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See detailRecent Advances in the Pharmacology of Quaternary Salts of Bicuculline
Seutin, Vincent ULg; Johnson, S. W.

in Trends in Pharmacological Sciences (1999), 20(7), 268-270

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See detailRecent advances in the study of lanthanide atoms and ions
Biémont, Emile ULg; Quinet, Pascal ULg

in Physica Scripta (2003), T105

We present an overview of the recent developments concerning the spectroscopic properties of lanthanide atoms and ions (Z = 57-71). This review is focussed on the advances made during the past twenty ... [more ▼]

We present an overview of the recent developments concerning the spectroscopic properties of lanthanide atoms and ions (Z = 57-71). This review is focussed on the advances made during the past twenty years regarding the analysis of the spectra, the transition probabilities, the radiative lifetimes and also the hyperfine structures and isotope shifts. Theoretical aspects as well as experimental measurements are both covered in this paper including bibliographical references up to the end of 2001. Some astrophysical implications of the new atomic data concerning the chemical composition of the sun are briefly reviewed. Emphasis is also put on the new database D.R.E.A.M. developed on a web site of Mons University in Belgium. [less ▲]

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See detailRecent advances in the synthesis of aliphatic polyesters by ring-opening polymerization
Jérôme, Christine ULg; Lecomte, Philippe ULg

in Advanced Drug Delivery Reviews (2008), 60(9), 1056-1076

Advanced drug delivery systems rely on the availability of biocompatible materials. Moreover, biodegradability is highly desirable in the design of those systems. Consequently, aliphatic polyesters appear ... [more ▼]

Advanced drug delivery systems rely on the availability of biocompatible materials. Moreover, biodegradability is highly desirable in the design of those systems. Consequently, aliphatic polyesters appear as a class of promising materials since they combine both properties. Nevertheless, their use in practical biomedical systems relies on clinical approval which not only depends on the material itself but also on its reproducible synthesis with the absence of residual toxics. The first sections of this review aim at reporting on the evolution of the initiators/catalytic systems and of the synthesis conditions (particularly the use of supercritical CO2 as polymerization medium) in order to produce aliphatic polyesters with controlled macromolecular parameters by still "greener" ways. In addition, the further development of delivery systems also depends on the synthesis of materials exhibiting novel properties, such as amphiphilicity or pH-sensitivity that are emerging from the active research in macromolecular engineering. Functionalizing aliphatic polyesters is quite tedious due to their sensitivity towards hydrolytic degradation. The last section of this review is discussing several strategies to obtain functional (co)polyesters of various architectures providing them with novel properties. [less ▲]

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See detailRecent advances in the synthesis of aliphatic polyesters by “click” chemistry
Riva, Raphaël ULg; Jérôme, Christine ULg; Jérôme, Robert ULg et al

Conference (2008, September 11)

Since the discovery of Sharpless and Meldal, the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is more and more popular in the field of macromolecular engineering owing to its robustness, its ... [more ▼]

Since the discovery of Sharpless and Meldal, the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is more and more popular in the field of macromolecular engineering owing to its robustness, its high tolerance to a wide range of functional groups without any need of protecting groups and the absence of side-products. This reaction is known to be a very efficient “click” reaction as defined by Sharpless. The chemical modification of aliphatic polyesters remains, at the time being, a very difficult task to achieve because of the very limited number of efficient chemical reactions, which can be implemented in the absence of chain degradation. The main purpose of this contribution is to report on the most recent advances on the use of CuAAC to derivatize aliphatic polyesters (Scheme 1). Interestingly enough, it was recently shown that CuAAC carried out onto aliphatic polyesters attached with either azides or alkynes is very efficient under mild conditions, which limit undesirable degradation. Several functional groups were grafted onto aliphatic polyesters by CuAAC without using any protection/deprotection reactions. The CuAAC is also very efficient to prepare aliphatic polyesters with various architectures as highlighted by the synthesis of graft copolymers, star-shaped copolymers and networks. This “click” chemistry has been combined with other polymerization mechanism such as ATRP in order to extend further the range of available polymers. [less ▲]

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See detailRecent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis.
Schulz, R.; Rassaf, T.; MASSION, Paul ULg et al

in Pharmacology & Therapeutics (2005), 108(3), 225-56

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial ... [more ▼]

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial NOS (NOS3). Biochemically, NOS consists of a flavin-containing reductase domain, a heme-containing oxygenase domain, and regulatory sites. NOS catalyse an overall 5-electron oxidation of one Nomega-atom of the guanidino group of L-arginine to form NO and L-citrulline. NO exerts a plethora of biological effects in the cardiovascular system. The basal formation of NO in mitochondria by a mitochondrial NOS seems to be one of the main regulators of cellular respiration, mitochondrial transmembrane potential, and transmembrane proton gradient. This review focuses on recent advances in the understanding of the role of enzyme and enzyme-independent NO formation, regulation of NO bioactivity, new aspects of NO on cardiac function and morphology, and the clinical impact and perspectives of these recent advances in our knowledge on NO-related pathways. [less ▲]

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See detailRecent and prospective decorrelation techniques for image processing
Comes, Serge; Maes, Stéphane; Van Droogenbroeck, Marc ULg

in Annales des Télécommunications = Annals of Telecommunications (1993), 48(7-8), 390-403

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See detailRecent and prospective decorrelation techniques for image processing
Comes, Serge; Maes, Stéphane; Van Droogenbroeck, Marc ULg

in International Symposium on Signals, Systems and Electronics, Proceedings (1992, September)

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See detailRecent Applications of Alkene Metathesis in Fine Chemical Synthesis
Bicchielli, Dario ULg; Borguet, Yannick ULg; Delaude, Lionel ULg et al

in Dragutan, Valerian; Demonceau, Albert; Dragutan, Ileana (Eds.) et al Green Metathesis Chemistry (2010)

During the last decade or so, the emergence of the metathesis reaction in organic synthesis has revolutionised the strategies used for the construction of complex molecular structures. Olefin metathesis ... [more ▼]

During the last decade or so, the emergence of the metathesis reaction in organic synthesis has revolutionised the strategies used for the construction of complex molecular structures. Olefin metathesis is indeed particularly suited for the construction of small open-chain molecules and macrocycles using crossmetathesis and ring-closing metathesis, respectively. These reactions serve, inter alia, as key steps in the synthesis of various agrochemicals and pharmaceuticals such as macrocyclic peptides, cyclic sulfonamides, novel macrolides, or insect pheromones. The present chapter is aiming at illustrating the great synthetic potential of metathesis reactions. Shortcomings, such as the control of olefin geometry and the unpredictable effect of substituents on the reacting olefins, will also be addressed. Examples to be presented include epothilones, amphidinolides, spirofungin A, and archazolid. Synthetic approaches involving silicon-tethered ring-closing metathesis, relay ring-closing metathesis, sequential reactions, domino as well as tandem metathesis reactions will also be illustrated. [less ▲]

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See detailRecent atmospheric spectroscopy applications at the Jungfraujoch and related problems
Demoulin, Philippe ULg; Mahieu, Emmanuel ULg; Mélen, Francine et al

in Proceedings of Atmospheric Spectroscopy Applications, ASA Reims 1993, September 8-10 (1993)

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See detailRecent Behavior of the North Anatolian Fault: Insights from an Integrated Paleoseismological Dataset
Fraser, J.; Vanneste, K.; Hubert, Aurelia ULg

in Journal of Geophysical Research (2010), 115(B09316),

The North Anatolian Fault (NAF) is a right‐lateral plate boundary fault that arcs across northern Turkey for ∼1500 km. Almost the entire fault progressively ruptured in the 20th century, its cascading ... [more ▼]

The North Anatolian Fault (NAF) is a right‐lateral plate boundary fault that arcs across northern Turkey for ∼1500 km. Almost the entire fault progressively ruptured in the 20th century, its cascading style indicating that stress from one fault rupture triggers fault rupture of adjacent segments. Using published paleoseismic investigations, this study integrates all of the existing information about the timing of paleoearthquakes on the NAF. Paleoseismic investigation data are compiled into a database, and for each site a Bayesian, ordering‐constrained age model is constructed in a consistent framework. Spatial variability of recurrence intervals suggests a spatial pattern in the behavior of earthquakes on the NAF that may correspond to the tectonic provinces within the Anatolian plate. In the west, the shear stress associated with the escaping Anatolian plate interplays with the tensile stress associated with the Aegean extensional province. Along this western transtensional section we recognize short recurrence intervals and switching between the furcated fault strands. The central section of the NAF is translational with little influence of fault‐normal stresses from other tectonic sources. This section tends to rupture in unison or close succession. The eastern section of the NAF is transpressional due to the compressional fault‐normal stress associated with the indenting Arabian plate. Along this section the recurrence intervals are bimodal, which we attribute to variable normal stress, although there are other possible causes. [less ▲]

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See detailRecent biogeographic and ecological studies on otter (Lutra lutra) and European mink (Mustela lutreola) in France
de Bellefroid, Marie des Neiges; Libois, Roland ULg; Rosoux, René

in Säugetierkundliche informationen (2001), 25

Otter and European mink are two threatened species in France. The mink is even considered to be on the verge of extinction. Studies have been carried out for more than ten years to attempt to understand ... [more ▼]

Otter and European mink are two threatened species in France. The mink is even considered to be on the verge of extinction. Studies have been carried out for more than ten years to attempt to understand the changes in their distribution and the ecological needs of these two semi-aquatic mustelids. The results of the research programmes completed or still under way, are presented. The French Ministry of Environment has set up two specific restoration plans, with the contribution of Conversation societies for wild fauna and scientific institutions. [less ▲]

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See detailRecent Biomonitoring Data for POP Studies in food and human
Focant, Jean-François ULg

Scientific conference (2010, March)

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See detailRecent Characteristic Budgets of Inorganic Chlorine and Fluorine above the Jungfraujoch Station
Mahieu, Emmanuel ULg; Zander, Rodolphe ULg; Mélen, Francine et al

in Harris, N. R. P.; Kilbane-Dawe, I.; Amanatidis, G.T. (Eds.) Proceedings of the 4th European Symposium on Polar Stratospheric Ozone 1997 (1998)

Within the frame of NDSC (Network for the Detection of Stratospheric Change)-related monitoring activities conducted at the International Scientific Station of the Jungfraujoch (Swiss Alps, 46.5°N, 8.0°E ... [more ▼]

Within the frame of NDSC (Network for the Detection of Stratospheric Change)-related monitoring activities conducted at the International Scientific Station of the Jungfraujoch (Swiss Alps, 46.5°N, 8.0°E, 3580 m a.s.l.), long-term investigations of the inorganic chlorine and fluorine budgets have been pursued during the last years. They are based on the analysis of high-resolution infrared solar spectra, recorded with grating and Fourier transform state-of-the-art spectrometers. Nonlinear least squares fittings of synthetic spectra to the observations are performed over selected intervals, encompassing characteristic absorptions of HCl, ClONO2, HF and COF2; this allows the retrieval of their total vertical column abundances above the Jungfraujoch and the evaluation of their budgets. [less ▲]

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See detailRecent climatic instability in Poland and effect of Little Ice Age on human activities
De Vleeschouwer, F.; Lamentovicz, M.; Piotrowska, N. et al

Poster (2008)

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See detailRecent data on a current zoonosis: alveolar echinococcus due to Echinococcus multilocularis
Hanosset, Régis; Mignon, Bernard ULg; Losson, Bertrand ULg

in Annales de Médecine Vétérinaire (2004), 148(4), 153-167

E. multilocularis is a small tapeworm which uses different species of foxes and rodents as final and intermediate hosts respectively. In humans, infection with the metacestode stage can result in a ... [more ▼]

E. multilocularis is a small tapeworm which uses different species of foxes and rodents as final and intermediate hosts respectively. In humans, infection with the metacestode stage can result in a potentially lethal liver condition named alveolar echinococcosis (AE). Recent studies in central Europe have show that E. multilocularis has a wider geographic range than previously anticipated. By the end of the 1980s, endemic areas of E. multilocularis were know to exist in only four countries, but now the parasite is present in at least 14 European countries. This paper provide recent data on the biology of E. multilocularis, the epidemiology of AE and the different tools which are available to treat or prevent this disease which seems in apparent extension. [less ▲]

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See detailRecent decline in suitable environmental conditions for African great apes
Junker, Jessica; Blake, Stephen; Boesch, Christophe et al

in Diversity & Distributions (2012), 18(11), 1077--1091

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See detailRecent demographic and behavioral data of Macaca fascicularis at Padangtegal, Bali, Indonesia
Brotcorne, Fany ULg; Wandia, I. Nengah; Rompis, A.L.T. et al

in Gumert, Michael D.; Fuentes, Agustin; Jones-Engel, Lisa (Eds.) Monkeys on the Edge. Ecology and Management of Long-tailed Macaques and their Interface with Humans. (2011)

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