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See detailPlants associated with Tentaculites in a new Early Devonian locality from Morocco.
Gerrienne, Philippe ULg; Fairon-Demaret, Muriel ULg; Galtier, J et al

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailPlants bioclimatic affinity groups in China : observed vs. simulated ranges
Huang, K.; Zheng, Z.; François, Louis ULg et al

in The Open Ecolology Journal (2010), 3

Predicting future ecosystems changes is necessary for better managing human resources. Such forecasting requires robust vegetation models which have been tested versus observed field data. Nowadays, it is ... [more ▼]

Predicting future ecosystems changes is necessary for better managing human resources. Such forecasting requires robust vegetation models which have been tested versus observed field data. Nowadays, it is very common that a simulation model is firstly validated using modern observed data and then tested versus palaeodata. In a sense, ecological data represent the natural laboratory for modelers. Thus, palaeo and actuo-ecological data are key points when dealing with predicting future changes. The present work represents the first step in such data-model comparison approach. Here, we use only modern plants distributions to test the robustness of our ecosystems definitions and use these definitions for testing a dynamic vegetation model. We have defined twenty-nine Bioclimatic affinity groups (BAGs) for 196 dominant plant species including trees, shrubs and herbs in China. These BAGs are characterized by the phenology and the climatic tolerances of the species they include. They are detailed enough to describe all vegetation types in China including the tropical, the subtropical, the temperate and the high altitude (Tibet Plateau) ecosystems. The climatic thresholds of these 29 BAGs were then used to test and validate a global dynamic vegetation model (CARAIB). The simulated BAGs are in good agreement with those observed in China, especially in the Tibetan Plateau and in the subtropical ecosystems. Broadly, all simulated BAGs fit quite well with the modern distribution. However, they all cover larger areas than the observed distributions, especially in the temperate region and in some areas in the northwest and the tropical zone. These discrepancies between simulated and observed distributions are related to the fact that the vegetation models simulate potential distributions. In China during recent decades natural ecosystems, mostly in the temperate zone, have been strongly altered in their species composition and geographical extent by different human activities such as the intense cultivation, deforestation, introduction of fast growing species and grazing. [less ▲]

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See detailThe plantslabels package
Merciadri, Luca ULg

Computer development (2010)

This is the manual of the plantslabels package that I wrote. Briefly, this package aims at helping the LaTeX user at writting labels for plants. For more info on it, please look at the manual in the ... [more ▼]

This is the manual of the plantslabels package that I wrote. Briefly, this package aims at helping the LaTeX user at writting labels for plants. For more info on it, please look at the manual in the tarball. [less ▲]

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See detailUne plaquette filigranée du XIIIe siècle découverte à Stavelot. Identification et conservation
Van den Bossche, Benoît ULg; Dewanckel, Gilberte; Paquet, Pierre ULg et al

in Bulletin de l'Institut Royal du Patrimoine Artistique (1991), 23

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See detailPlaskett's star: analysis of the CoRoT photometric data
Mahy, Laurent ULg; Gosset, Eric ULg; Baudin, F. et al

in Astronomy and Astrophysics (2011), 525

Context. The second short run (SRa02) of the CoRoT space mission for asteroseismology was partly devoted to stars belonging to the Mon OB2 association. An intense monitoring has been performed on Plaskett ... [more ▼]

Context. The second short run (SRa02) of the CoRoT space mission for asteroseismology was partly devoted to stars belonging to the Mon OB2 association. An intense monitoring has been performed on Plaskett's star (HD 47129) and the unprecedented quality of the light curve allows us to shed new light on this very massive, non-eclipsing binary system. <BR /> Aims: We particularly aimed at detecting periodic variability that might be associated with pulsations or interactions between both components. We also searched for variations related to the orbital cycle that could help to constrain the inclination and the morphology of the binary system. <BR /> Methods: We applied an iterative Fourier-based prewhitening and a multiperiodic fitting procedure to analyse the time series and extract the frequencies of variations from the CoRoT light curve. We describe the noise properties to tentatively define an appropriate significance criterion and, in consequence, to only point out the peaks at a certain significance level. We also detect the variations related to the orbital motion and study them with the NIGHTFALL programme. <BR /> Results: The periodogram computed from Plaskett's star CoRoT light curve mainly exhibits a majority of peaks at low frequencies. Among these peaks, we highlight a list of 43 values, notably including two different sets of harmonic frequencies whose fundamental peaks are located at about 0.07 and 0.82 d[SUP]-1[/SUP]. The former represents the orbital frequency of the binary system, whilst the latter could probably be associated with non-radial pulsations. The study of the 0.07 d[SUP]-1[/SUP] variations reveals a hot spot most probably situated on the primary star and facing the secondary. <BR /> Conclusions: The investigation of this unique dataset constitutes a further step in the understanding of Plaskett's star. These results provide a first basis for future seismic modelling and put forward the probable existence of non-radial pulsations in Plaskett's star. Moreover, the fit of the orbital variations confirms the problem of the distance of this system which was already mentioned in previous works. A hot region between both components renders the determination of the inclination ambiguous. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany and Spain.Table 2 is only available in electronic form at <A href="http://www.aanda.org">http://www.aanda.org</A> [less ▲]

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See detailPlasma alpha-1-acid glycoprotein and haptoglobin changes in acute myocardial infarction: relationship to early mortality
Chapelle, Jean-Paul ULg; Smeets, J. P.; Sourdeau, L. et al

Poster (1980, November)

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See detailPlasma Beta-Endorphin Response of Thoroughbred Horses to Maximal Exercise
Art, Tatiana ULg; Franchimont, P.; Lekeux, Pierre ULg

in Veterinary Record : Journal of the British Veterinary Association (1994), 135(21), 499-502

Ten horses underwent a standardised strenuous treadmill exercise test, before, during and after which measurements were made of plasma beta-endorphin and cortisol concentrations, blood lactate, glucose ... [more ▼]

Ten horses underwent a standardised strenuous treadmill exercise test, before, during and after which measurements were made of plasma beta-endorphin and cortisol concentrations, blood lactate, glucose, haemoglobin and pH, the activities of creatine kinase, lactate dehydrogenase and aspartate amino-transferase, and heart rate, oxygen uptake and expired minute volume. The correlations between the exercise-induced response of beta-endorphin and the changes observed in the other physiological measurements were examined. There was a large variation in the beta-endorphin response of the horses to exercise. The increase in beta-endorphin was correlated significantly and inversely with the treadmill velocity at which maximal oxygen uptake was reached. It was also significantly and directly correlated with the heart rate during recovery, the increase in plasma lactate concentration and the change in blood pH, indicating that the exercise-induced increase in beta-endorphin concentration was smaller in horses with a higher aerobic capacity [less ▲]

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See detailPlasma bovine pregnancy-associated glycoprotein concentrations throughout gestation in relationship fetal number in the cow
Patel, Osman V; Sulon, Joseph ULg; Beckers, Jean-François ULg et al

in European Journal of Endocrinology (1997), 137

This study characterized the peripheral plasma bovine pregnancy-associated glycoprotein (bPAG) profile throughout gestation and examined the effect of stage of gestation and fetal number on this profile ... [more ▼]

This study characterized the peripheral plasma bovine pregnancy-associated glycoprotein (bPAG) profile throughout gestation and examined the effect of stage of gestation and fetal number on this profile in Holstein cows after non-surgical embryo transfer. Cows (n = 12) were divided into three groups: group 1 = normal singleton pregnancies (n = 5); group 2 = normal twin pregnancies (n = 5); group 3 = abnormal twin pregnancies (n = 2). Blood was collected about every third day from day 0 (defined as the first day of standing estrus), then daily for the last 10 days of gestation, and sampling was stopped one day postpartum. The time-related changes in plasma bPAG concentrations were significantly (P < 0.01) affected by the stage of gestation and fetal number (P < 0.01), except during the last 10 days of gestation. In both normal pregnancy groups, bPAG concentration increased rapidly during the first trimester (0.5 +/- 0.1 to 14.6 +/- 1.7 ng/ml and 1.0 +/- 0.6 to 21.8 +/- 4.8 ng/ml, in singleton and twin-bearing groups respectively), then progressively between days 160 and 20 prepartum (31.6 +/- 6.2 to 114.3 +/- 31.3 ng/ml and 41.6 +/- 7.4 to 155.8 +/- 36.6 ng/ml in singleton and twin-bearing cows respectively). The mean concentration between days 20 and 10 prepartum approximately tripled (P < 0.001) in both these groups of cows (114.3 +/- 31.1 to 493.0 +/- 75.3 ng/ml and 155.8 +/- 36.6 to 409.3 +/- 114.7 ng/ml in singleton and twin-bearing cows respectively), but between days 10 prepartum and parturition the values increased about threefold (P < 0.01) in the singleton group (493.0 +/- 75.3 to 1352.8 +/- 286.5 ng/ml) and fivefold (P < 0.001) in the twin-bearing group (409.3 +/- 114.7 to 2154.0 +/- 505.7 ng/ml). The two cows in group 3 that gave birth prematurely to a stillborn calf or to a schistosomus reflexus calf exhibited an aberrant bPAG profile. Our results indicate that peripheral bPAG concentrations are correlated to the stage of gestation and fetal number, and that the profile of the peripheral plasma concentrations provides a useful indication of the feto-placental status. [less ▲]

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See detailPlasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group.
Fernández de Larrea, C; Kyle, RA; Durie, BG et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2013), 27(4), 780-91

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See detailPlasma composition in the Jovian magnetosphere
Radioti, Aikaterini ULg; Krupp, N.; Woch, J. et al

Poster (2004, August 03)

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See detailPlasma Concentration of Estradiol Following Transdermal Administration of Systen 50 or Menorest 50
Reginster, Jean-Yves ULg; Albert, Adelin ULg; Deroisy, Rita ULg et al

in Scandinavian Journal of Rheumatology. Supplement (1996), 103

Circulating levels of 17 beta estradiol (E2) following the administration of fixed doses of E2, show a great variability in kinetics depending upon the product administrated, the routes of administration ... [more ▼]

Circulating levels of 17 beta estradiol (E2) following the administration of fixed doses of E2, show a great variability in kinetics depending upon the product administrated, the routes of administration, and the interindividual variations in absorption and metabolism. This might have important implications both in terms of tolerance and effectiveness. Two new forms of transdermal E2 (SYSTEN Cilag and MENOREST Rhone-Poulenc Rorer) have been recently accepted in Europe for the treatment of climacteric symptoms. The present study was undertaken to compare the pharmacokinetic characteristics of plasma E2 profile under these two drugs. It was carried out in 30 healthy postmenopausal volunteers according to good clinical practice after informed consent, as a single blind, randomised, cross-over study during the classical wearing period of 4 days. Plasma E2 concentration was determined 24 hours before, 1/2 hour before and then 2, 4, 8, 12, 24, 48, 72, 84, 96 hours after the first patch administration. E2 measurement was performed using a specific direct radioimmunoassay developed in the FRH laboratories. The main criteria for this method were an intraassay coefficient of variation (CV) less than 6%, an interassay CV less than 8% in a concentration range of 15-140 pg/ml and a quantitative detection limit (LOQ) of 2.7 pg/ml with a 20% CV. The following kinetic parameters were analysed: C(max), C(mean), C96 and MRT. The bioequivalence was assessed by analysis of variance of C(max), C(mean), C96 and AuC after logarithmic transformation, complemented by Westlake test (95%). Data show that these two products are identical in terms of C(max) but C(mean), C96 and AuC are statistically greater when MENOREST 50(R) is administered; furthermore, E2 levels decrease more rapidly and more deeply with SYSTEN 50 than MENOREST 50. The differences of pharmacokinetic profiles after administration of two different forms of the same dose of 50 micrograms transdermal 17 beta estradiol might have important medical consequences. [less ▲]

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See detailPlasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses suffering from juvenile digital degenerative osteoarthropathy
Lejeune, Jean-Philippe ULg; Franck, Thierry ULg; Gangl, Monika et al

in Veterinary Research Communications (2007), 31(2), 185-195

Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to ... [more ▼]

Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to affect the anabolism of cartilage matrix molecules. A group of 30 Ardenner horses reared under standardized conditions from weaning were evaluated periodically from 15 to 28 months of age to detect the early manifestations of the disease. At the end of this period, horses were classified in two pathological groups related to the degree of interphalangeal degenerative osteoarthropathy based on clinical and radiographic evaluations: healthy (46.7%) and pathological (53.3%) horses. Seven sequential blood samples were taken from each horse (during the evaluation period) to study the variation of IGF-I plasma concentration. We tested the variations of the IGF-I plasma concentration during growth, and the effect of sex and of pathological classes. Significant variations were observed during the research period, with a maximum value corresponding to spring and a minimum in autumn. A significant reduction of the IGF-I plasma concentration was also observed in the pathological horses (433.5 +/- 19.5 ng/ml) compared to the healthy horses (493.9 +/- 18.2 ng/ml). An alteration in the level of this growth factor could induce a disregulation of the mechanisms involved in the local control of joint and bone tissue development. [less ▲]

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See detailPlasma concentrations of a type II collagen-derived peptide and its nitrated form in growing ardenner sound horses and in horses suffering from juvenile digital degenerative osteoarthropathy
Lejeune, Jean-Philippe ULg; Serteyn, Didier ULg; Gangl, Monika et al

in Veterinary Research Communications (2007), 31(5), 591-601

Several breeds of draft horses suffer from degenerative digital osteoarthropathy, resulting in a reduced active lifespan. A group of 30 Ardenner horses was followed, in standardized conditions, from 15 to ... [more ▼]

Several breeds of draft horses suffer from degenerative digital osteoarthropathy, resulting in a reduced active lifespan. A group of 30 Ardenner horses was followed, in standardized conditions, from 15 to 28 months of age to detect the early manifestations of the disease. The severity of the disease was assessed according to a personal grading system including clinical and radiographic items. Coll 2-1, a peptide of the helical region of type II collagen, and its nitrated form (Coll 2-1 NO2) were assayed in blood plasma collected at 452 +/- 18 days, 504 +/- 20 days, 558 +/- 18 days, 613 +/- 19 days, 675 +/- 19 days, 752 +/- 21 days and 852 +/- 19 days of age. At the end of the follow-up period, 53.3% of Ardenner horses were affected by a degenerative digital osteoarthropathy. A significant effect (p < 0.05) of time, sex and pathology was observed for Coll 2-1 NO2. Variations of Coll 2-1 were not significant except for the time effect. The elevation of Coll 2-1 NO2 in the pathological group could indicate an inflammatory process during the growth of the affected horses, as nitration of tyrosine is mediated through reactive oxygen/nitrogen species and/or myeloperoxidase activity. Coll 2-1 NO2 appears to be an interesting early marker of cartilage degradation and oxidation in degenerative osteoarthropathy. [less ▲]

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See detailPlasma concentrations of bovine pregnancy-associated glycoprotein (bPAG) do not differ during the first 119 days between ongoing pregnancies derived by transfer of in vivo and in vitro produced embryos
Breukelman, S. P.; Perenyi, Z.; de Ruigh, L. et al

in Theriogenology (2005), 63(5), 1378-1389

Calves derived from IVP embryos may suffer from the large offspring syndrome that has been related to effects of in vitro culture on the intrinsic quality of the embryo. Limited information is available ... [more ▼]

Calves derived from IVP embryos may suffer from the large offspring syndrome that has been related to effects of in vitro culture on the intrinsic quality of the embryo. Limited information is available on the role of the placenta in such cases. In this study, bovine pregnancy-associated glycoprotein (bPAG) was used as a marker to test whether placental function is influenced by the route of embryo production. Therefore, from day 7 until day 119 of ongoing gestations, resulting from transfer of MOET (n = 53), IVP-co-culture (n = 21) and IVP-SOF (n = 38) embryos, bPAG levels were compared in peripheral plasma of recipients. Plasma progesterone levels were compared as well. From day 25 of gestation onwards, bPAG could be detected in all recipients and the levels were significantly influenced by the day of gestation. Although IVP calves were significantly heavier than the in vivo produced calves, this difference was not reflected in the bPAG profiles of the embryo production groups. Yet, the mean bPAG level of the three last sampling moments (days 105-119) tended to be positively related to the birth weight of the calves, irrespective of the embryo production technique. Progesterone concentrations were not influenced by route of embryo production, but were significantly affected by parity of the recipient and day of gestation [less ▲]

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See detailPlasma concentrations of myeloperoxidase in endurance and 3-day event horses after a competition
Art, Tatiana ULg; Franck, Thierry ULg; Gangl, M. et al

in Equine Veterinary Journal. Supplement (2006), 36

REASON FOR PERFORMING STUDY: In man, exercise of any type has been shown to induce neutrophil degranulation and respiratory burst activity, as well as an increase in plasma myeloperoxidase (MPO), a ... [more ▼]

REASON FOR PERFORMING STUDY: In man, exercise of any type has been shown to induce neutrophil degranulation and respiratory burst activity, as well as an increase in plasma myeloperoxidase (MPO), a specific enzyme of neutrophil azurophilic granules with a strong oxidative activity. Until now, it is not known whether this is the same in horses. OBJECTIVES: To study whether degranulation of blood neutrophils may be induced by exercise by measuring the total concentration of MPO and assess the possible influence of type of competition on this exercise-induced adjustment. METHODS: Blood was sampled before, and 30 min after, the course, in 9 ponies performing the Phase D of a national 3-day event championship (CIC*), and in 7 endurance horses participating at the European endurance championship 2005. White blood cells and granulocytes, total plasma proteins, creatine phosphokinase (CK), and total MPO contents were determined from blood samples. In addition, blood was taken from all ponies and 4 of the endurance horses 5 min after completion of the course to give some idea of the intensity of exercise. RESULTS: The mean blood lactate was 15.8 +/- 5.8 mmol/l after the CIC* and 2.7 +/- 0.2 mmol/l after the 160 km course. Performing both competitions induced a significant increase in CK and MPO. After the endurance course, the number of granulocytes significantly increased. Whilst there was no significant correlation between the measurements in CIC* ponies, MPO was significantly correlated with granulocyte count (r2 = 0.776) and CK (r2 = 0.586) in endurance horses. CONCLUSIONS: Intense exercise induces an activation of blood granulocytes, with degranulation of neutrophils and release of MPO. The plasmatic MPO concentration after endurance was higher than the values reported in some inflammatory pathological conditions. POTENTIAL RELEVANCE: This phenomenon may partly contribute to the occurrence of an exercise-induced oxidative stress and to the alteration of muscular membrane permeability. Further studies should be conducted to assess the possible relationship between MPO concentration and markers of oxidative stress in performance horses [less ▲]

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See detailPlasma concentrations of pregnancy-associated glycoprotein-1 (PAG-1) in high producing dairy cows suffering early fetal loss during the warm season
Lopez-Gatius, F.; Hunter, R. H. F.; Garbayo, J. M. et al

in Theriogenology (2007), 67(8), 1324-1330

The present study was designed to establish whether plasma pregnancy-associated glycoprotein-1 (PAG-1) measurements during the early fetal period can be associated with early fetal loss. Blood samples ... [more ▼]

The present study was designed to establish whether plasma pregnancy-associated glycoprotein-1 (PAG-1) measurements during the early fetal period can be associated with early fetal loss. Blood samples were obtained and ultrasound controls performed on days 35, 42, 49, 56, and 63 of gestation or until pregnancy loss from 98 lactating dairy cows. Radioimmunoassay systems were used to determine PAG-1 and progesterone concentrations. Of the 98 pregnancies investigated 18 (18.4%) suffered early fetal loss: 15 (18.5%) in cows carrying singletons, and 3 (16.7%) in twin pregnancies. In cows suffering pregnancy loss, all living embryos registered on day 35 seemed normal in size and development in all weekly ultrasound controls before fetal expulsion. Using analysis of variance, plasma PAG-1 and progesterone values were not different between no loss and fetal loss groups for every gestation period. Based on the odds ratio, and considering only PAG-1 values obtained on day 35 of gestation, the risk of fetal loss was 10 and 6.8 times more likely in cows with low (< 2.5 ng/ml) and high (> 4 ng/ml) PAG-1 values, respectively, than in cows with medium PAG-1 values, used as reference. Of the 10 inseminating bulls included in the study, one was related to increased fetal loss by odds ratio of 21.7, whereas one bull was attributed fetal loss rate reduced by odds ratio of 12.5 (1/0.08) These findings can have a clear clinical application: PAG-1 measurements from one single sample taken on clay 35 of gestation provided more useful information than a series of values obtained from day 35 to 63 of gestation, and can be indicators of subsequent fetal loss. (c) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailPlasma concentrations of pregnancy-associated glycoproteins measured using anti-bovine PAG-2 antibodies on Day 120 of gestation predict abortion in dairy cows naturally infected with Neospora caninum.
Garcia-ispierto, I; Almeria, S; Serrano, B et al

in Reproduction in Domestic Animals (2013), 48

The present study sought to determine: (i) the effects of Neospora caninum infection and twin pregnancy on plasma pregnancy-associated glycoprotein-2 (PAG-2) concentrations throughout pregnancy and (ii ... [more ▼]

The present study sought to determine: (i) the effects of Neospora caninum infection and twin pregnancy on plasma pregnancy-associated glycoprotein-2 (PAG-2) concentrations throughout pregnancy and (ii) whether plasma PAG-2 concentrations could predict abortion in N. caninum-infected cows. The study was performed on a commercial Holstein-Friesian dairy herd in northeastern Spain and the final data included those recorded in 53 non-aborting and 19 aborting animals. Blood samples were collected immediately before pregnancy diagnosis (on Days 40, 90, 120, 150, 180 and 210 post-insemination) in non-aborting cows or until the time of abortion detection in aborting cows. General lineal models (GLM) repeated measures ANOVA revealed the different behavior of PAG-1 and PAG-2, and significant effects of Neospora seropositivity, cool season and twin pregnancy on plasma PAG-2 concentrations throughout gestation (between-subject effects). In addition, based on the odds ratios, the likelihood of abortion increased in Neospora-seropositive cows (by a factor of 7.0) compared to seronegative animals and decreased in cows with a high plasma PAG-2 concentration (>4.5 ng/ml) on Day 120 of pregnancy (by a factor of 0.24), compared to the remaining cows. In conclusion, there is a relationship between plasma PAG-2 concentrations and the risk of abortion in Neosporainfected dairy cows. Thus, plasma PAG concentrations measured using anti-boPAG-2 antiserum on Day 120 of gestation could serve as an indicator of the abortion risk in N. caninum infected animals; values <4.5 ng/ml indicating a high risk of abortion in chronically infected animals. [less ▲]

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See detailPlasma cystatin C for the detection of renal failure in obese patients
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Radermecker, Régis ULg et al

in Nephrology Dialysis Transplantation (2006), 21(S4), 214

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See detailPlasma enrichi en plaquettes et cicatrisation tendineuse : modèle sur rats
Kaux, Jean-François ULg; Drion, Pierre ULg; Colige, Alain ULg et al

in Annales de Réadaptation et de Médecine Physique (2011, October), 54(1), 123

Introduction: Le but de notre étude était de déterminer si une injection de plasma enrichi en plaquettes (PRP) pouvait améliorer et accélérer le processus de cicatrisation de tendons d'Achille de rats ... [more ▼]

Introduction: Le but de notre étude était de déterminer si une injection de plasma enrichi en plaquettes (PRP) pouvait améliorer et accélérer le processus de cicatrisation de tendons d'Achille de rats rompus. Matériel et méthode : Un défect de 5mm a été réalisé chirurgicalement au niveau de tendons d'Achille de 120 rats. Soixante rats ont reçu respectivement une infiltration de PRP ou PBS in situ après chirurgie. Vingt rats de chaque groupe ont été euthanasiés après 5, 15 et 30 jours. Quinze tendons de chaque groupe ont été directement soumis à un test de traction biomécanique jusqu'à rupture à l'aide de clamps de type "cryo-jaw" et ensuite collectés pour réaliser des analyses transcriptomiques. Des études histologique et biochimique ont également été réalisées sur les 5 tendons restant de chaque groupe. Résultats: Les tendons du groupe PRP étaient plus résistants à la rupture à 15 et 30 jours que ceux du groupe contrôle. La section transverse des tendons était significativement plus grande au sein du groupe PRP à J5 et J15. Les contraintes étaient significativement plus grandes au sein des tendons dans les phases tardives de cicatrisation. L'étude histologique montrait une augmentation de coloration pour les fibres de collagène à J5 au sein du groupe PRP, résultats confirmés par l'analyse biochimique montrant une augmentation de la concentration de collagène au sein du "cal" tendineux. L'expression de la ténomoduline, un marqueur de la différentiation des ténocytes, était significativement plus important au sein du groupe PRP à J5. Aucune différence significative en terme d'ARNm n'a été observée pou r le collagène de type III ni pour la MMP-9, à aucun temps, entre les 2 groupes. Conclusion : Une injection de PRP au sein de tendons d'Achille de rats rompus influence les phases précoces du la cicatrisation tendineuse, entrainant une meilleure résistance mécanique à la rupture. [less ▲]

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