cancerisation. MAGED2 was also shown to be a negative regulator of p53, but we did not confirm this property. Proteomic analyses also detected numerous phosphorylated or acetylated residues in response to stress and during cell cycle progression, suggesting a role in cellular signal transduction. We identified the residues targeted by ATM in MAGE-D2 and analysed the localisation of MAGED2 during the interphase and after genotoxic/nucleolar stresses. [less ▲]

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See detailMelanoma antigen-D2: a nucleolar protein undergoing delocalization during cell cycle and after cellular stress
Pirlot, Céline ULg; Thiry, Marc ULg; Trussart, Charlotte ULg et al

in BBA Molecular Cell Research (2016), 1853(3), 581-595

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See detailMelanoma masquerading as nomelanocytic lesions
DETRIXHE, Audrey ULg; Libon, Florence ULg; MANSUY, Marion ULg et al

in Melanoma Research (2016)

Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented ... [more ▼]

Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented melanoma and even of amelanotic melanoma. However, the dermatologist's nightmare is the small group of melanomas that present as common skin diseases, often associated with a significant delay in diagnosis and hence a poor prognosis. The study was carried out to prospectively assess the number of melanomas lacking any clinical suspicion of melanoma and to describe their clinical and histological features over a 6-year observation period in an University Tertiary Skin Cancer Center. Out of 502 cases of newly diagnosed cases of melanoma, seven (1.4%) nonpigmented and nonamelanotic cases of melanoma were identified. The mean age of the patients was 69 years (two females/five males). All cases were discovered by chance on a punch biopsy. The clinical diagnostic suspicions were basal cell carcinoma, fungal intertrigo, keratoacanthoma, lichenoid keratoma, diabetic foot ulcer, eczema, and necrotic pressure ulcer. Dermoscopy, performed after the punch biopsies, was only partially contributive. The mean histological thickness was 2.7 mm, the mean number of mitoses was 7/mm, local micrometastases were present in 5/7 (71%), the mean Ki67 count was 18.9%, and a positive sentinel lymph node was observed in 4/6 (66%) cases. Nonpigmented and nonamelanotic melanomas are rare, are at high risk, and have a poor prognosis because of a delayed diagnosis. Dermoscopy is only of partial diagnostic aid. Treatment resistance or atypical behavior of the above-mentioned lesions should lead to biopsy. [less ▲]

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See detailMelanoma screening: results of the first one-day campaign in Belgium (‘Melanoma Monday’)
Vandaele, M.; Richert, Bertrand ULg; Van der Endt, J. M. et al

in Journal of the European Academy of Dermatology & Venereology (2000), 14

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a ... [more ▼]

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a media campaign, with more relevant information and the opportunity for free skin inspections. Methods: A ‘Task Force’ organized a media campaign in April 1999 and convinced 65% of the Belgian dermatologists to give up 4 h of their time to do free skin examinations for skin cancer on Monday 26 April 1999; it was called ‘Melanoma Monday’. Results: A total 2767 patients were screened. We found 25 melanomas and suspected 59 basal cell carcinomas. In the following 4 weeks another 141 melanomas were found. These 166 melanomas found in one month represent 15 –20% of the total number of melanomas per year in Belgium. Summary: A media campaign with relevant information combined with screening opportunities can lead to the early detection of melanomas in a large number of patients and can continue to alert people at risk in the following weeks. [less ▲]

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Peer Reviewed
See detailLe mélanome B16 de la souris en culture à trois dimensions
De Pauw-Gillet, Marie-Claire ULg; Christiane, Y.; Foidart, Jean-Michel ULg et al

in Bulletin de l'Association des Anatomistes (1986), 70(210), 21-4

Multicellular spheroids composed of mouse B16 melanoma cells have been prepared in non agitated culture on solid agar. Cells present frequent contacts and an extracellular matrix appears during ... [more ▼]

Multicellular spheroids composed of mouse B16 melanoma cells have been prepared in non agitated culture on solid agar. Cells present frequent contacts and an extracellular matrix appears during cultivation (up to 2 months in agitated suspension); it contains laminin, fibronectin and collagen I, III and IV. Cellular differentiation takes place inside these spheroids (melanogenesis progressively increases), but a relatively intense cell proliferation rate is also maintained. [less ▲]

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See detailLe mélanome cutané dans une perspective liégeoise. Actualisation de son épidémiologie et avancées diagnostiques.
Quatresooz, Pascale ULg; Hustinx, Roland ULg; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2007), 62(Supplément), 52-55

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented ... [more ▼]

Cutaneous melanoma is one of the research poles at the University Hospital of Liège. Since 20 years or so, the dermatopathology laboratory with the contribution of the Mosan Study Group of Pigmented Neoplasms have scrutenised the epidemiological evolution of this cancer. We have disclosed a sharp increase in the global incidence of melanoma, more particularly in women in the age of procreation. We have also contributed and innovated in terms of clinical diagnosis by introducing dermoscopy and initiating both the ULEV method and the cyanoacrylate skin surface stripping. In the field of dermatopathology we have developed an immunohistological panel allowing to fine tune the diagnosis and to define some histoprognostic criteria. For the checkup of the disease extension, the PET scan method has been particularly refined. [less ▲]

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See detailLe mélanome cutané sporadique au-delà de sa classification normative. Plaidoyer prenant en compte son particularisme évolutif
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg

in Revue Médicale de Liège (2015), 70(5-6), 277-281

For aeons, cutaneous sporadic melanoma, exhibiting either a slow or rapid growth rate, is identified using a set of well defined histopathological criteria. Such diagnostic step is greatly appreciated ... [more ▼]

For aeons, cutaneous sporadic melanoma, exhibiting either a slow or rapid growth rate, is identified using a set of well defined histopathological criteria. Such diagnostic step is greatly appreciated, and it brings a rough estimate of the probable evolution of the cancer. Some additional assessments try to improve the progressive prognosis of cutaneous melanoma. In this scope, fractals and spectral analyses expect to better perceive the individual progressive characteristics of each tumor. The extent in the tumoral germinative compartment and the peritumoral microvascular network are explored and should in a near future make clear the progressive potential of cutaneous melanoma. The possible tumoral regression and the immune reaction should be better perceived. [less ▲]

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See detailLe melanome cutane: innovations conceptuelles et therapeutiques, fruit de la recherche translationnelle.
Pierard, Gérald ULg; Quatresooz, Pascale ULg; Rorive, Andrée ULg et al

in Revue Médicale de Liège (2008), 63(10), 579-84

The scientific information about melanoma is on the rise. It has a direct impact on the diagnostic acuteness and on the therapeutic management. The most recent aspects of the utmost importance are ... [more ▼]

The scientific information about melanoma is on the rise. It has a direct impact on the diagnostic acuteness and on the therapeutic management. The most recent aspects of the utmost importance are presented. The concept of the duality between fast-growing (high malignancy) and slow-growing (reduced malignancy) melanoma is stressed. A new international multicentric approach using adjuvant therapy for stage III melanomas involves the clinical oncology department of the CHU of Liege. It concerns a targeted immunotherapy directed to the Mage A3 protein. [less ▲]

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See detailLe melanome cutane: une seule maladie?
PIERARD, Gérald ULg; Franchimont, Claudine ULg; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2012), 67(9), 458-60

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations ... [more ▼]

For the media and the public at large, malignant melanoma is the most dreadful cancer of the skin. This statement is obvious. However, some nuances merit to be considered. The clinical presentations, histopathology and molecular genetics point to the fact that malignant melanoma is not a single monolithic pathological condition. Different types of melanomas are distinguished based on distinct origins and contrasted prognoses. The management and information for the patient should be handled individually. [less ▲]

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See detailLe melanome du sujet age.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2011), 66(1), 34-40

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are ... [more ▼]

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are more often affected, and chronic sun exposure is the main cause. The diagnosis relies on the clinical, dermoscopic and dermatopathologic examinations. Surgical excision is recommended but alternative treatments are possible in case of contra-indication. [less ▲]

Detailed reference viewed: 134 (4 ULg)