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See detailLes prostaglandines : biosynthèse et pharmacologie
Hanzen, Christian ULg

in Annales de Médecine Vétérinaire (1983), 127

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See detailProstaglandines et cycle sexuel chez les animaux domestiques
Derivaux, Jules; Ectors, Francis ULg; Beckers, Jean-François ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1976), 131

In some domestic animal species, cow, ewe, sow, mare, luteal regression and therefore oestral regulation, depends on the action of a luteolytic of uterine origin. This luteolysine should be but a ... [more ▼]

In some domestic animal species, cow, ewe, sow, mare, luteal regression and therefore oestral regulation, depends on the action of a luteolytic of uterine origin. This luteolysine should be but a prostaglandin F2 alpha or an analogue. Progesterone is the regulator of the cycle; plasma level is low (basic level) at day of oestrus (0,5ng/ml) then increases gradually to reach a peak value of 6 to 9 ng/ml at days 6 to 16 of the cycle. Beta-oestradiol level fluctuates including a main peak before ovulation (9 pg/ml) and three accessory peaks at days 4-5, 8, 12-14 of the cycle; however the peak of the 8th day is inconstant. FSH and LH levels are constant during dioestrus, peak level values are observed at the beginning of oestrus, they are practically superposed and of a 6 to 9 hours duration. Administration of prostaglandins during luteal phase produces hormonal changes similar to those observed during the normal cycle. Because of its luteolytic action and its effect on uterine fibre, prostaglandin F2 alpha offers a special interest for stock farming and veterinary medicine. So a full expression can be given to AI and a more extended application of egg transfer can be foreseen. It constitutes an effective therapy in the case of corpus luteum persistence and a way to induce parturition. [less ▲]

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See detailProstaglandines et physiologie de la reproduction humaine et animale.
Hanzen, Christian ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1984), 13(4), 351-61

This review of 417 publications in the literature covers various aspects of the role of prostaglandins in human and animal reproductive physiology. The author points out that there are a variety of ... [more ▼]

This review of 417 publications in the literature covers various aspects of the role of prostaglandins in human and animal reproductive physiology. The author points out that there are a variety of prostaglandins all belonging to a family of substances that derive from arachadonic acid. They are present in many human and animal tissues, are extremely labile and are involved in reproduction in the ovary in follicular development and release of the follicle, in the tube in migration of the gametes, and in the uterus in implantation and delivery. The author says that the role of prostaglandins is not an exclusive one but they are linked with the hypothalamo-pituitary hormones, as well as with progesterone and oestrogens. It may be possible that PGE helps to initiate follicular development by stimulating the appearance of LH and FSH receptors. PGE is also luteotrophic. Indomethacin which is a prostaglandin inhibitor however does not modify the ability of LH to stimulate luteinization and maturation of the oocyte. The author postulates on the origin and the identification of the luteolytic factor and gives schematic illustration of the arterio-venous blood supply between the uterus and the ovary which is so important for the good function of the prostaglandins. It is possible that PGF type prostaglandins which are vasoconstrictor may reduce the flow of blood around the ovary, perhaps even specifically to luteal tissue. He postulates that PGF2 alpha in its relationship to its receptors is necessary but insufficient to explain the full luteolytic effect. Turning to the semen he shows that the nature and concentration of prostaglandins in semen varies from one species to another. He thinks that there is a triple role for prostaglandins with semen, which is: a participation in the events of ejaculation, an effect on the female genital tract, and an effect on the mobility of spermatozoa. He speaks of the role of prostaglandins on the Fallopian tubes and believes that they do have an effect on determining the movement of the tubes but cannot explain exactly what. [less ▲]

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See detailProstaglandines et reproduction animale: données générales
Hanzen, Christian ULg; Drion, Pierre ULg

in Le grand livre des prostaglandines (2003)

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See detailProstaglandines, secretion d'insuline et diabete sucre.
Giugliano, D.; Torella, R.; Scheen, André ULg et al

in Diabète & Métabolisme (1988), 14(6), 721-7

The islets of Langerhans have the enzymatic equipment permitting the synthesis of the metabolites of arachidonic acid: cyclo-oxygenase and lipo-oxygenase. Numerous studies have shown that cyclo-oxygenase ... [more ▼]

The islets of Langerhans have the enzymatic equipment permitting the synthesis of the metabolites of arachidonic acid: cyclo-oxygenase and lipo-oxygenase. Numerous studies have shown that cyclo-oxygenase derivatives, mainly PGE2, reduce the insulin response to glucose whereas lipo-oxygenase derivatives, mainly 15-HPETE, stimulate insulin secretion. So, for instance, drugs that increase prostaglandins synthesis as colchicine or furosemide inhibit insulin secretion while non steroid anti-inflammator drugs, mainly salicylates, which inhibit cyclo-oxygenase, enhance the insulin response to various stimuli. In type-2 (non insulin-dependent) diabetes, an increased sensitivity to endogenous prostaglandins has been proposed as a possible cause for the insulin secretion defect which characterizes this disease. Play in favor of this hypothesis the fact that the administration of PGE inhibits the insulin response to arginine in type-2 diabetics but not in normal subject and the fact that the administration of salicylates could improve the insulin response to glucose in some of these patients. [less ▲]

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See detailProstatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation.
Cornet, Anne ULg; Hanon, Emmanuel; Reiter, Eric R et al

in Prostate (The) (2003), 56(3), 220-30

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen ... [more ▼]

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen withdrawal. The regulation of PARM-1 by androgens is limited to this organ. We have studied the effects of PARM-1 overexpression in malignant prostate cells. METHODS: The PARM-1 cDNA was introduced into the rat cancer cell line MAT LyLu along with a doxycycline-dependent regulator. RESULTS: Maximal expression of PARM-1 (fivefold induction) was achieved by incubating the cells with 2 microM doxycycline for 48 hr. A study investigating the effect of PARM-1 overexpression on the transcription of 588 genes has shown that the TLP1 gene (encoding rat telomerase protein component 1) was the most up-regulated (fourfold). In addition, a dose-dependent increase in telomerase activity was observed in cells overexpressing PARM-1. In vivo, the androgen-deprived prostate showed an increased TLP1 level and increased telomerase activity. CONCLUSIONS: Increased telomerase activity is often associated with the immortalisation of cancer cell lines, particularly prostatic ones. This could mean that PARM-1 is involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells. [less ▲]

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See detailProsthesis-patient mismatch after mitral valve replacement: Back to reality
Pibarot, P.; Magne, Julien ULg; Dumesnil, J. G.

in Journal of Thoracic and Cardiovascular Surgery (The) (2008), 135(2), 464-465

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See detailProsthesis-Patient Mismatch is an independent Predictor of Short-term Mortality Following Mitral Valve Replacement.
Magne, Julien ULg; Mathieu, P; Dumesnil, JG et al

Conference (2008)

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See detailProsthetic valve dysfunction
Pibarot, P; Dumesnil, JG; Magne, Julien ULg

in Wang, A; Bashore, T M (Eds.) Valvular Heart Disease. (2009)

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See detailProsthetic vascular infection complicated or not by aortoenteric fistula: comparison of treatment with and without cryopreserved allograft (homograft).
Lavigne, Jean-Paul ULg; Postal, Alain ULg; Kolh, Philippe ULg et al

in European Journal of Vascular and Endovascular Surgery (2003), 25(5), 416-23

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study ... [more ▼]

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study. MATERIAL AND METHODS: two asynchronous series of 44 [series I: 1980-1994; 8 patients with aortoenteric fistula (AEF)] and 22 (series II: 1994-1997; 4 patients with AEF) patients were treated for prosthesis infection. All patients had prosthesis excision. In series I, there were 4 in situ reparations, 26 extra-anatomic bypass, 13 excision only, and one death at laparotomy. In series II, in situ cryopreserved allografts were implanted in all patients. RESULTS: operative mortality was 16% in series I and 13.6% in series II. For AEF patients, mortality was 37% in series I and 50% in series II. Among hospital survivors, infection-related late mortality was 13.5% in series I and 5% in series II. For AEF patients, late mortality was 20% in series I and 50% in series II. Incidence of reoperations was 54% in series I and 10.5% in series II (p<0.01). Hospital stay was 47.2+/-26.4 days in series I and 16.6+/-11.5 days in series II (p<0.001). CONCLUSIONS: compared to conventional treatment, incidence of reoperations and length of hospital stay are significantly decreased after cryopreserved allograft implantation. However, closure of aortic stump and extra-anatomic bypass gives better results for patients with AEF. [less ▲]

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See detailProstitution liégeoise, on change de trottoir ?
Vanesse, Marc ULg; Bokhorst, Hermine; Verstappen, Sonia et al

Conference given outside the academic context (2011)

Café politique sur la prostitution liégeoise et le projet d'Eros Center à Liège, avec une porte-parole des travailleurs du sexe, un auteur, deux travailleuses sociales et une représentante féministe.

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See detailLa prostitution
Chichoyan, Daisy ULg

in Postal Memorialis (2008), P240

La contribution étudie les dispositions du chapitre VI du titre VII (titre consacré aux infractions contre l’ordre des familles et contre la moralité publique) du second livre du Code pénal.

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See detailProSup, référentiel des compétences des enseignants du supérieur
Poumay, Marianne ULg; Georges, François ULg

Cartographic material (2009)

La carte représente les compétences poursuivies dans le master complémentaire en pédagogie universitaire pour servir le développement de l'expertise d'encadrant dans le domaine de l'enseignement.

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See detailProsztaglandin kezelés hatása a sárgatestre, a plasma progeszteron koncentrációra és a graaf-féle tüszöre
Repasi, Attila; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Szenci, Ottó; Brydl, Endre; Jurkovich, Viktor (Eds.) Proceedings: 16.Magyar Buiatrikus Kongresszus - The effect of herd health of cattle, sheep and goat on the profitable production (1995)

The results of three different prostaglandin treatment protocols are summarized in our summary: In the first experiment the effects of different doses (0 mg, 25 mg vs 35 mg) of prostaglandin treatments ... [more ▼]

The results of three different prostaglandin treatment protocols are summarized in our summary: In the first experiment the effects of different doses (0 mg, 25 mg vs 35 mg) of prostaglandin treatments from the day of treatment (Day 0) were examined. The percentage changes relative to the corpus luteum area decreased, and the percentage changes relative to the largest follicle area increased faster, and even the oestrus started sonner in cocas treated with 35 mg PGF2a than in those treated with 25 mg PGF2a. However, these differences between groups were not statistically significant. At the same lime, the decrease in the percentage changes relative to the area of corpora lutea and to the concentrations of P4 was statistically significant in both groups. In the second experiment treatment of dairy cows with 2 luteolytic dosages of PGF2a or its synthetic analogue at an 8-h interval resulted in more cows (non-significantly) (18 vs. 21) being observed in oestrus within 5 d after treatment and having significantly higher conception rate (27,8% vs. 66,6%) than with 1 treatment. Further studies in progress should confirm the benefit of 2 prostaglandin treatments in a larger scale. At the same lime, the type and the number of prostaglandin treatments had no effect on the incidence of ovulations alter oestrus, the number of ovulations without oestrous signs, the number of cows without oestrus and ovulation, and the average lime from treatment to oestrus. In the third experiment the lime of ovulation was examined alter detected oestrus and A.I. (Day 0) in prostaglandin treated and non-treated dairy cows. Large variations in the area of the CL were detected in the prostaglandin treated and untreated cows. The areas of the largest follicles in treated cows were somewhat smaller during the experiment, than those in untreated cows however those differences between the groups and within the groups were not statistically significant. The area of the largest follicle in cows with no ovulation also did not differ significantly. Some of the cows (n=7) in treated and non-treated groups did not ovulate at all during the experiment. The mean area of the ovulatory follicle on the day before ovulation was somewhat greater but not significantly, if ovulation occurred later regarding to AI, The overall conception rate was > 50% in both groups, but when the cows ovulated too early or too late in relation to the lime of AI the conception rate was significantly louver, therefore determination of the optimal lime for AI is of great practical importance. If ovulation does not occur within two days alter AI second AI may be recommended. Further studies are needed to evaluate the benefit of the second AI [less ▲]

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See detailProsztaglandin kezelések hatasa az ovulacio bekövezkeztére szarvasmarhakban
Répasi, A; Beckers, Jean-François ULg; Sulon, J et al

in Proceeding of prosztaglandin kezelések hatasa az ovulacio bekövezkeztére szarvasmarhakban (2003, October)

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See detailThe protease genes CYLD and USP40 are associated with Crohn's disease: results from a European Consortium
Cleynen, I; Artieda, M; Szczyoiorska, M et al

in Gastroenterology (2011), 140(5), 269

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See detailProteases and antiproteases in adult respiratory distress syndrome
Deby-Dupont, G.; Lamy, Maurice ULg; Faymonville, Marie-Elisabeth ULg et al

in Acute Respiratory Failure Monograph Series: Lung Biology in Health and Disease (1989)

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See detailProtéases et inhibiteurs de protéases : implications multiples dans le développement et le vieillissement cérébral
Leprince, Pierre ULg; Rogister, Bernard ULg; Delrée, Paul et al

in Revue d'Oto-Neuro-Ophtalmologie (1991), 12(13), 30-38

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See detailLes protéases stromales dans la progression cancéreuse mammaire
Foidart, Jean-Michel ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1997), 152(5), 229-35235-7

Matrix metalloproteases represent a family of proteases secreted as latent inactive enzymes able to degrade the majority of extracellular matrix components. These enzymes are overexpressed during several ... [more ▼]

Matrix metalloproteases represent a family of proteases secreted as latent inactive enzymes able to degrade the majority of extracellular matrix components. These enzymes are overexpressed during several pathological tissue remodelings including tumor progression and tumor invasion. It was indeed classically admitted that matrix metalloproteases involved in tumoral progression were preferentially expressed by cancerous cells. Our studies on gelatinase A and stromelysin-3 have, however, demonstrated that their messenger RNAS are detected in fibroblasts of the peritumoral stroma in human mammary carcinoma and not in the cancerous cells themselves. By immunohistochemistry, we have detected gelatinase A in the cytoplasm of fibroblasts and at the surface of the tumor cells. This membrane localization of the protein could result from its binding, following secretion by the neighbouring stromal cells, to a specific binding site expressed at the surface of the carcinoma cells. These cells are indeed able to induce an increased proteolytic activity by enhancing the transcription of these enzymes by peritumoral fibroblasts. These enzymes represent therefore potential targets for the development of new therapeutic strategies. [less ▲]

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