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See detailProlactin/growth hormone-derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis
Nguyen, Ngoc-Quynh-Nhu ULg; Tabruyn, Sébastien ULg; Lins, Laurence ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2006), 103(39), 14319-14324

Angiogenesis is a crucial step in many pathologies, including tumor growth and metastasis. Here, we show that tilted peptides exert antiangiogenic activity. Tilted (or oblique-oriented) peptides are short ... [more ▼]

Angiogenesis is a crucial step in many pathologies, including tumor growth and metastasis. Here, we show that tilted peptides exert antiangiogenic activity. Tilted (or oblique-oriented) peptides are short peptides known to destabilize membranes and lipid cores and characterized by an asymmetric distribution of hydrophobic residues along the axis when helical. We have previously shown that 16-kDa fragments of the human prolactin/growth hormone (PRL/GH) family members are potent angiogenesis inhibitors. Here, we demonstrate that all these fragments possess a 14-aa sequence having the characteristics of a tilted peptide. The tilted peptides of human prolactin and human growth hormone induce endothelial cell apoptosis, inhibit endothelial cell proliferation, and inhibit capillary formation both in vitro and in vivo. These antiangiogenic effects are abolished when the peptides' hydrophobicity gradient is altered by mutation. We further demonstrate that the well known tilted peptides of simian immunodeficiency virus gp32 and Alzheimer's beta-amyloid peptide are also angiogenesis inhibitors. Taken together, these results point to a potential new role for tilted peptides in regulating angiogenesis. [less ▲]

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See detailProlactine triggers a pro-inflamatory response in bovine mammary epithelial cells
Boutet, Philippe ULg; Sulon, Joseph; Detilleux, Johann ULg et al

in Proceedings: 24th World Buiatrics Congress (2006)

Detailed reference viewed: 32 (3 ULg)
See detailLa Prolactine
Beckers, Albert ULg

Scientific conference (1994, September 22)

Detailed reference viewed: 2 (0 ULg)
See detailProlactinomas
Ciccarelli, A.; Beckers, Albert ULg

in 14th EFES Postgraduate Course in Clinical Endocrinology - Abstract book (2005)

See detailProlactinomas : Advances in Treatment of Endocrine Diseases
Beckers, Albert ULg

Scientific conference (2005, November)

Detailed reference viewed: 4 (0 ULg)
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See detailProlactinomas Resistant to Standard Doses of Cabergoline : A multicenter study of 92 patients
VROONEN, Laurent ULg; Jaffrain-Rea, ML; PETROSSIANS, Patrick ULg et al

in European Journal of Endocrinology (2012), 167

Detailed reference viewed: 41 (9 ULg)
See detailLes prolactinomes résistants aux agents dopaminergiques
Beckers, Albert ULg; Tamagno, J. L.

Scientific conference (2006, December 15)

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See detailProlactinomes résistants aux dopaminergiques
Beckers, Albert ULg

Scientific conference (2011, May 27)

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See detailProlégomènes à l'étude de la Schola du Trajan à Ostie.
Morard, Thomas ULg; Wavelet, David

in Mélanges de l'Ecole Française de Rome. Italie et Méditérranée (2002), 114(2), 759-815

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See detail"Prolégomènes à l'études du monologue"
Defays, Jean-Marc ULg

in Humoresques (Association pour le développement des recherches sur le Comique, le Rire et l'Humour) (2011), (33), 23-37

Detailed reference viewed: 26 (1 ULg)
See detailProlégomènes à une étude de la modalité en néo-égyptien
Polis, Stéphane ULg

Master's dissertation (2004)

Detailed reference viewed: 22 (6 ULg)
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See detailProlégomènes à une philosophie de la médiation
Bachelet, Jean-François ULg

in Castelain, Bernard (Ed.) De l'autre côté du conflit: la médiation (2013)

Detailed reference viewed: 26 (4 ULg)
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See detailProlégomènes à une théorie unifiée de la temporalité en égyptien
Winand, Jean ULg

in Proceedings of the Seventh International Congress of Egyptologists (1998)

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See detailProlepsis : Foreword
Longrée, Dominique ULg; Halla-Aho, Hilla

in De Lingua Latina : Revue de Linguistique Latine du Centre Alfred Ernout (2012), 7

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See detailProliferation generation of auditory hair cells in culture
Malgrange, B; Belachew, S; Thiry, Marc ULg et al

in Acta Oto-Rhino-Laryngologica Belgica (2002), 56

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See detailProliferative generation of mammalian auditory hair cells in culture
Malgrange, Brigitte ULg; Belachew, Shibeshih ULg; Thiry, Marc ULg et al

in Mechanisms of Development (2002), 112(1-2), 79-88

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See detailThe proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction.
Dumez, Marie-Eve ULg; Herman, Julie; Campisi, Vincenzo ULg et al

in PloS one (2013), 8(9), 68014

The majority of proteases are synthesized in an inactive form, termed zymogen, which consists of a propeptide and a protease domain. The propeptide is commonly involved in the correct folding and specific ... [more ▼]

The majority of proteases are synthesized in an inactive form, termed zymogen, which consists of a propeptide and a protease domain. The propeptide is commonly involved in the correct folding and specific inhibition of the enzyme. The propeptide of the house dust mite allergen Der p 3, NPILPASPNAT, contains a proline-rich motif (PRM), which is unusual for a trypsin-like protease. By truncating the propeptide or replacing one or all of the prolines in the non-glycosylated zymogen with alanine(s), we demonstrated that the full-length propeptide is not required for correct folding and thermal stability and that the PRM is important for the resistance of proDer p 3 to undesired proteolysis when the protein is expressed in Pichia pastoris. Additionally, we followed the maturation time course of proDer p 3 by coupling a quenched-flow assay to mass spectrometry analysis. This approach allowed to monitor the evolution of the different species and to determine the steady-state kinetic parameters for activation of the zymogen by the major allergen Der p 1. This experiment demonstrated that prolines 5 and 8 are crucial for proDer p 3-Der p 1 interaction and for activation of the zymogen. [less ▲]

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See detailPrólogo
Willson, Patricia ULg

in Paul Ricoeur, Sobre la traducción (2005)

Detailed reference viewed: 15 (4 ULg)