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Peer Reviewed
See detailPotential of the Migraine Disability Assessment (MIDAS) Questionnaire as a public health initiative and in clinical practice.
Edmeads, J.; Lainez, J. M.; Brandes, J. L. et al

in Neurology (2001), 56(6 Suppl 1), 29-34

Migraine is not always well managed in clinical practice, often being under-diagnosed and under-treated. As a result, many sufferers never consult a physician or lapse from care after physician contact ... [more ▼]

Migraine is not always well managed in clinical practice, often being under-diagnosed and under-treated. As a result, many sufferers never consult a physician or lapse from care after physician contact. Although most migraine care is provided by general practitioners, others, including specialists, emergency room physicians, pharmacists, and alternative practitioners, may also be involved. A method of standardizing clinical information about migraine is essential for coordinated, logical, and systematic care. The impact of migraine on the patient is an important clinical parameter but one that is seldom inquired about, perhaps because it exhibits such marked variability among and within individuals. Headache-related disability can be an objective and measurable index of this impact. The Migraine Disability Assessment (MIDAS) Questionnaire is a simple and validated instrument with potential for use in clinical practice, research, and public health. It can improve communication between patients and health-care professionals regarding the impact of migraine which, in turn, allows tailoring of the intensity of treatment to the severity of the illness. Changes in the MIDAS score may serve as an end point in assessing treatment efficacy. In populations, MIDAS scores may indicate the burden of migraine in the community and spark public health initiatives to improve management. [less ▲]

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See detailPotential of the NDSC in support of the Kyoto Protocol: Examples from the station Jungfraujoch, Switzerland
Zander, Rodolphe ULg; Mahieu, Emmanuel ULg; Servais, Christian ULg et al

in Van Ham, J.; Baede, A. P. M.; Guicherit, R. (Eds.) et al Non-CO2 Greenhouse Gases: Scientific Understanding, Control Options and Policy Aspects (2002)

This paper gives a brief description and “raison d’être” of the Network for the Detection of Stratospheric Change (NDSC) as well as its key research tasks to address the broader goal of monitoring ... [more ▼]

This paper gives a brief description and “raison d’être” of the Network for the Detection of Stratospheric Change (NDSC) as well as its key research tasks to address the broader goal of monitoring atmospheric changes and to identify their causes and related impacts on mankind’s environment. While the Network has primarily focussed, thus far, on monitoring the ozone layer and assessing global compliance with the Montreal Protocol, ongoing implementations and new capabilities have enabled it to adapt to more recent political developments such as the Kyoto Proto-col on substances affecting the climate system. Examples of activities in support of the latter are reported, based on infrared solar observations at the Jungfraujoch station. [less ▲]

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See detailPotential of using Daphnia magna (crustacea) developing in an aerated waste stabilisation pond as a commercial source of chitin
Cauchie, Henry-Michel ULg; Versali, Marie-France ULg; Hoffmann, L. et al

in Aquaculture (2002), 205(1-2), 103-117

The potential of using the planktonic crustacean Daphnia magna as a commercial source of chitin was studied on the basis of the estimation of the amount of chitin produced annually by this species and the ... [more ▼]

The potential of using the planktonic crustacean Daphnia magna as a commercial source of chitin was studied on the basis of the estimation of the amount of chitin produced annually by this species and the specifications of this kind of chitin. D. magna was found to have a significant chitin content, ranging from 3% to 7% of the body dry weight. During three consecutive years, chitin biomass (B) and daily somatic chitin production (daily P-SOM) were monitored in a 59,000-m(2) aerated waste stabilisation pond located in the Grand-Duchy of Luxembourg (Western Europe). These variables were found to vary a lot seasonally. Maximum values were observed in summer (B > 40 kg chitin; daily P-SOM > 20 kg chitin day(-1)). Annual somatic chitin production reached on average 1200 kg chitin year(-1). The amount of chitin generated by the moulting of the daphnids (i.e. chitin contained in the exuviae) can also constitute a significant source of chitin, reaching about 1220 kg chitin year(-1). Chitin was isolated from D. magna, following three different processing routes. The specifications of the isolated and purified chitin were similar to those of commercial chitin extracted from crabs and shrimps. The average molecular weight varied from 600,000 to 2,600,000 depending on the processing route, The isolated chitin had a low N content indicating a high degree of acetylation. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPotential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells
Grignet, Christine ULg; Calberg-Bacq, Claire-Michelle

in Gene Therapy (1997), 4

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See detailPOTENTIAL OF WATER RESOURCES OF PURSAT BASIN FOR IRRIGATION DEVELOPMENT
Ly, Sarann ULg; Someth, Paradis; Seng, Bunrith et al

in Tanji, Hajime (Ed.) Proceedings of the Second International Symposium on Sustainable Development in the Mekong River Basin (2006, September 18)

Pursat River, one of the tributaries, flows into the Great Lake Tonle Sap, located in Pursat province, 187 km from Phnom Penh. Pursat River originates in Kbal Kmaoch Mountain at an elevation of 1,425m ... [more ▼]

Pursat River, one of the tributaries, flows into the Great Lake Tonle Sap, located in Pursat province, 187 km from Phnom Penh. Pursat River originates in Kbal Kmaoch Mountain at an elevation of 1,425m. The main stream joins with Prey Khlong River and Arai River which originate in Orall Mountain at the elevation of 1,813m, the highest mountain in Cambodia. Large of paddy field in the province is irrigated by the river. The lack of year round management of irrigation system along the river is a serious constraint to social and economic development, and poverty reduction in the province. The objective of the research is to discover the appropriate way to develop the irrigation system along the river. The study attempts to uncover the historical development of the river and water use along the river. The research also reveals the appropriate way to put the right system to the right place. The analysis will review the estimation of river flow and total annual flow, an amount of water to be withdrawn from the river, which will be simulated based on meteorological and hydrologic data, and field investigation. [less ▲]

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See detailPotential paleoseismological records in the Western Gulf of Corinth sediments (Greece) for the last 500 years
Beckers, Arnaud ULg; Mortier, Clément; Beck, Christian et al

Conference (2013, November 06)

Related to the Gulf of Corinth rifting, five earthquakes of magnitude greater than 5.8 occurred in the last 35 years. Consequently, the question of earthquake (EQ) hazard is particularly relevant. Onland ... [more ▼]

Related to the Gulf of Corinth rifting, five earthquakes of magnitude greater than 5.8 occurred in the last 35 years. Consequently, the question of earthquake (EQ) hazard is particularly relevant. Onland paleoseismological data are scarce and offshore data were absent before the present study. We investigated recent sediments bounding three well-defined major seismogenic faults: Aegion, Trizonia and Psathopyrgos faults. We retrieved 12 gravity cores from 50 to 85 cm long in three distinct sites: the southern shelf (40 to 50 m deep), a 180 m deep sub-basin, and a transect from the southern coast to the center of the gulf. Chronology is based on 137Cs (Atmospheric Nuclear Experiments) and 210Pb decay for two sites (Aegion and Trizonia). Considering sedimentation rates estimates in these areas, the longer cores record about 500 years of sedimentary archives. We performed granulometry, magnetic susceptibility, loss on ignition and geochemical (X-Ray Fluorescence) measurements on cores from each site. Some samples were observed with a binocular to identify the nature of the grains. We sought to identify layers potentially attributed to EQ-related processes like liquefaction and tsunamis for the sites on the shelves or mass transport and turbidity currents for the basins. In Aegion, 3 coarser layers have been identified at identical depth in 3 cores across the scarp. 210Pb decay show erosion just under the first event, that we attributed to the 1995 tsunami (backwash deposit) (figure). In the Trizonia Sub-Basin, among 3 clear grain-size peaks, two have been attributed to the 1817 Aegion EQ and the 1660 Galaxidi EQ. In Psathopyrgos, 10 “events” (grain-size and Zr/Rb peaks) have been identified in the deepest part of the transect and at least 2 on the shelf. Their analysis is in progress. [less ▲]

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See detailPotential Physical And Chemical Barriers To Infection By The Burrowing Nematode Radopholus Similis In Roots Of Susceptible And Resistant Banana (Musa Spp.)
Wuyts, Nathalie; Lognay, Georges ULg; Verscheure, Marjolaine et al

in Plant Pathology (2007), 56(5), 878-890

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See detailPotential Proteomic Biomarkers Associated To Mucosal Healing In Crohn’s Disease
MEUWIS, Marie-Alice ULg; Baiwir, Dominique ULg; Mazzucchelli, Gabriel ULg et al

Poster (2014, October 06)

Introduction and objectives: In Crohn's disease (CD), there is a discrepancy between clinical activity of the disease (symptoms) and intestinal healing. However absence of tissue healing is associated ... [more ▼]

Introduction and objectives: In Crohn's disease (CD), there is a discrepancy between clinical activity of the disease (symptoms) and intestinal healing. However absence of tissue healing is associated with the risk of relapse and tissue damage progression. Endoscopy is costly and invasive. Hence biomarkers correlating with intestinal healing could improve disease management. We aimed to identify potential biomarkers associated to CD mucosal healing by a shotgun proteomics label free study. Methods: We used the STORI clinical trial cohort (n=103) aiming at identifying markers associated to relapse prediction after Infliximab treatment withdrawals. We used serum samples of patients in clinical remission, grouped according to the degree of intestinal healing seen at endoscopy. We performed depletion of the 20 most abundant plasma proteins on each serum pools and ran a proteomics label free differential analysis using 2D-nanoUPLC-MSE HDMS Synapt G1 for data acquisition and Protein Lynks Global Server vs 2.4 for data analysis (Waters, Corp., Milford, USA). Results and Discussion: We obtained potential biomarkers and designed a multiplexed -selected reaction monitoring (SRM) method for validation of these candidates in each individual patient. The method may also be tested in an independent set of IBD patients with and without mucosal healing. Conclusions: This research strategy and results of SRM validation of potential biomarkers associated to mucosal healing in this cohort of CD patients as well as the tests done on other CD patients, may provide new opportunities for CD follow-up tests development. [less ▲]

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See detailPotential research on marine mammals
Jauniaux, Thierry ULg; Coignoul, Freddy ULg

in Animal inside and outside the laboratory (2010)

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See detailA potential role for bat tail membranes in flight control
Gardiner, James D; Dimitriadis, Grigorios ULg; Codd, Jonathan R et al

in PLoS ONE (2011), 6(3), 18214

Wind tunnel tests conducted on a model based on the long-eared bat Plecotus auritus, indicated that the position of the tail membrane (uropatagium) can significantly influence flight control. Adjusting ... [more ▼]

Wind tunnel tests conducted on a model based on the long-eared bat Plecotus auritus, indicated that the position of the tail membrane (uropatagium) can significantly influence flight control. Adjusting tail position by increasing the angle of the legs relative to the body, has a two-fold effect; increasing leg-induced wing camber (i.e. locally increased camber and angle of attack of the inner wing surface) and increasing the angle of attack of the tail membrane. We also used our model to examine the effects of flying with and without a tail membrane. For the bat model with a tail membrane increasing leg angle increased the lift, drag and nose-down pitching moment produced. However, removing the tail membrane significantly reduced the change in pitching moment with increasing leg angle, but it had a much smaller effect on the level of lift and drag produced. The tail membrane, therefore, is potentially important for controlling the level of pitching moment produced by bats and an aid to flight control, specifically improving agility and manoeuvrability. Although the tail of bats is different from that of birds, in that it is only divided from the wings by the legs, it nonetheless, may, in addition to its prey capturing function, fulfil a similar role in aiding flight control. [less ▲]

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See detailPotential role of Alternaria and Cladosporium species in canine lymphoplasmacytic rhinitis
Mercier, Elise ULg; Peters, I.R.; Billen, Frédéric ULg et al

in Journal of Small Animal Practice (2013), 54 (4)

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See detailPotential Therapeutic Target Discovery by 2D-DIGE Proteomic Analysis in Mouse Models of Asthma
QUESADA CALVO, Florence ULg; Fillet, Marianne ULg; Renaut, Jenny et al

in Journal of Proteome Research (2011), 10(9), 4291-4301

As asthma physiopathology is complex and not fully understood to date; it is expected that new key mediators are still to be unveiled in this disease. The main objective of this study was to discover ... [more ▼]

As asthma physiopathology is complex and not fully understood to date; it is expected that new key mediators are still to be unveiled in this disease. The main objective of this study was to discover potential new target proteins with a molecular weight >20 kDa by using two-dimensional differential in-gel electrophoresis (2D-DIGE) on lung parenchyma extracts from control or allergen-exposed mice (ovalbumin). Two different mouse models leading to the development of acute airway inflammation (5 days allergen exposure) and airway remodeling (10 weeks allergen exposure) were used. This experimental setting allowed the discrimination of 33 protein spots in the acute inflammation model and 31 spots in the remodeling model displaying a differential expression. Several proteins were then identified by MALDI-TOF/TOF MS. Among those differentially expressed proteins, PDIA6, GRP78, Annexin A6, hnRPA3, and Enolase display an increased expression in lung parenchyma from mice exposed to allergen for 5 days. Conversely, Apolipoprotein A1 was shown to be decreased after allergen exposure in the same model. Analysis on lung parenchyma of mice exposed to allergens for 10 weeks showed decreased calreticulin levels. Changes in the levels of those different mediators were confirmed by Western blot and immunohistochemical analysis. Interestingly, alveolar macrophages isolated from lungs in the acute inflammation model displayed enhanced levels of GRP78. Moreover, intratracheal instillation of anti-GRP78 siRNA in allergen-exposed animals led to a decrease in eosinophilic inflammation and bronchial hyperresponsiveness. This study unveils new mediators of potential importance that are up- and down-regulated in asthma. Among up-regulated mediators, GRP-78 appears as a potential new therapeutic target worthy of further investigations. [less ▲]

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See detailPotential use of GFP microbial biosensors for the detection of mixing imperfections and cell viability in bioreactors
Delvigne, Frank ULg; Delafosse, Angélique ULg; Collignon, Marie-Laure ULg et al

Conference (2011, September 25)

The dynamics of microbial stress response in intensive cultivation conditions remains misunderstood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used as ... [more ▼]

The dynamics of microbial stress response in intensive cultivation conditions remains misunderstood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used as biosensors of the heterogeneities generated in a two-compartment scale-down reactor. The stress promoters have been chosen for their responsiveness to carbon limitation corresponding to the global substrate profiles encountered in intensive fed-batch cultures. From our results, it can be concluded that the exposure of microbial cells to substrates heterogeneities tends to decrease the GFP expression level in fed-batch mode. Fluorescence intensities have been monitored at the single cell level by using flow cytometry. During the course of the fed-batch culture, a drop at the level of the intracellular GFP content has been observed for the two scale-down operating conditions and for the two promoters sensitive to substrate limitation (rpoS and csiE). The fluorescence drop can be attributed to the repression of these promoters but also to the release of GFP to the extracellular medium according to the increase of the fluorescence level of the supernatant. This leakage has been observed for all the operating conditions, i.e. the scale-down reactors and the culture operating in the normal mode. Interestingly, GFP leakage is more pronounced in the case of the cultures operated in the normal mode. Indeed, staining by propidium iodide (PI) tends to be more elevated for the microbial cells cultured under the normal mode by comparison with those cultured in scale-down conditions, indicating a higher permeability of the membrane. These results are in accordance with previously published ones (Hewitt and co-workers) suggesting that microbial cells cultivated in heterogeneous bioreactors (scale-down and large-scale bioreactors) exhibits a higher viability level. These results suggest that GFP microbial biosensors could be used to detect simultaneously mixing imperfections and their impact on the viability of microorganisms. [less ▲]

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See detailPotential use of micro-array technology (bio-puce) in the diagnosis of inflammatory disorders in the horse
Lekeux, Pierre ULg; Thomas, A.; Ramery, Eve ULg et al

in XVII. Tagung über Pferdekrankheiten im Rahmen der EQUITANA (2007)

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See detailPotential use of mid-infrared milk spectrum in pregnancy diagnosis of dairy cows
Laine, Aurélie ULg; Goubau, Amaury; Dale, Laura-Monica et al

Conference (2013)

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See detailPotential use of mid-infrared milk spectrum in pregnancy diagnosis of dairy cows
Laine, Aurélie ULg; Goubau, Amaury; Dale, Laura-Monica et al

in Book of Abstracts of the 64th Annual Meeting of the European Federation of Animal Science (2013)

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See detailPotential use of milk mid-infrared spectra to predict individual methane emission of dairy cows
Dehareng, Frédéric; Delfosse, Camille; Froidmont, Eric et al

in Animal (2012), 6(10), 1694-1701

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See detailTHE POTENTIAL USE OF NEAR-INFRARED SPECTROSCOPY FOR THE QUALITY ASSESSMENT OF EGGS AND EGG PRODUCTS
GALIŞ, Anca; Dale, Laura ULg; Boudry, Christelle ULg et al

in Scientific Works. C Series. Veterinary Medicine (2012), LVIII(3), 294-307

In a context of high productivity, eggs’ quality assessment is necessary for enhanced safety and quality assurance towards the consumers and feedback for producers. The quality assessment of eggs and egg ... [more ▼]

In a context of high productivity, eggs’ quality assessment is necessary for enhanced safety and quality assurance towards the consumers and feedback for producers. The quality assessment of eggs and egg products is performed using destructive and time-consuming methods, therefore the use of rapid tools becomes mandatory, especially in the case of a high production rate. Near Infrared (NIR) spectroscopy is considered a very reliable and rapid technique with large use in food industry. At the farm level, NIR spectroscopy technique would be an interesting tool to determine the chemical and physical properties of eggs, eggshell and internal quality and, moreover, this information may help the layer farm manager when a problem occurs in the flock. Its application in the egg industry is aimed at the quality changes in eggs during storage and quality assessment of the egg products, through the compositional analysis. It is possible and in some cases successful the prediction and/or determination of different parameters such as: protein, total lipid and total solids content (for liquid egg products), polyunsaturated fatty acids (for freeze-dried egg yolk), moisture, fat and protein content (for spray-dried whole eggs). In addition, for the white colored shell eggs, the detection of blood and meat spots is also successful. Further studies with NIR and near infrared hyper spectral imaging system (NIR-HSI) are needed in this direction, as the results obtained until now are very promising for the development of a rapid tool for quality assessment of eggs and egg products. [less ▲]

Detailed reference viewed: 32 (6 ULg)