Sustained fracture benefit with five years of risedronate in postmenopausal women

in BONE (2001), S28

Sustained NF-kB activity after removal of the etiologic agent in an animal model of asthma

in Proceedings: 1999 International Conference of the American Thoracic Society (1999)

Sustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis.

in Archives of Internal Medicine (2004), 164(18), 2024-30

BACKGROUND: Teriparatide (recombinant human parathyroid hormone [1-34]) reduces fracture risk in postmenopausal women with osteoporosis. We assessed the safety and incidence of new vertebral fractures ... [more ▼]

BACKGROUND: Teriparatide (recombinant human parathyroid hormone [1-34]) reduces fracture risk in postmenopausal women with osteoporosis. We assessed the safety and incidence of new vertebral fractures after withdrawal of teriparatide. METHODS: This study is a follow-up to the Fracture Prevention Trial (FPT), a randomized, placebo-controlled study of postmenopausal women with osteoporosis treated with teriparatide (20 or 40 microg) once daily for a mean of 18 months. More than 90% of the women remaining at the end of the FPT continued into the follow-up study (n = 1262). Patients and investigators were unblinded to original treatment group assignment. Women were treated according to standard clinical practice, including elective use of osteoporosis drugs. New vertebral fractures were determined by semiquantitative scoring of lateral thoracic lumbar spine radiographs 18 months after the end of the FPT. RESULTS: During the follow-up study, the reduction in fracture risk associated with previous treatment with teriparatide, 20 and 40 microg, was 41% (P = .004) and 45% (P = .001), respectively, vs placebo. The absolute reduction from the FPT baseline to the 18-month follow-up visit was 13% for both doses. Osteoporosis drugs were used by 47% of women during follow-up, with greater use in the former placebo group (P = .04); nevertheless, persistent fracture protection of previous teriparatide therapy was evident. Post hoc analysis also suggests that teriparatide treatment substantially reduced the increased risk of subsequent fracture in women who sustained a fracture during the FPT (P = .05). CONCLUSION: Vertebral fracture risk reduction by teriparatide administration persists for at least 18 months after discontinuation of therapy. [less ▲]

Sveconorwegian massif-type anorthosites and related granitoids result from post-collisional melting of a continental arc root

in Earth-Science Reviews (2011), 107

Swaged bolts: modelling of the installation process and numerical analysis of the mechanical behaviour

in Iványi, M.; Muzeau, J.-P.; Topping, B. H. V. (Eds.) Computational Steel Structures Technology (2000)

Swaged bolts are an alternative to high strength (HS) bolts for connections in steel structures. To clarify the different steps involved during their specific installation process, a numerical modelling ... [more ▼]

Swaged bolts are an alternative to high strength (HS) bolts for connections in steel structures. To clarify the different steps involved during their specific installation process, a numerical modelling has been carried out. It allows the relevant phenomena to be described and to be evaluated. This numerical calculation accounts for mechanical plasticity and friction contact between the components of swaged bolts. The finite element code "Lagamine" designed for the forming analysis that requires the modelling of the friction between plastically deformable solids has been used with an original and quite efficient way to take into account the contact. The drawing of the stress distributions during and after the swaging process is the main result of this research. [less ▲]

The SWAP EUV Imaging Telescope Part I: Instrument Overview and Pre-Flight Testing

in Solar Physics (2012)

The Sun Watcher with Active Pixels and Image Processing (SWAP) is an EUV solar telescope onboard ESA’s Project for Onboard Autonomy 2 (PROBA2) mission launched on 2 November 2009. SWAP has a spectral ... [more ▼]

The Sun Watcher with Active Pixels and Image Processing (SWAP) is an EUV solar telescope onboard ESA’s Project for Onboard Autonomy 2 (PROBA2) mission launched on 2 November 2009. SWAP has a spectral bandpass centered on 17.4 nm and provides images of the low solar corona over a 54 × 54 arcmin field-of-view with 3.2 arcsec pixels and an imaging cadence of about two minutes. SWAP is designed to monitor all space-weatherrelevant events and features in the low solar corona. Given the limited resources of the PROBA2 microsatellite, the SWAP telescope is designed with various innovative technologies, including an off-axis optical design and a CMOS–APS detector. This article provides reference documentation for users of the SWAP image data. [less ▲]

SWAP: a novel EUV telescope for space weather

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (2007, September 01)

The SWAP telescope (Sun Watcher using Active Pixel System detector and Image Processing) is being developed to be part of the PROBA2 payload, an ESA technological mission to be launched in early 2008 ... [more ▼]

The SWAP telescope (Sun Watcher using Active Pixel System detector and Image Processing) is being developed to be part of the PROBA2 payload, an ESA technological mission to be launched in early 2008. SWAP is directly derived from the concept of the EIT telescope that we developed in the '90s for the SOHO mission. Several major innovations have been introduced in the design of the instrument in order to be compliant with the requirements of the PROBA2 mini-satellite: compactness with a new of-axis optical design, radiation resistance with a new CMOS-APS detector, a very low power electronics, an athermal opto-mechanical system, optimized onboard compression schemes combined with prioritization of collected data, autonomy with automatic triggering of observation and off-pointing procedures in case of Solar event occurrence, ... All these new features result from the low resource requirements (power, mass, telemetry) of the mini-satellite, but also take advantage of the specificities of a modern technological platform, such as quick pointing agility, new powerful on-board processor, Packetwire interface and autonomous operations. These new enhancements will greatly improve the operations of SWAP as a space weather sentinel from a low Earth orbit while the downlink capabilities are limited. This paper summarizes the conceptual design, the development and the qualification of the instrument, the autonomous operations and the expected performances for science exploitation. [less ▲]

SWAP: Sun watcher with a new EUV telescope on a technology demonstration platform

in 5th International Conference on Space Optics (2004, June 01)

SWAP (SWAP (Sun Watcher using Active Pixel System detector and Image Processing) is an instrument that has been selected to fly on the PROBA-2 technology demonstration platform, a program of the European ... [more ▼]

SWAP (SWAP (Sun Watcher using Active Pixel System detector and Image Processing) is an instrument that has been selected to fly on the PROBA-2 technology demonstration platform, a program of the European Space Agency (ESA) to be launched in 2006. SWAP is based on an off-axis degraded Ritchey Chretien telescope that will image the EUV solar corona at 19.5 nm on a specifically fabricated extreme ultraviolet (EUV) sensitivity enhanced CMOS APS detector. The optical design and the optical coatings are derived from the Extreme Ultraviolet Imaging Telescope (EIT) operating on-board SOHO since 1995. It has been adapted for a single wavelength telescope with off-axis optics. It allows to use smaller optics and filters, with simple internal baffles avoiding external protruding parts. The superpolished optics will receive a multilayer coating that provides spectral selection centred on 19.5 nm and EUV reflectivity in normal incidence. This compact design is specifically adapted for accommodation on PROBA-2, where mass and envelope requirements are very stringent The SWAP PROBA-2 program will be an opportunity to demonstrate this new optical concept, while it will also validate space remote sensing with APS detectors, as well as on-board image processing capabilities. On the science outcomes, SWAP will provide solar corona images in the Fe XII line on a baselined 2-min cadence. Observations with this specific wavelength allow detecting phenomena, such as solar flares or 'EIT-waves', associated with the early phase of coronal mass ejections. The SWAP data will complement the observations provided by SOHO-EIT, and STEREO-SECCHI. [less ▲]

Swarming and swirling in self-propelled polar granular rods

in Physical Review Letters (2008), 100

Using experiments with anisotropic vibrated rods and quasi-2D numerical simulations, we show that shape plays an important role in the collective dynamics of self-propelled (SP) particles. We demonstrate ... [more ▼]

Using experiments with anisotropic vibrated rods and quasi-2D numerical simulations, we show that shape plays an important role in the collective dynamics of self-propelled (SP) particles. We demonstrate that SP rods exhibit local ordering, aggregation at the side walls, and clustering absent in round SP particles. Furthermore, we find that at sufficiently strong excitation SP rods engage in a persistent swirling motion in which the velocity is strongly correlated with particle orientation. [less ▲]

"Sweet Salgari" : Viaggio intorno alla maturità del capitano

in Le Reti di Dedalus : Rivista online del Sindacato Nazionale Scrittori (2012)