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See detailMulti-disciplinary approach for sediment dynamics study of active floodplains
Gautier, E.; Corbonnois, J.; Petit, François ULg et al

in Géomorphologie : Relief, Processus, Environnement (2009)

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See detailMulti-disciplinary investigation of the tomb of Menna (TT69), Theban Necropolis, Egypt
Vandenabeele, Peter; Garcia-Moreno, Renata; Mathis, François ULg et al

in Spectrochimica Acta Part A : Molecular and Biomolecular Spectroscopy (2009), 73(3), 546-552

The archaeometrical survey of the tomb of Menna (TT69), which took place in November-December 2007, is part of the extended research program that aims to study and preserve this tomb in all its aspects ... [more ▼]

The archaeometrical survey of the tomb of Menna (TT69), which took place in November-December 2007, is part of the extended research program that aims to study and preserve this tomb in all its aspects. Menna was a high official who served as an overseer of Cadastral surveys during the reigns of pharaohs Tuthmosis IV and Amenhotep Ill (ca. 1419-1370 BC). The research team aimed to gather information, in a totally non-destructive way, on the materials used and the painting techniques. The technical examinations included photography with normal and raking light. macrophotography, ultra-violet (UV) fluorescence photography, and microscopy. On selected points X-ray fluorescence (XRF) was combined with diffuse reflectance UV-spectrometry, near infrared (NIR) diffuse reflectance spectroscopy and Raman spectroscopy. The technical aspects as well as problems that are inherently associated with an interdisciplinary survey of this extent, are discussed. The project worked with a large team of people with different backgrounds and sensitive technical equipment. Working conditions were quite hostile, including elevated temperatures and dust hampering the examinations. (C) 2008 Elsevier B.V. All rights reserved. [less ▲]

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See detailMulti-disciplinary research on long-term Middle to Upper Devonian fore-reef successions from Germany and Austria
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Cornet, Pierre et al

in Kido, Erika; Suttner, Thomas; Werer, Piller (Eds.) et al Berichte des Institutes für Erdwissenschaften, Karl-Franzens-Universität Graz (2012, June)

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See detailMulti-Domain Approaches for the Solution of High-Frequency Time-Harmonic Propagation Problems
Vion, Alexandre ULg

Doctoral thesis (2014)

The numerical solution of high-frequency time-harmonic propagation problems by volumic discretization methods is a challenging task, most notably because of the very large size of the resulting linear ... [more ▼]

The numerical solution of high-frequency time-harmonic propagation problems by volumic discretization methods is a challenging task, most notably because of the very large size of the resulting linear systems. We present a framework for a class of iterative methods that distribute the work between several CPUs and exchange information between physical or artificial interfaces. The goal is to define subproblems of manageable sizes, and to exploit the power of parallel supercomputers. [less ▲]

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See detailMulti-drug resistance in a canine lymphoid cell line due to increased P-glycoprotein expression, a potential model for drug-resistant canine lymphoma.
Zandvliet, M.; Teske, Erik ULg; Schrickx, J. A.

in Toxicology in vitro : an international journal published in association with BIBRA (2014), 28(8), 1498-506

Canine lymphoma is routinely treated with a doxorubicin-based multidrug chemotherapy protocol, and although treatment is initially successful, tumor recurrence is common and associated with therapy ... [more ▼]

Canine lymphoma is routinely treated with a doxorubicin-based multidrug chemotherapy protocol, and although treatment is initially successful, tumor recurrence is common and associated with therapy resistance. Active efflux of chemotherapeutic agents by transporter proteins of the ATP-Binding Cassette superfamily forms an effective cellular defense mechanism and a high expression of these transporters is frequently observed in chemotherapy-resistant tumors in both humans and dogs. In this study we describe the ABC-transporter expression in a canine lymphoid cell line and a sub-cell line with acquired drug resistance following prolonged exposure to doxorubicin. This sub-cell line was more resistant to doxorubicin and vincristine, but not to prednisolone, and had a highly increased P-glycoprotein (P-gp/abcb1) expression and transport capacity for the P-gp model-substrate rhodamine123. Both resistance to doxorubicin and vincristine, and rhodamine123 transport capacity were fully reversed by the P-gp inhibitor PSC833. No changes were observed in the expression and function of the ABC-transporters MRP-1 and BCRP. It is concluded that GL-40 cells represent a useful model for studying P-gp dependent drug resistance in canine lymphoid neoplasia, and that this model can be used for screening substances as potential P-gp substrates and their capacity to modulate P-gp mediated drug resistance. [less ▲]

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See detailA multi-epoch XMM-Newton campaign on the core of the massive Cygnus OB2 association
Rauw, Grégor ULg

in Astronomy and Astrophysics (2011), 536

Context. Cyg OB2 is one of the most massive associations of O-type stars in our Galaxy. Despite the large interstellar reddening towards Cyg OB2, many studies, spanning a wide range of wavelengths, have ... [more ▼]

Context. Cyg OB2 is one of the most massive associations of O-type stars in our Galaxy. Despite the large interstellar reddening towards Cyg OB2, many studies, spanning a wide range of wavelengths, have been conducted to more clearly understand this association. X-ray observations provide a powerful tool to overcome the effect of interstellar absorption and study the most energetic processes associated with the stars in Cyg OB2. <BR /> Aims: We analyse XMM-Newton data to investigate the X-ray and UV properties of massive O-type stars as well as low-mass pre-main sequence stars in Cyg OB2. <BR /> Methods: We obtained six XMM-Newton observations of the core of Cyg OB2. In our analysis, we pay particular attention to the variability of the X-ray bright OB stars, especially the luminous blue variable candidate Cyg OB2 #12. <BR /> Results: We find that X-ray variability is quite common among the stars in Cyg OB2. Whilst short-term variations are restricted mostly to low-mass pre-main sequence stars, one third of the OB stars display long-term variations. The X-ray flux of Cyg OB2 #12 varies by 37%, over timescales from days to years, whilst its mean log L[SUB]X[/SUB]/L[SUB]bol[/SUB] amounts to - 6.10. <BR /> Conclusions: These properties suggest that Cyg OB2 #12 is either an interacting-wind system or displays a magnetically confined wind. Two other X-ray bright O-type stars (MT91 516 and CPR2002 A11) display variations that suggest they are interacting wind binary systems. Based on observations collected with XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA).Full Table 2 and Table 4 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/536/A31">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/536/A31</A> [less ▲]

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See detailMulti-frequency nonlinear energy transfer from linear oscillators to mdof essentially nonlinear attachments
Tsakirtzis, Stylianos; Kerschen, Gaëtan ULg; Panagopoulos, Panagiotis et al

in Journal of Sound & Vibration (2005), 285(1-2), 483-490

We report on multi-frequency energy transfer from a two-mode, initially excited linear system to a multi-degree-of-freedom (mdof) essentially nonlinear attachment. This occurs through simultaneous ... [more ▼]

We report on multi-frequency energy transfer from a two-mode, initially excited linear system to a multi-degree-of-freedom (mdof) essentially nonlinear attachment. This occurs through simultaneous resonance interactions of both linear modes with a set of nonlinear normal modes (NNMs) of the attachment, and is studied utilizing numerical wavelet transforms. The multi-frequency nonlinear energy transfer discussed herein differs from multi-frequency energy transfer caused by resonance capture cascading where sequential energy transfer from a set of linear modes to single-dof nonlinear attachments takes place. (c) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMulti-frequency passive non-linear targeted energy transfers in systems of couples oscillators
Tsakirtzis, Stylianos; Panagopoulos, Panagiotis; Kerschen, Gaëtan ULg et al

in 5th GRACM International Congress on Computational Mechanics, Limassol, 2005 (2005, June)

We study the dynamics of a system of coupled linear oscillators with a multi-DOF end attachment with essential (nonlinearizable) stiffness nonlinearities. We show numerically that the multi-DOF attachment ... [more ▼]

We study the dynamics of a system of coupled linear oscillators with a multi-DOF end attachment with essential (nonlinearizable) stiffness nonlinearities. We show numerically that the multi-DOF attachment with damping can passively absorb broadband energy from the linear system in a one-way, irreversible fashion, acting in essence as nonlinear energy sink (NES). Strong passive targeted energy transfer from the linear to the nonlinear subsystem is possible, over wide frequency and energy ranges. We numerically demonstrate that the topological structure of the periodic orbits in the frequency – energy plane of the underlying hamiltonian system greatly influences the strength of targeted energy transfer in the damped system, and governs to a great extent the overall transient damped dynamics. This work may be regarded as a contribution towards proving the efficacy the utilizing essentially nonlinear attachments as passive broadband boundary controllers. [less ▲]

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See detailMulti-Harmonic Modelling of Motional Magnetic Field Problems using a Hybrid Finite Element--Boundary Element Discretisation
Gyselinck, J.; Geuzaine, Christophe ULg; Dular, Patrick ULg et al

in Journal of Computational & Applied Mathematics (2004), 168

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See detailMulti-Harmonic Modelling of Motional Magnetic Field Problems using a Hybrid Finite Element--Boundary Element Discretisation
Gyselinck, J.; Geuzaine, Christophe ULg; Dular, Patrick ULg et al

in 2nd international conference on advanced computational methods in engineering, ACOMEN 2002 (2002)

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See detailMulti-level dynamic state estimation for electric power systems
Rousseaux, Patricia ULg; Van Cutsem, Thierry ULg; Ribbens-Pavella, Mania

in Proceedings of the 8th Power System Computation Conference (PSCC) (1984)

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See detailMulti-level Politics in a transnational social space: the case of Brussels
Martiniello, Marco ULg

Scientific conference (1999, March 11)

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See detailThe multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5.
Hofland, Leo J.; van der Hoek, Joost; Feelders, Richard et al

in European Journal of Endocrinology (2005), 152(4), 645-654

Objective: Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity to SS ... [more ▼]

Objective: Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity to SS receptor subtypes sst1, sst2, sst3 and sst5 was recently introduced. We compared the in vitro effects of the sst2-preferring SS analogue octreotide (OCT) and the multi-ligand SOM230 on ACTH release by human and mouse corticotroph tumour cells. Methods: By quantitative RT-PCR the sst subtype expression level was determined in human corticotroph adenomas. In vitro, the inhibitory effect of OCT and SOM230 on ACTH release by dispersed human corticotroph adenoma cells and mouse AtT20 corticotroph adenoma cells was determined. In addition, the influence of dexamethasone on the responsiveness to OCT and SOM230 was studied. Results: Corticotroph adenomas expressed predominantly sst5 mRNA (six out of six adenomas), whereas sst2 mRNA expression was detected at significantly lower levels. In a 72 h incubation with 10 nmol/l SOM230, ACTH release was inhibited in three out of five cultures (range –30 to –40%). Ten nmol/l OCT slightly inhibited ACTH release in only one of five cultures (– 28%). In AtT20 cells, expressing sst2, sst3 and sst5, SOM230 inhibited ACTH secretion with high potency (IC50 0.2 nmol/l). Dexamethasone (10 nmol/l) pre-treatment did not influence the sensitivity of the cells to the inhibitory effect of SOM230, suggesting that sst5 is relatively resistant to negative control by glucocorticoids. Conclusions: The selective expression of sst5 receptors in corticotroph adenomas and the preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing’s disease. [less ▲]

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See detailA multi-method approach to radial-velocity measurement for single-object spectra
David, M.; Blomme, R.; Frémat, Y. et al

in Astronomy and Astrophysics (2014), 562

Context. The derivation of radial velocities from large numbers of spectra that typically result from survey work, requires automation. However, except for the classical cases of slowly rotating late-type ... [more ▼]

Context. The derivation of radial velocities from large numbers of spectra that typically result from survey work, requires automation. However, except for the classical cases of slowly rotating late-type spectra, existing methods of measuring Doppler shifts require fine-tuning to avoid a loss of accuracy due to the idiosyncrasies of individual spectra. The radial velocity spectrometer (RVS) on the Gaia mission, which will start operating very soon, prompted a new attempt at creating a measurement pipeline to handle a wide variety of spectral types. <BR /> Aims: The present paper describes the theoretical background on which this software is based. However, apart from the assumption that only synthetic templates are used, we do not rely on any of the characteristics of this instrument, so our results should be relevant for most telescope-detector combinations. <BR /> Methods: We propose an approach based on the simultaneous use of several alternative measurement methods, each having its own merits and drawbacks, and conveying the spectral information in a different way, leading to different values for the measurement. A comparison or a combination of the various results either leads to a "best estimate" or indicates to the user that the observed spectrum is problematic and should be analysed manually. <BR /> Results: We selected three methods and analysed the relationships and differences between them from a unified point of view; with each method an appropriate estimator for the individual random error is chosen. We also develop a procedure for tackling the problem of template mismatch in a systematic way. Furthermore, we propose several tests for studying and comparing the performance of the various methods as a function of the atmospheric parameters of the observed objects. Finally, we describe a procedure for obtaining a knowledge-based combination of the various Doppler-shift measurements. [less ▲]

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