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See detailProinflammatory Cytokines Induce Bronchial Hyperplasia and Squamous Metaplasia in Smokers: Implications for chronic obstructive pulmonary disease therapy.
Herfs, Michael ULg; Hubert, Pascale ULg; POIRRIER, Anne-Lise ULg et al

in American Journal of Respiratory Cell and Molecular Biology (2012), 47(1), 67-79

Tracheobronchial squamous metaplasia is common in smokers and is associated with both airway obstruction in chronic obstructive pulmonary disease (COPD) and increased risk of lung cancer. Whereas this ... [more ▼]

Tracheobronchial squamous metaplasia is common in smokers and is associated with both airway obstruction in chronic obstructive pulmonary disease (COPD) and increased risk of lung cancer. Whereas this reversible epithelial replacement is almost always observed in association with chronic inflammation, the role of inflammatory mediators in the pathogenesis of squamous metaplasia is still unclear. In the present study, we investigated the implication of cigarette smoke-mediated pro-inflammatory cytokine up-regulation in the development and treatment of tracheobronchial epithelial hyperplasia and squamous metaplasia. By using immunohistological techniques, we showed a higher epithelial expression of TNFalpha, IL-1beta and IL-6 as well as an activation of NF-kappaB and AP-1/MAPK signalling pathways in the respiratory tract of smoking patients compared to the normal ciliated epithelium of non-smoking patients. In addition, we demonstrated that these signalling pathways strongly influence the proliferation and the differentiation state of in vitro generated normal human airway epithelial basal cells. Finally, we exposed mice to cigarette smoke for 16 weeks and demonstrated that anti-TNFalpha (etanercept), anti-IL-1beta (anakinra) and/or anti-IL-6R (tocilizumab) therapies significantly reduced epithelial hyperplasia and squamous metaplasia development. These data highlight the importance of soluble inflammatory mediators in the pathogenesis of tracheobronchial squamous metaplasia. Therefore, administration of pro-inflammatory cytokine antagonists may have clinical application in the management of COPD patients. [less ▲]

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See detailA proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: Oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition
Bureau, Fabrice ULg; Desmet, Christophe ULg; Burin Kefer, D. et al

in Journal of Immunology (2002), 168(10), 5318-5325

An anti-inflammatory role and therapeutic potential for cyclopentenone PGs (cyPGs) has been suggested, based on observations that levels of cyPGs in exudates increase during the resolution phase of ... [more ▼]

An anti-inflammatory role and therapeutic potential for cyclopentenone PGs (cyPGs) has been suggested, based on observations that levels of cyPGs in exudates increase during the resolution phase of inflammation, and that exogenous cyPGs may attenuate the inflammatory response in vivo and in vitro mainly through inhibition of NF-kappaB, a critical activator of inflammatory gene expression. However, exogenous cyPGs inhibit NF-kappaB only at concentrations substantially higher than those of endogenous cyPGs present in inflammatory fluids, thus challenging the hypothesis that cyPGs are naturally occurring inhibitors of inflammation and suggesting that cyPGs at low concentrations might have previously unappreciated effects. In this study, using various cell types, we report that cyPGs, when used at concentrations substantially lower than required for NF-kappaB inhibition (viz, low micromolar concentrations), significantly potentiate the inflammatory response to TNF-alpha. At these concentrations, cyPGs induce production of reactive oxygen species, thereby synergizing with TNF-alpha to activate the extracellular signal-regulated kinase 1/2, an activation which in turn potentiates proinflammatory cytokine expression at both transcriptional and posttranscriptional levels. Our studs establishes a proinflammatory role for cyPGs at low micromolar concentrations, raises the possibility that cyPGs do not act as physiologic anti-inflammatory mediators, and questions the therapeutic potential of these compounds. [less ▲]

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See detailProject as an awareness process making landscape
Occhiuto, Rita ULg

in Zagari, Franco (Ed.) Landscape as a project (2010)

Detailed reference viewed: 76 (9 ULg)
See detailThe project of 25 low-cost and low energy houses in Marchin (Belgium)
Dupagne, Albert ULg; Hauglustaine, Jean-Marie ULg

Conference (1983, November)

A first research funded by the Commission of the European Communities has led to a manual design methodology, mainly orientated to the conception of low-cost houses, integrating the fundamental thermal ... [more ▼]

A first research funded by the Commission of the European Communities has led to a manual design methodology, mainly orientated to the conception of low-cost houses, integrating the fundamental thermal concepts into the design process, without any use of sophisticated technology. The present paper concerns a practical application of this design methodology, used for a project of 25 low-energy houses designed, built and to be monitored. From the first design step until the detailed design, the research team has followed the objective to obtain houses having estimated heating energy needs 50 % lower than commonly, without any investment overrun, even on a difficult North sloped site. The design methodology has been an optimization tool of the volume, the plan, the North and South fenestration, the insulating material, etc. The construction elements were usual (for cost reasons), but their installation has been improved in a manner which allows a continuous control during the construction, giving no the guarantee to obtain thermal properties as close as possible to the expected ones. A detailed monitoring will measure the actual heating energy consumption and thus check the first evaluations. [less ▲]

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See detailProject Office - Final report
Warnant, René ULg

Report (2008)

Detailed reference viewed: 7 (0 ULg)
See detailProject Office - First synthetic report
Warnant, René ULg

Report (2007)

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See detailProject Office - Third synthetic report
Warnant, René ULg

Report (2008)

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See detailProject Office – Mid-term progress report
Warnant, René ULg

Report (2007)

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See detailPROJECT SCHEDULING WITH MODULAR PROJECT COMPLETION ON A BOTTLENECK RESOURCE
Coolen, Kris; Wenchao, Wei; Talla Nobibon, Fabrice ULg et al

Report (2011)

In this paper, we model a research-and-development project as consisting of several modules, with each module containing one or more activities. We examine how to schedule the activities of such a project ... [more ▼]

In this paper, we model a research-and-development project as consisting of several modules, with each module containing one or more activities. We examine how to schedule the activities of such a project in order to maximize the expected profit when the activities have a probability of failure and when an activity’s failure can cause its module and thereby the overall project to fail. A module succeeds when at least one of its constituent activities is successfully executed. All activities are scheduled on a scarce resource that is modeled as a single machine. We describe various policy classes, establish the relationship between the classes, develop exact algorithms to optimize over two different classes (one dynamic program and one branch-and-bound algorithm), and examine the computational performance of the algorithms on two randomly generated instance sets. [less ▲]

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See detailProjected inhibition of platelet aggregation with ticagrelor twice daily vs. clopidogrel once daily based on patient adherence data (the TWICE project)
Vrijens, Bernard ULg; Claeys, M.J.; LEGRAND, Victor ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 746-755

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained ... [more ▼]

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained when doses are delayed or missed. We compared the estimated inhibition of platelet aggregation (eIPA) for ticagrelor twice daily and clopidogrel once daily, based on their pharmacokinetic/ pharmacodynamic relationships and patient dosing history data. Methods Drug dosing histories of 5014 patients prescribed cardiovascular medications (primarily antihypertensive medicines) were extracted from an electronically compiled dosing history database. eIPA levels were simulated for 677 twice daily and 677 once daily dosing histories over a 30 day period, based on published onset/offset models for ticagrelor and clopidogrel IPA characteristics. Results While many patients treated twice daily missed at least one dose in 30 days, only 25.7% missed two consecutive doses. By comparison, 46.8% of patients treated once daily missed at least one dose. Simulations based on patient adherence over time showed that the average mean eIPA for ticagrelor twice daily remained significantly higher than for clopidogrel once daily (81.1% vs. 55.0%, P < 0.001). Ticagrelor twice daily patients had an eIPA below 10% for 0.20% of the 30 day period compared with 2.05% for clopidogrel once daily (P = 0.0001). Conclusions The projected level of platelet inhibition remained higher for ticagrelor twice daily than clopidogrel once daily, mainly due to the higher eIPA level achieved with ticagrelor and the relatively low likelihood of missing two consecutive twice daily doses. This modelling and simulation study suggests a therapeutic benefit of ticagrelor over clopidogrel when taking into account the most common dosing omissions. © 2013 The British Pharmacological Society. [less ▲]

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See detailProjectiles and hafting technology
Rots, Veerle ULg

in Iovita, Radu; Sano, Katsuhiro (Eds.) Multidisciplinary Approaches to the Study of Stone Age Weaponry (in press)

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See detailProjectiles and the abuse of the use-wear method in a search for impact
Rots, Veerle ULg; Plisson, Hugues

in Journal of Archaeological Science (2014), 48

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See detailProjecting Generation Decisions Induced by a Stochastic Program on a Family of Supply Curve Functions
Defourny, Boris ULg; Wehenkel, Louis ULg

Scientific conference (2007, March)

We propose to post-process the results of a scenario based stochastic program by projecting its decisions on a parameterized space of policies. By doing so the risk of overfitting to the set of scenarios ... [more ▼]

We propose to post-process the results of a scenario based stochastic program by projecting its decisions on a parameterized space of policies. By doing so the risk of overfitting to the set of scenarios used in the stochastic program is reduced. A proper choice of the structure of the space of policies allows one to exploit them in the context of novel scenarios, be it for Monte-Carlo based value estimation or for use in real-life conditions. These ideas are presented in the context of planning the exploitation of electric energy resources or for evaluating the economic value of a portfolio of assets. [less ▲]

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See detailProjection-débat autour d'Anita G. d'Alexander Kluge
Hamers, Jérémy ULg; Cormann, Grégory ULg

Conference given outside the academic context (2013)

Detailed reference viewed: 16 (8 ULg)
See detailProjections à l’échéance 2100 des changements de température et de précipitations en Belgique réalisées à l’aide des modèles du GIEC
Dury, Marie ULg

Master's dissertation (2008)

En 2007, le Groupe d’experts du GIEC a publié son 4e rapport (AR4) sur les changements climatiques. Les résultats proposés dans l’AR4 ont été obtenus à l’aide d’un vaste échantillon de modèles de ... [more ▼]

En 2007, le Groupe d’experts du GIEC a publié son 4e rapport (AR4) sur les changements climatiques. Les résultats proposés dans l’AR4 ont été obtenus à l’aide d’un vaste échantillon de modèles de circulation générale (AOGCMs) nouvellement homologués par le groupe. Notre travail a profité des avancées réalisées dans le monde de la modélisation climatique pour tenter de procéder à un état des lieux, remise à jour améliorée, des changements climatiques qui pourraient être enregistrés en Belgique au cours du 21e siècle en matière de température et de précipitations. Etant donné le large éventail de modèles mis à notre disposition, nous avons pu nous permettre d’écrémer ce vaste catalogue, ce que d’autres travaux antérieurs n’avaient pu faire. Ainsi, la première partie de cette étude est-elle consacrée à l’évaluation des différents AOGCMs dans le but de ne conserver que les plus aptes à réaliser des projections climatiques cohérentes pour notre territoire. La seconde partie de notre travail porte sur l’analyse des projections réalisées pour la Belgique par les huit modèles de circulation générale sélectionnés dans la partie précédente. Pour resituer les changements climatiques que les AOGCMs annoncent pour notre pays dans un contexte régional plus large, nous décrivons préalablement l’évolution climatique que connaîtra l’Europe au 21e siècle. Pour la Belgique, nous nous attachons à montrer les évolutions dans les moyennes annuelles et saisonnières pour les températures moyenne, minimale et maximale ainsi que pour les précipitations. Ensuite, nous tentons d’identifier les changements dans les statistiques journalières des évènements « extrêmes », ce qui, il faut le souligner, n’avait encore jamais été réalisé pour notre territoire. Ainsi, les évolutions dans le nombre de jours de gel, de jours de canicule, de vagues de chaleur,… et les changements dans la distribution des intensités des précipitations journalières ont été étudiés. [less ▲]

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See detailProjective and Affine Spatial Operators for Regions
Billen, Roland ULg; Clementini, Eliseo

in Joo Er, Meng; D'Attelis, Carlos; Mastorakis, M. (Eds.) Proceedings of WSEAS International Conferences MCBC, MCBE, ICAMSL, ICAI (2002, December)

Among Geographic Information Systems functionality is the retrieval of spatial data by using various spatial operators. The proposal of this paper is about the definition of new spatial operators that are ... [more ▼]

Among Geographic Information Systems functionality is the retrieval of spatial data by using various spatial operators. The proposal of this paper is about the definition of new spatial operators that are based on projective and affine geometric invariants. Such a special category of geometric properties, despite being not widely used in previous work, reveals itself a very interesting realm for the exploration of new operators that are both powerful and easy to use from an end-user perspective. [less ▲]

Detailed reference viewed: 19 (1 ULg)