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See detailPulmonary function and tracheal dynamics during upper airway obstructive diseases in cattle
Lekeux, Pierre ULg; Art, Tatiana ULg

in Proceedings of the Fifth Veterinary Respiratory Symposium (1986, November 15)

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See detailPulmonary function as a potential limiting factor for health, production and exercise.
Lekeux, Pierre ULg

in Lekeux, Pierre (Ed.) Pulmonary Function in Healthy, Exercising and Diseased Animals (1993)

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See detailPulmonary function changes induced by experimental dichlorvos toxicosis in calves
Lekeux, Pierre ULg; Kyavu, A.; Clercx, Cécile ULg et al

in Research in Veterinary Science (1986), 40(3), 318-321

Clinical and pulmonary function changes induced by intravenous dichlorvos (2,2-dichlorvinyldimethyl phosphate) (DDVP) toxicosis, and reversibility of these changes after atropine treatment were ... [more ▼]

Clinical and pulmonary function changes induced by intravenous dichlorvos (2,2-dichlorvinyldimethyl phosphate) (DDVP) toxicosis, and reversibility of these changes after atropine treatment were investigated in six Friesian calves one to three months old. From one minute after dosage, all animals showed severe respiratory distress, excitation, weakness, muscle fasciculation and cholinesterase inhibition. Decrease in dynamic lung compliance and arterial oxygen tension and increase in total pulmonary resistance, viscous work of breathing and alveolar arterial oxygen gradient were highly significant (P less than 0.01). On the other hand, body secretions, heart rate, respiratory rate, tidal volume and arterial carbon dioxide tension were not significantly affected by DDVP injection. Atropine promptly and completely reversed these changes, except for muscle fasciculations, central depression and cholinesterase inhibition which disappeared progressively within 24 hours. [less ▲]

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See detailPulmonary function changes induced by three regimens of bronchodilating agents in calves with acute respiratory distress syndrome
Genicot, Bruno; Close, Roland; Lindsey, J. K. et al

in Veterinary Record : Journal of the British Veterinary Association (1995), 137(8), 183-186

Two aerosolised bronchodilators, one sympathomimetic and one parasympatholytic, were tested either alone or in combination for their ability to improve the pulmonary function of double-muscled calves ... [more ▼]

Two aerosolised bronchodilators, one sympathomimetic and one parasympatholytic, were tested either alone or in combination for their ability to improve the pulmonary function of double-muscled calves suffering from acute respiratory distress syndrome. In control animals treated with 0.9 per cent saline the parameters of pulmonary function and signs of clinical distress did not change significantly within the hour following the first treatment. Among the other animals, both at one hour and seven days after the first treatment, the most clinical improvement was observed in the animals treated with both bronchodilators and the least in the animals treated with clenbuterol hydrochloride. One hour after the first treatment the respiratory system compliance of the animals treated with ipratropium bromide and the arterial oxygen tension of the animals treated with both bronchodilators were significantly enhanced. After seven days the resistive parameters, the rectal temperature and the respiratory rate were also significantly improved in the animals treated with ipratropium bromide or both bronchodilators whereas only the respiratory rate and rectal temperature were significantly reduced in the animals treated with clenbuterol hydrochloride. [less ▲]

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See detailPulmonary Function in Healthy, Exercising and Diseased Animals
Lekeux, Pierre ULg

Book published by V. D. T. Publications (1993)

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See detailPulmonary function in the exercising horse
Art, Tatiana ULg; Bayly, W.; Lekeux, Pierre ULg

in Lekeux, Pierre (Ed.) Equine Respiratory Diseases, IVIS Ithaca NY (2002)

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See detailPulmonary function testing in calves : technical data
Lekeux, Pierre ULg; Hajer, R.; Breukink, H.J.

in American Journal of Veterinary Research (1984), 45(2), 342-345

Measurements of airflow (V), tidal volume (Vt), and intrapleural pressure (Ppl) were tested for accuracy in 5 healthy Dutch Friesian calves with an average body weight of 153 kg. A face mask was ... [more ▼]

Measurements of airflow (V), tidal volume (Vt), and intrapleural pressure (Ppl) were tested for accuracy in 5 healthy Dutch Friesian calves with an average body weight of 153 kg. A face mask was constructed, using fiberglass and polyester, taking into account the typical facial morphology of the calf. It was tested for airtightness, dead space, laminarity of the expiratory V, and absence of saliva into the pneumotachograph. Three different systems for measuring Ppl (pleura puncturing, esophageal balloon catheter, and esophageal saline solution-filled catheter) were tested in vitro, in a Woulfe's flask, and in vivo, in the 5 calves previously described. Moreover, Ppl measured at 3 different puncture sites of the thorax and at 3 different thoracic positions of the esophagus were compared. The frequency-response was flat to 5 Hz for the intrapleural needle and the balloon catheter, but not for the saline solution-filled catheter. The pulmonary function values obtained by puncture of the pleura at the right 9th intercostal space on a line running from the tuber coxae to the shoulder joint and by the esophageal balloon catheter, the balloon being positioned between the crossing point with the aorta and the 2 largest caudal mediastinal lymph nodes, did not differ significantly. The Ppl changes during normal breathing were greatest in the ventral site of the thorax and in the caudal thoracic portion of the esophagus, less in the dorsal site of the thorax and the middle thoracic portion of the esophagus, and least in the cranial site of the thorax and the cranial thoracic portion of the esophagus. When the balloon was positioned between the crossing point with the aorta and the 2 largest caudal mesiastinal lymph nodes, Ppl recordings showed a twice smaller variability than with the 2 other esophageal positions. [less ▲]

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See detailPulmonary Function Testing in Cattle: application of nuclear scintigraphy to evaluation of pulmonary function
Votion, Dominique ULg

in Pulmonary function in cattle (2000, April)

In contrast to other imaging techniques, scintigraphy provides information about the physiology of the lung rather than anatomical observations. As opposed to other pulmonary function tests, scintigraphy ... [more ▼]

In contrast to other imaging techniques, scintigraphy provides information about the physiology of the lung rather than anatomical observations. As opposed to other pulmonary function tests, scintigraphy provides regional evaluation instead of global measurement of lung function. This non-invasive imaging technique improves knowledge of the pathophysiologic processes involved in respiratory disorders. Furthermore, it is a sensitive method to early diagnosis of inflammatory process. It is also an unique tool to study the deposition of therapeutic aerosol within the respiratory tract. [less ▲]

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See detailPulmonary function testing in veterinary medicine
Lekeux, Pierre ULg; Close, R.; Art, Tatiana ULg

in Lekeux, Pierre (Ed.) Pulmonary Function in Healthy, Exercising and Diseased Animals (1993)

This paper describes the material and methods used for pulmonary function tests in unsedated domestic animals. The usefulness and clinical significance of these techniques are also analysed.

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See detailPulmonary function tests in exercising COPD horses
Art, Tatiana ULg; Anciaux, N.; Duvivier, D. H. et al

in Pflügers Archiv : European Journal of Physiology (1995), 430(16-16), 185

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See detailPulmonary Function Values and Growth in Belgian White and Blue Double-Muscled Cattle
Gustin, Pascal ULg; Bakima, M.; Art, Tatiana ULg et al

in Research in Veterinary Science (1988), 45(3), 405-410

Seventy-five double-muscled cattle of the Belgian white and blue breed, two days to 50 months old and weighing 45 to 680 kg, were investigated. Transpulmonary pressure changes, measured with an ... [more ▼]

Seventy-five double-muscled cattle of the Belgian white and blue breed, two days to 50 months old and weighing 45 to 680 kg, were investigated. Transpulmonary pressure changes, measured with an oesophageal balloon, variations of air flow and volume at the mouth were obtained during spontaneous breathing to calculate pulmonary function data. Oxygen and carbon dioxide tensions in arterial blood were also recorded. Growth related changes of the pulmonary function values were similar to those observed in other bovine breeds. Total pulmonary resistance, specific total pulmonary resistance, viscous work, power of breathing, specific viscous work, respiratory frequency and peak-to-peak change in transpulmonary pressure were greater in Belgian white and blue cattle than in Friesian cattle. In the former, tidal volume, specific tidal volume, lowest transpulmonary pressure during expiration, transpulmonary pressure at the functional residual capacity level, dynamic lung compliance and oxygen tension in arterial blood were smaller. Airflow, minute volume and carbon dioxide tension in arterial blood were similar in the Belgian white and blue and Friesian cattle. These results were related to the great sensitivity of double-muscled cattle of the Belgian white and blue breed to laryngitis and bronchopneumonia. [less ▲]

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See detailPulmonary Function Values in Friesian and Double-Muscled Calves During Acute Poikilocapnic Hypoxia
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1997), 44(2), 79-90

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian ... [more ▼]

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian White and Blue (BWB) breed known to develop more severe hypoxemia during exercise and respiratory diseases. Data were collected at 1 min intervals throughout the following protocol: breathing air (FIO2 = 21%), then breathing hypoxic gas mixture (FIO2 = 10%) for 5 min, and, finally, breathing air again for 5 min of recovery. Arterial blood was sampled at rest and at the 4th min of hypoxia for blood gas analysis. In HF and BWB calves, hypoxia induced a significant increase in tidal and minute volume, but did not change respiratory rate, dynamic lung compliance and total pulmonary resistance. However, with regard to their ventilation during normoxia at rest, BWB calves showed a comparatively greater rise in ventilation than HF calves during the first 4 min of hypoxia. On the contrary, by the 5th minute of hypoxia, ventilation of BWB calves declined to the normoxic level while HF calves largely sustained hyperventilation. This hypoxic ventilatory depression in BWB calves could be explained by the proportionately greater initial increase in ventilation. It was concluded that BWB calves supported this hypoxic challenge less easily than HF calves. [less ▲]

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See detailPulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentration after aerosol administration of cefquinome to horses
Art, Tatiana ULg; Ramery, Eve ULg; Fraipont, Audrey ULg et al

in Equine Veterinary Education (2010), 22(9), 473-479

The administration of antibiotics by aerosol to horses suffering from respiratory infections may partially circumvent the limitations of antimicrobial therapy, e.g. large injection volumes, low ... [more ▼]

The administration of antibiotics by aerosol to horses suffering from respiratory infections may partially circumvent the limitations of antimicrobial therapy, e.g. large injection volumes, low bioavailability and risk of diarrhea. Only injectable formulations are available currently and usually contain other substances that could irritate the mucosa and induce coughing and bronchospasm. In addition, the quality of the aerosol, particularly in terms of the delivery of antibiotics to the deep parts of the lung, is unknown. Although used under field conditions, cefquinome delivered by aerosol has never been studied in horses. This study examined the safety of cefquinome injectable solution, administered by aerosol at a dose of 225 mg/inhalation to 7 healthy horses, by assessing (1) pulmonary function before and 15 min after a single inhalation, at the first day (Day 1) and the fifth day (Day 5) of a 5 day period treatment; and (2) the inflammatory status of the lung, i.e. percentage neutrophils and myeloperoxidase concentration, based on bronchoalveolar lavage (BAL) at D1 and D5. In addition, cefquinome concentrations were measured in bronchoalveolar lavage fluid after aerosol, intravenous (i.v.) and intramuscular (i.m.) administrations. A single aerosol of cefquinome injectable solution did not induce any immediate nor delayed pulmonary side effects in healthy horses and produced cefquinome concentrations in bronchoalveolar lavage (BAL) within 30 min that were higher than the minimal inhibitory concentration of the main equine respiratory pathogens. These results should stimulate further studies, especially in horses suffering from bronchial hyper-reactivity. Aerosol delivery of antibiotics may well have a role in equine therapeutics. [less ▲]

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See detailPulmonary hydrostatic microvascular pressure changes and lung fluid balance during histamine infusion in intact dogs
D'Orio, Vincenzo ULg; RODRIGUEZ, LM; WAHLEN, C et al

in Circulatory Shock (1987), 22

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See detailPulmonary Impedance and Right Ventricular-Vascular Coupling in Endotoxin Shock
D'Orio, Vincenzo ULg; Lambermont, Bernard ULg; Detry, Olivier ULg et al

in Cardiovascular Research (1998), 38(2), 375-82

OBJECTIVE: We tested the hypothesis that right heart failure during endotoxin shock may result from altered ventriculovascular coupling responsible for impeding power transfer to the pulmonary circulation ... [more ▼]

OBJECTIVE: We tested the hypothesis that right heart failure during endotoxin shock may result from altered ventriculovascular coupling responsible for impeding power transfer to the pulmonary circulation. METHODS: The changes in vascular pulmonary input impedance and right ventricular contractility produced by low-dose endotoxin infusion were studied in 6 intact anesthetized dogs. RESULTS: Endotoxin insult resulted in pulmonary hypertension (from 22 +/- 2 to 33 +/- 3 mmHg) associated with significant decreases in stroke volume (from 26.9 +/- 4 to 20.2 +/- 3 ml) and right ventricular ejection fraction (from 41 +/- 3 to 32 +/- 2%). The first minimum of input impedance spectrum and zero phase were shifted towards higher frequencies. Input resistance and characteristic resistance were dramatically increased. The latter change contributed to a significant increase in the pulsatile component of total right ventricular power output from 13 to 21%, indicating a reduction in the hydraulic right ventricle power output delivered into the main pulmonary artery. Overall changes in input pulmonary impedance were indicative of increased afterload facing the right ventricle leading to depressed performance. In contrast, right ventricular systolic elastance was simultaneously increased from 0.56 to 0.93 mmHg/ml indicating an increase in right heart contractility. CONCLUSION: These data suggest that pulmonary hypertension in the setting of experimental endotoxin shock is accompanied by deleterious changes in the pulmonary impedance spectrum, which are responsible for a mismatch of increased contractile state of the right ventricle to the varying hydraulic load ultimately leading to ventricular-vascular uncoupling. [less ▲]

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See detailPulmonary mechanics and inductance plethysmography as noninvasive tools to detect a bilateral diaphragmatic paralysis in a pony
Amory, Hélène ULg; Lomba, F; Lekeux, Pierre ULg et al

in Proceedings of the 3d Congress of the World Equine Veterinary Association (1993)

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See detailPulmonary Mechanics During Treadmill Exercise in Race Ponies
Art, Tatiana ULg; Lekeux, Pierre ULg

in Veterinary Research Communications (1988), 12(2-3), 245-258

Exercise-induced variations in their ventilatory mechanics were studied in 8 healthy ponies 4.2 +/- 1.4 years old and weighing 282 +/- 11 kg. Airflow (V), tidal volume (VT), esophageal pressure, mask ... [more ▼]

Exercise-induced variations in their ventilatory mechanics were studied in 8 healthy ponies 4.2 +/- 1.4 years old and weighing 282 +/- 11 kg. Airflow (V), tidal volume (VT), esophageal pressure, mask pressure and electrocardiogram were simultaneously recorded before, during and after a treadmill (incline 8.3 degrees) exercise which consisted of 2 min walking (1.5 m.sec-1), 3 min slow trotting (3.0 m.sec-1) and 3 min fast trotting (3.5 m.sec-1). The results of three consecutive daily measurements were averaged for each pony. Heart rate, minute volume (Ve), respiratory frequency (f) and peak inspiratory and expiratory V, mean inspiratory and expiratory V, and peak to peak changes in transpulmonary pressure (maxdPtp) increased linearly and significantly with increasing velocity (v) (R2 = 0.99). Tidal volume and the inspiratory time to total breathing time ratio showed a curvilinar relation with v (R2 = 0.99). Minute volume, maxdPtp, total pulmonary resistance (RL) and VT increased from rest to fast trot 6.7, 5.7, 1.5 and 1.6 times respectively. When the ponies stopped all these values decreased significantly. After 5 min recovery, the Ve was approximately doubled, VT and max dPtp unchanged and RL 30% smaller than their respective resting values. The exercise-induced increase in Ve was achieved by an increase in f at both low and high intensity of work. [less ▲]

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See detailPulmonary mechanics in full term and prematurely born neonates during the first two weeks of life
Battisti, Oreste ULg; Lecart, C.; Guissard, F. et al

Conference (1992)

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See detailPulmonary perfusion redistribution in exercises horses
Votion, Dominique ULg; Harmegnies, N. F.; Duvivier, D. H. et al

in European Journal of Nuclear Medicine (2000), 41

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