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See detailLa méta-analyse des recherches expérimentales en éducation
Leclercq, Dieudonné ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1986), mai

Le présent document est organisé autour d'une synthèse de divers travaux menés par J. Kulik et ses collègues du C.R.L.T. dont le LOGO oppose la progression irrégulière de l'individu (ligne brisée) à la ... [more ▼]

Le présent document est organisé autour d'une synthèse de divers travaux menés par J. Kulik et ses collègues du C.R.L.T. dont le LOGO oppose la progression irrégulière de l'individu (ligne brisée) à la courbe lisse de la progression collective (statistique) vers la maîtrise. [less ▲]

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See detailMeta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Anderson, Carl A; Boucher, Gabrielle; Lees, Charlie W et al

in Nature Genetics (2011), 43(3), 246-52

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association ... [more ▼]

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis. [less ▲]

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See detailMeta-Analysis in Transcriptional Network Inference
Meyer, Patrick ULg; Haibe-Kains, Benjamin; Bontempi, Gianluca

in Recomb Satellite 09 (2009)

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See detailMeta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Jones, Gregory; Tromp, Gerard; Kuivaniemi, Helena et al

in Circulation Research (2017)

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See detailA meta-analysis of isotopic compositions of North Sea marine mammals
Damseaux, France ULg; Lepoint, Gilles ULg; Das, Krishna ULg

Conference (2017, March 03)

For over a decade, the North Sea has been undergoing significant changes due to global changes and overfishing. We conducted meta-analyses of previously published data on marine mammals sampled in the ... [more ▼]

For over a decade, the North Sea has been undergoing significant changes due to global changes and overfishing. We conducted meta-analyses of previously published data on marine mammals sampled in the North Sea to test the competition for food sources and spatial variations. The overall objective of this study was to assess the potential trophic changes of the grey seal, the harbour seal and the harbour porpoise. Data included δ13C and δ15N values measured in blood cells and muscles from the three species. SIBER, a trophic niche overlap quantification approach, highlighted potential competition between marine mammal species. The ellipse drawn for harbour seal data showed the highest δ15N values, reflecting its trophic position at the top of the food web. But the ellipse overlapping between the harbour seal and the grey seal of Germany was very important, showing a potential strong competition for food sources may be due to the overfishing. The harbour porpoise displayed a lower trophic position and a wide range of δ13C and δ15N values compared to harbour seal and grey seal as seen from its extended ellipse size. This may be due to a more opportunistic behaviour following the decline of some fish population in the North Sea. Surprisingly a group of grey seals sampled in Scotland present a very small ellipse size, presumably more selective in their prey choice, and showed the lowest δ15N values. Caution should be taken before comparing the trophic position of the groups of grey seals as the baseline differed between the two sampling areas. Low nitrates concentrations, higher latitudes, colder temperatures, deeper waters and rocky soils of the Scotland’s coasts of the North Sea cause a stratification phenomenon of the water column explaining the lower δ15N baseline in this area and so the spatial variation between these two groups of grey seals living in the North Sea. [less ▲]

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See detailMeta-analysis of the effects of inhaled corticosteroids on bone in asthmatic and COPD patients
Richy, Florent; Bousquet, Jean; Devogelaer, Jean-Pierre et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 464

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See detailMeta-Cognitive Mystery Tales
Dechêne, Antoine ULg

Conference (2014, April)

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See detailMeta-learning of Exploration/Exploitation Strategies: The Multi-Armed Bandit Case
Maes, Francis; Wehenkel, Louis ULg; Ernst, Damien ULg

in Filipe, Joaquim; Fred, Ana (Eds.) Agents and Artificial Intelligence: 4th International Conference, ICAART 2012, Vilamoura, Portugal, February 6-8, 2012. Revised Selected Papers (2013)

The exploration/exploitation (E/E) dilemma arises naturally in many subfields of Science. Multi-armed bandit problems formalize this dilemma in its canonical form. Most current research in this field ... [more ▼]

The exploration/exploitation (E/E) dilemma arises naturally in many subfields of Science. Multi-armed bandit problems formalize this dilemma in its canonical form. Most current research in this field focuses on generic solutions that can be applied to a wide range of problems. However, in practice, it is often the case that a form of prior information is available about the specific class of target problems. Prior knowledge is rarely used in current solutions due to the lack of a systematic approach to incorporate it into the E/E strategy. To address a specific class of E/E problems, we propose to proceed in three steps: (i) model prior knowledge in the form of a probability distribution over the target class of E/E problems; (ii) choose a large hypothesis space of candidate E/E strategies; and (iii), solve an optimization problem to find a candidate E/E strategy of maximal average performance over a sample of problems drawn from the prior distribution. We illustrate this meta-learning approach with two different hypothesis spaces: one where E/E strategies are numerically parameterized and another where E/E strategies are represented as small symbolic formulas. We propose appropriate optimization algorithms for both cases. Our experiments, with two-armed “Bernoulli” bandit problems and various playing budgets, show that the metalearnt E/E strategies outperform generic strategies of the literature (UCB1, UCB1-T UNED, UCB-V, KL-UCB and epsilon-GREEDY); they also evaluate the robustness of the learnt E/E strategies, by tests carried out on arms whose rewards follow a truncated Gaussian distribution. [less ▲]

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See detailLe méta-projet de restauration des tourbières de Haute-Ardenne
Dufrêne, Marc ULg; Frankard, Philippe; Plunus, Julie et al

in Hautes Fagnes (2015), 300

Ce méta-projet synthétise les 6 projets de restauration des tourbières et des milieux associés (landes sèches, landes humides, bas-marais, prairies alluviales, aulnaies rivulaires, ...) qui ont été lancés ... [more ▼]

Ce méta-projet synthétise les 6 projets de restauration des tourbières et des milieux associés (landes sèches, landes humides, bas-marais, prairies alluviales, aulnaies rivulaires, ...) qui ont été lancés depuis 2003 en Wallonie. Ces projets se répartissent sur les différents hauts-plateaux ardennais, de la Croix-Scaille aux Hautes-Fagnes, en passant par les plateaux de Libin et de Recogne, de Saint-Hubert, des Tailles et de Spa-Malchamps. Les 5 projets (presque) terminés ont déjà permis de restaurer plus de 4.500 ha de zones tourbeuses et humides sur les Hauts-Plateaux ardennais et d'assurer la protection de plus de 2.700 ha de nouveaux territoires. [less ▲]

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See detailMetabolic Acidosis during Intracranial Surgery under Propofol or Sevoflurane Anesthesia
Schaub, Isabelle; Bonhomme, Vincent; Demoitie, Jeannick et al

in Anesthesiology (2008), 109(A475), 475

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See detailMetabolic acidosis during the first 2 weeks of life in VLBW infants receiving high protein intakes
SENTERRE, Thibault ULg; Rigo, J

in Intensive Care Medicine (2011), 37(S2), 397

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See detailMetabolic activity in external and internal awareness networks in severely brain-damaged patients.
Thibaut, Aurore ULg; Bruno, Marie-Aurélie ULg; Chatelle, Camille ULg et al

in Journal of Rehabilitation Medicine (2012), 44(6), 487-94

OBJECTIVE: An extrinsic cerebral network (encompassing lateral frontoparietal cortices) related to external/sensory awareness and an intrinsic midline network related to internal/self-awareness have been ... [more ▼]

OBJECTIVE: An extrinsic cerebral network (encompassing lateral frontoparietal cortices) related to external/sensory awareness and an intrinsic midline network related to internal/self-awareness have been identified recently. This study measured brain metabolism in both networks in patients with severe brain damage. DESIGN: Prospective [18F]-fluorodeoxyglucose-positron emission tomography and Coma Recovery Scale-Revised assessments in a university hospital setting. SUBJECTS: Healthy volunteers and patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS), minimally conscious state (MCS), emergence from MCS (EMCS), and locked-in syndrome (LIS). RESULTS: A total of 70 patients were included in the study: 24 VS/UWS, 28 MCS, 10 EMCS, 8 LIS and 39 age-matched controls. VS/UWS showed metabolic dysfunction in extrinsic and intrinsic networks and thalami. MCS showed dysfunction mostly in intrinsic network and thalami. EMCS showed impairment in posterior cingulate/retrosplenial cortices. LIS showed dysfunction only in infratentorial regions. Coma Recovery Scale-Revised total scores correlated with metabolic activity in both extrinsic and part of the intrinsic network and thalami. CONCLUSION: Progressive recovery of extrinsic and intrinsic awareness network activity was observed in severely brain-damaged patients, ranging from VS/UWS, MCS, EMCS to LIS. The predominance of intrinsic network impairment in MCS could reflect altered internal/self-awareness in these patients, which is difficult to quantify at the bedside. [less ▲]

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See detailMetabolic adaptation to prolonged exercise in severely obese subjects.
Scheen, André ULg; Pirnay, Freddy ULg; Luyckx, A. S. et al

in International Journal of Obesity & Related Metabolic Disorders (1983), 7(3), 221-9

In investigating the metabolic adaptation to prolonged exercise in markedly obese subjects, we compared blood glucose, plasma lactate, free fatty acids, insulin and glucagon concentrations during 3 h of ... [more ▼]

In investigating the metabolic adaptation to prolonged exercise in markedly obese subjects, we compared blood glucose, plasma lactate, free fatty acids, insulin and glucagon concentrations during 3 h of treadmill exercise in nine severely obese male patients (OB) (weight excess 84 +/- 7 per cent of their ideal body weight) and in nine healthy controls (C). Speed and slope of treadmill were selected to give a similar oxygen consumption in both groups (OB: 1.61 +/- 0.08 1/min; C: 1.72 +/- 0.07 1/min). Under these conditions, heart rate was similar in both groups, whereas ventilation was significantly lower in overweight subjects. In obese patients, plasma free fatty acid (FFA) levels were higher in the basal state (OB: 740 +/- 43 mumol/l; C: 602 +/- 40 mumol/l, 2 P less than 0.05) but showed a lower increase during the exercise period (OB: + 576 +/- 135 mumol/l; C: + 1071 +/- 100 mumol/l, 2 P less than 0.02). This impaired FFA mobilization was related to significantly higher insulin (IRI) levels throughout the exercise period as shown by the regression line of exercise-induced FFA increase (y, mumol/l) vs mean plasma IRI during exercise (x, microU/ml): y = 1238 - 60 x, r = -0.709, 2 P less than 0.001. Lack of glucagon increase could also contribute to the lower rise of FFA in obese subjects. A correspondingly increased contribution of carbohydrates to the energy supply is suggested by a significant decline in blood glucose and higher lactate plasma concentrations during the second half of the exercise period in overweight patients. These abnormalities could represent a metabolic limitation for performing prolonged exercise in markedly obese patients. [less ▲]

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See detailMetabolic alterations after a two-hour nocturnal interruption of a continuous subcutaneous insulin infusion.
Scheen, André ULg; Castillo, M.; Jandrain, Bernard ULg et al

in Diabetes Care (1984), 7(4), 338-42

In order to evaluate the metabolic consequences of a 2-h nocturnal interruption of continuous subcutaneous insulin infusion (CSII), seven insulin-dependent diabetic patients without residual insulin ... [more ▼]

In order to evaluate the metabolic consequences of a 2-h nocturnal interruption of continuous subcutaneous insulin infusion (CSII), seven insulin-dependent diabetic patients without residual insulin secretion were investigated. The changes in blood glucose, plasma free insulin, glucagon, free fatty acids, and 3-hydroxybutyrate (3 OH-B) concentrations have been compared during two randomized tests carried out either during the normal functioning of a Mill-Hill pump from 10 p.m. to 8 a.m. (1.00 +/- 0.06 U insulin/h, keeping adequate metabolic control) or during the same conditions but with a deliberate arrest of the pump between 11 p.m. and 1 a.m. Considering the value recorded at 11 p.m. as reference, interruption of the insulin infusion resulted in: (1) a rapid (already significant after 1 h) and sustained (maximal fall: --12.5 +/- 2.5 mU/L at 3 a.m.) decrease in plasma free insulin; (2) a delayed (significant after 4 h) and linear rise in blood glucose (maximal increase: + 4.0 +/- 1.3 mmol/L at 5 a.m.); (3) an early (significant at midnight) and prolonged rise in plasma free fatty acids (+ 387 +/- 148 mumol/L at 3 a.m.); (4) a delayed (significant after 3 h) and sustained increase in plasma 3 OH-B (+ 347 +/- 88 mumol/L at 3 a.m.); and (5) no significant changes in plasma glucagon. Thus, a 2-h interruption of CSII in resting nocturnal conditions is sufficient to induce significant, delayed, and sustained metabolic alterations in C-peptide-negative patients despite good baseline blood glucose control. Resetting the pump at its basal rate is insufficient to quickly restore adequate circulating insulin levels and effectively counteract the metabolic disturbances. The efficacy of a bolus insulin injection in these conditions should be evaluated. [less ▲]

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See detailMetabolic and cardiovascular consequences of strenuous concentric versus eccentric isokinetic exercise
Lehance, Cédric ULg; Bury, Thierry ULg; Maquet, Didier ULg et al

in Abstract Book “Exercise and muscle physiology” de l’Ecole Doctorale en Sciences de la Motricité (2006)

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