Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailPropofol Protects Cultured Rat Hippocampal Neurons against N-Methyl-D-Aspartate Receptor-Mediated Glutamate Toxicity
Hans, Pol ULg; Bonhomme, Vincent ULg; Collette, Julien ULg et al

in Journal of Neurosurgical Anesthesiology (1994), 6(4), 249-53

The effect of propofol on the toxicity induced by glutamate (GLU), N-methyl-D-aspartate (NMDA), kainate (KA), and amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) was investigated on cultured ... [more ▼]

The effect of propofol on the toxicity induced by glutamate (GLU), N-methyl-D-aspartate (NMDA), kainate (KA), and amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) was investigated on cultured fetal rat hippocampal neurons. The degree of neuronal injury was quantified by measuring the release of the neuron-specific enolase (NSE) into the culture media. The toxicity induced by brief exposure to GLU (10(-4) M) or to NMDA (10(-4) M) was significantly reduced by propofol, whereas that elicited by KA, AMPA (10(-4) M), or long GLU exposure was unaffected. In conclusion, high concentrations of propofol significantly attenuate NMDA receptor-mediated glutamate neurotoxicity in vitro. Further studies are needed to confirm this beneficial effect in vivo and to evaluate propofol as a neuroprotective anesthetic agent in pathologies involving glutamate release and NMDA-mediated toxicity. [less ▲]

Detailed reference viewed: 10 (0 ULg)
See detailPropofol reacts with peroxynitrite to form phenoxyl radicals. Demonstration by ESR
Mouithys-Mickalad, Ange ULg; Hans, P.; Deby-Dupont, G. et al

Conference (1998)

Detailed reference viewed: 5 (2 ULg)
Peer Reviewed
See detailPropofol reacts with peroxynitrite to form phenoxyl radicals. Demonstration by ESR
Mouithys-Mickalad, Ange ULg; Hans, Pol ULg; Deby-Dupont, Ginette et al

in Biochemical and Biophysical Research Communications (1998), 249(3), 833-837

Peroxynitrite (ONOO-), resulting from the reaction of nitric oxide with superoxide anion, is a powerful oxidant produced in activated macrophages, during ischemia-reperfusion processes as well as in ... [more ▼]

Peroxynitrite (ONOO-), resulting from the reaction of nitric oxide with superoxide anion, is a powerful oxidant produced in activated macrophages, during ischemia-reperfusion processes as well as in neurodegenerative disorders. This study investigated the reaction of the anesthetic agent propofol (PPF) with ONOO-, using electron spin resonance (ESR) and UV-visible spectrometry. Peroxynitrite was synthetized either from acidified hydrogen peroxide and nitrite, or from sodium azide and ozone. The addition of ONOO- to PPF in alkaline solution (pH 12) allowed to detect a, short lifetime, ESR signal corresponding to a phenoxyl radical. This finding was confirmed by a UV-visible study, resulting in the appearance of 427 nm peak and the disappearance of the peak located at 239 nm. The 291 nm peak remained unchanged. The identification of the end-product of the reaction of PPF with ONOO- needs further investigations. [less ▲]

Detailed reference viewed: 11 (6 ULg)
Full Text
Peer Reviewed
See detailPropofol scavenges reactive oxygen species and inhibits the protein nitration induced by activated polymorphonuclear neutrophils
Thiry, J. C.; Hans, Pol ULg; Deby-Dupont, G. et al

in European Journal of Pharmacology (2004), 499(1-2), 29-33

Activated polymorphonuclear neutrophils may damage tissues through the release of biochemical mediators. Among them, peroxynitrite is responsible for hydroxylation reactions and nitration of proteins, or ... [more ▼]

Activated polymorphonuclear neutrophils may damage tissues through the release of biochemical mediators. Among them, peroxynitrite is responsible for hydroxylation reactions and nitration of proteins, or is metabolised into nitrate. We investigated the effect of propofol on the production of reactive oxygen species, the nitration of proteins and the formation of nitrate by activated human polymorphonuclear neutrophils. Propofol dose-dependently inhibited chemiluminescence, nitration of proteins and nitrate production in a concentration range from 10(-3) to 10(-6) mM. A significant correlation was observed between the logarithm of propofol concentration and the intensity of chemiluminescence (r(2) = 0.90), the nitration of proteins (r(2) = 0.67) and the production of nitrate (r(2) = 0.79). Those results are consistent with the scavenging effect of propofol on peroxynitrite and could confer a protective property to propofol in pathological situations involving polymorphonuclear neutrophils activation. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 25 (10 ULg)
Full Text
Peer Reviewed
See detailProportion of extended-spectrum ß-lactamase-producing Enterobacteriaceae in community setting in Ngaoundere, Cameroon
LONCHEL, Carine Magoué; MEEX, Cécile ULg; Gangoué-Piéboji, Joseph et al

in BMC Infectious Diseases (2012), 12

BACKGROUND: There is no information regarding the resistance mechanisms of extended-spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae in community setting in Cameroon. The current study aimed to ... [more ▼]

BACKGROUND: There is no information regarding the resistance mechanisms of extended-spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae in community setting in Cameroon. The current study aimed to determine the proportion of ESBLs in Enterobacteriaceae isolated in the community and to analyse some risk factors associated with ESBL carriage. METHODS: Faecal samples were collected from 208 different outpatients and 150 healthy student volunteers between 3 January and 3 April 2009. Enterobacterial isolates resistant to third-generation cephalosporins were screened for ESBL production by the double-disk synergy test. Presumptive ESBL-producing isolates with positive synergy test were identified by Mass Spectrometry using the BioTyper MALDI-TOF. For such ESBL positive isolates, antibiotic susceptibility was determined by the Vitek 2 system. PCR and sequencing were performed for the detection of different types of ESBL genes in presumptive ESBL-producing isolates. Statistical methods were used for the univariate calculation of risk factors. RESULTS: During the study period, a total of 358 faecal samples were analysed; 58 of such samples (16%) showed an ESBL phenotype and were confirmed by PCR. The proportion of ESBL producers in faecal carriage was statistically different between outpatients and student volunteers (23.1% vs. 6.7%: p < 0.000). According to a univariate analysis, previous use of antibiotics (ciprofloxacin) appeared to be a risk factor for ESBL carriage (p < 0.05).Escherichia coli was the species most frequently isolated among the ESBL producers in outpatients (66.7%) and student volunteers (90%). Isolates showed additional resistance to gentamicin, ciprofloxacin and trimethoprim/sulfamethoxazole but none of them was resistant to temocillin, amikacin or meropenem. Most of the strains (97%) produced a CTX-M group 1 enzymes [CTX-M-15 (98%) or CTX-M-1 (2%)] and the remaining strains produced SHV-12 enzyme (3%). CONCLUSIONS: The use of drugs such as amoxicillin, ciprofloxacin and trimethoprim/sulfamethoxazole does not seem appropriate for empirical treatment because of emerging resistance. The implementation in Cameroon or in other African countries of methods of screening ESBL-producing organisms in routine laboratories is of great importance in order for us to offer patients appropriate treatment and for infection control efforts to succeed. [less ▲]

Detailed reference viewed: 24 (6 ULg)
Full Text
See detailThe proportion of ungrazed area of the pasture (PUP) determines when forage intake and diet quality decline in grazing systems
Benvenutti, Marcelo A.; Pavetti, Daniel R.; Cangiano, Carlos A. et al

in Proceedings of the 22nd International Grassland Congress (2013)

Detailed reference viewed: 23 (10 ULg)
Full Text
See detailPropos [sur le classement des universités belges dans Le Nouvel Observateur]
Durand, Pascal ULg

Article for general public (1998)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailA propos d'un cas de chylothorax compliquant une sclérose de varices oesophagiennes
Detry, Olivier ULg; Dekoster, Guy ULg; Honoré, Pierre ULg et al

in Lyon Chirurgical (1994), 90(1), 45-47

Chylothorax is an exceptional complication of endoscopic sclerotherapy of bleeding esophageal varices. We found only three cases in the literature. We report a fourth observation. We discuss the different ... [more ▼]

Chylothorax is an exceptional complication of endoscopic sclerotherapy of bleeding esophageal varices. We found only three cases in the literature. We report a fourth observation. We discuss the different etiologies and the different therapeutic approaches of these unusual chylothorax. [less ▲]

Detailed reference viewed: 20 (2 ULg)
See detailA propos de La Censure invisible
Durand, Pascal ULg

Conference given outside the academic context (2008)

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailA propos de la réticence à l’immunothérapie spécifique chez les personnes allergiques : les nouvelles données de la littérature
Dezfoulian, Bita ULg; Caucanas, Marie ULg; Wauters, Odile ULg et al

in Revue Médicale de Liège (2010)

The increasing number of allergic subjects and the alteration of their quality of life are major concerns of public health. Symptomatic treatments of allergic diseases are not always able to improve the ... [more ▼]

The increasing number of allergic subjects and the alteration of their quality of life are major concerns of public health. Symptomatic treatments of allergic diseases are not always able to improve the patient’s complaints. Allergic exploration aims to identify IgE-dependant mechanisms and subsequently to prove the responsibility of the detected allergen in the allergic disease. The efficacy of the specific immunotherapy (SIT ) using allergens in either subcutaneous or sublingual forms has been proven in rhinitis, conjunctivitis, asthma and IgE-induced reactions to hymenoptera venom. The lack of training in allergology is an important reticence of general practitioners and specialists to prescribe SIT . Furthermore, the duration of the treatment and its important cost in Belgium (where, only venom SIT is reimbursed by the Social Security) interfere significantly with the compliance of the patients. [less ▲]

Detailed reference viewed: 45 (3 ULg)
See detailA propos de la société agricole...
Thilmany, Jean ULg

in Revue Générale de Fiscalité [= RFG] (1981)

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailPROPOS DISPARATES AUTOUR DE LA GÉOGRAPHIE PHYSIQUE
Ek, Camille ULg

in Bulletin de la Société géographique de Liège (2009), 52

Rambling thoughts about physical geography Theories and paradigms succeed each other as time passes by. Some of the paradigms display a strong tendency to degenerate into laws and rules. Applied research ... [more ▼]

Rambling thoughts about physical geography Theories and paradigms succeed each other as time passes by. Some of the paradigms display a strong tendency to degenerate into laws and rules. Applied research requires team work and hierarchy. It should not be the only kind of research. Financial support is essential to support fundamental research, some of which must remain independent. Systemic approach to research, even in physical geography, thrusts the Human to the forefront. Man becomes an agent, as well as a subject to the process. Research should be structured and open to provide us with the most essential elements necessary, to correctly validate the theories and to be useful to mankind. [less ▲]

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailA propos du Drosera peltata et de la standardisation de la teinture de Drosera
Leclercq, Joëlle; Angenot, Luc ULg

in Journal de Pharmacie de Belgique (1984), 39(5), 269-274

The authors describe Drosera peltata , an Asiatic species newly appeared on the European marke, and give a method of identification and quantitative determination of plumbagin to standardize the drug and ... [more ▼]

The authors describe Drosera peltata , an Asiatic species newly appeared on the European marke, and give a method of identification and quantitative determination of plumbagin to standardize the drug and mainly the tincture that is used in pharmaceutical preparations against cough. [less ▲]

Detailed reference viewed: 49 (1 ULg)
See detailPropos sur Jacques Lizène
Durand, Pascal ULg

in Botquin, Jean-Michel (Ed.) Jacques Lizène (tome III) (2009)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailPropos sur l’imprévision : l’arrêt Scafom International et son contexte belge, européen et international
Biquet, Christine ULg

in Moore, Benoît (Ed.) Mélanges Jean-Louis Baudouin (2012)

Detailed reference viewed: 17 (0 ULg)
Full Text
See detailPropos sur le Zinc
Pirard, Eric ULg

Conference given outside the academic context (2014)

Detailed reference viewed: 20 (8 ULg)
Full Text
Peer Reviewed
See detailPropos sur un système de comptabilité agricole par ordinateur
Debouche, Charles ULg; Ramlot, Pierre ULg; Vanorle, L.

in Annales de Gembloux (1974), (80), 187-199

Detailed reference viewed: 52 (8 ULg)