Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailA pro-inflammatory role for the cyclopentenone prostaglandins at low concentrations: oxidative stress-induced ERK activation without NFKB inhibition
Bureau, Fabrice ULg; Desmet, Christophe ULg; Melotte, D. et al

in Proceedings : Congress "Cell signaling, transcription and translation as therapeutics targets" (2002)

Detailed reference viewed: 20 (7 ULg)
See detailPro-social behaviour in childhood : a psychosocial experimental approach
Born, Michel ULg; Stark, M. H.

Report (1989)

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailPro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency
Pernasetti, Flavia; Milner, Robert DG; al Ashwal, Abdullah A Z et al

in Journal of Clinical Endocrinology and Metabolism (1998), 83(6), 2079-83

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven ... [more ▼]

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors responsible for anterior pituitary development and pituitary-specific gene expression. Here, we describe seven children with GH, PRL, and TSH deficiency from three, reportedly unrelated, Middle Eastern families, harboring a newly recognized Pro- > Ser recessive mutation in codon 239 of the Pit-1 gene. The mutated residue is located at the beginning of the second alpha-helix of the POU-homeodomain and is strictly conserved among all POU proteins. The Pro239Ser mutant binds DNA normally but is unable to stimulate transcription. [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailProanthocyanidins from Ribes nigrum 1 Isolation and structure determination
Tits, Monique ULg; Angenot, Luc ULg; Warin, Roger et al

Poster (1992, May)

Detailed reference viewed: 2 (0 ULg)
Full Text
Peer Reviewed
See detailProanthocyanidins from Ribes nigrum 2. TLC Analysis
Tits, Monique ULg; Poukens, Pascale; Angenot, Luc ULg

Poster (1990, July)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailProanthocyanidins from Ribes nigrum leaves
Tits, Monique ULg; Poukens, Pascale; Angenot, Luc ULg

Poster (1992, May)

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailProanthocyanidins from Ribes nigrum leaves - Isolation and structure determination
Tits, Monique ULg; Angenot, Luc ULg; Warin, Roger et al

in Bulletin de Liaison Groupe Polyphenols (1992)

In summary, the antiinflammatory activity of Ribes nigrum leaves is mainly due to proanthocyanidins which are the major oligomers in the proanthocyanidins fraction

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailProanthocyanidins from Ribes nigrum leaves 1. Isolation and structure determination
Tits, Monique ULg; Angenot, Luc ULg; Warin, Roger et al

Poster (1990, July)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailProanthocyanidins from Ribes nigrum leaves : TLC Analysis
Tits, Monique ULg; Poukens, Pascale; Angenot, Luc ULg

in Bulletin de Liaison - Groupe Polyphenols (1992)

In summary, the main oligomeric prodelphinidins of Ribes nigrum leaves can be identified by HPTLC; this method could also be utilized as a proanthocyanidin screen for determining their occurrence in other ... [more ▼]

In summary, the main oligomeric prodelphinidins of Ribes nigrum leaves can be identified by HPTLC; this method could also be utilized as a proanthocyanidin screen for determining their occurrence in other plants and for quantification of the major dimers. [less ▲]

Detailed reference viewed: 118 (2 ULg)
Full Text
Peer Reviewed
See detailProanthocyanidins, from Ribes Nigrum Leaves, Reduce Endothelial Adhesion Molecules Icam-1 and Vcam-1
Garbacki, Nancy ULg; Kinet, Marie; Nusgens, Betty ULg et al

in Journal of Inflammation (London, England) (2005), 2

BACKGROUND: The effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro ... [more ▼]

BACKGROUND: The effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro. METHODS: In vivo studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs. Exudate volume and PMNs accumulation were measured. Leukocyte cell adhesion molecules (LFA-1, Mac-1 and VLA-4) mobilization in circulating granulocytes were analysed by flow cytometry and endothelial cell adhesion molecules (ICAM-1 and VCAM-1) were detected by immunohistochemistry on lung sections. In vitro studies were conducted on endothelial LT2 cells, stimulated with TNF-alpha, to evaluate ICAM-1, IL-8 and VEGF mRNA expression upon PACs treatment. Data sets were examined by one-way analysis of variance (ANOVA) followed by a Scheffe post-hoc test. RESULTS: Pretreatment of the animals with PACs (10, 30 and 60 mg/kg) inhibited dose-dependently carrageenin-induced pleurisy in rats by reducing pleural exudate formation and PMNs infliltration. Leukocyte cell adhesion molecules mobilization was not down-regulated on granulocytes by PACs. Immunohistochemistry on lung sections showed a decreased production of endothelial cell adhesion molecules. In vitro experiments demonstrated that PACs were able to significantly inhibit ICAM-1 but not IL-8 and VEGF165 mRNA expression. Moreover, VEGF121 mRNA expression was dose-dependently enhanced. CONCLUSION: This study provides evidence to support the anti-inflammatory activity of proanthocyanidins is related to an inhibition of leukocyte infiltration which can be explained at least in part by a down-regulation of endothelial adhesion molecules, ICAM-1 and VCAM-1 and that these compounds are capable of modulating TNF-alpha-induced VEGF transcription. [less ▲]

Detailed reference viewed: 33 (7 ULg)
Full Text
Peer Reviewed
See detailThe proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells.
Renert, Anne-Francoise; Leprince, Pierre ULg; Dieu, Marc et al

in Journal of Proteome Research (2009), 8(10), 4810-22

Ceramides are central molecules in sphingolipid metabolism. They are involved in the regulation of cancer-cell growth, differentiation, senescence and apoptosis. To better understand how these secondary ... [more ▼]

Ceramides are central molecules in sphingolipid metabolism. They are involved in the regulation of cancer-cell growth, differentiation, senescence and apoptosis. To better understand how these secondary messengers induce their biological effects, adenocarcinoma cells (HCT116) were treated with exogenous long-chain ceramides (C16-ceramide) in order to mimic endogenous sphingolipids. This treatment induced a decrease of cell viability partly due to apoptosis as shown by PARP cleavage and a decrease of pro-caspase 3. Two-dimensional differential in-gel electrophoresis (2D-DIGE) revealed the differential expression of 51 proteins in response to C16-ceramide. These proteins are notably involved in cell proliferation, apoptosis, protein transport and transcriptional regulation. Among them, the cell death-promoting factor Btf was found to be implicated in the apoptotic signal triggered by ceramide. In adenocarcinoma cells, Btf regulates apoptosis related proteins such as Mdm2, p53, BAX and pBcl-2 and thus plays an important role in the ceramide mediated cell death. These findings bring new insight into the proapoptotic ceramide-dependent signaling pathway. [less ▲]

Detailed reference viewed: 79 (23 ULg)
Peer Reviewed
See detailA Probabilistic Approach to Integrating Multiple Cues in Visual Tracking
Du, Wei ULg; Piater, Justus ULg

in 10th European Conference on Computer Vision (2008)

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailA probabilistic approach to power system network planning under uncertainties
Vassena, Stefano; Mack, Philippe; Druet, Christophe et al

in Proceedings of the IEEE Bologna Power Tech Conference (2003)

This work proposes a methodology and a practical tool for the study of long-term network planning under uncertainties. In this approach the major external uncertainties during the planning horizon are ... [more ▼]

This work proposes a methodology and a practical tool for the study of long-term network planning under uncertainties. In this approach the major external uncertainties during the planning horizon are modeled as macroscenarios at different future time instants. On the other hand, the random nature of actual operating conditions is taken into account by using a probabilistic model of microscenarios based on past statistics. Massive Monte-Carlo simulations are used to generate and simulate a large number of scenarios and store the detailed results in a relational database. Data mining techniques are then applied to extract information from the database so as to rank scenarios and network reinforcements according to different criteria. [less ▲]

Detailed reference viewed: 24 (4 ULg)
Full Text
Peer Reviewed
See detailProbabilistic Assessment of Lifetime of Low-Earth-Orbit Spacecraft: Uncertainty Propagation and Sensitivity Analysis
Dell'Elce, Lamberto ULg; Kerschen, Gaëtan ULg

in Journal of Guidance Control & Dynamics (2014)

This paper is devoted to the probabilistic uncertainty quantification of orbital lifetime estimation of low-altitude satellites. Specifically, given a detailed characterization of the dominant sources of ... [more ▼]

This paper is devoted to the probabilistic uncertainty quantification of orbital lifetime estimation of low-altitude satellites. Specifically, given a detailed characterization of the dominant sources of uncertainty, we map this input into a probabilistic characterization of the orbital lifetime through orbital propagation. Standard Monte Carlo propagation is first considered. The concept of drag correction is then introduced to facilitate the use of polynomial chaos expansions and to make uncertainty propagation computationally effective. Finally, the obtained probabilistic model is exploited to carry out stochastic sensitivity analyses, which in turn allow gaining insight into the impact uncertainties have on orbital lifetime. The proposed developments are illustrated using one CubeSat of the QB50 constellation. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailProbabilistic Assessment of the Lifetime of Low-Earth-Orbit Spacecraft: Uncertainty Characterization
Dell'Elce, Lamberto ULg; Arnst, Maarten ULg; Kerschen, Gaëtan ULg

in Journal of Guidance Control & Dynamics (2014)

Orbital lifetime estimation is a problem of great timeliness and importance in astrodynamics. In view of the stochastic nature of the thermosphere and of the complexity of drag modeling, any deterministic ... [more ▼]

Orbital lifetime estimation is a problem of great timeliness and importance in astrodynamics. In view of the stochastic nature of the thermosphere and of the complexity of drag modeling, any deterministic assessment of orbital lifetime is likely to be bound to failure. This is why the present paper performs uncertainty quantification of satellite orbital lifetime estimation. Specifically, this paper focuses on the probabilistic characterization of the dominant sources of uncertainty inherent to low-altitude satellites. Uncertainties in the initial state of the satellite and in the atmospheric drag force, as well as uncertainties introduced by modeling limitations associated with atmospheric density models, are considered. Mathematical statistics methods, in conjunction with mechanical modeling considerations, are used to infer the probabilistic characterization of these uncertainties from experimental data and atmospheric density models. This characterization step facilitates the application of uncertainty propagation and sensitivity analysis methods, which in turn allows gaining insight into the impact that these uncertainties have on the orbital lifetime. The proposed developments are illustrated using one CubeSat of the QB50 constellation. [less ▲]

Detailed reference viewed: 38 (24 ULg)
See detailA probabilistic characterization, propagation, and sensitivity analysis of uncertainties in a metal forming application
Arnst, Maarten ULg; Ponthot, Jean-Philippe ULg

Conference (2013, September 05)

In metal forming processes, after leaving the tooling, formed pieces of metal have a tendency to partially return to their original shape because of their elastic recovery. This phenomenon, referred to as ... [more ▼]

In metal forming processes, after leaving the tooling, formed pieces of metal have a tendency to partially return to their original shape because of their elastic recovery. This phenomenon, referred to as the springback, is quite complex and depends not only on material properties such as Young's modulus and yield stress but also on many process parameters such as sheet thickness and bending angles. The springback is difficult to predict and is a major quality concern in forming processes because when the springback is smaller or larger than expected, it can cause serious problems to subsequent assembly processes due to geometry mismatches. In this communication, we present a probabilistic analysis of a metal forming application. We consider the bending of a metal sheet with uncertain elastoplastic material properties. First, we use methods from mathematical statistics to obtain a probabilistic characterization of the elastoplastic material properties from data. Next, we map this probabilistic representation of the elastoplastic material properties into a probabilistic representation of the deformed shape of the metal sheet through a mechanical model implemented using the Metafor software. Finally, we conduct a stochastic sensitivity analysis to determine which elastoplastic material properties are most influential in driving uncertainty in the deformed shape after the springback. Our probabilistic analysis involves so called nonintrusive methods, that is, methods that can be implemented as wrappers around the Metafor software without requiring modification of its source code. Further, it includes recent methods for the propagation and sensitivity analysis of uncertainties characterized by arbitrary probability distributions that may exhibit statistical dependence. [less ▲]

Detailed reference viewed: 24 (5 ULg)
Full Text
Peer Reviewed
See detailProbabilistic design of power-system special stability controls
Wehenkel, Louis ULg; Lebrevelec, Cyril; Trotignon, Marc et al

in Control Engineering Practice (1999), 7(2), 183-194

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and ... [more ▼]

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and fast dynamics, and modeling uncertainties. A large number of scenarios are simulated in parallel by time-domain numerical integration, and the relevant parameters of the resulting system trajectories are stored in a database. Data-mining tools are used to identify the most important system weaknesses and possible improvements. The approach is tested on a large-scale study on the SouthÐEastern part of the extra-high-voltage system of Electricité de France. [less ▲]

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detailProbabilistic Electromechanical Modeling of Nanostructures with Random Geometry
Arnst, Maarten ULg; Ghanem, Roger

in Journal of Computational and Theoretical Nanoscience (2009), 6(10), 2256-2272

This article is concerned with the probabilistic modeling of the electromechanical behavior of nanostructures to assess the effect of variations in geometrical characteristics on the device performance ... [more ▼]

This article is concerned with the probabilistic modeling of the electromechanical behavior of nanostructures to assess the effect of variations in geometrical characteristics on the device performance. The topological uncertainty that may be present in the position of the boundaries of nanostructures is accommodated by treating these boundaries as stochastic processes. It is shown how the probabilistic electromechanical models thus obtained can be discretized with the help of Galerkin projections on polynomial chaos expansions. An illustration is provided to demonstrate the proposed framework. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailProbabilistic equivalence and stochastic model reduction in multiscale analysis
Arnst, Maarten ULg; Ghanem, Roger

in Computer Methods in Applied Mechanics & Engineering (2008), 197(43-44), 3584-3592

This paper presents a probabilistic upscaling of mechanics models. A reduced-order probabilistic model is constructed as a coarse-scale representation of a specified fine-scale model whose probabilistic ... [more ▼]

This paper presents a probabilistic upscaling of mechanics models. A reduced-order probabilistic model is constructed as a coarse-scale representation of a specified fine-scale model whose probabilistic structure can be accurately determined. Equivalence of the fine- and coarse-scale representations is identified such that a reduction in the requisite degrees of freedom can be achieved while accuracy in certain quantities of interest is maintained. A significant stochastic model reduction can a priori be expected if a separation of spatial and temporal scales exists between the fine- and coarse-scale representations. The upscaling of probabilistic models is subsequently formulated as an optimization problem suitable for practical computations. An illustration in stochastic structural dynamics is provided to demonstrate the proposed framework. [less ▲]

Detailed reference viewed: 26 (7 ULg)
Full Text
Peer Reviewed
See detailA Probabilistic Framework for 3D Visual Object Representation
Detry, Renaud ULg; Pugeault, Nicolas; Piater, Justus ULg

in IEEE Transactions on Pattern Analysis & Machine Intelligence (2009)

Detailed reference viewed: 38 (12 ULg)