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See detailNonparametric regression with cross-sectional data: an alternative to conditional product-limit estimators
Heuchenne, Cédric ULg; Laurent, Géraldine ULg

E-print/Working paper (2014)

Suppose the random vector (X,Y) satisfies the nonparametric regression model Y=m(X)+varepsilon, where m(x)=E[Y|X=x] and sigma²(x)=Var[varepsilon|X=x] are unknown smooth functions and the error varepsilon ... [more ▼]

Suppose the random vector (X,Y) satisfies the nonparametric regression model Y=m(X)+varepsilon, where m(x)=E[Y|X=x] and sigma²(x)=Var[varepsilon|X=x] are unknown smooth functions and the error varepsilon has zero mean and finite variance conditionally on X=x. The pair (X,Y) is obtained by cross-sectional sampling involving left-truncated and right-censored responses. The considered model is completely nonparametric but the conditional truncation distribution is assumed to be known. The novelty of this work is twofold: first, it extends the results on cross-sectional data to the conditional case and second, it generalizes the length bias results in the conditional case to right censoring and to any truncation distribution. New estimators for m(.) and sigma²(.) are constructed and relevant tools are used to quickly provide the main asymptotic properties for this kind of estimators. Extensive simulations are carried out and show that the new estimators outperform classical nonparametric estimators for left-truncated and right-censored data (when the truncation model is known). Finally, a data set on the mortality of diabetics is analyzed. [less ▲]

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See detailNonparametric regression with parametric selection bias
Heuchenne, Cédric ULg; Laurent, Géraldine ULg

in Proceedings of the 14th Conference of the ASMDA International Society (ASMDA2011) (2011, June)

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See detailNonparametric subspace identification of nonlinear structures - Application to a spacecraft
Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Proceedings of the 54th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference (2013, April)

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure by exploiting a new nonlinear subspace identification method formulated in the frequency ... [more ▼]

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure by exploiting a new nonlinear subspace identification method formulated in the frequency domain, referred to as the FNSI method. The modal parameters of the underlying linear structure and the coefficients of the nonlinear internal forces will be estimated by this approach. Moreover, because a priori knowledge about nonlinear behaviour may be limited, the paper also proposes a nonparametric spline-based modelling strategy, encapsulated in the FNSI method. The application of interest is the SmallSat spacecraft developed by EADS-Astrium, which possesses an impact-type nonlinear device consisting of eight mechanical stops limiting the motion of an inertia wheel mounted on an elastomeric interface. [less ▲]

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See detailNonpharmacological management
Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 76

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See detailNonPharmacological modalities, nutraceuticals and dietary supplements as therapies
Henrotin, Yves ULg; Marty, Marc; Mobasheri, Ali

in Addressing Unmet Needs in Osteoarthritis (2013)

This chapter discusses and critically appraises the nonpharmacological approaches that are currently available

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See detailNonpharmacological Therapies in the Management of Osteoarthritis
Henrotin, Yves ULg

Book published by Bentham Science Publishers Ltd. (2012)

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See detailNonprofit Organisations and Social Economy: Two Ways of Understanding the Third Sector
Mertens de Wilmars, Sybille ULg

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (1999), 70:3

The term third sector refers to a set of organizations which are neither capitalist, nor governmental. First of all, this paper aims to extent B. Gui's unitary approach to the third-sector (1991) by ... [more ▼]

The term third sector refers to a set of organizations which are neither capitalist, nor governmental. First of all, this paper aims to extent B. Gui's unitary approach to the third-sector (1991) by focusing on the distinction between third sector and state-owned bodies. Next I propose to translate the non capitalist and the non governmental conditions into operational criteria. I show that these criteria vary according to the nature of the organizations (general interest versus mutual interest). This statement allows me to justifiy the emergence of two different ways of understanding the third-sector in anglo-saxon and french-speaking traditions. [less ▲]

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See detailNonradial nonadiabatic stellar pulsations: A numerical method and its application to a beta Cephei model
Dupret, Marc-Antoine ULg

in Astronomy and Astrophysics (2001), 366

A new general method for the computation of nonradial nonadiabatic oscillations of a given stellar model is presented for a linear approximation. A simple and useful modelling of the atmosphere is ... [more ▼]

A new general method for the computation of nonradial nonadiabatic oscillations of a given stellar model is presented for a linear approximation. A simple and useful modelling of the atmosphere is included, allowing to obtain credible values for the eigenfunctions in the atmosphere. Some of the results obtained for a 10 M[SUB]sun[/SUB] model are shown as an illustration. Our study opens the way to different applications. Better theoretical line-profile variations could be obtained from our method, allowing a more detailed comparison with observations. More generally, our study is relevant for asteroseismology, giving a way for a better knowledge of stellar interiors. [less ▲]

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See detailNonradial oscillations of solar models with an initial discontinuity in hydrogen abundance
Boury, A.; Scuflaire, Richard ULg; Noels-Grötsch, Arlette ULg et al

in Hill, H. A.; Dziembowski, W. A. (Eds.) Nonradial and Nonlinear Stellar Pulsation: Proceedings of a Workshop Held at the University of Arizona in Tucson, March 12 – 16, 1979 (1980)

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See detailNonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial
Ginzler, Ellen M; Wofsy, David; Isenberg, David et al

in Arthritis and Rheumatism (2010), 62(1), 211-221

OBJECTIVE: To assess the effect of mycophenolate mofetil compared with intravenous pulses of cyclophosphamide on the nonrenal manifestations of lupus nephritis. METHODS: Patients with active lupus ... [more ▼]

OBJECTIVE: To assess the effect of mycophenolate mofetil compared with intravenous pulses of cyclophosphamide on the nonrenal manifestations of lupus nephritis. METHODS: Patients with active lupus nephritis (renal biopsy class III, IV, or V) were recruited for the study (n = 370) and treated with mycophenolate mofetil (target dosage 3 gm/day) or intravenous cyclophosphamide (0.5-1.0 gm/m(2)/month), plus tapered prednisone, for 24 weeks. Nonrenal outcomes were determined using measures of whole body disease activity, including the British Isles Lupus Assessment Group (BILAG) disease activity index, the Safety of Estrogens in Lupus Erythematosus: National Assessment (SELENA) version of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and immunologic variables. RESULTS: Both treatments were effective on whole body disease activity in the systems examined, as indicated by changes in the classic BILAG index. With either treatment, remission was induced, notably in the mucocutaneous, musculoskeletal, cardiovascular/respiratory, and vasculitis systems, and flares were rare, as measured by the SELENA-SLEDAI. Levels of complement C3, C4, and CH50 and titers of anti-double-stranded DNA antibodies were normalized after treatment with either mycophenolate mofetil or intravenous cyclophosphamide. CONCLUSION: In addition to the efficacy of both treatments on the renal system, this analysis showed that remission could also be induced in other systems. There was no clear difference in efficacy between mycophenolate mofetil and intravenous cyclophosphamide in ameliorating either the renal or nonrenal manifestations. Mycophenolate mofetil is, therefore, a suitable alternative to cyclophosphamide for the treatment of renal and nonrenal disease manifestations in patients with biopsy-proven lupus nephritis. [less ▲]

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See detailNonresponsive Generalized Bacterial Infection Associated with Systemic Lupus Erythematosus in a Beauceron
Clercx, Cécile ULg; Mc Entee, Kathleen ULg; Gilbert, S. et al

in Journal of the American Animal Hospital Association (1999), 35(3, May-Jun), 220222224-8

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular ... [more ▼]

A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies. [less ▲]

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See detailNonribosomal peptides producing strains isolated from Bikalga and Soumbala fermented condiments of Burkina Faso
Savadogo, Aly; Chollet, Marlène; Tapi, Arthur et al

Conference (2009)

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See detailNonrigid registration and multimodality image fusion for 3D image-guided neurochirurgical planning and navigation
Verly, Jacques ULg; Vigneron, Lara M.; Petitjean, Nicolas et al

Conference (2004)

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See detailNonrigid registration and multimodality image fusion for 3D image-guided neurosurgery
Verly, Jacques ULg; Vigneron, Lara M.; Mercenier, Julien et al

Conference (2004)

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See detailA nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle.
Koltes, James E; Mishra, Bishnu P; Kumar, Dinesh et al

in Proceedings of the National Academy of Sciences of the United States of America (2009), 106(46), 19250-5

Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a ... [more ▼]

Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a recessive genetic defect. We assembled a 4-generation pedigree to identify the mutation underlying dwarfism in American Angus cattle. An adaptation of the Elston-Steward algorithm was used to overcome small pedigree size and missing genotypes. The dwarfism locus was fine-mapped to BTA6 between markers AFR227 and BM4311. Four candidate genes were sequenced, revealing a nonsense mutation in exon 15 of cGMP-dependant type II protein kinase (PRKG2). This C/T transition introduced a stop codon (R678X) that truncated 85 C-terminal amino acids, including a large portion of the kinase domain. Of the 75 mutations discovered in this region, only this mutation was 100% concordant with the recessive pattern of inheritance in affected and carrier individuals (log of odds score = 6.63). Previous research has shown that PRKG2 regulates SRY (sex-determining region Y) box 9 (SOX9)-mediated transcription of collagen 2 (COL2). We evaluated the ability of wild-type (WT) or R678X PRKG2 to regulate COL2 expression in cell culture. Real-time PCR results confirmed that COL2 is overexpressed in cells that overexpressed R678X PRKG2 as compared with WT PRKG2. Furthermore, COL2 and COL10 mRNA expression was increased in dwarf cattle compared with unaffected cattle. These experiments indicate that the R678X mutation is functional, resulting in a loss of PRKG2 regulation of COL2 and COL10 mRNA expression. Therefore, we present PRKG2 R678X as a causative mutation for dwarfism cattle. [less ▲]

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See detailA nonsmooth generalized-alpha scheme for flexible multibody systems with unilateral constraints
Chen, Qiong-zhong; Acary, Vincent; Virlez, Geoffrey ULg et al

in International Journal for Numerical Methods in Engineering (2013), 96(8), 487-511

Mechanical systems are usually subjected not only to bilateral constraints but also to unilateral constraints. Inspired by the generalized-alpha time integration method for smooth flexible multibody ... [more ▼]

Mechanical systems are usually subjected not only to bilateral constraints but also to unilateral constraints. Inspired by the generalized-alpha time integration method for smooth flexible multibody dynamics, this paper presents a nonsmooth generalized-alpha method, which allows a consistent treatment of the nonsmooth phenomena induced by unilateral constraints and an accurate description of the structural vibrations during free motions. Both the algorithm and the implementation are illustrated in detail. Numerical example tests are given in the scope of both rigid and flexible body models, taking account for both linear and nonlinear systems, and comprising both unilateral and bilateral constraints. The extended nonsmooth generalized-alpha method is verified through comparison to the traditional Moreau-Jean method and the fully implicit Newmark method. Results show that the nonsmooth generalized-alpha method benefits from the accuracy and stability property of the classical generalized-alpha method with controllable numerical damping. In particular, when it comes to the analysis of flexible systems, the nonsmooth generalized-alpha method shows much better accuracy property than the other two methods. [less ▲]

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See detailNonsmooth generalized-alpha scheme for the simulation of flexible multibody systems with impacts
Cardona, Alberto; Cavalieri, Federico; Bruls, Olivier ULg et al

Conference (2015, April)

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See detailNonspecific airway responsiveness of COPD horses : effects of environmental control
Vandenput, Sandrina ULg; Votion, Dominique ULg; Anciaux, N. et al

in Pflügers Archiv : European Journal of Physiology (1996), 431(6), 324

Detailed reference viewed: 17 (5 ULg)