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See detailREDUCING THE COST OF BALLAST TANK CORROSION - AN ECONOMIC MODELLING APPROACH
DE BAERE, Kris; Verstraelen, Helen; Rigo, Philippe ULg et al

in Marine Structures (2013)

Reducing the Cost of Ballast Tank Corrosion through Innovative Ship Design: an Economic Modeling Approach

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See detailReducing the uncertainty of hydrogeological parameters by co-conditional simulations: lessons from practical applications in aquifers and in low permeability layers
Dassargues, Alain ULg; Rentier, Céline; Huysmans, Marijke

in Calibration and Reliability in Groundwater Modelling: From Uncertainty to Decision Making (2006)

Stochastic simulation of aquifer heterogeneity is now often performed to provide a confidence interval of the modelled results for flow and solute transport problems. In practice, due to the few available ... [more ▼]

Stochastic simulation of aquifer heterogeneity is now often performed to provide a confidence interval of the modelled results for flow and solute transport problems. In practice, due to the few available measurements of the hydraulic conductivity (hard data), it is useful to integrate several other properties of the medium as indirect data (soft data). The additional conditioning obtained from the use of these secondary data allows reduction of the variance of the distribution and consequently decrease of the uncertainty of the results. This practice can also be extended to low permeability clay layers. For example, stochastic sequential simulation can be performed involving hydraulic conductivity values as hard data, and grain size measurements, electrical resistivity log, gamma ray log and a description of the lithology variation as soft data. However, other important properties can also be considered. The possible fracturing of clay strongly influences the flow and solute transport. On the other hand, in very low permeability media, diffusion can be considered as the dominant transport mechanism, so that heterogeneity in terms of the effective diffusion coefficient becomes important. Examples of application are summarized considering aquifers and low permeability clay layers. It clearly shows the great advantage of collecting multiple data sets of inter-correlated data on the same geological medium to be modelled. In high conductivity aquifers as well as in low permeability layers, this kind of additional conditioning obtained from various data is always useful when considering applications such as, among many others, well capture zones delineation, impact studies and geological confinement of wastes. [less ▲]

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See detailLa réduction chirurgicale de la masse tumorale des adénomes hypophysaires améliore le contrôle médical de l'acromégalie par les analogues de la Somatostatine
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in XXIème Congrès de la Société Française d'Endocrinologie - Abstract book (2004)

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See detailReduction comparable des nouveaux cas de diabete de type 2 sous sartan et sous inhibiteur de l'enzyme de conversion de l'angiotensine: comparaison des meta-analyses des essais prospectifs randomises.
Scheen, André ULg

in Revue Médicale de Liège (2005), 60(5-6), 424-8

This paper aims at comparing two meta-analyses of clinical trials having investigated the effect of the inhibition of the renin-angiotensin system either with an angiotensin converting enzyme inhibitor ... [more ▼]

This paper aims at comparing two meta-analyses of clinical trials having investigated the effect of the inhibition of the renin-angiotensin system either with an angiotensin converting enzyme inhibitor (ACEI) or with a selective angiotensin receptor blocker (ARB) on the incidence of new cases of type 2 diabetes mellitus in subjects with arterial hypertension or with congestive heart failure. The protection appears similar with ACEIs in six trials in a total of 24.623 patients (hazard ratio: 0.77; CI 95% 0.72-0.81; p < 0.00001 and with ARBs in five trials in a total of 14.344 patients (hazard ratio: 0.79; CI 95% 0.73-0.85; p < 0.00001). It is consistent whatever the comparator, a thiazide diuretic agent, a beta-blocker, a dihydropyridine calcium channel blocker or a placebo. The large ongoing ONTARGET controlled study will allow a direct comparison between an ACEI, ramipril, and an ARB, telmisartan, and will also investigate the potential benefit of a combined treatment with both drugs. The inhibition of the renin-angiotensin system should be considered among pharmacological strategies of prevention of type 2 diabetes mellitus. [less ▲]

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See detailLa réduction des frais d'alimentation des vaches laitières. Quelles possibilités à court et long termes ?
Beckers, Yves ULg

Conference given outside the academic context (2008)

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See detailRéduction des inégalités sociales de santé : quels défis éducatifs ? L'exemple du jeu
Absil, Gaëtan ULg; Vandoorne, Chantal ULg

in Education Santé (2012), (276), 8-12

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See detailLa réduction des luxations de l’épaule dans le De medicina de Celse
Marganne, Marie-Hélène ULg

in Sabah, Guy; Mudry, Philippe (Eds.) La médecine de Celse. Aspects historiques, scientifiques et littéraires (1994)

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See detailRéduction des rejets azotés chez le porc par l'alimentation.
Leterme, Pascal; Thewis, André ULg

in Efficience de l'azote en production végétale et animale, Journée d'Etude organisée par le Centre de Recherches Agronomiques et la Faculté Universitaire des Sciences Agronomiques (1997)

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See detailRéduction des troubles électrolytiques chez les prématurés <1250g
SENTERRE, Thibault ULg

in Storme, laurent (Ed.) Livres des communications. 18ème Journées Francophones de Recherche en Néonatologie (2012, December)

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See detailReduction du risque metabolique associe a l'obesite en modulant l'exposition tissulaire au cortisol.
Iovino, Alessandra ULg; Paquot, Nicolas ULg; Scheen, André ULg

in Revue Médicale Suisse (2010), 6(260), 1608-12

The 11-beta-hydroxysteroid dehydrogenase type 1 (11HSD1) enzyme promotes the local conversion from cortisone to cortisol, especially in the liver and the adipose tissue. It may play a role in the ... [more ▼]

The 11-beta-hydroxysteroid dehydrogenase type 1 (11HSD1) enzyme promotes the local conversion from cortisone to cortisol, especially in the liver and the adipose tissue. It may play a role in the pathophysiology of abdominal obesity and the metabolic syndrome, both showing some similarities with the Cushing syndrome. Considering experimental results obtained in rodents, the inhibition of this enzyme could exert favourable metabolic effects, with significant reductions in plasma glucose, insulin resistance and dyslipidaemia. Synthetic inhibitors of 11HSD1 are currently in development with encouraging preliminary results, first in animals, and more recently in humans. Selective inhibitors of 11HSD1 may represent an innovative approach in the pharmacological management of obesity, metabolic syndrome and type 2 diabetes in a near future. [less ▲]

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See detailLa réduction et le rapport des donations par voie d'assurance-vie
Moreau, Pierre ULg

in Leleu, Yves-Henri (Ed.) Le droit des personnes et des familles, Le droit administratif notarial, Le droit international privé, Actualités (2013)

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See detailReduction in bone remodelling markers with monthly oral ibandronate (150 mg) and weekly alendronate (70 mg): results from the motion study
Collette, Julien ULg; Reginster, Jean-Yves ULg; Zerbini, C. et al

in Osteoporosis International (2008, April), 19(Suppl.1), 207

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See detailReduction in fear reactions of isolated ewes and lambs by photographic images of conspecifics.
Bouissou, M. F.; Vandenheede, Marc ULg; Picard, M.

Conference (1996)

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See detailReduction in incidence of vertebral fractures with once yearly zoledronic acid in men with osteoporosis
Boonen, S.; Kaufman, J. M.; Reginster, Jean-Yves ULg et al

in Journal of Bone and Mineral Research (2011), 26(S1), 23

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See detailReduction in inter-hemispheric connectivity in disorders of consciousness.
Ovadia-Caro, Smadar; Nir, Yuval; Soddu, Andrea ULg et al

in PLoS ONE (2012), 7(5), 37238

Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC ... [more ▼]

Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challenges since patients are often behaviorally unresponsive. A promising new approach towards objective DOC diagnosis may be offered by the analysis of ultra-slow (<0.1 Hz) spontaneous brain activity fluctuations measured with functional magnetic resonance imaging (fMRI) during the resting-state. Previous work has shown reduced functional connectivity within the "default network", a subset of regions known to be deactivated during engaging tasks, which correlated with the degree of consciousness impairment. However, it remains unclear whether the breakdown of connectivity is restricted to the "default network", and to what degree changes in functional connectivity can be observed at the single subject level. Here, we analyzed resting-state inter-hemispheric connectivity in three homotopic regions of interest, which could reliably be identified based on distinct anatomical landmarks, and were part of the "Extrinsic" (externally oriented, task positive) network (pre- and postcentral gyrus, and intraparietal sulcus). Resting-state fMRI data were acquired for a group of 11 healthy subjects and 8 DOC patients. At the group level, our results indicate decreased inter-hemispheric functional connectivity in subjects with impaired awareness as compared to subjects with intact awareness. Individual connectivity scores significantly correlated with the degree of consciousness. Furthermore, a single-case statistic indicated a significant deviation from the healthy sample in 5/8 patients. Importantly, of the three patients whose connectivity indices were comparable to the healthy sample, one was diagnosed as locked-in. Taken together, our results further highlight the clinical potential of resting-state connectivity analysis and might guide the way towards a connectivity measure complementing existing DOC diagnosis. [less ▲]

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See detailReduction in PINP, a marker of bone metabolism, with raloxifene treatment and its relationship with vertebral fracture risk
Reginster, Jean-Yves ULg; Sarkar, S.; Zegels, Brigitte ULg et al

in BONE (2004), 34(2), 344-351

In the Multiple Outcomes of Raloxifene Evaluation (MORE) trial, 7705 postmenopausal women with osteoporosis, defined by low bone mineral density and/or prevalent vertebral fractures (VF), were randomized ... [more ▼]

In the Multiple Outcomes of Raloxifene Evaluation (MORE) trial, 7705 postmenopausal women with osteoporosis, defined by low bone mineral density and/or prevalent vertebral fractures (VF), were randomized to placebo or raloxifene (60 or 120 mg/day). All women received daily calcium (500 mg) and vitamin D (400-600 IU) supplements. Our previous analyses found that changes in BMD and biochemical markers of bone turnover are poorly predictive of the reduction in VF risk observed with raloxifene. This present study evaluated the effects of raloxifene on type I procollagen N-terminal propeptide (PINP), a new marker of bone turnover. Logistic regression analysis models evaluated the relationships between the changes at 1 year in PINP, serum osteocalcin (OC), bone-specific alkaline phosphatase (BSAP), and urinary excretion of type I collagen C-telopeptide fragments normalized to creatinine (CTx/Cr), and the risk of new VF at 3 years for placebo and pooled raloxifene. A subset of 967 women (mean age = 68 years) from the MORE cohort had PINP, OC, BSAP, and CTx evaluated at baseline. Both doses of raloxifene significantly decreased (P < 0.001) all biochemical markers of bone turnover from baseline. Compared to baseline, PINP levels were decreased by medians of 11.0% and 40.8% in the placebo and pooled raloxifene groups, respectively. In addition, the placebo and pooled raloxifene groups decreased serum OC by 8.5% and 31.8%, BSAP by 15.8% and 34.6%, and urinary CTx/Cr excretion by 5.6% and 46.5%, respectively, from baseline. In the pooled raloxifene group, the logistic regression relationship between 3-year VF risk and 1-year percentage change for each biochemical marker was statistically significant with PINP (slope estimate = 0.0085, P = 0.009), OC (slope estimate = 0.0068, P = 0.035), and BSAP (slope estimate = 0.0056, P = 0.039), but not with CTx/Cr (slope estimate = 0.0027, P = 0.192). Furthermore, the percent decrease in PINP at 1 year could account for 28% of the total reduction in vertebral fracture risk. In conclusion, a 1-year decrease in PINP, BSAP, or OC, but not CTx/Cr, may be predictive of the 3-year VF risk reduction with raloxifene therapy in this subset of postmenopausal women with osteoporosis. [less ▲]

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See detailReduction in Requirements for Allogeneic Blood Products: Pharmacologic Methods
Janssens, Marc ULg; Hartstein, Gary ULg; David, Jean-Louis ULg

in Annals of Thoracic Surgery (1996), 62(6), 1944-50

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic ... [more ▼]

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic antifibrinolytics. METHODS: A review of the literature was carried out to help the reader define the indications of these drugs during cardiopulmonary bypass operations, highlight the questions that remain concerning their indications and modes of action, and suggest future studies to answer these remaining questions. RESULTS: Prostacyclin reduces platelet trauma induced by extracorporeal circulation but does not effectively reduce postoperative bleeding and transfusion requirements. Desmopressin acts as a "glue," improving platelet adhesion, and may be effective when postoperative bleeding is excessive, but its routine use in cardiac operations cannot be recommended. Natural and synthetic antifibrinolytics inhibit plasmin and plasmin-induced platelet dysfunction. These agents have been shown to decrease bleeding and the need for allogeneic transfusions after open heart operations. However, with antifibrinolytic drugs, the risk of thromboembolic phenomena cannot be neglected. With aprotinin, this risk appears to be minimal when the drug is used at concentrations high enough to inhibit plasma kallikrein also. CONCLUSIONS: Prophylactic antifibrinolytics are efficacious, but their routine use remains controversial, both for economic reasons and for fear of thromboembolic complications. [less ▲]

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See detailReduction in the risk of back pain persists at least 30 months after discontinuation of teriparatide treatment: a meta-analysis
Reginster, Jean-Yves ULg; Nevitt, M. C.; Chen, P. et al

in Annals of the Rheumatic Diseases (2005, June), 64(Suppl.III), 521

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