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See detailMultilocus-based phylogeny and species recognition within the cosmopolitan Peltigera neopolydactyla-dolichorhiza complex
Magain, Nicolas ULg; Miadlikowska, Jolanta; Lutzoni, François et al

Poster (2012, January)

The Peltigera neopolydactyla/dolichorhiza complex is broadly distributed, growing in boreal and temperate regions from northern Norway to southern Chile, as well as in tropical mountains. Observed ... [more ▼]

The Peltigera neopolydactyla/dolichorhiza complex is broadly distributed, growing in boreal and temperate regions from northern Norway to southern Chile, as well as in tropical mountains. Observed morphotype and chemotype variation within this complex suggested the presence of multiple undescribed species. We inferred the phylogeny of Peltigera section Polydactylon with a special focus on the Peltigera neopolydactyla/dolichorhiza complex to determine the full breadth of this species complex, and to assess if taxa from different parts of the worlds but with similar morphological features share a most recent common ancestor. About 525 ITS sequences representing 104 distinct haplotypes were generated for representatives of Peltigera section Polydactylon. We selected a representative of each broadly defined phylotype for which three protein-coding loci: RPB1.1, b-tubulin and EFT2.1 were sequenced. Each of the three protein coding loci provided equivalent or more resolution and support than the ITS locus. The greatest proportion of significantly supported nodes across the tree resulted from β-tubulin alone. Many specimens identified as P. neopolydactyla and P. dolichorhiza are placed outside of this species complex. As currently defined both species represent polyphyletic assemblages of taxa including several potentially undescribed species. Our phylogenies suggest the presence of putatively new species within several complexes across the section. [less ▲]

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See detailMultimarker approach to risk stratification
Chapelle, Jean-Paul ULg

in Clinical Chemistry & Laboratory Medicine (2003), 41

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See detailMultimarker approach to risk stratification
Chapelle, Jean-Paul ULg

Conference (2003, October)

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See detailMultimedia education in headache: the European Neurological Network.
Russell, M. B.; Dremstrup Nielsen, K.; Rasmussen, C. et al

in European Journal of Neurology (2000), 7(3), 355-62

The European Neurological Network is a European Economic Community supported project. The purpose of the project was to develop a multimedia educational tool for general practitioners in order to improve ... [more ▼]

The European Neurological Network is a European Economic Community supported project. The purpose of the project was to develop a multimedia educational tool for general practitioners in order to improve their management of sleep disorders, epilepsy and headache. The project involves approximately one hundred engineers and physicians from Belgium, Denmark, England, Finland, France, Germany, Italy, Portugal and Spain. This paper concerns the multimedia educational tool on headache. The system consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and nomenclature. It is possible to move between the modules both vertically and horizontally. The headache classification of the International Headache Society is provided in full text as a work of reference. This classification is used world wide and has been adopted by International Classification of Diseases 10 Neurological Adaptation (ICD-10 NA) and the World Health Organisation. The clinical data concentrate on migraine and tension-type headache, the two most common headache disorders, but data on familial hemiplegic migraine, cluster headache, drug-induced headache and secondary headaches are also available. The headache tutorial consists of case records that the user can test their diagnostic abilities on. The diagnostic headache diary is an expert system on headache diagnostics. It can be filled in during a consultation in order to provide the headache diagnosis or it can be printed and used by the headache patient to record headache attacks and medicine consumption. The nomenclature module provides an explanation of words and expressions used in the system. [less ▲]

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See detailLe multimédia et l'apprentissage
Denis, Brigitte ULg

Conference given outside the academic context (1996)

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See detailMultimedia in the E-LOTOS Process Algebra
Leduc, Guy ULg

in Formal Methods for Distributed Processing - A Survey of Object Oriented Approaches (2001)

We illustrate how the ISO E-LOTOS language can be used to describe an ODP multicast multimedia binding object of some complexity. The timing features of the language are briefly recalled, and play a major ... [more ▼]

We illustrate how the ISO E-LOTOS language can be used to describe an ODP multicast multimedia binding object of some complexity. The timing features of the language are briefly recalled, and play a major role in the description of the example, but many other features of E-LOTOS are also very useful to obtain a more modular and more readable specification. Users familiar with LOTOS will also learn how some E-LOTOS features can advantageously replace the traditional LOTOS ones. [less ▲]

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See detailMultimedia-enhanced learning productions - A typology based on instructional use and needed resources
Van de Poël, Jean-François ULg; Martin, Pierre; Verpoorten, Dominique ULg

Poster (2015, November 24)

This poster introduces a typology of educational multimedia objects stemming from an analysis of 400 audiovisual items produced by IFRES-eCampus, the staff development unit of the University of Liège ... [more ▼]

This poster introduces a typology of educational multimedia objects stemming from an analysis of 400 audiovisual items produced by IFRES-eCampus, the staff development unit of the University of Liège (Belgium). The classification of the multimedia productions is based on their instructional use and is enriched by additional qualifications in terms of time investment by the faculty and the Teaching and Learning center. [less ▲]

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See detailMultimodal analgesia in dentistry
Chavarria Bolanos, Daniel ULg

Conference (2013, July 04)

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See detailMultimodal collaborative activity among architectural designers using an augmented desktop at distance or in collocation
Burkhardt, J.-M.; Détienne, F.; Moutsingua-Mpaga, L. et al

in Abascal, J.; Fajardo, I.; Oakley, I. (Eds.) Proceedings of ECCE'08, the 15th European conference on Cognitive ergonomics: the ergonomics of cool interaction (2008, September)

Motivation – To analyse how Augmented Reality associated to video may affect collaborative design and multimodal interactions. Research approach – An exploratory study that aims to compare 2 pairs of last ... [more ▼]

Motivation – To analyse how Augmented Reality associated to video may affect collaborative design and multimodal interactions. Research approach – An exploratory study that aims to compare 2 pairs of last year students in co-presence with 1 distant pair. Each pair had to solve an architectural design problem. Collected video has been coded with a systematic method of protocol analysis. Findings/Design – When using an AR desktop-based CAD, distance may not affect the design process itself whereas it may affect how the process is distributed across the various modalities of collaboration. Furthermore, collaborating and architectural experiences influence collaboration and/or design. Research limitations/Implications – Only 3 pairs of students participated in the study resulting in 12 h of video protocol, which limits generalisation of the findings. Originality/Value – The research makes a contribution in providing a detailed view on how external (e.g. situation, technology) and individual factors may affect the activity of collaborative design. Furthermore, we propose a coding method usable beyond design in a wide range of collaborative activities to underline how they are affected by technology and other situational constraints. Take away message – Technology constraints as well as personnal characteristics of designers result in designing with specific forms of multimodal collaboration. [less ▲]

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See detailMultimodal evaluation of gait and stride dynamics in relapsing and progressive forms of multiple sclerosis
Belachew, Shibeshih ULg; Pierard, Sébastien ULg; PHAN BA, Remy ULg et al

in Proceedings of the Belgian Royal Academies of Medicine (2012), 1

Ambulation measures are being increasingly recognized as highly relevant to the quantification of multiple sclerosis (MS) severity and response to treatment. Feet paths are highly informative for gait ... [more ▼]

Ambulation measures are being increasingly recognized as highly relevant to the quantification of multiple sclerosis (MS) severity and response to treatment. Feet paths are highly informative for gait analysis and we have recently designed a new system, which captures the position of the feet in real time. We use several range laser scanners (RLS) to analyze a horizontal slice of the scene in which each foot is considered as a point, and the vertical movements are ignored. Neat ambulation measures may be easily extracted such as walking speed, distance between feet over time, swing phase duration, and gait asymmetry in specific settings of walking recommendations. Our RLS platform is much cheaper than existing sensor-based and motion capture systems and may be more convenient for the development of multicentric clinical trials settings since patients can be easily and rapidly assessed without tags or sensors in the hallway of an outpatient clinic. We use 4 BEA LZR-i100 RLS arranged in a corridor of at least 10m long and 4m width, devoid of obstacle. The scanned plane is chosen to be located at 15 cm above the floor, which is right above the tibio-tarsal joint of the ankle in a barefoot configuration for adult individuals in stance phase. We expect further studies to validate and empower the meaning of non-intrusive RLS-derived gait measures that should pave the ground for major improvements in the way we will assess the efficacy of disease-modifying treatments (DMTs), physical therapy and symptomatic interventions on walking impairment, ataxia and fatigability in MS. RLS-derived gait measures may also reveal to be crucial in the near future for the development of treatments that would specifically target progressive forms of MS. [less ▲]

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See detailMultimodal evidence of a rostro-caudal and ventro-dorsal organization in the dorsal premotor cortex
Genon, Sarah ULg; Li, Hai; Fan, Lingzhong et al

Poster (2016)

Introduction Different methods for in-vivo characterization have resulted in different maps of the human dorsal premotor cortex (PMd): Task-based functional studies suggested a rostro-caudal gradient ... [more ▼]

Introduction Different methods for in-vivo characterization have resulted in different maps of the human dorsal premotor cortex (PMd): Task-based functional studies suggested a rostro-caudal gradient corresponding to a cognitive-motor gradient1,2 and mapping based on resting-state functional connectivity (RSFC) likewise suggested a subdivision along the rostro-caudal axis3. In contrast, mapping based on structural connectivity as assessed by probabilistic diffusion tractography (PDT) provided evidence that the dorsal part of the precentral gyrus (PG) is organized along a ventro-dorsal axis4. However, there is currently no multimodal mapping of a broadly defined PMd. The present study used a multimodal approach to (1) identify a robust topographical organization of the right PMd by using connectivity-based parcellation (CBP) applied to a meta-analytic approach of task-related coactivation data (i.e. meta-analytic connectivity modeling, MACM5,6), and (2) examine whether the thus obtained parcellation pattern would be reproduced by CBP based on two other connectivity modalities: unconstrained functional (as reflected by RSFC) and structural as measured by PDT based on diffusion-weighted imaging (DWI). Methods A volume of interest (VOI) was defined by merging PMd activation sites from several meta-analyses serving as robust functional localizers of the PMd while excluding primary sensorimotor areas. MACM-CBP6 was performed using Brainmap database. RSFC-CBP and PDT-CBP were performed on distinct datasets to ensure independent parcellation7. RSFC-CBP was computed on RS data of 124 healthy subjects (age: 39.5 ± 11.5 yrs., 66 males) from the 1000BRAINS project8. The voxels’ time series (TS) were first cleaned from confounding effects using PCA denoising and global signal regression. RSFC was then computed by Pearson correlations between the TS of the VOI voxels and those of the rest of the brain. PDT-CBP9 was performed on DWI data of 20 healthy subjects (age: 18.5 ± .76, 10 males) using FSL. Several cluster solutions (k solution) were examined with k-means for MACM- and RSFC-CBP and spectral clustering for PDT-CBP. The choice of the k solution was driven by task-based functional data (MACM) based on three criteria: variation of information, percentage of deviants, and silhouette value6. Results The selected criteria jointly identified the 5-cluster (5k) solution as optimal across the range of functional studies from Brainmap database (Figure 1). Examination of stability across subjects following PDT-CBP further suggested that k=5 may be considered a local optimum within 2 ≤ k ≤ 6. This solution revealed a similar pattern of topographical organization across modalities (Figure 2) with a subdivision along both rostro-caudal and ventro-dorsal axes, including a rostral cluster lying mainly anteriorly to the PG, a central one at the intersection of the precentral sulcus and the superior frontal gyrus, a caudal one in the posterior part of the PG, a ventral one adjacent to ventral PM, and a dorsal one adjacent to the inter-hemispheric premotor areas. Discussion For the first time our study revealed that the PMd could be divided along two axes: rostro-caudal and ventro-dorsal. This is consistent with previous functional2 and microstructure studies10 in humans and non-human primates suggesting a rostro-caudal distinction and with a previous PDT-CBP of the (dorsal) precentral gyrus4 showing that it could be subdivided in the ventro-dorsal direction. Importantly, this topographical organization was found in the independent analysis of three different connectivity aspects: task functional, unconstrained functional and structural, each based on different datasets. In sum, different modalities consistently show that the PMd can be subdivided into 5 subregions organized along both rostro-caudal and ventro-dorsal axes, comprehensively integrating patterns previously revealed by different methods. [less ▲]

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See detailMultimodal evoked potentials for functional quantification and prognosis in multiple sclerosis
GIFFROY, Xavier ULg

in BMC Neurology (2016)

Functional biomarkers able to identify multiple sclerosis (MS) patients at high risk of fast disability progression are lacking. The aim of this study was to evaluate the ability of multimodal (upper and ... [more ▼]

Functional biomarkers able to identify multiple sclerosis (MS) patients at high risk of fast disability progression are lacking. The aim of this study was to evaluate the ability of multimodal (upper and lower limbs motor, visual, lower limbs somatosensory) evoked potentials (EP) to monitor disease course and identify patients exposed to unfavourable evolution. One hundred MS patients were assessed with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) at baseline (T0) and about 6 years later (T1). The Spearman correlation (rS) was used to evaluate the relationship between conventional EP scores and clinical findings. Multiple (logistic) regression analysis estimated the predictive value of baseline electrophysiological data for three clinical outcomes: EDSS, annual EDSS progression, and the risk of EDSS worsening. In contrast to longitudinal correlations, cross-sectional correlations between the different EP scores and EDSS were all significant (0.33 ≤ rS < 0.67, p < 0.001). Baseline global EP score and EDSS were highly significant predictors (p < 0.0001) of EDSS progression 6 years later. The aseline global EP score was found to be an independent predictor of the EDSS annual progression rate (p < 0.001), and of the risk of disability progression over time (p < 0.005). Based on a ROC curve determination, we defined a Global EP Score cut off point (17/30) to identify patients at high risk of disability progression illustrated by a positive predictive value of 70 %. This study provides a proof of the concept that electrophysiology could be added to MRI and used as another complementary prognostic tool in MS patients. [less ▲]

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See detailMultimodal modelling of the human brain
Ziegler, Erik ULg

Doctoral thesis (2014)

There are many ways to model properties of the brain from magnetic resonance imaging (MRI) data. One acquisition technique, known as diffusion-weighted imaging (DWI), can map the speed and direction of ... [more ▼]

There are many ways to model properties of the brain from magnetic resonance imaging (MRI) data. One acquisition technique, known as diffusion-weighted imaging (DWI), can map the speed and direction of water diffusion within the brain. This work explores the quantitative potential of DWI, in combination with other neuroimaging modalities, for in vivo modelling of the human brain. Fiber tractography from DWI can be used to construct a wiring diagram of the brain (or connectome) and identify connectivity patterns between regions. To explore the utility of connectome modelling, we constructed brain networks from healthy subjects carrying known genetic variations. Using machine learning, we demonstrated high classification accuracy between subjects with different genotypes using only their connectomes. Next, we tested whether fiber track density images could be used to de- tect early pathological effects in patients with Parkinson’s disease. We found increases in track density in disease-relevant regions of the white matter, including the nigrostriatal pathway, used unbiased whole-brain statistical testing. This result is extremely encouraging, as axonal degen- eration within this area is challenging to identify with standard magnetic resonance imaging contrasts. Finally, a finite element modelling (FEM) approach was developed for solving the electroencephalography (EEG) forward problem. Electrical conductivity tensors were estimated from DWI in order to represent the heterogeneous conductivity profile of the white matter. When tested against the analytical solution, this FEM method proved more reliable than the current state-of-the-art alternative. Advanced brain modelling from DWI can clearly provide lucrative results. These methods have been open-sourced for use by the community. [less ▲]

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See detailMultimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy".
Bruno, Marie-Aurélie ULg; Fernandez-Espejo, D.; Lehembre, Remy ULg et al

in Progress in Brain Research (2011), 193

Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information ... [more ▼]

Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness. [less ▲]

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See detailMultimodality blood conservation strategy in cardiac surgery with cardiopulmonary bypass: the CHU of Liege experience
ERPICUM, Marie ULg; BLAFFART, Francine ULg; DEFRAIGNE, Jean ULg et al

Poster (2012, November 20)

This study presents the transfusion rates of cardiac surgery patients and describes the in-house strategy of blood conservation applied in a single centre

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See detailMultimodality blood conservation strategy in cardiac surgery with cardiopulmonary bypass : the CHU of Liège experience
ERPICUM, Marie ULg; BLAFFART, Francine ULg; DEFRAIGNE, Jean ULg et al

Poster (2012, September 29)

Introduction: The aim of this study is to analyze the transfusion rates of cardiac surgery patients in a single centre following an in-house strategy of blood conservation. Methods: The data of all adult ... [more ▼]

Introduction: The aim of this study is to analyze the transfusion rates of cardiac surgery patients in a single centre following an in-house strategy of blood conservation. Methods: The data of all adult patients undergoing normothermic cardiac surgery with cardiopulmonary bypass (CPB) over a 1 year period were retrospectively collected (n=491). Management protocols were described. The transfusion rates of allogeneic blood components were recorded: red blood cells (RBC), fresh frozen plasma (FFP) and platelets (PT), as well as the number of units transfused. The timing of transfusion was categorized: during CPB (peroperative period), within the first 48 postoperative hours after wean out CPB (early postoperative period) and during the hospitalisation from surgery until discharge (hospitalisation). The hematocrit values were recorded during CPB, 10 minutes after wean out CPB, after the first 48 postoperative hours and at discharge from hospital. Results: Two hundred and forty-eight patients (50%) received an allogeneic blood component transfusion during hospitalisation. One hundred and twenty-one patients (25%) received RBC during the operative period; the median of units transfused was 2(1-2).The lowest hematocrit value during CPB was 21(19-24) % in median. A cell salvage device was used in each case: the median volume of washed red blood cells transfused was 678(512-891) mL. The median hematocrit value after CPB was 23(21-25) %. One hundred and sixty-five patients (34%) were transfused in the early postoperative period: 27% received RBC, 18% received FFP and 18% received PT. The median of units transfused was 2(1-3) for RBC, 4(2-6) for FFP and 1(1-2) for PT. The median hematocrit value after 48 hours was 32(29-34) % and 32(30-35) % at discharge. Conclusion: The transfusion rates observed in this series are relatively high compared with the literature. Improvements will be made in our practice and protocols management in order to decrease the need of transfusion. This detailed audit of the transfusion practices in our cardiac surgery centre would be helpful to value the effectiveness of further improvements. [less ▲]

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See detailMultimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model
NCHIMI LONGANG, Alain ULg; Courtois, Audrey ULg; EL HACHEMI, Mounia ULg et al

in European Radiology (2015), online

Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction ... [more ▼]

Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence. Methods The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates. Results All of the following significantly increased with time post-induction (p < 0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion. Conclusion Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in both MRI and FDG PET, relating to its biological activities. [less ▲]

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See detailMultimodality staging of lung cancer
THULKAR; NAMUR, Gauthier ULg; HUSTINX, Roland ULg et al

in PET Clinics (2011), 6

Lung cancer is among the most common and lethal cancers around the world. Most lung cancers are directly attributed to smoking. Common histologic subtypes of lung carcinomas are squamous cell carcinoma ... [more ▼]

Lung cancer is among the most common and lethal cancers around the world. Most lung cancers are directly attributed to smoking. Common histologic subtypes of lung carcinomas are squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. These carcinomas have similar presentations and are primarily treated surgically. Hence, these are usually classified as non-small cell lung carcinoma. Small cell lung carcinoma is an aggressive neuroendocrine tumor with a generally poor prognosis. It usually presents with massive mediastinal lymphadenopathy and widespread metastases at initial diagnosis, and is usually treated with chemotherapy and radiotherapy; surgery has little role.Cough, dyspnea and hemoptysis are the consistent clinical features of most lung cancers. Advances tumors with pleural, chest wall, or mediastinal invasion produce a variety of additional clinical features such as chest pain, brachial plexus neuropathy, Horner syndrome, phrenic or recurrent laryngeal nerve palsy, dysphagia, or superior vena cava syndrome. Sone of the lung cancers are detected as small pulmonary nodules in asymptomatic individuals. [less ▲]

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