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See detailProstaglandines, secretion d'insuline et diabete sucre.
Giugliano, D.; Torella, R.; Scheen, André ULg et al

in Diabète & Métabolisme (1988), 14(6), 721-7

The islets of Langerhans have the enzymatic equipment permitting the synthesis of the metabolites of arachidonic acid: cyclo-oxygenase and lipo-oxygenase. Numerous studies have shown that cyclo-oxygenase ... [more ▼]

The islets of Langerhans have the enzymatic equipment permitting the synthesis of the metabolites of arachidonic acid: cyclo-oxygenase and lipo-oxygenase. Numerous studies have shown that cyclo-oxygenase derivatives, mainly PGE2, reduce the insulin response to glucose whereas lipo-oxygenase derivatives, mainly 15-HPETE, stimulate insulin secretion. So, for instance, drugs that increase prostaglandins synthesis as colchicine or furosemide inhibit insulin secretion while non steroid anti-inflammator drugs, mainly salicylates, which inhibit cyclo-oxygenase, enhance the insulin response to various stimuli. In type-2 (non insulin-dependent) diabetes, an increased sensitivity to endogenous prostaglandins has been proposed as a possible cause for the insulin secretion defect which characterizes this disease. Play in favor of this hypothesis the fact that the administration of PGE inhibits the insulin response to arginine in type-2 diabetics but not in normal subject and the fact that the administration of salicylates could improve the insulin response to glucose in some of these patients. [less ▲]

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See detailProstatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation.
Cornet, Anne ULg; Hanon, Emmanuel; Reiter, Eric R et al

in Prostate (The) (2003), 56(3), 220-30

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen ... [more ▼]

BACKGROUND: Prostatic androgen-repressed message-1 (PARM-1) has been cloned from the prostate. The transcript of the PARM-1 gene is overexpressed during regression of the prostate after androgen withdrawal. The regulation of PARM-1 by androgens is limited to this organ. We have studied the effects of PARM-1 overexpression in malignant prostate cells. METHODS: The PARM-1 cDNA was introduced into the rat cancer cell line MAT LyLu along with a doxycycline-dependent regulator. RESULTS: Maximal expression of PARM-1 (fivefold induction) was achieved by incubating the cells with 2 microM doxycycline for 48 hr. A study investigating the effect of PARM-1 overexpression on the transcription of 588 genes has shown that the TLP1 gene (encoding rat telomerase protein component 1) was the most up-regulated (fourfold). In addition, a dose-dependent increase in telomerase activity was observed in cells overexpressing PARM-1. In vivo, the androgen-deprived prostate showed an increased TLP1 level and increased telomerase activity. CONCLUSIONS: Increased telomerase activity is often associated with the immortalisation of cancer cell lines, particularly prostatic ones. This could mean that PARM-1 is involved, via increased telomerase activity, in a survival program enabling certain prostatic cells to resist apoptosis, thus conferring a selective advantage to pre-cancerous or cancerous cells. [less ▲]

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See detailProsthesis-patient mismatch after mitral valve replacement: Back to reality
Pibarot, P.; Magne, Julien ULg; Dumesnil, J. G.

in Journal of Thoracic and Cardiovascular Surgery (The) (2008), 135(2), 464-465

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See detailProsthesis-Patient Mismatch is an independent Predictor of Short-term Mortality Following Mitral Valve Replacement.
Magne, Julien ULg; Mathieu, P; Dumesnil, JG et al

Conference (2008)

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See detailProsthetic valve dysfunction
Pibarot, P; Dumesnil, JG; Magne, Julien ULg

in Wang, A; Bashore, T M (Eds.) Valvular Heart Disease. (2009)

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See detailProsthetic vascular infection complicated or not by aortoenteric fistula: comparison of treatment with and without cryopreserved allograft (homograft).
Lavigne, Jean-Paul ULg; Postal, Alain ULg; Kolh, Philippe ULg et al

in European Journal of Vascular and Endovascular Surgery (2003), 25(5), 416-23

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study ... [more ▼]

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study. MATERIAL AND METHODS: two asynchronous series of 44 [series I: 1980-1994; 8 patients with aortoenteric fistula (AEF)] and 22 (series II: 1994-1997; 4 patients with AEF) patients were treated for prosthesis infection. All patients had prosthesis excision. In series I, there were 4 in situ reparations, 26 extra-anatomic bypass, 13 excision only, and one death at laparotomy. In series II, in situ cryopreserved allografts were implanted in all patients. RESULTS: operative mortality was 16% in series I and 13.6% in series II. For AEF patients, mortality was 37% in series I and 50% in series II. Among hospital survivors, infection-related late mortality was 13.5% in series I and 5% in series II. For AEF patients, late mortality was 20% in series I and 50% in series II. Incidence of reoperations was 54% in series I and 10.5% in series II (p<0.01). Hospital stay was 47.2+/-26.4 days in series I and 16.6+/-11.5 days in series II (p<0.001). CONCLUSIONS: compared to conventional treatment, incidence of reoperations and length of hospital stay are significantly decreased after cryopreserved allograft implantation. However, closure of aortic stump and extra-anatomic bypass gives better results for patients with AEF. [less ▲]

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See detailProstitution liégeoise, on change de trottoir ?
Vanesse, Marc ULg; Bokhorst, Hermine; Verstappen, Sonia et al

Conference given outside the academic context (2011)

Café politique sur la prostitution liégeoise et le projet d'Eros Center à Liège, avec une porte-parole des travailleurs du sexe, un auteur, deux travailleuses sociales et une représentante féministe.

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See detailLa prostitution
Chichoyan, Daisy ULg

in Postal Memorialis (2008), P240

La contribution étudie les dispositions du chapitre VI du titre VII (titre consacré aux infractions contre l’ordre des familles et contre la moralité publique) du second livre du Code pénal.

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See detailProSup, référentiel des compétences des enseignants du supérieur
Poumay, Marianne ULg; Georges, François ULg

Cartographic material (2009)

La carte représente les compétences poursuivies dans le master complémentaire en pédagogie universitaire pour servir le développement de l'expertise d'encadrant dans le domaine de l'enseignement.

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See detailProsztaglandin kezelés hatása a sárgatestre, a plasma progeszteron koncentrációra és a graaf-féle tüszöre
Repasi, Attila; Beckers, Jean-François ULg; Sulon, Joseph ULg et al

in Szenci, Ottó; Brydl, Endre; Jurkovich, Viktor (Eds.) Proceedings: 16.Magyar Buiatrikus Kongresszus - The effect of herd health of cattle, sheep and goat on the profitable production (1995)

The results of three different prostaglandin treatment protocols are summarized in our summary: In the first experiment the effects of different doses (0 mg, 25 mg vs 35 mg) of prostaglandin treatments ... [more ▼]

The results of three different prostaglandin treatment protocols are summarized in our summary: In the first experiment the effects of different doses (0 mg, 25 mg vs 35 mg) of prostaglandin treatments from the day of treatment (Day 0) were examined. The percentage changes relative to the corpus luteum area decreased, and the percentage changes relative to the largest follicle area increased faster, and even the oestrus started sonner in cocas treated with 35 mg PGF2a than in those treated with 25 mg PGF2a. However, these differences between groups were not statistically significant. At the same lime, the decrease in the percentage changes relative to the area of corpora lutea and to the concentrations of P4 was statistically significant in both groups. In the second experiment treatment of dairy cows with 2 luteolytic dosages of PGF2a or its synthetic analogue at an 8-h interval resulted in more cows (non-significantly) (18 vs. 21) being observed in oestrus within 5 d after treatment and having significantly higher conception rate (27,8% vs. 66,6%) than with 1 treatment. Further studies in progress should confirm the benefit of 2 prostaglandin treatments in a larger scale. At the same lime, the type and the number of prostaglandin treatments had no effect on the incidence of ovulations alter oestrus, the number of ovulations without oestrous signs, the number of cows without oestrus and ovulation, and the average lime from treatment to oestrus. In the third experiment the lime of ovulation was examined alter detected oestrus and A.I. (Day 0) in prostaglandin treated and non-treated dairy cows. Large variations in the area of the CL were detected in the prostaglandin treated and untreated cows. The areas of the largest follicles in treated cows were somewhat smaller during the experiment, than those in untreated cows however those differences between the groups and within the groups were not statistically significant. The area of the largest follicle in cows with no ovulation also did not differ significantly. Some of the cows (n=7) in treated and non-treated groups did not ovulate at all during the experiment. The mean area of the ovulatory follicle on the day before ovulation was somewhat greater but not significantly, if ovulation occurred later regarding to AI, The overall conception rate was > 50% in both groups, but when the cows ovulated too early or too late in relation to the lime of AI the conception rate was significantly louver, therefore determination of the optimal lime for AI is of great practical importance. If ovulation does not occur within two days alter AI second AI may be recommended. Further studies are needed to evaluate the benefit of the second AI [less ▲]

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See detailProsztaglandin kezelések hatasa az ovulacio bekövezkeztére szarvasmarhakban
Répasi, A; Beckers, Jean-François ULg; Sulon, J et al

in Proceeding of prosztaglandin kezelések hatasa az ovulacio bekövezkeztére szarvasmarhakban (2003, October)

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See detailThe protease genes CYLD and USP40 are associated with Crohn's disease: results from a European Consortium
Cleynen, I; Artieda, M; Szczyoiorska, M et al

in Gastroenterology (2011), 140(5), 269

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See detailProteases and antiproteases in adult respiratory distress syndrome
Deby-Dupont, G.; Lamy, Maurice ULg; Faymonville, Marie-Elisabeth ULg et al

in Acute Respiratory Failure Monograph Series: Lung Biology in Health and Disease (1989)

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See detailProtéases et inhibiteurs de protéases : implications multiples dans le développement et le vieillissement cérébral
Leprince, Pierre ULg; Rogister, Bernard ULg; Delrée, Paul et al

in Revue d'Oto-Neuro-Ophtalmologie (1991), 12(13), 30-38

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See detailLes protéases stromales dans la progression cancéreuse mammaire
Foidart, Jean-Michel ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1997), 152(5), 229-35235-7

Matrix metalloproteases represent a family of proteases secreted as latent inactive enzymes able to degrade the majority of extracellular matrix components. These enzymes are overexpressed during several ... [more ▼]

Matrix metalloproteases represent a family of proteases secreted as latent inactive enzymes able to degrade the majority of extracellular matrix components. These enzymes are overexpressed during several pathological tissue remodelings including tumor progression and tumor invasion. It was indeed classically admitted that matrix metalloproteases involved in tumoral progression were preferentially expressed by cancerous cells. Our studies on gelatinase A and stromelysin-3 have, however, demonstrated that their messenger RNAS are detected in fibroblasts of the peritumoral stroma in human mammary carcinoma and not in the cancerous cells themselves. By immunohistochemistry, we have detected gelatinase A in the cytoplasm of fibroblasts and at the surface of the tumor cells. This membrane localization of the protein could result from its binding, following secretion by the neighbouring stromal cells, to a specific binding site expressed at the surface of the carcinoma cells. These cells are indeed able to induce an increased proteolytic activity by enhancing the transcription of these enzymes by peritumoral fibroblasts. These enzymes represent therefore potential targets for the development of new therapeutic strategies. [less ▲]

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See detailProteases, extracellular matrix and cancer: a workshop of the path B study section
Declerck, Y. A.; Mercurio, A. M.; Stack, M. S. et al

in American Journal of Pathology (2004), 164(4), 1131-39

The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that ... [more ▼]

The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and activity of many growth factors, growth factor receptors, and cytokines are modified. ECM-degrading proteases also play a critical role in angiogenesis, where they can act as positive as well as negative regulators of endothelial cell proliferation and vascular morphogenesis. This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002. [less ▲]

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See detailPROTECCIÓN JURÍDICA DEL PATRIMONIO CULTURAL COLOMBIANO. EL PLURALISMO PRINCIPIO ORIENTADOR DE UNA CULTURA DE PAZ
Marquez Guerra, José Francisco ULg

Master's dissertation (2003)

Este trabajo intenta desde una de las múltiples formas posibles abordar el estudio del patrimonio cultural. El primero de sus propósitos es presentar un análisis jurídico sobre el desarrollo evolutivo del ... [more ▼]

Este trabajo intenta desde una de las múltiples formas posibles abordar el estudio del patrimonio cultural. El primero de sus propósitos es presentar un análisis jurídico sobre el desarrollo evolutivo del concepto, su significado, los bienes y valores que comprende y su funcionalidad como crisol de identidades, dentro del marco normativo de la jurisdicción colombiana y el correspondiente régimen que somete el acervo cultural de la nación. El segundo propósito es plantear el pluralismo como principio fundamental que orienta y describe la acción del Estado Social de Derecho hacia el reconocimiento efectivo de las diversidades que conforman el pueblo colombiano. Se intenta demostrar, que la integración nacional sólo se logra cimentando la identidad cultural sobre el diálogo intercultural y la disposición abierta a la interacción con otras culturas dentro y más allá del ámbito Estatal. [less ▲]

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See detailProtecting Assets Under Non-Parametric Market Conditions
Choffray, Jean-Marie ULg; Pahud de Mortanges, Charles ULg

E-print/Working paper (2014)

Under non-parametric market conditions, investors usually become more concerned about the return of their money than about the return on their money. Protecting assets becomes the surest if not the only ... [more ▼]

Under non-parametric market conditions, investors usually become more concerned about the return of their money than about the return on their money. Protecting assets becomes the surest if not the only path to survival and growth. High frequency trading systems, over leveraged shadow entities, flash crashes, and stealth central bank actions, to name a few, contribute to create a “Rumsfeldian” type of world in which decision makers have to cope not only with “Known knowns” – things they know that they know – but also with “Unknown unknowns” – things they don’t know that they don’t know! The goal of this paper is to explore such a conceptual model of the “Unknown” and to derive from it a concise and coherent set of battle-tested heuristics aimed at designing effective investment strategies to protect assets. [less ▲]

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See detailProtecting men and women from fracture
Reginster, Jean-Yves ULg

in Osteoporosis International (2011, March), 22(Suppl.1), 413-414

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See detailProtection against abortion linked to gamma interferon production in pregnant dairy cows naturally infected with Neospora caninum
Lopez-Gatius, F.; Almeria, S.; Donofrio, G. et al

in Theriogenology (2007), 68(7), 1067-1073

Many immunological aspects of pregnancy, such as the role played by gamma interferon (IFN-gamma) in abortion, are not well understood. Neospora caninum is an intracellular protozoan considered to be among ... [more ▼]

Many immunological aspects of pregnancy, such as the role played by gamma interferon (IFN-gamma) in abortion, are not well understood. Neospora caninum is an intracellular protozoan considered to be among the main causes of abortion in cattle worldwide. The present study analyzes the interaction between IFN-gamma production and N. caninum infection in naturally infected pregnant cows. Data were obtained from 126 pregnant cows: 86 seropositive and 40 seronegative for the parasite. Pregnancy diagnosis and blood sample collection were performed on days 40, 90, 120, 150, 180 and 210 post-insemination or until the time of abortion detection. Plasma was tested for antibodies against N. caninum and IFN-gamma. Interferon-garmna was detected at some point along the pregnancy in 16 (19%) of the 86 Neospora-seropositive cows yet was undetectable in the 40 seronegative animals. Of the 126 pregnancies examined, 22 (17.5%) ended in abortion. Abortion occurred in 24.4% of seropositive cows (21/86) and in 2.5% of seronegative animals (1/40). Significant (P < 0.0001) interaction was observed between Neospora-seropositivity and IFN-gamma production. Based on the odds ratio, the risk of abortion was 15.6 times higher in seropositive cows not producing IFN-gamma than in seronegative animals, whereas neosporosis had no effect in seropositive cows with IFN-gamma production. A significant (P = 0.001) negative effect of IFN-gamma production on the Neospora titer was furthermore observed in the 65 non-aborting seropositive animals. These results indicate that IFN-gamma production affords protection against abortion in Neospora-infected cows and also point to a reduced humoral immune response to N. caninum during gestation in cows producing IFN-gamma. [less ▲]

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